# 2021 MUSC Health Women's Open

The second 2021 Charleston Open (branded as the MUSC Health Women's Open for commercial reasons) was a tournament on the 2021 WTA Tour. It was played on outdoor green clay courts in Daniel Island. It was held one day after the 48th edition ended and was a replacement tournament for other tournaments that were not held because of travel restrictions, and organised by Charleston Tennis with a single-year licence in 2021, held at Family Circle Tennis Center from April 12 to 18, 2021.

## Champions
### Singles

* Astra Sharma def. Ons Jabeur, 2–6, 7–5, 6–1

### Doubles

* Hailey Baptiste / Caty McNally def. Ellen Perez / Storm Sanders, 6–7$^{(4–7)}$, 6–4, [10–6]

## Singles main-draw entrants
### Seeds

| Country | Player | Rank$^1$ | Seed |
| TUN | Ons Jabeur | 28 | 1 |
| POL | Magda Linette | 51 | 2 |
| USA | Shelby Rogers | 52 | 3 |
| FRA | Alizé Cornet | 59 | 4 |
| JPN | Misaki Doi | 77 | 5 |
| AUS | Ajla Tomljanović | 78 | 6 |
| USA | Lauren Davis | 79 | 7 |
| USA | Madison Brengle | 81 | 8 |
* $^1$ Rankings are as of April 5, 2021

### Other entrants

The following players received wildcards into the main draw:
* Linda Fruhvirtová
* Emma Navarro
* CoCo Vandeweghe
The following player received entry as a special exempt:
* Camila Osorio
The following players received entry from the qualifying draw:
* Claire Liu
* Grace Min
* Alycia Parks
* Storm Sanders

### Withdrawals
#### Before the tournament

* Amanda Anisimova → replaced by Caty McNally
* Irina-Camelia Begu → replaced by Wang Yafan
* Anna Blinkova → replaced by Liudmila Samsonova
* Danielle Collins → replaced by Francesca Di Lorenzo
* Coco Gauff → replaced by Viktoriya Tomova
* Madison Keys → replaced by Sara Errani
* Barbora Krejčíková → replaced by Tereza Martincová
* Ann Li → replaced by Danka Kovinić
* Jessica Pegula → replaced by Clara Tauson
* Rebecca Peterson → replaced by Christina McHale
* Yulia Putintseva → replaced by Renata Zarazúa
* Anastasia Potapova → replaced by Stefanie Vögele
* Laura Siegemund → replaced by Kristie Ahn
* Sloane Stephens → replaced by Natalia Vikhlyantseva

### Retirements

* Alizé Cornet
* Misaki Doi
* Tereza Martincová

## Doubles main-draw entrants
### Seeds

| Country | Player | Country | Player | Rank$^1$ | Seed |
| AUS | Ellen Perez | AUS | Storm Sanders | 117 | 1 |
| USA | Kaitlyn Christian | USA | Sabrina Santamaria | 123 | 2 |
| JPN | Misaki Doi | JPN | Nao Hibino | 158 | 3 |
| AUS | Arina Rodionova | NED | Rosalie van der Hoek | 167 | 4 |
* Rankings are as of April 5, 2021.

### Other entrants

The following pair received a wildcard into the doubles main draw:
* Sophie Chang / Emma Navarro
The following pair received entry into the doubles main draw using a protected ranking:
* Oksana Kalashnikova / Alla Kudryavtseva
The following pair received entry into the doubles main draw as an alternate:
* Linda Fruhvirtová / Tereza Martincová

### Withdrawals
#### Before the tournament

* Anna Blinkova / Lucie Hradecká → replaced by Elixane Lechemia / Ingrid Neel
* Misaki Doi / Nao Hibino → replaced by Linda Fruhvirtová / Tereza Martincová
* Coco Gauff / Caty McNally → replaced by Beatrice Gumulya / Jessy Rompies
* Makoto Ninomiya / Yang Zhaoxuan → replaced by Jamie Loeb / Erin Routliffe

#### During the tournament

* Linda Fruhvirtová / Tereza Martincová

### Retirements

* Arina Rodionova / Rosalie van der Hoek