# CASI Pharmaceuticals

CASI Pharmaceuticals, previously known as EntreMed is a US based pharmaceutical company developing medicinal treatments for cancer. The company is primarily known for its producing the angiogenesis inhibitor Endostatin. In 2014 the company was renamed to CASI Pharmaceuticals to focus on products for the treatments of myeloma, leukemia, lymphoma. Wei-Wu He is the present chairman and CEO of the company.

## History and description

EntreMed was co-founded in Rockville in the year 1991 by Peter C. Farrell, Bart Chernow and John Holaday. Holaday was the CEO of the company until 2002. He died in October 2019.

## Endostatin

In May 1998, The New York Times reported a story about a developing drug in the research stage claiming that the same would lead to "eradicate any type of cancer" and "with no obvious side effects". The treatment was supposed to be based on angiostatin and endostatin which was said to work interfering with the supply of blood required by the tumors. It was also said that the tumors are removed with such treatments. Though the report commented on the high expectations already invoked by previous research and prospective candidates its ultimate results were not what was expected. The report also said that the two potential 'weak drugs' had the ability to reduce cancer growth considerably and will be manufactured by EntreMed. The associated research and potential of the drugs and its prospects was proclaimed by the Harvard researcher Dr. Judah Folkman who was known for working to choke off the blood supply to tumor cells for over three decades. James D. Watson stated in reference to the report that "Judah is going to cure cancer in two years". After the NYT story was published, the stock price of EntreMed went up to $83 from $12. During the latter half of that year several uncertainties regarding the effectiveness of the manufacture of the drug was expressed by National Cancer Institute resulting in a drop of Entremed's stock price by $7.75 during November 1998.
Eventually EntreMed partnered with Bristol-Myers Squibb to carry out R&D about the development of the final drug depending on the base angiostain protein. Bristol-Myers Squibb announced its decision not to continue researching the drug next year. Though the CEO of EntreMed said that such an announcement was 'frustrating' and a 'non-event', he said the two companies would continue to work together as per their agreed terms. The drug is still under its process of development even after going through several rounds of clinical trials and tests. The initial trials of the drug failed in traditional ways but still the hope of its prospects remained as claimed by the inventor Dr. Folkman. In 2005, EndoStar, a new variant of the drug Endostatin was introduced by a group of Chinese scientists with the support of Luo Yongzhang, one of the investors of EntreMed. This variation was developed with the aim to carry out the clinical trials on the population of China. Experts have preferred to wait further to study the trials, effects and analyze the outcome before concluding anything decisively.

## Renaming

During June 2014 EntreMed was renamed to CASI pharmaceuticals through the voting process of the shareholders of the company. In the letter to the shareholder, the CEO at that time, Ken K. Ren said "The new name is in furtherance of the remaking of EntreMed and reflects our mission to combat cancer through advanced science and innovation, and also reflects our integrated development strategy in China and North America".
In August 2019, CASI Pharmaceuticals obtained approval for selling Evomela (an injection treatment for patients with multiple Myelom) to the population of China. This was the first product by the company to be sold to the open market despite it being founded in 1991.