OpenLLM-France/wikimedia huggingface dataset:
# Monomethyl auristatin E

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.
MMAE is actually desmethyl-auristatin E; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin E itself.

## Mechanism of action

Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.
    Structure of a MMAE-MAB-conjugate. The linker, consisting of the amino acids valine (Val) and citrulline (Cit), is cleaved by cathepsin inside tumour cells. The spacer (para-aminobenzylcarbamate) is marked green, the cathepsin-cleavable linker is blue, and the attachment group (consisting of maleimide and caproic acid) is brown. The whole radical inside the four boxes is called vedotin.

## Monoclonal antibodies/ADCs

MMAE has been tested with various monoclonal antibodies (usually forming an antibody-drug conjugate).
* targeting the protein CD30 which is found on malignant cells in anaplastic large cell lymphoma and Hodgkin's lymphoma:
** Brentuximab (cAC10), 3–5 units of MMAE per molecule
* targeting the glycoprotein GPNMB which is found in aggressive melanoma, glioma, breast cancer and other tumours:
** Glembatumumab (CR011, CDX-011), investigated for the treatment of breast cancer and melanoma
* targeting CD37:
** AGS67E, to treat lymphoid malignancy
* targeting tissue factor in recurrent or persistent cervical cancers that progress on or after first line chemotherapy regimens:
** tisotumab vedotin
Examples:
* Sofituzumab vedotin
* Polatuzumab vedotin (RG7596)
* Enfortumab vedotin
* Pinatuzumab vedotin
* Lifastuzumab vedotin
* Brentuximab vedotin
* Glembatumumab vedotin
* Tisotumab vedotin
* Indusatumab vedotin (MLN-0264) in phase II trials
# Apriona moratii

Apriona moratii is a species of beetle in the family Cerambycidae. It was described by Jiroux in 2011.
# Sapporo Gakuin University

Sapporo Gakuin University (札幌学院大学, Sapporo gakuin daigaku) is a private university in Ebetsu, Hokkaido, Japan. Its predecessor, a vocational school, was founded in 1946. It was chartered as a junior college in 1950. A four-year college (Sapporo College of Commerce, 札幌商科大学) opened in 1968; it adopted the name Sapporo Gakuin University in 1984. The junior college was closed in 1979.

## Faculties and departments
### Undergraduate

* Faculty of Commerce (hiring freeze in 2009)
** Department of Commerce
* Faculty of Business
** Department of Business
** Department of Accounting and Finance
* Faculty of Economics
** Department of Economics
* Faculty of Humanities
** Department of Human Science
** Department of English Language and Literature
** Department of Clinical Psychology
** Department of Child Development
* Faculty of Law
** Department of Law
* Faculty of Social Information
** Department of Social Information

### Graduate schools

* Graduate School of Law
* Graduate School of Clinical Psychology
* Graduate School of Regional Management
# Melleroy

Melleroy (French pronunciation:) is a commune in the Loiret department in north-central France.
# North Side, Anguilla

North Side is one of the fourteen Districts of Anguilla. Its population at the 2011 census was 1,980.

## Demographics

Historical population of North Side, Anguilla (Source: Statoids.com) :
| Year | 1994 | 2001 | 2011 |
| Population | 667 | 1,195 | 1,980 |
# Charles Batt

Charles Leo Batt OAM (31 December 1928 – 27 October 2007), Australian politician, was a Labor member of the Tasmanian House of Assembly from 1974 to 1976, then a member of the Legislative Council from 1979 to 1995.
Born and raised in Tasmania, Batt was first elected to the House of Assembly on 26 July 1974 representing the electorate of Wilmot (now Lyons), where he served on the Public Accounts Committee, but was defeated at the next election on 11 December 1976.
On 26 May 1979, he was elected to the Legislative Council, the Tasmanian upper house, representing the electorate of Derwent. From 1989 to 1992 he was the leader for the government in the Legislative Council, and he retired from politics on 27 May 1995.
He received the National Medal in 1978. He was awarded the Medal of the Order of Australia in the Australia Day honours in 2001, for community service through sports clubs, local government and the Tasmanian parliament, and received the Australian Centenary Medal in the same year.
He managed his family's sheep farming property in the Tasmanian Midlands, and died on 27 October 2007.
# Salogo Department

Salogo is a department or commune of Ganzourgou Province in central-eastern Burkina Faso. Its capital lies at the town of Salogo. According to the 2006 census, the department has a total population of 21,405.

## Towns and villages

* Salogo (3,368 inhabitants)
* Boilghin (1,101 inhabitants)
* Filiba (1,511 inhabitants)
* Foulgo (843 inhabitants)
* Gnégnéogo (1,864 inhabitants)
* Koumséogo (2,589 inhabitants)
* Nonghin (1,333 inhabitants)
* Sambtenga (903 inhabitants)
* Sankango (1,651 inhabitants)
* Tandaga (753 inhabitants)
* Tansablogo (800 inhabitants)
* Yamegtenga (1,410 inhabitants)
* Zamsé (1,258 inhabitants)
* Zoétgomdé (186 inhabitants)
* Zomnogo (2,111 inhabitants).
# Monomial conjecture

In commutative algebra, a field of mathematics, the monomial conjecture of Melvin Hochster says the following:
Let A be a Noetherian local ring of Krull dimension d and let x$_1$, ..., x$_d$ be a system of parameters for A (so that A/(x$_1$, ..., x$_d$) is an Artinian ring). Then for all positive integers t, we have
    $x_{1}^{t}\cdots x_{d}^{t}\not \in (x_{1}^{t+1},\dots ,x_{d}^{t+1}).\,$
The statement can relatively easily be shown in characteristic zero.
# Of This I'm Sure

Of This I'm Sure is a studio album from Jenny & Tyler. Residence Music released the album on October 16, 2015.

## Critical reception

Professional ratings :
| Review scores ||
| Source | Rating |
| CCM Magazine | |
Awarding the album four stars at CCM Magazine, Kevin Sparkman asserts, "With refreshing sounds, and sing-able melodies to boot...The couple's sleeve-ridden sincerity and attention to painstaking detail make this project especially enjoyable." Brian Palmer, reviewing the album from C-Ville, states, "Whether it's the driving, swelling orchestral title track or the gorgeous ambient folk-pop update of fan favorite 'Song for You,' Jenny & Tyler's latest stirs your soul with anthemic music, lyrics that wind their way through your heart and crushing harmonies."

## Track listing

All tracks are written by Jenny & Tyler except they were joined by Gabe Scott on No. 6 and Jillian Edwards on No. 11

## Chart performance

| Chart (2015) | Peak position |
| US Christian Albums (Billboard) | 40 |
| US Folk Albums (Billboard) | 25 |
| US Heatseekers Albums (Billboard) | 18 |
# Hollywood, Luzerne County, Pennsylvania

Hollywood was an unincorporated community and coal town which was ultimately incorporated into the boundaries of Hazleton, Pennsylvania, United States.

## Notable person

* Sarah Knauss (1880–1999), a supercentenarian who lived to be 119 years old. She died in Allentown.
# Sapporo International Communication Plaza Foundation

The Sapporo International Communication Plaza Foundation (公益財団法人札幌国際プラザ, Kōeki Zaidan Hōjin Sapporo Kokusai Puraza), or SICPF, is an organization that aims to promote international events and projects and facilitate cultural exchanges in order to revitalize the local economy. Its headquarters is located in Chūō-ku, Sapporo, Hokkaido, Japan.

## Basic Information

The SICPF was established in 1991 by the Hokkaido District Transport Bureau and government of Hokkaido under the "3C principle" — Communication, Convention, Citizen — in order to gain the support and participation of local people and institutions.

## Major Activities

* Promoting international exchange and cooperation in various fields.
* Promoting multiculturalism and cross cultural understandings in city planning.
* Fostering the development of human resources needed to successfully carry out international exchanges.
* Conveying to the world the attractiveness of Sapporo as an international city.
* Engaging in other efforts beyond those mentioned above, when considered necessary to attain the Plaza's objectives.
# Brachyscome basaltica

Brachyscome basaltica, commonly known as swamp daisy, is a perennial herb in the family Asteraceae and is endemic to Australia. It has mostly white daisy-like flowers and a yellow centre.

## Description

Brachyscome basaltica is a perennial herb with slender, tufted branches 30–60 cm (12–24 in) long. The leaves are borne either along the aerial stems in clusters at the base of the stems. The branches are smooth or with glandular hairs less than 0.1 mm (0.0039 in) long. The leaves lance, egg-shaped or narrower, sessile, 30–50 mm (1.2–2.0 in) long, 3–14 mm (0.12–0.55 in) wide, tapering at the base. They are more or less sharply pointed at the apex, margins smooth, sometimes with a wavy appearance. The cluster of 10-22 overlapping bracts 3.5–5 mm (0.14–0.20 in) in diameter, individual bracts 2.5–4 mm (0.098–0.157 in) long, 1.1–2 mm (0.043–0.079 in) wide. The bracts soft, dry edges and the outer surface smooth or with a few glandular hairs. The flowers consist of 24-42 white or mauve petals, each petal about 4–6 mm (0.16–0.24 in) long. The one-seeded dry fruit initially flattened becoming more or less swollen at maturity, 1.5–2 mm (0.059–0.079 in) long with small warty protuberances on the surface.

## Taxonomy

Brachyscome basaltica was first formally described by Ferdinand von Mueller in 1858 and the description was published in Fragmenta Phytographiae Australiae.

## Distribution and habitat

Swamp daisy grows in wetter location in New South Wales, Victoria and Queensland.
# Carriage Club, Colorado

Carriage Club is a neighborhood in the City of Lone Tree, Douglas County, Colorado, United States. A former census-designated place (CDP), the population was 1,002 at the United States Census 2000.

## Geography

Carriage Club is located at 39°31′55″N 104°54′04″W﻿ / ﻿39.532°N 104.901°W﻿ / 39.532; -104.901.
# Meia lua de frente

Meia lua (crescent) or Meia lua de frente (front crescent) is one of the few principal kicks in capoeira. The kicking leg moves in the form of an arc before returning to its original position.
Meia lua is considered one of the first capoeira kicks to learn. It is the foundation for others crescent kicks in capoeira, such as armada or meia-lua de costas (back crescent) or queixada, which is like the inverse of a meia lua de frente.
Front crescent (or outside crescent) kick is seen in various martial arts. Meia lua is widely used in African martial art engolo, the forerunner of capoeira.

## Name

The meia lua (crescent) gets its name from the semicircle motion the leg performs when the player executes it.

## Origin

Front crescent kick (okupayeka) is one of the basic kicks in engolo, an Angolan martial art considered the ancestor of capoeira. There are numerous variations of the crescent kick in engolo:
* front crescent kick (meia lua de frente)
** high front crescent
** medium front crescent
** jumping front crescent
* reversed front crescent (queixada)
* back crescent kick (armada)
In engolo, the kicking leg can be extended fully or partially bent (which is considered incorrect in capoeira).
According to Desch-Obi, some engolo kicks was likely developed by Bantu shamans in Angola. Among the Pende shamans, the most important movement was the front crescent kick, the same as in engolo. During the ritual, masked shaman kicked over sacred medicine to activate it and over the kneeling people to heal them.

## Technique

When doing crescent kick in capoeira, the kicking leg is straight and the hips are pushed forward. This kick uses the hips to generate force and to propel the leg forward. The technique is similar to extending the leg over a chair.
Meia lua usually aims to bring the foot of the kicking leg across the opponent's face. Depending on the opponent's position, this kick can be delivered to various regions of the body, often to the opponent's face height. The kick should be finished when it reaches a point directly in front of the kicker.
While it can be used as an attack itself, it is also used as a poke or trap for another attack. Meia lua is a good kick to feel out the opponent’s style. Because it is usually low and frontal it doesn’t open the player to sweeps or counterattacks.
Other uses for meia lua can be as a combination with cartwheels and other acrobatic moves, working as an escape.

## Defenses

Defense can be applied in various ways, usually by moving away and quickly lowering the body. From that position it is possible to deliver a rabo de arraia to the attacker by swiftly rotating the body, or even use chapa de costas.
The defender could also move away and, quickly descending, tried to take down the attacker with a sweep (rasteira).
# Alexander Monteith

Alexander Monteith may refer to:
* Alec Monteith (Alexander Lamont Monteith, 1886–1972), New Zealand politician
* Alexander C. Monteith (1902–1979), Canadian businessman
* Alexander Monteith (surgeon) (1660–1713), Edinburgh surgeon
# Nebuchadnezzar (governor of Uruk)

Nebuchadnezzar (Babylonian cuneiform: Nabû-kudurri-uṣur, meaning "Nabu, watch over my heir"), also spelled Nebuchadrezzar, and most commonly known under the nickname Kudurru, was a governor of the city Uruk in Babylonia under the rule of Ashurbanipal (r. 669–631 BC) of the Neo-Assyrian Empire, appointed after the defeat of Shamash-shum-ukin of Babylon, Ashurbanipal's brother who had rebelled against Assyria, c.  648 BC. He was likely the son of the high priest Nabonassar.
In the reign of Ashurbanipal's son Sinsharishkun (r. 627–612 BC), the grave of Nebuchadnezzar was desecrated, with the perpetrators going so far as dragging his body through the streets of Uruk. This was done as a response to the anti-Assyrian activities of his two sons. In 2007, Assyriologist Michael Jursa identified Nebuchadnezzar as the father of Nabopolassar, the founder of the Neo-Babylonian Empire, who rebelled against Sinsharishkun in 626 BC (this being the anti-Assyrian activities). If Nabopolassar was his son, Nabopolassar would go on to name his own son, Nebuchadnezzar II, after his father.
# William Maclay

William Maclay may refer to:
* William Maclay (Pennsylvania politician, born 1737) (1737–1804), United States Senator from Pennsylvania
* William Maclay (Pennsylvania politician, born 1765) (1765–1825), United States Representative from Pennsylvania
* William Plunkett Maclay (1774–1842), United States Representative from Pennsylvania, nephew of the senator
* William B. Maclay (1812–1882), United States Representative from New York
* William P. Maclay (Medal of Honor) (1877–1943), Philippine Insurrection Medal of Honor recipient
# Ofahiki Ogden

Ofahiki Ogden (born 6 June 1996) is a New Zealand rugby league footballer who last played as a prop for the Parramatta Eels in the National Rugby League (NRL). He previously played for the Canterbury-Bankstown Bulldogs.

## Early life

Ogden was born in Auckland, New Zealand. He is of Tongan descent. He played his junior rugby league for the Mangere East Hawks and attended De La Salle College, Mangere East.

## Playing career
### Canterbury-Bankstown Bulldogs (2018–2021)

Ogden made his NRL debut for Canterbury-Bankstown in round 16 of the 2018 NRL season against the Newcastle Knights.
Ogden spent most of the 2018 season playing with Canterbury's reserve grade team. Ogden played in the club's Intrust Super Premiership NSW grand final victory over Newtown at Leichhardt Oval. The following week, Ogden played in Canterbury's NRL State Championship side which defeated Redcliffe 42-18 at ANZ Stadium.
Ogden made 13 appearances for Canterbury in the 2019 NRL season as the club finished 12th on the table.
Ogden played 11 games for Canterbury in the 2020 NRL season. The club finished 15th on the table and only avoided the wooden spoon due to a better for and against over last placed Brisbane.
Ogden made a total of 12 appearances for Canterbury in the 2021 NRL season as the club finished last and claimed the Wooden Spoon.

### Parramatta Eels (2022–2024)

On 28 November 2021, Ogden signed a train and trial deal with Canterbury's arch rivals, the Parramatta Eels. On 20 February 2022, Ogden signed a three-year deal with Parramatta until the end of 2024. Ogden made his club debut for Parramatta in round 22 of the 2022 NRL season against South Sydney which ended in a 26-0 loss. Ogden played a total of nine matches for Parramatta in the 2023 NRL season as the club finished 10th and missed the finals. On 18 April 2024, it was announced that Ogden would miss at least 12 weeks with a pectoral tear following Parramatta's victory over North Sydney in the NSW Cup. On 11 September, it was announced that Ogden would be departing the Parramatta club after not being offered a new contract.

## Controversy

On 2 October 2021, Ogden was arrested by NSW Police for alleged drug possession. The matter was then referred onto the NRL Integrity Unit. On 11 November, Ogden pleaded guilty to cocaine possession but avoided conviction at Waverley Local Court.
# Hollywood, Monroe County, West Virginia

Hollywood is an unincorporated community in Monroe County, West Virginia, United States. Hollywood is northeast of Union.
The community was so named on account of holly bushes near the original town site.
# Catholic Church in Senegal

The Catholic Church in Senegal is part of the worldwide Catholic Church, under the spiritual leadership of the Pope in Rome.
In 2020, there were between 500,000 and 865,000 Catholics across 163 parishes in Senegal. The country is divided into seven dioceses including one archdiocese.
In 2021, there were 316 Catholic schools in Senegal.
# XX (novel)

XX is a 2020 science fiction novel by writer Rian Hughes.

## Design and publication

Hughes created a new typeface for the novel. Adapting the novel for e-readers was difficult, and Hughes considers the printed book to be the way the novel "should be read". Due to its use of graphic elements, artwork, a novel within the novel, asemic writing, and epistolary techniques, it can be considered a work of ergodic literature.

## Reception

According to literary review aggregator Book Marks, the novel received mostly "Rave" reviews.
Neville Hawcock, writing for The Financial Times, praised the graphic elements of the book as an "enjoyable variation" from typical novels. Lydia Fletcher, in a review published by The Library Journal, criticized the novel as occasionally "difficult to follow" in part due to the "mixed-media" portions.
# Sanhe Subdistrict, Sandu County

Sanhe Subdistrict (Chinese: 三合街道; pinyin: Sānhé Jiēdào) is a subdistrict in and the seat of Sandu Shui Autonomous County in southeastern Guizhou province, China. As of 2018, it has 5 residential communities (社区) and 5 villages under its administration.
# Meiacanthus bundoon

Meiacanthus bundoon, the Bundoon blenny, is a species of combtooth blenny from the Pacific Ocean where it is known from Fiji and Tonga. This species grows to a length of 8 centimetres (3.1 in) TL.
# Alfred Görnemann

Alfred Görnemann (1 September 1877 – 11 October 1903) was a German cyclist who had his best achievements in motor-paced racing. He started training in this discipline only in 1901, after completing his military service, but quickly became a top competitor. The same year he won a bronze medal at the UCI Motor-paced World Championships and became a champion next year in the amateurs division. In 1903 he turned professional and won another bronze medal.
On 11 October 1903 during a 100 km race in Dresden, while trying to overcome his rival Thaddäus Robl, he collided with his pacer, sustaining a spinal injury and skull fracture. He died the same evening and was buried on 15 October 1903 in Berlin.
# Wilhelm of the Palatinate-Zweibrücken

Philippe Guillaume aka Philipp Wilhelm Graf von Forbach, then Vicomte de Deux-Ponts and later Freiherr von Zweibrücken (1754–1807) was an officer of the French and later general of the Bavarian Army.

## Early life and ancestry

Wilhelm von Zweibrücken was the second of six children of Christian IV Herzog von Pfalz-Zweibrücken and Maria Johanna Camasse, Gräfin von Forbach (1734-1807). The children were unable to succeed to their father's Duchy due to the morganatic nature of their parents' marriage at first, but were allowed to wear the name Freiherr von Zweibrücken in 1792.

## Biography

Due to a former business agreement of Louis XV of France and his father from March 1751, who promised to the French king to raise a German battalion of infantry for France when and if needed, the Infantry Regiment "Royal Deux-Ponts" (raised on 19, 1757) of two battalions to the French crown after the outbreak of the Seven Years' War, when it was at first deployed in the Battle of Rossbach. The commander of the regiment at this time was his older brother Christian, and Wilhelm was deputy commander.
In 1780, he married Martine-Adelaide de Polastron (1760-1795). The couple had four children, named Christian (1782–1859, a later general), Karl (1784-1812), Maria Anna, Gräfin von Forbach (1785-1857) and Henriette.
As part of De Rochambeau's expedition corps the "Royal Deux-Ponts" during the American Revolutionary War, where the regiment served in the siege of Yorktown, also called the "German Battle", on October 4, 1781. Especially the assault of Redoubt 9 by 400 French regulars under his command, that opened the British defenses was mentioned. After the French Revolution, he served as a general in the Bavarian army, and died in Munich, where he and his brother Christian are buried in the Old Southern Cemetery.
In the European Rosegarden in Zweibrücken there is a memorial of him and his brother.

## Awards

* Order of Saint Louis

## References and notes

* ↑ Regarding personal names: Until 1919, Graf was a title, translated as Count, not a first or middle name. The female form is Gräfin. In Germany, it has formed part of family names since 1919.
* ↑ Regarding personal names: Freiherr is a former title (translated as 'Baron'). In Germany since 1919, it forms part of family names. The feminine forms are Freifrau and Freiin.
* ↑ also findable under von Zweybrücken
* 1 2 Colonel Christian von Forbach and Lt.Col. Wilhelm von Forbach
* ↑ Zweibrücken (German), Pierer's Universal-Lexikon.
* ↑ France and Great Britain on the Eve of American Independence - The officer corps.
* ↑ Viscount Philippe of Deux-Ponts, RootsWeb.
* ↑ Royal Deux-Ponts Infanterie durant la Guerre d'Indépendance (French).
* ↑ Mößlang: Gedenkplatte bei den Arkaden an der Außenmauer des Alten Südlichen Friedhofs. (German).
* ↑ Preliminary Survey of Sites Associated with the Lives and Deeds of Foreign-born Heroes of the American Revolution, p. 42.