# List of U.S. Highways in South Carolina

There are 23 U.S. Highways that exist entirely or partially in the U.S. state of South Carolina. In South Carolina, all U.S. Highways are maintained by the South Carolina Department of Transportation (SCDOT).

## Mainline highways

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| US 1 | 170.540 | 274.458 | US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 / SC 121 at the Georgia state line south of North Augusta | US 1 at the North Carolina state line near Wallace | 01926-01-011926 | current | Travels north-south along the sandhills region; connecting the cities of North Augusta, Aiken, Columbia, and Camden. South of Camden, it parallels with I-20. |
| US 15 | 158.832 | 255.615 | US 17 Alt. in Walterboro | US 15 / US 401 in North Carolina state line at McColl | 01935-01-011935 | current | Travels north-south, connecting the cities of Walterboro, Sumter, and Bennettsville. |
| US 17 | 221.454 | 356.396 | US 17 / SR 404 Spur at the Georgia state line near Limehouse | US 17 at the North Carolina state line near Little River | 01927-01-011927 | current | Travels north-south along the coastal plain area, connecting the cities of Hardeeville, Charleston, Georgetown, and Myrtle Beach. |
| US 21 | 245.480 | 395.062 | Hunting Island State Park | I-77 / US 21 at the North Carolina state line near Fort Mill | 01926-01-011926 | current | Travels north-south, connecting the cities of Beaufort, Orangeburg, Columbia, and Rock Hill. North of Columbia, it parallels with I-77. |
| US 25 | 140.600 | 226.274 | US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 / SC 121 at the Georgia state line south of North Augusta | US 25 at the North Carolina state line near Travelers Rest | 01926-01-011926 | current | Travels north-south in the western part of the state, connecting the cities of North Augusta, Greenwood, and Greenville. |
| US 29 | 110.202 | 177.353 | US 29 / SR 8 at the Georgia state line near Holland Store | US 29 at the North Carolina state line northeast of Blacksburg | 01927-01-011927 | current | Travels north-south in the Upstate area, parallel to I-85. It connects the cities of Anderson, Greenville, and Spartanburg. |
| US 52 | 159.960 | 257.431 | Line Street in Charleston | US 52 at the North Carolina state line near Cheraw | 01980-02-181980 | current | Travels north-south, connecting the cities of Charleston, Lake City, Florence, and Darlington. |
| US 76 | 314.985 | 506.919 | US 76 / SR 2 at the Georgia state line near Westminster | US 76 at the North Carolina state line near Nichols | 01926-01-011926 | current | Longest US Highway in the state, going east-west; it connects the cities Anderson, Columbia, Sumter, and Florence. |
| US 78 | 142.207 | 228.860 | US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 / SC 121 at the Georgia state line near North Augusta | Line Street in Charleston | 01926-01-011926 | current | Travels east-west, connecting the cities of North Augusta, Aiken, Bamberg, and Charleston. |
| US 117 | 45.0 | 72.4 | Conway | US 117 at the North Carolina state line near Little River | 01932-01-011932 | 01935-01-011935 | Replaced by US 501 and US 17. |
| US 123 | 65.240 | 104.994 | US 123 / SR 365 at the Georgia state line near Westminster | I-385 Bus. in Greenville | 01968-01-011968 | current | Travels north-south in the Upstate area, connecting the cities of Westminster and Greenville. |
| US 176 | 230.760 | 371.372 | US 176 at the North Carolina state line near Landrum | US 52 / Red Bank Road in Goose Creek | 01926-01-011926 | current | Travels east-west, parallel to I-26. It connects the cities of Spartanburg, Union, and Columbia. |
| US 178 | 233.390 | 375.605 | US 178 at the North Carolina state line near Rocky Bottom | U.S. Route 78 in South Carolina east of Dorchester | 01932-01-011932 | current | Travels east-west, connecting the cities of Anderson, Greenwood, and Orangeburg. |
| US 217 | 24.4 | 39.3 | Pee Dee | US 217 at the North Carolina state line near Dillon | 01927-01-011927 | 01932-01-011932 | Replaced by US 301. |
| US 221 | 126.390 | 203.405 | US 221 / SC 150 at the Georgia state line near Clarks Hill | US 221 at the North Carolina state line near Chesnee | 01932-01-011932 | current | Travels north-south within the Piedmont area, connecting the cities of Greenwood and Spartanburg. |
| US 276 | 44.469 | 71.566 | US 276 at the North Carolina state line near Cleveland | I-185 / I-385 in Mauldin | 01932-01-011932 | current | Shortest US Highway in the state, going east-west; it goes through the city of Greenville. |
| US 278 | 146.130 | 235.173 | US 1 / US 25 / US 78 / US 278 / SR 10 / SR 121 / SC 121 at the Georgia state line south of North Augusta | US 278 Bus. / Greenwood Drive / Pope Avenue in Hilton Head Island | 01965-01-011965 | current | Travels east-west, connecting the cities of North Augusta and Hilton Head Island. |
| US 301 | 189.704 | 305.299 | US 301 / SR 73 at the Georgia state line near Allendale | I-95 / US 301 / US 501 at the North Carolina state line near Dillon | 01932-01-011932 | current | Travels north-south, loosely parallel to I-95. It connects the cities of Orangeburg, Florence, and Dillon. |
| US 321 | 217.550 | 350.113 | US 17 in Hardeeville | US 321 at the North Carolina state line near Clover | 01930-01-011930 | current | Travels north-south, connecting the cities of Hardeeville, Columbia, and York. |
| US 378 | 210.310 | 338.461 | US 378 / SR 43 at the Georgia state line near McCormick | US 501 Bus. in Conway | 01952-01-011952 | current | Travels east-west, connecting the cities of Columbia, Sumter, and Conway. |
| US 401 | 77.760 | 125.143 | US 76 Bus. in Sumter | US 401 at the North Carolina state line near McColl | 01957-01-011957 | current | Travels north-south, connecting the cities of Sumter, Darlington, and Bennettsville. |
| US 501 | 73.770 | 118.721 | US 17 Bus. in Myrtle Beach | I-95 / US 301 / US 501 at the North Carolina state line near Dillon | 01935-01-011935 | current | Travels north-south through the Grand Strand area, connecting the cities of Myrtle Beach, Conway, and Dillon. |
| US 521 | 172.820 | 278.127 | US 17 in Georgetown | US 521 at the North Carolina state line at Indian Land | 01932-01-011932 | current | Travels north-south, connecting the cities of Georgetown, Sumter, Camden, and Lexington. |
| US 601 | 183.370 | 295.105 | US 321 in Tarboro | US 601 at the North Carolina state line at Pageland | 01927-01-011927 | current | Travels north-south,connecting the cities of Bamberg, Orangeburg, Camden, and Pageland. |
| US 701 | 61.670 | 99.248 | US 17 / US 17 Alt. in Georgetown | US 701 at the North Carolina state line near Loris | 01932-01-011932 | current | Travels north-south through the Grand Strand area, connecting the cities of Georgetown and Conway. |
| Former ||||||||

## Special routes

| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| US 1 Truck | 8.440 | 13.583 | US 1 / US 78 / US 78 Truck / SC 19 Truck / SC 118 in Aiken | US 78 / US 78 Truck / SC 4 Truck / SC 302 east of Aiken | — | — | |
| US 1 Conn. | 0.230 | 0.370 | US 1 / SC 6 in Lexington | SC 6 in Lexington | — | — | Unsigned; southbound only; completely concurrent with the eastbound lanes of SC 6 |
| US 1 Conn. | 0.080 | 0.129 | SC 16 in Columbia | US 1 in Columbia | — | — | Unsigned |
| US 1 Truck | 1.540 | 2.478 | US 521 / US 521 Truck / SC 34 Truck in Camden | US 1 / US 521 Truck / SC 34 / SC 34 Truck in Camden | — | — | |
| US 1 Truck | 3.230 | 5.198 | US 1 / US 52 / US 52 Truck south of Cheraw | US 1 / US 52 / US 52 Truck / SC 9 / SC 9 Truck in Cheraw | — | — | Completely concurrent with US 52 Truck |
| US 15 Alt. | — | — | Walterboro | North Carolina state line near McColl | 01937-01-011937 | 01946-01-011946 | The entire route was in concurrency with US 15 in South Carolina. |
| US 15 Conn. | 2.140 | 3.444 | US 15 / US 301 southwest of Santee | SC 6 in Santee | — | — | Unsigned |
| US 15 Conn. | 2.140 | 3.444 | US 301 in Summerton | US 15 in Summerton | — | — | Unsigned |
| US 15 Alt. | — | — | Sumter | Society Hill | 01955-01-011955 | 01957-01-011957 | Replaced by US 401. |
| US 15 Conn. | 0.340 | 0.547 | US 15 on the Sumter–South Sumter line | US 521 on the Sumter–South Sumter line | — | — | Unsigned |
| US 15 Bus. | 6.500 | 10.461 | US 15 south of Hartsville | US 15 south of Hartsville | — | — | |
| US 15 Bus. | — | — | US 15 west of Bennettsville | US 15 east of Bennettsville | 01952-01-011952 | 01990-01-011990 | Was routed along Main Street and Tyson Avenue, in concurrency with US 401 Bus. It was replaced by SC 385. |
| US 17 Alt. | 6.7 | 10.8 | US 17 Alt. / SR 25 Alt. at the Georgia state line near Limehouse | US 17 near Limehouse | 01955-01-011955 | 01994-01-011994 | Provided an alternate route from Savannah, via the Talmadge Memorial Bridge. Was reassigned as mainline US 17 |
| US 17 Alt. | 123.900 | 199.398 | US 17 / US 21 northeast of Pocotaligo | US 17 / US 701 in Georgetown | 01952-01-011952 | current | Travels north–south,connecting the cities of Walterboro, Summerville, Moncks Corner, and Georgetown. |
| US 17 Conn. | 0.270 | 0.435 | Yemassee Highway in Yemassee | US 17 Alt. / US 21 / SC 68 in Yemassee | — | — | Unsigned |
| US 17 Alt. Truck | 8.242 | 13.264 | US 17 Alt. / SC 642 southwest of Summerville | US 17 Alt. / SC 165 / Berkely Circle in Summerville | — | — | |
| US 17 Bus. | 4.2 | 6.8 | US 17 / US 701 / US 701 Bus. northwest of Mount Pleasant | US 17 / US 701 / US 701 Bus. northeast of Mount Pleasant | 01967-01-011967 | 01992-01-011992 | Was routed along Coleman Boulevard and Georgetown Highway (Chuck Dawley Boulevard); completely concurrent with US 701 Bus. It was replaced by SC 703 and BS 526. |
| US 17 Bus. | 22.940 | 36.918 | US 17 in Murrells Inlet | US 17 in Myrtle Beach | 01967-01-011967 | current | Connects the downtown areas of Murrells Inlet, Garden City, Surfside Beach and Myrtle Beach. |
| US 21 Bus. | 5.400 | 8.690 | US 21 / SC 802 in Beaufort | US 21 in Burton | 01967-01-011967 | current | Routed along Sea Island Parkway, Carteret Street and Boundary Street |
| US 21 Bus. | 3.3 | 5.3 | Orangeburg | Orangeburg | 01950-01-011950 | 01967-01-011967 | Was routed along Broughton Street (in concurrency with US 178 Bus.) and Columbia Road |
| US 21 Bus. | 2.730 | 4.394 | US 21 / US 601 Truck / SC 4 in Orangeburg | US 21 / US 178 / US 601 in Orangeburg | 01967-01-011967 | current | Routed along Rowesville Road, Charleston Highway, and Magnolia Street |
| US 21 Conn. | 2.730 | 4.394 | US 178 Bus. in Orangeburg | US 21 / US 178 in Orangeburg | — | — | Unsigned |
| US 21 Conn. | 0.850 | 1.368 | US 21 / US 176 / US 321 in West Columbia | US 1 in West Columbia | — | — | Unsigned |
| US 21 Conn. | 2.930 | 4.715 | US 21 / US 76 Conn. / US 176 / US 321 / SC 48 Truck in Columbia | US 76 / US 76 Conn. / US 378 in Columbia | — | — | Unsigned; completely concurrent with the western segment of US 76 Conn. |
| US 21 Conn. | 1.660 | 2.672 | US 21 southeast of Ridgeway | SC 34 northwest of Ridgeway | — | — | Unsigned |
| US 21 Bus. | 6.7 | 10.8 | Rock Hill | Rock Hill | 01950-01-011950 | 02013-01-012013 | Was routed along Main Street, Albright Road, Black Street, Oakland Avenue, and Cherry Road, through downtown Rock Hill. It was decommissioned at the request of Rock Hill to gain ownership and maintenance oversight. |
| US 21 Bus. | 7.060 | 11.362 | SC 160 in Fort Mill | US 21 north of Fort Mill | 01948-01-011948 | current | It is routed along Spratt Street, White Street, Old Nations Road, and Springfield Parkway, through downtown Fort Mill |
| US 25 Bus. | 2.900 | 4.667 | US 25 Alt. / SR 4 at the Georgia state line in North Augusta | US 25 in North Augusta | 01961-01-011961 | current | Only business loop that crosses the Georgia state line |
| US 25 Conn. | 0.550 | 0.885 | Dead end in North Augusta | US 25 / SC 121 in North Augusta | — | — | Unsigned |
| US 25 Bus. | 3.700 | 5.955 | US 25 / US 25 Truck in Edgefield | US 25 / US 25 Truck / SC 23 Truck north of Edgefield | — | — | Is, in fact, US 25 signed as a business route |
| US 25 Truck | 3.980 | 6.405 | US 25 in Edgefield | US 25 / SC 23 Truck north of Edgefield | — | — | Is, in fact, a secondary road signed as a truck route |
| US 25 Bus. | 4.840 | 7.789 | US 25 / US 178 / US 221 in Greenwood | US 25 / US 178 / SC 72 in Greenwood | 01969-01-011969 | current | |
| US 25 Bus. | 4.310 | 6.936 | US 25 / SC 252 Truck southeast of Ware Shoals | US 25 / SC 252 / SC 252 Truck north of Ware Shoals | 01963-01-011963 | current | |
| US 25 Bus. | — | — | Greenville | Greenville | 01969-01-011969 | 01995-01-011995 | Former business loop through downtown Greenville; replaced in parts by US 123, US 276, SC 20 and SC 291. |
| US 25 Conn. | 1.100 | 1.770 | US 276 / McElhaney Road in Travelers Rest | US 25 in Travelers Rest | — | — | Unsigned |
| US 29 Bus. | 6.438 | 10.361 | US 29 on the Homeland Park–Green Acres line | US 29 in Anderson | — | — | |
| US 29 Conn. | 3.520 | 5.665 | US 29 near Williamston | SC 20 in Williamston | — | — | |
| US 29 Alt. | — | — | US 29 in Greenville | US 29 in Greenville | 01938-01-011938 | 01948-01-011948 | Was an alternate route through downtown Greenville; was downgraded to secondary roads. |
| US 29 Bus. | — | — | US 29 in Greenville | US 29 in Greenville | 01958-01-011958 | 01962-01-011962 | |
| US 29 Spur | 0.110 | 0.177 | US 29 in Greenvillw | US 276 in Greenville | — | — | Unsigned |
| US 29 Conn. | 0.250 | 0.402 | US 276 in Greenvillw | US 29 in Greenville | — | — | Unsigned |
| US 29 Conn. | 0.120 | 0.193 | SC 291 / Edwards Road on the Greenville–Wade Hampton line | US 29 in Wade Hampton | — | — | Unsigned |
| US 29 Conn. | 0.34 | 0.55 | US 29 in Spartanburg | SC 296 in Spartanburg | 02013-01-012013 | 02016-01-012016 | |
| US 29 Alt. | — | — | US 29 in Spartanburg | US 29 in Blacksburg | 01954-01-011954 | 01962-01-011962 | Was a redesignation of mainline US 29 between Spartanburg and Blacksburg; after I-85 was established, it was reverted to US 29. |
| US 52 Spur | 2.980 | 4.796 | East Bay Street / Broad Street in Charleston | US 52 / Mount Pleasant Street in Charleston | — | — | Unsigned |
| US 52 Conn. | 0.900 | 1.448 | I-26 in North Charleston | US 52 / US 78 in North Charleston | — | — | Unsigned |
| US 52 Truck | 4.780 | 7.693 | US 52 / US 301 / West 3rd Loop Road in Florence | US 52 in Florence | — | — | |
| US 52 Conn. | 1.070 | 1.722 | US 52 / US 76 in Florence | US 52 in Florence | — | — | Unsigned |
| US 52 Bus. | 4.508 | 7.255 | US 52 / SC 34 Truck in Darlington | US 52 / US 401 near Darlington | 01974-01-011974 | current | |
| US 52 Truck | 3.550 | 5.713 | US 1 / US 1 Truck / US 52 / Manor Road south of Cheraw | US 52 / SC 9 Truck in Cheraw | 02002-01-012002 | current | |
| US 76 Bus. | — | — | Seneca | Seneca | 01958-01-011958 | 02000-01-012000 | |
| US 76 Bus. | 3.910 | 6.293 | US 76 / Ashley Lane in Laurens | US 76 / US 221 Truck / SC 127 in Laurens | 01982-01-011982 | current | |
| US 76 Bus. | — | — | Newberry | Newberry | 01952-01-011952 | 02001-01-012001 | |
| US 76 Conn. | 4.440 | 7.145 | US 21 / US 21 Conn. / US 176 / US 321 / SC 48 Truck in ColumbiaSC 16 in ColumbiaSC 16 in Columbia | US 21 Conn. / US 76 / US 378 in ColumbiaUS 76 / US 378 / SC 760 in ColumbiaSC 760 in Columbia | — | — | Unsigned |
| US 76 Bus. | 5.910 | 9.511 | US 76 / US 378 in Sumter | US 76 / US 378 in Sumter | 01959-01-011959 | current | |
| US 76 Conn. | 0.140 | 0.225 | I-20 Bus. / West Evans Street in Florence | US 76 in Florence | — | — | Unsigned |
| US 78 Truck | 8.440 | 13.583 | US 1 / US 1 Truck / US 78 / SC 19 Truck / SC 118 in Aiken | US 1 Truck / US 78 / SC 4 Truck / SC 302 east of Aiken | — | — | Completely cocurrent with US 1 Truck |
| US 78 Bus. | 0.530 | 0.853 | SC 3 in Blackville | US 78 in Blackville | 01981-01-011981 | current | Inventoried by SCDOT as US 78 Conn.; signed west of SC 3, but is inventoried by SCDOT as only using these termini |
| US 78 Conn. | 0.530 | 0.853 | SC 3 in Blackville | US 78 in Blackville | — | — | Is, in fact, the official designation of the signed US 78 Bus. |
| US 78 Conn. | 0.140 | 0.225 | SC 61 northwest of Farrell Crossroads | US 78 near Farrell Crossroads | — | — | Unsigned |
| US 123 Bus. | — | — | Seneca | Seneca | 01958-01-011958 | 02000-01-012000 | Was routed along North First Street. |
| US 123 Bus. | — | — | Easley | Easley | 01958-01-011958 | 01964-01-011964 | Was routed along Main Street and Liberty Drive; replaced by SC 93 |
| US 123 Conn. | 0.740 | 1.191 | SC 93 in Easley | US 123 in Easley | — | — | |
| US 123 Alt. | — | — | Greenville | Greenville | 01950-01-011950 | 01972-01-011972 | Replaced by SC 124. |
| US 176 Alt. | — | — | US 176 in Spartanburg | US 176 in Spartanburg | 01938-01-011938 | 01948-01-011948 | Traversed downtown Spartanburg, along Magnolia and Howard streets; some map inserts of the time list it as "Optional US 176"; was downgraded to secondary roads. |
| US 176 Conn. | 0.520 | 0.837 | US 221 in Spartanburg | I-585 / US 176 / SC 9 in Spartanburg | — | — | Unsigned |
| US 176 Conn. | 0.360 | 0.579 | US 221 in Spartanburg | I-585 / US 176 / SC 9 north of Spartanburg | — | — | Unsigned |
| US 176 Bus. | — | — | US 176 in Union | US 176 in Union | 01958-01-011958 | 01990-01-011990 | Was routed along Pinckney Street and Thompson Boulevard; replaced by SC 18 |
| US 176 Conn. | 0.460 | 0.740 | US 176 / SC 18 Truck in Union | SC 18 / SC 18 Truck in Union | — | — | Unsigned; completely concurrent with SC 18 Truck |
| US 176 Conn. | 0.340 | 0.547 | SC 72 / Douglas Street in Whitmire | US 176 in Whitmire | — | — | Unsigned |
| US 178 Conn. | 0.180 | 0.290 | US 76 / SC 28 / SC 28 Bus. in Northlake | US 178 in Northlake | — | — | Unsigned |
| US 178 Bus. | 4.840 | 7.789 | US 25 / US 25 Bus. / US 178 / US 221 in Greenwood | US 25 / US 25 Bus. / US 178 / SC 72 in Greenwood | 01949-01-011949 | current | |
| US 178 Conn. | 0.190 | 0.306 | US 178 / SC 39 / SC 121 in Saluda | US 378 / SC 194 in Saluda | — | — | Unsigned |
| US 178 Bus. | 4.400 | 7.081 | US 21 / US 178 in Wilkinson Heights | US 178 in Orangeburg | 01970-01-011970 | current | |
| US 221 Truck | 5.440 | 8.755 | US 221 / SC 127 | US 76 / US 221 in Laurens | — | — | |
| US 221 Alt. | 5.360 | 8.626 | US 221 / SC 11 in Chesnee | US 221 Alt. at the North Carolina state line near State Line | 01941-01-011941 | current | |
| US 221 Conn. | 0.490 | 0.789 | US 221 / SC 11 east of Chesnee | US 221 east of Chesnee | — | — | Unsigned |
| US 276 Conn. | 1.100 | 1.770 | US 25 Conn. / US 276 in Travelers Rest | US 25 / US 25 Conn. in Travelers Rest | — | — | Unsigned; may be decommissioned |
| US 276 Bus. | — | — | US 25 / US 276 in Greenville | US 276 in Greenville | 01947-01-01c. 1947 | 01970-01-011970 | |
| US 276 Bus. | — | — | US 276 in Greenville | US 276 in Mauldin | 01983-01-011983 | 01984-01-011984 | |
| US 278 Conn. | 0.060 | 0.097 | US 278 / Town Square in Ridgeland | US 278 in Ridgeland | — | — | Unsigned |
| US 278 Bus. | 8.990 | 14.468 | US 278 in Hilton Head Island | US 278 / Greenwood Drive / Pope Avenue in Hilton Head Island | 01998-01-011998 | current | |
| US 301 Conn. | 0.410 | 0.660 | I-95 / US 521 in Alcolu | US 301 Conn. in Alcolu | — | — | Unsigned |
| US 301 Conn. | 2.470 | 3.975 | US 301 southeast of Alcolu | US 521 in Alcolu | — | — | Unsigned |
| US 321 Bus. | 4.350 | 7.001 | US 321 / SC 34 / SC 213 southwest of Winnsboro Mills | US 321 near Winnsboro | 01952-01-011952 | current | |
| US 321 Bus. | 3.670 | 5.906 | US 321 / SC 9 / SC 72 / SC 97 / SC 121 southeast of Chester | US 321 / SC 97 northwest of Chester | 01964-01-011964 | current | |
| US 321 Bus. | 2.500 | 4.023 | US 321 in York | US 321 / SC 161 Bus. in York | 01958-01-011958 | current | |
| US 378 Bus. | 6.6 | 10.6 | US 76 / US 378 northwest of Sumter | US 378 east of Sumter | 01958-01-011958 | 01975-01-011975 | Was routed along Broad Street, Liberty Street, and Myrtle Beach Boulevard |
| US 378 Bus. | 4.490 | 7.226 | US 378 / SC 341 northwest of Lake City | US 378 near Lake City | 01958-01-011958 | current | Routed along Main Street (with SC 341) and Church Street / Myrtle Beach Highway |
| US 378 Truck | 27.328 | 43.980 | US 378 / US 501 / US 701 in Conway | US 378 / US 701 / SC 905 in Conway | — | — | Routed along US 501, SC 544 Conn., US 501 Bus., SC 90, Old Reaves Ferry Road, and SC 905 |
| US 401 Bus. | 3.4 | 5.5 | US 401 in Bennettsville | US 401 in Bennettsville | 01958-01-011958 | 01989-01-011989 | Was routed along Main Street and Tyson Avenue, in concurrency with US 15 Bus. It was replaced by SC 385. |
| US 501 Bus. | 4.600 | 7.403 | US 501 in Red Hill | US 501 / US 701 in Conway | 01964-01-011964 | current | |
| US 501 Bus. | 7.210 | 11.603 | US 501 / SC 41 Alt. near Marion | US 501 north of Marion | 01964-01-011964 | current | |
| US 521 Bus. | 3.420 | 5.504 | US 521 southeast of Andrews | US 521 / SC 41 in Andrews | — | — | |
| US 521 Conn. | 4.7 | 7.6 | US 521 in Sumter | US 15 in Sumter | — | 02008-01-01c. 2008 | |
| US 521 Truck | 3.420 | 5.504 | US 1 Truck / US 521 in Camden | US 521 / US 601 / US 601 Truck in Camden | — | — | |
| US 521 Truck | 0.830 | 1.336 | US 1 Truck / US 521 / SC 34 Truck in Camden | US 1 / US 1 Truck / SC 34 / SC 34 Truck in Camden | — | — | Completely concurrent with US 1 Truck and SC 34 Truck |
| US 521 Bus. | 1.500 | 2.414 | US 521 / US 601 / US 601 Bus. in Kershaw | US 521 north of Kershaw | — | — | |
| US 521 Truck | 0.140 | 0.225 | US 521 / US 601 / SC 157 Truck / SC 341 Truck in Kershaw | US 521 / US 601 / US 601 Bus. / SC 157 Truck / SC 341 Truck in Kershaw | — | — | Completely concurrent with US 601 / SC 157 Truck / SC 341 Truck |
| US 521 Conn. | 0.060 | 0.097 | US 521 Bus. north of Kershaw | US 521 north of Kershaw | — | — | Unsigned |
| US 521 Bus. | 3.870 | 6.228 | US 521 northwest of Elgin | US 521 / SC 9 in Lancaster | 01965-01-011965 | current | |
| US 521 Byp. | — | — | US 521 northwest of Elgin | US 521 / SC 9 in Lancaster | — | — | |
| US 601 Truck | 5.2 | 8.4 | US 301 / US 601 / SC 4 in Orangeburg | US 21 / US 21 Bus. / US 178 / US 601 in Orangeburg | — | — | |
| US 601 Truck | 3.980 | 6.405 | US 1 / US 521 Truck / US 601 in Camden | US 521 / US 521 Truck / US 601 in Camden | — | — | |
| US 601 Bus. | 0.760 | 1.223 | US 521 / US 521 Bus. / US 601 in Kershaw | US 521 Bus. / US 521 Truck / US 601 / SC 157 Truck / SC 341 Truck in Kershaw | — | — | |
| US 701 Bus. | 4.2 | 6.8 | US 17 / US 17 Bus. / US 701 northwest of Mount Pleasant | US 17 / US 17 Bus. / US 701 northeast of Mount Pleasant | 01967-01-01c. 1967 | 01992-01-011992 | Was routed along Coleman Boulevard and Georgetown Highway (Chuck Dawley Boulevard) in concurrency with US 17 Bus. It was replaced by SC 703 and I-526 Bus. |
| US 701 Truck | 27.328 | 43.980 | US 378 / US 501 / US 701 in Conway | US 378 / US 701 / SC 905 in Conway | — | — | Routed along US 501, SC 544 Conn., US 501 Bus., SC 90, Old Reaves Ferry Road, and SC 905 |
| US 701 Truck | 1.468 | 2.363 | US 501 / US 501 Bus. / US 701 in Conway | US 701 / Sherwood Drive in Conway | — | — | Routed along US 501 and Mill Pond Road |
| US 701 Bus. | 0.179 | 0.288 | US 701 north of Loris | US 701 Bus. at the North Carolina state line north of Loris | 01960-01-011960 | current | Only business loop that crosses the North Carolina state line |
| Former ||||||||