OpenLLM-France/wikimedia huggingface dataset:
# Agent study

An agent study is a part of a clinical trial that tests the chemotherapeutic properties of a specific substance. More specifically, an agent study is used to detect whether or not a substance can prevent or inhibit cancer. In a clinical trial, researchers perform multiple studies in order to test the potential of new cancer drugs. An agent study helps determine the potential of a substance to inhibit cancer, before more studies are done in order to further knowledge of this potential.

## Cytotoxic vs. Cytostatic Agents

Agent studies are used to determine whether a substance exhibits cytotoxicity or cytostasis. A cytotoxic agent will shrink a tumor, while, a cytostatic agent slows or stops tumor growth and metastases. It is important to determine which of these effects an agent poses so that a proper clinical trial can be designed. For example, a study with a cytotoxic agent will look for tumor shrinkage vs. dose. It is much harder to develop a clinical trial for a cytostatic agent.

## Phase I Clinical Trials

Phase I trials are used to determine the maximum tolerated dose of an agent. This dose is then used in the Phase II trials. Maximum tolerated dose is based on the measured toxicity in cytotoxic agents. Cytostatic agents have been demonstrated to show biologic effects while also being nontoxic. It is recommended that cytostatic agent trials determine toxicity as well as evaluation of a biologic end point in response to different doses.
Synonym: Chemoprevention study
# Tisis frimensis

Tisis frimensis is a moth in the family Lecithoceridae. It was described by Kyu-Tek Park in 2005. It is found on Sabah in Malaysia.
# Lowville, Wisconsin

Lowville is a town in Columbia County, Wisconsin, United States. The population was 987 at the 2000 census.

## History

When the county was organized in 1846, survey Township 10, Range 10; the south half of Township 1, Range 10; and the east half of Township 10, Range 9, were made into a voting precinct under the name of Lowville, after local pioneer Jacob Low. In January 1849, the county board designated Townships 10 and 11 of Range 10, and the east half of Township 10, Range 9, as a new civil town, given the same name of Lowville, and Low's home was designated as the voting place for the town's first election. At a meeting of the County Board of Supervisors on January 8, 1850, the town of Lowville was reduced to just Township 11, Range 10.

## Geography

According to the United States Census Bureau, the town has a total area of 35.7 square miles (92.5 km$^2$), of which, 34.3 square miles (88.7 km$^2$) is land and 1.5 square miles (3.8 km$^2$) is water. The total area is 4.11% water.

## Demographics

As of the census of 2000, there were 987 people, 368 households, and 294 families residing in the town. The population density was 28.8 people per square mile (11.1/km$^2$). There were 394 housing units at an average density of 11.5 per square mile (4.4/km$^2$). The racial makeup of the town was 97.97% White, 0% African American, 0.41% Native American, 0.91% Asian, 0% Pacific Islander, 0% from other races, and 0.71% from two or more races. 0.61% of the population were Hispanic or Latino of any race.
There were 368 households, out of which 29.3% had children under the age of 18 living with them, 71.7% were married couples living together, 4.9% had a female householder with no husband present, and 20.1% were non-families. 17.1% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older. The average household size was 2.68 and the average family size was 2.99.
In the town, the population was spread out, with 23.5% under the age of 18, 6.4% from 18 to 24, 28.4% from 25 to 44, 29.1% from 45 to 64, and 12.7% who were 65 years of age or older. The median age was 41 years. For every 100 females, there were 105.2 males. For every 100 females age 18 and over, there were 103.5 males.
The median income for a household in the town was $54,519, and the median income for a family was $57,500. Males had a median income of $35,515 versus $27,300 for females. The per capita income for the town was $20,039. 3.8% of the population and 3% of families were below the poverty line. Out of the total population, 4.4% of those under the age of 18 and 6.5% of those 65 and older were living below the poverty line.
# M8 road (Malawi)

The M8 road is the road in Malawi that serves as an east–west connector in southern Malawi, bridging the gap between the major routes M1 and M3. Spanning 35 kilometers, the road links the towns of Balaka and Liwonde, facilitating efficient travel and trade between the region's important population centers and economic hubs.

## History

During the British colonial era, the M8 played a role as a connection, largely due to Zomba's strategic location as the traditional capital of Malawi, situated further east. The road's significance was likely recognized early on, and it may have been upgraded with pavement as far back as the 1950s, underscoring its importance in facilitating communication and commerce between key administrative centers and population hubs.

## Route

The M8 serves as a link between the M1 and M3, two major routes in Malawi, connecting the western and eastern regions. Balaka stands as the principal town along this route, which terminates just west of Liwonde. Notably, the entire 35-kilometer stretch is paved, ensuring a smooth journey through the countryside, characterized by rolling hills and a moderate elevation of around 600 meters, dotted with clusters of settlements and villages.
# Jacque

Jacque is a given name and a surname which may refer to:

## People

* Jacque Batt (died 2014), American First Lady of Idaho 1994-1999
* Jaque Fourie (born 1983), South African former rugby union rugby player
* Jacque Fresco (1916–2017), American futurist and self-described social engineer
* Jacque Jack Jenkins (American football) (1921-1982), American football player
* Jacque Jones (born 1975), American Major League Baseball assistant hitting coach and former player
* Jacque LaPrarie, American college football player in the early 1980s
* Jacque MacKinnon (1938-1975), American League Football and National League Football player
* Jacquelyn Jacque Mercer (1931-1982), winner of the Miss America beauty pageant in 1949
* Jacqueline Jacque Reid (born 1975), American television and radio host, journalist and former news anchor
* Jacque Robinson (born 1963), American football player
* Jacque Vaughn (born 1975), American National Basketball Association assistant coach and former player
* Andre Jacque (born 1980), American politician
* Charles Jacque (1813–1894), French painter of animals and engraver
* Olivier Jacque (born 1973), French former Grand Prix motorcycle road racer

## Fictional characters

* the title character of the 1772 Daniel Defoe novel Colonel Jack, also spelled Jacque
# Ticheville

Ticheville (French pronunciation:) is a commune in the Orne department in north-western France.

## Geography

The commune is made up of the following collection of villages and hamlets, Le Bocage and Ticheville.
The commune along with another 11 communes shares part of a 1,400 hectare, Natura 2000 conservation area, called the Haute Vallée de la Touques et affluents.
The commune has the Touques flowing through its borders, plus four other streams, La Roulandiere, The Pres Garreaux, The Tanneries and The Valame.
vteNeighbouring communes :
Vimoutiers
Pontchardon
Guerquesalles
Ticheville
Le Bosc-Renoult
Roiville
Sap-en-Auge :

## Places of interest

Ticheville is home to Haras du Mezeray, a Thoroughbred racehorse breeding farm founded by Paul de Moussac in 1962.

### National heritage sites

Priory of Ticheville is a former 14th centuayy priory that was listed as a Monument historique in 1994.
* Priory Chapelle
* Saint-Pierre Church in Ticheville

## Notable people

* Jean Baptiste Boisduval (1799 – 1879), a French lepidopterist, botanist, and physician was born here.
# Maps (manga)

Maps (マップス) is a Japanese manga series written and illustrated by Yuichi Hasegawa. It was serialized in the Gakken magazine Monthly Comic Nora from 1985 to 1994. The series was adapted into two anime original video animations (OVAs): the 1987 original, fully titled Maps: Densetsu no Samayoeru Seijintachi (マップス 伝説のさまよえる星人たち, lit. "Maps: Legendary Space Wanderers") in Japan, and the 1994 remake, simply titled Maps.

## Plot

Maps follows a normal Earth boy named Gen. He and his girlfriend Hoshimi meet Lipmira, a woman from outer space, who tells Gen that he is the "mapman", meaning the map to a great treasure is coded in his genes. Gen and Hoshimi leave Earth with Lipmira to find the treasure, a quest shared by evil space people whom they are often compelled to fight against. Notable aspects of the series are the spaceships (which look like giant silver angelic women, often described as "hood ornaments") and the robot women that control them, or more precisely embody them for dealings with regular-sized life forms (Lipmira is one of these robot embodiments). Each ship and its pilot have a distinct character, from playful to evil.

## Media
### Manga

Maps was written and illustrated by Yuichi Hasegawa. It was serialized in the Gakken magazine Monthly Comic Nora from 1985 to 1994. A total of 17 tankōbon bound volumes were published in Japan between 1987 and 1995. Japan Media Factory re-released the manga in bunkoban format in 2003.

### OVAs

Two OVAs based on Maps have been created. The first, Maps: Densetsu no Samayoeru Seijintachi, was produced by Studio Gallop, directed by Keiji Hayakawa, written by Kenji Terada, and musically scored by Kohei Tanaka. It was released exclusively in Japan on July 17, 1987. The second, simply titled Maps, was animated by TMS Entertainment, directed by Susumu Nishizawa, written by Masaki Tsuji, and musically scored by Masahiro Kawasaki. It was released in Japan in four episodes split into two volumes on July 8, 1994 and February 24, 1995. An English version of this OVA was later licensed by ADV Films and distributed in North America.

#### 1994-1995 OVA episodes

* Galactic Angel (ACT1 宇宙（あま）翔ける天使, Act 1: Ama Kakeru Tenshi)
* A Reward for the Travelers (ACT2 トラベラーの報酬, Act 2: Traveller no Hōshū)
* Six Ghost Ships (ACT3 六人の幽霊船, Act 3: Rokunin no Yūreisen)
* Revival of the Legend (ACT4 伝説の復活, Act 4: Densetsu no Fukkatsu)
# National Hockey Super League

The National Hockey Super League (NHSL) is a defunct professional ice hockey league based in Australia. Started in November 2021, it was the first professional ice hockey league in Australia.
The league was formally announced on the 16th of September, with three founding teams to start the league. All three teams were based in Adelaide, and all games were played in the IceArenA. The 2022-2023 season did not go ahead nor has there been any official announcements about the league since 2022.

## Teams

| Team | City | Arena | Capacity | Founded | Joined |
| National Hockey Super League ||||||||
| Adelaide Xtream | Adelaide | IceArenA | 1,500 | 2021 | 2021 |
| Noarlunga Stars | Adelaide | IceArenA | 1,500 | 2021 | 2021 |
| Port Adelaide Brewers | Adelaide | IceArenA | 1,500 | 2021 | 2021 |

## Expansion

In its first year, NHSL features three teams made up of predominantly South Australian-based players. The league had plans to expand to a national format in 2022, with the goal to have 15 teams nationwide by 2023. The planned 2022-2023 season did not go ahead, nor has there been any posts on the official Instagram page since August 19, 2022. The official website is defunct, leading to speculation that the league has folded.
| Team | City | Arena | Capacity | Founded | Joined |
| Possible Expansion ||||||||
| Cockburn Chiefs | Cockburn | Cockburn IceArena | 1,500 | 2022 | 2022 |
| Fremantle Fury | Fremantle | Cockburn IceArena | 1,500 | 2022 | 2022 |
| Perth Patriots | Perth | Perth Ice Arena | 1,500 | 2022 | 2022 |
# Martretia

Martretia is a genus of plants in the family Phyllanthaceae first described as a genus in 1907. It contains only one known species, Martretia quadricornis, native to western and central Africa from Sierra Leone to Zaire. It is dioecious, with male and female flowers on separate plants.
# Hydroxymethylphenol

Hydroxymethylphenol may refer to:
* Gastrodigenin (4-hydroxymethylphenol)
* Salicyl alcohol (2-hydroxymethylphenol)
# Luis F. Cruz

Luis F. Cruz Batista is a certified public accountant and the current director of the Puerto Rico Office of Management and Budget (OGP in Spanish). Before his appointment Cruz served as director of the Commission on Treasury and Budget of the 29th House of Representatives. He had also run his own private accounting firm since 1994 and had previously offered consulting services to OGP as a private consultant.
Academically, Cruz possesses a bachelor's degree in accounting from the University of Puerto Rico and a master's degree from the Interamerican University of Puerto Rico.
# Tisis helioclina

Tisis helioclina is a moth in the family Lecithoceridae. It was described by Edward Meyrick in 1894. It is found in Myanmar.
The wingspan is 20–22 mm. The forewings are bright orange with a dark leaden-metallic streak along the inner margin from one-fourth to the base, then along the costa to one-third, where it crosses the wing in a rather strong curve to the middle of the inner margin. There is a large bronzy-purplish-fuscous patch occupying the apical area, its anterior edge forming a very strong rounded angulation which reaches to the middle of the wing. The hindwings are rather dark purplish fuscous.
# 2007 Tour of Qatar

The 2007 Tour of Qatar was held from 28 January to 2 February 2007 in Qatar. It was a multiple stage road cycling race that took part over six stages with a total of 715.5 kilometres and is part of the 2006–2007 UCI Asia Tour.

## Stage summary

| Stage | Date | Start | Finish | Distance | Stage Top 3 | Leading Top 3 | Time |
| 1 | 28 January | Doha Corniche | Doha Corniche | 6 km | Quick-Step–Innergetic Team Milram Liquigas | Steven de Jongh Wilfried Cretskens Tom Boonen | 6:33 + 0:00 + 0:00 |
| 2 | 29 January | Al Wakra | Qatar Olympic Committee | 135.5 km | Tom Boonen Alessandro Petacchi Jean-Patrick Nazon | Tom Boonen Steven de Jongh Gert Steegmans | 3:08:13 + 0:07 + 0:08 |
| 3 | 30 January | Dohat Salwa | Khalifa Stadium | 140 km | Tom Boonen Alessandro Petacchi Bernhard Eisel | Tom Boonen Alessandro Petacchi Steven de Jongh | 6:33.09 + 0:13 + 0:17 |
| 4 | 31 January | Camel Race Track | Doha Golf Club | 139.5 km | Tom Boonen Graeme Brown Murilo Fischer | Tom Boonen Steven de Jongh Bernhard Eisel | 9:27.52 + 0:27 + 0:33 |
| 5 | 1 February | Al Zubarah | Mesaieed | 160.5 km | Greg Van Avermaet Marcel Sieberg Stéphane Poulhies | Wilfried Cretskens Tom Boonen Steven de Jongh | 12:54:41 + 2:19 + 2:44 |
| 6 | 2 February | Sealine Beach Resort | Doha Corniche | 134 km | Tom Boonen Alessandro Petacchi Graeme Brown | Wilfried Cretskens Tom Boonen Steven de Jongh | 15:50:58 + 2:09 + 2:44 |

## Other leading top threes

| Stage | Sprints | Pts | Under 23 | Time | Teams | Time |
| 1 | no sprints | none | Marcel Sieberg Francesco Failli Wim De Vocht | 6:38 + 0:02 + 0:04 | Quick-Step–Innergetic Team Milram Liquigas | 6:33 + 0:05 + 0:07 |
| 2 | Tom Boonen Alessandro Petacchi Jean-Patrick Nazon | 30 27 25 | Marcel Sieberg Francesco Failli Nick Ingels | 3:08:28 + 0:02 + 0:04 | Quick-Step–Innergetic Team Milram Liquigas | 9:12:03 + 0:05 + 0:07 |
| 3 | Tom Boonen Alessandro Petacchi Aurélien Clerc | 60 54 42 | Nick Ingels Lloyd Mondory Francesco Failli | 6:33:38 + 0:02 + 0:03 | Quick-Step–Innergetic Predictor–Lotto Team Milram | 19:27:26 + 0:04 + 0:05 |
| 4 | Tom Boonen Alessandro Petacchi Bernhard Eisel | 91 54 47 | Lloyd Mondory Francisco Ventoso Alexandre Pichot | 9:28:29 + 0:08 + 0:15 | Quick-Step–Innergetic T-Mobile Team Rabobank | 28:12:08 + 0:06 + 0:19 |
| 5 | Tom Boonen Alessandro Petacchi Bernhard Eisel | 92 54 51 | Alexandre Pichot Lloyd Mondory Francisco Ventoso | 12:57:52 + 0:53 + 0:58 | Quick-Step–Innergetic T-Mobile Team Rabobank | 38:36:35 + 0:06 + 4:31 |
| 6 | Tom Boonen Alessandro Petacchi Lloyd Mondory | 122 81 60 | Alexandre Pichot Lloyd Mondory Francisco Ventoso | 15:54:09 + 0:53 + 0:58 | Quick-Step–Innergetic T-Mobile Team Rabobank | 47:25:26 + 0:06 + 4:31 |

### Men's top 10 overall

| Pos | Rider | Time |
| 1 | Wilfried Cretskens | 15:50:58 |
| 2 | Tom Boonen | + 2:09 |
| 3 | Steven de Jongh | + 2:44 |
| 4 | Bernhard Eisel | + 2:52 |
| 5 | Greg Henderson | + 3:01 |
| 6 | Andreas Klier | + 3:08 |
| 7 | Leif Hoste | + 3:09 |
| 8 | Alexandre Pichot | + 3:11 |
| 9 | Mathew Hayman | + 3:30 |
| 10 | Servais Knaven | + 3:44 |
# The Evolution of Gospel

Professional ratings :
| Review scores ||
| Source | Rating |
| AllMusic | |
| Calgary Herald | B |
The Evolution of Gospel is the debut studio album by Sounds of Blackness, released in 1991. In 1992, the album received the Grammy Award for "Best Gospel Choir or Chorus Album".

## Track listing

| # | Title | Length | Composer(s) | Producer(s) | Lead Vocalist(s) |
| 1 | "Chains" | 1:02 | Gary Hines | Gary Hines | Carrie Harrington |
| 2 | "Optimistic" | 5:19 | Gary Hines, Jimmy Jam, Terry Lewis | Gary Hines, Jimmy Jam, Terry Lewis | Ann Bennett-Nesby, Carrie Harrington, Coré Cotton, Patricia Lacy, Jamecia Bennett |
| 3 | "Ah Been Workin' " | 0:42 | Gary Hines | Gary Hines | Dorothy J. Townes |
| 4 | "The Pressure Pt. 1" | 6:04 | Gary Hines, Jimmy Jam, Terry Lewis | Gary Hines, Jimmy Jam, Terry Lewis | Ann Bennett-Nesby |
| 5 | "Testify" | 4:58 | Gary Hines, Jimmy Jam, Terry Lewis | Gary Hines, Jimmy Jam, Terry Lewis | Ann Bennett-Nesby, Andre Shepard |
| 6 | "Gonna Be Free One Day" | 0:37 | Gary Hines | Gary Hines | Otis Montgomery |
| 7 | "Stand" | 4:25 | Sylvester "Sly Stone" Stewart | Gary Hines | Ann Bennett-Nesby, Prof. T |
| 8 | "The Pressure Pt. 2" | 5:42 | Gary Hines, Jimmy Jam, Terry Lewis | Gary Hines, Jimmy Jam, Terry Lewis | Ann Bennett-Nesby |
| 9 | "Your Wish is My Command" | 5:01 | Tim Wortham, Gary Hines, Tony Haynes | Gary Hines | Ann Bennett-Nesby |
| 10 | "Hallelujah Lord!" | 1:44 | Carrie Harrington, Gary Hines | Gary Hines | |
| 11 | "We Give You Thanks" | 6:16 | Gary Hines | Gary Hines | Ann Bennett-Nesby |
| 12 | "He Holds the Future" | 5:01 | Gary Hines | Gary Hines | Ann Bennett-Nesby, Carrie Harrington, Prof. T |
| 13 | "What Shall I Call Him?" | 4:04 | Gary Hines | Gary Hines | Ann Bennett-Nesby, Patricia Lacy, Elizabeth J. Turner |
| 14 | "Better Watch Your Behavior" | 1:54 | Gary Hines | Gary Hines | |
| 15 | "Please Take My Hand" | 4:37 | Gary Hines | Gary Hines | Ann Bennett-Nesby |
| 16 | "I'll Fly Away" | 3:49 | Albert E. Brumley | Gary Hines | Shirley Marie Graham |
| 17 | "Harambee (Swahili for 'Let Us All Pull Together')" | 1:04 | Gary Hines | Gary Hines | |

## Chart positions
### Album

| Year | Chart | Peak |
| 1991 | The Billboard 200 | #176 |
| 1991 | Top Gospel Albums | #12 |
| 1991 | Top R&B Albums | #4 |

### Singles
#### "Optimistic"

| Year | Chart | Peak |
| 1991 | Dance Music/Club Play Singles | #17 |
| 1991 | Hot Dance Music Maxi-Singles Sales | #17 |
| 1991 | Hot R&B/Hip-Hop Singles & Tracks | #3 |

#### "The Pressure Pt. 1"

| Year | Chart | Peak |
| 1991 | Dance Music/Club Play Singles | #1 |
| 1991 | Hot Dance Music Maxi-Singles Sales | #3 |
| 1991 | Hot R&B/Hip-Hop Singles & Tracks | #17 |

#### "Testify"

| Year | Chart | Peak |
| 1992 | Dance Music/Club Play Singles | #7 |
| 1992 | Hot Dance Music Maxi-Singles Sales | #14 |
| 1992 | Hot R&B/Hip-Hop Singles & Tracks | #12 |
# Tichilești, Tulcea

Tichilești is a leper colony in Isaccea, Tulcea County, Romania, having 9 inhabitants in 2019. Although officially a hospital, Tichilești appears to be more like a small village, and is formally administered as a village by Isaccea. Tichilești was founded as a monastery, in 1875 becoming a leper colony.

## Name

Tichilești's name is derived from the Turkish name of the settlement, Tekeli is derived from the Turkish word teke, meaning "he-goat".

## History

Tichilești was founded as a monastery, in 1875 becoming a leper colony. A legend says the monastery was founded by one of the Cantacuzino princesses who was affected by leprosy. Another theory of the history the settlement is that a group of Russian refugees (see Lipovans) settled there and founded the monastery, but soon became outlaws who were eventually caught.
In 1918, for unknown reasons, a part of the lepers moved to Largeanca, near the Bessarabian town of Ismail, while the rest of them being allegedly killed and their bodies being burned or thrown in a lime pit.
Following a 1926 newspaper article by F. Brunea-Fox, a journalist who lived with the lepers for three weeks, a hospital was built in 1928 at the monastery. The houses and the central courtyard were built in the 1930s.
In July 1932, a group of 25 starving lepers from Tichilești threatened to march to Bucharest and entered the town of Isaccea demanding food. Local grocers and farmers had stopped supplying them food because the government had not been providing funding. The Isacceans barred their houses until the military escorted the lepers back to their colony.
Initially, the lepers were not allowed to leave the colony. This changed in 1991, but many residents, who had lived most of their lives in the colony, continued living there.
European Union funds came to Tichilești in the decade following the year 2000, and they were able to install bathrooms, refrigerators, and satellite television, and to put air-conditioners in the canteen.

## Demographics

The last case of leprosy in Romania was diagnosed in 1981 and the age of the patients in Tichilești in 2002 ranged between 37 and 90, most of them having an age of more than 60 years. In Tichilești there are two churches, an Orthodox one and a Baptist one. A cure for leprosy has been known for a long time, however the disease was too advanced for these people who live in Tichilești. As a result they were not cured but it made it no longer contagious. As of 2023 there are still nine people living at the colony, most of whom are very elderly.

### Population

* 1930: 200
* 1998: 39
* 2002: 22
* 2011: 19
* 2017: 10
* 2019: 9
* 2023: 9
# Nios

Nios or NIOS may refer to:

## Places

* Ios or Nios, a Greek island

## Computing

* Network I/O System, Digital Research's NIOS component in CP/NET in the 1980s
* NetWare I/O Subsystem, Novell's NIOS component in the 32-bit network clients in the mid-1990s
* Nios embedded processor, Altera 16-bit embedded processor
** Nios II, Altera 32-bit embedded processor

## Other uses

* National Institute of Open Schooling, the board of education in India
* Hyundai Grand i10 Nios, a 2019–present Korean-Indian city car
# Tisis imperatrix

Tisis imperatrix is a moth in the family Lecithoceridae. It was described by Edward Meyrick in 1910. It is found on Borneo.
The wingspan is about 20 mm. The forewings are bright deep coppery purple, with strong indigo-blue reflections. The hindwings are dark purple fuscous.
# Title 44 of the Code of Federal Regulations

CFR Title 44 – Emergency Management and Assistance is one of 50 titles in the United States Code of Federal Regulations (CFR). Title 44 is the principal set of rules and regulations issued by federal agencies of the United States regarding emergency management and assistance.

## Structure

The table of contents, as reflected in the e-CFR updated February 19, 2014, is as follows:
| Volume | Chapter | Parts | Regulatory Entity |
| 1 | I | 0-399 | Federal Emergency Management Agency, Department of Homeland Security |
| | IV | 400-499 | Department of Commerce and Department of Transportation |