# National Register of Historic Places listings in southern Puerto Rico

This is a list of properties and districts in the southern municipalities of Puerto Rico that are listed on the National Register of Historic Places (Spanish: Registro Nacional de Lugares Históricos). It includes places along the southern coast of the island, and on the south slope of Puerto Rico's Cordillera Central.
The area covered spans from the city of Yauco on the southwest coast to the Guayama municipality at the southeast.
Names of places given are as they appear in the National Register, reflecting name as given in NRHP application at the date of listing. Note, the National Register name system does not accommodate Spanish á, ñ and other letters.
This National Park Service list is complete through NPS recent listings posted February 14, 2025.
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* GPX (primary coordinates)
* GPX (secondary coordinates)

## Guayama

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Carretera #4 | Carretera #4 | October 30, 2020 (#100005741) | PR-15, from km. 0 in Guayama to km. 25.7 in Cayey 18°03′01″N 66°08′07″W﻿ / ﻿18.0502°N 66.1352°W﻿ / 18.0502; -66.1352﻿ (Carretera #4) | Guayama to Cayey | Former spur route of the Carretera Central which provided connection across the Sierra de Cayey. Today known as Puerto Rico Highway 15. |
| 2 | Casa Cautiño | Casa Cautiño More images | December 31, 1984 (#84003137) | 1 N. Santiago Palmer Street 17°59′09″N 66°06′48″W﻿ / ﻿17.9859°N 66.1132°W﻿ / 17.9859; -66.1132﻿ (Casa Cautiño) | Guayama Pueblo | Built in 1887, this house is one of the best remaining examples of southern Puerto Rico's 19th-century vernacular style of urban domestic architecture, blended with extensive Neoclassical elements. Especially notable is the house's masonry, wood, and metal ornamentation. It was acquired for use as a museum in 1979. |
| 3 | Cayey Bridge | Cayey Bridge More images | July 19, 1995 (#95000845) | Highway 15, km 1, spanning Río Guamaní 17°59′59″N 66°06′46″W﻿ / ﻿17.9997°N 66.1128°W﻿ / 17.9997; -66.1128﻿ (Cayey Bridge) | Caimital and Palmas | This 1891 iron bridge carries the nineteenth century highway between Guayama and Cayey, which was once the only link between the coastal east of Puerto Rico and the rest of the island. Its lateral lattice girder design is characteristic of Puerto Rico but rare in the United States. |
| 4 | Eleuterio Derkes Grammar School | Eleuterio Derkes Grammar School More images | August 4, 1987 (#87001312) | José María Anguelí Street 17°58′55″N 66°06′42″W﻿ / ﻿17.9819°N 66.1118°W﻿ / 17.9819; -66.1118﻿ (Eleuterio Derkes Grammar School) | Guayama Pueblo | Built in 1908, this school was designed during a period when schools were gaining importance as civic institutions in Puerto Rico. Its simplified Neoclassical design emphasized this shift, and it became a prototype for a generation of school construction on the island. |
| 5 | Iglesia Parroquial de San Antonio de Padua de Guayama | Iglesia Parroquial de San Antonio de Padua de Guayama More images | July 30, 1976 (#76002248) | 5 Ashford Street 17°59′07″N 66°06′46″W﻿ / ﻿17.9852°N 66.1129°W﻿ / 17.9852; -66.1129﻿ (Iglesia Parroquial de San Antonio de Padua de Guayama) | Guayama Pueblo | This church was first built in the 18th century and rebuilt twice in the 19th century and its present appearance dates from 1874. It takes an overall Romanesque form, while the details exhibit the eclecticism that characterized much Puerto Rican architecture in the later 1800s. |
| 6 | Ingenio Azucarero Vives | Ingenio Azucarero Vives More images | September 1, 1976 (#76002249) | Avenida Central 17°58′38″N 66°06′59″W﻿ / ﻿17.9771°N 66.1164°W﻿ / 17.9771; -66.1164﻿ (Ingenio Azucarero Vives) | Guayama Pueblo | The Vives Sugar Mill, built c. 1828, comprises the remains of a windmill and processing building. Constructed of river rock, cut granite, and some brick, it contrasts with later industrial buildings built primarily of brick. The mill recalls an era when the sugar industry used slave labor almost exclusively, and witnessed a slave uprising in the first half of the 19th century. |

## Guayanilla

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Padre Nazario School | Padre Nazario School More images | November 14, 2012 (#12000936) | 4 Concepción Street 18°01′08″N 66°47′25″W﻿ / ﻿18.018757°N 66.790308°W﻿ / 18.018757; -66.790308﻿ (Padre Nazario School) | Guayanilla Pueblo | Completed in 1926, this primary school epitomizes the monumental schools built in Puerto Rico during the early 20th century. Its Neoclassical and Spanish Revival details at the entry and spatial sequence of the vestibule are exceptional design features. |

## Juana Díaz

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Carretera Central | Upload image | May 2, 2019 (#100003686) | Highway 14 from Coamo boundary to Ponce boundary 18°03′04″N 66°28′45″W﻿ / ﻿18.050999°N 66.479179°W﻿ / 18.050999; -66.479179﻿ (Carretera Central) | Río Cañas Arriba, Río Cañas Abajo, Tijeras, Juana Díaz Pueblo, Jacaguas, and Callabo | Built by the Spanish administration during 1846–1886 to connect San Juan with Ponce, this was one of the first modern roadways in Puerto Rico and was regarded as one of the finest roads in the Americas for years after its completion. The listed portion of the road, from Caguas to Juana Díaz, includes the exceptionally challenging engineering through the Cordillera Central, 11 major bridges, 14 maintenance workers' houses, and numerous other roadway structures. |
| 2 | Church San Juan Bautista y San Ramón Nonato of Juana Diaz | Church San Juan Bautista y San Ramón Nonato of Juana Diaz | December 10, 1984 (#84000465) | Town Plaza 18°03′10″N 66°30′19″W﻿ / ﻿18.052897°N 66.505350°W﻿ / 18.052897; -66.505350﻿ (Church San Juan Bautista y San Ramón Nonato of Juana Diaz) | Juana Díaz Pueblo | This Baroque church built in 1807 retains most of its original design, construction, and materials, including masonry walls, towers, sacristies, interior arcades, dome, and wooden spiral stairway in the south tower. The church's placement in the town plaza and close to the town hall reflect the Crown-mandated urban design principles of the early 19th century. |
| 3 | Cueva Lucero | Cueva Lucero | September 26, 2008 (#08000936) | Address restricted | Guayabal | This cave includes more than 100 pre-Hispanic petroglyphs and pictographs dating possibly as early as the 7th century C.E., "making it one of the best examples of aboriginal rock art in the Antilles." Most of the images are zoomorphic in nature. It has been known to archaeologists since at least the early 1900s. |

## Peñuelas

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Daniel Webster School | Daniel Webster School | November 14, 2012 (#12000940) | 255 Luis Muñoz Rivera Street 18°03′16″N 66°43′20″W﻿ / ﻿18.054495°N 66.722086°W﻿ / 18.054495; -66.722086﻿ (Daniel Webster School) | Peñuelas Pueblo | Designer Francisco Gardón Vega employed a mixture of Beaux-Arts and Spanish Revival styles in this 1927 school, a common stylistic approach in Puerto Rico at the time. The school quickly became a centerpiece of public architecture in Peñuelas, surpassing the church and city hall, and remains important to local public identity. |

## Ponce

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Acueducto Alfonso XII | Acueducto Alfonso XII | December 30, 2019 (#100004854) | Calle del Acueducto 18°01′17″N 66°36′51″W﻿ / ﻿18.021358°N 66.614251°W﻿ / 18.021358; -66.614251﻿ (Acueducto Alfonso XII) | Portugués Urbano and Sexto | This aqueduct, completed in 1878 and in service until 1928, was the key component of Ponce's first system for distribution of potable water. It exemplifies 19th century design principles, and recalls civic investments to promote the welfare of urban inhabitants. Of the aqueduct's total length of 4 kilometers (2.5 mi), about 400 meters (1,300 ft) are included in the historic listing. |
| 2 | Albergue Caritativo Tricoche | Albergue Caritativo Tricoche | May 14, 1987 (#87000769) | Tricoche Street 18°01′00″N 66°36′55″W﻿ / ﻿18.016785°N 66.615193°W﻿ / 18.016785; -66.615193﻿ (Albergue Caritativo Tricoche) | Segundo | Spanish Royal Corps of Engineers-built hospital from 1878 designed in the Neoclásico Isabelino style. Part of the 19th Century Civil Architecture in Ponce NRHP thematic nomination. |
| 3 | Antiguo Cuartel Militar Español de Ponce | Antiguo Cuartel Militar Español de Ponce More images | May 14, 1987 (#87000772) | End of Castillo Street 18°00′55″N 66°36′30″W﻿ / ﻿18.015201°N 66.608439°W﻿ / 18.015201; -66.608439﻿ (Antiguo Cuartel Militar Español de Ponce) | Quinto | Spanish military headquarters in Ponce built in 1894 in the local Neoclásico Isabelino style. Its garrisoned troops participated in the 1898 Puerto Rico campaign and throughout its history it also served as a courthouse, jailhouse and today it hosts the Ponce School of Fine Arts. |
| 4 | Antiguo Hospital Militar Español de Ponce | Antiguo Hospital Militar Español de Ponce More images | May 14, 1987 (#87000770) | León, Atocha, and Bondad Streets 18°01′08″N 66°36′52″W﻿ / ﻿18.019026°N 66.614432°W﻿ / 18.019026; -66.614432﻿ (Antiguo Hospital Militar Español de Ponce) | Sexto | Spanish Royal Corps of Engineers-built military hospital from 1897 designed in the local Neoclásico Isabelino style, it was the last major Spanish building to be constructed in the Americas. Part of the 19th Century Civil Architecture in Ponce NRHP thematic nomination. |
| 5 | Armstrong-Toro House | Armstrong-Toro House More images | October 29, 1987 (#87001821) | 9 Unión Street 18°00′42″N 66°36′53″W﻿ / ﻿18.011728°N 66.614622°W﻿ / 18.011728; -66.614622﻿ (Armstrong-Toro House) | Segundo | Neoclassical designed by Manuel Domenech and built in 1899. It played an important role in the development of the Ponce Creole architectural style inspired by the Belle Époque. Today preserved as a museum by the Institute of Puerto Rican Culture. |
| 6 | Banco Crédito y Ahorro Ponceño | Banco Crédito y Ahorro Ponceño More images | June 25, 1987 (#87001002) | Junction of Marina and Amor Streets 18°00′41″N 66°36′48″W﻿ / ﻿18.011314°N 66.613333°W﻿ / 18.011314; -66.613333﻿ (Banco Crédito y Ahorro Ponceño) | Tercero | Beaux Arts-style bank building designed by Francisco Porrata Doria and built in 1924. |
| 7 | Banco de Ponce | Banco de Ponce More images | June 25, 1987 (#87001003) | Junction of Amor and Comercio Streets 18°00′40″N 66°36′48″W﻿ / ﻿18.011111°N 66.613271°W﻿ / 18.011111; -66.613271﻿ (Banco de Ponce) | Tercero | Beaux Arts-style bank building designed by Francisco Porrata Doria and also built in 1924. |
| 8 | Carretera Num. 6 | Carretera Num. 6 | September 14, 2021 (#100006919) | Road #6 $^{Coordinatesmissing}$ | Ponce vicinity | Historic 19th-century farm-to-market road constructed to link major coffee-growing areas in nearby Adjuntas with Ponce and its port for the purpose of its trade and export. |
| 9 | Casa Alcaldía de Ponce – City Hall | Casa Alcaldía de Ponce – City Hall More images | November 19, 1986 (#86003197) | South side of Plaza Las Delicias 18°00′39″N 66°36′50″W﻿ / ﻿18.010730°N 66.613905°W﻿ / 18.010730; -66.613905﻿ (Casa Alcaldía de Ponce – City Hall) | Primero | The oldest colonial building still standing in the Ponce Historic Zone, the Neoclásico Isabelino-style City Hall from 1846 is a symbol of the city charter granted by Isabella II of Spain and has served as a civic center, jailhouse and reception venue for visiting US presidents and foreign dignitaries. |
| 10 | Casa de la Masacre | Casa de la Masacre | October 20, 2005 (#05001098) | 31 Marina Street 18°00′34″N 66°36′49″W﻿ / ﻿18.009318°N 66.613537°W﻿ / 18.009318; -66.613537﻿ (Casa de la Masacre) | Cuarto | As the Ponce headquarters of the Puerto Rican Nationalist Party during the 1930s, this house bore witness to the massacre of March 21, 1937, in which 19 demonstrators and bystanders and 2 police officers were killed. It is architecturally significant as an outstanding example of vernacular creole design by Blas Silva from the first decade of the 20th century. It became a museum in 1988. |
| 11 | Casa Miguel C. Godreau | Casa Miguel C. Godreau More images | April 30, 1986 (#86000894) | 146 Reina Street 18°00′43″N 66°37′08″W﻿ / ﻿18.012054°N 66.618850°W﻿ / 18.012054; -66.618850﻿ (Casa Miguel C. Godreau) | Segundo | House from 1919, designed in an eclectic style by Julio Conesa. |
| 12 | Casa Paoli | Casa Paoli More images | October 1, 2009 (#09000769) | 14 Mayor Street 18°00′36″N 66°36′46″W﻿ / ﻿18.009928°N 66.612659°W﻿ / 18.009928; -66.612659﻿ (Casa Paoli) | Cuarto | This house was the birthplace and childhood home of great operatic tenor Antonio Paoli (1871–1946) until 1883. It was in Ponce's rich cultural environment that Paoli was first exposed to the arts, and this house is the only property remaining in Puerto Rico associated with the island's first performing artist of international renown. |
| 13 | Casa Ricardo Ruiz Mari | Upload image | May 29, 2024 (#100010382) | Calle Arias #14 17°58′52″N 66°37′20″W﻿ / ﻿17.9811°N 66.6223°W﻿ / 17.9811; -66.6223﻿ (Casa Ricardo Ruiz Mari) | Playa de Ponce | |
| 14 | Casa Vives | Casa Vives More images | February 13, 2013 (#13000013) | 88 Paseo Atocha at Vives/Castillo Street 18°00′51″N 66°36′49″W﻿ / ﻿18.014097°N 66.613524°W﻿ / 18.014097; -66.613524﻿ (Casa Vives) | Quinto | Neoclassical mansion block designed by Juan Bertoli Calderoni and built in 1860, making it one of the oldest brick and mortar residences in Ponce. It was the former residence of coffee plantation owner Carlos Vives. |
| 15 | Casino de Ponce | Casino de Ponce More images | October 28, 1987 (#87001818) | Junction of Marina and Luna Streets 18°00′36″N 66°36′48″W﻿ / ﻿18.010082°N 66.613368°W﻿ / 18.010082; -66.613368﻿ (Casino de Ponce) | Cuarto | Second Empire- and Neo-Rococo-style building from 1922, designed by Agustin Camilo Gonzalez. In addition to its role as a casino it was also used as post office, a civic office and an event venue and reception hall by local businesspeople and visiting dignitaries. |
| 16 | Castillo de Serralles | Castillo de Serralles More images | November 3, 1980 (#80004494) | Cerro El Vigía 18°01′07″N 66°37′09″W﻿ / ﻿18.018698°N 66.619274°W﻿ / 18.018698; -66.619274﻿ (Castillo de Serralles) | Portugués Urbano | Spanish Mediterranean style "castle" from 1926 designed by Pedro Adolfo de Castro and built for sugarcane magnate Juan Serrallés Colón, founder of Hacienda Mercedita. |
| 17 | Cathedral Nuestra Señora de Guadalupe of Ponce | Cathedral Nuestra Señora de Guadalupe of Ponce More images | December 10, 1984 (#84000467) | Plaza Las Delicias 18°00′43″N 66°36′50″W﻿ / ﻿18.011839°N 66.613992°W﻿ / 18.011839; -66.613992﻿ (Cathedral Nuestra Señora de Guadalupe of Ponce) | Segundo | Neoclassical cathedral from 1835 designed by Francisco Porrata Doria to replace the former church building that was previously damaged by earthquakes and fires. It is also of cultural importance as it hosts the yearly Las Mañanitas in honor of the city patroness Our Lady of Guadalupe. |
| 18 | Cementerio Antiguo de Ponce | Cementerio Antiguo de Ponce More images | January 5, 1984 (#84003149) | 1 Torre Street at Frontispicio Street 18°00′57″N 66°37′04″W﻿ / ﻿18.015833°N 66.617778°W﻿ / 18.015833; -66.617778﻿ (Cementerio Antiguo de Ponce) | Segundo | Neo-classical municipal cemetery from 1842. Its 1864 enlargement was designed by Nieto Blajol Iglesia and today it serves as a cemetery museum and as the Román Baldorioty de Castro National Pantheon. |
| 19 | Cementerio Catolico San Vicente de Paul | Cementerio Catolico San Vicente de Paul | August 25, 1988 (#88001249) | Alma Sublime Street 18°01′00″N 66°38′02″W﻿ / ﻿18.016596°N 66.633782°W﻿ / 18.016596; -66.633782﻿ (Cementerio Catolico San Vicente de Paul) | Magueyes Urbano | Historic Classical Revival, Spanish Revival, Art Deco cemetery from 1901, also known as the Catholic Cemetery of Ponce. |
| 20 | Centro Ceremonial Indígena | Centro Ceremonial Indígena More images | April 14, 1978 (#78003381) | Highway 503 18°02′32″N 66°37′18″W﻿ / ﻿18.042236°N 66.621781°W﻿ / 18.042236; -66.621781﻿ (Centro Ceremonial Indígena) | Tibes and Portugués | Archaeological site also known as the Tibes Site consisting of pre-Hispanic ceremonial ball courts or bateyes, in addition to pre-Taino burial sites dating to at least 700 AD. Part of the Ball court/plaza sites of Puerto Rico and the U.S. Virgin Islands multiple property submission. Today managed by the municipality as the Tibes Indigenous Ceremonial Center. |
| 21 | Edificio Empresas Ferré | Edificio Empresas Ferré | August 27, 2013 (#13000638) | 834 Eugenio María de Hostos Avenue 17°58′55″N 66°37′12″W﻿ / ﻿17.981903°N 66.620132°W﻿ / 17.981903; -66.620132﻿ (Edificio Empresas Ferré) | Playa | Mid 20th-century International Style office and workshop building and former headquarters of Ponce Cement and Puerto Rico Iron Works. The listing includes "La Fundición", a mural painted in its lobby by famed muralist Rafael Ríos Rey in 1953. |
| 22 | Edificio Municipal de la Playa de Ponce | Edificio Municipal de la Playa de Ponce | August 27, 2013 (#13000639) | 28 Alfonso XII Street at Padre Noel Avenue 17°58′55″N 66°37′16″W﻿ / ﻿17.981943°N 66.621142°W﻿ / 17.981943; -66.621142﻿ (Edificio Municipal de la Playa de Ponce) | Playa | Designed by Manuel V. Domenech in a Reinaissance-inspired Spanish Revival style, it served as the former municipal civic center of the Ponce Playa district, a settlement that grew in and around the Port of Ponce in the 19th century. |
| 23 | Faro de la Isla de Caja de Muertos | Faro de la Isla de Caja de Muertos More images | October 22, 1981 (#81000690) | Isla Caja de Muertos 17°53′35″N 66°31′16″W﻿ / ﻿17.893159°N 66.521189°W﻿ / 17.893159; -66.521189﻿ (Faro de la Isla de Caja de Muertos) | Playa | Spanish-built Neo-classical lighthouse from 1887 located in the island of Caja de Muertos. |
| 24 | Faro del Puerto de Ponce | Faro del Puerto de Ponce More images | October 22, 1981 (#81000691) | Isla Cardona, Ponce Harbor 17°57′24″N 66°38′06″W﻿ / ﻿17.956800°N 66.635000°W﻿ / 17.956800; -66.635000﻿ (Faro del Puerto de Ponce) | Playa | Spanish-built Neo-classical lighthouse from 1889 located in Cardona Island at the entrance to the Port of Ponce. |
| 25 | Font–Ubides House | Font–Ubides House More images | October 29, 1987 (#87001825) | 34 Castillo Street 18°00′54″N 66°36′39″W﻿ / ﻿18.014913°N 66.610786°W﻿ / 18.014913; -66.610786﻿ (Font–Ubides House) | Quinto | Historic Ponce Creole-style residence building designed by Blas C. Silva and built in 1913. |
| 26 | Hacienda Buena Vista | Hacienda Buena Vista More images | October 17, 1994 (#91001499) | Highway123, km 16.8, near Corral Viejo 18°05′03″N 66°39′17″W﻿ / ﻿18.084104°N 66.654591°W﻿ / 18.084104; -66.654591﻿ (Hacienda Buena Vista) | Magueyes | Historic and well-preserved coffee plantation from 1833. Its main plantation house was built in a traditional Spanish Colonial-style while its surrounding buildings and warehouses consist of a Vernacular style. It contains the last remaining example of a Barker hydraulic turbine in the world. |
| 27 | Iglesia de la Santísima Trinidad | Iglesia de la Santísima Trinidad More images | September 29, 1986 (#86002766) | Marina, Salud, and Abolición Streets 18°00′25″N 66°36′46″W﻿ / ﻿18.007006°N 66.612770°W﻿ / 18.007006; -66.612770﻿ (Iglesia de la Santísima Trinidad) | Cuarto | Late Gothic Revival and Mission/Spanish Revival-style church from 1926. The congregation is the first Anglican and oldest Protestant church in Puerto Rico and the only one existing prior to the American invasion in 1898. |
| 28 | La Perla Auditorium and Public Library | La Perla Auditorium and Public Library More images | September 27, 2021 (#100007054) | Calle Mayor Esq. Cristina 18°00′44″N 66°36′43″W﻿ / ﻿18.0122°N 66.6119°W﻿ / 18.0122; -66.6119﻿ (La Perla Auditorium and Public Library) | Tercero | The second oldest theater building in Puerto Rico, designed by Juan Bertoli Calderoni and built under the initiative of Francisco Parra Duperón between 1860 and 1864. |
| 29 | McCabe Memorial Church | McCabe Memorial Church | April 11, 2008 (#08000283) | 835 Eugenio María de Hostos Avenue 17°58′56″N 66°37′14″W﻿ / ﻿17.982187°N 66.620440°W﻿ / 17.982187; -66.620440﻿ (McCabe Memorial Church) | Playa | Neo-gothic church designed by Antonin Nechodoma and built in 1908 as part of a missional outreach of the American Methodist Church. It is one of the oldest Protestant congregations in Puerto Rico. |
| 30 | Mercado de las Carnes | Mercado de las Carnes | November 17, 1986 (#86003199) | Alley connecting Mayor and León Streets, between Estrella and Guadalupe Streets 18°00′56″N 66°36′46″W﻿ / ﻿18.015477°N 66.612878°W﻿ / 18.015477; -66.612878﻿ (Mercado de las Carnes) | Quinto | Early Art Deco meat market from 1926 designed by Rafael Carmoega. Built as a pedestrian mall across from the historic Ponce Marketplace it incorporates Revivalist elements inspired by Spanish Baroque and Mudéjar styles. |
| 31 | Missionary Society of the Methodist Episcopal Church | Missionary Society of the Methodist Episcopal Church | October 29, 1987 (#87001822) | 135 Villa Street 18°00′37″N 66°36′58″W﻿ / ﻿18.010405°N 66.616094°W﻿ / 18.010405; -66.616094﻿ (Missionary Society of the Methodist Episcopal Church) | Primero | Bungalow, integrating Neo-Gothic, Spanish Revival, Spanish Baroque, and byzantine elements, from 1907, designed by Antonin Nechodoma. |
| 32 | Oppenheimer House | Oppenheimer House | October 29, 1987 (#87001824) | 47 Salud Street 18°00′34″N 66°36′43″W﻿ / ﻿18.009418°N 66.611890°W﻿ / 18.009418; -66.611890﻿ (Oppenheimer House) | Cuarto | Ponce Creole-style house with elements from the Barcelona School from 1913, designed by Alfredo B. Weichers for Isabel Oppenheimer de Santiago. |
| 33 | Parque de Bombas de Ponce | Parque de Bombas de Ponce More images | July 12, 1984 (#84003150) | Plaza Las Delicias 18°00′43″N 66°36′49″W﻿ / ﻿18.011905°N 66.613738°W﻿ / 18.011905; -66.613738﻿ (Parque de Bombas de Ponce) | Segundo | Historic firehouse built in a Gothic style in 1882 by Maximo de Meana y Guridi originally as an exhibit pavilion for the 1882 Exhibition Trade Fair in Ponce. Today it serves as the Museo Parque de Bombas. |
| 34 | Ponce High School | Ponce High School | August 4, 1987 (#87001310) | Cristina Street 18°00′42″N 66°36′37″W﻿ / ﻿18.011550°N 66.610260°W﻿ / 18.011550; -66.610260﻿ (Ponce High School) | Tercero | Classical Revival school building complex from 1915, designed by Adrian C. Finlayson. At the time it was the largest school in the island and today it stands as a landmark of the history of education in Puerto Rico. |
| 35 | Ponce Public School 1913 | Upload image | August 23, 2022 (#100008052) | Calle Concordia 18°00′27″N 66°36′53″W﻿ / ﻿18.007629°N 66.614647°W﻿ / 18.007629; -66.614647﻿ (Ponce Public School 1913) | Primero | This 1913 school was designed by insular architect Albert B. McCulloch using the Mission Revival and Classical Revival styles. It is architecturally significant as a well-preserved example of the Puerto Rican school buildings of the early 20th century, a period of great transformation in Puerto Rico under the American administration. |
| 36 | Ponce YMCA Building | Ponce YMCA Building | June 4, 2012 (#12000331) | 7843 Nazaret Street, Urbanización Santa María 18°00′21″N 66°37′02″W﻿ / ﻿18.005888°N 66.617149°W﻿ / 18.005888; -66.617149﻿ (Ponce YMCA Building) | Canas Urbano | Historic YMCA famous for its mural "El Hombre" by famed artist Rafael Ríos Rey. Part of the Rafael Rios Rey Multiple Property Submission. |
| 37 | Puente Río Inabón | Puente Río Inabón | May 29, 2024 (#100010383) | Carretera Num. 1, Km. 120.4 18°00′13″N 66°33′08″W﻿ / ﻿18.0037°N 66.5522°W﻿ / 18.0037; -66.5522﻿ (Puente Río Inabón) | | |
| 38 | Puente Río Portugués | Puente Río Portugués More images | January 6, 2015 (#14001134) | Eugenio María de Hostos Avenue, spanning the historic channel of Río Portugués 17°59′36″N 66°36′55″W﻿ / ﻿17.993399°N 66.615293°W﻿ / 17.993399; -66.615293﻿ (Puente Río Portugués) | Playa | Historic Art Deco bridge from 1933 built to replace an important bridge along the Carretera Central which had been previously destroyed by flooding. |
| 39 | Rosaly–Batiz House | Rosaly–Batiz House | September 29, 1986 (#86002768) | 125 Villa Street 18°00′39″N 66°36′55″W﻿ / ﻿18.01072°N 66.61522°W﻿ / 18.01072; -66.61522﻿ (Rosaly–Batiz House) | Primero | Italian Renaissance Palazzo house designed by Manuel V. Domenech in 1897 for the mayor of Ponce Pedro Juan Rosaly. |
| 40 | Salazar–Candal House | Salazar–Candal House More images | June 9, 1988 (#88000663) | 53 Isabel Street 18°00′45″N 66°36′42″W﻿ / ﻿18.012546°N 66.611729°W﻿ / 18.012546; -66.611729﻿ (Salazar–Candal House) | Tercero | Distinctive Ponce Creole-style house from 1911, designed by Blas C. Silva for Dr. Guillermo Salazar Palau and his wife Sara Isabel Rivera Carbonell. Today it hosts the Ponce History Museum. |
| 41 | Subirá House | Subirá House | October 28, 1987 (#87001826) | 107 Reina Street 18°00′43″N 66°36′58″W﻿ / ﻿18.012038°N 66.616116°W﻿ / 18.012038; -66.616116﻿ (Subirá House) | Segundo | Historic Ponce Creole-style house from 1910, designed by Blas C. Silva for Concepción Subirá Echevarría and her husband Manuel Frau de la Sierra. |
| 42 | Fernando Luis Toro Casa | Fernando Luis Toro Casa More images | March 5, 1986 (#86000421) | 3 Obispado Street, La Alhambra 18°01′04″N 66°36′21″W﻿ / ﻿18.017812°N 66.605786°W﻿ / 18.017812; -66.605786﻿ (Fernando Luis Toro Casa) | Machuelo Abajo | Historic home with eclectic architecture inspired by the Victorian, Georgian, Neo-classic, Beaux Arts, Spanish Revival and Catalan Modernist styles, designed by Francisco Porrata Doria in 1927. |
| 43 | U.S. Custom House | U.S. Custom House More images | February 10, 1988 (#88000073) | Junction of Bonaire and Aduana Streets 17°58′47″N 66°37′12″W﻿ / ﻿17.979817°N 66.619953°W﻿ / 17.979817; -66.619953﻿ (U.S. Custom House) | Playa | Built in 1842, it is the oldest custom house in Puerto Rico, designed in a Spanish colonial-style possibly by Albert B. Nichols. It served as the Ponce headquarters for Nelson A. Miles during the Puerto Rico campaign of the Spanish–American War. |
| 44 | Villaronga House | Villaronga House | August 24, 1984 (#84003151) | 106 Reina Street 18°00′44″N 66°36′57″W﻿ / ﻿18.012310°N 66.615850°W﻿ / 18.012310; -66.615850﻿ (Villaronga House) | Segundo | Historic Classical Revival house from 1921, designed by Alfredo B. Wiechers. Today it is owned by the Institute of Puerto Rican Culture and hosts the Ponce Museum of Architecture. |
| 45 | Zaldo de Nebot Residencia | Zaldo de Nebot Residencia | June 9, 1988 (#88000643) | 27 Marina Street 18°00′35″N 66°36′49″W﻿ / ﻿18.009685°N 66.613687°W﻿ / 18.009685; -66.613687﻿ (Zaldo de Nebot Residencia) | Primero | Built to a Neoclassical design in 1895, this house is one of the fullest expressions of 19th century architecture for Ponce's wealthy creole class. Notable are the trompe-l'œil interior wall paintings of Parisian landmarks and fin de siècle decorative detailing. |

## Salinas

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Central Aguirre Historic District | Central Aguirre Historic District | October 23, 2002 (#02001208) | Highway 705, south from Highway 3, km 151.3 17°57′20″N 66°13′29″W﻿ / ﻿17.955628°N 66.224612°W﻿ / 17.955628; -66.224612﻿ (Central Aguirre Historic District) | Aguirre | Historic district consisting of the Central Aguirre sugar mill and neighboring company town from 1899. Many contributing buildings are a prime example of the Late 19th and Early 20th Century American Movements, particular the Traditional industrial style. |

## Santa Isabel

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Dr. Martin G. Brumbaugh Graded School | Dr. Martin G. Brumbaugh Graded School | February 4, 2011 (#10001217) | 33 Eugenio M. de Hostos Street 17°58′04″N 66°24′15″W﻿ / ﻿17.967723°N 66.404196°W﻿ / 17.967723; -66.404196﻿ (Dr. Martin G. Brumbaugh Graded School) | Santa Isabel Pueblo | Historic school building from 1906. |
| 2 | Iglesia Cristiana | Iglesia Cristiana | May 29, 2024 (#100010384) | 110 Luis Muñoz Rivera Street 17°57′52″N 66°24′17″W﻿ / ﻿17.964356°N 66.404857°W﻿ / 17.964356; -66.404857﻿ (Iglesia Cristiana) | Santa Isabel Pueblo | Mission/Spanish Colonial-style representing a breakaway in both religious and architectural norms of the time, being the first Protestant church to be built in a main town square (plaza) in Puerto Rico. |
| 3 | Sistema de riego de las tres haciendas | Upload image | December 13, 2016 (#16000853) | Linear district roughly parallel to Highway 153, between Highway 52 to the north and Highway 1 to the south 17°58′47″N 66°23′23″W﻿ / ﻿17.979684°N 66.389632°W﻿ / 17.979684; -66.389632﻿ (Sistema de riego de las tres haciendas) | Boca Velázquez, Jauca II, Felicia II, Felicia I, Santa Isabel Pueblo | Historic irrigation system built to transport water from the Coamo River to the Hacienda Santa Isabel, Florida and El Destino sugarcane plantations. |

## Yauco

| | Name on the Register | Image | Date listed | Location | Barrio | Description |
| 1 | Casa Agostini | Casa Agostini | June 9, 1988 (#88000682) | Dr. Gatell Street, between Santiago Vivaldi and Comercio Streets 18°02′04″N 66°50′53″W﻿ / ﻿18.034566°N 66.847933°W﻿ / 18.034566; -66.847933﻿ (Casa Agostini) | Yauco Pueblo | A Classical Revival building designed by Miguel Briganti Pinti as both a residence and coffee warehouse for Corsican immigrant Jose Maria Agostini Santini. |
| 2 | Casa Franceschi Antongiorgi | Casa Franceschi Antongiorgi | January 16, 1985 (#85000113) | Junction of 25th of July Street and Barbosa Street 18°02′01″N 66°50′55″W﻿ / ﻿18.033505°N 66.848713°W﻿ / 18.033505; -66.848713﻿ (Casa Franceschi Antongiorgi) | Yauco Pueblo | A Beaux Arts-style house from 1907. Also known as the Flemming House. |
| 3 | Casona Césari | Casona Césari | January 16, 1985 (#85000114) | 25th of July Street 18°02′00″N 66°51′05″W﻿ / ﻿18.033277°N 66.851263°W﻿ / 18.033277; -66.851263﻿ (Casona Césari) | Yauco Pueblo | Historic Puerto Rican creole vernacular house designed by Antonio Mattei Lluberas and built by built in 1893 by Angelo Cesari Poggi in 1893. |
| 4 | Chalet Amill | Chalet Amill | January 16, 1985 (#85000115) | 33 Mattei Lluveras Street 18°02′08″N 66°51′00″W﻿ / ﻿18.035620°N 66.850109°W﻿ / 18.035620; -66.850109﻿ (Chalet Amill) | Yauco Pueblo | Historic Beaux Arts house built in 1914 for Angel Antongiorgi Paoli. It formerly served as a hotel. |
| 5 | Filardi House | Filardi House More images | January 16, 1985 (#85000116) | Junction of 25th of July Street and Baldorioty Street 18°02′00″N 66°51′00″W﻿ / ﻿18.033258°N 66.849906°W﻿ / 18.033258; -66.849906﻿ (Filardi House) | Yauco Pueblo | This 1916 house is notable for its extensive use of concrete sculptural ornamentation. Juan Bautista and Domingo Filardi integrated the outstanding decorative features with the overall Beaux-Arts plan, and later came to be recognized as experts in cast concrete ornamental elements. |
| 6 | Logia Masónica Hijos de la Luz | Logia Masónica Hijos de la Luz More images | June 9, 1988 (#88000684) | José Celso Barbosa Avenue 18°01′55″N 66°50′54″W﻿ / ﻿18.031929°N 66.848455°W﻿ / 18.031929; -66.848455﻿ (Logia Masónica Hijos de la Luz) | Yauco Pueblo | Possibly the first or at least oldest masonic lodge in Puerto Rico, it was designed in the Classical Revival-style by André Troublard and built by Jesus Emmanuelli in 1894. |
| 7 | Public Health Unit at Yauco | Upload image | October 14, 2021 (#100007078) | 64 Comercio St. 18°02′05″N 66°51′13″W﻿ / ﻿18.0346°N 66.8536°W﻿ / 18.0346; -66.8536﻿ (Public Health Unit at Yauco) | Yauco Pueblo | Historic community health services unit building built in 1937 in the Spanish Revival-style. |
| 8 | Residencia González Vivaldi | Residencia González Vivaldi More images | February 5, 1987 (#86003201) | 26 Mattei Lluveras Street 18°02′09″N 66°50′53″W﻿ / ﻿18.035823°N 66.847939°W﻿ / 18.035823; -66.847939﻿ (Residencia González Vivaldi) | Yauco Pueblo | Vernacular Creole-style house from 1880 with elements of Art Nouveau. |
| 9 | Teatro Ideal | Teatro Ideal | June 9, 1988 (#88000683) | Comercio Street 18°02′05″N 66°50′54″W﻿ / ﻿18.034752°N 66.848372°W﻿ / 18.034752; -66.848372﻿ (Teatro Ideal) | Yauco Pueblo | Early 20th-century eclectic historic theater located in the main town square of Yauco. |