OpenLLM-France/wikimedia huggingface dataset:
# MRNA-4157/V940

mRNA-4157/V940 is an mRNA based cancer vaccine encapsulated in solid lipid nanoparticles. The 34 mRNA sequences in mRNA-4157/V940 vaccine were generated by an automated algorithm integrated with workflow based on massive parallel sequencing of tissue generated from cancer patients. As adjuvant therapy, mRNA-4157 monotherapy and in combination with pembrolizumab have been investigated in patients with resected solid tumors (melanoma, bladder carcinoma, HPV negative HNSCC, NSCLC, SCLC, MSI-High, or TMB High cancers). It was also investigated in patients with HNSCC and MSS-CRC.

## Clinical development history

mRNA-4157/V940 was initially developed by Moderna starting in 2017. In May 2018, Moderna and MSD (Merck in US) announced collaboration on further development of the investigational agent. In 2019 Moderna and Merck jointly put mRNA-4157/V940 into clinical trials in combination with Merck's cancer immunotherapy drug pembrolizumab in resected stage IIIB-IV melanoma. In December 2022, Moderna and MSD announced that the study met its endpoint and demonstrated superiority. In February 2023, the Food and Drug Administration granted mRNA-4157/V940 breakthrough status. In April 2023, mRNA-4157 in combination with pembrolizumab received Prime Scheme Designation from the European Medicines Agency.
In the 2023 AACR meeting, Professor Jeffrey S. Weber, the deputy director of the Perlmutter Cancer Center, presented the primary analysis outcome from the open-label, 2:1 randomization phase 2b study. At the pre-specified analysis point when 42 Recurrence-free survival (RFS) events occurred among 157 participants with resected stage IIIC-IV melanoma, 22.4% (24/107) in the mRNA-4157 plus pembrolizumab arm had recurrent disease, and 40% (20/50) in the pembrolizumab arm had recurrent disease, which lead to the well-known saying: mRNA-4157 in combination with pembrolizumab reduced risk by 44% in surgical resected melanoma.
In July 2023, MSD and Moderna initiated the phase III study (study V940-001) evaluating mRNA-4157 in combination with pembrolizumab for adjuvant treatment of patients with resected high-risk stage IIB-stage IV melanoma.
In the meantime, a phase III study of V940 plus Pembrolizumab versus placebo plus pembrolizumab as adjuvant therapy in non-small cell lung cancer patient with resected stage II, IIIA, IIIB (N2) is registered and expected to start at November 2023. Of note, patients received prior neoadjuvant therapy for their current NSCLC diagnosis, or has been treated with any agent directed to stimulatory or coinhibitory T-cell receptor (e.g. PD-1, PD-L1, CTLA-4, et al.) are not allowed to enrolled in the study.

## Mechanism of action

mRNA-4157/V940 is an mRNA based cancer vaccine. When administered, it will produce one of several dozen possible abnormal proteins commonly found in cancerous tissues. The production of those proteins is intended to invoke an immune response. mRNA-4157/V940 is given to patients after their tumors have been sequenced and abnormal proteins identified. The drug is then customized to match a patient's tumor, which makes it an example of personalized medicine.
# South Fork Tenmile Creek (Tenmile Creek tributary)

South Fork Tenmile Creek is a 32.10 mi (51.66 km) long 5th order tributary to Tenmile Creek in Greene County, Pennsylvania.

## Variant names

According to the Geographic Names Information System, it has also been known historically as:
* Ten Mile Creek
* Tenmile Creek

## Course

South Fork Tenmile Creek is formed at the confluence of Claylick Run and Grays Run in Rutan, Pennsylvania, and then flows easterly to join Tenmile Creek at Clarksville.

## Watershed

South Fork Tenmile Creek drains 198.68 square miles (514.6 km$^2$) of area, receives about 41.1 in/year of precipitation, has a wetness index of 298.56 and is about 68% forested.
# C12H17NO2

The molecular formula C$_{12}$H$_{17}$NO$_2$ (molar mass : 207.26 g/mol, exact mass : 207.125929) may refer to:
* 2C-V
* 1,3-Benzodioxolylpentanamine
* Ciclopirox
* EDMA
* Fenobucarb
* Homo-MDMA
* 3,4-Isopropylidenedioxyamphetamine
* MADAM-6
* Methylbenzodioxolylbutanamine
* Methylenedioxydimethylamphetamine
* 3,4-Methylenedioxy-N-ethylamphetamine
* Methylenedioxymethylphentermine
* 4-Methyl-2,5-methoxyphenylcyclopropylamine
* Mexedrone
* Promecarb, used in insecticides
# Aleksandar Ćirković

Aleksandar Ćirković (Serbian Cyrillic: Александар Ћирковић; born 21 September 2001) is a Serbian footballer who plays as a left winger for Ferencvárosi TC.

## Club career

Born in Smederevska Palanka, Ćirković represented FC Admira Wacker Mödling, SC Perchtoldsdorf and ASV Vösendorf as a youth. He first appeared as a senior with Admira's reserves on 5 May 2019, coming on as a second-half substitute in a 0–4 Regionalliga home loss against ASK Ebreichsdorf.
Ćirković scored his first senior goal on 7 June 2019, netting the opener in a 1–1 away draw against SK Rapid Wien II. He made his first team debut on 11 September of the following year, starting in a 1–4 loss at SK Rapid Wien.
On 2 February 2021, after featuring rarely in the main squad, Ćirković was loaned to Serbian SuperLiga side FK Mačva Šabac for the remainder of the season. He scored his first professional goal on 7 March, netting his team's third in a 3–1 home win over FK Proleter Novi Sad, but was unable to avoid the club's relegation.
On 20 July 2021, Ćirković moved to Spain and signed a three-year contract with Primera División RFEF side Gimnàstic de Tarragona. He terminated his contract on 22 December, after failing to feature a single minute for the club.
On 26 August 2022, Ćirković signed a four-year contract with Krylia Sovetov in Russia.
On 30 June 2023, he was loaned to TSC for the 2023–24 season.

### Ferencváros

On 22 January 2025, Ćirković was signed by Hungarian League club Ferencváros.

## Career statistics

    As of 4 August 2024
| Club | Season | League | League | League | Cup | Cup | Continental | Continental | Total | Total |
| Club | Season | Division | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals |
| Admira Wacker II | 2018–19 | Austrian Regionalliga East | 3 | 1 | — | — | — | — | 3 | 1 |
| Admira Wacker II | 2019–20 | Austrian Regionalliga East | 14 | 4 | — | — | — | — | 14 | 4 |
| Admira Wacker II | 2020–21 | Austrian Regionalliga East | 4 | 2 | — | — | — | — | 4 | 2 |
| Admira Wacker II | Total | Total | 21 | 7 | 0 | 0 | 0 | 0 | 21 | 7 |
| Admira Wacker | 2019–20 | Austrian Bundesliga | 0 | 0 | 0 | 0 | — | — | 0 | 0 |
| Admira Wacker | 2020–21 | Austrian Bundesliga | 3 | 0 | 1 | 2 | — | — | 4 | 2 |
| Admira Wacker | Total | Total | 3 | 0 | 1 | 2 | 0 | 0 | 4 | 2 |
| Mačva Šabac | 2020–21 | Serbian SuperLiga | 15 | 1 | — | — | — | — | 15 | 1 |
| Gimnàstic | 2021–22 | Primera División RFEF | 0 | 0 | 0 | 0 | — | — | 0 | 0 |
| Voždovac | 2021–22 | Serbian SuperLiga | 16 | 5 | — | — | — | — | 16 | 5 |
| Voždovac | 2022–23 | Serbian SuperLiga | 5 | 0 | — | — | — | — | 5 | 0 |
| Voždovac | Total | Total | 21 | 5 | 0 | 0 | 0 | 0 | 21 | 5 |
| Krylia Sovetov Samara | 2022–23 | RPL | 12 | 1 | 8 | 2 | — | — | 20 | 3 |
| TSC | 2023–24 | Serbian SuperLiga | 34 | 16 | 1 | 0 | 6 | 1 | 41 | 17 |
| Ferencváros | 2024–25 | Nemzeti Bajnokság | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Career total | Career total | Career total | 106 | 30 | 10 | 4 | 6 | 1 | 122 | 35 |
* ↑ Includes one appearance in UEFA Champions League and five appearances and one goal in UEFA Europa League

## Honours
### Individual

* Serbian SuperLiga Team of the Season: 2023–24
# Emmanuel Matuta

Emmanuel Matuta La Nkenda Nosa (born 22 February 2002) is a Belgian footballer who played as a defensive midfielder for Belgian club Lierse.

## Club career

On 20 January 2022, Matuta signed a contract with Dutch club Groningen until the summer of 2026.

## International career

Born in Belgium, Matuta is of Congolese descent. He is a youth international for Belgium.

## Career statistics
### Club

    As of 17 January 2022
Appearances and goals by club, season and competition :
| Club | Season | League | League | League | Cup | Cup | Continental | Continental | Other | Other | Total | Total |
| Club | Season | Division | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals | Apps | Goals |
| Jong PSV | 2020–21 | Eerste Divisie | 48 | 1 | – | – | – | – | 0 | 0 | 48 | 1 |
| Career total | Career total | Career total | 48 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 48 | 1 |
# Spring Run (Ohio River tributary)

Spring Run is a tributary of Flaugherty Run in Allegheny County, Pennsylvania, in the United States. It is approximately 1.2 miles (1.9 km) long and flows through Crescent, Pennsylvania. The watershed of the stream has an area of 0.4 square miles (1.0 km$^2$).

## Course

Spring Run begins in Crescent, near Brodhead Road. It flows northeast and reaches its confluence with Flaugherty Run.
Spring Run joins Flaugherty Run 650 feet (200 m) upstream of its mouth.

### Tributaries

Spring Run has no named tributaries. However, it does have an unnamed tributary which joins Spring Run about halfway down its length.

## Geography and geology

The elevation near the mouth of Spring Run is 692 feet (211 m) above sea level. The elevation of the stream's source is between 1,000 and 1,040 feet (300 and 320 m) above sea level.

## Watershed

The watershed of Spring Run has an area of 0.4 square miles (1.0 km$^2$).

## History

Spring Run was entered into the Geographic Names Information System on August 2, 1979. Its identifier in the Geographic Names Information System is 1188258.
# USS Fall River (CA-131)

41°42′18″N 71°09′45″W﻿ / ﻿41.7049606°N 71.1624407°W﻿ / 41.7049606; -71.1624407
USS Fall River (CA-131) was a Baltimore-class heavy cruiser of the United States Navy. Launched on 13 August 1944 by the New York Shipbuilding Corporation of Camden, New Jersey, sponsored by Mrs. Alexander C. Murray, wife of Fall River mayor Alexander C. Murray; and commissioned on 1 July 1945, Captain David Stolz Crawford in command.

## Service history

On 31 October 1945, Fall River arrived at Norfolk, out of which she sailed in experimental development operations until 31 January 1946. The cruiser was assigned to JTF 1, organized to conduct Operation Crossroads, atomic weapons tests in the Marshall Islands in the summer of 1946. To prepare for this duty, Fall River sailed to San Pedro, California, where from 16 February to 6 March she was altered to provide flagship accommodations. Arriving at Pearl Harbor on 17 March, she embarked Rear Admiral Frank G. Fahrion, commander of the target vessel's group for the tests, and with him sailed in the Marshalls between 21 May and 14 September.
After west coast training, Fall River served a tour of duty in the Far East as flagship of Cruiser Division 1 from 12 January 1947 to 17 June 1947. Authorized during World War II but completed too late to see service in that conflict, the Fall River was caught in the post-war economizing measures, despite her recent completion and lack of wartime damage. She returned to Puget Sound Navy Yard, where she was placed out of commission in reserve on 31 October 1947. Proposals to convert her into an Albany-class guided missile cruiser were cancelled when sister ship Columbus was determined to be in better material condition. Fall River continued to reside in the reserve fleet until stricken on 19 February 1971, and sold on 28 August 1972 to Zidell Explorations Corp., Portland, Oregon.
The tip of her bow is now on display at Battleship Cove.

## Awards

* American Campaign Medal
* World War II Victory Medal
* Navy Occupation Medal
* China Service Medal
# Chroma III

Chroma III was an American film production company that made a number of movies in the 1980s. The company was established by Ken Dalton, a former actor, and Jeff Begun, who had previously made four films for Roger Corman, including Saturday the 14th. Corman provided seed money for their production company, Chroma III, to make the film independently, serving as an uncredited producer.

## Filmography

* Hardbodies (1984) - distributed by Columbia Pictures
* School Spirit (1985) - distributed by Concorde Pictures
* Hardbodies 2 (1986)
* Vendetta (1986) - distributed by Concorde
* Pretty Smart (1987) - distributed by New World
# TCDD 56701 Class

The TCDD (Turkish Republic Railways) 56701 Class was a class of 2-10-0 steam locomotives.
In 1954 TCCD bought 48 SNCF Class 150.X locomotives which had been made redundant by electrification. These had been built between 1944 and 1946 by various French makers (Batignolles-Châtillon, Fives-Lille, SFCM and Schneider et Cie., to the DRG Class 44 Übergangskriegslokomotive (transitional war locomotive) design, both under German occupation and in the immediate period after Allied liberation.
They were kept in TCCD service until the late 1970s.
# Kim Christensen (shot putter)

Kim Juhl Christensen (born 1 April 1984 in Mariager) is a Danish athlete. He represented Denmark in shot put at the 2012 Summer Olympics.

## Competition record

| Year | Competition | Venue | Position | Notes |
| Representing Denmark |||||
| 2005 | European U23 Championships | Erfurt, Germany | 17th (q) | 15.64 m |
| 2007 | European Indoor Championships | Birmingham, United Kingdom | 19th (q) | 17.36 m |
| 2008 | World Indoor Championships | Valencia, Spain | 17th (q) | 18.26 m |
| 2009 | European Indoor Championships | Turin, Italy | 10th (q) | 19.55 m |
| 2010 | European Championships | Barcelona, Spain | 22nd (q) | 18.20 m |
| 2011 | European Indoor Championships | Paris, France | 15th (q) | 19.16 m |
| 2011 | World Championships | Daegu, South Korea | 16th (q) | 19.74 m |
| 2012 | World Indoor Championships | Istanbul, Turkey | 19th (q) | 18.87 m |
| 2012 | European Championships | Helsinki, Finland | 12th | 19.00 m |
| 2012 | Olympic Games | London, United Kingdom | 27th (q) | 19.13 m |
# Peter Sukovský

Peter Sukovský (born 16 February 1975) is a Slovak football player who currently plays for FK Spartak Brekov.
# 1969 Israeli embassies and El Al attacks

On 8 September 1969, three Israeli linked sites in Europe were attacked by Palestinians with grenades and bombs within minutes of each other. The attacks targeted two Israeli embassies, in Bonn, West Germany and in The Hague, the Netherlands, and El Al airline offices in Brussels, Belgium. Three El Al employees and one customer were wounded in the Brussels attack, while none were hurt in the other attacks.

## Aftermath

In response to the attack, Dutch police guarded the El Al office in Amsterdam, while police reinforcements were sent to Schiphol Airport where passengers boarding El Al and KLM flights for Tel Aviv were searched for weapons to avert a possible new aerial hijacking. The Netherlands' Chief of Protocol also phoned the Israeli Ambassador Shimshon Arad to convey Foreign Minister Joseph Luns' message of shock and outrage over the bombing of the Israeli Embassy.
The attackers were three adult Palestinians accompanied by three Palestinian youths aged 14 to 15 years old. A spokesperson for the Popular Front for the Liberation of Palestine (PFLP) in Amman, Jordan claimed responsibility for the attacks, stating that the attackers were among its "Tiger Cubs". Following the attacks, the PFLP also announced that it now planned an "all-out terrorist campaign against Israeli business organizations abroad."
While the adults fled to Syria via Budapest and East Berlin, the youths took refuge respectively in the Saudi Arabian embassy in Bonn, the Tunisian embassy in Brussels, and the Algerian embassy in The Hague. The adult in Brussels was sentenced to 5 years in prison in absentia, charged with giving hand grenades to two youths, aged 12 and 16 years old, with instructions to throw them into the El Al office. While one of the youths escaped, the other was caught and would be tried behind closed doors at the Brussels Children’s Court. The 15-year-old in The Hague was sentenced to three months in a reformatory school. The youth in Brussels who escaped was reported to have flown to Baghdad with the aid of the Iraqi embassy in Paris.
The attacks have been cited as the first example of the militant use of children for the Palestinian cause, and investigations later found that the youths had been recruited by Fatah.
# Meena Kotwal

Meena Kotwal is an Indian journalist, and the founder of The Mooknayak, an online news channel and website focused on social justice for the Dalit, minority and marginalised people.

## Biography

Meena was raised in a Dalit neighborhood in New Delhi. Her parents earned little from their work as laborers. Meena attended the Indian Institute of Mass Communication, Delhi (2013-14 batch) and studied radio and television journalism. She also attended Jamia Millia Islamia (JMI), Delhi, and Babasaheb Bhimrao Ambedkar University.
Meena had worked as a broadcast journalist at the Hindi language division of the British Broadcasting Corporation (BBC) in New Delhi, India from September 2017 to July 2019. She has said her BBC contract was not renewed after she was outed as Dalit by a colleague and then experienced discrimination, and had her formal complaint denied as lacking "merit or substance" by the BBC.
She also contributes opinion pieces for The Wire, The Print, The Shudra, Youth Ki Awaz and Feminism in India. Her open letter to popular Indian actress Kangana Ranaut was published by The Wire, and the republished in Indian languages and Nepali. She has also worked for National Dastak, an online platform which focuses on the stories of marginalised identities.
On 25 December 2021, she posted an online video of herself burning the Manusmriti. She then began to receive death threats and rape threats, and the Delhi Police registed a FIR about the threats. In January 2022, she explained her reasoning for burning the Manusmriti: "The Manusmriti contains a lot of anti-women and anti-Dalit content. Babasaheb Ambedkar had also burned the Manusmriti, on 25 December 1927. Since then, Ambedkarites have been observing the day as Manusmriti Dahan Divas." In February 2022, the UN Special Rapporteur on Human Rights Defenders and others at the UN wrote to the Indian government to express concern about the threats directed at Kotwal.
She founded The Mooknayak in 2021, and by 2023, employs 10 journalists. She has described it as "a Dalit-centred newsroom." The stories published in The Mooknayak cover issues concerning Dalits and other marginalized groups in India. By March 2023, the related YouTube channel for the online newspaper had 50,000 subscribers.

## Honours and awards

* 2020 Indian Institute of Mass Communication Alumni Association (IIMCAA) Award for Developmental Reporting
* 2020 Indian Institute of Mass Communication Alumni Association (IIMCAA) Award for Investigative Reporting

## Personal life

Meena resides in New Delhi and has a daughter. She is married to Raja Pandey.
# Freewheeling (film)

Freewheeling (Italian: A ruota libera) is a 2000 Italian comedy film written, directed and starred by Vincenzo Salemme.

## Plot

Pericle Caruso lives in Naples and is in a wheelchair because of a bad surgery in the hospital. Pericle intends to sue the rich owner of the clinic: a stingy and cruel baron, and so he falls on purpose for his wife...

## Cast

* Vincenzo Salemme as Pericle Caruso
* Carlo Buccirosso as Mario Pecorella
* Sabrina Ferilli as Silvia
* Manuela Arcuri as Maria Grazia
* Maurizio Casagrande as Lawyer Cardamone
* Massimo Ceccherini as Natalizia
* Nando Paone as Beatrice
# Nagasaki Shinchi Chinatown

Nagasaki Shinchi Chinatown (Japanese: ながさき しんち ちゅうかがい, 長崎新地中華街, Simplified Chinese: 长崎新地中华街) is an area located in Nagasaki, Nagasaki, Japan. Today this area is a shopping strip covering many blocks.
Most of the Chinese members of Nagasaki Chinatown are of Fuzhounese descent. Nagasaki and Fuzhou established ties as sister cities in 1980 to recognize the historical connections between the two cities and Fuzhounese immigrant community.

## History

This area was originally the location of the warehouses of Chinese merchants, who traded goods to Japan from the 15th to 19th centuries. They lived in the 'Chinese residence' (Tojin yashiki) a little to the south-east (today's Kannaimachi 館内町).
The Chinese traders came to Nagasaki because it was the only open port in Japan during the Tokugawa period. The Tokugawa government allowed only Nagasaki to stay open to Chinese and Dutch traders, closing off the rest of Japan to prevent European political influence and the spread of Christianity.
Strict rules were placed on these Chinese traders, forcing them to stay within the precincts of the Tojin yashiki at night. Anyone found outside the area during prohibited times was arrested by the local guard.
# Mahmud Taymur

Mahmud Taymur (16 June 1894–25 August 1973) was a fiction writer. He contributed to several publications.

## Biography

He was born in Cairo on 16 June 1894. into a family famous for literature. His father, Ahmed Taymour (1871-1930) was a well-known writer, who was known for his broad interests in Arab heritage, and he was a researcher in the arts of Arabic language, literature and history. Ahmed Taymur left a great library, which is "Timurid", which is considered an ammunition for researchers to date in the Egyptian Books House, including the anecdotes of books and manuscripts. His brother Muhammad Taymur wrote the first short story in Arabic literature. Mahmud Taymur was among the contributors of Al Katib Al Misri, a Cairo-based literary magazine which was launched in October 1945.
# Søren Wulff Johansson

Søren Wulff Johansson (26 August 1971 – 8 August 2020) was a Danish decathlete. He was the first Danish person to receive a lifetime ban from sport, after failing doping tests for anabolic steroids in 1989 and 1995.
Johansson was a two-time Danish Athletics Championships winner. He was the athletics pentathlon champion in 1994 and the decathlon champion in 1995. His personal best performance in the decathlon was 6982 points.
He was a member of several athletics clubs: Aalborg AK until 1989, Trongården in the 1991/1992 season, Sparta in 1993 and Copenhagen Idræts Forening 1994/1995.

## National titles

* Danish Athletics Championships
** Pentathlon: 1994
** Decathlon: 1995