# 2025 Cleveland Open – Singles

Patrick Kypson was the defending champion but chose not to defend his title.
Colton Smith won the title after defeating Eliot Spizzirri 6–4, 6–7$^{(6–8)}$, 6–3 in the final.

## Seeds

* Federico Agustín Gómez (first round)
* Radu Albot (first round)
* Ethan Quinn (first round)
* James Trotter (quarterfinals)
* Brandon Holt (second round, withdrew)
* Eliot Spizzirri (final)
* Karue Sell (quarterfinals)
* J. J. Wolf (semifinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| | Tyler Zink | 4 | 3 | | | | | |
| 6 | Eliot Spizzirri | 6 | 6 | | | | | |
| 6 | Eliot Spizzirri | 6 | 6 | 6 | Eliot Spizzirri | 4 | 7$^8$ | 3 |
| | | | | | Colton Smith | 6 | 6$^6$ | 6 |
| | Colton Smith | 7$^9$ | 6 | | Colton Smith | 6 | 6$^6$ | 6 |
| 8 | J. J. Wolf | 6$^7$ | 1 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | FA Gómez | 6$^5$ | 4 | | | | | | | | | | | | | | | |
| | M Cassone | 7$^7$ | 6 | | | M Cassone | 6 | 6 | | | | | | | | | | |
| Q | Jackson Ross | 4 | 2 | | | JC Aguilar | 1 | 4 | | | | | | | | | | |
| | JC Aguilar | 6 | 6 | | | | | | | | M Cassone | 7$^7$ | 6$^1$ | 5 | | | | |
| | A Mayo | 3 | 4 | | | | | | | | T Zink | 6$^4$ | 7$^7$ | 7 | | | | |
| | T Zink | 6 | 6 | | | T Zink | w/o | | | | | | | | | | | |
| PR | K Ivanovski | 1 | 1 | | 5 | B Holt | | | | | | | | | | | | |
| 5 | B Holt | 6 | 6 | | | | | | | | | | | | | T Zink | 4 | 3 |
| 4 | J Trotter | 6 | 3 | 7$^7$ | | | | | | | | | | | 6 | E Spizzirri | 6 | 6 |
| Q | Filip Pieczonka | 3 | 6 | 6$^4$ | 4 | J Trotter | 6$^3$ | 6 | 6 | | | | | | | | | |
| Q | Nathan Ponwith | 6$^5$ | 6 | 0 | Q | T Hilderbrand | 7$^7$ | 2 | 4 | | | | | | | | | |
| Q | T Hilderbrand | 7$^7$ | 4 | 6 | | | | | | 4 | J Trotter | 7 | 3 | 6$^4$ | | | | |
| | M Mmoh | 6$^3$ | 6 | 6 | | | | | | 6 | E Spizzirri | 5 | 6 | 7$^7$ | | | | |
| Q | A Rybakov | 7$^7$ | 3 | 2 | | M Mmoh | 4 | 5 | | | | | | | | | | |
| | E Escobedo | 4 | 3 | | 6 | E Spizzirri | 6 | 7 | | | | | | | | | | |
| 6 | E Spizzirri | 6 | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | Karue Sell | 6 | 7$^7$ | | | | | | | | | | | | | | |
| | Alafia Ayeni | 3 | 6$^5$ | | 7 | K Sell | 6 | 6 | | | | | | | | | |
| | J Pinnington Jones | 1 | 4 | | | C Kingsley | 4 | 4 | | | | | | | | | |
| | C Kingsley | 6 | 6 | | | | | | | 7 | K Sell | 6$^4$ | 2 | | | | |
| | R Seggerman | 6$^8$ | 5 | | | | | | | | C Smith | 7$^7$ | 6 | | | | |
| | Stefan Dostanic | 7$^{10}$ | 7 | | | S Dostanic | 4 | 4 | | | | | | | | | |
| | C Smith | 1 | 6 | 6 | | C Smith | 6 | 6 | | | | | | | | | |
| 3 | E Quinn | 6 | 1 | 4 | | | | | | | | | | | C Smith | 7$^9$ | 6 |
| 8 | JJ Wolf | 6 | 6 | | | | | | | | | | | 8 | JJ Wolf | 6$^7$ | 1 |
| WC | J Brooksby | 2 | 4 | | 8 | JJ Wolf | 7$^{13}$ | 4 | 6 | | | | | | | | |
| WC | Antoine Ghibaudo | 6 | 6 | | WC | A Ghibaudo | 6$^{11}$ | 6 | 3 | | | | | | | | |
| Q | Tristan McCormick | 3 | 3 | | | | | | | 8 | JJ Wolf | 6 | 6 | | | | |
| | Micah Braswell | 6 | 3 | 4 | | | | | | | S Kozlov | 1 | 3 | | | | |
| | S Kozlov | 4 | 6 | 6 | | S Kozlov | 6 | 6 | | | | | | | | | |
| WC | K Bigun | 6 | 7$^9$ | | WC | K Bigun | 2 | 3 | | | | | | | | | |
| 2 | R Albot | 3 | 6$^7$ | | | | | | | | | | | | | | |