# Mid-South Conference

The Mid-South Conference (MSC) is a college athletic conference affiliated with the National Association of Intercollegiate Athletics (NAIA). Member institutions are located in Kentucky and Tennessee. The league is headquartered in Bowling Green, Kentucky, and the commissioner is Eric Leach.
The Mid-South Conference has 7 full members: Bethel (TN), Campbellsville, Cumberland (TN), Cumberlands (KY), Freed–Hardeman, Georgetown (KY) and Lindsey Wilson. Six of these members sponsor football; Freed–Hardeman does not.
The Mid-South Conference also has six associate members that compete primarily in other conferences. Faulkner, Kentucky Christian, Union Commonwealth and recently former member Bluefield are associate members of the MSC for football and men's volleyball, and Reinhardt is an associate member of the MSC for football and men's volleyball. This gave the conference 13 members for football. In the spring of 2016, the conference expanded to 20 members, adding the six football members of the Sun Conference, as well as Faulkner University for football, On January 4, 2018, the conference added Keiser University for football, and St. Thomas announced in July they were joining the conference for football in 2019. Another Sun Conference member, Florida Memorial in Miami Gardens, Florida, joined the MSC as an affiliate member for football in 2020, after re-adding the sport.

## History

In April 2018, Thomas More University (then Thomas More College), which had been an NAIA member before moving to NCAA Division III in 1990, announced that it had been formally invited to rejoin the NAIA in the 2019–20 academic year as a member of the Mid-South Conference. The school, while acknowledging that it was considering this move, denied published reports that it had accepted the invitation. Thomas More eventually confirmed in July that it would join the Mid-South in 2019.
In 2020, Bethel University became a Mid-South full member, brought track and field back to the MSC, and transferred all sports other than football and archery to the conference (prior to that, Bethel was an associate member of the MSC for football and archery only); additionally, Freed–Hardeman and UT Southern, then known as Martin Methodist College, also joined Mid-South.
In December 2020, Life University also announced its departure from the MSC for the Southern States Athletic Conference for the 2022–23 academic year.
Most recently, Thomas More announced in August 2021 that it would return to the NCAA, but this time in Division II as a member of the Great Midwest Athletic Conference (G-MAC). It joined the G-MAC as a provisional member in July 2022, but continued as an NAIA member and in the Mid-South through 2022–23, after which it started G-MAC competition. Later, the Sun Conference announced on December 22, 2021, that it would reinstate football starting with the 2022 season. Then in July 2022, the Appalachian Athletic Conference announced it would add football as a sponsored sport.

### Chronological timeline

* 1987 – The Mid-South Conference (MSC) was founded as a football-only conference. Charter members included Campbellsville College (now Campbellsville University), Cumberland College of Kentucky (now the University of the Cumberlands), Georgetown College and Union College (now Union Commonwealth University), beginning the 1987 fall season (1987–88 academic year).
* 1988 – The University of Evansville joined the conference in the 1988 fall season (1988–89 academic year).
* 1989 – Kentucky Wesleyan College and Tennessee Wesleyan University joined the conference in the 1989 fall season (1989–90 academic year).
* 1990 – Kentucky Wesleyan dropped out of the conference after the 1989 fall season (1989–90 academic year).
* 1990 – Cumberland College of Tennessee (now Cumberland University) and Lambuth University joined the Mid-South in the 1990 fall season (1990–91 academic year).
* 1991 – Cumberland [Tenn.] and Tennessee Wesleyan departed from the conference after the 1990 fall season (1990–91 academic year).
* 1991 – Tusculum University joined the Mid-South in the 1991 fall season (1991–92 academic year).
* 1992 – Evansville left the Mid-South after the 1991 fall season (1991–92 academic year).
* 1995 – The Mid-South became a multi-sport conference. North Greenville College (now North Greenville University) joined the conference beginning the 1995–96 academic year, while Bethel College of Tennessee joined as an affiliate member for football (with Cumberland [Tenn.] rejoining as well).
* 1996 – Tusculum departed from the conference as a football affiliate after the 1995 fall season (1995–96 academic year).
* 1996 – Cumberland [Tenn.] and Lambuth moved their other sports to the Mid-South as full members for the 1996–97 academic year.
* 1997 – Bethel [Tenn.] left the Mid-South as an affiliate member for football after the 1996 fall season (1996–97 academic year).
* 2000 – Lindsey Wilson College and Pikeville College (now the University of Pikeville; a.k.a. UPike) joined the Mid-South in the 2000–01 academic year.
* 2001 – North Greenville left the Mid-South to join the Division II ranks of the National Collegiate Athletic Association (NCAA) as an NCAA D-II Independent after the 2000–01 academic year.
* 2002 – Two institutions left the Mid-South as full members to join their respective new home primary conferences, both effective after the 2001–02 academic year; while they remained in the conference as affiliate members for football:
** Cumberland [Tenn.] to the TranSouth Athletic Conference (TranSouth or TSAC)
** and Union Commonwealth to the Appalachian Athletic Conference (AAC)
* 2002 – The University of Virginia's College at Wise (UVa Wise) joined the Mid-South as an affiliate member for football in the 2002 fall season (2002–03 academic year).
* 2003 – Bethel [Tenn.] rejoined the Mid-South as an affiliate member for football in the 2003 fall season (2003–04 academic year).
* 2004 – Kentucky Wesleyan rejoined the Mid-South as an affiliate member for football in the 2004 fall season (2004–05 academic year).
* 2005 – Shorter College of Georgia (now Shorter University) joined the Mid-South as an affiliate member for football in the 2005 fall season (2005–06 academic year).
* 2006 – Lambuth left the Mid-South to join the TranSouth Athletic Conference (TSAC or TranSouth) after the 2005–06 academic year; while their football team remained in the Mid-South as an affiliate member.
* 2006 – Kentucky Wesleyan left the Mid-South again as an affiliate member for football after the 2005 fall season (2005–06 academic year).
* 2006 – West Virginia University Institute of Technology (West Virginia Tech or WVU Tech) joined the Mid-South in the 2006–07 academic year.
* 2007 – Bethel [Tenn.] and Shorter added track & field into their Mid-South affiliate memberships in the 2008 spring season (2007–08 academic year).
* 2008 – St. Catharine College joined the Mid-South in the 2008–09 academic year.
* 2008 – Faulkner University joined the Mid-South as an affiliate member for football in the 2008 fall season (2008–09 academic year).
* 2009 – The University of Rio Grande joined the Mid-South in the 2009–10 academic year.
* 2009 – Two institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), both effective in the 2009–10 academic year:
** Kentucky Christian University for football
** and Cumberland [Tenn.] for men's wrestling
* 2010 – Lambuth left the Mid-South as an affiliate member for football after the 2009 fall season (2009–10 academic year).
* 2010 – Shawnee State University joined the Mid-South (with UVa Wise joining for all sports) in the 2010–11 academic year.
* 2010 – Shorter added men's wrestling into their Mid-South affiliate membership in the 2010–11 academic year.
* 2012 – West Virginia Tech left the Mid-South to become an NAIA Independent (which would later join the Kentucky Intercollegiate Athletic Conference (KIAC; now known as the River States Conference), beginning the 2015–16 school year) after the 2011–12 academic year.
* 2012 – Shorter [Ga.] left the Mid-South as an affiliate member for football, track & field and men's wrestling after the 2011–12 academic year.
* 2012 – Bluefield College (now Bluefield University) joined the Mid-South (with Cumberland [Tenn.] rejoining for all sports) in the 2012–13 academic year.
* 2012 – Bethel [Tenn.] and Union Commonwealth added men's and women's bowling into their Mid-South affiliate memberships in the 2013 spring season (2012–13 academic year).
* 2013 – UVa Wise left the Mid-South and the NAIA entirely to fully align with the NCAA Division II ranks, while joining the Mountain East Conference (MEC) after spending provisionally one season in the Great Midwest Athletic Conference (G-MAC) after the 2012–13 academic year.
* 2013 – Bethel [Tenn.] left the Mid-South as an affiliate member for track & field after the 2013 spring season (2012–13 academic year).
* 2013 – Reinhardt University joined the Mid-South as an affiliate member for football in the 2013 fall season (2013–14 academic year).
* 2014 – Two institutions left the Mid-South to join their respective new home primary conferences, both effective after the 2013–14 academic year:
** Rio Grande to join the KIAC
** Bluefield to rejoin the AAC; while their football team remained in the Mid-South as an affiliate member.
* 2014 – Life University joined the Mid-South in the 2014–15 academic year.
* 2015 – Belhaven left the Mid-South as an affiliate member for football to join the NCAA Division III ranks and the American Southwest Conference after the 2014 spring season (2014–15 academic year).
* 2015 – Eight institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2015–16 academic year:
** Brewton–Parker College, St. Andrews University, Southeastern University of Florida and Truett McConnell College (now Truett McConnell University) for men's wrestling
** Cincinnati Christian University for football
** Lindenwood University–Belleville for men's & women's bowling and men's & women's swimming
** and Martin Methodist College (now the University of Tennessee Southern, a.k.a. UT Southern) and Tennessee Wesleyan College (now Tennessee Wesleyan University) for men's and women's bowling
* 2016 – St. Catherine's left the Mid-South as the school had ceased operations after the 2015–16 academic year.
* 2016 – Three institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2015–16 academic year:
** Loyola University New Orleans for men's and women's swimming
** Reinhardt for men's wrestling
** and Warner University for football
* 2017 – Four institutions left the Mid-South as affiliate members (and/or removed other single sports from their affiliate memberships), all effective after the 2016–17 academic year:
** Reinhardt, St. Andrews [N.C.] and Truett McConnell for men's wrestling after the 2016–17 academic year:
** and Lindenwood–Belleville for men's and women's bowling
* 2017 – Nine institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2017–18 academic year:
** Ave Maria University, Edward Waters College (now Edward Waters University), Point University and St. Andrews [N.C.] for football
** Bethel [Tenn.] for archery
** Brewton–Parker and Lindenwood–Belleville for women's wrestling
** Kentucky Christian for archery, baseball and softball
** and Midland University for men's and women's swimming
* 2018 – Twelve institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2018–19 academic year:
** Ave Maria, Keiser University and Marian University of Indiana for women's lacrosse
** Bluefield, Brewton–Parker, Cincinnati Christian, St. Andrews [N.C.], Warner and Webber International University for men's volleyball
** Indiana Wesleyan University for women's swimming
** Midway University for men's volleyball and men's wrestling
** and Union Commonwealth for archery
* 2019 – Five institutions left the Mid-South as affiliate members (and/or removed other single sports from their affiliate memberships), all effective after the 2018–19 academic year:
** Brewton–Parker for men's volleyball
** Edward Waters for football
** Kentucky Christian for baseball and softball
** Lindenwood–Belleville for women's wrestling and men's and women's swimming
** and Midland for men's and women's swimming
* 2019 – Thomas More University joined the Mid-South in the 2019–20 academic year.
* 2019 – Six institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2019–20 academic year:
** Blue Mountain College (now Blue Mountain Christian University), Marian [Ind.] and Midway for men's and women's bowling
** Reinhardt and Truett McConnell for men's volleyball
** and Keiser for men's wrestling
* 2020 – Cincinnati Christian left the Mid-South as an affiliate member for football and men's volleyball after the 2019 fall semester (without completing the rest of the 2019–20 academic year due to the school having to cease operations).
* 2020 – Freed–Hardeman University joined the Mid-South (with Bethel [Tenn.] and Martin Methodist (now UT Southern) upgrading as full members for all sports) in the 2020–21 academic year.
* 2020 – Nine institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2020–21 academic year:
** Florida Memorial University for football
** Indiana Institute of Technology, Lourdes University and St. Andrews [N.C.] for women's wrestling
** Midway for men's and women's swimming
** the University of Rio Grande for men's and women's swimming, and men's wrestling
** St. Thomas University of Florida for men's wrestling
** Truett McConnell for men's volleyball
** and Webber International for women's lacrosse
* 2021 – Two institutions left the Mid-South as affiliate members (and/or removed other single sports from their affiliate memberships), both effective after the 2020–21 academic year:
** Marian [Ind.] men's and women's bowling
** and Rio Grande for men's and women's swimming
* 2021 – Three institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), all effective in the 2021–22 academic year:
** Indiana Wesleyan for men's swimming
** Lincoln College of Illinois for men's and women's swimming
** and Rio Grande for men's volleyball
* 2022 – Life left the Mid-South to join the Southern States Athletic Conference (SSAC) after the 2021–22 academic year; while their women's wrestling team remained in the Mid-South as an affiliate member.
* 2022 – Seventeen institutions left the Mid-South as affiliate members (and/or removed other single sports from their affiliate memberships), all effective after the 2021–22 academic year:
** Ave Maria for football and women's lacrosse
** Bluefield, Reinhardt, St. Andrews [N.C.] and Warner for football and men's volleyball
** Brewton–Parker for men's wrestling
** Florida Memorial and Southeastern [Fla.] to join The Sun for football
** Keiser for women's lacrosse and men's wrestling
** Kentucky Christian, Point and Union Commonwealth to join the AAC for football
** Lincoln [Ill.] for men's and women's swimming
** Marian [Ind.] for women's lacrosse
** St. Thomas [Fla.] for men's wrestling
** Truett McConnell for men's volleyball
** and Webber International for men's volleyball and women's lacrosse
* 2022 – Wilberforce University joined the Mid-South in the 2022–23 academic year.
* 2022 – Montreat College, Rochester University (now Rochester Christian University) and Siena Heights University joined the Mid-South as affiliate members for women's wrestling in the 2022–23 academic year.
* 2023 – Thomas More left the Mid-South and the NAIA entirely to fully align with the NCAA Division II ranks and the G-MAC after the 2022–23 academic year. During that same school year, they returned to the NCAA to join the G-MAC as a provisional member, while remaining committed to compete in their final season within the Mid-South and the NAIA.
* 2023 – Four institutions left the Mid-South to join their respective new home primary conferences, all effective after the 2022–23 academic year:
** Shawnee State to the RSC; while their men's and women's swimming teams remained in the Mid-South as an affiliate member.
** Pikeville (UPike) to the AAC; while their archery and men's and women's bowling teams remained in the Mid-South as an affiliate member.
** UT Southern to rejoin the SSAC
** and Wilberforce as an NAIA Independent within the Continental Athletic Conference
* 2023 – Two institutions joined the Mid-South as affiliate members (and/or added other single sports into their affiliate memberships), both effective in the 2023–24 academic year:
** Brescia University for men's volleyball
** and Midway for archery
* 2024 – Four institutions left the Mid-South as affiliate members (and/or removed other single sports from their affiliate memberships), all effective after the 2023–24 academic year:
** and Brescia, Midway and Rio Grande for men's volleyball
** St. Andrews [N.C.] for women's wrestling
* 2024 – Rio Grande added women's wrestling into its Mid-South affiliate membership in the 2024–25 academic year.

## Member schools
### Current members

The Mid-South currently has seven full members, all are private schools:
| Institution | Location | Founded | Affiliation | Enrollment | Nickname | Joined |
| Bethel University | McKenzie, Tennessee | 1842 | Cumberland Presbyterian | 2,975 | Wildcats | 2020 |
| Campbellsville University | Campbellsville, Kentucky | 1906 | Baptist | 3,318 | Tigers | 1987 |
| Cumberland University | Lebanon, Tennessee | 1842 | Nonsectarian | 1,345 | Phoenix | 1996; 2012 |
| University of the Cumberlands | Williamsburg, Kentucky | 1889 | Nondenominational | 1,743 | Patriots | 1987 |
| Freed–Hardeman University | Henderson, Tennessee | 1869 | Churches of Christ | 2,050+ | Lions | 2020 |
| Georgetown College | Georgetown, Kentucky | 1829 | Baptist | 1,400 | Tigers | 1987 |
| Lindsey Wilson College | Columbia, Kentucky | 1903 | United Methodist | 2,677 | Blue Raiders | 2000 |

#### Notes

* ↑ Represents the calendar year when fall sports competition begins.
* ↑ Bethel (Tenn.) left the Mid-South after the 1996 fall season (1996–97 season) for football; later rejoined in the 2003 fall season (2003–04 school year). It also added archery during the 2017–18 school year. In the 2020 fall season (2020–21 school year), Bethel moved track & field back to the Mid-South after initially joining as an affiliate from 2007–08 to 2012–13, and transferred all other sports to the conference as a full member.
* ↑ Cumberland (Tenn.) left the Mid-South after the 2001–02 school year to join the TranSouth Athletic Conference (TranSouth); before rejoining the Mid-South, which transferred all other sports to the conference as a full member in the 2012–13 school year

### Affiliate members

The Mid-South currently has 16 associate members. All but one are private schools; the remaining school operates private and public institutions within a single entity.
| Institution | Location | Founded | Affiliation | Enrollment | Nickname | Joined | Mid-South sport(s) | Primary conference |
| Brewton–Parker College | Mount Vernon, Georgia | 1904 | Baptist | 1,050 | Barons | 2017$^{w.wr.}$ | women's wrestling | Southern States (SSAC) |
| Faulkner University | Montgomery, Alabama | 1942 | Churches of Christ | 2,212 | Eagles | 2008 | football | Southern States (SSAC) |
| Indiana Institute of Technology | Fort Wayne, Indiana | 1930 | Nonsectarian | 7,000 | Warriors | 2020 | women's wrestling | Wolverine–Hoosier (WHAC) |
| Indiana Wesleyan University | Marion, Indiana | 1920 | Wesleyan Church | 2,969 | Wildcats | 2018$^{w.sw.}$ 2021$^{m.sw.}$ | women's swimming men's swimming | Crossroads |
| Kentucky Christian University | Grayson, Kentucky | 1919 | Christian | 550 | Knights | 2017 | archery | Appalachian (AAC) |
| Life University | Marietta, Georgia | 1974 | Nonsectarian | 2,800 | Running Eagles | 2022 | women's wrestling | Southern States (SSAC) |
| Lourdes University | Sylvania, Ohio | 1958 | Catholic | 1,500 | Gray Wolves | 2020 | women's wrestling | Wolverine–Hoosier (WHAC) |
| Midway University | Midway, Kentucky | 1847 | Disciples of Christ | 1,800 | Eagles | 2018$^{m.wr.}$ 2019$^{m.bw.}$ 2019$^{w.bw.}$ 2020$^{m.sw.}$ 2020$^{w.sw.}$ 2023$^{arch.}$ | men's wrestling men's bowling women's bowling men's swimming women's swimming archery | River States (RSC) |
| Montreat College | Montreat, North Carolina | 1916 | Presbyterian (PCUSA) | 950 | Cavaliers | 2022 | women's wrestling | Appalachian (AAC) |
| University of Pikeville | Pikeville, Kentucky | 1889 | Presbyterian (PCUSA) | 2,268 | Bears | 2023$^{arch.}$ 2023$^{m.bw.}$ 2023$^{w.bw.}$ | archery men's bowling women's bowling | Appalachian (AAC) |
| University of Rio Grande | Rio Grande, Ohio | 1876 | Hybrid | 1,893 | RedStorm | 2020$^{m.wr.}$ 2024$^{w.wr.}$ | men's wrestling women's wrestling | River States (RSC) |
| Rochester Christian University | Rochester Hills, Michigan | 1959 | Churches of Christ | 1,100 | Warriors | 2022 | women's wrestling | Appalachian (AAC) |
| Shawnee State University | Portsmouth, Ohio | 1986 | Public | 4,300 | Bears | 2023$^{m.sw.}$ 2023$^{w.sw.}$ | men's swimming women's swimming | River States (RSC) |
| Siena Heights University | Adrian, Michigan | 1919 | Catholic (O.P.) | 2,500 | Saints | 2022 | women's wrestling | Appalachian (AAC) |
| Tennessee Wesleyan University | Athens, Tennessee | 1857 | United Methodist | 1,103 | Bulldogs | 2015$^{m.bw.}$ 2015$^{w.bw.}$ | men's bowling women's bowling | Appalachian (AAC) |
| Union Commonwealth University | Barbourville, Kentucky | 1879 | United Methodist | 1,350 | Bulldogs | 2012$^{m.bw.}$ 2012$^{w.bw.}$ 2018$^{arch.}$ | men's bowling women's bowling archery | Appalachian (AAC) |

#### Notes

* ↑ Represents the calendar year when fall sports competition begins.
* ↑ Brewton–Parker competed in the Mid-South as an affiliate member for men's volleyball during the 2019 spring season (2018–19 school year), and for men's wrestling from 2015–16 to 2021–22.
* ↑ Kentucky Christian competed in the Mid-South as an affiliate member for baseball and softball from the 2018 to 2019 spring seasons (2017–18 to 2018–19 school years); and for football from the 2009 to 2021 fall seasons (2009–10 to 2021–22 school years).
* ↑ Life was a full member of the Mid-South from 2014–15 to 2021–22.
* ↑ Midway competed in the Mid-South as an affiliate member for men's volleyball from the 2022 to 2024 spring seasons (2021–22 to 2023–24 school years).
* ↑ Pikeville was a full member of the Mid-South from 2000–01 to 2022–23.
* ↑ Rio Grande was a full member of the Mid-South from 2009–10 to 2013–14.
* ↑ Rio Grande competed in the Mid-South as an affiliate member for men's and women's swimming during the 2020–21 school year, and for men's volleyball from the 2022 to 2024 spring seasons (2021–22 to 2023–24 school years).
* ↑ Rio Grande consists of a public community college and a private, nonsectarian four-year university.
* ↑ Formerly known as Rochester University prior to 2024 and Rochester College prior to 2019.
* ↑ Shawnee State was a full member of the Mid-South from 2010–11 to 2022–23.
* ↑ Tennessee Wesleyan competed in the Mid-South as an affiliate member for football from the 1989 to 1990 spring seasons (1989–90 to 1990–91 school years).
* ↑ Formerly known as Union College until 2024.
* ↑ Union Commonwealth was a full member of the Mid-South from 1995–96 to 2001–02.
* ↑ Union Commonwealth competed in the Mid-South (under its former name of Union) as an affiliate member for football from the 1987 to 1994 and 2002 to 2021 fall seasons (1987–88 to 1994–95 and 2002–03 to 2021–22 school years).

### Former members

The Mid-South has 14 former full members. Ten of these are private schools, and one other operates private and public institutions within a single entity.
| Institution | Location | Founded | Affiliation | Enrollment | Nickname | Joined | Left | Subsequent conference | Current conference |
| Bluefield College | Bluefield, Virginia | 1922 | Baptist | 793 | Rams | 2012 | 2014 | Appalachian (AAC) (2014–present) | Appalachian (AAC) (2014–present) |
| Lambuth University | Jackson, Tennessee | 1843 | United Methodist | N/A | Eagles | 1996 | 2006 | TranSouth (TSAC) (2006–09) NAIA/D-II Independent (2009–11) | Closed in 2011 |
| Life University | Marietta, Georgia | 1974 | Nonsectarian | 2,800 | Running Eagles | 2014 | 2022 | Southern States (SSAC) (2022–present) | Southern States (SSAC) (2022–present) |
| North Greenville College | Tigerville, South Carolina | 1891 | Baptist | 2,100 | Crusaders | 1995 | 2001 | D-II Independent (2001–11) | Carolinas (CC) (2011–present) |
| University of Pikeville | Pikeville, Kentucky | 1889 | Presbyterian (PCUSA) | 2,268 | Bears | 2000 | 2023 | Appalachian (AAC) (2023–present) | Appalachian (AAC) (2023–present) |
| University of Rio Grande | Rio Grande, Ohio | 1876 | Hybrid | 1,893 | RedStorm | 2009 | 2014 | River States (RSC) (2014–present) | River States (RSC) (2014–present) |
| Shawnee State University | Portsmouth, Ohio | 1986 | Public | 4,300 | Bears | 2010 | 2023 | River States (RSC) (2023–present) | River States (RSC) (2023–present) |
| St. Catharine College | St. Catharine, Kentucky | 1873 | Catholic (D.S.P.) | N/A | Patriots | 2008 | 2016 | Closed in 2016 | Closed in 2016 |
| Thomas More University | Crestview Hills, Kentucky | 1921 | Catholic | 1,963 | Saints | 2021 | 2023 | Great Midwest (G-MAC) (2023–present) | Great Midwest (G-MAC) (2023–present) |
| Union Commonwealth University | Barbourville, Kentucky | 1879 | United Methodist | 1,368 | Bulldogs | 1995 | 2002 | Appalachian (AAC) (2002–present) | Appalachian (AAC) (2002–present) |
| University of Tennessee Southern | Pulaski, Tennessee | 1870 | Historically Methodist | 757 | FireHawks | 2020 | 2023 | Southern States (SSAC) (2023–present) | Southern States (SSAC) (2023–present) |
| University of Virginia's College at Wise | Wise, Virginia | 1954 | Public | 2,000 | Highland Cavaliers | 2010 | 2013 | various | South Atlantic (SAC) (2019–present) |
| West Virginia University Institute of Technology | Montgomery, West Virginia | 1895 | Public | 2,252 | Golden Bears | 2006 | 2012 | USCAA/NAIA Independent (2012–15) | River States (RSC) (2015–present) |
| Wilberforce University | Wilberforce, Ohio | 1856 | A.M.E. Church | 900 | Bulldogs | 2022 | 2023 | Continental (2023–24) | HBCU (HBCUAC) (2024–present) |

#### Notes

* ↑ Represents the calendar year when fall sports competition begins.
* ↑ Represents the calendar year when spring sports competition ends.
* ↑ Currently known as Bluefield University since 2021.
* ↑ Lambuth remained in the Mid-South as an affiliate member for football from the 2006 to 2009 fall seasons (2006–07 to 2009–10 school years) and previously from the 1990 to 1995 fall seasons (1990–91 to 1995–96 school years).
* ↑ Life remains in the Mid-South as an affiliate member for women's wrestling.
* ↑ Currently known as North Greenville University since 2006.
* ↑ North Greenville adopted its current nickname of Trailblazers since 2024.
* 1 2 3 4 5 Currently an NCAA Division II athletic conference.
* ↑ Pikeville remains in the Mid-South as an affiliate member for archery and men's & women's bowling.
* ↑ Rio Grande remains in the Mid-South as an affiliate member for men's & women's wrestling.
* ↑ Rio Grande consists of a public community college and a private, nonsectarian four-year university.
* ↑ Shawnee State remains in the Mid-South as an affiliate member for men's and women's swimming.
* ↑ Thomas More left the Mid-South after the 2022–23 school year. Initially the school joined the Great Midwest Athletic Conference (G-MAC) as a provisional member for most sports as a transitional NCAA Division II member school during 2022–23; but was fulfilling its commitments to the final year of competition in the Mid-South and in the NAIA.
* ↑ Formerly known as Union College until 2024.
* ↑ Union Commonwealth competed in the Mid-South (under its former name of Union) as an affiliate member for football from the 2002 to 2021 fall seasons (2002–03 to 2021–22 school years).
* ↑ Union Commonwealth remains in the Mid-South as an affiliate member for archery and men's & women's bowling.
* ↑ UVA Wise previously competed in the Mid-South as an affiliate member for football from the 2002 to 2009 fall seasons (2002–03 to 2009–10 school years).
* ↑ UVA Wise dropped "Highland" from its athletic nickname in 2017.
* 1 2 UVA Wise left the Mid-South after the 2012–13 school year. Originally it joined the Great Midwest Athletic Conference (G-MAC) as a charter member for most sports as a transitional NCAA Division II member school during the 2012–13 school year, but was fulfilling its commitments to the final year of competition in the Mid-South and in the NAIA. However it has never began competition as a full G-MAC member, as it would later announce that it would join the Mountain East Conference (MEC) beginning the 2013–14 school year.
* ↑ UVA Wise had joined the following subsequent conferences: the Great Midwest Athletic Conference (G-MAC) during the 2012–13 school year; and the Mountain East Conference (MEC) from 2013–14 to 2018–19.
* ↑ WVU Tech's campus is now in Beckley, West Virginia, but was in Montgomery during the school's tenure in the Mid-South Conference.
* ↑ Also a Historically black college and university.

### Former affiliate members

The Mid-South had 38 associate members, all but two were private schools:
| Institution | Location | Founded | Affiliation | Enrollment | Nickname | Joined | Left | Mid-South sport(s) | Primary conference |
| Ave Maria University | Ave Maria, Florida | 2003 | Catholic (Diocese of Venice) | 1,200 | Gyrenes | 2017$^{fb.}$ 2018$^{w.lax.}$ | 2022$^{fb.}$ 2022$^{w.lax.}$ | football women's lacrosse | The Sun |
| Belhaven University | Jackson, Mississippi | 1894 | Presbyterian | 3,245 | Blazers | 1998 | 2015 | football | C.C. South (CCS) |
| Bethel University | McKenzie, Tennessee | 1842 | Cumberland Presbyterian | 2,975 | Wildcats | 1996 & 2003$^{fb.}$ 2007$^{t.f.}$ 2012$^{m.bw.}$ 2012$^{w.bw.}$ 2017$^{arch.}$ | 1997 & 2020$^{fb.}$ 2013$^{t.f.}$ 2020$^{m.bw.}$ 2020$^{w.bw.}$ 2020$^{arch.}$ | football track & field men's bowling women's bowing archery | Mid-South (MSC) |
| Bluefield University | Bluefield, Virginia | 1922 | Baptist | 793 | Rams | 2014$^{fb.}$ 2018$^{m.vb.}$ | 2022$^{fb.}$ 2022$^{m.vb.}$ | football men's volleyball | Appalachian (AAC) |
| Blue Mountain College | Blue Mountain, Mississippi | 1873 | Baptist | 505 | Toppers | 2019$^{m.bw.}$ 2019$^{w.bw.}$ | 2022$^{m.bw.}$ 2022$^{w.bw.}$ | men's bowling women's bowling | Southern States (SSAC) |
| Brescia University | Owensboro, Kentucky | 1925 | Catholic (Ursulines) | 1,100 | Bearcats | 2023 | 2024 | men's volleyball | River States (RSC) |
| Brewton–Parker College | Mount Vernon, Georgia | 1904 | Baptist | 1,050 | Barons | 2015$^{m.wr.}$ 2018$^{m.vb.}$ | 2022$^{m.wr.}$ 2019$^{m.vb.}$ | men's volleyball | Southern States (SSAC) |
| Cincinnati Christian University | Cincinnati, Ohio | 1924 | Christian | N/A | Eagles | 2015$^{fb.}$ 2018$^{m.vb.}$ | 2020$^{fb.}$ 2019$^{m.vb.}$ | football men's volleyball | N/A |
| Cumberland University | Lebanon, Tennessee | 1842 | Nonsectarian | 1,345 | Bulldogs | 1990 & 2002;$^{fb.}$ 2009$^{m.wr.}$ | 1991 & 2012;$^{fb.}$ 2012$^{m.wr.}$ | football men's wrestling | Mid-South (MSC) |
| Edward Waters University | Jacksonville, Florida | 1866 | AME Church | 966 | Tigers | 2017 | 2019 | football | Southern (SIAC) |
| University of Evansville | Evansville, Indiana | 1854 | United Methodist | 2,500 | Purple Aces | 1988 | 1992 | football | Missouri Valley (MVC) |
| Florida Memorial University | Miami Gardens, Florida | 1879 | Baptist | 1,784 | Lions | 2020 | 2022 | football | The Sun |
| Keiser University | West Palm Beach, Florida | 1977 | Nonsectarian | 16,760 | Seahawks | 2018$^{w.lax.}$ 2019$^{m.wr.}$ | 2022$^{w.lax.}$ 2022$^{m.wr.}$ | women's lacrosse men's wrestling | The Sun |
| Kentucky Christian University | Grayson, Kentucky | 1919 | Christian | 550 | Knights | 2009$^{fb.}$ 2017$^{bsb.}$ 2017$^{sfb.}$ | 2022$^{fb.}$ 2019$^{bsb.}$ 2019$^{sfb.}$ | football baseball softball | Appalachian (AAC) |
| Kentucky Wesleyan College | Owensboro, Kentucky | 1858 | United Methodist | 830 | Panthers | 1989; 2004 | 1990; 2006 | football | Great Midwest (G-MAC) |
| Lambuth University | Jackson, Tennessee | 1843 | United Methodist | N/A | Eagles | 1990; 2006 | 1995; 2010 | football | Closed in 2011 |
| Lincoln College | Lincoln, Illinois | 1865 | Nonsectarian | 800 | Lynx | 2021$^{m.sw.}$ 2021$^{w.sw.}$ | 2022$^{m.sw.}$ 2022$^{w.sw.}$ | men's swimming women's swimming | Closed in 2022 |
| Lindenwood University–Belleville | Belleville, Illinois | 2003 | Catholic | N/A | Lynx | 2015$^{m.bw.}$ 2015$^{w.bw.}$ 2015$^{m.sw.}$ 2015$^{w.sw.}$ 2017$^{w.wr.}$ | 2017$^{m.bw.}$ 2017$^{w.bw.}$ 2019$^{m.sw.}$ 2019$^{w.sw.}$ 2019$^{w.wr.}$ | men's bowling women's bowling men's swimming women's swimming women's wrestling | Closed in 2020 |
| Loyola University New Orleans | New Orleans, Louisiana | 1904 | Catholic (Jesuit) | 4,858 | Wolf Pack | 2016$^{m.sw.}$ 2016$^{w.sw.}$ | 2022$^{m.sw.}$ 2022$^{w.sw.}$ | men's swimming women's swimming | Southern States (SSAC) |
| Marian University | Indianapolis, Indiana | 1851 | Catholic (S.S.F.) | 3,595 | Knights | 2018$^{w.lax.}$ 2019$^{m.bw.}$ 2019$^{w.bw.}$ | 2022$^{w.lax.}$ 2021$^{m.bw.}$ 2021$^{w.bw.}$ | women's lacrosse men's bowling women's bowling | Crossroads |
| Martin Methodist College | Pulaski, Tennessee | 1870 | Public | 1,000 | RedHawks | 2015$^{m.bw.}$ 2015$^{w.bw.}$ | 2020$^{m.bw.}$ 2020$^{w.bw.}$ | men's bowling women's bowling | Mid-South (MSC) |
| Midland University | Fremont, Nebraska | 1883 | Lutheran ELCA | 1,394 | Warriors | 2017$^{m.sw.}$ 2017$^{w.sw.}$ | 2019$^{m.sw.}$ 2019$^{w.sw.}$ | men's swimming women's swimming | Great Plains (GPAC) |
| Midway University | Midway, Kentucky | 1847 | Disciples of Christ | 1,800 | Eagles | 2018 | 2024 | men's volleyball | River States (RSC) |
| Point University | West Point, Georgia | 1937 | Christian | 1,450 | Skyhawks | 2017 | 2022 | football | Appalachian (AAC) |
| Reinhardt University | Waleska, Georgia | 1883 | United Methodist | 1,057 | Eagles | 2013$^{fb.}$ 2016$^{m.wr.}$ 2019$^{m.vb.}$ | 2022$^{fb.}$ 2017$^{m.wr.}$ 2022$^{m.vb.}$ | football men's wrestling men's volleyball | Appalachian (AAC) |
| University of Rio Grande | Rio Grande, Ohio | 1876 | Nonsectarian | 1,893 | RedStorm | 2020$^{m.sw.}$ 2020$^{w.sw.}$ 2021$^{m.vb.}$ | 2021$^{m.sw.}$ 2021$^{w.sw.}$ 2024$^{m.vb.}$ | men's swimming women's swimming men's volleyball | River States (RSC) |
| St. Andrews University | Laurinburg, North Carolina | 1896 | Presbyterian (PCUSA) | 600 | Knights | 2015$^{m.wr.}$ 2017$^{fb.}$ 2018$^{m.vb.}$ 2020$^{w.wr.}$ | 2017$^{m.wr.}$ 2022$^{fb.}$ 2022$^{m.vb.}$ 2024$^{w.wr.}$ | men's wrestling football men's volleyball women's wrestling | Appalachian (AAC) |
| St. Thomas University | Miami Gardens, Florida | 1961 | Catholic (Archdiocese of Miami) | 4,674 | Bobcats | 2020 | 2022 | men's wrestling | The Sun |
| Shorter University | Rome, Georgia | 1873 | Baptist | 1,520 | Hawks | 2005$^{fb.}$ 2007$^{t.f.}$ 2010$^{m.wr.}$ | 2012$^{fb.}$ 2012$^{t.f.}$ 2012$^{m.wr.}$ | football track & field men's wrestling | Gulf South (GSC) |
| Southeastern University | Lakeland, Florida | 1935 | Assemblies of God | 7,000 | Fire | 2015 | 2022 | men's wrestling | The Sun |
| Tennessee Wesleyan University | Athens, Tennessee | 1857 | United Methodist | 1,103 | Bulldogs | 1989 | 1991 | football | Appalachian (AAC) |
| Truett McConnell University | Cleveland, Georgia | 1946 | Baptist | 1,600 | Eagles | 2015$^{m.wr.}$ 2019$^{m.vb.}$ | 2017$^{m.wr.}$ 2022$^{m.vb.}$ | men's wrestling men's volleyball | Appalachian (AAC) |
| Tusculum University | Tusculum, Tennessee | 1794 | Presbyterian | 2,053 | Pioneers | 1991 | 1996 | football | South Atlantic (SAC) |
| Union Commonwealth University | Barbourville, Kentucky | 1879 | United Methodist | 1,350 | Bulldogs | 1987; 2002 | 1995; 2022 | football | Appalachian (AAC) |
| University of Virginia's College at Wise | Wise, Virginia | 1954 | Public | 2,000 | Highland Cavaliers | 2002 | 2010 | football | South Atlantic (SAC) |
| Warner University | Lake Wales, Florida | 1968 | Church of God | 1,037 | Royals | 2016$^{fb.}$ 2018$^{m.vb.}$ | 2022$^{fb.}$ 2022$^{m.vb.}$ | football men's volleyball | The Sun |
| Webber International University | Babson Park, Florida | 1927 | Nonsectarian | 616 | Warriors | 2018$^{m.vb.}$ 2020$^{w.lax.}$ | 2022$^{m.vb.}$ 2022$^{w.lax.}$ | men's volleyball women's lacrosse | The Sun |

#### Notes

* ↑ Represents the calendar year when fall sports competition begins.
* ↑ Represents the calendar year when spring sports competition ends.
* ↑ Currently an NCAA Division III athletic conference.
* ↑ Bethel (Tenn.) rejoined the Mid-South during the 2020–21 school year and transferred all other sports to the conference as a full member.
* ↑ Bluefield was a full member of the Mid-South from 2012–13 to 2013–14.
* ↑ Currently known as Blue Mountain Christian University since 2022.
* ↑ Brewton–Parker remains in the Mid-South as an affiliate member for women's wrestling.
* 1 2 3 Cincinnati Christian closed at the end of the 2019 fall semester, without completing the rest of the 2019–20 school year.
* ↑ Cumberland (Tenn.) was a full member of the Mid-South 1995–96 to 2001–02, before rejoining the Mid-South in the 2012–13 school year.
* ↑ Cumberland (Tenn.) changed its nickname from Bulldogs to Phoenix in 2016.
* 1 2 3 4 5 6 Currently an NCAA Division II athletic conference.
* 1 2 Currently an NCAA Division I conference.
* ↑ During their tenure as a football-only member, Evansville's primary conference home was the Midwestern Collegiate Conference (now known as the Horizon League).
* ↑ Kentucky Christian remains in the Mid-South as an affiliate member for archery.
* ↑ During their tenure as a football-only member, Kentucky Wesleyan's primary conference home was the Great Lakes Valley Conference (GLVC).
* ↑ Lambuth was a full member of the Mid-South from 1995–96 to 2005–06.
* ↑ Martin Methodist joined the Mid-South during the 2020–21 school year and transferred all other sports to the conference as a full member. In July 2021, Martin Methodist joined the University of Tennessee system to become the University of Tennessee Southern.
* ↑ Martin Methodist (now UT Southern) changed its nickname from RedHawks to FireHawks in 2021.
* ↑ Midway remains in the Mid-South as an affiliate member for men's wrestling, men's & women's bowling, men's & women's swimming and archery.
* ↑ Rio Grande was a full member of the Mid-South from 2009–10 to 2013–14; but still remains in the Mid-South as an affiliate member for men's & women's wrestling.
* ↑ Tennessee Wesleyan remains in the Mid-South as an affiliate member for men's & women's bowling.
* ↑ Formerly known as Union College until 2024.
* ↑ Union Commonwealth was a full member of the Mid-South from 1995–96 to 2001–02; but still remains in the Mid-South as an affiliate member for archery and men's & women's bowling.
* ↑ UVA Wise later became a full member of the Mid-South from 2010–11 to 2012–13
* ↑ UVA Wise dropped "Highland" from its athletic nickname in 2017.

### Membership timeline

Full member (all sports)   Full member (non-football)   Associate member (football only)   Associate member (sport)

## Sports

Member teams compete in 28 sports: 13 men's, 13 women's and 2 mixed.
Conference sports :
| Sport | Men's | Women's | Mixed |
| Archery | | | Y |
| Baseball | Y | | |
| Basketball | Y | Y | |
| Bowling | Y | Y | |
| Cheerleading | | | Y |
| Cross Country | Y | Y | |
| Football | Y | | |
| Golf | Y | Y | |
| Lacrosse | | Y | |
| Soccer | Y | Y | |
| Softball | | Y | |
| Swimming | Y | Y | |
| Tennis | Y | Y | |
| Track & Field Indoor | Y | Y | |
| Track & Field Outdoor | Y | Y | |
| Volleyball | Y | Y | |
| Wrestling | Y | Y | |
In addition, the Mid-South Conference also conducts championships for Esports and competitive dance. The MSC also stages invitational tournaments for junior varsity squads in the sports of men's and women's basketball, baseball, softball, and women's volleyball, if enough schools sponsor JV teams in a given year.

### Football divisions

Beginning with the 2017 season, The Sun Conference and Mid-South merged their football conferences into the largest football conference in college sports. Edward Waters was previously a full member of the Sun Conference from 2006 to 2010 and a football affiliate member from 2014 to 2016 seasons. Edward Waters left after the 2018 football season.
However, the Sun Division folded when its teams left the Mid-South after the Sun Conference reinstated football for 2022, leaving the Mid-South with 15 football members. Later, the Appalachian Division folded when the AAC announced to sponsor the sport for the 2022 fall season, leaving the Mid-South with 9 football members.
* Bethel (Tenn.)$^*$
* Campbellsville$^*$
* Cumberland (Tenn.)$^*$
* Cumberlands (Ky.)$^*$
* Faulkner$^{**}$
* Georgetown$^*$
* Lindsey Wilson$^*$
* Pikeville$^*$
* Thomas More$^*$

#### Notes

$^*$ - Mid-South full member $^{**}$ - Mid-South affiliate member