# List of U.S. Routes in Mississippi

In the U.S. state of Mississippi, U.S. Routes are maintained by the Mississippi Department of Transportation (MDOT).

## Mainline highways

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| US 11 | 173.1 | 278.6 | I-59 at Nicholson | US 11 at the Alabama state line near Kewanee | 01926-01-011926 | current | |
| US 45 | 273.5 | 440.2 | US 45 at the Alabama state line near State Line | US 45 at the Tennessee state line near Wenesoga | 01926-01-011926 | current | |
| US 49 | 204.2 | 328.6 | US 90 at Gulfport | US 49E/US 49W at Yazoo City | 01926-01-011926 | current | Southern segment |
| US 49 | 40.9 | 65.8 | US 49E/US 49W at Tutwiler | US 49 at the Arkansas state line (Helena Bridge) near Helena | 01926-01-011926 | current | Northern segment |
| US 49E | 85.862 | 138.181 | US 49 & US 49W at Yazoo City | US 49 & US 49W at Tutwiler | 01926-01-011926 | current | |
| US 49W | 81.894 | 131.796 | US 49 & US 49E at Yazoo City | US 49 & US 49E at Tutwiler | 01926-01-011926 | current | |
| US 51 | 267.2 | 430.0 | US 51 at the Louisiana state line near Osyka | US 51 at the Tennessee state line near Horn Lake | 01926-01-011926 | current | |
| US 61 | 299.8 | 482.5 | US 61 at the Louisiana state line near Woodville | US 61 at the Tennessee state line near Lake View | 01926-01-011926 | current | |
| US 65 | 2.9 | 4.7 | US 61 in Natchez | US 65 at the Louisiana state line near Natchez | 01926-01-011926 | 02005-01-012005 | Entirely replaced by US 425 |
| US 72 | 89.9 | 144.7 | US 72 at the Tennessee state line near Barton | US 72 at the Alabama state line near Oldham | 01926-01-011926 | current | |
| US 78 | 118.0 | 189.9 | US 78 at the Tennessee state line near Olive Branch | US 78 at the Alabama state line near Tremont | 01926-01-011926 | current | |
| US 80 | 157 | 253 | US 80 at the Louisiana state line (Vicksburg Bridge) near Vicksburg | US 80 at the Alabama state line near Kewanee | 01926-01-011926 | current | |
| US 82 | 180.0 | 289.7 | US 82 at the Arkansas state line (Greenville Bridge) near Refuge | US 82 at the Alabama state line near New Hope | 01932-01-011932 | current | |
| US 84 | 179.2 | 288.4 | US 84 at the Louisiana state line (Natchez-Vidalia Bridge) near Natchez | US 84 at the Alabama state line near Waynesboro | 01926-01-011926 | current | |
| US 90 | 79.7 | 128.3 | US 90 at the Louisiana state line (East Pearl River) near Pearlington | US 90 at the Alabama state line near Pecan | 01926-01-011926 | current | |
| US 98 | 166.3 | 267.6 | US 61 at Washington | US 98 at the Alabama state line near Lucedale | 01933-01-011933 | current | |
| US 278 | 135.5 | 218.1 | US 278 at the Arkansas state line (Greenville Bridge) near Refuge | US 278 at the Alabama state line near Gattman | 01978-01-011978 | current | |
| US 425 | 2.9 | 4.7 | US 61 at Natchez, Mississippi | US 425 at the Louisiana state line (Natchez-Vidalia Bridge) near Natchez | 02005-01-012005 | current | |

## Special routes

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| US 45 Alt. | 62.9 | 101.2 | US 45 in Brooksville | US 45/US 278 in Shannon | 01968-01-011968 | current | Signed as both US 45A and US 45 Alternate |
| US 51 Bus. | — | — | US 51 south of Crystal Springs | US 51 north of Crystal Springs | — | — | |
| US 51 Bus. | — | — | US 51 south of McComb | US 51 north of McComb | — | — | Unsigned |
| US 61 Bus. | — | — | US 61 south of Leland | US 61 north of Leland | — | — | |
| US 61 Bus. | — | — | US 61 south of Natchez | US 61 north of Natchez | — | — | |
| US 61 Bus. | — | — | US 61 south of Port Gibson | US 61 north of Port Gibson | — | — | |
| US 61 Bus. | — | — | US 61 south of Vicksburg | US 61 north of Vicksburg | — | — | Conncurrent with MS 834 |