# List of Major League Baseball players (Sa–Se)

The following is a list of Major League Baseball players, retired or active.

## List of Major League Baseball players

* A
* B
* C
* D
* E
* F
* G
* H
* I
* J
* K
* L
* M
* N
* O
* P
* Q
* R
* S
* T
* U
* V
* W
* X
* Y
* Z

## Sa through Se

| Name | Debut | Final game | Position | Teams |
| Kirk Saarloos | June 18, 2002 | September 20, 2008 | Pitcher | Houston Astros, Oakland Athletics, Cincinnati Reds |
| CC Sabathia | April 8, 2001 | | Pitcher | Cleveland Indians, Milwaukee Brewers, New York Yankees |
| Erik Sabel | July 9, 1999 | July 28, 2002 | Pitcher | Arizona Diamondbacks, Detroit Tigers |
| Bret Saberhagen | April 4, 1984 | August 7, 2001 | Pitcher | Kansas City Royals, New York Mets, Colorado Rockies, Boston Red Sox |
| Alex Sabo | August 1, 1936 | August 1, 1937 | Catcher | Washington Senators |
| Chris Sabo | April 4, 1988 | September 2, 1996 | Third baseman | Cincinnati Reds, Baltimore Orioles, Chicago White Sox, St. Louis Cardinals |
| Mark Saccomanno | September 8, 2008 | | First baseman | Houston Astros |
| Frank Sacka | April 29, 1951 | September 13, 1953 | Catcher | Washington Senators |
| Brian Sackinsky | April 20, 1996 | April 24, 1996 | Pitcher | Baltimore Orioles |
| Ray Sadecki | May 19, 1960 | April 23, 1977 | Pitcher | St. Louis Cardinals, San Francisco Giants, New York Mets, Atlanta Braves, Kansas City Royals, Milwaukee Brewers |
| Mike Sadek | April 13, 1973 | June 10, 1981 | Catcher | San Francisco Giants |
| Billy Sadler | September 15, 2006 | | Pitcher | San Francisco Giants, Houston Astros |
| Carl Sadler | July 31, 2002 | May 18, 2003 | Pitcher | Cleveland Indians |
| Donnie Sadler | April 1, 1998 | May 12, 2007 | Utility player | Boston Red Sox, Cincinnati Reds, Kansas City Royals, Texas Rangers, Arizona Diamondbacks |
| Ray Sadler | May 8, 2005 | May 11, 2005 | Outfielder | Pittsburgh Pirates |
| Bob Sadowski (3B) | September 16, 1960 | September 28, 1963 | Third baseman | St. Louis Cardinals, Philadelphia Phillies, Chicago White Sox, |Los Angeles Angels |
| Bob Sadowski (P) | June 19, 1963 | July 4, 1966 | Pitcher | Milwaukee Braves, Boston Red Sox |
| Ed Sadowski | April 20, 1960 | October 2, 1966 | Catcher | Boston Red Sox, Los Angeles Angels, Atlanta Braves |
| Jim Sadowski | April 24, 1974 | May 14, 1974 | Pitcher | Pittsburgh Pirates |
| Ryan Sadowski | June 28, 2009 | | Pitcher | San Francisco Giants |
| Ted Sadowski | September 2, 1960 | July 4, 1962 | Pitcher | Washington Senators, Minnesota Twins |
| Chris Sáenz | April 24, 2004 | April 24, 2004 | Pitcher | Milwaukee Brewers |
| Olmedo Sáenz | May 28, 1994 | September 27, 2007 | First baseman | Chicago White Sox, Oakland Athletics, Los Angeles Dodgers |
| Tom Saffell | July 2, 1949 | September 25, 1955 | Outfielder | Pittsburgh Pirates, Kansas City Athletics |
| Harry Sage | April 17, 1890 | October 12, 1890 | Catcher | Toledo Maumees |
| A. J. Sager | April 4, 1994 | September 26, 1998 | Pitcher | San Diego Padres, Colorado Rockies, Detroit Tigers |
| Pony Sager | May 6, 1871 | May 30, 1871 | Utility player | Rockford Forest Citys |
| Marc Sagmoen | April 15, 1997 | September 20, 1997 | Outfielder | Texas Rangers |
| Vic Saier | May 3, 1911 | August 5, 1919 | First baseman | Chicago Cubs, Pittsburgh Pirates |
| Johnny Sain | April 24, 1942 | July 15, 1955 | Pitcher | Boston Braves, New York Yankees, Kansas City Athletics |
| Mike Saipe | June 25, 1998 | July 1, 1998 | Pitcher | Colorado Rockies |
| Takashi Saito | April 9, 2006 | | Pitcher | Los Angeles Dodgers, Boston Red Sox, Atlanta Braves, Milwaukee Brewers |
| Lenn Sakata | July 21, 1977 | June 28, 1987 | Second baseman | Milwaukee Brewers, Baltimore Orioles, Oakland Athletics, New York Yankees |
| Fernando Salas | May 28, 2010 | | Pitcher | St. Louis Cardinals |
| Juan Salas | September 5, 2006 | | Pitcher | Tampa Bay Devil Rays/Rays |
| Marino Salas | May 13, 2008 | | Pitcher | Pittsburgh Pirates |
| Mark Salas | June 19, 1984 | October 5, 1991 | Catcher | St. Louis Cardinals, Minnesota Twins, New York Yankees, Chicago White Sox, Cleveland Indians, Detroit Tigers |
| Ángel Salazar | August 10, 1983 | October 1, 1988 | Shortstop | Montreal Expos, Kansas City Royals, Chicago Cubs |
| Jeff Salazar | September 7, 2006 | | Outfielder | Colorado Rockies, Arizona Diamondbacks, Pittsburgh Pirates |
| Luis Salazar | August 15, 1980 | October 4, 1992 | Third baseman | San Diego Padres, Chicago White Sox, Detroit Tigers, Chicago Cubs |
| Oscar Salazar | April 10, 2002 | | Utility infielder | Detroit Tigers, Baltimore Orioles, San Diego Padres |
| Chris Sale | August 6, 2010 | | Pitcher | Chicago White Sox |
| Freddy Sale | June 30, 1924 | June 30, 1924 | Pitcher | Pittsburgh Pirates |
| Ed Sales | July 15, 1890 | October 3, 1890 | Shortstop | Pittsburgh Alleghenys |
| Solly Salisbury | April 19, 1902 | April 24, 1902 | Pitcher | Philadelphia Phillies |
| Harry Salisbury | August 28, 1879 | September 22, 1882 | Pitcher | Troy Trojans, Pittsburgh Alleghenys |
| Bill Salkeld | April 18, 1945 | April 21, 1950 | Catcher | Pittsburgh Pirates, Boston Braves, Chicago White Sox |
| Roger Salkeld | September 8, 1993 | September 28, 1996 | Pitcher | Seattle Mariners, Cincinnati Reds |
| Slim Sallee | April 16, 1908 | September 20, 1921 | Pitcher | St. Louis Cardinals, New York Giants, Cincinnati Reds |
| Brad Salmon | May 1, 2007 | | Pitcher | Cincinnati Reds |
| Chico Salmon | June 28, 1964 | August 14, 1972 | Utility player | Cleveland Indians, Baltimore Orioles |
| Roger Salmon | May 3, 1912 | October 1, 1912 | Pitcher | Philadelphia Athletics |
| Tim Salmon | August 21, 1992 | October 1, 2006 | Outfielder | California/Anaheim Angels, Los Angeles Angels of Anaheim |
| Ángel Salomé | September 3, 2008 | | Pinch hitter | Milwaukee Brewers |
| Jarrod Saltalamacchia | May 2, 2007 | | Catcher | Atlanta Braves, Texas Rangers, Boston Red Sox |
| Jack Saltzgaver | April 12, 1932 | September 30, 1945 | Third baseman | New York Yankees, Pittsburgh Pirates |
| Gus Salve | September 14, 1908 | September 14, 1908 | Pitcher | Philadelphia Athletics |
| Jack Salveson | June 3, 1933 | September 16, 1945 | Pitcher | New York Giants, Pittsburgh Pirates, Chicago White Sox, Cleveland Indians |
| Manny Salvo | April 22, 1939 | October 3, 1943 | Pitcher | New York Giants, Boston Bees/Braves, Philadelphia Phillies |
| Jeff Samardzija | July 25, 2008 | | Pitcher | Chicago Cubs |
| Joe Sambito | July 20, 1976 | October 3, 1987 | Pitcher | Houston Astros, New York Mets, Boston Red Sox |
| Ed Samcoff | April 21, 1951 | April 26, 1951 | Second baseman | Philadelphia Athletics |
| Ron Samford | April 15, 1954 | September 23, 1959 | Shortstop | New York Giants, Detroit Tigers, Washington Senators |
| Clint Sammons | September 12, 2007 | | Catcher | Atlanta Braves |
| Bill Sampen | April 10, 1990 | May 9, 1994 | Pitcher | Montreal Expos, Kansas City Royals, California Angels |
| Billy Sample | September 2, 1978 | October 5, 1986 | Outfielder | Texas Rangers, New York Yankees, Atlanta Braves |
| Benj Sampson | September 9, 1998 | August 19, 1999 | Pitcher | Minnesota Twins |
| Chris Sampson | June 2, 2006 | | Pitcher | Houston Astros |
| Amado Samuel | April 10, 1962 | July 11, 1964 | Shortstop | Milwaukee Braves, New York Mets |
| Juan Samuel | August 24, 1983 | September 26, 1998 | Second baseman | Philadelphia Phillies, New York Mets, Los Angeles Dodgers, Kansas City Royals, Cincinnati Reds, Detroit Tigers, Toronto Blue Jays |
| Ike Samuels | August 3, 1895 | September 28, 1895 | Third baseman | St. Louis Cardinals |
| Joe Samuels | April 23, 1930 | May 1, 1930 | Pitcher | Detroit Tigers |
| Roger Samuels | July 20, 1988 | June 8, 1989 | Pitcher | San Francisco Giants, Pittsburgh Pirates |
| Alex Sanabia | June 24, 2010 | | Pitcher | Florida Marlins |
| Brian Sanches | June 1, 2006 | | Pitcher | Philadelphia Phillies, Washington Nationals, Florida Marlins |
| Alejandro Sánchez | September 6, 1982 | May 16, 1987 | Outfielder | Philadelphia Phillies, San Francisco Giants, Detroit Tigers, Minnesota Twins, Oakland Athletics |
| Alex Sanchez (P) | May 23, 1989 | June 10, 1989 | Pitcher | Toronto Blue Jays |
| Alex Sánchez (OF) | June 15, 2001 | July 23, 2005 | Outfielder | Milwaukee Brewers, Detroit Tigers, Tampa Bay Devil Rays, San Francisco Giants |
| Ángel Sánchez | September 23, 2006 | | Utility infielder | Kansas City Royals, Boston Red Sox, Houston Astros |
| Aníbal Sánchez | June 25, 2006 | | Pitcher | Florida Marlins |
| Celerino Sánchez | June 13, 1972 | September 30, 1973 | Third baseman | New York Yankees |
| Duaner Sánchez | June 14, 2002 | | Pitcher | Arizona Diamondbacks, Pittsburgh Pirates, Los Angeles Dodgers, New York Mets, San Diego Padres |
| Eduardo Sánchez | April 13, 2011 | | Pitcher | St. Louis Cardinals |
| Félix Sánchez | September 3, 2003 | September 20, 2003 | Pitcher | Chicago Cubs |
| Freddy Sanchez | September 10, 2002 | | Second baseman | Boston Red Sox, Pittsburgh Pirates, San Francisco Giants |
| Gaby Sánchez | September 17, 2008 | | First baseman | Florida Marlins |
| Héctor Sánchez | July 15, 2011 | | Catcher | San Francisco Giants |
| Humberto Sánchez | September 18, 2008 | | Pitcher | New York Yankees |
| Israel Sánchez | July 7, 1988 | October 2, 1990 | Pitcher | Kansas City Royals |
| Jesús Sánchez | March 31, 1998 | July 15, 2004 | Pitcher | Florida Marlins, Chicago Cubs, Colorado Rockies, Cincinnati Reds |
| Jonathan Sánchez | May 28, 2006 | | Pitcher | San Francisco Giants |
| Luis Sánchez | April 10, 1981 | October 6, 1985 | Pitcher | California Angels |
| Orlando Sánchez | May 6, 1981 | May 25, 1984 | Catcher | St. Louis Cardinals, Kansas City Royals, Baltimore Orioles |
| Raúl Sánchez | April 17, 1952 | May 17, 1960 | Pitcher | Washington Senators, Cincinnati Reds |
| Rey Sánchez | September 8, 1991 | June 8, 2005 | Shortstop | Chicago Cubs, New York Yankees, San Francisco Giants, Kansas City Royals, Atlanta Braves, Boston Red Sox, New York Mets, Seattle Mariners, Tampa Bay Devil Rays |
| Rómulo Sánchez | August 26, 2007 | | Pitcher | Pittsburgh Pirates, New York Yankees |
| Heinie Sand | April 17, 1923 | September 30, 1928 | Shortstop | Philadelphia Phillies |
| Gus Sandberg | May 11, 1923 | August 8, 1924 | Catcher | Cincinnati Reds |
| Jared Sandberg | August 7, 2003 | September 26, 2003 | Third baseman | Tampa Bay Devil Rays |
| Ryne Sandberg β | September 2, 1981 | September 28, 1997 | Second baseman | Philadelphia Phillies, Chicago Cubs |
| Anthony Sanders | April 26, 1999 | April 18, 2001 | Outfielder | Toronto Blue Jays, Seattle Mariners |
| Ben Sanders | June 6, 1888 | October 14, 1892 | Pitcher | Philadelphia Quakers (NL), Philadelphia Quakers (PL), Philadelphia Athletics (1891 AA), Louisville Colonels |
| David Sanders | April 23, 2003 | September 10, 2005 | Pitcher | Chicago White Sox |
| Dee Sanders | August 12, 1945 | August 13, 1945 | Pitcher | St. Louis Browns |
| Deion Sanders | May 31, 1989 | June 14, 2001 | Outfielder | New York Yankees, Atlanta Braves, Cincinnati Reds, San Francisco Giants |
| John Sanders | April 13, 1965 | April 13, 1965 | Pinch runner | Kansas City Athletics |
| Ken Sanders | August 6, 1964 | September 27, 1976 | Pitcher | Kansas City Athletics, Boston Red Sox, Oakland Athletics, Milwaukee Brewers, Minnesota Twins, Cleveland Indians, California Angels, New York Mets, Kansas City Royals |
| Ray Sanders | April 14, 1942 | September 21, 1949 | First baseman | St. Louis Cardinals, Boston Braves |
| Reggie Sanders (1B) | September 1, 1974 | October 2, 1974 | First baseman | Detroit Tigers |
| Reggie Sanders (OF) | August 22, 1991 | July 29, 2007 | Outfielder | Cincinnati Reds, San Diego Padres, Atlanta Braves, Arizona Diamondbacks, San Francisco Giants, Pittsburgh Pirates, St. Louis Cardinals, Kansas City Royals |
| Roy Sanders (NL P) | April 16, 1917 | August 27, 1918 | Pitcher | Cincinnati Reds, Pittsburgh Pirates |
| Roy Sanders (AL P) | August 6, 1918 | May 31, 1920 | Pitcher | New York Yankees, St. Louis Browns |
| Scott Sanders | August 6, 1993 | October 3, 1999 | Pitcher | San Diego Padres, Seattle Mariners, Detroit Tigers, Chicago Cubs |
| War Sanders | April 18, 1903 | July 4, 1904 | Pitcher | St. Louis Cardinals |
| Scott Sanderson | August 6, 1978 | May 15, 1996 | Pitcher | Montreal Expos, Chicago Cubs, Oakland Athletics, New York Yankees, California Angels, San Francisco Giants, Chicago White Sox |
| Mike Sandlock | September 19, 1942 | September 27, 1953 | Catcher | Boston Braves, Brooklyn Dodgers, Pittsburgh Pirates |
| Danny Sandoval | July 17, 2005 | October 1, 2006 | Utility infielder | Philadelphia Phillies |
| Freddy Sandoval | September 8, 2008 | | Utility infielder | Los Angeles Angels of Anaheim |
| Pablo Sandoval | August 14, 2008 | | Utility player | San Francisco Giants |
| Charlie Sands | June 21, 1967 | May 8, 1975 | Designated hitter | New York Yankees, Pittsburgh Pirates, California Angels, Oakland Athletics |
| Jerry Sands | April 18, 2011 | | Outfielder | Los Angeles Dodgers |
| Tommy Sandt | June 29, 1975 | October 3, 1976 | Shortstop | Oakland Athletics |
| Chance Sanford | April 30, 1998 | June 9, 1999 | Utility infielder | Pittsburgh Pirates, Los Angeles Dodgers |
| Fred Sanford | May 5, 1943 | September 14, 1951 | Pitcher | St. Louis Browns, New York Yankees, Washington Senators |
| Jack Sanford (1B) | August 24, 1940 | May 9, 1946 | First baseman | Washington Senators |
| Jack Sanford (P) | September 16, 1956 | August 6, 1967 | Pitcher | Philadelphia Phillies, San Francisco Giants, California Angels, Kansas City Royals |
| Mo Sanford | August 9, 1991 | June 6, 1995 | Pitcher | Cincinnati Reds, Colorado Rockies, Minnesota Twins |
| Manny Sanguillén | July 23, 1967 | October 5, 1980 | Catcher | Pittsburgh Pirates, Oakland Athletics |
| Ed Sanicki | September 14, 1949 | May 12, 1951 | Outfielder | Philadelphia Phillies |
| Amauri Sanit | May 12, 2011 | | Pitcher | New York Yankees |
| Ben Sankey | October 5, 1929 | September 27, 1931 | Shortstop | Pittsburgh Pirates |
| Andrés Santana | September 16, 1990 | October 3, 1990 | Shortstop | San Francisco Giants |
| Carlos Santana | June 11, 2010 | | Catcher | Cleveland Indians |
| Ervin Santana | May 17, 2005 | | Pitcher | Los Angeles Angels of Anaheim |
| Johan Santana | April 3, 2000 | | Pitcher | Minnesota Twins, New York Mets |
| Julio Santana | April 6, 1997 | May 12, 2006 | Pitcher | Texas Rangers, Tampa Bay Devil Rays, Montreal Expos, Detroit Tigers, Milwaukee Brewers, Philadelphia Phillies |
| Marino Santana | September 4, 1998 | July 23, 1999 | Pitcher | Detroit Tigers, Boston Red Sox |
| Pedro Santana | July 16, 2001 | July 16, 2001 | Second baseman | Detroit Tigers |
| Rafael Santana | April 5, 1983 | April 23, 1990 | Shortstop | St. Louis Cardinals, New York Mets, New York Yankees, Cleveland Indians |
| F. P. Santangelo | August 2, 1995 | October 7, 2001 | Outfielder | Montreal Expos, San Francisco Giants, Los Angeles Dodgers, Oakland Athletics |
| Benito Santiago | September 14, 1986 | April 11, 2005 | Catcher | San Diego Padres, Florida Marlins, Cincinnati Reds, Philadelphia Phillies, Toronto Blue Jays, Chicago Cubs, San Francisco Giants, Kansas City Royals, Pittsburgh Pirates |
| Hector Santiago | July 6, 2011 | | Pitcher | Chicago White Sox |
| José Santiago (1950s P) | April 17, 1954 | July 15, 1956 | Pitcher | Cleveland Indians, Kansas City Athletics |
| José Santiago (1960s P) | September 9, 1963 | July 6, 1970 | Pitcher | Kansas City Athletics, Boston Red Sox |
| José Santiago (2000s P) | June 7, 1997 | August 9, 2005 | Pitcher | Kansas City Royals, Philadelphia Phillies, Cleveland Indians, New York Mets |
| Ramón Santiago | May 17, 2002 | | Shortstop | Detroit Tigers, Seattle Mariners |
| Ron Santo | June 26, 1960 | September 29, 1974 | Third baseman | Chicago Cubs, Chicago White Sox |
| Rafael Santo Domingo | September 7, 1979 | September 30, 1979 | Pinch hitter | Cincinnati Reds |
| Al Santorini | September 10, 1968 | May 5, 1973 | Pitcher | Atlanta Braves, San Diego Padres, St. Louis Cardinals |
| Ángel Santos | September 8, 2001 | September 28, 2003 | Second baseman | Boston Red Sox, Cleveland Indians |
| Chad Santos | July 16, 2006 | July 20, 2006 | First baseman | San Francisco Giants |
| Francisco Santos | June 18, 2003 | July 3, 2003 | Outfielder | San Francisco Giants |
| Omir Santos | September 5, 2008 | | Catcher | Baltimore Orioles, New York Mets, Detroit Tigers |
| Sergio Santos | April 8, 2010 | | Pitcher | Chicago White Sox |
| Víctor Santos | April 9, 2001 | | Pitcher | Detroit Tigers, Colorado Rockies, Texas Rangers, Milwaukee Brewers, Pittsburgh Pirates, Cincinnati Reds, Baltimore Orioles |
| Nelson Santovenia | September 16, 1987 | October 2, 1993 | Catcher | Montreal Expos, Chicago White Sox, Kansas City Royals |
| Edward Santry | August 7, 1884 | August 12, 1884 | Shortstop | Detroit Tigers |
| Dave Sappelt | August 7, 2011 | | Outfielder | Cincinnati Reds |
| Bronson Sardinha | September 15, 2007 | | Outfielder | New York Yankees |
| Dane Sardinha | September 6, 2003 | | Catcher | Cincinnati Reds, Detroit Tigers |
| Dennis Sarfate | September 3, 2006 | | Pitcher | Milwaukee Brewers, Houston Astros, Baltimore Orioles |
| Joe Sargent | April 27, 1921 | September 25, 1921 | Utility infielder | Detroit Tigers |
| Manny Sarmiento | July 30, 1976 | October 1, 1983 | Pitcher | Cincinnati Reds, Seattle Mariners, Pittsburgh Pirates |
| Bill Sarni | May 9, 1951 | September 18, 1956 | Catcher | St. Louis Cardinals, New York Giants |
| Kazuhiro Sasaki | April 5, 2000 | September 28, 2003 | Pitcher | Seattle Mariners |
| Mackey Sasser | July 17, 1987 | May 15, 1995 | Catcher | San Francisco Giants, Pittsburgh Pirates, New York Mets, Seattle Mariners |
| Rob Sasser | July 31, 1998 | July 31, 1998 | Pinch hitter | Texas Rangers |
| Josh Satin | September 4, 2011 | | Infielder | New York Mets |
| Tom Satriano | July 23, 1961 | September 19, 1970 | Catcher | Los Angeles/California Angels, Boston Red Sox |
| Luis Saturria | September 11, 2000 | October 5, 2001 | Outfielder | St. Louis Cardinals |
| Frank Saucier | July 21, 1951 | September 23, 1951 | Outfielder | St. Louis Browns |
| Kevin Saucier | October 1, 1978 | July 25, 1982 | Pitcher | Philadelphia Phillies, Detroit Tigers |
| Ed Sauer | September 17, 1943 | October 2, 1949 | Outfielder | Chicago Cubs, St. Louis Cardinals, Boston Braves |
| Hank Sauer | September 9, 1941 | August 17, 1959 | Outfielder | Cincinnati Reds, Chicago Cubs, St. Louis Cardinals, New York/San Francisco Giants |
| Scott Sauerbeck | April 5, 1999 | September 23, 2006 | Pitcher | Pittsburgh Pirates, Boston Red Sox, Cleveland Indians, Oakland Athletics |
| Dennis Saunders | May 21, 1970 | June 12, 1970 | Pitcher | Detroit Tigers |
| Doug Saunders | June 13, 1993 | October 3, 1993 | Second baseman | New York Mets |
| Joe Saunders | August 16, 2005 | | Outfielder | Seattle Mariners, Arizona Diamondbacks |
| Michael Saunders | July 25, 2009 | | Pitcher | Los Angeles Angels of Anaheim |
| Rusty Saunders | September 24, 1927 | October 2, 1927 | Outfielder | Philadelphia Athletics |
| Tony Saunders | April 5, 1997 | May 26, 1999 | Pitcher | Florida Marlins, Tampa Bay Devil Rays |
| Al Sauter | September 8, 1890 | October 11, 1890 | Third baseman | Philadelphia Athletics |
| Rich Sauveur | July 1, 1986 | June 18, 2000 | Pitcher | Pittsburgh Pirates, Montreal Expos, New York Mets, Kansas City Royals, Chicago White Sox, Oakland Athletics |
| Bob Savage | June 24, 1942 | May 4, 1949 | Pitcher | Philadelphia Athletics, St. Louis Browns |
| Don Savage | April 18, 1944 | September 23, 1945 | Third baseman | New York Yankees |
| Jack Savage | September 14, 1987 | September 14, 1990 | Pitcher | Los Angeles Dodgers, Minnesota Twins |
| Jimmie Savage | September 3, 1912 | October 3, 1915 | Outfielder | Philadelphia Phillies, Pittsburgh Rebels |
| Ted Savage | April 9, 1962 | July 3, 1971 | Outfielder | Philadelphia Phillies, Pittsburgh Pirates, St. Louis Cardinals, Chicago Cubs, Los Angeles Dodgers, Cincinnati Reds, Milwaukee Brewers, Kansas City Royals |
| Bob Saverine | September 12, 1959 | October 1, 1967 | Second baseman | Baltimore Orioles, Washington Senators (1961–1971) |
| Joe Savery | September 20, 2011 | | Pitcher | Philadelphia Phillies |
| Don Savidge | August 6, 1929 | August 31, 1929 | Pitcher | Washington Senators |
| Ralph Savidge | September 22, 1908 | May 19, 1909 | Pitcher | Cincinnati Reds |
| Moe Savransky | April 23, 1954 | September 5, 1954 | Pitcher | Cincinnati Redlegs |
| Carl Sawatski | September 29, 1948 | September 29, 1963 | Catcher | Chicago Cubs, Chicago White Sox, Milwaukee Braves, Philadelphia Phillies, St. Louis Cardinals |
| Carl Sawyer | September 11, 1915 | October 4, 1916 | Utility infielder | Washington Senators |
| Rick Sawyer | April 28, 1974 | September 23, 1977 | Pitcher | New York Yankees, San Diego Padres |
| Will Sawyer | July 21, 1883 | September 29, 1883 | Pitcher | Cleveland Blues (NL) |
| Dave Sax | September 1, 1982 | April 26, 1987 | Catcher | Los Angeles Dodgers, Boston Red Sox |
| Ollie Sax | April 13, 1928 | September 30, 1928 | Third baseman | St. Louis Browns |
| Steve Sax | August 18, 1981 | May 8, 1994 | Second baseman | Los Angeles Dodgers, New York Yankees, Chicago White Sox, Oakland Athletics |
| Jimmy Say | July 22, 1882 | September 6, 1887 | Third baseman | Louisville Eclipse, Philadelphia Athletics (AA), Wilmington Quicksteps, Kansas City Cowboys (UA), Cleveland Blues |
| Lou Say | April 14, 1873 | October 19, 1884 | Shortstop | Baltimore Marylands, Baltimore Canaries, Washington Nationals (NA), Cincinnati Reds (1876–1880), Philadelphia Athletics (AA), Baltimore Orioles (19th century), Baltimore Monumentals, Kansas City Cowboys (UA) |
| Bill Sayles | July 17, 1939 | August 28, 1943 | Pitcher | Boston Red Sox, New York Giants, Brooklyn Dodgers |
| Phil Saylor | July 11, 1891 | July 11, 1891 | Pitcher | Philadelphia Phillies |
| Jay Sborz | June 22, 2010 | | Pitcher | Detroit Tigers |
| Jerry Scala | April 22, 1948 | September 26, 1950 | Outfielder | Chicago White Sox |
| Bobby Scales | May 5, 2009 | | Outfielder | Chicago Cubs |
| Johnny Scalzi | June 19, 1931 | June 24, 1931 | Pinch hitter | Boston Braves |
| Skeeter Scalzi | July 21, 1939 | September 25, 1939 | Shortstop | New York Giants |
| Bob Scanlan | May 7, 1991 | September 29, 2001 | Pitcher | Chicago Cubs, Milwaukee Brewers, Detroit Tigers, Kansas City Royals, Houston Astros, Montreal Expos |
| Doc Scanlan | September 24, 1903 | September 1, 1911 | Pitcher | Pittsburgh Pirates, Brooklyn Superbas/Dodgers |
| Frank Scanlan | August 6, 1909 | September 1, 1909 | Pitcher | Philadelphia Phillies |
| Mort Scanlan | April 21, 1890 | April 23, 1890 | First baseman | New York Giants |
| Pat Scanlon (OF) | July 4, 1884 | July 11, 1884 | Outfielder | Boston Reds (UA) |
| Pat Scanlon (3B) | September 27, 1974 | October 2, 1977 | Third baseman | Montreal Expos, San Diego Padres |
| Pat Scantlebury | April 19, 1956 | August 3, 1956 | Pitcher | Cincinnati Reds |
| Randy Scarbery | April 16, 1979 | May 29, 1980 | Pitcher | Chicago White Sox |
| Ray Scarborough | June 26, 1942 | September 25, 1953 | Pitcher | Washington Senators, Chicago White Sox, Boston Red Sox, New York Yankees, Detroit Tigers |
| Mac Scarce | July 10, 1972 | June 25, 1978 | Pitcher | Philadelphia Phillies, New York Mets, Minnesota Twins |
| Russ Scarritt | April 18, 1929 | May 25, 1932 | Outfielder | Boston Red Sox, Philadelphia Phillies |
| Les Scarsella | September 15, 1935 | May 19, 1940 | First baseman | Cincinnati Reds, Boston Braves |
| Steve Scarsone | May 15, 1992 | September 8, 1999 | Utility infielder | Philadelphia Phillies, Baltimore Orioles, San Francisco Giants, St. Louis Cardinals, Kansas City Royals |
| Paul Schaal | September 3, 1964 | July 19, 1974 | Third baseman | Los Angeles/California Angels, Kansas City Royals |
| Al Schacht | September 18, 1919 | September 6, 1921 | Pitcher | Washington Senators |
| Sid Schacht | April 23, 1950 | June 26, 1951 | Pitcher | St. Louis Browns, Boston Braves |
| Hal Schacker | May 9, 1945 | June 14, 1945 | Pitcher | Boston Braves |
| Germany Schaefer | October 5, 1901 | April 25, 1918 | Second baseman | Chicago Orphans, Detroit Tigers, Washington Senators, Newark Peppers, New York Yankees, Cleveland Indians |
| Jeff Schaefer | April 7, 1989 | June 15, 1994 | Utility infielder | Chicago White Sox, Seattle Mariners, Oakland Athletics |
| Harry Schaeffer | July 28, 1952 | August 20, 1952 | Pitcher | New York Yankees |
| Mark Schaeffer | April 18, 1972 | September 26, 1972 | Pitcher | San Diego Padres |
| Harry Schafer | May 5, 1871 | August 31, 1878 | Third baseman | Boston Red Stockings/Red Caps |
| Jordan Schafer | April 5, 2009 | | Outfielder | Atlanta Braves, Houston Astros |
| Logan Schafer | September 2, 2011 | | Outfielder | Milwaukee Brewers |
| Jimmie Schaffer | May 20, 1961 | July 11, 1968 | Catcher | St. Louis Cardinals, Chicago Cubs, Chicago White Sox, New York Mets, Philadelphia Phillies, Cincinnati Reds |
| Joe Schaffernoth | April 15, 1959 | September 30, 1961 | Pitcher | Chicago Cubs, Cleveland Indians |
| Johnny Schaive | September 19, 1958 | April 19, 1963 | Utility infielder | Washington Senators, Washington Senators (1961–1971) |
| Ray Schalk β | April 11, 1912 | September 15, 1929 | Catcher | Chicago White Sox, New York Giants |
| Roy Schalk | September 17, 1932 | September 9, 1945 | Second baseman | Chicago White Sox |
| Gene Schall | June 16, 1995 | September 29, 1996 | First baseman | Philadelphia Phillies |
| Biff Schaller | April 30, 1911 | July 21, 1913 | Outfielder | Detroit Tigers, Chicago White Sox |
| Art Schallock | July 16, 1951 | September 23, 1955 | Pitcher | New York Yankees, Baltimore Orioles |
| Bobby Schang | September 23, 1914 | May 28, 1927 | Catcher | Pittsburgh Pirates, New York Giants, St. Louis Cardinals |
| Wally Schang | May 9, 1913 | June 22, 1931 | Catcher | Philadelphia Athletics, Boston Red Sox, New York Yankees, St. Louis Browns, Detroit Tigers |
| Charley Schanz | April 20, 1944 | July 2, 1950 | Pitcher | Philadelphia Blue Jays/Phillies, Boston Red Sox |
| John Schappert | May 3, 1882 | July 4, 1882 | Pitcher | St. Louis Brown Stockings (AA) |
| Bill Schardt | April 14, 1911 | May 18, 1912 | Pitcher | Brooklyn Dodgers |
| Art Scharein | July 6, 1932 | June 3, 1934 | Third baseman | St. Louis Browns |
| George Scharein | April 19, 1937 | April 28, 1940 | Shortstop | Philadelphia Phillies |
| Nick Scharf | May 18, 1882 | June 11, 1883 | Outfielder | Baltimore Orioles (19th century) |
| Jeff Schattinger | September 21, 1981 | September 21, 1981 | Pitcher | Kansas City Royals |
| Dan Schatzeder | September 4, 1977 | May 25, 1991 | Pitcher | Montreal Expos, Detroit Tigers, New York Giants, Philadelphia Phillies, Minnesota Twins, Cleveland Indians, Houston Astros, New York Mets, Kansas City Royals |
| Rube Schauer | August 27, 1913 | September 29, 1917 | Pitcher | New York Giants, Philadelphia Athletics |
| Al Scheer | August 2, 1913 | October 3, 1915 | Outfielder | Brooklyn Superbas, Indianapolis Hoosiers (FL), Newark Peppers |
| Heinie Scheer | April 20, 1922 | September 26, 1923 | Second baseman | Philadelphia Athletics |
| Fritz Scheeren | September 14, 1914 | May 11, 1915 | Outfielder | Pittsburgh Pirates |
| Owen Scheetz | April 22, 1943 | May 9, 1943 | Pitcher | Washington Senators |
| Aaron Scheffer | June 13, 1999 | June 20, 1999 | Pitcher | Seattle Mariners |
| Bob Scheffing | April 27, 1941 | September 11, 1951 | Catcher | Chicago Cubs, Cincinnati Reds, St. Louis Cardinals |
| Ted Scheffler | August 7, 1888 | October 15, 1890 | Outfielder | Detroit Wolverines, Rochester Broncos |
| Lefty Schegg | August 20, 1912 | August 27, 1912 | Pitcher | Washington Senators |
| Carl Scheib | September 6, 1943 | May 24, 1954 | Pitcher | Philadelphia Athletics, St. Louis Cardinals |
| Frank Scheibeck | May 9, 1887 | September 13, 1906 | Shortstop | Cleveland Blues (AA), Detroit Wolverines, Toledo Maumees, Pittsburgh Pirates, Washington Senators (1891–99), Cleveland Blues (AL), Detroit Tigers |
| Jack Scheible | September 8, 1893 | September 20, 1894 | Pitcher | Cleveland Spiders, Philadelphia Phillies |
| Rich Scheid | September 11, 1992 | May 12, 1995 | Pitcher | Houston Astros, Florida Marlins |
| Richie Scheinblum | September 1, 1965 | September 21, 1974 | Outfielder | Cleveland Indians, Washington Senators (1961–1971), Kansas City Royals, Cincinnati Reds, California Angels, St. Louis Cardinals |
| Danny Schell | April 13, 1954 | April 22, 1955 | Outfielder | Philadelphia Phillies |
| Jim Schelle | July 23, 1939 | July 23, 1939 | Pitcher | Philadelphia Athletics |
| Al Schellhase | May 7, 1890 | October 4, 1891 | Catcher | Boston Beaneaters, Louisville Colonels |
| Fred Schemanske | September 15, 1923 | October 3, 1923 | Pitcher | Washington Senators |
| Mike Schemer | August 8, 1945 | April 24, 1946 | First baseman | New York Giants |
| Bill Schenck | May 29, 1882 | September 7, 1885 | Utility infielder | Louisville Eclipse, Richmond Virginians, Brooklyn Grays |
| John Scheneberg | September 23, 1913 | September 24, 1920 | Pitcher | Pittsburgh Pirates, St. Louis Browns |
| Hank Schenz | September 18, 1946 | September 13, 1951 | Second baseman | Chicago Cubs, Pittsburgh Pirates, New York Giants |
| Joe Schepner | September 11, 1919 | September 28, 1919 | Third baseman | St. Louis Browns |
| Bob Scherbarth | April 23, 1950 | April 23, 1950 | Catcher | Boston Red Sox |
| Harry Scherer | July 24, 1889 | July 24, 1889 | Outfielder | Louisville Colonels |
| Fred Scherman | April 26, 1969 | July 6, 1976 | Pitcher | Detroit Tigers, Houston Astros, Montreal Expos |
| Bill Scherrer | September 7, 1982 | July 28, 1988 | Pitcher | Cincinnati Reds, Detroit Tigers, Baltimore Orioles, Philadelphia Phillies |
| Max Scherzer | April 29, 2008 | | Pitcher | Arizona Diamondbacks, Detroit Tigers |
| Dutch Schesler | April 16, 1931 | August 12, 1931 | Pitcher | Philadelphia Phillies |
| Lou Schettler | April 25, 1910 | October 1, 1910 | Pitcher | Philadelphia Phillies |
| Lou Schiappacasse | September 7, 1902 | September 8, 1902 | Outfielder | Detroit Tigers |
| Morrie Schick | April 15, 1917 | September 29, 1917 | Outfielder | Chicago Cubs |
| Nate Schierholtz | June 11, 2007 | | Outfielder | San Francisco Giants |
| Chuck Schilling | April 11, 1961 | October 3, 1965 | Second baseman | Boston Red Sox |
| Curt Schilling | September 7, 1988 | September 25, 2007 | Pitcher | Baltimore Orioles, Houston Astros, Philadelphia Phillies, Arizona Diamondbacks, Boston Red Sox |
| Red Schillings | September 11, 1922 | September 28, 1922 | Pitcher | Philadelphia Athletics |
| Bill Schindler | September 3, 1920 | September 3, 1920 | Catcher | St. Louis Cardinals |
| Calvin Schiraldi | September 1, 1984 | July 3, 1991 | Pitcher | New York Mets, Boston Red Sox, Chicago Cubs, San Diego Padres, Texas Rangers |
| Dutch Schirick | September 17, 1914 | September 17, 1914 | Pinch hitter | St. Louis Browns |
| Larry Schlafly | September 18, 1902 | October 10, 1914 | Second baseman | Chicago Cubs, Washington Senators, Buffalo Buffeds |
| Admiral Schlei | April 24, 1904 | April 24, 1911 | Catcher | Cincinnati Reds, New York Giants |
| Daniel Schlereth | May 29, 2009 | | Pitcher | Arizona Diamondbacks, Detroit Tigers |
| Rudy Schlesinger | May 4, 1965 | May 4, 1965 | Pinch hitter | Boston Red Sox |
| Travis Schlichting | June 7, 2009 | | Pitcher | Los Angeles Dodgers |
| Dutch Schliebner | April 17, 1923 | October 7, 1923 | First baseman | Brooklyn Robins, St. Louis Browns |
| Brian Schlitter | June 28, 2010 | | Pitcher | Chicago Cubs |
| Biff Schlitzer | April 17, 1908 | May 1, 1914 | Pitcher | Philadelphia Athletics, Boston Red Sox, Buffalo Buffeds |
| Jay Schlueter | June 18, 1971 | July 25, 1971 | Outfielder | Houston Astros |
| Norm Schlueter | May 28, 1938 | October 1, 1944 | Catcher | Chicago White Sox, Cleveland Indians |
| Brian Schmack | August 24, 2003 | September 27, 2003 | Pitcher | Detroit Tigers |
| Ray Schmandt | June 24, 1915 | October 1, 1922 | First baseman | St. Louis Browns, Brooklyn Robins |
| George Schmees | April 15, 1952 | September 28, 1952 | Outfielder | St. Louis Browns, Boston Red Sox |
| Al Schmelz | September 7, 1967 | September 24, 1967 | Pitcher | New York Mets |
| Bob Schmidt | April 16, 1958 | June 9, 1965 | Catcher | San Francisco Giants, Cincinnati Reds, Washington Senators (1961–1971), New York Yankees |
| Boss Schmidt | April 30, 1906 | October 8, 1911 | Catcher | Detroit Tigers |
| Butch Schmidt | May 11, 1909 | September 10, 1915 | First baseman | New York Highlanders, Boston Braves |
| Curt Schmidt | April 28, 1995 | September 29, 1995 | Pitcher | Montreal Expos |
| Dave Schmidt (P) | May 1, 1981 | May 26, 1992 | Pitcher | Texas Rangers, Chicago White Sox, Baltimore Orioles, Montreal Expos, Seattle Mariners |
| Dave Schmidt (C) | April 28, 1981 | June 3, 1981 | Catcher | Boston Red Sox |
| Freddy Schmidt | April 25, 1944 | September 24, 1947 | Pitcher | St. Louis Cardinals, Philadelphia Phillies, Chicago Cubs |
| Henry Schmidt | April 17, 1903 | September 22, 1903 | Pitcher | Brooklyn Superbas |
| Jason Schmidt | April 28, 1995 | | Pitcher | Atlanta Braves, Pittsburgh Pirates, San Francisco Giants, Los Angeles Dodgers |
| Jeff Schmidt | May 17, 1996 | July 30, 1996 | Pitcher | California Angels |
| Konrad Schmidt | September 13, 2010 | | Catcher | Arizona Diamondbacks |
| Mike Schmidt β | September 12, 1972 | May 28, 1989 | Third baseman | Philadelphia Phillies |
| Pete Schmidt | July 14, 1913 | July 14, 1913 | Pitcher | St. Louis Browns |
| Walter Schmidt | April 13, 1916 | September 7, 1925 | Catcher | Pittsburgh Pirates, St. Louis Cardinals |
| Willard Schmidt | April 19, 1952 | September 26, 1959 | Pitcher | St. Louis Cardinals, Cincinnati Reds |
| Crazy Schmit | April 21, 1890 | June 8, 1901 | Pitcher | Pittsburgh Alleghenys, Baltimore Orioles (19th century), New York Giants, Cleveland Spiders, Baltimore Orioles (1901–02) |
| Johnny Schmitz | September 6, 1941 | September 7, 1956 | Pitcher | Chicago Cubs, Brooklyn Dodgers, New York Yankees, Cincinnati Reds, Washington Senators, Boston Red Sox, Baltimore Orioles |
| Steve Schmoll | April 6, 2005 | October 2, 2005 | Pitcher | Los Angeles Dodgers |
| Hank Schmulbach | September 27, 1943 | September 27, 1943 | Pinch runner | St. Louis Browns |
| Charlie Schmutz | May 13, 1914 | April 14, 1915 | Pitcher | Brooklyn Robins |
| Dave Schneck | July 14, 1972 | October 1, 1974 | Outfielder | New York Mets |
| Frank Schneiberg | June 8, 1910 | June 8, 1910 | Pitcher | Brooklyn Superbas |
| Brian Schneider | May 26, 2000 | | Catcher | Montreal Expos, Washington Nationals, New York Mets, Philadelphia Phillies |
| Dan Schneider | May 12, 1963 | April 27, 1969 | Pitcher | Milwaukee/Atlanta Braves, Houston Astros |
| Jeff Schneider | August 12, 1981 | October 2, 1981 | Pitcher | Baltimore Orioles |
| Pete Schneider | June 20, 1914 | August 2, 1919 | Pitcher | Cincinnati Reds, New York Yankees |
| Karl Schnell | April 24, 1922 | April 19, 1923 | Pitcher | Cincinnati Reds |
| Gerry Schoen | September 14, 1968 | September 14, 1968 | Pitcher | Washington Senators (1961–1971) |
| Red Schoendienst β | April 17, 1945 | July 7, 1963 | Second baseman | St. Louis Cardinals, New York Giants, Milwaukee Braves |
| Jumbo Schoeneck | April 20, 1884 | May 11, 1889 | First baseman | Chicago Browns/Pittsburgh Stogies, Baltimore Monumentals, Indianapolis Hoosiers (NL) |
| Scott Schoeneweis | April 7, 1999 | | Pitcher | Anaheim Angels, Chicago White Sox, Toronto Blue Jays, Cincinnati Reds, New York Mets, Arizona Diamondbacks, Boston Red Sox |
| Dick Schofield | September 8, 1983 | September 29, 1996 | Shortstop | California Angels, New York Mets, Toronto Blue Jays, Los Angeles Dodgers |
| Ducky Schofield | July 5, 1953 | September 30, 1971 | Shortstop | St. Louis Cardinals, Pittsburgh Pirates, San Francisco Giants, New York Yankees, Los Angeles Dodgers, Boston Red Sox, Milwaukee Brewers |
| Otto Schomberg | July 7, 1886 | July 14, 1888 | First baseman | Pittsburgh Alleghenys, Indianapolis Hoosiers (NL) |
| Mike Schooler | June 10, 1988 | September 3, 1993 | Pitcher | Seattle Mariners, Texas Rangers |
| Jerry Schoonmaker | June 11, 1955 | September 29, 1957 | Outfielder | Washington Senators |
| Ed Schorr | April 26, 1915 | September 23, 1915 | Pitcher | Chicago Cubs |
| Gene Schott | April 16, 1935 | June 20, 1939 | Pitcher | Cincinnati Reds, Philadelphia Phillies |
| Pete Schourek | April 9, 1991 | July 25, 2001 | Pitcher | New York Mets, Cincinnati Reds, Houston Astros, Boston Red Sox, Pittsburgh Pirates |
| Paul Schramka | April 14, 1953 | April 16, 1953 | Outfielder | Chicago Cubs |
| Ossee Schreckengost | September 8, 1897 | October 2, 1908 | Catcher | Louisville Colonels, Cleveland Spiders, St. Louis Perfectos, Boston Americans, Cleveland Bronchos, Philadelphia Athletics, Chicago White sox |
| Barney Schreiber | May 15, 1911 | June 4, 1911 | Pitcher | Cincinnati Reds |
| Hank Schreiber | April 14, 1914 | August 5, 1926 | Third baseman | Chicago White Sox, Boston Braves, Cincinnati Reds, New York Giants, Chicago Cubs |
| Paul Schreiber | September 2, 1922 | September 8, 1945 | Pitcher | Brooklyn Robins, New York Yankees |
| Ted Schreiber | April 14, 1963 | September 29, 1963 | Third baseman | New York Mets |
| Steve Schrenk | July 3, 1999 | July 16, 2000 | Pitcher | Philadelphia Phillies |
| Pop Schriver | April 29, 1886 | October 6, 1901 | Catcher | Brooklyn Grays, Philadelphia Quakers (NL), Chicago Colts, New York Giants, Cincinnati Reds, Pittsburgh Pirates, St. Louis Cardinals |
| Bob Schroder | April 20, 1965 | September 29, 1968 | Second baseman | San Francisco Giants |
| Chris Schroder | August 8, 2006 | | Pitcher | Washington Nationals |
| Bill Schroeder | July 13, 1983 | September 9, 1990 | Catcher | Milwaukee Brewers, California Angels |
| Al Schroll | April 20, 1958 | October 1, 1961 | Pitcher | Boston Red Sox, Philadelphia Phillies, Chicago Cubs, Minnesota Twins |
| Ken Schrom | August 8, 1980 | October 3, 1987 | Pitcher | Toronto Blue Jays, Minnesota Twins, Cleveland Indians |
| Rick Schu | September 1, 1984 | August 14, 1996 | Third baseman | Philadelphia Phillies, Baltimore Orioles, Detroit Tigers, California Angels, Montreal Expos |
| Heinie Schuble | July 8, 1927 | May 15, 1936 | Shortstop | St. Louis Cardinals, Detroit Tigers |
| Ron Schueler | April 16, 1972 | July 4, 1979 | Pitcher | Atlanta Braves, Philadelphia Phillies, Minnesota Twins, Chicago White Sox |
| Dave Schuler | September 17, 1979 | October 2, 1985 | Pitcher | California Angels, Atlanta Braves |
| Erik Schullstrom | July 18, 1994 | September 27, 1995 | Pitcher | Minnesota Twins |
| Wes Schulmerich | May 1, 1931 | September 30, 1934 | Outfielder | Boston Braves, Philadelphia Phillies, Cincinnati Reds |
| Art Schult | May 17, 1953 | May 27, 1960 | Utility infielder | New York Yankees, Cincinnati Reds, Washington Senators, Chicago Cubs |
| Frank Schulte | September 21, 1904 | September 2, 1918 | Outfielder | Chicago Cubs, Pittsburgh Pirates, Philadelphia Phillies, Washington Senators |
| Fred Schulte | April 15, 1927 | October 3, 1937 | Outfielder | St. Louis Browns, Washington Senators, Pittsburgh Pirates |
| Ham Schulte | April 16, 1940 | September 29, 1940 | Second baseman | Philadelphia Phillies |
| Jack Schulte | August 19, 1906 | August 19, 1906 | Shortstop | Boston Beaneaters |
| Johnny Schulte | April 18, 1923 | September 20, 1932 | Catcher | St. Louis Browns, St. Louis Cardinals, Philadelphia Phillies, Chicago Cubs, Boston Braves |
| Len Schulte | September 27, 1944 | June 16, 1946 | Third baseman | St. Louis Browns |
| Barney Schultz | April 12, 1955 | September 6, 1965 | Pitcher | St. Louis Cardinals, Detroit Tigers, Chicago Cubs |
| Bob Schultz | April 20, 1951 | April 15, 1955 | Pitcher | Chicago Cubs, Pittsburgh Pirates, Detroit Tigers |
| Buddy Schultz | September 3, 1975 | September 28, 1979 | Pitcher | Chicago Cubs, St. Louis Cardinals |
| Howie Schultz | August 16, 1943 | September 8, 1948 | First baseman | Brooklyn Dodgers, Philadelphia Phillies, Cincinnati Reds |
| Joe Schultz (OF) | September 28, 1912 | October 4, 1925 | Outfielder | Boston Braves, Brooklyn Robins, Chicago Cubs, Pittsburgh Pirates, St. Louis Cardinals, Philadelphia Phillies, Cincinnati Reds |
| Joe Schultz (C) | September 27, 1939 | September 23, 1948 | Catcher | Pittsburgh Pirates, St. Louis Browns |
| John Schultz (P) | May 6, 1891 | June 11, 1891 | Catcher | Philadelphia Phillies |
| Mike Schultz (LHP) | April 20, 1947 | April 20, 1947 | Pitcher | Cincinnati Reds |
| Mike Schultz (RHP) | April 20, 2007 | | Pitcher | Arizona Diamondbacks |
| Webb Schultz | August 3, 1924 | August 3, 1924 | Pitcher | Chicago White Sox |
| Al Schulz | September 25, 1912 | September 23, 1916 | Pitcher | New York Highlanders, Buffalo Buffeds/Blues, Cincinnati Reds |
| Jeff Schulz | September 2, 1989 | May 15, 1991 | Outfielder | Kansas City Royals, Pittsburgh Pirates |
| Walt Schulz | September 24, 1920 | September 24, 1920 | Pitcher | St. Louis Cardinals |
| Don Schulze | September 13, 1983 | September 29, 1989 | Pitcher | Chicago Cubs, Cleveland Indians, New York Mets, New York Yankees, San Diego Padres |
| John Schulze | August 7, 1891 | August 7, 1891 | Catcher | St. Louis Browns (1882–1900) |
| Hal Schumacher | April 15, 1931 | September 26, 1946 | Pitcher | New York Giants |
| Skip Schumaker | June 8, 2005 | | Outfielder | St. Louis Cardinals |
| Hack Schumann | September 19, 1906 | October 3, 1906 | Pitcher | Philadelphia Athletics |
| Ferdie Schupp | August 19, 1913 | July 27, 1922 | Pitcher | San Francisco Giants, St. Louis Cardinals, Brooklyn Robins, Chicago White Sox |
| Wayne Schurr | April 15, 1964 | July 11, 1964 | Pitcher | Chicago Cubs |
| Bill Schuster | September 29, 1937 | September 29, 1945 | Shortstop | Pittsburgh Pirates, Boston Braves, Chicago Cubs |
| Carl Schutz | September 3, 1996 | September 24, 1996 | Pitcher | Atlanta Braves |
| Mike Schwabe | May 27, 1989 | July 20, 1990 | Pitcher | Detroit Tigers |
| Don Schwall | May 21, 1961 | April 12, 1967 | Pitcher | Boston Red Sox, Pittsburgh Pirates, Atlanta Braves |
| Ralph Schwamb | July 25, 1948 | September 18, 1948 | Pitcher | St. Louis Browns |
| Bill Schwartz (C) | May 3, 1883 | August 7, 1884 | Catcher | Columbus Buckeyes, Cincinnati Outlaw Reds |
| Bill Schwartz (1B) | May 2, 1904 | June 16, 1904 | First baseman | Cleveland Naps |
| Randy Schwartz | September 8, 1965 | September 24, 1966 | First baseman | Kansas City Athletics |
| Jeff Schwarz | April 24, 1993 | August 6, 1994 | Pitcher | Chicago White Sox, California Angels |
| Al Schweitzer | April 30, 1908 | October 8, 1911 | Outfielder | St. Louis Browns |
| Rudy Schwenck | September 23, 1908 | October 6, 1908 | Pitcher | Chicago Cubs |
| Hal Schwenk | September 4, 1913 | September 4, 1913 | Pitcher | St. Louis Browns |
| Pi Schwert | October 6, 1914 | October 7, 1915 | Catcher | New York Yankees |
| Michael Schwimer | August 21, 2011 | | Pitcher | Philadelphia Phillies |
| Art Schwind | October 3, 1912 | October 3, 1912 | Third baseman | Boston Braves |
| Chris Schwinden | September 8, 2011 | | Pitcher | New York Mets |
| Jerry Schypinski | August 31, 1955 | September 25, 1955 | Shortstop | Kansas City Athletics |
| Mike Scioscia | April 20, 1980 | October 2, 1992 | Catcher | Los Angeles Dodgers |
| Lou Scoffic | April 16, 1936 | May 9, 1936 | Outfielder | St. Louis Cardinals |
| Jim Scoggins | August 26, 1913 | August 26, 1913 | Pitcher | Chicago White Sox |
| Daryl Sconiers | September 13, 1981 | October 6, 1985 | First baseman | California Angels |
| Herb Score | April 15, 1955 | May 4, 1962 | Pitcher | Cleveland Indians, Chicago White Sox |
| Scott, first name unknown | July 16, 1884 | August 5, 1884 | Outfielder | Baltimore Monumentals |
| Darryl Scott | May 31, 1993 | October 1, 1993 | Pitcher | California Angels |
| Dick Scott (RHP) | June 26, 1901 | July 8, 1901 | Pitcher | Cincinnati Reds |
| Dick Scott (LHP) | May 8, 1963 | July 10, 1964 | Pitcher | Los Angeles Dodgers, Chicago Cubs |
| Dick Scott (SS) | May 19, 1989 | May 29, 1989 | Shortstop | Oakland Athletics |
| Donnie Scott | September 30, 1983 | October 4, 1991 | Catcher | Texas Rangers, Seattle Mariners, Cincinnati Reds |
| Ed Scott | April 19, 1900 | August 3, 1901 | Pitcher | Cincinnati Reds, Cleveland Blues (AL) |
| Everett Scott | April 14, 1914 | July 27, 1926 | Shortstop | Boston Red Sox, New York Yankees, Washington Senators, Chicago White Sox, Cincinnati Reds |
| Gary Scott | April 9, 1991 | October 3, 1992 | Third baseman | Chicago Cubs |
| George Scott (P) | September 13, 1920 | September 13, 1920 | Pitcher | St. Louis Cardinals |
| George Scott (1B) | April 12, 1966 | September 27, 1979 | First baseman | Boston Red Sox, Milwaukee Brewers, Kansas City Royals, New York Yankees |
| Jack Scott | September 6, 1916 | September 22, 1929 | Pitcher | Pittsburgh Pirates, Boston Braves, Cincinnati Reds, New York Giants |
| Jim Scott (P) | April 25, 1909 | August 17, 1917 | Pitcher | Chicago White Sox |
| Jim Scott (SS) | April 22, 1914 | May 1, 1914 | Shortstop | Pittsburgh Rebels |
| John Scott | September 7, 1974 | September 27, 1977 | Outfielder | San Diego Padres, Toronto Blue Jays |
| Lefty Scott | June 15, 1945 | July 12, 1945 | Pitcher | Philadelphia Phillies |
| LeGrant Scott | April 19, 1939 | August 5, 1939 | Outfielder | Philadelphia Phillies |
| Luke Scott | April 5, 2005 | | Outfielder | Houston Astros, Baltimore Orioles |
| Mickey Scott | May 6, 1972 | June 6, 1977 | Pitcher | Baltimore Orioles, Montreal Expos, California Angels |
| Mike Scott | April 18, 1979 | April 13, 1991 | Pitcher | New York Mets, Houston Astros |
| Milt Scott | September 30, 1882 | October 14, 1886 | First baseman | Chicago White Stockings, Detroit Wolverines, Pittsburgh Alleghenys, Baltimore Orioles (19th century) |
| Pete Scott | April 13, 1926 | September 27, 1928 | Outfielder | Chicago Cubs, Pittsburgh Pirates |
| Rodney Scott | April 11, 1975 | August 21, 1982 | Second baseman | Kansas City Royals, Montreal Expos, Oakland Athletics, Chicago Cubs, New York Yankees |
| Tim Scott | June 25, 1991 | July 2, 1997 | Pitcher | San Diego Padres, Montreal Expos, San Francisco Giants, Colorado Rockies |
| Tony Scott | September 1, 1973 | September 21, 1984 | Outfielder | Montreal Expos, St. Louis Cardinals, Houston Astros |
| Jim Scranton | September 5, 1984 | October 6, 1985 | Shortstop | Kansas City Royals |
| Evan Scribner | April 26, 2011 | | Pitcher | San Diego Padres |
| Chuck Scrivener | September 18, 1975 | September 29, 1977 | Shortstop | Detroit Tigers |
| Tony Scruggs | April 8, 1991 | April 20, 1991 | Outfielder | Texas Rangers |
| Scott Scudder | June 6, 1989 | May 22, 1993 | Pitcher | Cincinnati Reds, Cleveland Indians |
| Rod Scurry | April 17, 1980 | September 30, 1988 | Pitcher | Pittsburgh Pirates, New York Yankees, Seattle Mariners |
| Marco Scutaro | July 21, 2002 | | Utility infielder | New York Mets, Oakland Athletics, Toronto Blue Jays, Boston Red Sox |
| Scott Seabol | April 8, 2001 | September 30, 2005 | Third baseman | New York Yankees, St. Louis Cardinals |
| Kyle Seager | July 7, 2011 | | Infielder | Seattle Mariners |
| Johnnie Seale | September 20, 1964 | May 2, 1965 | Pitcher | Detroit Tigers |
| Kim Seaman | September 28, 1979 | September 27, 1980 | Pitcher | St. Louis Cardinals |
| Rudy Seánez | September 7, 1989 | | Pitcher | Cleveland Indians, San Diego Padres, Los Angeles Dodgers, Atlanta Braves, Texas Rangers, Boston Red Sox, Kansas City Royals, Florida Marlins, Philadelphia Phillies |
| Ray Searage | June 11, 1981 | September 30, 1990 | Pitcher | New York Mets, Milwaukee Brewers, Chicago White Sox, Los Angeles Dodgers |
| Steve Searcy | August 29, 1988 | June 1, 1992 | Pitcher | Detroit Tigers, Philadelphia Phillies |
| Ken Sears | May 2, 1943 | July 3, 1946 | Catcher | New York Yankees, St. Louis Browns |
| Todd Sears | September 17, 2002 | September 27, 2003 | First baseman | Minnesota Twins, San Diego Padres |
| Tom Seaton | April 13, 1912 | June 23, 1917 | Pitcher | Philadelphia Phillies, Brooklyn Tip-Tops, Newark Peppers, Chicago Cubs |
| Tom Seats | May 4, 1940 | September 28, 1945 | Pitcher | Detroit Tigers, Brooklyn Dodgers |
| Tom Seaver β | April 13, 1967 | September 19, 1986 | Pitcher | New York Mets, Cincinnati Reds, Chicago White Sox, Boston Red Sox |
| Bobby Seay | August 14, 2001 | | Pitcher | Tampa Bay Devil Rays, Colorado Rockies, Detroit Tigers |
| Bob Sebra | June 26, 1985 | June 30, 1990 | Pitcher | Texas Rangers, Montreal Expos, Philadelphia Phillies, Cincinnati Reds, Milwaukee Brewers |
| Jimmy Sebring | September 8, 1902 | August 6, 1909 | Outfielder | Pittsburgh Pirates, Cincinnati Reds, Brooklyn Superbas, Washington Senators |
| Doc Sechrist | April 28, 1899 | April 28, 1899 | Pitcher | New York Giants |
| Frank Secory | April 28, 1940 | August 10, 1946 | Outfielder | Detroit Tigers, Cincinnati Reds, Chicago Cubs |
| Don Secrist | April 11, 1969 | June 27, 1970 | Pitcher | Chicago White Sox |
| Chris Seddon | September 3, 2007 | | Pitcher | Florida Marlins, Seattle Mariners |
| Duke Sedgwick | July 12, 1921 | July 30, 1923 | Pitcher | Philadelphia Phillies, Washington Senators |
| Shawn Sedlacek | June 18, 2002 | September 27, 2002 | Pitcher | Kansas City Royals |
| Charlie See | August 6, 1919 | July 8, 1921 | Outfielder | Cincinnati Reds |
| Larry See | September 3, 1986 | August 16, 1988 | First baseman | Los Angeles Dodgers, Texas Rangers |
| Bob Seeds | April 19, 1930 | September 24, 1940 | Outfielder | Cleveland Indians, Chicago White Sox, Boston Red Sox, New York Yankees, New York Giants |
| Chris Seelbach | September 9, 2000 | May 20, 2001 | Pitcher | Atlanta Braves |
| Chuck Seelbach | June 29, 1971 | May 23, 1974 | Pitcher | Detroit Tigers |
| Pat Seerey | June 9, 1943 | May 7, 1949 | Outfielder | Cleveland Indians, Chicago White Sox |
| Emmett Seery | April 17, 1884 | June 10, 1892 | Outfielder | Baltimore Monumentals, Kansas City Cowboys (UA), St. Louis Maroons, Indianapolis Hoosiers (NL), Brooklyn Ward's Wonders, Cincinnati Kelly's Killers, Louisville Colonels |
| Kevin Sefcik | September 8, 1995 | June 1, 2001 | Outfielder | Philadelphia Phillies, Colorado Rockies |
| Herman Segelke | April 7, 1982 | April 23, 1982 | Pitcher | Chicago Cubs |
| Zack Segovia | April 8, 2007 | | Pitcher | Philadelphia Phillies, Washington Nationals |
| Kal Segrist | July 16, 1952 | September 25, 1955 | Second baseman | New York Yankees, Baltimore Orioles |
| David Segui | May 8, 1990 | September 8, 2004 | First baseman | Baltimore Orioles, New York Mets, Montreal Expos, Seattle Mariners, Toronto Blue Jays, Texas Rangers, Cleveland Indians |
| Diego Seguí | April 12, 1962 | September 24, 1977 | Pitcher | Kansas City Athletics, Washington Senators (1961–1971), Oakland Athletics, Seattle Pilots, St. Louis Cardinals, Boston Red Sox, Seattle Mariners |
| Fernando Seguignol | September 5, 1998 | September 28, 2003 | Utility player | Montreal Expos, New York Yankees |
| José Segura | April 10, 1988 | July 4, 1991 | Pitcher | Chicago White Sox, San Francisco Giants |
| Phil Seibel | April 15, 2004 | April 18, 2004 | Pitcher | Boston Red Sox |
| Kurt Seibert | September 3, 1979 | September 30, 1979 | Second baseman | Chicago Cubs |
| Socks Seibold | September 18, 1915 | June 13, 1933 | Pitcher | Philadelphia Athletics, Boston Braves |
| Ricky Seilheimer | July 5, 1980 | August 8, 1980 | Catcher | Chicago White Sox |
| Kevin Seitzer | September 3, 1986 | September 28, 1997 | Third baseman | Kansas City Royals, Milwaukee Brewers, Oakland Athletics, Cleveland Indians |
| Kip Selbach | April 24, 1894 | June 29, 1906 | Outfielder | Washington Senators (1891–99), Cincinnati Reds, New York Giants, Baltimore Orioles (1901–1902), Washington Senators, Boston Americans |
| Bill Selby | April 19, 1996 | May 25, 2003 | Utility player | Boston Red Sox, Cleveland Indians, Cincinnati Reds |
| Aaron Sele | June 23, 1993 | September 23, 2007 | Pitcher | Boston Red Sox, Texas Rangers, Seattle Mariners, Anaheim Angels, Los Angeles Dodgers, New York Mets |
| Todd Self | May 12, 2005 | June 9, 2005 | Outfielder | Houston Astros |
| George Selkirk | August 12, 1934 | September 27, 1942 | Outfielder | New York Yankees |
| Epp Sell | September 1, 1922 | May 29, 1923 | Pitcher | St. Louis Cardinals |
| Jeff Sellers | September 15, 1985 | October 1, 1988 | Pitcher | Boston Red Sox |
| Justin Sellers | August 12, 2011 | | Infielder | Los Angeles Dodgers |
| Rube Sellers | August 12, 1910 | October 4, 1910 | Outfielder | Boston Doves |
| Frank Sellman | May 4, 1871 | May 3, 1875 | Utility player | Fort Wayne Kekiongas, Washington Olympics, Baltimore Marylands, Baltimore Canaries, Washington Nationals (NA) |
| Dave Sells | August 2, 1972 | September 22, 1975 | Pitcher | California Angels, Los Angeles Dodgers |
| Dick Selma | September 2, 1965 | August 9, 1974 | Pitcher | New York Mets, San Diego Padres, Chicago Cubs, Philadelphia Phillies, California Angels, Milwaukee Brewers |
| Carey Selph | May 25, 1929 | September 18, 1932 | Third baseman | St. Louis Cardinals, Chicago White Sox |
| Mike Sember | August 18, 1977 | October 1, 1978 | Third baseman | Chicago Cubs |
| Carroll Sembera | September 28, 1965 | April 26, 1970 | Pitcher | Houston Astros, Montreal Expos |
| Frank Seminara | June 2, 1992 | June 5, 1994 | Pitcher | San Diego Padres, New York Mets |
| Andy Seminick | September 14, 1943 | September 21, 1957 | Catcher | Philadelphia Phillies, Cincinnati Reds |
| Ray Semproch | April 15, 1958 | May 2, 1961 | Pitcher | Philadelphia Phillies, Detroit Tigers, Los Angeles Angels |
| Sonny Senerchia | August 22, 1952 | September 28, 1952 | Third baseman | Pittsburgh Pirates |
| Count Sensenderfer | May 20, 1871 | October 21, 1874 | Outfielder | Philadelphia Athletics (1860–76) |
| Paul Sentell | April 12, 1906 | April 27, 1907 | Third baseman | Philadelphia Phillies |
| Steve Senteney | June 6, 1982 | September 30, 1982 | Pitcher | Toronto Blue Jays |
| Jae Weong Seo | July 21, 2002 | | Pitcher | New York Mets, Los Angeles Dodgers, Tampa Bay Devil Rays |
| Manny Seoane | September 18, 1977 | September 30, 1978 | Pitcher | Philadelphia Phillies, Chicago Cubs |
| Ted Sepkowski | September 9, 1942 | June 21, 1947 | Utility infielder | Cleveland Indians, New York Yankees |
| Billy Serad | May 5, 1884 | July 7, 1888 | Pitcher | Buffalo Bisons (NL), Cincinnati Red Stockings (AA) |
| Dan Serafini | June 25, 1996 | | Pitcher | Minnesota Twins, Chicago Cubs, San Diego Padres, Pittsburgh Pirates, Cincinnati Reds, Colorado Rockies |
| Bill Serena | September 16, 1949 | August 7, 1954 | Third baseman | Chicago Cubs |
| Paul Serna | September 1, 1981 | October 3, 1982 | Shortstop | Seattle Mariners |
| Alex Serrano | April 16, 2008 | | Pitcher | Los Angeles Angels of Anaheim |
| Jimmy Serrano | August 7, 2004 | October 3, 2008 | Pitcher | Kansas City Royals |
| Wascar Serrano | May 12, 2001 | October 5, 2001 | Pitcher | San Diego Padres |
| Gary Serum | July 22, 1977 | September 29, 1979 | Pitcher | Minnesota Twins |
| Scott Servais | July 12, 1991 | September 21, 2001 | Catcher | Houston Astros, Chicago Cubs, Colorado Rockies, San Francisco Giants |
| Scott Service | September 5, 1988 | September 26, 2004 | Pitcher | Philadelphia Phillies, Montreal Expos, Colorado Rockies, Cincinnati Reds, San Francisco Giants, Kansas City Royals, Oakland Athletics, Arizona Diamondbacks, Toronto Blue Jays |
| Walter Sessi | September 18, 1941 | September 27, 1946 | Outfielder | St. Louis Cardinals |
| Merle Settlemire | April 13, 1928 | September 29, 1928 | Pitcher | Boston Red Sox |
| John Sevcik | April 24, 1965 | October 3, 1965 | Catcher | Minnesota Twins |
| Hank Severeid | May 15, 1911 | July 27, 1926 | Catcher | Cincinnati Reds, St. Louis Browns, Washington Senators, New York Yankees |
| Atahualpa Severino | September 6, 2011 | | Pitcher | Washington Nationals |
| Al Severinsen | July 1, 1969 | September 14, 1972 | Pitcher | Baltimore Orioles, San Diego Padres |
| Rich Severson | April 10, 1970 | September 29, 1971 | Shortstop | Kansas City Royals |
| Ed Seward | September 30, 1885 | June 8, 1891 | Pitcher | Providence Grays, Philadelphia Athletics (AA), Cleveland Spiders |
| Frank Seward | September 28, 1943 | September 22, 1944 | Pitcher | New York Giants |
| George Seward | May 19, 1875 | August 8, 1882 | Outfielder | St. Louis Brown Stockings, New York Mutuals, St. Louis Brown Stockings (AA) |
| Joe Sewell β | September 10, 1920 | September 24, 1933 | Shortstop | Cleveland Indians, New York Yankees |
| Luke Sewell | June 30, 1921 | August 1, 1942 | Catcher | Cleveland Indians, Washington Senators, Chicago White Sox, St. Louis Browns |
| Rip Sewell | June 14, 1932 | September 18, 1949 | Pitcher | Detroit Tigers, Pittsburgh Pirates |
| Tommy Sewell | June 21, 1927 | June 21, 1927 | Pinch hitter | Chicago Cubs |
| Elmer Sexauer | September 6, 1948 | September 12, 1948 | Pitcher | Brooklyn Dodgers |
| Richie Sexson | September 14, 1997 | August 13, 2008 | First baseman | Cleveland Indians, Milwaukee Brewers, Arizona Diamondbacks, Seattle Mariners, New York Yankees |
| Chris Sexton | May 3, 1999 | October 1, 2000 | Utility player | Colorado Rockies, Cincinnati Reds |
| Frank Sexton | June 21, 1895 | August 17, 1895 | Pitcher | Boston Beaneaters |
| Jimmy Sexton | September 2, 1977 | October 2, 1983 | Shortstop | Seattle Mariners, Houston Astros, Oakland Athletics, St. Louis Cardinals |
| Tom Sexton | September 27, 1884 | October 12, 1884 | Shortstop | Milwaukee Brewers (UA) |
| Socks Seybold | August 20, 1899 | October 7, 1908 | Outfielder | Cincinnati Reds, Philadelphia Athletics |
| Gordon Seyfried | September 13, 1963 | April 28, 1964 | Pitcher | Cleveland Indians |
| Cy Seymour | April 22, 1896 | July 17, 1913 | Outfielder | New York Giants, Baltimore Orioles (1901–1902), Cincinnati Reds, Boston Braves |
| Jake Seymour | September 23, 1882 | September 23, 1882 | Pitcher | Pittsburgh Alleghenys |