# 2022 Murcia Open – Singles

Tallon Griekspoor was the defending champion but chose not to defend his title.
Tseng Chun-hsin won the title after defeating Norbert Gombos 6–4, 6–1 in the final.

## Seeds

* Norbert Gombos (final)
* Juan Manuel Cerúndolo (first round, retired)
* Dennis Novak (semifinals)
* Tseng Chun-hsin (champion)
* Mario Vilella Martínez (withdrew)
* Maximilian Marterer (first round)
* Marco Trungelliti (quarterfinals)
* Andrea Pellegrino (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Norbert Gombos | 1 | 6 | 7$^7$ | | | | |
| 3 | Dennis Novak | 6 | 1 | 6$^2$ | | | | |
| 3 | Dennis Novak | 6 | 1 | 6$^2$ | 1 | Norbert Gombos | 4 | 1 |
| | | | | | 4 | Tseng Chun-hsin | 6 | 6 |
| 4 | Tseng Chun-hsin | 6 | 6 | | 4 | Tseng Chun-hsin | 6 | 6 |
| WC | Ivan Gakhov | 4 | 4 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | N Gombos | 6 | 6 | | | | | | | | | | | | | | | | |
| | Em Nava | 4 | 4 | | 1 | N Gombos | 5 | 6 | 7$^7$ | | | | | | | | | | |
| | O Roca Batalla | 7 | 6 | | | O Roca Batalla | 7 | 3 | 6$^2$ | | | | | | | | | | |
| WC | C Sánchez Jover | 5 | 4 | | | | | | | 1 | N Gombos | 6 | 6 | | | | | | |
| | J Barranco Cosano | 4 | 6 | 6$^6$ | | | | | | 7 | M Trungelliti | 0 | 4 | | | | | | |
| Q | M Geerts | 6 | 3 | 7$^8$ | Q | M Geerts | 3 | 6 | 3 | | | | | | | | | | |
| | A Kuznetsov | 3 | 2$^r$ | | 7 | M Trungelliti | 6 | 3 | 6 | | | | | | | | | | |
| 7 | M Trungelliti | 6 | 5 | | | | | | | | | | | | 1 | N Gombos | 1 | 6 | 7$^7$ |
| 3 | D Novak | 6 | 7 | | | | | | | | | | | | 3 | D Novak | 6 | 1 | 6$^2$ |
| | F Misolic | 3 | 5 | | 3 | D Novak | 6 | 6 | | | | | | | | | | | |
| Q | U Blanch | 2 | 4 | | Q | M Damas | 0 | 2 | | | | | | | | | | | |
| Q | Miguel Damas | 6 | 6 | | | | | | | 3 | D Novak | 3 | 7$^7$ | 6 | | | | | |
| | N Kuhn | 6 | 2 | 1 | | | | | | WC | C Gimeno Valero | 6 | 6$^4$ | 3 | | | | | |
| WC | C Gimeno Valero | 3 | 6 | 6 | WC | C Gimeno Valero | 6 | 6 | | | | | | | | | | | |
| | A Shevchenko | 4 | 6$^2$ | | LL | C Heyman | 3 | 3 | | | | | | | | | | | |
| LL | Christopher Heyman | 6 | 7$^7$ | | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | M Marterer | 0 | 7$^7$ | 3 | | | | | | | | | | | | | |
| | P Cachin | 6 | 6$^4$ | 6 | | P Cachin | 6 | 6 | | | | | | | | | |
| | S Ofner | 3 | 3 | | | R Brancaccio | 1 | 3 | | | | | | | | | |
| | R Brancaccio | 6 | 6 | | | | | | | P Cachin | 6$^5$ | 3 | | | | | |
| | N Álvarez Varona | 6 | 3 | 4 | | | | | 4 | C-h Tseng | 7$^7$ | 6 | | | | | |
| Q | D Mérida | 2 | 6 | 6 | Q | D Mérida | 2 | 3 | | | | | | | | | |
| Q | O Krutykh | 3 | 3 | | 4 | C-h Tseng | 6 | 6 | | | | | | | | | |
| 4 | C-h Tseng | 6 | 6 | | | | | | | | | | | 4 | C-h Tseng | 6 | 6 |
| 8 | A Pellegrino | 3 | 6 | 3 | | | | | | | | | | WC | I Gakhov | 4 | 4 |
| | L Klein | 6 | 1 | 6 | | L Klein | 3 | 5 | | | | | | | | | |
| | J Forejtek | 7 | 6 | | | J Forejtek | 6 | 7 | | | | | | | | | |
| Q | R Molleker | 5 | 3 | | | | | | | J Forejtek | 6$^5$ | 6 | 5 | | | | |
| | L Giustino | 7$^7$ | 4 | 6 | | | | | WC | I Gakhov | 7$^7$ | 4 | 7 | | | | |
| | J Nikles | 6$^5$ | 6 | 4 | | L Giustino | 4 | 3 | | | | | | | | | |
| WC | I Gakhov | 3 | 7$^7$ | 2 | WC | I Gakhov | 6 | 6 | | | | | | | | | |
| 2 | JM Cerúndolo | 6 | 6$^3$ | 0$^r$ | | | | | | | | | | | | | |