OpenLLM-France/wikimedia huggingface dataset:
# 1935 Southern Conference men's basketball tournament

The 1935 Southern Conference men's basketball tournament took place from February 28–March 2, 1935, at Thompson Gym in Raleigh, North Carolina. The North Carolina Tar Heels won their fifth Southern Conference title, led by head coach Bo Shepard.

## Format

The top eight finishers of the conference's ten members were eligible for the tournament. Teams were seeded based on conference winning percentage. The tournament used a preset bracket consisting of three rounds.

## Bracket

| Quarterfinals February 28 | Quarterfinals February 28 | Quarterfinals February 28 | Semifinals March 1 | Semifinals March 1 | Semifinals March 1 | Finals March 2 | Finals March 2 | Finals March 2 |
| North Carolina | North Carolina | 46 | | | | | | |
| South Carolina | South Carolina | 25 | | | | | | |
| South Carolina | South Carolina | 25 | North Carolina | North Carolina | 30 | | | |
| | | | NC State | NC State | 28 | | | |
| NC State | NC State | 42 | NC State | NC State | 28 | | | |
| VMI | VMI | 30 | | | | | | |
| VMI | VMI | 30 | | | | North Carolina | North Carolina | 35 |
| | | | | | | Washington and Lee | Washington and Lee | 27 |
| Duke | Duke | 39 | | | | | | | Washington and Lee | Washington and Lee | 27 |
| Virginia | Virginia | 32 | | | | | | |
| Virginia | Virginia | 32 | Washington and Lee | Washington and Lee | 31 | | | |
| | | | Duke | Duke | 27 | | | |
| Washington and Lee | Washington and Lee | 29 | Duke | Duke | 27 | | | |
| Clemson | Clemson | 25 | | | | | | |
* Overtime game
# 1936 SEC men's basketball tournament

The 1936 Southeastern Conference men's basketball tournament took place on February 28–March 2, 1936, in Knoxville, Tennessee at Alumni Memorial Gym. It was the third SEC basketball tournament.
Tennessee won the tournament by beating Alabama in the championship game.

## Bracket

| First Round | First Round | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Finals | Finals |
| | | Georgia Tech | 42 | | | | |
| | | Vanderbilt | 37 | | | | |
| | | | | Georgia Tech | 34 | | |
| | | | | Alabama | 43 | | |
| | | Alabama | 52 | | | | |
| | | LSU | 30 | | | | |
| | | | | | | Alabama | 25 |
| | | | | | | Tennessee | 29 |
| | | Kentucky | 41 | | | | |
| | | Mississippi State | 39 | | | | |
| | | | | Kentucky | 28 | | |
| | | | | Tennessee | 39 | | |
| | | Tennessee | 43 | | | | |
| | | Auburn | 25 | | | | |
| Auburn | 43 | Auburn | 25 | | | | |
| Georgia | 26 | | | | | | |
# 1934 Paris–Nice

The 1934 Paris–Nice was the second edition of the Paris–Nice cycle race and was held from 7 March to 11 March 1934. The race started in Paris and finished in Nice. The race was won by Gaston Rebry.

## General classification

| Rank | Rider | Time |
| 1 | Gaston Rebry (BEL) | 33h 47' 06" |
| 2 | Roger Lapébie (FRA) | + 6' 24" |
| 3 | Maurice Archambaud (FRA) | + 8' 45" |
| 4 | Jules Merviel (FRA) | + 11' 18" |
| 5 | Raymond Louviot (FRA) | + 18' 20" |
| 6 | René Vietto (FRA) | + 25' 05" |
| 7 | Edgard De Caluwé (BEL) | + 25' 37" |
| 8 | Georges Speicher (FRA) | + 30' 42" |
| 9 | Léon Level (FRA) | + 30' 45" |
| 10 | Théo Herckenrath (BEL) | + 33' 37" |
# WIBA-FM

WIBA-FM (101.5 MHz) is a radio station licensed to Sauk City, Wisconsin, United States, serving Madison and south central Wisconsin. The station is owned and operated by iHeartMedia (formerly Clear Channel Communications) and broadcasts a classic rock music format on its primary HD radio, while its HD2 channel carries an oldies format that is simulcast to analog translator station W265CV (100.9 FM).

## Station History

Originally licensed to the city of Madison, Wisconsin (the station's city of license would be moved to Sauk City in the 2010s), WIBA-FM commenced broadcasting on October 31, 1969, with an automated easy listening format during the daytime, and at night a live-hosted free-form mix of primarily rock, folk, and blues. The nickname “Radio Free Madison” or “RFM” was coined to distinguish the evening programming from the daytime content. During the 1970s, WIBA-FM transitioned to a full time freeform format, dropping the AM simulcast, and featuring local artists through such programs as Television, WIBA-FM's simulcast of the WMTV late-night weekend music program. In 1981 WIBA-FM overnight switched to its classic rock format.
WIBA-FM's current programming includes the Premiere Networks-syndicated Bob & Tom Show, heard weekdays 6AM-10AM, and Sixx Sense with Nikki Sixx in the 7PM-12AM weeknight slot. WIBA-FM also serves as Madison's FM home of Green Bay Packers football and Wisconsin Badgers football and men's basketball, in a simulcast with WIBA (AM).

### HD Radio

WIBA-FM transmits a multiplexed HD Radio signal. The station's HD2 sidechannel launched in the mid-2000s and originally aired an all-comedy format, until converting to a commercial-free alternative rock format in 2007, chiefly employing announcers and alt-rock playlists from Clear Channel's national format lab but employing the former "Mad Radio" branding that previously used on two other Clear Channel Madison stations (at 92.1 FM and 96.3 FM).
In Fall 2013, "Mad Radio" would be replaced by a simulcast of "Socially Sound Radio," an iHeartRadio Top 40/pop channel that emphasizes songs and artists that generate interest among social media platforms. After iHeartRadio dropped Socially Sound in Summer 2014, 101.5-HD2 would feature a rotation of various iHeartRadio channels, among them "Roots of Rock" (1960s/1970s progressive/album rock), "My 80s" (80s pop songs), and "re-Covered Radio" (modern cover versions of iconic songs).
In November 2016, WIBA-FM-HD2 would convert to a simulcast of all-sports sister station WTSO (1070 AM), which already had a presence on FM since 2014 at 100.9 MHz (W265CV). The move ensured W265CV's official status as a relay of WIBA-FM, as indicated in the FCC database. The WTSO simulcast would end on February 1, 2020, when W265CV and WIBA-FM-HD2 would convert to an oldies format branded as "U100.9".
WIBA-FM briefly had an HD3 subchannel in 2012, simulcasting the news/talk format of WIBA (1310 kHz).

## Translators

The following analog FM translator rebroadcasts the HD2 subchannel of WIBA-FM.
# Tren

Tren may refer to:
* Tris(2-aminoethyl)amine, a monomer or coordination chemistry compound
* Trenbolone, a veterinary steroid
* Tren, a 1978 Yugoslav film
* Trenbolone acetate, an anabolic steroid often colloquially referred to as "tren".
# Montevideo 1938 chess tournament

The eighth South American Chess Championship (Torneo Sudamericano) took place in Montevideo, Uruguay, from 7th to 25 March 1938. The event was held in an elegant seaside resort Carrasco, one of the most expensive neighborhoods in Montevideo, located on the city's southeast coast.
The results and standings:
Montevideo (Carrasco) 1938 :
| # | Player | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | Total |
| 1 | Alexander Alekhine (France) | x | ½ | 1 | 1 | ½ | 1 | ½ | 1 | 1 | ½ | 1 | 1 | 1 | 1 | 1 | 1 | 13.0 |
| 2 | Carlos Guimard (Argentina) | ½ | x | 1 | 1 | 0 | ½ | 1 | 1 | 0 | 1 | 1 | 1 | ½ | 1 | 1 | 1 | 11.5 |
| 3 | Virgilio Fenoglio (Argentina) | 0 | 0 | x | 0 | 1 | 1 | 1 | ½ | ½ | 1 | 1 | ½ | 1 | 1 | 1 | 1 | 10.5 |
| 4 | Adhemar da Silva Rocha (Brazil) | 0 | 0 | 1 | x | 1 | 1 | ½ | 1 | ½ | ½ | 1 | ½ | ½ | ½ | 1 | ½ | 9.5 |
| 5 | Carlos Maderna (Argentina) | ½ | 1 | 0 | 0 | x | 0 | 1 | 0 | ½ | 1 | ½ | 1 | 1 | ½ | 1 | 1 | 9.0 |
| 6 | Roberto Grau (Argentina) | 0 | ½ | 0 | 0 | 1 | x | ½ | 1 | ½ | 0 | 1 | 1 | ½ | 1 | 1 | 1 | 9.0 |
| 7 | Walter Cruz (Brazil) | ½ | 0 | 0 | ½ | 0 | ½ | x | ½ | ½ | 1 | ½ | ½ | 1 | ½ | 1 | 1 | 8.0 |
| 8 | Rodrigo Flores (Chile) | 0 | 0 | ½ | 0 | 1 | 0 | ½ | x | 0 | 1 | ½ | ½ | 1 | ½ | 1 | 1 | 7.5 |
| 9 | Octavio Trompowsky (Brazil) | 0 | 1 | ½ | ½ | ½ | ½ | ½ | 1 | x | ½ | 1 | ½ | 0 | ½ | 0 | 0 | 7.0 |
| 10 | Alfredo Olivera (Uruguay) | ½ | 0 | 0 | ½ | 0 | 1 | 0 | 0 | ½ | x | ½ | ½ | 1 | 1 | ½ | ½ | 6.5 |
| 11 | Julio Balparda (Uruguay) | 0 | 0 | 0 | 0 | ½ | 0 | ½ | ½ | 0 | ½ | x | 1 | ½ | 1 | 0 | 1 | 5.5 |
| 12 | Armando Salles Oliveira (Brazil) | 0 | 0 | ½ | ½ | 0 | 0 | ½ | ½ | ½ | ½ | 0 | x | ½ | ½ | 1 | 0 | 5.0 |
| 13 | José Cánepa (Uruguay) | 0 | ½ | 0 | ½ | 0 | ½ | 0 | 0 | 1 | 0 | ½ | ½ | x | ½ | 0 | 1 | 5.0 |
| 14 | René Letelier (Chile) | 0 | 0 | 0 | ½ | ½ | 0 | ½ | ½ | ½ | 0 | 0 | ½ | ½ | x | ½ | 1 | 5.0 |
| 15 | Ernesto Rotunno (Uruguay) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ½ | 1 | 0 | 1 | ½ | x | ½ | 4.5 |
| 16 | Rafael Bensadon (Argentina) | 0 | 0 | 0 | ½ | 0 | 0 | 0 | 0 | 1 | ½ | 0 | 1 | 0 | 0 | ½ | x | 3.5 |
# WINT (AM)

WINT (1330 kHz) is a commercial radio station licensed to Willoughby, Ohio, serving Lake County and eastern portions of Greater Cleveland. Owned by Spirit Broadcasting, WINT serves as a local affiliate for the Columbus Blue Jackets Radio Network; Indianapolis Motor Speedway Radio Network; Motor Racing Network; Performance Racing Network; The Sean Hannity Show and The Dave Ramsey Show. The station also airs programs hosted by nationally-syndicated personalities Doug Stephan, Armstrong & Getty and Dana Loesch. In addition to a standard broadcast AM signalanalog transmission, WINT is relayed over low-power Willoughby FM translator W268CO (101.5 FM), and is also available online.

## History

The station first broadcast on January 27, 1965, as WELW. As the station's AM transmitter site (and current studio site) resides on the Eastlake-Willoughby border, the call letters stood for Eastlake and Willoughby. WELW's first format was briefly religious; subsequently, it has had top 40, country music, oldies, and news/talk formats. WELW almost always has broadcast nationality music shows, local sports and some religious programs. Spirit Broadcasting assumed ownership in February 1990. Over the years, the station has been honored countless times for its community service, as well as receiving Associated Press awards.
On March 31, 2014, as a part of the station's 50th anniversary, WELW re-launched as Integrity Radio 1330 and changed its call sign to WINT to match the branding. The station also upgraded their signal to serve more of the Cleveland radio market. In July 2015, WINT began simulcasting on translator W268CO (101.5 FM) from a site in Kirtland.

### FM translator
## Current programming

WINT carries national talk radio programs hosted by Doug Stephan, Armstrong & Getty, Sean Hannity, Dana Loesch and Dave Ramsey. Nationality programming is aired on Sunday mornings. Additionally, the station offers a small part of its broadcast schedule for purchase by program providers.
WINT was the flagship station of the Lake County Captains minor league baseball team when they moved to Ohio in 2003. The Captains are now broadcast on a stream of WJCU, but not over the air. In 2014, WINT added NASCAR and IndyCar races to its programming. The station also broadcasts area high school football and basketball games, and occasionally Lake Erie College Football games, as well as locally produced and originated shows focusing on sports talk, tech and computer, business and legal, plus veterans and senior issues.
With the realization that many polka music fans from Ohio and the Steel Belt have retired to warmer climates, WINT also began and serves as base operation for a 24/7 streaming polka website, 247polkaheaven.com, which was the first of its kind in the world. Known as the "World's Polka Network", it features polka hosts and music from across the United States and Canada.
# NOVA1

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. Both Neanderthals and Denisovans had one version and nearly all modern humans had another suggesting positive selection. Insertion of Neanderthal gene variant of the neuro-oncological ventral antigen 1 (NOVA1) gene into human cortical organoids might promote slower development and higher surface complexity in the brain models, but this may be an artefact of a CRISPR side effect, as it could not be replicated in a subsequent study.
# Comfort Tyler

Comfort Tyler (February 22, 1764 – August 5, 1827), one of the original settlers of modern Syracuse, New York, brought his family in the spring of 1788 to what became the hamlet of Onondaga Hollow on the future Seneca Turnpike, south of the city's center today. He joined Asa Danforth and Ephraim Webster, the first whites to settle there, who had obtained permission to live there from the Onondaga. Tyler built the more ambitious house in Onondaga Hollow and contributed his engineering skills to the development of Central New York.
Tyler was a member of the New York State Assembly in 1796, representing Onondaga County, and an unsuccessful Federalist candidate for the 16th congressional district in 1802, losing to John Patterson.
# Upper Ngau Tau Kok Estate

Upper Ngau Tau Kok Estate (Chinese: 牛頭角上邨) is a public housing estate in Ngau Tau Kok, Kwun Tong, Kowloon, Hong Kong, located next to Kwun Tong Garden Estate and between MTR Ngau Tau Kok station and Kowloon Bay station. After redevelopment, the estate has 9 blocks developed into 3 phases.

## Background

The whole Ngau Tau Kok Estate was separated into Upper Ngau Tau Kok Estate and Lower Ngau Tau Kok Estate, developed in late 1960s. Upper Estate was a low cost housing estate with totally 9 blocks, while Lower Estate was a resettlement estate with totally 14 blocks.
Upper Ngau Tau Kok Estate started its Phase 1 redevelopment in 1998, in which 3 new blocks were constructed in 2003 to offer totally 2,133 units. Phases 2 & 3, which demolished Blocks 1-5 in 2003 and reconstruction started in 2005 and has 6 blocks with totally 4,584 units, were built in 2009. Most of the residents are those affected by the redevelopment of Lower Ngau Tau Kok Estate.

## Houses

| Name | Type | Completion |
| Sheung Mun House | Harmony 1 | 2003 |
| Sheung Yat House | Harmony 1 | 2003 |
| Sheung Yuet House | Single Aspect Building | 2003 |
| Sheung Hing House | Harmony Special (Non Standard) | 2009 |
| Sheung Shing House | Harmony Special (Non Standard) | 2009 |
| Sheung Fu House | Harmony Special (Non Standard) | 2009 |
| Sheung Wing House | Harmony Special (Non Standard) | 2009 |
| Sheung Hong House | Harmony Special (Non Standard) | 2009 |
| Sheung Tai House | Harmony Special (Non Standard) | 2009 |

## Education

Upper Ngau Tau Kok Estate is in Primary One Admission (POA) School Net 48. Within the school net are multiple aided schools (operated independently but funded with government money) and Kwun Tong Government Primary School.
# 1939 Southern Conference men's basketball tournament

The 1939 Southern Conference men's basketball tournament took place from March 1–4, 1939 at Thompson Gym in Raleigh, North Carolina. The Clemson Tigers won their first Southern Conference title, led by head coach Joe Davis.

## Format

The top eight finishers of the conference's fifteen members were eligible for the tournament. Teams were seeded based on conference winning percentage. The tournament used a preset bracket consisting of three rounds.

## Bracket

| First round March 1 | First round March 1 | Quarterfinals March 2 | Quarterfinals March 2 | Semifinals March 3 | Semifinals March 3 | Finals March 4 | Finals March 4 | Finals March 4 |
| Clemson | 44 | | | | | | | |
| North Carolina | 43 | | | | | | | |
| North Carolina | 43 | Wake Forest | 28 | | | | | |
| | | Clemson | 30 | | | | | |
| | | | | Clemson | 49 | | | |
| | | | | Davidson | 33 | | | |
| | | Davidson | 43 | | | | | |
| | | Washington and Lee | 32 | | | | | |
| | | | | | | | Clemson | 39 |
| | | | | | | | Maryland | 27 |
| Richmond | 31 | | | | | | | | Maryland | 27 |
| VMI | 20 | | | | | | | |
| VMI | 20 | Maryland | 47 | | | | | |
| | | Richmond | 32 | | | | | |
| | | | | Maryland | 53 | | | |
| | | | | NC State | 29 | | | |
| NC State | 40 | | | | | NC State | 29 | | | |
| Duke | 39 | | | | | | | |
| Duke | 39 | The Citadel | 38 | | | | | |
| | | NC State | 40 | | | | | |
* Overtime game
# 1939 World Table Tennis Championships

The 1939 World Table Tennis Championships were held in Cairo from March 6 to March 11, 1939.
Only 11 men's teams and 5 women's teams entered the Championships. Hungary, the United States and Austria were the major nations missing. Viktor Barna and Richard Bergmann played under the England flag for the first time.

## Medalists
### Team

| Event | Gold | Silver | Bronze |
| Swaythling Cup Men's team | Czechoslovakia Miloslav Hamr Rudolf Karlecek Václav Tereba Bohumil Váňa | Yugoslavia Žarko Dolinar Tibor Harangozo Adolf Heršković Ladislav Hexner Maks Marinko | England Ernest Bubley Ken Hyde Hyman Lurie Ken Stanley Arthur Wilmott |
| Corbillon Cup Women's team | Germany Hilde Bussmann Gertrude Pritzi | Czechoslovakia Vlasta Depetrisová Marie Kettnerová Věra Votrubcová | Romania Angelica Adelstein Sári Kolozsvári |

### Individual

| Event | Gold | Silver | Bronze |
| Men's Singles | Richard Bergmann | Alojzy Ehrlich | Bohumil Váňa |
| Men's Singles | Richard Bergmann | Alojzy Ehrlich | Žarko Dolinar |
| Women's singles | Vlasta Depetrisová | Gertrude Pritzi | Samiha Naili |
| Women's singles | Vlasta Depetrisová | Gertrude Pritzi | Marie Kettnerová |
| Men's Doubles | Viktor Barna Richard Bergmann | Miloslav Hamr Josef Tartakower | Ken Hyde Hyman Lurie |
| Men's Doubles | Viktor Barna Richard Bergmann | Miloslav Hamr Josef Tartakower | Raoul Bedoc Michel Haguenauer |
| Women's Doubles | Hilde Bussmann Gertrude Pritzi | Angelica Adelstein Sári Kolozsvári | Vlasta Depetrisová Věra Votrubcová |
| Women's Doubles | Hilde Bussmann Gertrude Pritzi | Angelica Adelstein Sári Kolozsvári | Marie Kettnerová Samiha Naili |
| Mixed Doubles | Bohumil Váňa Věra Votrubcová | Václav Tereba Marie Kettnerová | Marcel Geargoura Hilde Bussmann |
| Mixed Doubles | Bohumil Váňa Věra Votrubcová | Václav Tereba Marie Kettnerová | Mansour Helmy Gertrude Pritzi |
# WIOA

WIOA (99.9 FM), branded on-air as Máxima 99.9 FM, is a radio station broadcasting a bilingual Top 40/CHR format. Licensed to San Juan, Puerto Rico, it serves the Puerto Rico area. The station is currently owned by International Broadcasting Corporation.
WIOA is simulcast on WIOC 105.1 FM in southern Puerto Rico, including Ponce, and 106.9 FM for western Puerto Rico. On October 14, 2014, Estereotempo moved frequencies from 99.9 FM to 96.5 FM, while Fresh 99.9 FM began broadcasting on October 15, 2014, with better coverage in the metropolitan area. Fresh offers a wide variety of American CHR Music. On February 3, 2025, after ten years as Fresh, the station relaunched as Máxima 99.9 FM maintaining its Top 40/CHR format. Máxima is broadcasting on 99.9 FM Metro, 105.1 FM South & 92.1 FM West covering the entire market.

## History

WIOA signed on March 1, 1961 as WFQM. It was originally owned by the Supreme Broadcasting Company of Puerto Rico, controlled by Alfredo Ramírez de Arellano y Bártoli, and it was the FM counterpart to WKYN (630 AM), known as "La Gran Cadena FM" with a beautiful music format. In 1968, the call letters were changed to WKYN-FM, with the WQBS-FM designation adopted in 1970.
By that time the three radio stations that formed the network were WQBS-AM-FM 630 & 99.9 San Juan, WORA-AM-FM 760 and 97.5 Mayagüez, and WPRP-AM-FM 910 and 105.1 Ponce. The FM stations were intended to change their call signs on September 1, 1977, to WIOA, WIOB and WIOC, respectively, but confusion with WHOA (870 AM) in San Juan required the first two stations to change. After WHOA was sold to Pedro Román Collazo and became the current WQBS, WIOA and WIOB exchanged call letters in 1985.
In 1976, the station relaunched as Estereotempo, eventually segueing into a romantic/ballad format in the late 1980s.
Estereotempo moved to WRXD 96.5 FM in San Juan on October 14, 2014, making way for Fresh, a hot adult contemporary format; the Estereotempo format was dismantled in 2018, and WIOB is no longer co-owned. WIOC continues to rebroadcast WIOA. However, the Estereotempo name and its Spanish AC returned on 96.5 in San Juan in 2023.
Originally the antenna and transmitters were located on the roof of Ponce De León 23 story building, 1st Federal Savings. Now they are located on one of the highest peaks next to El Yunque providing much better coverage.
On June 20, 2024, International Broadcasting Corporation announced a sale of WIOA/WIOC and other stations to SMD Media Group, a new conglomerate that unite three radio networks converting into a multimedia content hub across the globe.
# BCL11A

B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene.

## Function

The BCL11A gene encodes for a regulatory C2H2 type zinc-finger protein, that can bind to the DNA. Five alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported. The protein associates with the SWI/SNF complex, that regulates gene expression via chromatin remodeling.
BCL11A is highly expressed in several hematopoietic lineages, and plays a role in the switch from γ- to β-globin expression during the fetal to adult erythropoiesis transition.
Furthermore, BCL11A is expressed in the brain, where it forms a protein complex with CASK to regulate axon outgrowth and branching. In the neocortex, BCL11A binds to the TBR1 regulatory region and inhibits the expression of TBR1.
Tetramerization of BCL11A shields it from proteasomal degradation and is critical for its γ-globin repression activity.

## Clinical significance

The corresponding Bcl11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. In addition, BCL11A has been found to play a role in the suppression of fetal hemoglobin production. Therapeutic strategies aimed at increasing fetal hemoglobin production in diseases such as beta thalassemia and sickle cell anemia by inhibiting BCL11A are currently being explored.
Furthermore, heterozygous de novo mutations in BCL11A have been identified in an intellectual disability disorder, accompanied with global developmental delay and autism spectrum disorder. These mutations disrupt BCL11A homodimerization and transcriptional regulation.
BCL11A has also been identified as an important gene of interest in type-2 diabetes. Methylation of BCl11A has been hypothesized to contribute to type-2 diabetes risk, while BCL11a loss in a human islet model was demonstrated to result in an increase in insulin secretion.

## Interactions

BCL11A has been shown to interact with a number of proteins. BCL11A was initially discovered as a COUP-TFI interacting protein. In the nucleus, BCL11A forms paraspeckles that co-localize with NONO. In neurons, BCL11A interacts with CASK to regulate target genes. Furthermore, BCL11A interacts with the neuron-specific protein TBR1, which is also implicated in intellectual disability and autism spectrum disorder.