# Circovirus

Circovirus is a genus of viruses, in the family Circoviridae. Birds (such as pigeons and ducks) and pigs serve as natural hosts, though dogs have been shown to be infected as well. It is a single stranded DNA virus (ssDNA). There are 49 species in this genus. Some members of this genus cause disease: PCV-1 is non pathogenic, while PCV-2 causes postweaning multisystemic wasting syndrome (PMWS).

## Taxonomy

The following species are recognized:
* Barbel circovirus
* Bat associated circovirus 1
* Bat associated circovirus 2
* Bat associated circovirus 3
* Bat associated circovirus 4
* Bat associated circovirus 5
* Bat associated circovirus 6
* Bat associated circovirus 7
* Bat associated circovirus 8
* Bat associated circovirus 9
* Bat associated circovirus 10
* Bat associated circovirus 11
* Bat associated circovirus 12
* Bat associated circovirus 13
* Beak and feather disease virus
* Bear circovirus
* Canary circovirus
* Canine circovirus
* Chimpanzee associated circovirus 1
* Civet circovirus
* Duck circovirus
* Elk circovirus
* European catfish circovirus
* Finch circovirus
* Goose circovirus
* Gull circovirus
* Human associated circovirus 1 (HCirV-1)
* Mink circovirus
* Mosquito associated circovirus 1
* Penguin circovirus
* Pigeon circovirus
* Porcine circovirus 1
* Porcine circovirus 2
* Porcine circovirus 3
* Porcine circovirus 4
* Raven circovirus
* Rodent associated circovirus 1
* Rodent associated circovirus 2
* Rodent associated circovirus 3
* Rodent associated circovirus 4
* Rodent associated circovirus 5
* Rodent associated circovirus 6
* Rodent associated circovirus 7
* Starling circovirus
* Swan circovirus
* Tick associated circovirus 1
* Tick associated circovirus 2
* Whale circovirus
* Zebra finch circovirus

## Structure

Viruses in Circovirus are non-enveloped, with icosahedrals capsids that have T=1 symmetry. The diameter is around 17 nm. Genomes are circular and non-segmented.
The virions of Circoviruses are surprisingly small, with diameters ranging from 17 up to 22 nm.
| Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
| Circovirus | Icosahedral | T=1 | Non-enveloped | Circular | Monopartite |

## Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by penetration. Replication follows the ssDNA rolling circle model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and nuclear pore export. Birds and pigs serve as the natural host. The virus is known to cause "immunosuppressive conditions" in animals that are infected; as well as having the ability to jump between species, creating difficulty in identifying the origin of infection. Transmission routes are fecal-oral and parental.
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
| Circovirus | Birds; pigs | None | Cell receptor endocytosis | Budding | Nucleus | Nucleus | Horizontal; oral-fecal |

## Genome

Circovirus has a monopartite, circular, and ssDNA genome of between 1759 and 2319nt, making it possibly the virus of shortest genome size in mammal viruses. The virus replicates through an dsDNA intermediate initiated by the Rep protein. Two major genes are transcribed from open reading frame (ORF) 1 and 2. ORF1 encodes Rep and Rep' for initiation of rolling-circle replication; ORF2 encodes Cap, the only structural and most immunogenic protein forming the viral capsid.