OpenLLM-France/wikimedia huggingface dataset:
# Methoclocinnamox

Methoclocinnamox (MCCAM; developmental code name NIH-10420) is a selective pseudo-irreversible partial agonist of the μ-opioid receptor (MOR). It shows a mixture of opioid agonist- and antagonist-like effects. The drug has long-lasting effects and is insurmountable by other MOR ligands.
MCCAM was derived from clocinnamox (CCAM), was first described by 1995, and was of interest in the potential treatment of opioid dependence. However, it was not further developed and was never marketed. A close analogue of MCCAM, methocinnamox (MCAM), which in contrast to MCCAM acts as a MOR pseudo-irreversible antagonist, was first described in 2000 and is under development for the treatment of opioid use disorder and opioid overdose as of 2023.

## Pharmacology
### Pharmacodynamics

MCCAM acts as a selective pseudo-irreversible partial agonist of the μ-opioid receptor (MOR). It shows both opioid agonist- and antagonist-like effects in animals. More specifically, it has analgesic effects, mixed reinforcing effects, appears to lack significant respiratory depression, alleviates opioid withdrawal symptoms, and provides long-lasting blockade and protection against the effects of MOR full agonists (including their reinforcing effects as well as their toxic and lethal effects, for instance in overdose). Due to its pseudo-irreversible nature, MCCAM is insurmountable by conventional reversible MOR ligands, for instance morphine, alfentanil, and naltrexone. MCCAM is buprenorphine-like in many regards, but differs from buprenorphine in its pseudo-irreversibility.

### Pharmacokinetics

MCCAM is known to be partially metabolically converted into clocinnamox (CCAM), a MOR pseudo-irreversible antagonist. In monkeys, with oral administration of MCCAM, 70 to 80% of the drug is eliminated as conjugated CCAM, whereas with subcutaneous injection, up to 70% of the drug is excreted unchanged. As such, the metabolism of MCCAM, and by extension its effects, differ by route of administration. The metabolism of MCCAM also shows species differences between rodents and monkeys.

## Chemistry

MCCAM, also known as O-methylclocinnamox, is structurally related to the MOR irreversible antagonists clocinnamox (CCAM) and methocinnamox (MCAM). CCAM and its analogues were derived by structural modification of buprenorphine.

## History

Clocinnamox (CCAM) was first described in the scientific literature by 1992. MCCAM was first described by 1995. It was developed by researchers at the National Institute on Drug Abuse (NIDA) of the United States National Institutes of Health (NIH). The drug was of interest in the possible treatment of opioid dependence. However, it was never marketed. Methocinnamox (MCAM), a close analogue of MCCAM, was first described in 2000. MCAM was under development for the treatment of opioid dependence and opioid overdose by 2020.
# Bromadoline

Bromadoline (U-47931E) is an opioid analgesic selective for the μ-opioid receptor developed by the Upjohn company in the 1970s. The drug has a potency lying between that of codeine and morphine, being slightly stronger than pentazocine. Bromadoline is related to AH-7921 and U-47700.
# Phenaridine

Phenaridine (2,5-dimethylfentanyl) is an opioid analgesic that is an analogue of fentanyl. It was developed in 1972, and is used for surgical anasthesia.
Phenaridine has similar effects to fentanyl. It is slightly less potent than fentanyl in rats. Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Irresponsible use of fentanyl analogues administrated in several times larger doses than recommended, have ended up in a death of hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.
# LiveMath

LiveMath is a computer algebra system available on a number of platforms including Mac OS, macOS (Carbon), Microsoft Windows, Linux (x86) and Solaris (SPARC). It is the latest release of a system that originally emerged as Theorist for the "classic" Mac in 1989, became MathView and MathPlus in 1997 after it was sold to Waterloo Maple, and finally LiveMath after it was purchased by members of its own userbase in 1999. The application is currently owned by MathMonkeys of Cambridge, Massachusetts. The overall LiveMath suite contains LiveMath Maker, the main application, as well as LiveMath Viewer for end-users, and LiveMath Plug-In, an ActiveX plugin for browsers, which was discontinued in 2014.

## Description

LiveMath uses a worksheet-based approach, similar to products like Mathematica or MathCAD. The user enters equations into the worksheet and then uses the built-in functions to help solve them, or reduce them numerically. Workbooks typically contain a number of equations separated into sections, along with data tables, graphs, and similar outputs. Unlike most CAS applications, LiveMath uses a full GUI with high-quality graphical representations of the equations at every step, including input.
LiveMath also allows the user to interact with the equation in the sheet; for instance, one can drag an instance of $x$ to the left hand side of the equation, at which point LiveMath will re-arrange the equation to solve for $x$. LiveMath's algebraic solving systems are relatively simple compared to better known systems like Mathematica, and does not offer the same sort of automated single-step solving of these packages.
# Startforth

Startforth is a village on the Pennines end of south Teesdale, England. The population of Startforth taken at the 2011 Census was 1,361. It was in the historic North Riding of Yorkshire. Along with the rest of the former Startforth Rural District, it was transferred to County Durham for administrative and ceremonial purposes on 1 April 1974, under the provisions of the Local Government Act 1972.
It is situated south-west of Barnard Castle, north of the River Tees. Located in the village is Deerbolt Prison, a male juveniles' prison and Young Offenders Institution.

## History

The place-name 'Startforth' is first attested circa 1050, when it appears as Stretford. It is mentioned in the Domesday Book of 1086 as Stradford. The name means 'street-ford', and refers to the paved ford by which the Roman road which passes through the village crosses the River Tees. The Roman road in question here linked the Roman forts of Bowes and Binchester. The paved ford is still visible in the bed of the river when the water is low.

## Education

Startforth used to have one primary school, Startforth Morritt Memorial Church of England School, but it was closed after a vote by councillors in September 2016.
# Peterborough Rural District

52°34′12″N 0°14′38″W﻿ / ﻿52.570°N 0.244°W﻿ / 52.570; -0.244
Peterborough was a rural district adjoining the city and municipal borough of Peterborough, England, from 1894 to 1974. The council offices were at 51 Priestgate, in the city of Peterborough.
The rural district was created under the Local Government Act 1894, from the part of the Peterborough rural sanitary district that was in the administrative county of Soke of Peterborough (the rest, in Huntingdonshire, formed the Norman Cross Rural District).
In 1929 the city's boundaries were extended, with six of the rural district's parishes being absorbed.
Local government reorganisation abolished the Soke in 1965 and the rural district was transferred to the new administrative county of Huntingdon and Peterborough. The rural district was abolished under the Local Government Act 1972, becoming part of the Peterborough district of the new non-metropolitan county of Cambridgeshire.

## Civil parishes

The rural district consisted of the following civil parishes:
* Ailsworth
* Borough Fen
* Castor
* Deeping Gate
* Etton
* Eye
* Glinton
* Gunthorpe (absorbed by the City of Peterborough in 1929)
* Helpston
* Longthorpe (created 1908 from part of Peterborough Without CP: absorbed by the City of Peterborough in 1929)
* Marholm
* Maxey
* Newborough
* Northborough
* Paston (absorbed by the City of Peterborough in 1929)
* Peakirk
* Peterborough Without (absorbed by the City of Peterborough in 1929)
* Sutton
* Upton
* Walton (absorbed by the City of Peterborough in 1929)
* Werrington (absorbed by the City of Peterborough in 1929)
# Delišimunović

The Delišimunović family is a Croatian noble family originating from Klis Fortress in Split, where they were members of the Uskok military group. They served on the military frontier of the Habsburg Monarchy, later part of the Austro-Hungarian Empire.

## History

The Delišimunović family name has appeared in various forms, including Delisimonovich, Dellisimunovich, Delljsimonovich, and Dellissimunovich. The surname translates to "Son of Simon the Brave" derived from the nickname Delija Šimun, linked to Šimun Radojčić, the son of Ivan Radojčić.
The family initially resided in Klis Fortress before moving to Pokuplje, where they owned Radojčić Castle near Duga Resa. They later relocated to the Žumberak mountains, where Krsto Delišimunović was granted the title of Baron by Leopold I on August 9, 1675. He served as captain of Karlovac until his death in 1696.
Franjo Krsto Delišimunović, son of Krsto, commanded the Croatian army alongside Franjo Vragović during the uprising of Francis II Rákóczi in 1704. He was elevated to the title of Count in 1708.
The family owned properties in Žumberak, including Žumberak Castle, Radojčić Castle, Kostanjevac, and Petričko Selo, as well as southern estates such as Brlog and Drežnik, which they acquired through marriage.

## Notable Members

* Šimun Radojčić (16th century), Castellan of Klis
* Franjo Delišimunović (17th century), Commander of Žumberak
* Krsto Delišimunović (1625 - 1696), Baron and Vice-General
* Franjo Krsto Delišimunović (1655 - 1712), Count and General who participated in the creation of the Croatian Pragmatic Sanction
# Ultraviolet (disambiguation)

Ultraviolet refers to electromagnetic radiation with a wavelength shorter than that of visible light, but longer than soft X-rays.
Ultraviolet, UltraViolet, or Ultra Violet may also refer to:

## Film and television

* Ultraviolet (TV serial), a 1998 British television miniseries
* Ultraviolet (film), a 2006 science fiction film
** Ultraviolet (novel), a 2006 novel adapted from the film
** Ultraviolet: Code 044, a 2008 Japanese anime based on the film
* Ultraviolet (2017 TV series), a Polish television series
* Ultraviolet (Arrowverse), Esperanza Garcia, a character from the TV series The Flash
* Ultra Violet, Violet Rodriguez, the titular heroine from the 2022 TV series Ultra Violet & Black Scorpion

## Music
### Album

* Ultraviolet (All About Eve album), 1992
* Ultraviolet (EP), a 2014 EP by Owl City
* Ultraviolet (Kelly Moran album), 2018
* Ultraviolet (Kid Sister album), 2009
* Ultraviolet (Kirsten Morrell album), 2010
* Ultraviolet (Kylesa album), 2013
* Ultraviolet (Misery Signals album), 2020
* Ultraviolet (Poets of the Fall album), 2018
* Ultraviolet (Pseudo Echo album), 2014, or the title track
* Ultraviolet (Sadistik album), 2014
* Ultra Violet (Bananarama album), 1995
* Ultraviolet, a 1994 album by Ed Alleyne-Johnson, or the title track
* Houseworks Presents Ultraviolet, a 2002 album by DJ Antoine; see DJ Antoine discography

### Song

* "Ultraviolet"/"The Ballad of Paul K", a 2005 single by McFly
* "Ultraviolet (Light My Way)", a 1991 song by U2
* "Ultraviolet" (Fred V & Grafix song), 2016
* "Ultraviolet", a 1978 song by Romano Musumarra and Claudio Gizzi from Automat
* "Ultraviolet", a 2001 song by Annetenna from Annetenna
* "Ultraviolet", a 2003 song by Karl Bartos from Communication
* "Ultraviolet", a 2006 song by Joanna Pacitti from This Crazy Life
* "Ultraviolet", a 2008 song by the B-52's from Funplex
* "Ultraviolet", a 2008 cover of the Pacitti song by Stiff Dylans for the film Angus, Thongs and Perfect Snogging
* "Ultraviolet", a 2010 song by Miami Horror from Illumination
* "Ultraviolet", a 2013 song by FKA twigs from EP2
* "Ultraviolet", a 2013 song by Erra from Augment
* "Ultraviolet", a 2023 song by Spiritbox from The Fear of Fear

## Other uses

* Ultra Violet (Ninjago), a character in Ninjago
* Ultra Violet (Isabelle Collin Dufresne), French-American artist and author
* UltraViolet (organization), a women's advocacy group in the United States
* UltraViolet (website), a digital rights authentication and cloud-based licensing system
# Pancham (svara)

Pancham or panchama is the fifth svara from the seven svaras of Hindustani music and Carnatic music. Pancham is the long form of the syllable प. For simplicity in pronouncing while singing the syllable, Pancham is pronounced as Pa (notation - P). It is also called as पंचम in the Devanagri script.

## Details

Regarding panchama and its importance in Indian classical music:
* Pancham is the fifth svara in an octave or Saptak.
* Pancham is the immediate next svara of Madhyam (Ma).
* The svara of Pancham is never Komal
* It is said that Shadja is the basic svara from which all the other 6 svaras are produced. When we break the word Shadja then we get, Shad And Ja. It means that Shad is 6 and ja is 'giving birth' in Sanskrit. So basically the translation is :
So the svara Pa is formed from Shadja.
* The frequency of Pancham is 360 Hz. The frequencies of the seven svaras are also given below: Sa 240 Hz, Re 270 Hz, Ga 300 Hz, Ma 320 Hz, Pa 360 Hz, Dha 400 Hz, and Ni 450 Hz, Sa 480 Hz (Taar Saptak) ........ (and so on).
Consequently, the Pa after the Ma of 640 Hz (Taar Saptak) has a frequency of 720 Hz i.e. the double of the Lower octave Pa.
* There are 4 Shruti of Pancham. Previously the main Shruti not only for Pa but for all the other svaras was on the last Shruti but now it is considered to be on the 1st Shurti.
For example, if these are the 4 Shruti's of Pa then,
* All the other svaras except Shadja (Sa) and Pancham (Pa) can be Komal or Tivra svaras but Sa and Pa are always Shuddha svaras. And hence svaras Sa and Pa are called Achal Svaras since these svaras don't move from their original position. Svaras Ra, Ga, Ma, Dha, Ni are called Chal Svaras, since these svaras move from their original position.
* Ragas where Pa is the Vadi svara - Raga Nat Bhairav, etc. Ragas where Pa is the Samvadi svara - Raga Brindabani Sarang, etc.
* Hypothetically speaking, Pa is said to be the Praja, Praja as in, the three main gods, Bhrama, Vishnu and Shiva were first created i.e. Sakar Bhrama (Sa) and then these three gods created Rishimuni i.e. Re and then Gandharvas were created for singing and then lord Indra or Raja Indra i.e. Mahipal was created and once the Mahipal (Raja) or the king was created, the Praja or the common citizens or the people were made. Pa is made the acronym of Praja or the common people for showing the importance of the syllable Pa.
* Pancham is said to be sourced from call of the cuckoo.
* Pancham is associated with the planet Saturn.
* Pancham is associated with Blue or Black colour.
# Jek Yeun Thong

Jek Yeun Thong DUNU (Chinese: 易润堂; pinyin: Yì Rùntáng; 29 July 1930 – 3 June 2018) was a Singaporean politician who served as Minister for Science and Technology between 1976 and 1977, Minister for Culture between 1968 and 1977 and Minister for Labour between 1963 and 1968.

## Political career

In 1955, Jek's foray into politics began when he assisted the People's Action Party (PAP) during the 1955 general election. He was appointed to the party's Central Executive Committee (CEC) as a political secretary in 1957. That same year, due to his communist beliefs, he was detained under the Internal Security Act by Lim Yew Hock's government.
He was eventually released and when the PAP formed the Government, he held the posts of Assistant Treasurer and then Treasurer on the Central Executive Committee of the PAP between 1959 and 1976. Apart from serving as the deputy chairman of the People's Association (PA), he also served as Minister of Culture for 12 years between 1968 and 1978.
Additionally, he also served as Minister for Science and Technology between 1976 and 1977. He is credited for being one of the 10 ministers who signed the Independence of Singapore Agreement in 1965.
Together with Lee Khoon Choy, Jek was appointed as the government representatives on the Joint-Government-University Liaison Committee in 1960 to reform Nanyang University.
Jek was considered as one of the 'Old Guard'—the first generation of leaders of independent Singapore.
One of his final major public appearances was at the National Day Parade of 2015 in remembrance of Lee Kuan Yew.

## Death

Jek died at home at the age of 87 on 3 June 2018. A private wake and funeral was held in accordance with his wishes. As a mark of respect, the government ordered the state flag on all government buildings to be flown at half-mast on 7 June 2018. Prime Minister Lee Hsien Loong, President Halimah Yacob and many other political figures in Singapore offered their condolences to Jek's family.
Jek was survived by his 84-year-old wife Huang Kek Chee, his two sons Kian Jin and Kian Yee (aged 59 and 55 respectively), and five grandchildren.

## Honours and awards

Jek was awarded the Second Class of the Order of Nila Utama in 1990.
# Clutton Rural District

Clutton was a rural district in Somerset, England, from 1894 to 1974.
It was created in 1894 under the Local Government Act 1894 as a successor to the rural sanitary district.
In 1974 it was abolished under the Local Government Act 1972. The parishes in the district became part of the Non-metropolitan district of Wansdyke in the newly formed County of Avon.
Avon was itself abolished in 1996 and the administration of Clutton became the responsibility of the new unitary authority of Bath and North East Somerset (BANES).
BANES took over the parishes of Cameley, Chelwood, Chew Magna, Chew Stoke, Clutton, Compton Martin, East Harptree, Farmborough, Farrington Gurney, High Littleton, Hinton Blewett, Nempnett Thrubwell, Norton Malreward, Paulton, Publow, Stanton Drew, Stowey-Sutton, Timsbury, Ubley and West Harptree.
The parishes of Chilcompton, Litton and Ston Easton became the responsibility of the Mendip Council (within Somerset County Council).
# Washington County Jail and Sheriff's Residence (Salem, Indiana)

Washington County Jail and Sheriff's Residence is a historic jail and residence located at Salem, Washington County, Indiana. It was built in 1881, and is a Second Empire style brick and stone building. It consists of a 2+1⁄2-story residence with a mansard roof with a 1+1⁄2-story rear jail addition. An office addition was added to the jail in 1974.$^{:2}$
It was listed on the National Register of Historic Places in 1984. It is included in the Salem Downtown Historic District.
# Washington Park Clubhouse

The Washington Park Clubhouse is located in Kenosha, Wisconsin.

## History

The clubhouse services a public golf course, which was opened in 1922. In part, the clubhouse was a Works Progress Administration project. The building was added to the State Register of Historic Places in 2002 and to the National Register of Historic Places the following year.
# Ren Tazawa

Ren Tazawa (田澤 廉, Tazawa Ren, born 11 November 2000) is a Japanese long-distance runner, who specializes in the 10,000 metres. He won the 10,000 metres at the 2023 Asian Athletics Championships.

## Personal bests

Outdoor
* 3000 metres – 8:27.43 (Sydney 2018)
* 5000 metres – 13:22.60 (Kumamoto 2022)
* 10,000 metres – 27:23.44 (Yokohama 2021)
# Haruka Saito

Haruka Saito (斎藤 春香, Saitō Haruka) (born March 14, 1970, in Hirosaki, Aomori, Japan) is a Japanese softball player. She played in the Hitachi softball club from 1994 to 2006 and represented Japan as part of the Japan women's national softball team in the 1996, 2000, and 2004 Olympic Games. In 2000 and 2004, she played in the teams that won the bronze and silver medals, respectively.

## Retirement

Following her final Olympics appearance in 2004, Saitō continued at Hitachi softball club as a playing coach until 2006, when she became the coach for the national team. She led them to the gold medal at the 2008 Olympics. In 2011, national teammate, Reika Utsugi, succeeded her as the national team coach.
She currently serves as the technical vice chair on the Japan Softball Association. On 26 June, she was selected as a board director on the Japanese Olympic Committee (JOC), a move that doubled the number of women directors.
# Fastenal

Fastenal Company is an American publicly traded company based in Winona, Minnesota, founded in 1967. It placed 479 in the 2021 Fortune 500 based on its 2020 revenues, and its stock is a component of the Nasdaq 100 and S&P 500 stock market indices. Fastenal had 3,334 in-market locations as of March 2023.
Fastenal refers to itself as a supply chain solutions company, while Reuters calls it an industrial distributor.

## History

Founded in 1967 by Bob Kierlin, the company was incorporated on December 24, 1968. Fastenal's offerings include both purchased and manufactured products.
In January 2016, Daniel L. Florness became the President and CEO of Fastenal. Florness started with Fastenal in 1996 as the company's chief financial officer.
Fastenal has been a sponsor of NASCAR since 2006, and in 2020, they became the official MRO partner of the NHL.
In 2009, Fastenal acquired parts of Holo-Krome, a socket head screw-making company. Fastenal then was added to the S&P 500 index in late 2008.

### Canada

It entered the Canadian market in 1994. The company has branch locations in every province and two Canadian distribution centers.

### Mexico

In 1999, Fastenal entered the market in Mexico. Fastenal has branches in 14 of Mexico's states as well as a distribution center.

### Asia

Fastenal's Asian trading company, Fastenal Asian Sourcing and Trading Co, is a Wholly Foreign-Owned Enterprise located in Shanghai, China, where it directs sourcing and import purchasing activities. Opened in 2001, Fastenal's Singapore location was its first site outside North America. By 2009, sales operations in Shanghai were complemented by those in its larger neighbor Malaysia. Locally incorporated Fastenal Malaysia Sdn Bhd is associated with Fastenal's Malaysian activities. The company runs an A2LA accredited testing laboratory in this nation as of 2014.

## Products and services

Fastenal first sold mostly fasteners such as screws, threaded rods, and nuts, which are used in construction and manufacturing. Today's product range is more diverse, and the company had a total of 690,000 individual products as of 2010. In addition to a plethora of SKUs, the company offers a variety of services, including inventory management, small fastener manufacture, vending and machining.
Fastenal has retail stores in every U.S. state, every province of Canada, 14 Mexican states, Puerto Rico and Panama.
As of 2000, the company employs 400-plus people at six manufacturing locations, including one manufacturing bolts made using a newer method, cold heading, in Rockford, Illinois; an operation in Wallingford, Connecticut, and another in Malaysia, etc.
Internationally, Fastenal has sites in China, Dominican Republic, Hungary, Malaysia, the Netherlands, Germany, Singapore and the United Kingdom. In 2006, the company had two sourcing offices in Asia, China and Taiwan. Both have an accredited testing laboratory, which, as of 2007, was A2LA certified.

## Gallery

* Fastenal in Winona