# List of number-one Billboard Regional Mexican Songs of 2021

The Billboard Regional Mexican Songs is a subchart of the Latin Airplay chart that ranks the best-performing songs on Regional Mexican radio stations in the United States. Published weekly by Billboard magazine, it ranks the "most popular regional Mexican songs, ranked by radio airplay audience impressions as measured by Nielsen Music."

## Chart history

Key :
| † | Indicates best-performing song of 2021 |
| Issue date | Song | Artist(s) |
| January 2 | "Te Volveria A Elegir" † | Calibre 50 |
| January 9 | "Te Volveria A Elegir" † | Calibre 50 |
| January 16 | "Te Volveria A Elegir" † | Calibre 50 |
| January 23 | "Te Volveria A Elegir" † | Calibre 50 |
| January 30 | "Dime Cómo Quieres" | Christian Nodal & Ángela Aguilar |
| February 6 | "Dime Cómo Quieres" | Christian Nodal & Ángela Aguilar |
| February 13 | "Dime Cómo Quieres" | Christian Nodal & Ángela Aguilar |
| February 20 | "Dime Cómo Quieres" | Christian Nodal & Ángela Aguilar |
| February 27 | "Dime Cómo Quieres" | Christian Nodal & Ángela Aguilar |
| March 6 | "Saludos A Mi Ex" | Edwin Luna and La Trakalosa de Monterrey |
| March 13 | "Yo Todo Lo Doy" | Alfredo Olivas |
| March 20 | "Saludos A Mi Ex" | Edwin Luna and La Trakalosa de Monterrey |
| March 27 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga |
| April 3 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga |
| April 10 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga |
| April 17 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga |
| April 24 | "Duele" | Alejandro Fernández and Christian Nodal |
| May 1 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga |
| May 8 | "Vamos Bien" | Calibre 50 |
| May 15 | "La Casita" | Banda Sinaloense MS de Sergio Lizarraga |
| May 22 | "2 Veces" | Los Plebes del Rancho de Ariel Camacho and Christian Nodal |
| May 29 | "2 Veces" | Los Plebes del Rancho de Ariel Camacho and Christian Nodal |
| June 5 | "2 Veces" | Los Plebes del Rancho de Ariel Camacho and Christian Nodal |
| June 12 | "2 Veces" | Los Plebes del Rancho de Ariel Camacho and Christian Nodal |
| June 19 | "Mi Primer Derrota" | La Arrolladora Banda el Limon de Rene Camacho |
| June 26 | "Te Encontré" | Ulices Chaidez / Eslabon Armado |
| July 3 | "Calzones Finos" | Los Nuevos Federales |
| July 10 | "Ya Te La Sabes" | Julión Álvarez y Su Norteno Banda |
| July 17 | "Sin Miedo Al Exito" | Banda Los Sebastianes de Saul Plata |
| July 24 | "Ya Te La Sabes" | Julión Álvarez y Su Norteno Banda |
| July 31 | "Ya Te La Sabes" | Julión Álvarez y Su Norteno Banda |
| August 7 | "Ya Te La Sabes" | Julión Álvarez y Su Norteno Banda |
| August 14 | "Soy Buen Amigo" | El Fantasma |
| August 21 | "A La Antiguita" | Calibre 50 |
| August 28 | "A La Antiguita" | Calibre 50 |
| September 4 | "A La Antiguita" | Calibre 50 |
| September 11 | "El Toxico" | Grupo Firme and Carin Leon |
| September 18 | "El Toxico" | Grupo Firme and Carin Leon |
| September 25 | "Tus Desprecios" | Pepe Aguilar and El Fantasma |
| October 2 | "Se Veia Venir" | Marco Antonio Solís |
| October 9 | "Que Tienen Tus Palabras?" | Banda El Recodo de Cruz Lizarraga |
| October 16 | "Tranquilito" | Gerardo Ortiz |
| October 23 | "Tranquilito" | Gerardo Ortiz |
| October 30 | "Ya Supérame (En Vivo Desde Culiacán, Sinaloa)" | Grupo Firme |
| November 6 | "Ya Supérame (En Vivo Desde Culiacán, Sinaloa)" | Grupo Firme |
| November 13 | "Ya Supérame (En Vivo Desde Culiacán, Sinaloa)" | Grupo Firme |
| November 20 | "Yo Soy Rico" | Los Dos Carnales |
| November 27 | "La Sinvergüenza" | Christian Nodal and Banda MS |
| December 4 | "La Sinvergüenza" | Christian Nodal and Banda MS |
| December 11 | "Como Te Olvido" | La Arrolladora Banda el Limon de Rene Camacho |
| December 18 | "Como Te Olvido" | La Arrolladora Banda el Limon de Rene Camacho |
| December 25 | "Ya Solo Eres Mi Ex" | La Adictiva |