# List of Late Night with Seth Meyers episodes (2021)

This is the list of episodes for Late Night with Seth Meyers in 2021.

## 2021
### January

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1083A | January 4, 2021 (2021-01-04) | Amy Poehler | Burna Boy |
| A Closer Look ||||
| 1084A | January 5, 2021 (2021-01-05) | Chelsea Handler, Maika & Maritza Moulite | N/A |
| A Closer Look, R&B Singer from the 50s ||||
| 1085A | January 6, 2021 (2021-01-06) | Nicolle Wallace, Killer Mike | N/A |
| Seth acknowledges the 2021 storming of the United States Capitol at the top of the program ||||
| 1086A | January 7, 2021 (2021-01-07) | Bill Hader, Fran Lebowitz | N/A |
| A Closer Look ||||
| 1087A | January 11, 2021 (2021-01-11) | John Goodman, Amber Ruffin & Lacey Lamar | Future Islands |
| A Closer Look ||||
| 1088A | January 12, 2021 (2021-01-12) | Carey Mulligan, Leslie Jordan, Neil Gaiman | N/A |
| A Closer Look ||||
| 1089A | January 13, 2021 (2021-01-13) | Bobby Moynihan, Representative Andy Kim | N/A |
| A Closer Look ||||
| 1090A | January 14, 2021 (2021-01-14) | Anne Hathaway, Jane Levy | N/A |
| A Closer Look, Bad Sponsors ||||
| 1091A | January 18, 2021 (2021-01-18) | James Spader, Anthony Atamanuik | Julia Michaels |
| A Closer Look ||||
| 1092A | January 19, 2021 (2021-01-19) | Rachel Maddow, Billie Piper | N/A |
| A Closer Look ||||
| 1093A | January 20, 2021 (2021-01-20) | Chris Hayes | N/A |
| A Closer Look ||||
| 1094A | January 21, 2021 (2021-01-21) | Senator Bernie Sanders, Abby Phillip | N/A |
| A Closer Look, Ally Hord and Seth promote Heineken 0.0, Jokes Seth Can't Tell ||||
| 1095A | January 25, 2021 (2021-01-25) | Gillian Anderson, Kate Flannery | Bartees Strange |
| A Closer Look ||||
| 1096A | January 26, 2021 (2021-01-26) | Ted Danson, Brooks Wheelan, Ann Patchett | N/A |
| Ya Burnt ||||
| 1097A | January 27, 2021 (2021-01-27) | Stanley Tucci, Kate Berlant & Jacqueline Novak | N/A |
| A Closer Look ||||
| 1098A | January 28, 2021 (2021-01-28) | Desus & Mero, Ryan Shazier | N/A |
| A Closer Look ||||

### February

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1099A | February 1, 2021 (2021-02-01) | Post Malone, Mary Steenburgen | N/A |
| A Closer Look ||||
| 1100A | February 2, 2021 (2021-02-02) | David Duchovny, Elizabeth Olsen, Wright Thompson | N/A |
| Hey! ||||
| 1101A | February 3, 2021 (2021-02-03) | Amy Schumer, Thomas Middleditch | N/A |
| A Closer Look ||||
| 1102A | February 4, 2021 (2021-02-04) | Michelle Pfeiffer, Joe Gatto, James "Murr" Murray, Sal Vulcano & Brian "Q" Quinn | N/A |
| A Closer Look ||||
| 1103A | February 8, 2021 (2021-02-08) | Bill Burr, Justin Hartley | N/A |
| A Closer Look ||||
| 1104A | February 9, 2021 (2021-02-09) | Casey Affleck, Anthony Atamanuik | N/A |
| A Closer Look ||||
| 1105A | February 10, 2021 (2021-02-10) | Allison Janney, Representative Cori Bush | N/A |
| A Closer Look, Back in My Day ||||
| 1106A | February 11, 2021 (2021-02-11) | Will Forte, Annie Mumolo | N/A |
| A Closer Look, Jeff Wright on financial stimulus ||||
| 1107A | February 22, 2021 (2021-02-22) | Secretary Pete Buttigieg | The Hold Steady |
| A Closer Look ||||
| 1108A | February 23, 2021 (2021-02-23) | Colin Jost, Harvey Guillen | N/A |
| Seth Explains Teen Slang, Andy Samberg checks in with Colin Jost during the interview ||||
| 1109A | February 24, 2021 (2021-02-24) | Ice-T, Tracey Wigfield | N/A |
| A Closer Look ||||
| 1110A | February 25, 2021 (2021-02-25) | David Spade, Jason Mantzoukas | N/A |
| A Closer Look, Crew Poetry: An Ode to Gene (final show of cameraman Gene Kelly) ||||

### March

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1111A | March 1, 2021 (2021-03-01) | Kenan Thompson, Steven Yeun | Julien Baker |
| A Closer Look ||||
| 1112A | March 2, 2021 (2021-03-02) | Regina King, Kathryn Hahn, Chang-rae Lee | N/A |
| Amber Says What ||||
| 1113A | March 3, 2021 (2021-03-03) | Jake Tapper, Glynn Turman | N/A |
| A Closer Look ||||
| 1114A | March 4, 2021 (2021-03-04) | Ike Barinholtz, Harvey Guillen, Lilly Singh | N/A |
| A Closer Look ||||
| 1115A | March 8, 2021 (2021-03-08) | Eddie Murphy, Guy Fieri | N/A |
| Amber Ruffin recaps Meghan Markle's interview with Oprah Winfrey, A Closer Look, Guy Fieri sends Seth food from his delivery service ||||
| 1116A | March 9, 2021 (2021-03-09) | Don Johnson, Christina Hendricks | Fruit Bats |
| Amber Ruffin portrays Melania Trump ||||
| 1117A | March 10, 2021 (2021-03-10) | Bill Gates, Audra McDonald | N/A |
| A Closer Look ||||
| 1118A | March 11, 2021 (2021-03-11) | Amy Poehler, Phoebe Bridgers | N/A |
| A Closer Look ||||
| 1119A | March 15, 2021 (2021-03-15) | Jennifer Garner, Representative Jamie Raskin | Valerie June |
| Amber Ruffin recaps the Grammy Awards in one minute, A Closer Look ||||
| 1120A | March 16, 2021 (2021-03-16) | Joel McHale, Yara Shahidi, Mark Harris | N/A |
| Jokes Seth Can't Tell ||||
| 1121A | March 17, 2021 (2021-03-17) | Dr. Anthony Fauci, Diane von Furstenberg | N/A |
| A Closer Look ||||
| 1122A | March 18, 2021 (2021-03-18) | Sarah Silverman, Nico Hiraga | N/A |
| Seth acknowledges the 2021 Atlanta spa shootings and writer Karen Chee comments, A Closer Look ||||
| 1123A | March 22, 2021 (2021-03-22) | Ken Jeong, Eddie Izzard | Griff |
| A Closer Look ||||
| 1124A | March 23, 2021 (2021-03-23) | Megan Mullally & Nick Offerman, Sebastian Stan, Baratunde Thurston | N/A |
| Seth acknowledges the 2021 Boulder shooting, Ya Burnt ||||
| 1125A | March 24, 2021 (2021-03-24) | Kevin Bacon, Retta | N/A |
| A Closer Look ||||
| 1126A | March 25, 2021 (2021-03-25) | Sacha Baron Cohen, Viet Thanh Nguyen | N/A |
| A Closer Look ||||

### April

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1127A | April 12, 2021 (2021-04-12) | John Oliver, Chloé Zhao | N/A |
| A Closer Look ||||
| 1128A | April 13, 2021 (2021-04-13) | Denis Leary, Cristin Milioti, Patrick Radden Keefe | N/A |
| Amber Says What ||||
| 1129A | April 14, 2021 (2021-04-14) | Gayle King, Mary Lynn Rajskub | Anderson East |
| A Closer Look ||||
| 1130A | April 15, 2021 (2021-04-15) | Rob Lowe, Domhnall & Brian Gleeson, Emerald Fennell | N/A |
| A Closer Look ||||
| 1131A | April 19, 2021 (2021-04-19) | Catherine Zeta-Jones, Wyatt Russell | N/A |
| A Closer Look ||||
| 1132A | April 20, 2021 (2021-04-20) | Hank Azaria, Brandi Carlile, Dulcé Sloan | N/A |
| The entire crew eats weed gummies, Hey!, Dina Gusovsky comments on weddings during the pandemic ||||
| 1133A | April 21, 2021 (2021-04-21) | Christine Baranski, Melissa Villaseñor | N/A |
| A Closer Look ||||
| 1134A | April 22, 2021 (2021-04-22) | Gwen Stefani, Adam McKay | Gwen Stefani |
| A Closer Look ||||
| 1135A | April 26, 2021 (2021-04-26) | Anna Kendrick, Phil Donahue & Marlo Thomas | N/A |
| Amber Ruffin recaps the 93rd Academy Awards in one minute, A Closer Look ||||
| 1136A | April 27, 2021 (2021-04-27) | Ed Helms, Michelle Buteau, Senator Jon Tester | N/A |
| The Kind of Story We Need Right Now ||||
| 1137A | April 28, 2021 (2021-04-28) | Elisabeth Moss, Ari Melber | Moon vs. Sun |
| A Closer Look ||||
| 1138A | April 29, 2021 (2021-04-29) | Justin Theroux, Leslie Jordan | Ashnikko featuring Princess Nokia |
| A Closer Look ||||

### May

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1139A | May 3, 2021 (2021-05-03) | Michael Che, Richard Kind | N/A |
| Seth Tries to Think of Literally Anything More Pathetic, A Closer Look ||||
| 1140A | May 4, 2021 (2021-05-04) | Pete Davidson, Jodie Turner-Smith, George Saunders | N/A |
| COVID Keepers, Jodie Turner-Smith brings Seth a gift ||||
| 1141A | May 5, 2021 (2021-05-05) | Senator Amy Klobuchar, Robin Thede | Ryan Hurd featuring Maren Morris |
| A Closer Look ||||
| 1142A | May 6, 2021 (2021-05-06) | Dave Grohl, Ziwe | Foo Fighters |
| A Closer Look, Jeff Wright offers an inside look at the Derek Chauvin trial verdict ||||
| 1143A | May 10, 2021 (2021-05-10) | Tracee Ellis Ross, Paula Pell | N/A |
| Dammit, That's Really Funny, A Closer Look ||||
| 1144A | May 11, 2021 (2021-05-11) | Amy Adams, Stacey Abrams | Ashe |
| Ya Burnt ||||
| 1145A | May 12, 2021 (2021-05-12) | Aidy Bryant, Barry Jenkins | N/A |
| A Closer Look, Aidy Bryant takes questions from characters she is playing in the audience ||||
| 1146A | May 13, 2021 (2021-05-13) | Anthony Mackie, Jean Smart | N/A |
| A Closer Look ||||
| 1147A | May 17, 2021 (2021-05-17) | Julianna Margulies, Josh Duhamel | Alaina Castillo |
| A Closer Look ||||
| 1148A | May 18, 2021 (2021-05-18) | Nick Jonas, Sam Jay, Secretary Deb Haaland | N/A |
| Jokes Seth Can't Tell ||||
| 1149A | May 19, 2021 (2021-05-19) | Senator Bernie Sanders | N/A |
| A Closer Look, cue card guy Wally Feresten is interviewed when Action Bronson fails to show up ||||
| 1150A | May 20, 2021 (2021-05-20) | Rob McElhenney, Ryan O'Connell | N/A |
| A Closer Look, Leave Him Alone Guy ||||
| 1151A | May 24, 2021 (2021-05-24) | Ewan McGregor, Casey Wilson | N/A |
| A Closer Look ||||
| 1152A | May 25, 2021 (2021-05-25) | Jake Tapper, Nicole Byer, Paul W. Downs | N/A |
| New York Mayoral Candidate Ad ||||
| 1153A | May 26, 2021 (2021-05-26) | John Krasinski, Donny Deutsch | dodie |
| A Closer Look ||||
| 1154A | May 27, 2021 (2021-05-27) | Joel Edgerton, Edward-Isaac Dovere | N/A |
| A Closer Look ||||

### June

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1155A | June 7, 2021 (2021-06-07) | Patrick Wilson, Quinta Brunson | N/A |
| A Closer Look ||||
| 1156A | June 8, 2021 (2021-06-08) | Joel McHale, Bill Cowher, Carmen Christopher | N/A |
| Amber Says What ||||
| 1157A | June 9, 2021 (2021-06-09) | Will Forte, Kareem Abdul-Jabbar | N/A |
| A Closer Look ||||
| 1158A | June 10, 2021 (2021-06-10) | David Harbour, Josh O'Connor | Garbage |
| A Closer Look ||||
| 1159A | June 14, 2021 (2021-06-14) | Kenan Thompson, Juno Temple | MARINA |
| Jenny Hagel reviews In the Heights, A Closer Look ||||
| 1160A | June 15, 2021 (2021-06-15) | Wendy Williams, Paul Rabil | N/A |
| Back in My Day, Paul Rabil and Seth do a lacrosse tutorial, The Conservative Perspective/The Progressive Perspective ||||
| 1161A | June 16, 2021 (2021-06-16) | Terry Crews, Ann-Margret | N/A |
| A Closer Look, Josh Meyers portrays Gavin Newsom ||||
| 1162A | June 17, 2021 (2021-06-17) | Peyton Manning, Bowen Yang, Edgar Wright | N/A |
| A Closer Look ||||
| 1163A | June 21, 2021 (2021-06-21) | Salma Hayek, Jacqueline Novak | N/A |
| A Closer Look ||||
| 1164A | June 22, 2021 (2021-06-22) | Graham Norton, Zosia Mamet, Brandon Taylor | N/A |
| The Four New Animals, Lark Kimble: Conversation Coach ||||
| 1165A | June 23, 2021 (2021-06-23) | Bill Clinton & James Patterson, Titus Welliver | Weezer |
| A Closer Look ||||
| 1166A | June 24, 2021 (2021-06-24) | John Cena, Kristen Schaal | N/A |
| A Closer Look ||||

### July

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1167A | July 12, 2021 (2021-07-12) | Scarlett Johansson, Noah Syndergaard | N/A |
| A Closer Look ||||
| 1168A | July 13, 2021 (2021-07-13) | Amy Poehler, M. Night Shyamalan | N/A |
| Really!?! with Seth & Amy ||||
| 1169A | July 14, 2021 (2021-07-14) | Florence Pugh, Questlove | Walk the Moon |
| A Closer Look ||||
| 1170A | July 15, 2021 (2021-07-15) | Alan Cumming, Damian Lillard | N/A |
| A Closer Look ||||
| 1171A | July 19, 2021 (2021-07-19) | Shailene Woodley, Henry Winkler | N/A |
| A Closer Look ||||
| 1172A | July 20, 2021 (2021-07-20) | Kristin Chenoweth, Tim Robinson, Simon Rich | N/A |
| Ya Burnt ||||
| 1173A | July 21, 2021 (2021-07-21) | Lorde | Lorde |
| A Closer Look, Lorde and Seth go day drinking ||||
| 1174A | July 22, 2021 (2021-07-22) | Mindy Kaling, Jack Antonoff | Bleachers |
| A Closer Look ||||

### August

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1175A | August 9, 2021 (2021-08-09) | Kristen Bell & Dax Shepard, John Stamos | N/A |
| A Closer Look ||||
| 1176A | August 10, 2021 (2021-08-10) | Joseph Gordon-Levitt, Kevin Smith | N/A |
| Amy Poehler shows up during the monologue, Amber and Jenny Report on the Olympics ||||
| 1177A | August 11, 2021 (2021-08-11) | Andy Samberg, Hannah Waddingham | Tom Odell |
| A Closer Look ||||
| 1178A | August 12, 2021 (2021-08-12) | Ethan Hawke, Jodie Comer | N/A |
| Getting to Know the Lambda Variant, A Closer Look ||||
| 1179A | August 16, 2021 (2021-08-16) | Ben Platt, Dana Bash | Ben Platt |
| A Closer Look ||||
| 1180A | August 17, 2021 (2021-08-17) | Jennifer Hudson, Brendan Hunt, Lior Raz | N/A |
| Amber Says What, Dina Gusovsky talks about Britney Spears ||||
| 1181A | August 18, 2021 (2021-08-18) | Connie Britton, Ms. Pat | Sleater Kinney |
| A Closer Look, Seth's opinions on the stock market ||||
| 1182A | August 19, 2021 (2021-08-19) | Cecily Strong, Patton Oswalt | N/A |
| A Closer Look ||||
| 1183A | August 23, 2021 (2021-08-23) | Sean Penn, Sharon Horgan | N/A |
| A Closer Look ||||
| 1184A | August 24, 2021 (2021-08-24) | Melissa McCarthy & Ben Falcone, J. B. Smoove, Taylor Tomlinson | N/A |
| Back in My Day, the crew had a desk party (advertisement for Heineken) ||||
| 1185A | August 25, 2021 (2021-08-25) | Michael Keaton, Teyonah Parris | Chris Stapleton |
| A Closer Look ||||
| 1186A | August 26, 2021 (2021-08-26) | Michael Shannon, Hannah Einbinder | N/A |
| A Closer Look, Michael Shannon plays guitar ||||

### September

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1187A | September 7, 2021 (2021-09-07) | John Mulaney, Regina Hall | N/A |
| Hey!, Amber's Minute of Fury ||||
| 1188A | September 8, 2021 (2021-09-08) | Selena Gomez, Glenn Howerton | Walker Hayes |
| A Closer Look, Seth tries Selena Gomez's beauty line ||||
| 1189A | September 9, 2021 (2021-09-09) | Amanda Peet, Paula Pell | N/A |
| A Closer Look ||||
| 1190A | September 13, 2021 (2021-09-13) | Sarah Paulson, Machine Gun Kelly | N/A |
| A Closer Look ||||
| 1191A | September 14, 2021 (2021-09-14) | Kate Hudson, Jon Bernthal, Natasha Brown | N/A |
| Met Gala Outfit Names, Seth acknowledges the death of Norm Macdonald, Seth Explains Teen Slang ||||
| 1192A | September 15, 2021 (2021-09-15) | Nathan Lane, B. J. Novak | Nessa Barrett |
| A Closer Look ||||
| 1193A | September 16, 2021 (2021-09-16) | The cast of Brooklyn Nine-Nine | N/A |
| A Closer Look ||||
| 1194A | September 20, 2021 (2021-09-20) | Amy Adams, Lee Daniels | Girl in Red |
| A Closer Look ||||
| 1195A | September 21, 2021 (2021-09-21) | Bill Burr, Keith Morrison, Abby McEnany | N/A |
| A Message from California Governor Gavin Newsom (Josh Meyers portrays Newsom), Shot or Not, Keith Morrison hypes up the next night's guests ||||
| 1196A | September 22, 2021 (2021-09-22) | Secretary John Kerry, Jim Gaffigan | N/A |
| James Corden makes a special appearance at the top of the program for Climate Night, A Closer Look ||||
| 1197A | September 23, 2021 (2021-09-23) | Ike Barinholtz, Jenny Slate | N/A |
| A Closer Look ||||
| 1198A | September 27, 2021 (2021-09-27) | Billy Bob Thornton, Miriam Margolyes | N/A |
| A Closer Look ||||
| 1199A | September 28, 2021 (2021-09-28) | Ray Liotta, Natasia Demetriou, Spencer Ackerman | N/A |
| Jokes Seth Can't Tell, The Wrong Take ||||
| 1200A | September 29, 2021 (2021-09-29) | Demi Lovato, Neal Brennan | Audrey Nuna featuring Saba |
| A Closer Look ||||
| 1201A | September 30, 2021 (2021-09-30) | Colin Jost, Michael Gandolfini | N/A |
| A Closer Look ||||

### October

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1202A | October 4, 2021 (2021-10-04) | Blake Griffin, David Chase | N/A |
| A Closer Look ||||
| 1203A | October 5, 2021 (2021-10-05) | Jason Momoa & Dave Bautista, Alessandro Nivola, Anthony Doerr | N/A |
| Surprise Inspection! ||||
| 1204A | October 6, 2021 (2021-10-06) | Blake Shelton, Brett Goldstein | Cuco |
| A Closer Look ||||
| 1205A | October 7, 2021 (2021-10-07) | Jason Sudeikis, Brendan Hunt & Joe Kelly | N/A |
| A Closer Look, Jenny Hagel Visits a Lesbian Bar ||||
| 1206 | October 11, 2021 (2021-10-11) | Ron & Clint Howard, Secretary Hillary Clinton & Louise Penny | N/A |
| First show with studio audience and the 8G Band since the start of the COVID-19 pandemic, A Closer Look ||||
| 1207 | October 12, 2021 (2021-10-12) | Senator Elizabeth Warren, Matthew Macfadyen, Ricky Velez | N/A |
| Amber Ruffin comments on Donald Trump's comments on religion ||||
| 1208 | October 13, 2021 (2021-10-13) | Chris Hayes, Sarah Snook | N/A |
| A Closer Look ||||
| 1209 | October 14, 2021 (2021-10-14) | James Spader | Tate McRae |
| A Closer Look ||||
| 1210 | October 25, 2021 (2021-10-25) | Anderson Cooper, Cobie Smulders | N/A |
| A Closer Look ||||
| 1211 | October 26, 2021 (2021-10-26) | Amanda Seyfried, Rebecca Ferguson | Caroline, or Change |
| Surprise Inspection!, Amber Ruffin discusses Halloween ||||
| 1212 | October 27, 2021 (2021-10-27) | Beanie Feldstein, Norman Lear | Lady A |
| A Closer Look ||||
| 1213 | October 28, 2021 (2021-10-28) | Olivia Munn, Roy Wood Jr., Jason Blum | N/A |
| What's Actually Left in Build Back Better, A Closer Look ||||

### November

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1214 | November 1, 2021 (2021-11-01) | Tracy Morgan, Colin Quinn | N/A |
| A Closer Look ||||
| 1215 | November 2, 2021 (2021-11-02) | Willie Geist, Steve Schirripa & Michael Imperioli, Fortune Feimster | N/A |
| The Kind of Story We Need Right Now, Dina Gusovsky portrays Sheryl Sandberg ||||
| 1216 | November 3, 2021 (2021-11-03) | Keri Russell, Joe Pera | Jake Wesley Rogers |
| Animal–Themed Terms PETA Would Like to See Changed, A Closer Look ||||
| 1217 | November 4, 2021 (2021-11-04) | Kumail Nanjiani, Jonathan Majors | N/A |
| A Closer Look, Mike Scollins wants to get tickets for a Late Night with Seth Meyers taping for a friend in June ||||
| 1218 | November 8, 2021 (2021-11-08) | Pete Davidson, Emily Ratajkowski | N/A |
| A Closer Look ||||
| 1219 | November 9, 2021 (2021-11-09) | Sarah Silverman, Gary Gulman, Mark Ronson | N/A |
| Amber Says What ||||
| 1220 | November 10, 2021 (2021-11-10) | Gayle King, David Copperfield | Aurora |
| A Closer Look ||||
| 1221 | November 11, 2021 (2021-11-11) | Taylor Swift, Aisling Bea | N/A |
| A Closer Look ||||
| 1222 | November 15, 2021 (2021-11-15) | Bill Murray, Dan Aykroyd & Ernie Hudson, Ellie Kemper | N/A |
| A Closer Look ||||
| 1223 | November 16, 2021 (2021-11-16) | Aubrey Plaza, Peter Sarsgaard, Amor Towles | N/A |
| Ya Burnt, Todd Khan ||||
| 1224 | November 17, 2021 (2021-11-17) | Benedict Cumberbatch, David Arquette | Latto |
| A Closer Look ||||
| 1225 | November 18, 2021 (2021-11-18) | Paul Rudd, Jared Harris | N/A |
| A Closer Look ||||
| 1226 | November 22, 2021 (2021-11-22) | Michael Che, Representative Adam Schiff | N/A |
| A Closer Look ||||
| 1227 | November 23, 2021 (2021-11-23) | Lin-Manuel Miranda, Rachel Dratch | Mastodon |
| Back in My Day ||||
| 1228 | November 24, 2021 (2021-11-24) | Andy Samberg, Jesse Plemons | N/A |
| A Closer Look, A Farthing Look ||||
| 1229 | November 25, 2021 (2021-11-25) | The Meyers Family | N/A |
| Surprise Inspection!, Larry Meyers plugs his YouTube series ||||

### December

| No. | Original release date | Guest(s) | Musical/entertainment guest(s) |
| 1230 | December 6, 2021 (2021-12-06) | Javier Bardem, Kimberly Williams-Paisley & Ashley Williams | N/A |
| A Closer Look ||||
| 1231 | December 7, 2021 (2021-12-07) | Halle Berry, Chris Kattan, Rutger Bregman | N/A |
| Jokes Seth Can't Tell ||||
| 1232 | December 8, 2021 (2021-12-08) | Brian Cox, George Stephanopoulos | Wet Leg |
| A Closer Look ||||
| 1233 | December 9, 2021 (2021-12-09) | Tom Holland, Anna Konkle & Maya Erskine | N/A |
| A Closer Look ||||
| 1234 | December 13, 2021 (2021-12-13) | Patti LuPone, James Acaster | Joy Crookes |
| A Closer Look ||||
| 1235 | December 14, 2021 (2021-12-14) | Will Forte, David Baddiel | Father John Misty |
| Getting to Know the Omicron Variant, Seth & Will Go Day Drinking ||||
| 1236 | December 15, 2021 (2021-12-15) | Matthew McConaughey, Marisa Tomei | Turnstile |
| A Closer Look ||||
| 1237 | December 16, 2021 (2021-12-16) | Priyanka Chopra Jonas, Kyle Mooney | N/A |
| A Closer Look ||||