OpenLLM-France/wikimedia huggingface dataset:
# Norepinephrine releasing agent

A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into the synapse. This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine therefore an increase in adrenergic neurotransmission.
A closely related type of drug is a norepinephrine reuptake inhibitor (NRI), for instance reboxetine. Another class of drugs that stimulates adrenergic activity is the adrenergic receptor agonist class.

## Uses and examples

NRAs, frequently as norepinephrine–dopamine releasing agents (NDRAs) rather than as selective NRAs, are used for a variety of clinical indications including the following:
* For the treatment of attention deficit hyperactivity disorder (ADHD) — e.g., amphetamine, dextroamphetamine, levoamphetamine, lisdexamfetamine, methamphetamine
* As anorectics in the treatment of obesity and binge-eating disorder — e.g., amphetamine, lisdexamfetamine, phentermine, benzphetamine, phenmetrazine, aminorex
* As wakefulness-promoting agents in the treatment of narcolepsy — e.g., amphetamine, methamphetamine
* As nasal decongestants and bronchodilators — e.g., levomethamphetamine, propylhexedrine, ephedrine, pseudoephedrine, phenylpropanolamine
* Miscellaneous – e.g., amantadine
They are also used as recreational drugs, though this is typically reserved only for those that also induce the release of dopamine and/or serotonin, for instance amphetamine, methamphetamine, MDMA, mephedrone, 4-methylaminorex, and MDAI, among others.
Cathine and cathinone are NRAs found naturally in Catha edulis. Ephedrine and pseudoephedrine are also found naturally in Ephedra sinica. Both of these plants are used medicinally (and recreationally as well regarding the former). The endogenous trace amines phenethylamine and tyramine are NRAs found in many animals, including humans.
Selective NRAs include ephedrine, pseudoephedrine, phenylpropanolamine, levomethamphetamine, and D-phenylalaninol. These drugs also release dopamine to a much lesser extent however (e.g., ~10- to 20-fold less potently). No highly selective NRAs are currently known. Among the most selective known NRAs is ephedrine, which had about 19-fold higher potency for inducing norepinephrine release over dopamine release in one study. Levomethamphetamine has shown about 15-fold higher potency in inducing norepinephrine release over dopamine release. D-Phenylalaninol has 13-fold higher potency in inducing norepinephrine release over dopamine release. In contrast to levomethamphetamine, levoamphetamine is an NDRA, with only about 3-fold preference for inducing norepinephrine release over dopamine release in one study (versus dextroamphetamine being roughly equipotent on norepinephrine and dopamine release in the same study). NRAs play a significant role in treating ADHD, obesity, narcolepsy, and as sympathomimetics by enhancing adrenergic signaling.
# Andy Mulligan (author)

Andy Mulligan is a British writer best known for young adult fiction. Raised in South London, he worked as a theatre director for ten years before retraining as a teacher. His teaching career took him to India, Brazil, Vietnam, the Philippines, and the UK, experiences that have strongly influenced his writing. He has been married to Anne Robinson since their elopement in 2015. He now divides his time between London and Manila.

## Career

Mulligan's first novel, Ribblestrop, was published by Simon & Schuster in 2009. The story originated "on a walk with a fellow teacher"; they talked about they might turn a particular "ramshackle stately home ... into a thoroughly inappropriate school".
His second novel, Trash, is set in the garbage dump of a large unnamed third world city reminiscent of Manila, and features a street child who lives as a waste picker. It was shortlisted for one of the annual Blue Peter Book Awards, but dropped "because it contains scenes of violence and swearing that are not suitable for the younger end of" the Blue Peter audience. David Fickling, the publisher of Trash, stated that "poor children live a very unpleasant life and to avoid that would be untruthful, and I don't think one should be untruthful to children. You can't make life wonderfully safe and middle-class all over the world." Trash was later shortlisted for the 2012 CILIP Carnegie Medal. A film adaptation of Trash directed by Stephen Daldry was released in 2014.
Return to Ribblestrop (2011) was the first of two Ribblestrop sequels. Mulligan won the 2011 Guardian Children's Fiction Prize, a once-in-a-lifetime book award judged by a panel of British children's writers. "It is so fresh: the judges loved its anarchy, its good humour, its warm heart and the way it depicted children," according to committee chair Julia Eccleshare, children's book editor

## Works

* Ribblestrop (Simon & Schuster Children's Books, 2009)
* Trash (David Fickling Books, 2010)
* Return to Ribblestrop (Simon & Schuster, 2011)
* Ribblestrop Forever! (Simon & Schuster, 2012)
* The Boy With Two Heads (RHCP Digital, 2013)
* Liquidator (David Fickling Books, 2015)
* Rollercoaster:(Adventure Book Box, 2016)
* Dog (Pushkin Children's Books, 2017

## Awards

* 2011 Guardian Children's Fiction Prize for Return to Ribblestrop
* Ribblestrop was shortlisted for a Roald Dahl Funny Prize in 2009.
* Trash was shortlisted for the CILIP Carnegie Medal in 2012.
# John Walcot

John Walcot (1697–1765), of Walcot, Shropshire, was a British Tory politician who sat in the House of Commons from 1727 to 1734.
Walcot was baptized on 24 June 1697, the eldest son of Charles Walcot of Walcot and his second wife Anne Brydges, daughter of James Brydges, 8th Baron Chandos of Sudeley. He matriculated at Magdalen College, Oxford on 16 July 1715, aged 16, and was created MA on 6 March 1720. In 1726 he succeeded to his father's estate at Walcot. He married Mary Dashwood, daughter. of Sir Francis Dashwood, 1st Baronet MP of West Wycombe, Buckinghamshire, on 15 May 1732.
In 1727 Walcot purchased the manor of Bishop's Castle from his uncle, the Duke of Chandos, for £7,000, and so acquired the chief electoral interest there. He had an income of £3,000 a year, but was burdened with a debt of £22,000 and was advised by his uncle not to stand for Shropshire until he had paid off the debt.
Ignoring Chandos's advice, Walcot was returned as a Tory Member of Parliament for Shropshire at the 1727 British general election. He voted against the government. Although he did not stand again at the 1734 British general election, he continued to support his interest at Bishop's Castle, which put him further into debt. By 1742 he owed over £33,000 and had to obtain a private act of Parliament, Walcot's Estate Act 1741 (15 Geo. 2. c. 31 Pr.), to raise money on his wife's portion. Before the 1747 British general election he borrowed £8,500 from his banker, Samuel Child, who was standing for Bishop's Castle. By 1761, his debts had risen to over £48,000. He was forced to hide from his creditors, leaving his son and lawyer to sell his property Walcot Hall to Lord Clive for £92,000.
Walcot died in 1765 leaving two sons.
# Sankt Oswald bei Plankenwarth

Sankt Oswald bei Plankenwarth is a municipality in the district of Graz-Umgebung in the Austrian state of Styria. It has a population of around 1,300 residents. Key landmarks of this region are the Pfarrkirche St. Oswald, a Roman Catholic parish church perched on a hill, and the Schloss Plankenwarth.
# 2021 in Sierra Leone

Events in the year 2021 in Sierra Leone.

## Incumbents

* President of Sierra Leone Julius Maada Bio

## Events

* Freetown fuel tanker explosion
* COVID-19 pandemic in Sierra Leone
# Tom Riley (footballer)

Thomas Riley (27 November 1881 – November 1942) was an English professional footballer who played as a full back in the Football League for Blackburn Rovers and Aston Villa.

## Career statistics

Appearances and goals by club, season and competition :
| Club | Season | League | League | League | FA Cup | FA Cup | Total | Total |
| Club | Season | Division | Apps | Goals | Apps | Goals | Apps | Goals |
| Blackburn Rovers | 1902–03 | First Division | 5 | 0 | 0 | 0 | 5 | 0 |
| Blackburn Rovers | 1903–04 | First Division | 16 | 0 | 0 | 0 | 16 | 0 |
| Blackburn Rovers | 1904–05 | First Division | 1 | 0 | 0 | 0 | 1 | 0 |
| Blackburn Rovers | Total | Total | 22 | 0 | 0 | 0 | 22 | 0 |
| Brentford | 1905–06 | Southern League First Division | 29 | 0 | 4 | 0 | 33 | 0 |
| Aston Villa | 1905–06 | First Division | 4 | 0 | — | — | 4 | 0 |
| Aston Villa | 1906–07 | First Division | 5 | 0 | 0 | 0 | 5 | 0 |
| Aston Villa | 1907–08 | First Division | 7 | 0 | 0 | 0 | 7 | 0 |
| Aston Villa | Total | Total | 16 | 0 | 0 | 0 | 16 | 0 |
| Career total | Career total | Career total | 67 | 0 | 4 | 0 | 71 | 0 |
# Darevskia lindholmi

Darevskia lindholmi is a lizard species in the genus Darevskia. It is endemic to Ukraine.
# Church of St Michael the Archangel, Shalfleet

50°42′04″N 01°24′55″W﻿ / ﻿50.70111°N 1.41528°W﻿ / 50.70111; -1.41528
The Church of St. Michael the Archangel, Shalfleet is a parish church in the Church of England located in Shalfleet, Isle of Wight.

## History

The church is medieval.
The dedication to St. Michael was made in 1964 as the previous dedication had been lost.
It has a tower that was built in 1070. It originally had no ground level door, and the entrance was through a door on the roof. Parishioners had to access the room by climbing a ladder. The walls of the church are five feet thick and it was a refuge for residents during attacks by the French who had sailed up Newtown Creek. A "3 pound" parish gun which was inscribed 'Schawflet' was kept in the tower until 1779.
The church had a steeple that was added around 1800, but the steeple was determined to be unstable and it was removed in 1912. The money for the steeple was raised by selling the parish gun and the church bells. This resulted in a local rhyme:
       "Shalfleet poor and simple people
       Sold their bells to build a steeple."
In 1889 the plaster was removed from ceiling and walls—the latter a questionable proceeding—the tower arch unblocked, a new door cut through the north face and the east window of the aisle reconstructed.
The church is fortunate in having escaped late additions and thus remaining an excellent example, with the exception of the tower, of late 13th-century work. The entry is by the north door, bearing the date 1754 on its inner face, through the 12th-century opening with its primitive carved tympanum. The north wall is practically modern work, partly rebuilt on the old foundation and of the same thickness in 1812, when wooden mullioned windows with brick reveals took the place of what may have been 15th-century lights. The insertion of the wide arch in the 13th century, practically cutting away the whole eastern face of the tower at this stage, has resulted in a serious subsidence to the north and east, with a corresponding contortion of the arch. When this was blocked as a precautionary measure there is nothing to show, but its opening in 1889 and the cutting of a door in the northern face of the tower was an unwise and risky proceeding, probably resulting in the serious crack in the upper part of the north-east angle.
A noticeable feature in the church is that the floor slopes down gradually to the east end without a break at the chancel arch.
The two bells in the tower are inscribed 'May all whom I shall summon to the grave, The ransom of a well-spent life receive. Thos. Way, James Street, Churchwardens, 1815. T. Mears of London fecit.' The smaller bell has only the names of the churchwardens, J. Jolliffe and J. Cooper, and the date 1807.
The churchyard contains the Commonwealth war grave of a World War II officer of the Queen's (Royal West Surrey) Regiment.
# Mátyás Usztics

Mátyás Usztics (9 April 1949 – 29 April 2017) was a Hungarian stage and film actor, most notable for his role of Sgt. János Karádi in the Hungarian television show Angyalbőrben. As a regular voice actor too, he was the Hungarian dubbing voice of Roger Rabbit in Who Framed Roger Rabbit and Gopher in The Many Adventures of Winnie the Pooh. He served as founding director of the National Chamber Theatre from 2003 until his death.
Usztics was a founding member and "commander" of the Magyar Gárda, de facto paramilitary wing of the nationalist Jobbik party. He resigned from his position after three months.

## Selected filmography

* Csutak és a szürke ló (1961)
* Magyar rapszódia (1979)
* Allegro barbaro (1979)
* Angi Vera (1979)
* Rosszemberek (1979) - Vekóczi
* Kinek a törvénye? (1979) - Csatkai
* Vasárnapi szülök (1980) - Juli sógora
* Fábián Bálint találkozása Istennel (1980) - Balla Károly unokája
* Circus maximus (1980) - Öcsi
* A mérközés (1981)
* A zsarnok szíve, avagy Boccaccio Magyarországon (1981)
* Requiem (1982) - Szabadult fogoly
* Cha-Cha-Cha (1983) - Sztásni
* The Train Killer [hu] (1983) - Gömöri
* Délibábok országa (1983)
* Könnyü testi sértés (1983)
* Tight Quarters (1983) - Swede
* Az óriás (1984)
* Uramisten (1984)
* Házasság szabadnappal (1984) - Csaba
* Flowers of Reverie (1985) - Rendõrparancsnok
* Mata Hari (1985) - Stable N.C.O.
* Dráma a vadászaton (1986)
* Az erdö kapitánya (1988) - Sanislo (voice)
* Willy the Sparrow (1989) - Spagyi, a fõveréb (voice)
* Angyalbőrben (1990–1991, TV Series) - Karádi õrmester
* Stalin (1992, TV Movie) - Yezhov
* Kutyabaj (1992)
* Kisváros (1993–1999, TV Series) - Hunyadi János fõtörzs
* Macskafogó 2 - A sátán macskája (2007) - Mióka (voice)
* The Tragedy of Man (2011) - Lucifer (voice) (final film role)
# AS-105

AS-105 was the fifth and final orbital flight of a boilerplate Apollo spacecraft, and the third and final launch of a Pegasus micrometeoroid detection satellite. It was launched by SA-10, the tenth and final Saturn I rocket, in 1965.

## Overview

AS-105 was an Apollo boilerplate spacecraft; boilerplate BP-9A was used for the flight. The spacecraft reentered on November 22, 1975. The Saturn launch vehicle (SA-10) was similar to those of missions AS-103 and AS-104. As on the previous mission, the boilerplate service module was equipped with a test installation of a reaction control engine package.
The primary flight objective was to continue demonstration of the launch vehicle's iterative guidance mode and evaluation of system accuracy.

## Launch

AS-105 was launched from Cape Kennedy Launch Complex 37B at 08:00 EST (13:00 GMT) on July 30, 1965, on the last Saturn I rocket, SA-10. A planned thirty-minute hold ensured that launch time coincided with the opening of the Pegasus launch window. The launch was normal and the payload was inserted into orbit approximately 10.7 minutes after lift-off. The total mass placed in orbit, including the spacecraft, Pegasus spacecraft, adapter, instrument unit, and S-IV stage, was 34,438 pounds (15,621 kg).
The spacecraft was separated 812 seconds after lift-off and the separation and ejection system operated as planned. The Pegasus 3 spacecraft, which was attached to the S-IV stage of the Saturn I and stowed inside the boilerplate service module, was deployed 40 seconds after command initiation at 872 seconds. Pegasus 3 was a 1423.6 kilogram (3138.6 pound) micrometeoroid detection satellite, which was bolted to the S-IV.
# Japanese submarine Yu 4

Yu 4 was an Imperial Japanese Army transport submarine of the Yu 1 subclass of the Yu I type. Constructed for use during the latter stages of World War II, she served in the waters of the Japanese archipelago.

## Construction

In the final two years of World War II, the Imperial Japanese Army constructed transport submarines — officially the Type 3 submergence transport vehicle and known to the Japanese Army as the Maru Yu — with which to supply its isolated island garrisons in the Pacific Ocean. Only submarines of the Yu I type were completed and saw service. The Yu I type was produced in four subclasses, each produced by a different manufacturer and differing primarily in the design of their conning towers and details of their gun armament. None carried torpedoes or had torpedo tubes. Yu 4 was a unit of the Yu 1 subclass.
The Hitachi Kasado Works (Hitachi Kasado Seisakujo) at Kudamatsu, Japan, constructed Yu 4. Records of the details of the construction of Yu 4 have not been discovered, but the earlier Yu I-type submarines were laid down and launched during the latter half of 1943 and entered service at the end of 1943 or early in 1944.

## Service history

Yu 4 spent her operational career in Japanese home waters. Surviving records of the activities of Imperial Japanese Army submarines are fragmentary, and no records have been discovered describing her specific activities in support of any particular operation.
World War II ended with the cessation of hostilities on 15 August 1945.Yu 4 surrendered to the Allies later in August 1945. She subsequently either was scuttled or scrapped.
# Japanese submarine Yu 5

Yu 5 was an Imperial Japanese Army transport submarine of the Yu 1 subclass of the Yu I type. Constructed for use during the latter stages of World War II, she served in the waters of the Japanese archipelago.

## Construction

In the final two years of World War II, the Imperial Japanese Army constructed transport submarines — officially the Type 3 submergence transport vehicle and known to the Japanese Army as the Maru Yu — with which to supply its isolated island garrisons in the Pacific Ocean. Only submarines of the Yu I type were completed and saw service. The Yu I type was produced in four subclasses, each produced by a different manufacturer and differing primarily in the design of their conning towers and details of their gun armament. None carried torpedoes or had torpedo tubes. Yu 5 was a unit of the Yu 1 subclass.
The Hitachi Kasado Works (Hitachi Kasado Seisakujo) at Kudamatsu, Japan, constructed Yu 5. Records of the details of the construction of Yu 5 have not been discovered, but the earlier Yu I-type submarines were laid down and launched during the latter half of 1943 and entered service at the end of 1943 or early in 1944.

## Service history

Yu 5 spent her operational career in Japanese home waters. Surviving records of the activities of Imperial Japanese Army submarines are fragmentary, and no records have been discovered describing her specific activities in support of any particular operation.
World War II ended with the cessation of hostilities on 15 August 1945.Yu 5 surrendered to the Allies later in August 1945. She subsequently either was scuttled or scrapped.
# Wybudowanie Wielbrandowskie

Wybudowanie Wielbrandowskie is a village in the administrative district of Gmina Skórcz, within Starogard County, Pomeranian Voivodeship, in northern Poland. It lies approximately 2 kilometres (1 mi) north-east of Skórcz, 18 km (11 mi) south of Starogard Gdański, and 62 km (39 mi) south of the regional capital Gdańsk.
For details of the history of the region, see History of Pomerania.
# Jarallah Alaluwayt

Major General Jarallah Alalweet (Arabic: جار الله العلويط) is the current commander of the fifth branch of Royal Saudi Armed Forces: the Royal Saudi Strategic Missile Force. He had officially opened the new HQ and Academy building of Strategic Missile Force in Riyadh during July 2013. Starting from 2013 his name and photos are officially opened for the general public, his personality is not classified as it was used before for all information connected with Royal Saudi Strategic Missile Force.
His post has become even more important since the Nuclear program of Saudi Arabia has been pushed forward from 2009, according to the declarations by King Abdullah of Saudi Arabia and prince Turki bin Faisal Al Saud.
Alaluwayt is probably the first and only commander of such military branch among all Arab and Muslim countries. Pakistan has strategic ballistic missiles too, but they are not a separate branch of the military; the Army Strategic Forces Command is subordinate of Pakistan Army.
# Baroque horse

The term baroque horse describes a group of horse breeds, usually descended from and retaining the distinctive characteristics of a particular type of horse that rose to prominence in Europe during the Baroque era, after significant development throughout the Middle Ages. It describes the type of agile but strong-bodied descendants of horses in the Middle Ages such as the destrier. Specific ancestors of this type include the Neapolitan horse, and the Iberian horse of Barb ancestor known in the Middle Ages as the Spanish Jennet. They are characterized by powerful hindquarters, a muscular, arched neck, a straight or slightly convex profile, and usually a full, thick mane and tail. These horses are particularly well suited for the haute ecole discipline of classical dressage.
Assorted crossbreds developed from these breeds also may attain breed status over time as they develop a breed registry and other indicia of purebred status.
Historically, the destrier was a war horse. In the Renaissance its descendants became trained in the haute ecole discipline of classical dressage. In the modern world, these horses are still seen in modern dressage and continue to perform haute ecole in venues such as the Spanish Riding School and the Cadre Noir. Their build also suits them for sports such as mounted bullfighting.
# Milan Platovsky

Milan Platovsky Stein (1922–2012) was a Czech-Chilean businessman and a Holocaust survivor.
He was born into a Jewish family in Prague. His father, Leo Platovsky, was a businessman. His mother, Rosa Stein, came from the Czech bourgeoisie. He lived a carefree childhood. Following the Nazi occupation of what was then Czechoslovakia, like other Jews he was harassed by the authorities, subjected to forced labour and ultimately sent to extermination camps in Auschwitz and Sachsenhausen. He escaped the Nazis in 1944 and made his way to Paris. There he was reunited with his first cousin Hana Maria Pravda, the only other member of his family to survive the war. He emigrated to Chile from France in 1950, while Hana went to Australia and later to England. They remained close for the next 60 years until Hana's death in 2010. Milan published his biography, Sobrevivir: Memorias de un resiliente, in 1997. It became a best-seller in Chile.