OpenLLM-France/wikimedia huggingface dataset:
# Jordan's syndrome

Jordan's syndrome (JS) or PPP2R5D-related intellectual disability is a rare autosomal dominant neurodevelopmental disorder caused by de novo mutations in the PPP2R5D gene. Children with JS may also have epilepsy or meet criteria for diagnosis with autism spectrum disorder.

## Signs and symptoms

Symptoms of Jordan's syndrome (JS) are not formally defined but typically appear in early childhood and can range from mild to severe global developmental delay and intellectual disability, usually including speech delay and impairment. Patients with JS may meet some or all criteria for diagnosis with autism spectrum disorder due to many shared developmental symptoms. Initial clinical findings may include macrocephaly, hypotonia, epilepsy, ophthalmologic abnormalities, and dysmorphic facial features. Magnetic resonance imaging may further reveal megalencephaly or defects of the ventricles or white matter. Individuals with JS may also have skeletal, cardiac, endocrine, or genital abnormalities. Certain JS mutations can also cause early-onset parkinsonism between ages 20 and 40.

## Genetics

All cases of JS are caused by de novo missense point mutations in PPP2R5D, which encodes a subunit of the enzyme PP2A. At least eight pathogenic mutations have been identified: E197K, E198K, E200K, E420K, P201R, W207R, Q211P, and P53S.
Patients are exclusively diagnosed with JS upon discovery of a pathogenic variant of PPP2R5D via genetic testing. As of 2019, at least 23 individuals with JS have been reported.

## Mechanisms

The molecular mechanisms underlying JS are unknown. Broadly, PP2A dysfunction is known to be associated with other pathologies such as Alzheimer's disease, Parkinson's disease, and cancer. Studies of specific JS-causing variants such as E420K have implicated PI3K/AKT/mTOR pathway dysregulation in JS pathogenesis.

## Diagnosis

Jordan's syndrome is diagnosed through molecular genetic testing, most commonly exome sequencing.

## Research

PPP2R5D-related intellectual disability was named "Jordan's syndrome" after Jordan Lang, who was diagnosed by whole exome sequencing in 2014. Lang's parents founded the charitable organization Jordan's Guardian Angels to connect families of individuals with JS. The foundation also funds PPP2R5D research, spanning diverse model systems from alpacas and fruit flies to patient-derived induced pluripotent stem cells. Ten primary investigators are affiliated with the foundation:
* Wendy Chung (Columbia University)
* Kyle Fink (University of California, Davis)
* Richard Honkanen (University of South Alabama)
* Veerle Janssens (Katholieke Universiteit Leuven)
* Ghayda Mirzaa (Seattle Children's Hospital)
* Jan Nolta (University of California, Davis)
* Stefan Strack (University of Iowa)
* Brian Wadzinski (Vanderbilt University)
* Houhui Xia (University of Rochester)
* Yongna Xing (McArdle Laboratory)
# Down to Earth

Down to Earth may refer to:

## Film and television
### Film

* Down to Earth (1917 film), an American comedy romance
* Down to Earth (1932 film), an American pre-Code comedy
* Down to Earth (1947 film), the sequel to Here Comes Mr. Jordan
* Down to Earth (1995 film), English title of the Portuguese film Casa de Lava
* Down to Earth (2001 film), a remake of the 1978 film Heaven Can Wait

### Television

* Down to Earth (American TV series), a 1984–1987 sitcom
* Down to Earth (1995 TV series), a British sitcom
* Down to Earth (2000 TV series), a 2000–2005 British drama
* Down to Earth with Zac Efron, a 2020–2022 American documentary series
* "Down to Earth" (Code Lyoko), a 2007 episode
* "Down to Earth" (McLeod's Daughters), a 2005 episode
* "Down to Earth" (The Outer Limits), a 2000 episode

## Literature

* Down to Earth (book), a 2008 Canadian student anthology
* "Down to Earth" (comics), a 2003–2004 Wonder Woman story arc
* Down to Earth (magazine), an Indian science and environment magazine
* Down to Earth: Australian Landscapes, a 1999 essay and photography collection
* "Down to Earth", a 1963 short story by Harry Harrison
* Down to Earth, a 2018 book by Bruno Latour

## Music

* Down to Earth (concert), a 2020 concert for bushfire relief during the 2019–20 Australian bushfire season

### Albums

* Down to Earth (Alexis & Fido album), 2009
* Down to Earth (Flight Facilities album) or the title song, 2014
* Down to Earth (Freddie Roach album), 1962
* Down to Earth (Jem album) or the title song, 2008
* Down to Earth (Jimmy Buffett album), 1970
* Down to Earth (Monie Love album) or the title song, 1990
* Down to Earth (Nektar album), 1974
* Down to Earth (Ozzy Osbourne album), 2001
* Down to Earth (Rainbow album), 1979
* Down to Earth (Ramsey Lewis album), 1958
* Down to Earth (Stevie Wonder album) or the title song, 1966
* Down to Earth (The Undisputed Truth album), 1974
* Down to Earth (soundtrack), from the 2001 film
* Down to Earth (EP), by Taeyang, 2023
* Down to Earth, by Nichelle Nichols, 1967
* Down 2 Earth, by Ras G, 2011

### Songs

* "Down to Earth" (Curiosity Killed the Cat song), 1986
* "Down to Earth" (Peter Gabriel song), 2008
* "Down to Earth", by the Bee Gees from Idea, 1968
* "Down to Earth", by Brett Kissel from What Is Life?, 2021
* "Down to Earth", by Celldweller from End of an Empire, 2015
* "Down to Earth", by Grace, 1996
* "Down to Earth", by Justin Bieber from My World, 2009

## Other uses

* Down to Earth (radio play), a 1939 Australian radio play by Catherine Shepherd
* Down to Earth co-operative, a non-profit organization based in Melbourne, Australia
# Ángel Martín González (chess player)

Ángel Martín González (born 3 January 1953), is a Spanish chess International Master (IM) (1981), four times Spanish Chess Championship winner (1976, 1984, 1986, 2000).

## Biography

Ángel Martín González has competed many times in the finals of Spanish Chess Championships, where winning four gold medals (Ceuta 1976, Barcelona 1984, La Roda 1986, Manresa 2000) and three silver medals (Salamanca 1972, Valencia 1974, Torrevieja 1979). He was also the champion (1971) and runner-up (1972) of Catalonia Junior Chess Championship and six times Catalan Chess Championship winner (1974, 1979, 1980, 1984, 1997, 2000) and two-time runner-up (1986, 1992). In 1987, he won the 2nd place in Spain Blitz Chess Championship.
In 1985 in Biel Ángel Martín González participated in the World Chess Championship Interzonal Tournament where ranked in 18th place.
Ángel Martín González has achieved several successes in international chess tournaments, including in Alicante (1977, shared 2nd place), Rome (1982, 1st place), Barcelona (1986, 1st place; 1988, 2nd place and 1991, shared 2nd place), Sant Cugat del Vallès (1994, shared 1st place) and in Sant Feliu de Guíxols (2000, shared 1st place).
Ángel Martín González played for Spain in the Chess Olympiads:
* In 1976, at third board in the 22nd Chess Olympiad in Haifa (+4, =3, -4),
* In 1982, at fourth board in the 25th Chess Olympiad in Lucerne (+2, =4, -3),
* In 1984, at fourth board in the 26th Chess Olympiad in Thessaloniki (+1, =5, -4),
* In 1986, at first reserve board in the 27th Chess Olympiad in Dubai (+3, =1, -3).
Ángel Martín González played for Spain in the Clare Benedict Chess Cups:
* In 1977, at reserve board in the 22nd Clare Benedict Chess Cup in Copenhagen (+4, =3, -0).
In 1981, he was awarded the FIDE International Master (IM) title.
# Fyodor Stepun

Fyodor Avgustovich Stepun (Russian: Фёдор А́вгустович Степу́н; February 18, 1884 – February 23, 1965) (also known as Friedrich Steppuhn) was a Russian and German writer, philosopher, historian and sociologist.

## Biography

Fyodor Avgustovich Stepun was born in Russia on 18 February 1884, in Moscow. After attending secondary school in Moscow he went as a student to Heidelberg, and there in 1910 he obtained his doctorate for a thesis on Vladimir Solovyov's philosophy of history.
Between 1910 and 1914 Stepun edited the international philosophical journal, Logos, and travelled across Russia lecturing on philosophy, literature and culture.
During the first World War he was an officer in a Siberian regiment, and after the Russian revolution was an army commissar under the Russian Provisional Government.
From 1920 to 1922 he directed the state experimental theatre; but in 1922 he was deported from the Soviet Union. He settled in Germany, working first in Berlin, and afterwards as a professor of sociology in Dresden (1926–1937). During this period he published in Russian his books on 'Life and creation' (1923) and 'Letters of an Artillery Ensign' (1925), as well as Wie war es möglich? (1929), Das Antlitz Russlands und das Gesicht der Revolution (1934) and The Russian Soul and Revolution (1936). In 1937 he was expelled from his teaching-post by the Nazi authorities.
From 1946 he worked as a professor of Russian cultural studies at Munich University, and published several works: Vergangenes und Unvergängliches (1947; Russian version, Byvshee i Nesbyvsheesya, 1956), Theater und Film (1953), Der Bolschewismus und die Christliche Existenz (1959), and in Russian 'Encounters' (1962).
Stepun was a fierce opponent of Bolshevism, as well as Nazism. His philosophical doctrine has been described as neo-Kantist transcendentalism linked with religious metaphysics, close to the ideas of Vladimir Solovyov and Nikolai Berdyaev.
Stepun died on 23 February 1965.
# Vedh Bhavishyacha

Vedh Bhavishyacha (transl. Predict the future) is an Indian Marathi language astrological television show which is running on Zee Marathi. Pandit Atulshastri Bhagare Guruji hosts this show. The show premiered its second season from 8 June 2020 airing daily. It is Zee Marathi's third longest running Indian television show in Marathi language.

## Plot

An astrology expert predicts the future of the 12 zodiac signs on the basis of the positions of the planets and the stars. He also narrates and interprets the stories from ancient Hindu texts.

## Awards

Zee Marathi Utsav Natyancha Awards 2013 :
| Category | Recipient | Ref. |
| Best Anchor Male | Vijay Kelkar | |
# Ronel

Ronel (French pronunciation:; Languedocien: Ronèl) is a former commune in the Tarn department and Occitanie region of southern France. On 1 January 2019, it was merged into the new commune Terre-de-Bancalié.
# 1954 Cleveland Hill School District fire

The 1954 Cleveland Hill school fire was a fire and explosion that occurred on March 31, 1954 at the Cleveland Hill Union Free School District's elementary school facility annex in Cheektowaga, New York. The eight classroom wooden annex was added onto the existing brick school building to accommodate the influx of new students resulting from the "Baby Boom" following World War II.

## Incident

There was a sixth grade music class being held in the annex at the time of the explosion and fire which claimed the lives of 15 sixth-grade students along with injuring 19 students, three teachers and the school's principal. A student survivor later recounted he remembered a loud noise, followed seconds later by a doorway full of raging flames and pure panic.
Many students perished because they were unable to open the windows that were either locked or stuck. When the glass was broken to provide an avenue of escape they were cut trying to fit through the small size of the window panes. The cause of the fire was never determined but it may have been caused by a defective furnace that had been leaking fumes or possibly spontaneous combustion inside a storage closet.

## Victims

Of the 15 deceased victims, ten never made it out of the fire while the other five died due to their injuries.
Among those who survived but suffered severe burns was American folk musician Jackson C. Frank. The treatment of the burn victims from this fire was cited in later medical journals. Yet while many victims received high quality medical care, many highlighted how unprepared medical professionals, teachers, parents and friends were to deal with the tragedy and the magnitude of it and were often uncomfortable trying to discuss it.

## Aftermath

The annex facility was made entirely of wood and following the disaster there was a movement to introduce building codes that prohibited wooden buildings from housing schools. Other changes that came about because of the fire were fire drills, rules regarding window type and size, school construction methods and school communications with fire departments.
During the Erie county legislative chamber meeting on March 21, 2024, a new law was unveiled recognizing March 31st as a county-wide day of remembrance. This originally started as a bill created by the Cleveland Hill Union Free School District Middle School Youth and Government Club, with student Jax Keidel performing a speech. This clubs members attended the meeting, and at a point, were visible with the chair of the legislature.
# Pseudopanax laetus

Pseudopanax laetus, the shrub panax, is a species of flowering plant in the subfamily Aralioideae, family Araliaceae, native to the North Island of New Zealand. It is a member of the Neopanax clade, and occasionally referred to as Neopanax laetus. It has gained the Royal Horticultural Society's Award of Garden Merit.

## Range

Known from the North Island of New Zealand.

## Habitat

Forests in mountainous regions.
# Japanese destroyer Hatsuyuki (1906)

Hatsuyuki (初雪) ("First snow") was one of 32 Kamikaze-class destroyers built for the Imperial Japanese Navy (IJN) in the first decade of the 20th century.

## Design and description

The Kamikaze-class destroyers were improved versions of the preceding Harusame class. They displaced 381 long tons (387 t) at normal load and 450 long tons (460 t) at deep load. The ships had a length between perpendiculars of 227 feet (69.2 m) and an overall length of 234 feet (71.3 m), a beam of 21 feet 7 inches (6.6 m) and a draught of 6 feet (1.8 m). The Kamikazes were powered by two vertical triple-expansion steam engines, each driving one shaft using steam produced by four Kampon water-tube boilers. The engines produced a total of 6,000 indicated horsepower (4,500 kW) that gave the ships a maximum speed of 29 knots (54 km/h; 33 mph). They carried a maximum of 100 long tons (102 t) of coal which gave them a range of 1,500 nautical miles (2,800 km; 1,700 mi) at a speed of 15 knots (28 km/h; 17 mph). Their crew consisted of 70 officers and ratings.
The main armament of the Kamikaze-class ships consisted of two 40-calibre quick-firing (QF) three-inch (76 mm) 12 cwt guns on single mounts; the forward gun was located on superstructure, but the aft gun was at the stern. Four 28-calibre QF three-inch 8 cwt guns on single mounts were positioned abreast the superstructure, two in each broadside. The ships were also armed with two single rotating mounts for 450-millimetre (17.7 in) torpedoes between the superstructure and the stern gun. When Hatsuyuki was converted into a minesweeper in 1924, she was rearmed with a pair of 12-centimetre (4.7 in) 3rd Year Type guns taken from older ships on single mounts and the three-inch 8 cwt guns were removed.

## Construction and career

Hatsuyuki was launched at the Yokosuka Naval Arsenal on 8 March 1906 and completed on 17 May. The ship was converted into a minesweeper on 1 December 1924. She was decommissioned on 1 April 1928 and subsequently broken up.
# Derwent Reservoir (North East England)

The Derwent Reservoir is a reservoir on the River Derwent, on the border between County Durham and Northumberland, in England. It is west of Consett. It is 3.5 miles (5.6 km) long) and covers an area of 4 km$^2$ and has a maximum depth of 100 ft (30m) and when full, holds 11,000 million gallons (50,000,000m³).
The reservoir is a key part of the water supply network in north east England (which is owned and managed by Northumbrian Water). It is the principal water source for the Tyne and Wear metropolitan area, supplying 28,000,000 imperial gallons (130,000,000 L; 34,000,000 US gal) per day. The reservoir was first proposed in 1957 when the Sunderland and South Shields Water Company promoted the Derwent Water Order. Building work began on the reservoir in 1960, and it was opened in July 1967 by Princess Alexandra. Unlike other reservoirs in Northern England that are flooded valleys with a dam head, Derwent was dug out of the ground and the earth removed was used in its dam head.
The flow of the River Derwent can be supplemented, when necessary, by water transferred from the much larger Kielder Water in Northumberland. However, this connection cannot be used to increase the depth of the reservoir itself.
Sediment within the reservoir has been found to contain elevated levels of zinc, lead and cadmium. These have drained into the reservoir from areas of historic mining activity around Blanchland. Consequently, populations of macroscopic plants in the reservoir are relatively low.
Derwent Reservoir also hosts a sailing club, which holds many events throughout the year, including windsurfing, sailing, running and triathlons. The area around the reservoir hosts the annual Tour of the Reservoir cycle race.
The reservoir also has hydro electric plant installed, with a rating of 97 kilowatts.
# Brzeźno, Tczew County

Brzeźno is a settlement in the administrative district of Gmina Morzeszczyn, within Tczew County, Pomeranian Voivodeship, in northern Poland. It lies approximately 7 kilometres (4 mi) west of Morzeszczyn, 29 km (18 mi) south of Tczew, and 57 km (35 mi) south of the regional capital Gdańsk.
For details of the history of the region, see History of Pomerania.
# Wrestling World 2001

Wrestling World 2001 was a professional wrestling event produced by New Japan Pro-Wrestling (NJPW). It took place on January 4 in the Tokyo Dome. It was the tenth January 4 Tokyo Dome Show held by NJPW. The show drew 52,000 spectators.
The focal point of Wrestling World 2001 was a tournament to crown a new IWGP Heavyweight Champion, which accounted for five of the nine matches on the show. No other championships were defended in 2001, marking the first year that only one title was on the line. The show saw Toshiaki Kawada wrestle twice; Kawada had previously been one of the main event wrestlers of NJPW's biggest rival All Japan Pro Wrestling.

## Production
### Background

The January 4 Tokyo Dome Show is NJPW's biggest annual event and has been called "the largest professional wrestling show in the world outside of the United States" and the "Japanese equivalent to the Super Bowl".

### Storylines

Wrestling World 2001 featured professional wrestling matches that involved different wrestlers from pre-existing scripted feuds and storylines. Wrestlers portrayed villains, heroes, or less distinguishable characters in scripted events that built tension and culminated in a wrestling match or series of matches.

## Results

| No. | Results | Stipulations | Times |
| 1 | Kensuke Sasaki defeated Satoshi Kojima | Singles match: IWGP Heavyweight Championship tournament quarter-final | 16:33 |
| 2 | Hiroyoshi Tenzan defeated Yuji Nagata | Singles match: IWGP Heavyweight Championship tournament quarter-final | 16:45 |
| 3 | Koji Kanemoto and Minoru Tanaka defeated Shinya Makabe and Tatsuhito Takaiwa | Tag team match | 18:02 |
| 4 | Takashi Iizuka defeated Kendo Kashin | Singles match | 06:12 |
| 5 | Kensuke Sasaki defeated Masahiro Chono | Singles match: IWGP Heavyweight Championship tournament semi-final | 11:28 |
| 6 | Toshiaki Kawada defeated Hiroyoshi Tenzan | Singles match: IWGP Heavyweight Championship tournament semi-final | 10:45 |
| 7 | Keiji Mutoh and Shinjiro Otani defeated Jushin Thunder Liger and Manabu Nakanishi | Tag team match | 05:44 |
| 8 | Riki Choshu vs. Shinya Hashimoto ended in a no contest | Singles match | 15:20 |
| 9 | Kensuke Sasaki defeated Toshiaki Kawada | Singles match: IWGP Heavyweight Championship tournament final | 10:30 |

### IWGP Heavyweight Championship tournament bracket

| Quarterfinals | Quarterfinals | Semifinals | Semifinals | Finals | Finals |
| Satoshi Kojima | Sub | | | | |
| Kensuke Sasaki | 16:33 | | | | |
| Kensuke Sasaki | 16:33 | Kensuke Sasaki | Sub | | |
| | | Masahiro Chono | 11:28 | | |
| | | | | Kensuke Sasaki | Pin |
| | | | | Toshiaki Kawada | 10:30 |
| Yuji Nagata | Pin | | | | | Toshiaki Kawada | 10:30 |
| Hiroyoshi Tenzan | 16:45 | | | | |
| Hiroyoshi Tenzan | 16:45 | Hiroyoshi Tenzan | Pin | | |
| | | Toshiaki Kawada | 10:45 | | |
# Bryne Odhiambo

Bryne Odhiambo Omondi is a Kenyan goalkeeper currently in the ranks of Kenyan Premier League side Bandari, and the Kenya national football team.
Bryne formerly turned out for Tusker F.C. Agro Chemicals, Posta Rangers, Mathare United, and KCB before joining Bandari.
He made his Kenya national team debut in June 2023 in an international friendly against Pakistan in Cote D’or National Sports Complex, Mauritius.
# Emma Norsgaard

Emma Cecilie Norsgaard Bjerg née Jørgensen (born 26 July 1999) is a Danish cyclist, who currently rides for UCI Women's WorldTeam Movistar Team. Her major victories include winning stage six of the 2021 Giro Rosa (now called the Giro Donne) and stage six of the 2023 Tour de France Femmes.

## Personal life

Her brother Mathias Norsgaard is also a professional cyclist, with the Movistar Team. Norsgaard married cyclist Mikkel Bjerg in 2021.

## Major results
### 2015

    3rd Overall Rás na mBan
       1st Young rider classification
       1st Stage 2

### 2016

    1st Road race, National Road Championships
    6th Road race, UCI Junior Road World Championships

### 2017

    1st Time trial, National Junior Road Championships
    2nd Road race, UCI Junior Road World Championships
    UEC European Junior Road Championships
       2nd Road race
       3rd Time trial
    3rd Overall Energiewacht Tour Juniors

### 2018

    2nd Road race, National Road Championships

### 2020

    1st Road race, National Road Championships
    1st Stage 1 Setmana Ciclista Valenciana
    3rd Omloop van het Hageland

### 2021

    1st Time trial, National Road Championships
    1st Overall Festival Elsy Jacobs
       1st Points classification
       1st Young rider classification
       1st Stages 1 & 2
    1st Stage 6 Giro Rosa
    2nd Omloop Het Nieuwsblad
    2nd Le Samyn
    2nd Scheldeprijs
    3rd Overall Healthy Ageing Tour
       1st Young rider classification
    3rd Overall Thüringen Ladies Tour
       1st Young rider classification
       1st Stage 1
    6th Paris–Roubaix
    8th Nokere Koerse
    9th Gent–Wevelgem

### 2022

    1st Le Samyn
    2nd Omloop van het Hageland
    5th Gent–Wevelgem
    6th Omloop Het Nieuwsblad
    6th Classic Brugge–De Panne

### 2023

    1st Time trial, National Road Championships
    1st National Gravel Championships
    1st Stage 6 Tour de France
    2nd Overall Baloise Ladies Tour
    2nd Costa De Almería
    4th Omloop Het Nieuwsblad

### 2024

    National Road Championships
       1st Time trial
       3rd Road race
    UCI Gravel World Series
       1st Blaavands Huk
    2nd La Picto–Charentaise
    5th Omloop van het Hageland
    7th Classic Brugge–De Panne
    7th Nokere Koerse
# Niwki, Greater Poland Voivodeship

Niwki is a village in the administrative district of Gmina Chodów, within Koło County, Greater Poland Voivodeship, in west-central Poland. It lies approximately 4 kilometres (2 mi) north of Chodów, 28 km (17 mi) east of Koło, and 144 km (89 mi) east of the regional capital Poznań.
# Eosentomon asahi

Eosentomon asahi is a species of proturan that is in the family of Eosentomidae. It is largely found in Southern Asia.