# Janelle Ayres

Janelle S. Ayres is an American immunologist and microbiologist, member of the NOMIS Center for Immunobiology and Microbial Pathogenesis and Helen McLoraine Developmental Chair at the Salk Institute for Biological Sciences. Her research focuses on the relation of host-pathogen interactions with the microbiome.

## Education

Ayres received her BA in molecular and cell biology at the University of California, Berkeley and her PhD at Stanford University School of Medicine in the laboratory of David Schneider, working on resistance and infection tolerance using the model organism Drosophila. She then completed a postdoctoral fellowship with Russell Vance at the University of California, Berkeley where she published on the role of innate immunity in the recognition of drug resistant pathobionts, or potentially virulent species from the microbiome.

## Research

Ayres current research focuses on how microbes can promote the health of their host organism. She uses mathematical and evolutionary models to predict how the beneficial microbes in the gut can be used to fight diseases. Specifically, her lab has demonstrated how a strain of E. coli prevents inflammation-induced wasting, and how a strain Salmonella inhibits sickness-induced anorexia, thus protecting their host from the deleterious effects of infection.

## Publications

* Troha, K., Ayres, J.S. Metabolic Adaptations to Infections at the Organismal Level. (2020) Trends in Immunology. DOI: 10.1016/j.it.2019.12.001
* Ayres, J.S. Immunometabolism of infections. (2019) Nature Reviews Immunology. DOI: 10.1038/s41577-019-0266-9
* McCarville, J.L., Ayres, J.S. Host-Pathogen Relationship Advice: Fat Protects against a Broken Heart. (2019) Cell Metabolism. 30(3):409-411. DOI: 10.1016/j.cmet.2019.08.007
* Wallace, M., Green, C.R., Roberts, L.S., Lee, Y.M., McCarville, J.L., Sanchez-Gurmaches, J., Meurs, N., Gengatharan, J.M., Hover, J.D., Phillips, S.A., Ciaraldi, T.P., Guertin, D.A., Cabrales, P., Ayres, J.S., Nomura, D.K., Loomba, R., Metallo, C.M. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. (2018) Nature Chemical Biology. 14(11):1021-1031. DOI: 10.1038/s41589-018-0132-2
* Sanchez, K.K., Chen, G.Y., Schieber, A.M.P., Redford, S.E., Shokhirev, M.N., Leblanc, M., Lee, Y.M., Ayres, J.S. Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen. (2018) Cell. 175(1):146-158. DOI: 10.1016/j.cell.2018.07.016
* Chen, G.Y., Ayres, J.S. When the Gut Gets Tough, the Enterocytes Get Going. (2018) Immunity. 48(5):837-839. DOI: 10.1016/j.immuni.2018.04.036
* McCarville, J.L., Ayres, J.S. Disease tolerance: concept and mechanisms. (2018) Current Opinion in Immunology. 50:88-93. DOI: 10.1016/j.coi.2017.12.003
* Lee, Y.M., Ayres, J.S. Decoding the intestinal epithelium cell by cell. (2018) Nature Immunology. 19(1):7-9. DOI: 10.1038/s41590-017-0011-0
* Rao, S., Ayres, J.S. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. (2017) Seminars in Immunology. 32:54-61. DOI: 10.1016/j.smim.2017.08.004
* Rauch, I., Deets, K.A., Ji, D.X., von Moltke, J., Tenthorey, J.L., Lee, A.Y., Philip, N.H., Ayres, J.S., Brodsky, I.E., Gronert, K., Vance, R.E. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. (2017) Immunity. 46(4):649-659. DOI: 10.1016/j.immuni.2017.03.016
* Rao, S., Schieber, A.M., O'Connor, C.P., Leblanc, M., Michel, D., Ayres, J.S. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. (2017) Cell. 168(3):503-516.e12. DOI: 10.1016/j.cell.2017.01.006
* Ayres, J.S. Microbes Dress for Success: Tolerance or Resistance? (2017) Trends in Microbiology. 25(1):1-3. DOI: 10.1016/j.tim.2016.11.006
* Schieber, A.M., Ayres, J.S. Thermoregulation as a disease tolerance defense strategy. (2016) Pathog Dis. 74(9). DOI: 10.1093/femspd/ftw106
* Ayres, J.S. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. (2016) Cell. 166(6):1368-70. DOI: 10.1016/j.cell.2016.08.034
* Ayres, J.S. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. (2016) Cell. 165(6):1323-1331. DOI: 10.1016/j.cell.2016.05.049
* Shen, R., Wang, B., Giribaldi, M.G., Ayres, J., Thomas, J.B., Montminy, M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(23):E3307-14. DOI: 10.1073/pnas.1606106113
* Schieber, A.M., Lee, Y.M., Chang, M.W., Leblanc, M., Collins, B., Downes, M., Evans, R.M., Ayres, J.S. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. (2015) Science. 350(6260):558-63. DOI: 10.1126/science.aac6468
* Ayres, J.S. Inflammasome-microbiota interplay in host physiologies. (2013) Cell Host & Microbe. 14(5):491-7. DOI: 10.1016/j.chom.2013.10.013
* Manzanillo, P.S., Ayres, J.S., Watson, R.O., Collins, A.C., Souza, G., Rae, C.S., Schneider, D.S., Nakamura, K., Shiloh, M.U., Cox, J.S. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. (2013) Nature. 501(7468):512-6. DOI: 10.1038/nature12566
* von Moltke, J., Ayres, J.S., Kofoed, E.M., Chavarría-Smith, J., Vance, R.E. Recognition of bacteria by inflammasomes. (2013) Annual Review of Immunology. 31:73-106. DOI: 10.1146/annurev-immunol-032712-095944
* Ayres, J.S., Trinidad, N.J., Vance, R.E. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. (2012) Nature Medicine. 18(5):799-806. DOI: 10.1038/nm.2729
* Ayres, J.S., Vance, R.E. Cellular teamwork in antibacterial innate immunity. (2012) Nature Immunology. 13(2):115-7. DOI: 10.1038/ni.2212

## Award and honors

* Blavatnik National Award for Young Scientists (2018)
* NIH Director's Pioneer Award (2018)
* Senior Research Award, Crohn's and Colitis Foundation of America (2016)
* DARPA Young Faculty Award (2015)
* Kavli Fellow, National Academy of Sciences (2015)
* Searle Scholars Award, Searle Scholars Program (2014)
* Career Development Award in the Biomedical Sciences, The Ray Thomas Edwards Foundation (2014)
* Howard Hughes Medical Institute (HHMI) Investigator (2024)