# List of Interstate Highways in Missouri

The Interstate Highways in Missouri are the segments of the national Dwight D. Eisenhower System of Interstate and Defense Highways that are owned and maintained by the U.S. state of Missouri.

## Primary Interstates

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| I-29 | 128.584 | 206.936 | Downtown Loop in Kansas City, Missouri | I‑29 at Iowa state line south of Hamburg, IA | 01963-01-011963 | current | |
| I-35 | 114.448 | 184.186 | I‑35 at Kansas City, Missouri | I‑35 north of Eagleville | 01972-01-011972 | current | |
| I-44 | 293.184 | 471.834 | I‑44 west of Joplin | I‑70 in St. Louis | 01956-01-011956 | current | |
| I-49 | 178.717 | 287.617 | I-49 south of Pineville | I‑470 in Kansas City | 02012-12-122012 | current | Extended into Arkansas |
| I-55 | 210.45 | 338.69 | I‑55 south of Steele | I‑55/I‑64 at St. Louis | 01956-01-011956 | current | |
| I-57 | 22.056 | 35.496 | I‑55 at Sikeston | I-57 north of Charleston | — | — | Will be extended into Arkansas |
| I-64 | 40.816 | 65.687 | I‑70 at Wentzville | I‑64 at St. Louis | 01956-01-011956 | current | |
| I-66 | 340 | 550 | Kansas state line west of Joplin | Kentucky state line south of Cairo, IL | 01991-01-011991 | 02015-01-012015 | Proposed as part of the East–West TransAmerica Corridor in 1991 |
| I-70 | 250.063 | 402.437 | I‑70 at Kansas City | I‑70 at St. Louis | 01956-01-011956 | current | |
| I-72 | 2.056 | 3.309 | US 36/US 61 in Hannibal | I-72 at Hannibal | — | — | A 157-mile (253 km) extension has been proposed to Cameron |
| Former ||||||||

## Auxiliary Interstates

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| I-144 | 15.4 | 24.8 | I‑70 in Bridgeton | Missouri/Illinois state line | — | — | Proposal for what would become I-244. |
| I-155 | 10.834 | 17.436 | I‑55/US 61 east of Hayti | I‑155 east of Caruthersville | — | — | |
| I-170 | 11.255 | 18.113 | I‑64/US 40 in Richmond Heights | I‑270 in Hazelwood | — | — | |
| I-229 | 15.022 | 24.176 | I‑29/US 71 in St. Joseph | I‑29/US 59/US 71 north of St. Joseph | 01986-01-011986 | current | |
| I-244 | 21.047 | 33.872 | I‑55 south of Green Park | I‑70 in Bridgeton | — | — | Previous designation for part of I-270 |
| I-255 | 3.979 | 6.404 | I‑55 south of Green Park | I‑255/US 50 at Illinois state line south of St. Louis | — | — | Missouri section of the eastern half of beltway around St. Louis |
| I-270 | 35.497 | 57.127 | I‑55 south of Green Park | I‑270 at Illinois state line at St. Louis | — | — | Western half of beltway around St. Louis |
| I-435 | 55.184 | 88.810 | I‑435 at Kansas City | I‑435 Kansas state line at Parkville | — | — | Missouri section of the beltway around Kansas City |
| I-470 | 17.081 | 27.489 | I‑435/US 50/US 71 in Kansas City | I‑70 in Independence | 01970-01-011970 | current | |
| I-635 | 3.766 | 6.061 | I‑635 at Kansas City | I‑29/US 71 in Kansas City | — | — | |
| I-670 | 2.323 | 3.739 | I‑670 at Kansas City | I‑70/US 40 in Kansas City | — | — | |
| I-755 | 4 | 6.4 | — | — | — | — | Cancelled proposed state highway/Interstate |
| Former ||||||||

## Business routes

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| I-29 BL | 14.063 | 22.632 | I-29 / US 169 in St. Joseph | I-29 / US 59 / US Bus. 71 in Jefferson Township | — | — | |
| I-35 BL | 3.235 | 5.206 | I-35 / Route BB in Cameron | I-35 / US 36 / MO 110 in Cameron | — | — | |
| I-44 BL | 11.529 | 18.554 | I-44 / MO 43 / MO 86 in Joplin | I-44 / MO 66 in Scotland | — | — | Serves Joplin |
| I-44 BL | 4.333 | 6.973 | I-44 / MO 37 in Sarcoxie | I-44 / Old US 166 in Sarcoxie | — | — | |
| I-44 BL | 2.736 | 4.403 | I-44 / Route H in Mount Vernon | I-44 / MO 39 in Mount Vernon | — | — | |
| I-44 BL | 9.657 | 15.541 | I-44 / MO 266 in Springfield | I-44 / Route H in Springfield | — | — | |
| I-44 BL | 3.668 | 5.903 | I-44 / Old US 66 in Lebanon | I-44 / Route MM in Lebanon | — | — | |
| I-44 BL | 6.014 | 9.679 | I-44 / Route H in Waynesville | I-44 / Route Y in St. Robert | — | — | |
| I-44 BS | 2.213 | 3.561 | I-44 / Route Y and Route Z in St. Robert | Fort Leonard Wood | — | — | |
| I-44 BL | 2.449 | 3.941 | I-44 / Old US 66 in Rolla | I-44 / US 63 / Old US 66 in Rolla | — | — | |
| I-44 BL | 9.026 | 14.526 | I-44 / MO 100 / Old US 66 (1926-1933) in Pacific | I-44 / Old US 66 (1933-1985) in Pacific | 01979-01-011979 | current | |
| I-49 BL | 9.740 | 15.675 | I-49 / Route AA in Neosho | I-49 / MO 86 in Neosho | 02012-01-012012 | current | |
| I-49 BL | 22.546 | 36.284 | I-49 / MO 175 in Tipton Ford | I-49 / MO 96 / MO 171 / MO 571 in Carthage | 02012-01-012012 | current | Serves Joplin |
| I-49 BL | 2.927 | 4.711 | I-49 / Route K in Nevada | I-49 / US Bus 71 in Nevada | 02012-01-012012 | current | Replaces US Bus. 71 |
| I-49 BL | 6.109 | 9.831 | I-49 / MO 52 in Butler | I-49 / Route F / Route D in Butler | 02012-01-012012 | current | Former segment of US 71 |
| I-55 BL | 5.751 | 9.255 | I-55 / US 61 / US 62 in New Madrid | I-55 / US 61 / US 62 in New Madrid | — | — | |
| I-55 BL | 15.705 | 25.275 | I-55 / US 61 / MO 74 in Cape Girardeau | I-55 / US 61 in Fruitland | — | — | |
| I-55 BL | 5.015 | 8.071 | I-55 / US 67 / US 61 in Crystal City | I-55 / McNutt Street in Herculaneum | — | — | |
| I-57 BL | 2.94 | 4.73 | I-57 / US 60 / MO 105 in Charleston | I-57 / US 62 / MO 77 in Charleston | — | — | |
| I-70 BL | 6.665 | 10.726 | I-70 / US 40 / MO 5 in Boonville | I-70 / MO 87 in Boonville | — | — | |
| I-70 BL | 2.878 | 4.632 | I-70 / US 40 in Columbia | I-70 / US 40 in Columbia | — | — | |
| I-70 BL | 2.831 | 4.556 | I-70 / MO 94 in St. Charles | I-70 in St. Charles | — | — | |