# 2010 US Open – Mixed doubles

Liezel Huber and Bob Bryan defeated Květa Peschke and Aisam-ul-Haq Qureshi in the final, 6–4, 6–4 to win the mixed doubles tennis title at the 2010 US Open.
Carly Gullickson and Travis Parrott were the defending champions, but lost in the first round to Gisela Dulko and Pablo Cuevas.

## Seeds

* Liezel Huber / Bob Bryan (champions)
* Cara Black / Leander Paes (quarterfinals)
* Katarina Srebotnik / Nenad Zimonjić (second round)
* Bethanie Mattek-Sands / Daniel Nestor (semifinals)
* Rennae Stubbs / Dick Norman (first round)
* Elena Vesnina / Andy Ram (second round)
* Lisa Raymond / Wesley Moodie (quarterfinals)
* Vania King / Horia Tecău (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Liezel Huber Bob Bryan | 6 | 7 | | | | |
| 4 | Bethanie Mattek-Sands Daniel Nestor | 3 | 5 | | | | |
| 4 | Bethanie Mattek-Sands Daniel Nestor | 3 | 5 | 1 | Liezel Huber Bob Bryan | 6 | 6 |
| | | | | | Květa Peschke Aisam-ul-Haq Qureshi | 4 | 4 |
| | Květa Peschke Aisam-ul-Haq Qureshi | 7 | 7 | | Květa Peschke Aisam-ul-Haq Qureshi | 4 | 4 |
| | Anna-Lena Grönefeld Mark Knowles | 6$^5$ | 6$^4$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | L Huber B Bryan | 6 | 6 | | | | | | | | | | | | | | |
| Alt | S-w Hsieh B Soares | 4 | 3 | | 1 | L Huber B Bryan | 5 | 6 | [10] | | | | | | | | |
| WC | M Oudin R Harrison | 6 | 7 | | WC | M Oudin R Harrison | 7 | 1 | [3] | | | | | | | | |
| | A Hlaváčková M Mertiňák | 1 | 5 | | | | | | | 1 | L Huber B Bryan | 6 | 7 | | | | |
| | T Bacsinszky O Marach | 1 | 3 | | | | | | | 7 | L Raymond W Moodie | 4 | 6$^3$ | | | | |
| | O Govortsova M Matkowski | 6 | 6 | | | O Govortsova M Matkowski | 4 | 6$^5$ | | | | | | | | | |
| | A Medina Garrigues M López | 1 | 6$^4$ | | 7 | L Raymond W Moodie | 6 | 7 | | | | | | | | | |
| 7 | L Raymond W Moodie | 6 | 7 | | | | | | | | | | | 1 | L Huber B Bryan | 6 | 7 |
| 4 | B Mattek-Sands D Nestor | 6 | 2 | [10] | | | | | | | | | | 4 | B Mattek-Sands D Nestor | 3 | 5 |
| WC | B Capra J Sock | 2 | 6 | [7] | 4 | B Mattek-Sands D Nestor | 6$^2$ | 6 | [10] | | | | | | | | |
| | Z Yan R Bopanna | 2 | 4 | | | A Rezaï R Ram | 7 | 2 | [5] | | | | | | | | |
| | A Rezaï R Ram | 6 | 6 | | | | | | | 4 | B Mattek-Sands D Nestor | 6 | 6 | | | | |
| | Y-j Chan P Hanley | 6 | 6 | | | | | | | | Y-j Chan P Hanley | 4 | 3 | | | | |
| Alt | A Dulgheru D Marrero | 4 | 2 | | | Y-j Chan P Hanley | 6 | 5 | [10] | | | | | | | | |
| WC | A Spears S Lipsky | 7 | 7 | | WC | A Spears S Lipsky | 2 | 7 | [5] | | | | | | | | |
| 5 | R Stubbs D Norman | 6$^4$ | 6$^3$ | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| 8 | V King H Tecău | 5 | 6 | [5] | | | | | | | | | | | | | |
| | K Peschke A-u-H Qureshi | 7 | 4 | [10] | | K Peschke A-u-H Qureshi | 5 | 6 | [10] | | | | | | | | |
| WC | J Craybas M Russell | 6$^3$ | 7 | [1] | | Y Shvedova J Knowle | 7 | 3 | [4] | | | | | | | | |
| | Y Shvedova J Knowle | 7 | 5 | [10] | | | | | | | K Peschke A-u-H Qureshi | 3 | 6 | [10] | | | |
| WC | C Gullickson T Parrott | 2 | 4 | | | | | | | | G Dulko P Cuevas | 6 | 2 | [4] | | | |
| | G Dulko P Cuevas | 6 | 6 | | | G Dulko P Cuevas | 7 | 7 | | | | | | | | | |
| | A Petkovic M Fyrstenberg | 6$^3$ | 6$^2$ | | 3 | K Srebotnik N Zimonjić | 5 | 5 | | | | | | | | | |
| 3 | K Srebotnik N Zimonjić | 7 | 7 | | | | | | | | | | | | K Peschke A-u-H Qureshi | 7 | 7 |
| 6 | E Vesnina A Ram | 6 | 6$^6$ | [11] | | | | | | | | | | | A-L Grönefeld M Knowles | 6$^5$ | 6$^4$ |
| WC | R Kops-Jones E Butorac | 4 | 7 | [9] | 6 | E Vesnina A Ram | 6 | 3 | [7] | | | | | | | | |
| | A-L Grönefeld M Knowles | 6 | 6 | | | A-L Grönefeld M Knowles | 4 | 6 | [10] | | | | | | | | |
| WC | N Gibbs S Querrey | 3 | 2 | | | | | | | | A-L Grönefeld M Knowles | 6 | 6 | | | | |
| | D Hantuchová M Bhupathi | 4 | 2 | | | | | | | 2 | C Black L Paes | 3 | 4 | | | | |
| | K Kanepi R Lindstedt | 6 | 6 | | | K Kanepi R Lindstedt | 4 | 1 | | | | | | | | | |
| | L Hradecká F Čermák | 4 | 5 | | 2 | C Black L Paes | 6 | 6 | | | | | | | | | |
| 2 | C Black L Paes | 6 | 7 | | | | | | | | | | | | | | |