# 2010 Arizona Cardinals season

The 2010 season was the Arizona Cardinals' 91st in the National Football League (NFL) and their 23rd in Arizona. The Cardinals attempted to improve on their 10–6 record from 2009. But after a modest 3–2 start, the Cardinals fell apart by losing 9 of their remaining 11 contests. They were eliminated from postseason contention for the first time since 2007 in Week 15.

## Offseason

Quarterback Kurt Warner announced his retirement on January 29, 2010.

## 2010 NFL Draft

After finishing the season with a loss in the divisional round of the postseason, the Cardinals will pick 26th. The Cardinals will also have an additional third and fourth round pick from a trade that sent wide receiver Anquan Boldin to the Baltimore Ravens. Their fourth round pick was traded to the New York Jets for safety Kerry Rhodes.
Arizona Cardinals 2010 NFL Draft selections :
| Round | Selection | Player | Position | College |
| 1 | 26 | Dan Williams | DT | Tennessee |
| 2 | 47* | Daryl Washington | LB | Texas Christian |
| 3 | 88** | Andre Roberts | WR | Citadel |
| 4 | 130* | O'Brien Schofield | DE | University of Wisconsin |
| 5 | 155** | John Skelton | QB | Fordham |
| 6 | 201* | Jorrick Calvin | CB | Troy |
| 7 | 233 | Jim Dray | TE | Stanford |

## Preseason
### Schedule

| Week | Date | Opponent | Result | Record | Venue | Recap |
| 1 | August 14 | Houston Texans | W 19–16 | 1–0 | University of Phoenix Stadium | Recap |
| 2 | August 23 | at Tennessee Titans | L 10–24 | 1–1 | LP Field | Recap |
| 3 | August 28 | at Chicago Bears | W 14–9 | 2–1 | Soldier Field | Recap |
| 4 | September 2 | Washington Redskins | W 20–10 | 3–1 | University of Phoenix Stadium | Recap |

## Regular season

| Week | Date | Opponent | Result | Record | Venue | Recap |
| 1 | September 12 | at St. Louis Rams | W 17–13 | 1–0 | Edward Jones Dome | Recap |
| 2 | September 19 | at Atlanta Falcons | L 7–41 | 1–1 | Georgia Dome | Recap |
| 3 | September 26 | Oakland Raiders | W 24–23 | 2–1 | University of Phoenix Stadium | Recap |
| 4 | October 3 | at San Diego Chargers | L 10–41 | 2–2 | Qualcomm Stadium | Recap |
| 5 | October 10 | New Orleans Saints | W 30–20 | 3–2 | University of Phoenix Stadium | Recap |
| 6 | Bye | Bye | Bye | Bye | Bye | Bye |
| 7 | October 24 | at Seattle Seahawks | L 10–22 | 3–3 | Qwest Field | Recap |
| 8 | October 31 | Tampa Bay Buccaneers | L 35–38 | 3–4 | University of Phoenix Stadium | Recap |
| 9 | November 7 | at Minnesota Vikings | L 24–27 (OT) | 3–5 | Mall of America Field | Recap |
| 10 | November 14 | Seattle Seahawks | L 18–36 | 3–6 | University of Phoenix Stadium | Recap |
| 11 | November 21 | at Kansas City Chiefs | L 13–31 | 3–7 | Arrowhead Stadium | Recap |
| 12 | November 29 | San Francisco 49ers | L 6–27 | 3–8 | University of Phoenix Stadium | Recap |
| 13 | December 5 | St. Louis Rams | L 6–19 | 3–9 | University of Phoenix Stadium | Recap |
| 14 | December 12 | Denver Broncos | W 43–13 | 4–9 | University of Phoenix Stadium | Recap |
| 15 | December 19 | at Carolina Panthers | L 12–19 | 4–10 | Bank of America Stadium | Recap |
| 16 | December 25 | Dallas Cowboys | W 27–26 | 5–10 | University of Phoenix Stadium | Recap |
| 17 | January 2 | at San Francisco 49ers | L 7–38 | 5–11 | Candlestick Park | Recap |

## Standings

NFC West :
| viewtalkedit | W | L | T | PCT | DIV | CONF | PF | PA | STK |
| $^{(4)}$ Seattle Seahawks | 7 | 9 | 0 | .438 | 4–2 | 6–6 | 310 | 407 | W1 |
| St. Louis Rams | 7 | 9 | 0 | .438 | 3–3 | 5–7 | 289 | 328 | L1 |
| San Francisco 49ers | 6 | 10 | 0 | .375 | 4–2 | 4–8 | 305 | 346 | W1 |
| Arizona Cardinals | 5 | 11 | 0 | .313 | 1–5 | 3–9 | 289 | 434 | L1 |

## Regular season results
### Week 1: at St. Louis Rams

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 0 | 10 | 0 | 7 | 17 |
| Rams | 0 | 10 | 3 | 0 | 13 |
at Edward Jones Dome, St. Louis, Missouri
* Date: September 12
* Game time: 3:15 p.m. CDT/1:15 p.m. MST
* Game weather: None (indoor stadium)
* Game attendance: 52,440
* Referee: Alberto Riveron
* TV announcers (Fox): Ron Pitts, John Lynch and Nischelle Turner
* Box Score
Game information :
First quarter
No scoring plays
Second quarter
ARI – Jay Feely 22-yard field goal, 13:54. Cardinals 3–0. Drive: 10 plays, 56 yards, 4:01.
STL – Josh Brown 46-yard field goal, 5:28. Tied 3–3. Drive: 8 plays, 44 yards, 4:36.
ARI – Tim Hightower 1-yard run (Jay Feely kick), 2:54. Cardinals 10–3. Drive: 5 plays, 76 yards, 2:34.
STL – Laurent Robinson 1-yard pass from Sam Bradford (Josh Brown kick), 0:00. Tied 10–10. Drive: 8 plays, 63 yards, 1:20.
Third quarter
STL – Josh Brown 25-yard field goal, 8:28. Rams 13–10. Drive: 7 plays, 31 yards, 3:26.
Fourth quarter
ARI – Larry Fitzgerald 21-yard pass from Derek Anderson (Jay Feely kick), 6:13. Cardinals 17–13. Drive: 7 plays, 86 yards, 3:56.
Top passers
ARI – Derek Anderson – 22/41, 297 yards, TD
STL – Sam Bradford – 32/55, 253 yards, TD, 3 INT
Top rushers
ARI – Tim Hightower – 13 rushes, 54 yards, TD
STL – Steven Jackson – 22 rushes, 81 yards
Top receivers
ARI – Steve Breaston – 7 receptions, 132 yards
STL – Mark Clayton – 10 receptions, 119 yards :
The Cardinals began their season at the Edward Jones Dome for an NFC West match against the St. Louis Rams. The Cardinals scored first in the 2nd quarter with kicker Jay Feely nailing a 22-yard field goal, which was replied by St. Louis when kicker Josh Brown made a 46-yard field goal. Arizona took the lead again with running back Tim Hightower making a 1-yard TD run, but failed to maintain it, with quarterback Sam Bradford making a 1-yard TD pass to wide receiver Laurent Robinson. In the third quarter, the Cardinals trailed for the first time when Brown nailed a 25-yard field goal, which they overcame in the fourth quarter when quarterback Derek Anderson made a 21-yard touchdown pass to wide receiver Larry Fitzgerald, giving Arizona a win.
With the win, Arizona began the season at 1–0.

### Week 2: at Atlanta Falcons

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 0 | 7 | 0 | 0 | 7 |
| Falcons | 7 | 17 | 10 | 7 | 41 |
at Georgia Dome, Atlanta, Georgia
* Date: September 19
* Game time: 1:00 p.m. EDT/10:00 a.m. MST
* Game weather: None (indoor stadium)
* Game attendance: 66,824
* Referee: Jerome Boger
* TV announcers (Fox): Thom Brennaman, Brian Billick and Charissa Thompson
* Box Score
Game information :
First quarter
ATL – Roddy White 7-yard pass from Matt Ryan (Matt Bryant kick), 10:33. Falcons 7–0. Drive: 9 plays, 70 yards, 4:27.
Second quarter
ATL – Matt Bryant 24-yard field goal, 13:06. Falcons 10–0. Drive: 6 plays, 37 yards, 3:24.
ARI – Tim Hightower 80-yard run (Jay Feely kick), 12:54. Falcons 10–7. Drive: 1 play, 80 yards, 0:12.
ATL – Jason Snelling 19-yard pass from Matt Ryan (Matt Bryant kick), 9:18. Falcons 17–7. Drive: 9 plays, 72 yards, 3:36.
ATL – Jason Snelling 1-yard run (Matt Bryant kick), 3:31. Falcons 24–7. Drive: 8 plays, 78 yards, 3:58.
Third quarter
ATL – Brian Finneran 12-yard pass from Matt Ryan (Matt Bryant kick), 13:18. Falcons 31–7. Drive: 3 plays, 14 yards, 0:45.
ATL – Matt Bryant 35-yard field goal, 3:57. Falcons 34–7. Drive: 16 plays, 69 yards, 6:37.
Fourth quarter
ATL – Jason Snelling 7-yard run (Matt Bryant kick), 3:05. Falcons 41–7. Drive: 11 plays, 80 yards, 6:41.
Top passers
ARI – Derek Anderson – 17/31, 161 yards, 2 INT
ATL – Matt Ryan – 21/32, 225 yards, 3 TD
Top rushers
ARI – Tim Hightower – 11 rushes, 115 yards, TD
ATL – Jason Snelling – 24 rushes, 129 yards, 2 TD
Top receivers
ARI – Larry Fitzgerald – 7 receptions, 83 yards
ATL – Roddy White – 7 receptions, 78 yards, TD :
Hoping to maintain their current winning streak the Cardinals flew to Georgia Dome for an NFC duel with the Falcons. In the first quarter Arizona trailed early as QB Matt Ryan completed a 7-yard TD pass to WR Roddy White, followed in the second quarter by kicker Matt Bryant hitting a 24-yard field goal. Arizona would reply with RB Tim Hightower getting an 80-yard TD run, but fell further behind when Ryan threw a 19-yard TD pass to FB Jason Snelling, followed by Snelling getting a 1-yard TD run. In the third quarter the Cardinals struggled further when Ryan completed a 12-yard touchdown pass to WR Brian Finneran, followed by Bryan nailing a 35-yard field goal. In the fourth quarter Arizona continued to struggle with FB Jason Snelling getting a 7-yard TD run.
With the loss, the Cardinals fell to 1–1.

### Week 3: vs. Oakland Raiders

| Quarter | 1 | 2 | 3 | 4 | Total |
| Raiders | 13 | 7 | 0 | 3 | 23 |
| Cardinals | 10 | 7 | 7 | 0 | 24 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: September 26
* Game time: 1:15 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 62,439
* Referee: Mike Carey
* TV announcers (CBS): Spero Dedes and Randy Cross
* Box Score
Game information :
First quarter
ARI – LaRod Stephens-Howling 102-yard kickoff return (Jay Feely kick), 14:46. Cardinals 7–0.
OAK – Zach Miller 22-yard pass from Bruce Gradkowski (Sebastian Janikowski kick), 10:54. Tied 7–7. Drive: 3 plays, 59 yards, 0:52.
OAK – Sebastian Janikowski 22-yard field goal, 6:42. Raiders 10–7. Drive: 5 plays, 24 yards, 1:22.
ARI – Jay Feely 42-yard field goal, 3:55. Tied 10–10. Drive: 6 plays, 25 yards, 2:01.
OAK – Sebastian Janikowski 54-yard field goal, 1:54. Raiders 13–10. Drive: 7 plays, 48 yards, 3:16.
Second quarter
ARI – Steve Breaston 2-yard pass from Derek Anderson (Jay Feely kick), 10:44. Cardinals 17–13. Drive: 12 plays, 76 yards, 6:10.
OAK – Darren McFadden 2-yard run (Sebastian Janikowski kick), 0:10. Raiders 20–17. Drive: 7 plays, 69 yards, 2:30.
Third quarter
ARI – Larry Fitzgerald 8-yard pass from Derek Anderson (Jay Feely kick), 1:01. Cardinals 24–20. Drive: 7 plays, 69 yards, 4:02.
Fourth quarter
OAK – Sebastian Janikowski 23-yard field goal, 7:59. Cardinals 24–23. Drive: 8 plays, 11 yards, 3:39.
Top passers
OAK – Bruce Gradkowski – 17/34, 255 yards, TD, INT
ARI – Derek Anderson – 12/26, 122 yards, 2 TD, INT
Top rushers
OAK – Darren McFadden – 25 rushes, 105 yards, TD
ARI – Beanie Wells – 14 rushes, 75 yards
Top receivers
OAK – Louis Murphy – 5 receptions, 119 yards
ARI – Steve Breaston – 4 receptions, 41 yards, TD :
The Cardinals' third game was an Interconference duel with the Raiders. The Cardinals led early in the first quarter when RB LaRod Stephens-Howling returned a kickoff from his own goal line to the endzone running 102 yards for a touchdown. The Raiders replied and took the lead with QB Bruce Gradkowski completing a 22-yard touchdown pass to TE Zach Miller, followed by kicker Sebastian Janikowski making a 22-yard field goal. Arizona replied with kicker Jay Feely kicking a 42-yard field goal. Then the Raiders replied with Janikowski making a 54-yard field goal. The Cardinals took the lead in the 2nd quarter when QB Derek Anderson made a 2-yard TD pass to WR Steve Breaston, but it didn't last very long after RB Darren McFadden got a 2-yard TD run. Arizona got the lead back in the 3rd quarter when Anderson found WR Larry Fitzgerald on an 8-yard TD pass. In the 4th quarter Oakland cut the lead when Janikowski made a 23-yard field goal. Janikowski missed three field goals in the game, giving Arizona the win.
With the close win, Arizona improved to 2–1.

### Week 4: at San Diego Chargers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 0 | 7 | 0 | 3 | 10 |
| Chargers | 7 | 21 | 10 | 3 | 41 |
at Qualcomm Stadium, San Diego, California
* Date: October 3
* Game time: 1:15 p.m. MST & PDT
* Game weather: Sunny, 72 °F (22 °C)
* Game attendance: 62,189
* Referee: Gene Steratore
* TV announcers (Fox): Sam Rosen, Tim Ryan and Chris Myers
* Box Score
Game information :
First quarter
SD – Antonio Gates 33-yard pass from Philip Rivers (Nate Kaeding kick), 4:45. Chargers 7–0. Drive: 8 plays, 89 yards, 4:45.
Second quarter
ARI – Kerry Rhodes 42-yard fumble return (Jay Feely kick), 13:34. Tied 7–7.
SD – Mike Tolbert 5-yard run (Nate Kaeding kick), 10:31. Chargers 14–7. Drive: 5 plays, 63 yards, 3:03.
SD – Antonio Gates 26-yard pass from Philip Rivers (Nate Kaeding kick), 3:30. Chargers 21–7. Drive: 9 plays, 65 yards, 4:14.
SD – Shaun Phillips 31-yard interception return (Nate Kaeding kick), 2:30. Chargers 28–7.
Third quarter
SD – Nate Kaeding 48-yard field goal, 3:55. Chargers 31–7. Drive: 6 plays, 32 yards, 3:41.
SD – Ryan Matthews 15-yard run (Nate Kaeding kick), 1:31. Chargers 38–7. Drive: 1 play, 15 yards, 0:07.
Fourth quarter
SD – Nate Kaeding 47-yard field goal, 10:49. Chargers 41–7. Drive: 8 plays, 35 yards, 4:11.
ARI – Jay Feely 53-yard field goal, 3:17. Chargers 41–10. Drive: 8 plays, 29 yards, 4:05.
Top passers
ARI – Max Hall – 8/14, 82 yards
SD – Philip Rivers – 15/20, 241 yards, 2 TD
Top rushers
ARI – Tim Hightower – 7 rushes, 24 yards
SD – Mike Tolbert – 16 rushes, 100 yards, TD
Top receivers
ARI – Larry Fitzgerald – 7 receptions, 56 yards
SD – Antonio Gates – 7 receptions, 144 yards, 2 TD :
Hoping to increase their winning streak the Cardinals flew to Qualcomm Stadium for an interconference duel with the Chargers. In the 1st quarter the Cardinals trailed early as QB Philip Rivers completed a 33-yard TD pass to TE Antonio Gates, but they replied in the 2nd quarter when FS Kerry Rhodes recovered a fumble and ran 2 yards to the endzone for a touchdown. After that, the Cardinals fell further behind with FB Mike Tolbert making a 5-yard TD run, followed by Rivers making a 26-yard TD pass to TE Antonio Gates. The Cardinals had more problems when QB Derek Anderson's pass was intercepted by OLB Shaun Phillips which converted into a 31-yard touchdown run. This was followed in the 3rd quarter by kicker Nate Kaeding making a 48-yard field goal. Then RB Ryan Mathews got a 15-yard TD run. This was followed in the 4th quarter by Kaeding nailing a 47-yard field goal. The Cardinals tried to cut the lead, but only came away with kicker Jay Feely's 53-yard field goal, which isn't enough for the win.
With the loss, Arizona fell to 2–2.

### Week 5: vs. New Orleans Saints

| Quarter | 1 | 2 | 3 | 4 | Total |
| Saints | 10 | 3 | 0 | 7 | 20 |
| Cardinals | 0 | 10 | 3 | 17 | 30 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: October 10
* Game time: 1:05 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 62,621
* Referee: Tony Corrente
* TV announcers (Fox): Chris Rose and Kurt Warner
* Box Score
Game information :
First quarter
NO – John Carney 31-yard field goal, 9:49. Saints 3–0. Drive: 7 plays, 36 yards, 3:07.
NO – Jeremy Shockey 1-yard pass from Drew Brees (John Carney kick), 1:30. Saints 10–0. Drive: 11 plays, 76 yards, 5:32.
Second quarter
ARI – Jay Feely 37-yard field goal, 11:15. Saints 10–3. Drive: 10 plays, 31 yards, 5:15.
ARI – Levi Brown 2-yard fumble return (Jay Feely kick), 2:19. Tied 10–10.
NO – John Carney 32-yard field goal, 1:10. Saints 13–10. Drive: 6 plays, 58 yards, 1:09.
Third quarter
ARI – Jay Feely 44-yard field goal, 9:04. Tied 13–13. Drive: 7 plays, 34 yards, 4:17.
Fourth quarter
ARI – Jay Feely 29-yard field goal, 11:39. Cardinals 16–13. Drive: 10 plays, 69 yards, 4:48.
ARI – Kerry Rhodes 27-yard fumble return (Jay Feely kick), 10:39. Cardinals 23–13.
NO – Robert Meachem 35-yard pass from Drew Brees (John Carney kick), 1:49. Cardinals 23–20. Drive: 7 plays, 80 yards, 1:36.
ARI – Dominique Rodgers-Cromartie 28-yard interception return (Neil Rackers kick), 0:10. Cardinals 30–20.
Top passers
NO – Drew Brees – 24/39, 279 yards, 2 TD, 3 INT
ARI – Max Hall – 17/27, 168 yards, INT
Top rushers
NO – Ladell Betts – 10 rushes, 44 yards
ARI – Beanie Wells – 20 rushes, 35 yards
Top receivers
NO – Marques Colston – 7 receptions, 97 yards
ARI – Larry Fitzgerald – 7 receptions, 93 yards :
Hoping to rebound from their loss to the Chargers the Cardinals played on home ground for an NFC duel with the Saints. In the first quarter the Cardinals trailed early as kicker John Carney nailed a 31-yard field goal, followed by QB Drew Brees completing a 1-yard TD pass to TE Jeremy Shockey. The Cardinals replied with kicker Jay Feely making a 37-yard field goal, followed by OT Levi Brown recovering a fumble and returning it 2 yards for a touchdown. In the third quarter the Cardinals replied and took the lead when Feely got a 44-yard field goal, followed the 4th quarter by Feely's 29-yard field goal. Then FS Kerry Rhodes recovered a fumble and ran 27 yards to the endzone for a touchdown. The lead was broken down with Brees making a 35-yard TD pass to WR Robert Meachem, but the Cardinals managed to pull away when Brees' pass was intercepted by CB Dominique Rodgers-Cromartie and returned 28 yards to the endzone for a touchdown.
With the win, Arizona went into their bye week at 3–2.

### Week 7: at Seattle Seahawks

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 0 | 0 | 7 | 3 | 10 |
| Seahawks | 3 | 7 | 9 | 3 | 22 |
at Qwest Field, Seattle, Washington
* Date: October 24
* Game time: 1:05 p.m. MST & PDT
* Game weather: Cloudy, 52 °F (11 °C)
* Game attendance: 67,132
* Referee: Jeff Triplette
* TV announcers (Fox): Chris Myers, Brian Billick and Charissa Thompson
* Box Score
Game information :
First quarter
SEA – Olindo Mare 20-yard field goal, 7:29. Seahawks 3–0. Drive: 14 plays, 78 yards, 7:31.
Second quarter
SEA – Mike Williams 2-yard pass from Matt Hasselbeck (Olindo Mare kick), 5:46. Seahawks 10–0. Drive: 2 plays, 2 yards, 0:09.
Third quarter
SEA – Olindo Mare 31-yard field goal, 12:11. Seahawks 13–0. Drive: 4 plays, -2 yards, 1:55.
SEA – Olindo Mare 51-yard field goal, 10:57. Seahawks 16–0. Drive: 4 plays, -17 yards, 1:14.
ARI – Beanie Wells 2-yard run (Jay Feely kick), 5:43. Seahawks 16–7. Drive: 8 plays, 70 yards, 5:14.
SEA – Olindo Mare 24-yard field goal, 0:49. Seahawks 19–7. Drive: 14 plays, 78 yards, 4:54.
Fourth quarter
ARI – Jay Feely 24-yard field goal, 14:48. Seahawks 19–10. Drive: 5 plays, 27 yards, 1:01.
SEA – Olindo Mare 26-yard field goal, 7:28. Seahawks 22–10. Drive: 12 plays, 57 yards, 7:20.
Top passers
ARI – Derek Anderson – 8/17, 96 yards
SEA – Matt Hasselbeck – 20/38, 192 yards, TD
Top rushers
ARI – Tim Hightower – 6 rushes, 59 yards
SEA – Marshawn Lynch – 24 rushes, 89 yards
Top receivers
ARI – Andre Roberts – 2 receptions, 40 yards
SEA – Mike Williams – 11 receptions, 87 yards, TD :
Coming off their bye week the Cardinals flew to Qwest Field for an NFC West rivalry match against the Seahawks. In the first quarter the Cardinals trailed early as kicker Olindo Mare got a 20-yard field goal. Followed in the second quarter by QB Matt Hasselbeck making a 2-yard TD pass to WR Mike Williams. The Cardinals fell further behind in the 3rd quarter with Mare nailing a 31 and a 51-yard field goal. The Cardinals replied with RB Beanie Wells getting a 2-yard TD run. The Seahawks continued to score with Mare hitting a 24-yard field goal, but the Cardinals responded in the fourth quarter with kicker Jay Feely getting a 24-yard field goal. The Seahawks pulled away with Mare making a 26-yard field goal.
With the loss, the Cardinals fell to 3–3.

### Week 8: vs. Tampa Bay Buccaneers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Buccaneers | 7 | 17 | 7 | 7 | 38 |
| Cardinals | 7 | 7 | 14 | 7 | 35 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: October 31
* Game time: 1:15 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 61,857
* Referee: Ron Winter
* TV announcers (Fox): Chris Myers, Brian Billick and Jaime Maggio
* Box Score
Game information :
First quarter
ARI – Larry Fitzgerald 3-yard pass from Max Hall (Jay Feely kick), 6:25. Cardinals 7–0. Drive: 9 plays, 61 yards, 4:38.
TB – Geno Hayes 41-yard interception return (Connor Barth kick), 4:15. Tied 7–7.
Second quarter
ARI – Beanie Wells 1-yard run (Jay Feely kick), 10:17. Cardinals 14–7. Drive: 4 plays, 16 yards, 2:03.
TB – Mike Williams 47-yard pass from Josh Freeman (Connor Barth kick), 8:59. Tied 14–14. Drive: 3 plays, 80 yards, 1:18.
TB – Aqib Talib 45-yard interception return (Connor Barth kick), 6:33. Buccaneers 21–14.
TB – Connor Barth 21-yard field goal, 0:00. Buccaneers 24–14. Drive: 12 plays, 94 yards, 3:15.
Third quarter
TB – LeGarrette Blount 15-yard run (Connor Barth kick), 4:35. Buccaneers 31–14. Drive: 8 plays, 80 yards, 4:47.
ARI – LaRod Stephens-Howling 30-yard run (Jay Feely kick), 0:56. Buccaneers 31–21. Drive: 7 plays, 76 yards, 3:36.
ARI – Gerald Hayes 21-yard fumble return (Jay Feely kick), 0:33. Buccaneers 31–28.
Fourth quarter
ARI – Larry Fitzgerald 5-yard pass from Derek Anderson (Jay Feely kick), 9:41. Cardinals 35–31. Drive: 4 plays, 48 yards, 1:56.
TB – LaGarrette Blount 1-yard run (Connor Barth kick), 5:13. Buccaneers 38–35. Drive: 7 plays, 74 yards, 4:28.
Top passers
TB – Josh Freeman – 18/25, 278 yards, TD
ARI – Derek Anderson – 16/24, 234 yards, TD, 2 INT
Top rushers
TB – LaGarrette Blount – 22 rushes, 120 yards, 2 TD
ARI – Beanie Wells – 16 rushes, 50 yards, TD
Top receivers
TB – Mike Williams – 4 receptions, 105 yards, TD
ARI – Steve Breaston – 8 receptions, 147 yards :
The Cardinals' seventh game was an NFC duel with the Buccaneers at University of Phoenix Stadium. In the first quarter the Cardinals took the lead when QB Max Hall made a 3-yard TD pass to WR Larry Fitzgerald. The Buccaneers replied with OLB Geno Hayes returning an interception 41 yards for a touchdown. The Cardinals led again in the second quarter with RB Beanie Wells getting a 1-yard TD run, but the Buccaneers went on a scoring rally with QB Josh Freeman making a 47-yard TD pass to WR Mike Williams, and CB Aqib Talib returning an interception 45 yards for a touchdown. This was followed by kicker Connor Barth hitting a 21-yard field goal, and in the third quarter with RB LeGarrette Blount getting a 15-yard TD run. The Cardinals also went on a rally to take the lead back with RB LaRod Stephens-Howling making a 30-yard TD run, which was followed by ILB Gerald Hayes recovering a fumble and running 21 yards to the endzone for a touchdown. Then QB Derek Anderson found Fitzgerald on a 5-yard TD pass. The Buccaneers scored once more to take the win with Blount getting a 1-yard TD run.
With the loss, Arizona recorded back to back losses for the first time since the 2008 season, and fell to 3–4.

### Week 9: at Minnesota Vikings

| Quarter | 1 | 2 | 3 | 4 | OT | Total |
| Cardinals | 0 | 14 | 7 | 3 | 0 | 24 |
| Vikings | 0 | 10 | 0 | 14 | 3 | 27 |
at Mall of America Field at Hubert H. Humphrey Metrodome, Minneapolis, Minnesota
* Date: November 7
* Game time: 12:05 p.m. CST/11:05 a.m. MST
* Game weather: None (indoor stadium)
* Game attendance: 64,120
* Referee: Bill Leavy
* TV announcers (Fox): Kenny Albert, Daryl Johnston and Tony Siragusa
* Box Score
Game information :
First quarter
No scoring plays
Second quarter
MIN – Adrian Peterson 12-yard pass from Brett Favre (Ryan Longwell kick), 12:17. Vikings 7–0. Drive: 5 plays, 52 yards, 2:43.
ARI – LaRod Stephens-Howling 96-yard kickoff return (Jay Feely kick), 12:04. Tied 7–7.
MIN – Ryan Longwell 21-yard field goal, 6:22. Vikings 10–7. Drive: 11 plays, 61 yards, 5:42.
ARI – Andre Roberts 30-yard pass from Derek Anderson (Jay Feely kick), 0:29. Cardinals 14–10. Drive: 7 plays, 81 yards, 1:01.
Third quarter
ARI – Michael Adams 30-yard fumble return (Jay Feely kick), 14:48. Cardinals 21–10.
Fourth quarter
ARI – Jay Feely 22-yard field goal, 12:40. Cardinals 24–10. Drive: 14 plays, 89 yards, 7:36.
MIN – Adrian Peterson 4-yard run (Ryan Longwell kick), 3:34. Cardinals 24–17. Drive: 3 plays, 40 yards, 1:05.
MIN – Visanthe Shiancoe 25-yard pass from Brett Favre (Ryan Longwell kick), 0:27. Tied 24–24. Drive: 5 plays, 77 yards, 1:57.
Overtime
MIN – Ryan Longwell 35-yard field goal, 9:42. Vikings 27–24. Drive: 6 plays, 51 yards, 3:56.
Top passers
ARI – Derek Anderson – 15/26, 179 yards, TD
MIN – Brett Favre – 36/47, 446 yards, 2 TD, 2 INT
Top rushers
ARI – Tim Hightower – 13 rushes, 39 yards
MIN – Adrian Peterson – 15 rushes, 81 yards, TD
Top receivers
ARI – Larry Fitzgerald – 7 receptions, 107 yards
MIN – Percy Harvin – 9 receptions, 126 yards :
Hoping to snap their current losing streak the Cardinals flew to Hubert H. Humphrey Metrodome for an NFC duel with the Vikings. In the second quarter the Cardinals trailed early as QB Brett Favre got a 12-yard TD pass to RB Adrian Peterson. They immediately replied with a 96-yard kickoff return for a touchdown by RB LaRod Stephens-Howling. The Vikings responded with kicker Ryan Longwell nailing a 21-yard field goal. The Cardinals replied a took the lead with QB Derek Anderson completing a 30-yard TD pass to WR Andre Roberts. This was followed by DB Michael Adams returning a fumble 30 yards for a touchdown, and with kicker Jay Feely making a 22-yard field goal. The lead was closed down by Peterson as he got a 4-yard TD run, and by QB Brett Favre's 25-yard TD pass to TE Visanthe Shiancoe. After overtime the decision was made when Longwell successfully made a 35-yard field goal to give the Cardinals a loss, bringing their record down to 3–5.

### Week 10: vs. Seattle Seahawks

| Quarter | 1 | 2 | 3 | 4 | Total |
| Seahawks | 7 | 10 | 9 | 10 | 36 |
| Cardinals | 7 | 3 | 0 | 8 | 18 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: November 15
* Game time: 2:15 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 61,904
* Referee: Scott Green
* TV announcers (Fox): Thom Brennamen and Brian Billick
* Box Score
Game information :
First quarter
ARI – Tim Hightower 2-yard run (Jay Feely kick), 12:48. Cardinals 7–0. Drive: 6 plays, 99 yards, 2:32.
SEA – Marshawn Lynch 1-yard run (Olindo Mare kick), 7:44. Tied 7–7. Drive: 12 plays, 77 yards, 5:04.
Second quarter
SEA – Olindo Mare 41-yard field goal, 13:23. Seahawks 10–7. Drive: 8 plays, 67 yards, 3:18.
ARI – Jay Feely 23-yard field goal, 8:11. Tied 10–10. Drive: 8 plays, 71 yards, 1:09.
SEA – Deon Butler 63-yard pass from Matt Hasselbeck (Olindo Mare kick), 7:28. Seahawks 17–10. Drive: 2 plays, 80 yards, 0:43.
Third quarter
SEA – Olindo Mare 34-yard field goal, 7:05. Seahawks 20–10. Drive: 10 plays, 64 yards, 4:52.
SEA – Olindo Mare 19-yard field goal, 4:50. Seahawks 23–10. Drive: 6 plays, 31 yards, 2:02.
SEA – Olindo Mare 23-yard field goal, 1:15. Seahawks 26–10. Drive: 6 plays, 12 yards, 2:45.
Fourth quarter
SEA – Olindo Mare 19-yard field goal, 12:18. Seahawks 29–10. Drive: 7 plays, 10 yards, 2:55.
ARI – Early Doucet 2-yard pass from Derek Anderson (Derek Anderson–Larry Fitzgerald pass), 7:52. Seahawks 29–18. Drive: 6 plays, 85 yards, 3:14.
SEA – Justin Forsett 4-yard run (Olindo Mare kick), 3:49. Seahawks 36–18. Drive: 3 plays, 10 yards, 0:59.
Top passers
SEA – Matt Hasselbeck – 22/34, 333 yards, TD
ARI – Derek Anderson – 23/45, 322 yards, TD, INT
Top rushers
SEA – Justin Forsett – 9 rushes, 64 yards, TD
ARI – Tim Hightower – 13 rushes, 39 yards, TD
Top receivers
SEA – Mike Williams – 11 receptions, 145 yards
ARI – Steve Breaston – 4 receptions, 98 yards :
The Cardinals' ninth game was an NFC West rivalry re-match against the Seahawks. In the first quarter the Cardinals took the early lead as RB Tim Hightower got a 2-yard TD run. The Seahawks replied with RB Marshawn Lynch getting a 1-yard TD run. The Cardinals trailed with kicker Olindo Mare getting a 41-yard field goal, but they answed back with kicker Jay Feely nailing a 23-yard field goal. The Cardinals struggled further with QB Matt Hasselbeck completing a 63-yard TD pass to WR Deon Butler. This was followed in the third quarter by a 34, 19 and 23-yard field goal from Mare. In the fourth quarter Mare got another 19-yard field goal to put the Seahawks up 29–10. The Cardinals responded with QB Derek Anderson making a 2-yard TD pass to WR Early Doucet (With a successful 2-point conversion as Anderson found WR Larry Fitzgerald), but the Seahawks put the game away with RB Justin Forsett getting a 4-yard TD run.
With the loss, Arizona fell to 3–6.

### Week 11: at Kansas City Chiefs

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 3 | 0 | 3 | 7 | 13 |
| Chiefs | 0 | 14 | 7 | 10 | 31 |
at Arrowhead Stadium, Kansas City, Missouri
* Date: November 21
* Game time: 12:00 p.m. CST/11:00 a.m. MST
* Game weather: Cloudy, 66 °F (19 °C)
* Game attendance: 66,247
* Referee: Walt Coleman
* TV announcers (Fox): Ron Pitts and John Lynch
* Box Score
Game information :
First quarter
ARI – Jay Feely 36-yard field goal, 10:24. Cardinals 3–0. Drive: 9 plays, 51 yards, 4:36.
Second quarter
KC – Dwayne Bowe 1-yard pass from Matt Cassel (Ryan Succop kick), 13:35. Chiefs 7–3. Drive: 4 plays, 38 yards, 1:58.
KC – Thomas Jones 1-yard run (Ryan Succop kick), 10:14. Chiefs 14–3. Drive: 5 plays, 68 yards, 2:12.
Third quarter
KC – Thomas Jones 3-yard run (Ryan Succop kick), 9:59. Chiefs 21–3. Drive: 9 plays, 80 yards, 5:01.
ARI – Jay Feely 29-yard field goal, 4:55. Chiefs 21–6. Drive: 10 plays, 69 yards, 5:04.
Fourth quarter
KC – Ryan Succop 23-yard field goal, 8:12. Chiefs 24–6. Drive: 10 plays, 57 yards, 5:23.
KC – Dwayne Bowe 38-yard pass from Matt Cassel (Ryan Succop kick), 4:20. Chiefs 31–6. Drive: 3 plays, 42 yards, 1:19.
ARI – Larry Fitzgerald 3-yard pass from Derek Anderson (Jay Feely kick), 0:00. Chiefs 31–13. Drive: 14 plays, 83 yards, 4:20.
Top passers
ARI – Derek Anderson – 25/46, 295 yards, TD
KC – Matt Cassel – 15/24, 193 yards, 2 TD
Top rushers
ARI – Tim Hightower – 12 rushes, 62 yards
KC – Jamaal Charles – 12 rushes, 88 yards
Top receivers
ARI – Steve Breaston – 5 receptions, 92 yards
KC – Dwayne Bowe – 6 receptions, 109 yards, 2 TD :
Hoping to break their current losing streak the Cardinals flew to Arrowhead Stadium for an interconference duel with the Chiefs. The Cardinals scored with kicker Jay Feely hitting a 36-yard field goal, but they fell behind with QB Matt Cassel completing a 1-yard TD pass to WR Dwayne Bowe. This was followed by RB Thomas Jones getting a 1 and a 3-yard TD run. The Cardinals responded with Feely making a 29-yard field goal, but they struggled further with kicker Ryan Succop getting a 23-yard field goal, followed by Cassel throwing a 38-yard TD pass to Bowe. The Cardinals cut the lead with QB Derek Anderson completing a 3-yard TD pass to WR Larry Fitzgerald.
With the loss, the Cardinals fell to 3–7.

### Week 12: vs. San Francisco 49ers

| Quarter | 1 | 2 | 3 | 4 | Total |
| 49ers | 14 | 7 | 3 | 3 | 27 |
| Cardinals | 3 | 3 | 0 | 0 | 6 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: November 29
* Game time: 6:40 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 62,308
* Referee: Gene Steratore
* TV announcers (ESPN): Mike Tirico, Ron Jaworski, Jon Gruden, Suzy Kolber and Michele Tafoya
* Box Score
Game information :
First quarter
SF – Michael Crabtree 38-yard pass from Troy Smith (Shane Andrus kick), 9:35. 49ers 7–0. Drive: 1 play, 38 yards, 0:07.
ARI – Jay Feely 31-yard field goal, 5:56. 49ers 7–3. Drive: 7 plays, 55 yards, 3:39.
SF – Anthony Dixon 1-yard run (Shane Andrus kick), 0:29. 49ers 14–3. Drive: 10 plays, 55 yards, 5:27.
Second quarter
SF – Brian Westbrook 8-yard run (Shane Andrus kick), 7:23. 49ers 21–3. Drive: 6 plays, 42 yards, 2:44.
ARI – Jay Feely 39-yard field goal, 2:16. 49ers 21–6. Drive: 10 plays, 40 yards, 5:07.
Third quarter
SF – Shane Andrus 38-yard field goal, 2:38. 49ers 24–6. Drive: 7 plays, 44 yards, 3:53.
Fourth quarter
SF – Shane Andrus 26-yard field goal, 12:43. 49ers 27–6. Drive: 11 plays, 42 yards, 4:03.
Top passers
SF – Troy Smith – 11/23, 129 yards, TD, INT
ARI – Derek Anderson – 16/35, 196 yards, INT
Top rushers
SF – Brian Westbrook – 23 rushes, 136 yards, TD
ARI – Beanie Wells – 5 rushes, 13 yards
Top receivers
SF – Michael Crabtree – 2 receptions, 48 yards, TD
ARI – Early Doucet – 5 receptions, 60 yards :
Trying to snap a five-game losing streak, the Cardinals went home, donned their alternate uniforms again, and played a Week 12 NFC West duel with the San Francisco 49ers on Monday night. Arizona trailed early in the first quarter as 49ers quarterback Troy Smith completed a 38-yard touchdown pass to wide receiver Michael Crabtree. The Cardinals answered with a 31-yard field goal from kicker Jay Feely, but San Francisco struck back with running back Anthony Dixon getting a 1-yard touchdown run. The 49ers added onto their lead in the second quarter with running back Brian Westbrook getting an 8-yard touchdown run. Arizona would respond with Feely's 39-yard field goal. From there, San Francisco pulled away in the third quarter as 49ers kicker Shane Andrus made a 38-yard field goal, followed by his 26-yard field goal in the fourth quarter.
With the loss, the Cardinals fell to 3–8.

### Week 13: vs. St. Louis Rams

| Quarter | 1 | 2 | 3 | 4 | Total |
| Rams | 3 | 6 | 7 | 3 | 19 |
| Cardinals | 6 | 0 | 0 | 0 | 6 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: December 5
* Game time: 2:15 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 61,874
* Referee: Clete Blakeman
* TV announcers (Fox): Chris Myers and Kurt Warner
* Box Score
Game information :
First quarter
ARI – Jay Feely 45-yard field goal, 11:14. Cardinals 3–0. Drive: 8 plays, 44 yards, 3:46.
ARI – Jay Feely 41-yard field goal, 5:26. Cardinals 6–0. Drive: 9 plays, 65 yards, 4:40.
STL – Josh Brown 28-yard field goal, 0:24. Cardinals 6–3. Drive: 10 plays, 59 yards, 5:02.
Second quarter
STL – Josh Brown 52-yard field goal, 10:23. Tied 6–6. Drive: 7 plays, 15 yards, 3:30.
STL – Josh Brown 20-yard field goal, 0:04. Rams 9–6. Drive: 12 plays, 65 yards, 3:11.
Third quarter
STL – Steven Jackson 27-yard run (Josh Brown kick), 7:40. Rams 16–6. Drive: 10 plays, 85 yards, 4:42.
Fourth quarter
STL – Josh Brown 43-yard field goal, 14:55. Rams 19–6. Drive: 7 plays, 16 yards, 3:09.
Top passers
STL – Sam Bradford – 18/29, 187 yards, INT
ARI – Derek Anderson – 7/20, 93 yards, INT
Top rushers
STL – Steven Jackson – 28 rushes, 102 yards, TD
ARI – Tim Hightower – 15 rushes, 81 yards
Top receivers
STL – Brandon Gibson – 6 receptions, 54 yards
ARI – Steve Breaston – 3 receptions, 62 yards :
Hoping to break a six-game losing streak the Cardinals played on home ground for a division rivalry match against the Rams. The Cardinals took the early lead as kicker Jay Feely got a 45 and a 41-yard field goal. They soon trailed after kicker Josh Brown hit a 28, 52 and 20-yard field goal. This was followed in the third quarter by RB Steven Jackson getting a 27-yard TD run, and with Brown making a 43-yard field goal.
With the loss, the Cardinals fell to 3–9.

### Week 14: vs. Denver Broncos

| Quarter | 1 | 2 | 3 | 4 | Total |
| Broncos | 3 | 0 | 0 | 10 | 13 |
| Cardinals | 3 | 13 | 3 | 24 | 43 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: December 12
* Game time: 2:15 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 62,223
* Referee: Jerome Boger
* TV announcers (CBS): Bill Macatee and Rich Gannon
* Box Score
Game information :
First quarter
DEN – Stephen Hauschka 32-yard field goal, 10:36. Broncos 3–0. Drive: 11 plays, 73 yards, 4:24.
ARI – Jay Feely 36-yard field goal, 4:35. Tied 3–3. Drive: 4 plays, 5 yards, 0:58.
Second quarter
ARI – Jay Feely 48-yard field goal, 11:50. Cardinals 6–3. Drive: 7 plays, 17 yards, 2:58.
ARI – Jay Feely 5-yard run (Jay Feely kick), 4:02. Cardinals 13–3. Drive: 5 plays, 24 yards, 2:01.
ARI – Jay Feely 55-yard field goal, 0:02. Cardinals 16–3. Drive: 8 plays, 37 yards, 1:42.
Third quarter
ARI – Jay Feely 23-yard field goal, 9:40. Cardinals 19–3.Drive: 10 plays, 72 yards, 5:20.
Fourth quarter
ARI – Jay Feely 49-yard field goal, 14:55. Cardinals 22–3. Drive: 4 plays, 8 yards, 1:04.
DEN – Stephen Hauschka 30-yard field goal, 11:20. Cardinals 22–6. Drive: 7 plays, 13 yards, 2:16.
ARI – Tim Hightower 8-yard run (Jay Feely kick), 6:07. Cardinals 29–6. Drive: 8 plays, 79 yards, 5:13.
DEN – Knowshon Moreno 1-yard run (Stephen Hauschka kick), 3:31. Cardinals 29–13. Drive: 7 plays, 71 yards, 2:36.
ARI – Tim Hightower 35-yard run (Jay Feely kick), 3:09. Cardinals 36–13. Drive: 3 plays, 41 yards, 0:22.
ARI – Darnell Dockett 40-yard fumble return (Jay Feely kick), 2:42. Cardinals 43–13.
Top passers
DEN – Kyle Orton – 19/41, 166 yards, 3 INT
ARI – John Skelton – 15/37, 146 yards
Top rushers
DEN – Knowshon Moreno – 19 rushes, 81 yards, TD
ARI – Tim Hightower – 18 rushes, 148 yards, 2 TD
Top receivers
DEN – Jabar Gaffney – 3 receptions, 48 yards
ARI – Larry Fitzgerald – 6 receptions, 72 yards :
The Cardinals thirteenth game was an interconference duel with the Broncos. The Cardinals trailed early as Broncos kicker Steven Hauschka nailed a 32-yard field goal, but rallied to take the lead with kicker Jay Feely making a 36 and a 48-yard field goal, followed by his 5-yard TD run to the endzone, then he made a 55, 23 and a 49-yard field goal to put the Cardinals up 22–3. The lead was narrowed slightly as Hauschka got a 30-yard field goal, but the Cardinals increased their lead with RB Tim Hightower getting an 8-yard TD run. The Broncos tried to break down the lead as RB Knowshon Moreno got a 1-yard TD run, but the Cardinals pulled away with Hightower getting a 35-yard TD run, followed by DE Darnell Dockett recovering a fumble in the endzone for a touchdown.
With the win, Arizona improved to 4–9, and got their first-ever win over the Broncos in the franchise's history, though they tied in 1973 and never played the Broncos between 1978 and 1988. Despite losing nine games on the year, the Cardinals were still playoff-eligible in the very weak NFC West.

### Week 15: at Carolina Panthers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 0 | 3 | 0 | 9 | 12 |
| Panthers | 6 | 7 | 6 | 0 | 19 |
at Bank of America Stadium, Charlotte, North Carolina
* Date: December 19
* Game time: 1:00 p.m. EST/11:00 a.m. MST
* Game weather: Sunny, 42 °F (6 °C)
* Game attendance: 71,849
* Referee: Tony Corrente
* TV announcers (Fox): Ron Pitts, John Lynch and Nischelle Turner
* Box Score
Game information :
First quarter
CAR – John Kasay 28-yard field goal, 10:22. Panthers 3–0. Drive: 6 plays, 57 yards, 2:27.
CAR – John Kasay 29-yard field goal, 0:14. Panthers 6–0. Drive: 14 plays, 80 yards, 6:42.
Second quarter
CAR – Jeff King 16-yard pass from Jimmy Clausen (John Kasay kick), 8:42. Panthers 13–0. Drive: 1 play, 16 yards, 0:07.
ARI – Jay Feely 23-yard field goal, 0:36. Panthers 13–3. Drive: 12 plays, 46 yards, 4:19.
Third quarter
CAR – John Kasay 24-yard field goal, 12:12. Panthers 16–3. Drive: 6 plays, 31 yards, 2:48.
CAR – John Kasay 43-yard field goal, 0:27. Panthers 19–3. Drive: 10 plays, 21 yards, 6:29.
Fourth quarter
ARI – Steve Breaston 10-yard fumble return (run failed), 5:41. Panthers 19–9.
ARI – Jay Feely 30-yard field goal, 0:54. Panthers 19–12. Drive: 6 plays, 60 yards, 0:55.
Top passers
ARI – John Skelton – 17/33, 196 yards, INT
CAR – Jimmy Clausen – 13/19, 141 yards, TD
Top rushers
ARI – Tim Hightower – 6 rushes, 16 yards
CAR – Jonathan Stewart – 27 rushes, 137 yards
Top receivers
ARI – Larry Fitzgerald – 9 receptions, 125 yards
CAR – Brandon LaFell – 3 receptions, 33 yards :
Coming off their win over the Broncos the Cardinals flew to Bank of America Stadium for an NFC duel with the Panthers. In the first quarter the Cardinals trailed early as kicker John Kasay hit a 28 and a 29-yard field goal. This was followed in the second quarter by QB Jimmy Clausen completing a 16-yard touchdown pass to TE Jeff King. The Cardinals answered with kicker Jay Feely nailing a 23-yard field goal, but struggled further after Kasay made a 24 and a 43-yard field goal. The Cardinals tried to come back with Steve Breaston recovering a fumble in the end zone for a touchdown (With a failed two-point conversion) and then with Feely getting a 30-yard field goal, but the Panthers' defense was enough to secure themselves the win.
With the loss, Arizona fell to 4–10, and was officially ousted from the postseason for the first time since 2007.

### Week 16: vs. Dallas Cowboys

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cowboys | 0 | 10 | 10 | 6 | 26 |
| Cardinals | 14 | 7 | 0 | 6 | 27 |
at University of Phoenix Stadium, Glendale, Arizona
* Date: December 25
* Game time: 5:30 p.m. MST
* Game weather: None (retractable roof closed)
* Game attendance: 66,971
* Referee: Jeff Triplette
* TV announcers (NFL Network): Bob Papa, Matt Millen and Joe Theismann
* Box Score
Game information :
First quarter
ARI – Dominique Rodgers-Cromartie 32-yard interception return (Jay Feely kick), 12:47. Cardinals 7–0.
ARI – Greg Toler 66-yard interception return (Jay Feely kick), 8:24. Cardinals 14–0.
Second quarter
DAL – David Buehler 42-yard field goal, 12:49. Cardinals 14–3. Drive: 10 plays, 37 yards, 4:56.
ARI – Andre Roberts 74-yard pass from John Skelton (Jay Feely kick), 11:57. Cardinals 21–3. Drive: 2 plays, 80 yards, 0:52.
DAL – Jason Witten 2-yard pass from Jon Kitna (David Buehler kick), 5:11. Cardinals 21–10. Drive: 13 plays, 81 yards, 6:46.
Third quarter
DAL – David Buehler 53-yard field goal, 6:46. Cardinals 21–13. Drive: 5 plays, 26 yards, 1:59.
DAL – Marion Barber III 24-yard run (David Buehler kick), 1:58. Cardinals 21–20. Drive: 6 plays, 47 yards, 3:42.
Fourth quarter
ARI – Jay Feely 49-yard field goal, 3:45. Cardinals 24–20. Drive: 9 plays, 49 yards, 5:05.
DAL – Miles Austin 37-yard pass from Stephen McGee (kick failed), 1:41. Cowboys 26–24. Drive: 8 plays, 80 yards, 2:04.
ARI – Jay Feely 48-yard field goal, 0:05. Cardinals 27–26. Drive: 9 plays, 46 yards, 1:36.
Top passers
DAL – Jon Kitna – 12/20, 115 yards, TD, 2 INT
ARI – John Skelton – 11/25, 183 yards, TD
Top rushers
DAL – Felix Jones – 16 rushes, 77 yards
ARI – Beanie Wells – 11 rushes, 47 yards
Top receivers
DAL – Miles Austin – 6 receptions, 115 yards, TD
ARI – Andre Roberts – 5 receptions, 110 yards, TD :
This game marked the second time the Cardinals hosted the Cowboys on Christmas Day, after a 1995 Monday Night Football contest.

### Week 17: at San Francisco 49ers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Cardinals | 0 | 7 | 0 | 0 | 7 |
| 49ers | 7 | 3 | 21 | 7 | 38 |
at Candlestick Park, San Francisco, California
* Date: January 2
* Game time: 1:15 p.m. PST/2:150 p.m. MST
* Game weather: Rain, 49 °F (9 °C)
* Game attendance: 69,732
* Referee: Mike Carey
* TV announcers (Fox): Chris Myers and Jim Mora
* Box Score
Game information :
First quarter
SF – Ted Ginn Jr. 37-yard pass from Alex Smith (Jeff Reed kick), 4:45. 49ers 7–0. Drive: 1 play, 37 yards, 0:07.
Second quarter
SF – Jeff Reed 39-yard field goal, 14:18. 49ers 10–0. Drive: 8 plays, 36 yards, 3:46.
ARI – Larry Fitzgerald 10-yard pass from John Skelton (Jay Feely kick), 7:30. 49ers 10–7. Drive: 7 plays, 37 yards, 2:45.
Third quarter
SF – Vernon Davis 59-yard pass from Alex Smith (Jeff Reed kick), 13:02. 49ers 17–7. Drive: 5 plays, 75 yards, 1:58.
SF – Brian Westbrook 6-yard run (Jeff Reed kick), 8:50. 49ers 24–7. Drive: 6 plays, 78 yards, 3:08.
SF – Brian Westbrook 6-yard run (Jeff Reed kick), 6:51. 49ers 31–7. Drive: 2 plays, 8 yards, 0:40.
Fourth quarter
SF – Tarell Brown 62-yard interception return (Jeff Reed kick), 4:01. 49ers 38–7.
Top passers
ARI – Richard Bartel – 16/28, 150 yards, INT
SF – Alex Smith – 15/29, 276 yards, 2 TD
Top rushers
ARI – Tim Hightower – 12 rushes, 30 yards
SF – Brian Westbrook – 13 rushes, 79 yards, 2 TD
Top receivers
ARI – Larry Fitzgerald – 11 receptions, 125 yards, TD
SF – Vernon Davis – 3 receptions, 96 yards, TD :
The Cardinals' final game was an NFC West rivalry rematch against the 49ers. The Cardinals trailed early as QB Alex Smith completed a 37-yard TD pass to WR Ted Ginn Jr., followed in the 2nd quarter by kicker Jeff Reed making a 39-yard field goal. The Cardinals narrowed the lead as QB John Skelton completed a 10-yard TD pass to WR Larry Fitzgerald, but fell further behind after Smith completed a 59-yard TD pass to TE Vernon Davis, followed by RB Brian Westbrook running 6 yards to the endzone for a touchdown twice in succession. Arizona's offense continued to have problems as Richard Bartel's pass was intercepted by CB Tarell Brown and returned 62 yards for a touchdown.
With the loss, the Cardinals finished with a 5–11 record.