# List of U.S. Highways in North Carolina

There are 36 U.S. Highways that exist entirely or partially in the state of North Carolina. In North Carolina, all U.S. Highways are maintained by the North Carolina Department of Transportation (NCDOT).

## U.S. Highways

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| US 1 | 174.1 | 280.2 | US 1 at the SC state line | US 1 at the VA state line | 01926-01-011926 | current | |
| US 13 | 189.1 | 304.3 | I-95/I-295 in Eastover | US 13 at the VA state line | 01952-01-011952 | current | |
| US 15 | 158.5 | 255.1 | US 15 at the SC state line | US 15 at the VA state line | 01926-01-011926 | current | |
| US 17 | 284.0 | 457.1 | US 17 at the SC state line | US 17 at the VA state line | 01926-01-011926 | current | |
| US 17-1 | 183.7 | 295.6 | US 17/NC 20 in Wilmington | US 17-1 at the VA state line | 01926-01-011926 | 01932-01-011932 | Replaced by US 117 and US 301. |
| US 19 | 145.0 | 233.4 | US 19/US 129/SR 11 at the GA state line | US 19E/US 19W in Cane River | 01926-01-011926 | current | |
| US 19E | 44.9 | 72.3 | US 19/US 19W in Cane River | US 19E at the TN state line | 01930-01-011930 | current | |
| US 19W | 21.9 | 35.2 | US 19/US 19E in Cane River | US 19W at the TN state line | 01930-01-011930 | current | |
| US 21 | 124.3 | 200.0 | I-77/US 21 at the SC state line | US 21/US 221 at the VA state line | 01926-01-011926 | current | |
| US 23 | 106.0 | 170.6 | US 23/US 441/SR 15 at the GA state line | I-26/US 23 at the TN state line | 01930-01-011930 | current | |
| US 25 | 75.4 | 121.3 | US 25 at the SC state line | US 25/US 70/SR 9 at the TN state line | 01926-01-011926 | current | |
| US 29 | 168.0 | 270.4 | US 29 at the SC state line | US 29 at the VA state line | 01926-01-011926 | current | |
| US 52 | 150.0 | 241.4 | US 52 at the SC state line | US 52 at the VA state line | 01934-01-011934 | current | |
| US 64 | 608.4 | 979.1 | US 64/US 74/SR 40 at the TN state line | US 158/NC 12 in Nags Head | 01932-01-011932 | current | Longest numbered route in North Carolina. |
| US 70 | 488.0 | 785.4 | US 25/US 70/SR 9 at the TN state line | School Drive in Atlantic | 01926-01-011926 | current | |
| US 74 | 451.8 | 727.1 | US 64/US 74/SR 40 at the TN state line | Turnaround in Wrightsville Beach | 01926-01-011926 | current | |
| US 76 | 80.4 | 129.4 | US 76 at the SC state line | Water Street in Wrightsville Beach | 01934-01-011934 | current | |
| US 117 | 114.0 | 183.5 | Port of Wilmington | US 301 near Wilson | 01932-01-011932 | current | |
| US 121 | 64.0 | 103.0 | US 70/NC 10 in Lexington | US 121 at the VA state line | 01926-01-011926 | 01934-01-011934 | Replaced by US 52. |
| US 129 | 63.6 | 102.4 | US 19/US 129/SR 11 at the GA state line | US 129/SR 115 at the TN state line | 01934-01-011934 | current | |
| US 158 | 350.2 | 563.6 | US 64/US 601 in Mocksville | US 64/NC 12 in Nags Head | 01932-01-011932 | current | |
| US 170 | 141.1 | 227.1 | US 74/NC 20/NC 27 in Charlotte | US 170 at the VA state line | 01926-01-011926 | 01932-01-011932 | Replaced by US 29. |
| US 176 | 19.3 | 31.1 | US 25 Bus./NC 225 in Hendersonville | US 176 at the SC state line | 01926-01-011926 | current | |
| US 178 | 6.4 | 10.3 | US 178 at the SC state line | US 64 near Rosman | 01932-01-011932 | current | |
| US 217 | 126.7 | 203.9 | US 217 at the SC state line | US 17-1/NC 40 in Wilson | 01926-01-011926 | 01932-01-011932 | Replaced by US 301. |
| US 220 | 123.4 | 198.6 | US 1 in Rockingham | US 220 at the VA state line | 01935-01-011935 | current | |
| US 221 | 153.0 | 246.2 | US 221 at the SC state line | US 21/US 221 at the VA state line | 01930-01-011930 | current | |
| US 258 | 152.0 | 244.6 | US 17 Bus./NC 24 Bus. in Jacksonville | US 258 at the VA state line | 01932-01-011932 | current | |
| US 264 | 215.7 | 347.1 | I-440/US 64/US 64 Bus. in Raleigh | US 64 in Manns Harbor | 01932-01-011932 | current | |
| US 276 | 62.9 | 101.2 | US 276 at the SC state line | I-40 in Cove Creek | 01932-01-011932 | current | |
| US 301 | 193.7 | 311.7 | US 301/US 501 at the SC state line | US 301 at the VA state line | 01932-01-011932 | current | |
| US 311 | 62.0 | 99.8 | US 52 in Winston-Salem | US 311 at the VA state line | 01926-01-011926 | current | Shortened to Winston-Salem in 2019. |
| US 321 | 217.2 | 349.5 | US 321 at the SC state line | US 321/SR 159 at the TN state line | 01930-01-011930 | current | |
| US 401 | 173.8 | 279.7 | US 401 at the SC state line | I-85/US 1 near Wise | 01957-01-011957 | current | |
| US 411 | 112.3 | 180.7 | US 74 in Rockingham | US 311 in Madison | 01932-01-011932 | 01935-01-011935 | Replaced by US 220. |
| US 421 | 328.0 | 527.9 | Boat launch and lot in Fort Fisher | US 421/SR 34 at the TN state line | 01930-01-011930 | current | |
| US 441 | 64.5 | 103.8 | US 23/US 441/SR 15 at the GA state line | US 441/SR 71 at the TN state line | 01951-01-011951 | current | |
| US 501 | 170.0 | 273.6 | US 301/US 501 at the SC state line | US 501 at the VA state line | 01926-01-011926 | current | |
| US 521 | 3.8 | 6.1 | US 521 at the SC state line | I-485 in Charlotte | 01932-01-011932 | current | |
| US 601 | 133.6 | 215.0 | US 601 at the SC state line | US 52 in Mount Airy | 01932-01-011932 | current | |
| US 701 | 109.9 | 176.9 | US 701 at the SC state line | US 301/NC 96 in Four Oaks | 01932-01-011932 | current | |
| Former ||||||||

## Alternate routes

Since the 1930s, North Carolina has utilized alternate routes for various needs (business, bypass, or spur). In 1960, the state began utilizing special routes, which converted many alternate routes to business loops. Currently, 15 alternate routes traverse the state; most use the "A" suffix, while a few recent route additions in the eastern half of the state are signed "alternate."
| Route | Southern or western terminus | Northern or eastern terminus | mi | km | Established | Deleted | Description |
| US 1A | Southern Pines | Southern Pines | 0 | 0.0 | 1957 | 1962 | Notes. |
| US 1A | Sanford | Sanford | 0 | 0.0 | 1957 | 1960 | Notes. |
| US 1A | Cary | Raleigh | 0 | 0.0 | 1933 | 1935 | Notes. |
| US 1A | Raleigh | Raleigh | 0 | 0.0 | 1946 | 1948 | Notes. |
| US 1A | Raleigh | Raleigh | 0 | 0.0 | 1948 | 1957 | Notes. |
| US 1A | Wake Forest | Youngsville | 9.0 | 14.5 | 1953 | — | Notes. |
| US 1A | Franklinton | Franklinton | 2.7 | 4.3 | 1953 | — | Notes. |
| US 1A | Henderson | Henderson | 0 | 0.0 | 1957 | 1960 | Notes. |
| US 13A | Windsor | Windsor | 2.2 | 3.5 | 1957 | 1960 | Notes. |
| US 15A | SC line near Laurinburg | Creedmoor | 0 | 0.0 | 1936 | 1957 | Notes. |
| US 15A | Sanford | Sanford | 6.5 | 10.5 | 1957 | 1960 | Notes. |
| US 15A | Chapel Hill | Chapel Hill | 4.3 | 6.9 | 1953 | 1960 | Notes. |
| US 17A | Williamston | Williamston | 0 | 0.0 | 1954 | 1960 | Notes. |
| US 17A | Windsor | Windsor | 0 | 0.0 | 1954 | 1960 | Notes. |
| US 17A | Elizabeth City | Elizabeth City | 0 | 0.0 | 1953 | 1960 | Notes. |
| US 19A | Ela | Lake Junaluska | 0 | 0.0 | 1947 | 1948 | The first Ela–Lake Junaluska route traversed via Cherokee and Maggie Valley. The following year, it was switch with US 19. |
| US 19A | Ela | Lake Junaluska | 0 | 0.0 | 1948 | 1987 | The second Ela–Lake Junaluska route traversed via Sylva and Waynesville. It was replaced by US 74. |
| US 19A | Waynesville | Waynesville | 0 | 0.0 | 1939 | 1948 | Alternate route through downtown Waynesville, in concurrency with US 23A. Was decommissioned with US 19 was rerouted away from Waynesville. |
| US 19A | Asheville | Asheville | 2.3 | 3.7 | 1949 | 1960 | Alternate route through downtown Asheville, in concurrency with US 23A. Replaced by US 19 Business. |
| US 23A | Waynesville | Waynesville | 0 | 0.0 | 1939 | 1968 | Alternate route through downtown Waynesville, in concurrency with US 19A, until 1948. Replaced by US 23 Business. |
| US 23A | Clyde | Canton | 11.1 | 17.9 | 1962 | 1971 | Alternate route used as a connector route for a completed section of I-40, bypassing Clyde and Canton. |
| US 23A | Asheville | Asheville | 2.3 | 3.7 | 1949 | 1960 | Alternate route through downtown Asheville, in concurrency with US 19A. Replaced by US 23 Business. |
| US 23A | California | Faust | 11.1 | 17.9 | 2006 | — | Alternate route which provides access to Wolf Laurel, which is a gated community and ski resort. |
| US 25A | Hendersonville | Hendersonville | 1.0 | 1.6 | 1944 | 1960 | Alternate route in downtown Hendersonville, via Church Street. Replaced by southbound US 25. |
| US 25A | Arden | Asheville | 8.5 | 13.7 | 1934 | — | Provides an alternate route bypassing Skyland and Biltmore Forest. |
| US 29A | Kings Mountain | Gastonia | 10.0 | 16.1 | 1937 | 1938 | Provided an alternate route through Bessemer City, in concurrency with US 74A. Replaced by NC 161 and NC 274. |
| US 29A | Kannapolis | China Grove | 0 | 0.0 | 1938 | 1940 | Provided an alternate bypass route through Kannapolis, Landis and China Grove. Replaced by US 29. |
| US 29A | Kannapolis | China Grove | 0 | 0.0 | 1940 | 1948 | Provided an alternate route through downtown Kannapolis, Landis and China Grove. Replaced by US 29. |
| US 29A | Kannapolis | China Grove | 0 | 0.0 | 1948 | 1997 | Provided an alternate route from University City area, in Charlotte, to China Grove. In 1954, its southern terminus was truncated between Concord and Kannapolis. Was decommissioned and downgraded to secondary roads. |
| US 29A | Salisbury | Salisbury | 0.5 | 0.8 | 1945 | 1954 | Alternate route in downtown Salisbury, via Bank, Lee and Liberty Streets. |
| US 29A | Lexington | Lexington | 3.8 | 6.1 | 1952 | 1960 | Alternate route through downtown Lexington. Replaced by US 29 Business. |
| US 29A | Thomasville | Thomasville | 0 | 0.0 | 1952 | 1957 | Alternate route through downtown Thomasville. Was absorbed by US 29A from High Point. |
| US 29A | High Point | High Point | 0 | 0.0 | 1934 | 1948 | Alternate route through downtown High Point. Replaced by US 29. |
| US 29A | High Point | Greensboro | 0 | 0.0 | 1948 | 1991 | Alternate route from north of Thomasville, through downtown High Point and Greensboro. Historically went further west through Thomasville until 1960. Was downgraded to secondary roads, except for English Road, which continued as NC 68. |
| US 29A | Greensboro | Greensboro | 0 | 0.0 | 1938 | 1957 | Alternate route in downtown Greensboro, in concurrency with US 70A. Was downgraded to secondary roads. |
| US 29A | Reidsville | Reidsville | 5.3 | 8.5 | 1957 | 1960 | Alternate route through downtown Reidsville. Replaced by US 29 Business. |
| US 52A | Pilot Mountain | Pilot Mountain | 0 | 0.0 | 1949 | 1960 | Alternate route through downtown Pilot Mountain. Replaced by US 52 Business. |
| US 52A | Mount Airy | Mount Airy | 0 | 0.0 | 1953 | 1960 | Alternate route through downtown Mount Airy. Replaced by US 52 Business. |
| US 64A | Brevard | Brevard | 1.1 | 1.8 | 1943 | 1960 | Alternate route through downtown Brevard. Replaced by US 64 Business. |
| US 64A | Bat Cave | Morganton | 0 | 0.0 | 1940 | 1948 | Alternate route that traveled from Bat Cave, through Ruth, to Morganton. Replaced by US 64. |
| US 64A | Statesville | Statesville | 0 | 0.0 | 1954 | 1960 | Alternate route through downtown Statesville. Replaced by US 64 Business. |
| US 64A | Franklinville | Ramseur | 0 | 0.0 | 1941 | 1957 | Alternate route that traveled through Franklinville and Ramseur. Was downgraded to secondary roads, with a section to NC 22. |
| US 64A | Siler City | Siler City | 0 | 0.0 | 1952 | 1957 | Alternate route that traveled through downtown Siler City. Was downgraded to a secondary road. |
| US 64 ALT | Spring Hope | Spring Hope | 11.0 | 17.7 | 1979 | — | Alternate route through downtown Spring Hope. |
| US 64A | Rocky Mount | Rocky Mount | 0 | 0.0 | 1934 | 1949 | Alternate route in downtown Rocky Mount, via Thomas Avenue. Replaced by US 64. |
| US 64 ALT | Rocky Mount | Tarboro | 14.2 | 22.9 | 1987 | — | Alternate route that connects between Rocky Mount and Tarboro. |
| US 64 ALT | Princeville | Williamston | 31.6 | 50.9 | 1996 | — | Alternate route that travels from Princeville, through Bethel, Parmele, and Robersonville, to Williamston. |
| US 64A | Williamston | Williamston | 0 | 0.0 | 1954 | 1960 | Alternate route in downtown Williamston. Replaced by US 64 Business. |
| US 64A | Columbia | Columbia | 0 | 0.0 | 1954 | 1960 | Alternate route in downtown Columbia. Replaced by US 64 Business. |
| US 70A | Morganton | Morganton | 3.7 | 6.0 | 1938 | 1953 | Alternate route through downtown Morganton. Was downgraded to secondary roads. |
| US 70A | Hildebran | Conover | 0 | 0.0 | 1946 | 1948 | Provided an alternate bypass route south of Hickory. Replaced by US 70. |
| US 70A | Hildebran | Conover | 0 | 0.0 | 1948 | 1957 | Provided an alternate route through downtown Hickory. Was downgraded to secondary roads. |
| US 70A | Salisbury | Salisbury | 1.8 | 2.9 | 1938 | 1957 | Alternate route in Salisbury. Replaced by US 70. |
| US 70A | Lexington | Lexington | 0 | 0.0 | 1952 | 1960 | Alternate route through downtown Lexington. Replaced by US 70 Business. |
| US 70A | High Point | Greensboro | 0 | 0.0 | 1956 | 1991 | Alternate route that traversed from downtown High Point, through Jamestown, to Greensboro; in concurrency with US 29A, except in High Point. Historically went further west through Thomasville, until 1960, and further east to Efland, until 1963. Replaced by NC 68 in High Point and downgraded to secondary roads in Greensboro. |
| US 70A | High Point | High Point | 0 | 0.0 | 1934 | 1948 | Provided an alternate bypass route in High Point. Replaced by US 70. |
| US 70A | High Point | High Point | 0 | 0.0 | 1948 | 1957 | Alternate route through downtown High Point, in concurrency with US 29A. Was decommissioned when US 70A replaced US 70 through High Point. |
| US 70A | Greensboro | Greensboro | 0 | 0.0 | 1938 | 1957 | Alternate route in downtown Greensboro, in concurrency with US 29A. Was downgraded to secondary roads. |
| US 70A | Hillsborough | Hillsborough | 0 | 0.0 | 1942 | 1948 | Provided an alternate bypass route in Hillsborough. Replaced by US 70. |
| US 70A | Hillsborough | Hillsborough | 0 | 0.0 | 1948 | 1960 | Provided an alternate route through downtown Hillsborough. Replaced by US 70 Business. |
| US 70A | Durham | Raleigh | 0 | 0.0 | 1934 | 1948 | Provided an alternate route through downtown Durham and then to Raleigh. Replaced by US 70. |
| US 70A | Durham | Durham | 0 | 0.0 | 1948 | 1960 | Provided an alternate route through downtown Durham and historically to Raleigh, through Cary, until 1956. Replaced by US 70 Business. |
| US 70A | Smithfield | Smithfield | 0 | 0.0 | 1949 | 1953 | Provided an alternate route along Second and Hancock Streets in downtown Smithfield. Was downgraded to secondary roads. |
| US 70A | Pine Level | Pine Level | 0 | 0.0 | 1954 | — | Alternate route that connects Pine Level with nearby Selma and Princeton. |
| US 70A | Goldsboro | Goldsboro | 0 | 0.0 | 1957 | 1960 | Provided an alternate route through downtown Goldsboro. Replaced by US 70 Business. |
| US 70A | Kinston | Kinston | 0 | 0.0 | 1957 | 1960 | Provided an alternate route through downtown Kinston. Replaced by US 70 Business. |
| US 74A | Asheville | Forest City | 60.0 | 96.6 | 1994 | — | Alternate route that travels through downtown Asheville, connecting the cities and communities of Bat Cave, Lake Lure, Rutherfordton, Ruth and Forest City. |
| US 74A | Rutherfordton | Rutherfordton | 2.2 | 3.5 | 1949 | 1960 | Provided an alternate route through downtown Rutherfordton. Replaced by US 74 Business. |
| US 74A | Shelby | Shelby | 6.2 | 10.0 | 1936 | 1960 | Provided an alternate route through downtown Shelby. Replaced by US 74 Business. |
| US 74A | Kings Mountain | Gastonia | 10.0 | 16.1 | 1937 | 1938 | Provided an alternate route through Bessemer City, in concurrency with US 29A. Replaced by NC 161 and NC 274. |
| US 74A | Monroe | Monroe | 0 | 0.0 | 1949 | 1952 | Provided an alternate bypass in downtown Monroe, via Jefferson Street. Was downgraded to secondary roads. |
| US 74A | Monroe | Monroe | 0 | 0.0 | 1952 | 1954 | Provided an alternate route through downtown Monroe. Was downgraded to secondary roads. |
| US 74A | Rockingham | Rockingham | 0 | 0.0 | 1953 | 1957 | Provided an alternate route through downtown Rockingham, via Washington Street and Rockingham Road. Was downgraded to secondary roads. |
| US 74 ALT | Maxton | Lumberton | 15.5 | 24.9 | 2008 | — | Alternate route that connects to nearby Pembroke. |
| US 74A | Leland | Leland | 0.14 | 0.2 | 1936 | 1975 | Provided an alternate route at the intersection that US 74 cuts a corner from; was shortest U.S. alternate route in state. Was downgraded to secondary roads. |
| US 74A | Wrightsville Beach | Wrightsville Beach | 0 | 0.0 | 1938 | 1940 | Provided an alternate spur from Causeway Drive south along Waynick Boulevard. Replaced by US 76. |
| US 117A | Burgaw | Burgaw | 2.0 | 3.2 | 1953 | 1960 | Provided an alternate route through downtown Shelby. Replaced by US 117 Business. |
| US 117 ALT | Calypso | Brogden | 12.6 | 20.3 | 1988 | — | Alternate route through downtown Calypso, Mount Olive and Brogden. |
| US 117A | Goldsboro | Goldsboro | 2.8 | 4.5 | 1952 | 1960 | Provided an alternate route through downtown Goldsboro. Replaced by US 117 Business. |
| US 117 ALT | Goldsboro | Wilson | 23.4 | 37.7 | 2006 | 2009 | Alternate route that traversed from Goldsboro, through Pikeville and Fremont, to Wilson. Replaced by US 117. |
| US 158A | Oxford | Oxford | 4.7 | 7.6 | 1954 | 1971 | Was an alternate spur route that provided a partial bypass of Oxford, connecting US 158 to US 15. Replaced by I-85. |
| US 158A | Henderson | Henderson | 8.5 | 13.7 | 1951 | 1960 | Provided an alternate route through downtown Henderson. Replaced by US 158 Business. |
| US 158A | Warrenton | Warrenton | 7.5 | 12.1 | 1951 | 1960 | Provided an alternate route through downtown Warrenton. Replaced by US 158 Business. |
| US 158A | Gatesville | Gatesville | 4.9 | 7.9 | 1948 | 1960 | Provided an alternate route through downtown Gatesville. Replaced by US 158 Business. |
| US 220 ALT | Candor | Seagrove | 27.5 | 44.3 | 1979 | — | Alternate route that traverses through Candor, Biscoe, Star and Seagrove. |
| US 221A | SC line near Cliffside | Rutherfordton | 26.2 | 42.2 | 1941 | — | Alternate route that traverses from the Chesnee, South Carolina to Rutherfordton; it connects the communities and cities of Cliffside, Henrietta, Caroleen, Alexander Mills, Forest City and Spindale. |
| US 264 ALT | Zebulon | Greenville | 64.3 | 103.5 | 1980 | — | Alternate route that traverses through Middlesex, Wilson and Greenville. |
| US 264A | Wilson | Wilson | 2.0 | 3.2 | 1950 | 1960 | Provided an alternate route through downtown Wilson. Replaced by US 264 Business. |
| US 264 ALT | Wilson | Greenville | 37.8 | 60.8 | 1988 | 2003 | Provided an alternate route from west of Wilson, bypassing south of Farmville and designated on the southern half of Greenville Boulevard, in Greenville. It was absorbed by US 264 ALT, from Zebulon. |
| US 264A | Farmville | Farmville | 8.3 | 13.4 | 1955 | 1988 | Provided an alternate route through downtown Farmville. West of Main Street was replaced by NC 121, while east was downgraded to a secondary road. |
| US 264A | Greenville | Greenville | 6.2 | 10.0 | 1957 | 1960 | Provided an alternate route through downtown Greenville. Replaced by US 264 Business. |
| US 264A | Belhaven | Belhaven | 2.9 | 4.7 | 1957 | 1960 | Provided an alternate route through downtown Belhaven. Replaced by US 264 Business. |
| US 301A | Lumberton | Lumberton | 0 | 0.0 | 1954 | 1960 | Provided an alternate route through downtown Lumberton. Replaced by US 301 Business. |
| US 301A | Fayetteville | Fayetteville | 0 | 0.0 | 1952 | 1960 | Provided an alternate route through downtown Fayetteville. Replaced by US 301 Business. |
| US 301A | Wilson | Wilson | 0 | 0.0 | 1957 | 1960 | Provided an alternate route through downtown Wilson. Replaced by US 301 Business. |
| US 301A | Rocky Mount | Rocky Mount | 0 | 0.0 | 1954 | 1960 | Provided an alternate route through downtown Rocky Mount. Replaced by US 301 Business. |
| US 301A | Halifax | Halifax | 1.1 | 1.8 | 1952 | 1960 | Provided an alternate route through downtown Halifax. Replaced by US 301 Business. |
| US 321A | Lincolnton | Lincolnton | 3.4 | 5.5 | 1956 | 1960 | Provided an alternate route through downtown Lincolnton. Was downgraded to secondary roads. |
| US 321A | Granite Falls | Lenoir | 11.8 | 19.0 | 1948 | — | Alternate route through Granite Falls, Sawmills and Hudson. |
| US 321A | Lenoir | Lenoir | 5.9 | 9.5 | 1941 | 1948 | Provided an alternate bypass route east of Lenoir. Was replaced by US 321. |
| US 401A | Laurinburg | Laurinburg | 4.4 | 7.1 | 1957 | 1960 | Provided an alternate route through downtown Laurinburg. Was replaced by US 401 Business. |
| US 421A | Clinton | Clinton | 0 | 0.0 | 1952 | 1960 | Provided an alternate route through downtown Clinton. Was replaced by US 421 Business. |
| US 421A | North Wilkesboro | North Wilkesboro | 4.3 | 6.9 | 1957 | 1969 | Provided an alternate route through downtown North Wilkesboro. Was replaced by US 421 Business. |
| US 501A | Sanford | Sanford | 6.5 | 10.5 | 1957 | 1960 | Provided an alternate route through downtown Sanford. Was replaced by US 501 Business. |
| US 501A | Chapel Hill | Chapel Hill | 4.3 | 6.9 | 1953 | 1960 | Provided an alternate route through downtown Chapel Hill. Was replaced by US 501 Business. |
| US 501A | Roxboro | Roxboro | 0 | 0.0 | 1949 | 1960 | Provided an alternate route through downtown Roxboro. Was replaced by US 501 Business. |
| US 701A | Clinton | Clinton | 0 | 0.0 | 1948 | 1957 | Provided an alternate route through downtown Clinton. It was downgraded to secondary roads. |