# Swimming at the 2022 World Aquatics Championships – Women's 4 × 100 metre medley relay

The Women's 4 × 100 metre medley relay competition at the 2022 World Aquatics Championships was held on 25 June 2022.

## Records

Prior to the competition, the existing world and championship records were as follows.
| World record | United States | 3:50.40 | Gwangju, South Korea | 28 July 2019 |
| Competition record | United States | 3:50.40 | Gwangju, South Korea | 28 July 2019 |

## Results
### Heats

The heats were started at 09:39.
| Rank | Heat | Lane | Nation | Swimmers | Time | Notes |
| 1 | 2 | 4 | Australia | Kaylee McKeown (59.06) Jenna Strauch (1:07.79) Brianna Throssell (57.29) Madison Wilson (52.63) | 3:56.77 | Q |
| 2 | 1 | 6 | Netherlands | Kira Toussaint (59.75) Tes Schouten (1:06.83) Maaike de Waard (57.45) Marrit Steenbergen (53.45) | 3:57.48 | Q |
| 3 | 1 | 3 | Sweden | Hanna Rosvall (1:01.05) Sophie Hansson (1:06.94) Louise Hansson (56.71) Sarah Sjöström (53.11) | 3:57.81 | Q |
| 4 | 2 | 5 | Canada | Ingrid Wilm (59.54) Kelsey Wog (1:08.26) Maggie Mac Neil (57.23) Kayla Sanchez (53.35) | 3:58.38 | Q |
| 5 | 2 | 6 | Italy | Silvia Scalia (1:01.12) Arianna Castiglioni (1:06.29) Elena Di Liddo (57.79) Silvia Di Pietro (54.20) | 3:59.40 | Q |
| 6 | 2 | 3 | China | Peng Xuwei (1:00.29) Yu Jingyao (1:07.70) Zhang Yufei (57.47) Yang Junxuan (54.09) | 3:59.55 | Q |
| 7 | 1 | 4 | United States | Rhyan White (1:00.12) Alexandra Walsh (1:07.60) Natalie Hinds (58.88) Erika Brown (53.46) | 4:00.06 | Q |
| 8 | 2 | 2 | France | Emma Terebo (1:00.77) Adèle Blanchetière (1:08.99) Marie Wattel (57.83) Charlotte Bonnet (53.86) | 4:01.45 | Q |
| 9 | 2 | 1 | Israel | Aviv Barzelay (1:01.65) Anastasia Gorbenko (1:07.02) Lea Polonsky (59.42) Daria Golovaty (55.19) | 4:03.28 | NR |
| 10 | 1 | 2 | Brazil | Stephanie Balduccini (1:03.43) Jhennifer Conceição (1:07.30) Giovanna Diamante (58.37) Ana Carolina Vieira (55.49) | 4:04.59 | |
| 11 | 2 | 7 | South Korea | Lee Eun-ji (1:00.79) Moon Su-a (1:09.56) Jeong So-eun (59.49) Hur Yeon-kyung (55.45) | 4:05.29 | |
| – | 1 | 5 | Great Britain | Medi Harris (1:00.37) Molly Renshaw Laura Stephens Lucy Hope | Disqualified | Disqualified |
| – | 1 | 1 | Thailand | Did not start | Did not start | Did not start |
| – | 1 | 7 | Greece | Did not start | Did not start | Did not start |

### Final

The final was held at 19:38.
| Rank | Lane | Nation | Swimmers | Time |
| | 1 | United States | Regan Smith (58.40) Lilly King (1:05.89) Torri Huske (56.67) Claire Curzan (52.82) | 3:53.78 |
| | 4 | Australia | Kaylee McKeown (58.77) Jenna Strauch (1:05.99) Brianna Throssell (57.19) Mollie O'Callaghan (52.30) | 3:54.25 |
| | 6 | Canada | Kylie Masse (58.39) Rachel Nicol (1:07.17) Maggie Mac Neil (56.80) Penny Oleksiak (52.65) | 3:55.01 |
| 4 | 3 | Sweden | Hanna Rosvall (1:00.72) Sophie Hansson (1:06.20) Louise Hansson (56.38) Sarah Sjöström (52.66) | 3:55.96 |
| 5 | 5 | Netherlands | Kira Toussaint (59.80) Tes Schouten (1:06.60) Maaike de Waard (57.39) Marrit Steenbergen (53.45) | 3:57.24 |
| 6 | 7 | China | Peng Xuwei (59.96) Tang Qianting (1:06.62) Zhang Yufei (57.64) Yang Junxuan (53.51) | 3:57.73 |
| 7 | 2 | Italy | Margherita Panziera (1:00.35) Benedetta Pilato (1:07.00) Elena Di Liddo (57.45) Silvia Di Pietro (54.06) | 3:58.86 |
| 8 | 8 | France | Emma Terebo (1:00.58) Adèle Blanchetière (1:08.34) Marie Wattel (57.79) Charlotte Bonnet (53.23) | 3:59.94 |