# List of Doctors characters introduced in 2021

Doctors is a British medical soap opera which began broadcasting on BBC One on 26 March 2000. Set in the fictional West Midlands town of Letherbridge, the soap follows the lives of the staff and patients of the Mill Health Centre, a fictional NHS doctor's surgery, as well as its sister surgery located at a nearby university campus. The following is a list of characters that first appeared in Doctors in 2021, by order of first appearance. All characters are introduced by the programme's executive producer, Mike Hobson. Luca McIntyre (Ross McLaren) made his debut in February as a nurse at the Mill. In March, PPG chairwoman Miranda Evans (Ruthie Henshall) began appearing. Harriet Shelton (Carley Stenson) then joined in April. Lucy Benjamin appeared in May as Jan Fisher in a standalone episode. In September, Angela Wynter joined the cast as Makeda, the mother of Bear Sylvester (Dex Lee). Kevwe Emefe made her debut as Chelle Henry, a patient of Ruhma Carter's (Bharti Patel), in December. Additionally, multiple other characters appear throughout the year.

## Luca McIntyre

Luca McIntyre, portrayed by Ross McLaren, made his first appearance on 24 February 2021. He was introduced following the departure of nurse Ayesha Lee (Laura Rollins) the year prior. McLaren's acting credits confirmed that he had been contracted as a series regular on the soap and he felt thrilled to be cast on Doctors. McIntyre described Luca as a cheeky and lovely character who would "go the extra mile" to help a patient. Luca's introduction sees him feature in a standalone centric episode that explores his background, including experiencing homophobia in his former workplace and suffering a car accident that ends the life of his boyfriend Billy Parker (Daniel Cornish). His background also involves a religious upbringing and a bad relationship with his mother, and later scenes in the series reveal that Luca is HIV-positive, which he initially receives a negative response to from patients of the Mill Health Centre.
Since his introduction, Luca has developed a friendship with Emma Reid (Dido Miles), whom he later begins to live with. Jonno Parker (Tommy Sim'aan), the brother of his dead boyfriend, blackmails Luca in a storyline that eventually sees Luca helping Jonno to recover from his drug addiction. Luca's argumentative nature has also been explored, including his various disputes with surgery partners Zara Carmichael (Elisabeth Dermot Walsh) and Daniel Granger (Matthew Chambers). For his portrayal of the character, McLaren has been nominated for various awards at the National Television Awards, the Inside Soap Awards and the RTS Midlands Awards.

## Miranda Evans

Miranda Evans, portrayed by Ruthie Henshall, first appeared 25 March 2021 and made her final appearance on 22 April 2021. Details surrounding the character and casting were announced on 16 March 2021, with Simon Timblick of What's on TV writing that she is "the infamous new head of the Patient Participation Group" (PPG). He confirmed that the role would be recurring. Prior to her first appearance, she is mentioned by Bear Sylvester (Dex Lee) when he discovers that she is the chairwoman of the PPG. He learns that receptionist Valerie Pitman (Sarah Moyle) has worked with Miranda, and asks for intel on her. Valerie tells Bear that Miranda is "a terrible manager and a real bully". Bear accidentally reveals this to Miranda, who he believes is somebody attending the meeting like him.
Following the meeting, Bear invites her to visit the Mill to talk about her new patient consultation scheme. When Valerie meets her, she assumes that she her personality has changed since she saw her. Valerie gives Miranda a tuna sandwich, not knowing that she is allergic to fish. Afterwards, Miranda confronts Valerie in private and insults her. Miranda suggests going for lunch with Bear, where she flirts with him. Despite Bear not returning flirtatious energy, she continues to flirt with him, and whilst at the Mill, receptionist Karen Hollins (Jan Pearson) notices Miranda checking Bear out. She leaves Bear a voicemail telling him that she enjoyed the meal, and would like to go for cocktails with him. Miranda then sends Bear a "rather risque" GIF, but insists it is a joke. After Bear tells her that he is not interested in her romantically and wants a professional relationship with her, she dismisses him. Miranda then informs Valerie that she will never see her again.

## Harriet Shelton

Harriet Shelton, portrayed by Carley Stenson, first appeared on 28 April 2021 and made her final appearance on 28 September 2021. Harriet is introduced as a police sergeant at Letherbridge Police Station. Stenson began filming for the soap in February 2021, and she confirmed her casting on Instagram on 19 April 2021, where she expressed her gratitude to be appearing on Doctors. Stenson's followers expressed their excitement to see her in the soap, describing her as "the most beautiful policewoman" and stating that they will watch Doctors to see her.
Stenson said that the environment on set is "calm and welcoming" and that working with Walker is an "honour". Her friend, Ali Bastian, appeared in Doctors in 2019 as practice manager Becky Clarke. Bastian learned that Stenson would be in the soap and told her how "amazing" the cast and crew members were, which Stenson was glad to learn is true. Stenson said that since she is pregnant and due to the ongoing COVID-19 pandemic, it has been a challenge for her to find work. She described Harriet's storyline as "cracking", and noted that she was working amongst "highly experienced, impressive actors in such a positive place". Stenson confirmed that the role would be recurring, describing her experience on set as "such a fun journey" in April. In an interview with Inside Soap, Stenson stated that her character is determined and capable of performing her job well, and that she is "one of the lads". She said that viewers will see her "going from strength to strength" professionally, and that eventually, she forms a "camaraderie and trust" with Rob. She explained that Harriet has "worked her way up the ranks" to become a sergeant and is "massively determined" to succeed in the job role. Stenson also talked about the uniform she is required to wear as part of the role, stating that it hides her baby bump well. She likes wearing the police gear for the role and said that she enjoys playing a police officer, but joked that she would not be a good police officer in real life.
When she arrives at Letherbridge Police Station, Rob Hollins (Chris Walker) "doesn’t exactly give Harriet a warm welcome". Rob is unhappy about having to mentor Harriet, but they are thrown into working together when they are put on a case with each other. Since they do not initially get along, Harriet makes an effort to know Rob. She learns about Rob and wife Karen Hollins' (Jan Pearson) foster work, and when they get along, Rob invites her to a quiz night. Whilst on a crime scene, Rob pauses and Harriet is forced to cover for him; she asks why he blanked and he claims that it was a moment of old age. Rob later opens up to Harret, explaining that he suffers from post-traumatic stress disorder due to a traumatic event at work years ago. Harriet lends her support to Rob, stating she will always be there for him. When Harriet and Rob are chasing criminals Aaron Jeffries (Zak Douglas) and Lenny Calhoun (Nicholas Chambers), Harriet finds Rob standing over the body of Aaron, who is laying lifeless at the bottom of a staircase. She questions a clueless Rob on what happened and rushes to help Aaron. After Marvin Bulis (Philip Martin Brown) reveals that he saw the events, he gives a witness statement stating that Harriet pushed Aaron down the flight of stairs. She threatens Marvin to keep quiet, which is overseen by Valerie Pitman (Sarah Moyle); Valerie also gives a statement against Harriet. She is arrested and apologises to Rob, telling him that if not for the assault, she believes that the pair could have become romantic. After the scenes had aired, Stenson confirmed that her tenure on Doctors had come to an end due to being heavily pregnant whilst filming the scenes.

## Jan Fisher

Jan Fisher, portrayed by Lucy Benjamin, first appeared on 24 May 2021 in the episode "Three Consultations and a Funeral". Cast member Sarah Moyle recommended Benjamin for the role of Jan to producers. Benjamin's casting as Jan was announced a week prior to the airing of the episode by What to Watch journalist Alison Slade. Referring to her history of appearing on fellow BBC soap opera EastEnders as Lisa Fowler, Slade wrote that Benjamin had swapped "Walford for Letherbridge". Slade also revealed that it would be a self-contained standalone episode. Benjamin stated that she loved playing Jan for the episode and noted her enjoyment at getting to star alongside Dido Miles in the two-hander. She added that Miles was an amazing actress to work with. The three consultations Dr. Emma Reid (Miles) has with Jan that are shown in the episode are set over the timeframe of a month.
Jan has her first appointment with Emma where she tells Emma that she cannot sleep. Emma asks if she is stressed, but she is interrupted by Jan's husband Mark calling her. He demands to know where she is and apologises for being away from him. Emma asks about the phone call and Jan explains that they have just argued but takes the blame for their argument. Emma asks Jan questions about her life to get a clear idea about her inability to sleep, and when Emma asks if Jan is depressed, she avoids the question. Mark phones again and Jan lies about her whereabouts. Emma questions why she lied to Mark, and she reveals that Mark is having affairs, chooses her outfits and tracks her location, but she does not want to lose their relationship. Jan then demands sleeping pills, but Emma feels that they would not solve her problems. Weeks later, Jan arrives at Emma's office with an injury on her face, having been thrown out by Mark. She explains that she was trying to buy sleeping pills on his laptop and found his affair with a colleague, to which she confronted him. Jan recalls an earlier situation where Mark disappeared for a week, leaving her without money and food, and told her that he would only return if she stopped accusing him of having affairs and stopped interrupting him.
Jan explains to Emma that he has a high sex drive and has forced her to have sex with him, as well as having casual sex with numerous young women. Emma asks Jan a series of questions to get Jan to realise that she is a victim of domestic abuse, but she leaves after being offended by Emma's assumptions. Their third and final consultation is at the police station, where Emma works as a force medical examiner. Jan asks Emma if Mark knows of her whereabouts, but Emma reminds her that Mark is dead and that Jan has been arrested under suspicion of murdering him. She recalls to Emma that Mark demanded that she stays in the house for a month, but wanted to cook him a special dinner for their anniversary. He threw the dinner at her and forced her to pick it up, taunting her, and Jan attacked Mark with a carving knife. Emma tells Jan about her friend who was a victim of coercive control which leads Jan to realise that Mark abused her for 32 years.
"Three Consultations and a Funeral" won the RTS Midland Award in the Scripted category, as well as Benjamin winning the Acting Performance accolade for portraying Jan in the episode. The award marked Benjamin's first award in her 43-year-long career in the acting industry. The episode also won the award for Best Single Episode at the 2022 British Soap Awards. Following the win, the BBC transmitted a special repeat of the episode and confirmed that a follow-up episode featuring Jan's court trial was in production. The episode. "The Trials of Jan Fisher", aired in September 2022. Benjamin was pleased to be asked back to Doctors since she felt a responsibility to show the public what had happened to Jan, as well as being excited to work with the crew again. She revealed to magazines that the episodes would cover two separate trials; one which goes badly for Jan compared to a second and more favourable trial. As part of a toxic relationship storyline Benjamin did for EastEnders, she had visited women's refuges. She used the experiences and stories to aid her portrayal of Jan. She hoped that the ending would show the public and people in similar situations that there can be a positive ending to domestic abuse cases.

## Makeda Sylvester

Makeda Sylvester, portrayed by Angela Wynter, first appeared on 29 September 2021 and made her final appearance on 1 December 2021. Makeda was introduced as the mother of established character Bear Sylvester (Dex Lee). She has owned a Caribbean café since moving to Letherbridge but Bear suspects that there is an issue with the café. She explains to Bear that Clive Hopper (Jim Findley) has opened a rival Caribbean café in the area and that he has taken the majority of her customers. Bear gives her the idea of getting a mystery shopper to trial Clive's café and inform Makeda on what he is doing better than her, to which she asks Bear to perform the trial. Afterwards, Bear devises a plan to run Makeda's café as a mobile business. Makeda tells him that due to her age, she does not want to begin a new business venture and then announces her decision to move to France with Clive, with whom she has formed a romantic connection with. Whilst packing up the café, Makeda begins to suffer from fatigue and experiences pain. Bear sees her in pain and asks her to see a doctor, but Makeda refuses due to her previous doctor having retired and not wanting to see a new doctor due to the treatment of Black women by medical professionals.
Bear persuades Makeda to see his colleague, Zara Carmichael (Elisabeth Dermot Walsh), who he promises Makeda will treat her well. Zara informs Makeda that she needs a sigmoidoscopy and refers her to St. Phils Hospital for the procedure. Once there, Bear has to leave to take care of a task at the Mill. Makeda is seen by nurse Cathy Jenkins (Laura Bayston), who continuously mispronounces her name and speaks to her with an unkind attitude. Makeda stands up for herself and corrects Cathy on the pronunciation of her name. Cathy responds with a racist attitude and Makeda refuses to be treated by her; the lack of treatment results in Makeda collapsing and going into a coma. After the loss of her café, Makeda moves to France to live with Bear's sister, Juliet.
At the 2022 British Soap Awards, Makeda's experiences with racism at St. Phils Hospital was nominated for Best Storyline.

## Chelle Henry

Chelle Henry, portrayed by Kevwe Emefe, first appeared on 6 December 2021 and made her final appearance on 17 February 2022. Emefe announced her casting on Doctors via Instagram on 5 December 2021, the day before her first appearance. She confirmed that Chelle would be a recurring character and that she would be appearing in Doctors "over the next few months". Chelle is introduced as a pregnant patient of Ruhma Carter's (Bharti Patel); she is called in for a checkup having missed numerous appointments. Ruhma questions her absences and Chelle says that she thought she only had to see a midwife if there was a problem. Ruhma arranges standard tests for Chelle, but before she can be tested, she receives a call from a local baby boutique, telling her that an item she wants has come into stock. She leaves the hospital to buy it, and when delivery driver Andy Moore (Dan Hagley) delivers it, she affirms that she will carry it, but he refuses to let her.
While leaving the boutique, Chelle gets Braxton Hicks contractions and is rushed into hospital. Ruhma questions the amount she is buying for the baby and Chelle explains that she wants to provide for her forthcoming baby, even if she goes without. Ruhma explains that due to Chelle growing up in care, she can apply for a bursary for her baby, but Chelle takes offence and leaves, leaving a bag behind. Ruhma delivers the bag to her and sees how empty her house is; excluding the baby's room, which is fully furnished and decorated. Ruhma invites Chelle to a walk in the park for new mothers. Whilst on the walk, Maria Thimbley (Michelle Connolly) suggests several patronising mothering tips to Chelle for her baby, Leon. Initially beginning as a dislike, Chelle eventually "resents" Maria and their disagreements "get out of hand" when they argue.

## Other characters

| Character | Episode date(s) | Actor | Circumstances |
| February ||||
| Mariah Birtelle | 8 February | Nina De Cosimo | A dancer who believes she has a stomach ache. After seeing Ruhma Carter (Bharti Patel), who informs her that she is in labour, she gives birth. |
| Elizabeth Birtles-Boyd | 8 February | Emily De Cosimo | The sister of Mariah (Nina De Cosimo). |
| Barbara Birtles | 8 February | Maggie Daniels | The mother of Mariah (De Cosimo) who informs her children that when she gave birth, she had post-natal depression. |
| Edwin Thomas | 9 February | Richard Hope | A resident of a care home. He believes that Martin Blake (Lindon Alexander) is a Russian spy and runs away to get proof of his beliefs. Alongside Rob Hollins (Chris Walker), he later discovers that care home manager Nancy Davies (Suzann McLean) is the brother of Martin and that they are working together to steal money from the residents. |
| Nancy Davies | 9 February | Suzann McLean | The manager of a care home in Letherbridge who has been working with her brother Martin (Lindon Alexander) to steal money from residents. |
| Martin Blake | 9 February | Lindon Alexander | The brother of Nancy (Suzann McLean) who he works with to steal money from residents of a care home. |
| Terry Walker | 10 February | Jonathan Jaynes | The father of Lily Walker (Verity Rushworth). Al Haskey (Ian Midlane), Lily's fiancé, berates him for being a flat earther. |
| Susan Walker | 10 February | Sherry Baines | The mother of Lily Walker (Rushworth) who is unhappy with her marriage to husband Terry (Jonathan Jaynes). |
| Charles Keegan | 10 February | James Flynn | An NHS fraud prevention officer who investigates how many ghost patients are on the Mill's patient list. |
| Elena Kriezis | 10 February | Maria Forrester | A patient of the Mill who has fraudulently received over £400,000 worth of treatment from the NHS. |
| Marsha Morton | 15 February | Katharine Bennett-Fox | An employee at a leisure centre that feels mistreated by her new boss, Kelvin Fleck (Edward Kelly). After encouragement from Zara Carmichael (Elisabeth Dermot Walsh), she quits to pursue a career as a personal trainer. |
| Kelvin Fleck | 15 February | Edward Kelly | A man who becomes the boss of his uncle's leisure centre and inflicts a variety of changes into the workplace. |
| Giles Price | 16 February | Robin Bowerman | A man who learns from Sid Vere (Ashley Rice) that his wife Alice's (Susan Penhaligon) cancer treatment will not go ahead, since she is too weak for invasive treatment. |
| Alice Price | 16 February | Susan Penhaligon | A woman suffering from dementia, Parkinson's and cancer. |
| Tilly Price | 16 February | Polly Maberly | The daughter of Alice (Penhaligon). |
| Regan Law | 17 February | Melissa Parker | A medical student who funds her research into degenerative diseases by performing life-threatening facial trials on people. |
| Gillian Hall | 17 February | Charlotte Weston | A client of Regan Law's (Melissa Parker). |
| Mo Larkin | 17 February | Kay Purcell | A client of Regan Law's (Parker) who visits Emma Reid (Dido Miles). She has an allergic reaction to Regan's treatment and is taken to A&E. |
| Dixie Calthorpe | 18 February | Marc Pickering | A patient seeing Al Haskey (Ian Midlane). After he opens up to Al about his failing relationship with Katrina Anderson (Jessica Murrain), Dixie gets on the roof of the Mill to get Katrina's attention. |
| Katrina Anderson | 18 February | Jessica Murrain | A maintenance worker at the Mill. Her boyfriend, Dixie Calthorpe (Marc Pickering), gets on the roof at the Mill to get her attention after she expresses plans to move abroad. |
| DS Suresh Nupur | 22 February | Liam Tamne | A detective sergeant who investigates the death of Kelly, a drug dealer. |
| Ewan Daley | 22 February | Gabriel Scott | A student support officer at Letherbridge University. |
| Nathan McBride | 22 February | Jaz Hutchins | A university student who attempts to aid DS Suresh Nupur (Liam Tamne) in his investigations. |
| Amy Rouse | 22 February | Felix Forde | A university student who accidentally pushed drug dealer Kelly down a flight of stairs. |
| Jonno Parker | 24 February–26 May | Tommy Sim'aan | The brother of Billy (Daniel Cornish). He threatens Luca McIntyre (Ross McLaren) since he blames him for Billy's death. |
| Noah Levi | 24 February | Alun Raglan | The former boss of Luca McIntyre (McLaren). Luca quits working for him after Noah calls him a homophobic slur. |
| Mavis Gregg | 24 February | Melanie Kilburn | A patient of Luca McIntyre (McLaren). |
| Billy Parker | 24 February | Daniel Cornish | The boyfriend of Luca McIntyre (McLaren) who dies in a car accident. |
| Roberta | 24 February | Bharti Patel | A colleague Luca McIntyre's (McLaren). |
| Max | 24 February | Matthew Chambers | A consultant for medication at Noah Levi's (Alun Raglan) surgery. |
| Jackie | 24 February | Sarah Moyle | A friend of Luca McIntyre's (McLaren). |
| Phil Addison | 25 February | Paul McQuaid | A porter at St. Phils hospital who is expecting a baby with Jane Goodwin (Kate Somerton). Jane later informs him that she has miscarried the baby and when he is only concerned about trying for another baby, she ends their relationship. |
| Jane Addison | 25 February | Kate Somerton | A patient of Ruhma Carter's (Bharti Patel) who miscarries her baby. |
| Carole Simmons | 25 February | Anjela Lauren Smith | A social worker who informs Karen Hollins (Jan Pearson) that she cannot continue caring for Tom Robson (Max True) due to his violence. |
| March ||||
| Maisie Wilson | 1–23 March | Silvia Presente | A pair of environmental activists at Letherbridge University. Due to disagreeing with the university going into partnership with a company called Secuto, they glue their hands to a classroom door. Daniel Granger (Matthew Chambers) is called out to dissolve the glue. They explain that Secuto use fossil fuels such as oil, which has a negative impact on the environment. Daniel advises them to protest in a different way, and the pair decide to do a hunger strike. Daniel informs them that they will die if they continue the strike. Maisie and Anita confront pro-vice-chancellor Matthew Portman (Jason Thorp), who tells them that the strike will not impact the partnership deal. Anita's classmate Eddie Bryant (Edward Nkom) disagrees with their protest, and after the pair argue, Anita collapses and is taken into hospital. She reveals that she has Chron's disease, which leads to her quitting the hunger strike due to her health. Maisie continues the strike for another week, but due to feeling weak, she reluctantly quits. |
| Anita Chandola | 1–23 March | Hannah Khalique-Brown | A pair of environmental activists at Letherbridge University. Due to disagreeing with the university going into partnership with a company called Secuto, they glue their hands to a classroom door. Daniel Granger (Matthew Chambers) is called out to dissolve the glue. They explain that Secuto use fossil fuels such as oil, which has a negative impact on the environment. Daniel advises them to protest in a different way, and the pair decide to do a hunger strike. Daniel informs them that they will die if they continue the strike. Maisie and Anita confront pro-vice-chancellor Matthew Portman (Jason Thorp), who tells them that the strike will not impact the partnership deal. Anita's classmate Eddie Bryant (Edward Nkom) disagrees with their protest, and after the pair argue, Anita collapses and is taken into hospital. She reveals that she has Chron's disease, which leads to her quitting the hunger strike due to her health. Maisie continues the strike for another week, but due to feeling weak, she reluctantly quits. |
| Janine Aitken | 1 March | Anna Martine-Freeman | A con artist who tries to scam Valerie Pitman (Sarah Moyle) out of £850 by claiming to be a hand model agent. |
| Bob Wainwright | 2 March | Rupert Holliday-Evans | A man with a tumour in his frontal lobe, making him believe in alien activity. |
| Charlie Wainwright | 2 March | Luke Lowry | The son of Bob (Rupert Holliday-Evans). |
| Harvey Dowling | 2 March | Tom Aldwinckle | The site manager of a team building resort that the colleagues of the Mill visit. |
| Jenson Kendrick | 3 March | Toyin Omari-Kinch | An ex-prisoner who attends counselling sessions with Jimmi Clay (Adrian Lewis Morgan). |
| Sophie Herron | 3 March | Dominique Jackson | The girlfriend of Jason Kendrick (Toyin Omari-Kinch) who struggles to process that he is an ex-prisoner due to having been in an abusive relationship prior to meeting him. |
| Connor Finch | 3 March | Jimmy Fairhurst | A colleague of Jason Kendrick (Omari-Kinch). |
| Linda Webb | 4 March | Lesley Molony | The mother of Charley (Grace Molony), who is dying from leukaemia. She finds her estranged daughter Maya Clough (Matilda Tucker) in the hope that she can donate a stem cell. |
| Charley Webb | 4 March | Grace Molony | A woman dying from leukaemia. She meets her estranged sister Maya Clough (Tucker) when her mother hopes that Maya can donate a stem cell to her. |
| Maya Clough | 4 March | Matilda Tucker | The pregnant estranged sister of Charley Webb (Molony). |
| Mandi Tyler | 4 March | Letitia Hector | A woman that has a friends with benefits relationship with Bear Sylvester (Dex Lee), until Sid Vere's (Ashley Rice) kind nature shows her that she wants more from a partner. |
| Harriet Bentley | 8 March | Blue Merrick | A friend of Zara Carmichael's (Walsh) who visits a psychic Grace Perlman (Ellie Darvill), to cope with the death of her son. |
| Grace Perlman | 8 March | Ellie Darvill | A psychic who Zara Carmichael (Walsh) exposes for taking advantage of grieving people. |
| Matthew Portman | 9–23 March | Jason Thorp | The pro-vice-chancellor of Letherbridge University. He meets with Daniel Granger (Matthew Chambers) to discuss the hunger strike led by students Anita Chandola (Hannah Khalique-Brown) and Maisie Wilson (Silvia Presente), as he wants them to stop the strike for financial reasons. After facing pressure from the students and Daniel threatening to pull surgery services from the university, he begins attending counselling sessions with Jimmi Clay (Adrian Lewis Morgan). |
| Max Dutch | 9 March | John Askew | A man who aspires to be a midwife. He helps to deliver his child with wife Poppy (Elizabeth Twells). |
| Poppy Dutch | 9 March | Elizabeth Twells | A woman who gives birth to her child with husband Max (John Askew). |
| Tel Dutch | 9 March | William Ilkley | The father of Max (Askew). |
| Debbie Snell | 10 March | Emma Manton | A woman with schizophrenia who becomes convinced that her daughter Rosie (Naomi Morris) was swapped at birth. |
| Eddie Bryant | 10 March | Edward Nkom | A classmate of Anita Chandola's (Khalique-Brown) who disagrees with her protest against Secuto. |
| Rosie Snell | 10 March | Naomi Morris | The daughter of Debbie (Emma Manton), who is unaware of her mother's mental illness. |
| Sue Snell | 10 March | Cally Lawrence | The mother of Debbie (Manton) who reveals to Rosie (Morris) that Debbie has schizophrenia. |
| Serena Chandola | 11–16 March | Buckso Dhillon-Woolley | The mother of Anita (Khalique-Brown). When Anita collapses from a hunger strike, Serena blames her friend, Maisie Wilson (Presente). |
| Colin Turner | 11 March | David Schaal | The sugar daddy of Chloe Jardine (Rebecca Finch), who tells her that he has developed romantic feelings for her. |
| Chloe Jardine | 11 March | Rebecca Finch | The sugar baby of Colin Turner (David Schaal). |
| Jake Haggard | 11 March | Matt Barkley | The boyfriend of Chloe Jardine (Finch). |
| Sammy Russell | 15 March | Ilan Galkoff | A 14-year-old who vandalises Bear Sylvester's (Lee) car. Bear later discovers that Sharon Coombs (Gemma Layton) has groomed him into selling drugs. |
| Wayne Jackson | 15 March | Calum Hayes | The disabled brother of Sammy (Ilan Galkoff). He takes Sammy's LSD and jumps out of a window. |
| Sharon Coombs | 15 March | Gemma Layton | A drug dealer who grooms Sammy Russell (Galkoff) into selling drugs by posing as a carer. |
| Samuel Asante | 16 March | Trevor Laird | The overbearing father of Akua (Yasmin Mwanza). |
| Akua Asante | 16 March | Yasmin Mwanza | A woman who struggles when going into labour. |
| Chris Robinson | 16 March | Tej Obano | The partner of Akua Asante (Mwanza). |
| Francis Kelley | 17 March | Eoin Geoghegan | The father of sixth form medical student Teresa (Alexandra O'Neill). He injures his wrist, but is agitated about registering at the Mill as he cannot read. |
| Teresa Kelley | 17 March | Alexandra O'Neill | A sixth form medical student who shadows Sid Vere (Rice) at the Mill for work experience. |
| Evie Steele | 18 March | Sophie Ford | A teenager who gives up studying nursing at university in order to care for Graham (Jonty Stephens), her father with dementia. |
| Graham Steele | 18 March | Jonty Stephens | A man with dementia. He is cared for by daughter Evie (Sophie Ford). |
| Chloe Shapley | 18 March | April Pearson | Evie Steele's (Ford) sister. Evie discovers that Chloe once had an opportunity to put their father in a care home, but declined due to the cost of his treatment. |
| Dr Sadiqa Anwar | 22 March | Marina Manoharan | A woman who attends Zara Carmichael (Walsh) and Emma Reid's (Miles) menopause support group despite being post-menopausal. |
| Nicky Connelly | 22 March | Wendi Peters | A woman who attends Zara Carmichael (Walsh) and Emma Reid's (Miles) menopause support group due to having heightened anger. |
| Esther Waterman | 22 March | Helene Maksoud | A woman who attends Zara Carmichael (Walsh) and Emma Reid's (Miles) menopause support group due to feeling ugly. |
| Ron Sewell | 23 March | Steven Hillman | A man who reunites with his brother Jeff (Stephen Bent) after living in Spain for 15 years. |
| Jeff Sewell | 23 March | Stephen Bent | A man who is targeted by a local gang on his estate. |
| Tyson Ross | 23 March | Dillon Scott-Lewis | A gang leader who targets Jeff Sewell (Bent). |
| Lewis Ainsley | 24 March–19 May | John Leader | A friend of Sid Vere (Rice) who asks him to get involved in his fundraising activities for a meningitis charity since they were both affected by the disease in their childhood. After hosting the final charity event, Lewis feels tired and returns home. He then dies from a heart arrhythmia. |
| Taya Barnett | 24 March | Maxine Finch | A woman who saves money for over ten years to visit her estranged family in Zimbabwe. She learns that her husband John (Andrew Lewis), a gambling addict, has used all of her saved money. |
| John Barnett | 24 March | Andrew Lewis | A gambling addict who uses his wife's savings to fund daughter Selina's (Mica Ricketts) business, as well as gambling. |
| Selina Barnett | 24 March | Mica Ricketts | The daughter of Taya (Finch) and John Barnett (Lewis). She pleads with John to lend her money to fund her business proposal, which fails. |
| Tony Loreto | 25 March | Enzo Squillino Jr. | The father of Adam (Matthew Marcelis) who refuses to believe that he has schizophrenia like his mother. |
| Adam Loreto | 25 March | Matthew Marcelis | A university graduate who suffers from the symptoms of schizophrenia. |
| Mandy Gilbert | 25 March | Helen Sheals | The schizophrenic mother of Adam Loreto (Marcelis). |
| Andy Simm | 29 March | Ross Gilby | An ex-convict who spends time with Patricia Stanton (Clare Clifford) since she is elderly and lonely. When she attempts to kill herself with a knife, Rob Hollins (Walker) assumes Andy has tried to kill her for money. |
| Marcus Waites | 29 March | Ryan Cloud | The great-nephew of Patricia Stanton (Clifford). |
| Patricia Stanton | 29 March | Clare Clifford | An elderly woman who tries to kill herself due to loneliness. |
| Marc Wilcox | 30 March | Marc Butters | A young police officer who accidentally stabs and kills an abuser. |
| Dave Conroy | 30 March | Tim Treloar | A retiring police officer who tries to cover for Marc Wilcox's (Marc Butters) accident. |
| Shaun Wilcox | 30 March | Victor Gardener | Marc Wilcox's (Butters) father who tries to bribe his bosses in order to protect Marc's career. |
| Kate Campbell | 31 March | Elizabeth Cadwallader | A patient of Ruhma Carter's (Patel) who has two miscarriages. After going on the pill, she accidentally gets pregnant and gives birth. |
| Tom Campbell | 31 March | Lloyd Thomas | The husband of Kate (Elizabeth Cadwallader) who struggles to cope with the couple's two miscarriages. |
| April ||||
| Bryan Easton | 1 April | Martyn Ellis | A radio broadcaster who struggles with high blood pressure. He attends a group consultation with Al Haskey (Midlane), who advises him to make a follow-up appointment. |
| Carrie Kwouk | 1 April | Rachel Lin | A graphic novelist who attends a group consultation with Al Haskey (Midlane) after suffering from high blood pressure caused by her job. |
| Stefan Hywel | 1 April | Steven Meo | A man who attends a group consultation with Al Haskey (Midlane) due to suffering from high blood pressure caused by his abusive girlfriend. Fellow attendee Carrie Kwouk (Rachel Lin) encourages him to leave her. |
| Alison Murray | 19 April | Rachel Denning | A woman with dwarfism who discovers that rugby player Jake Ashcroft (Chris Eastwood) had sex with her to be initiated into his rugby team. She exposes him to his pregnant girlfriend by pretending she has given him chlamydia. |
| Jake Ashcroft | 19 April | Chris Eastwood | A man who sex with Alison Murray (Rachel Denning) to be initiated into his rugby team. He confesses to pregnant girlfriend Lauren Jones (Natalie O'Neill) since he believes Alison has given him chlamydia. |
| Lauren Jones | 19 April | Natalie O'Neill | A pregnant woman who learns that her boyfriend has cheated on her and may have given her chlamydia. She later leaves him. |
| Dr Elaine Harris | 19 April | Andrea Crewe | An oncologist who informs Valerie Pitman (Moyle) that she may have cancer again. She books her in for a scan. |
| Connie Hinkley | 20 April | Nicky Goldie | A former children's home matron who has her dog killed by Kevin Newly (Josef Hyland) as revenge for her ignoring him being sexually abused in the home as a child. |
| Kevin Newly | 20 April | Josef Hyland | A man who was sexually abused as a child whilst staying in a children's home. He poisons Connie Hinkley's (Nicky Goldie) dog as revenge, since she was the matron and ignored what was happening. |
| James Collins | 21 April | Simon Poland | A priest who, after the death of his partner, decides he does not want to fight his illness. Luca McIntyre (McLaren) encourages him to take treatment. |
| Saif Hamed | 21 April | Joeraver Sangha | A man with testicular cancer who calls off his wedding as he is scared about informing his fiancée about his diagnosis. |
| Judith Holland | 21 April | Bella Hamblin | A woman who ends her marriage with husband Simon (Sean Connolly) after discovering his various affairs. |
| Simon Holland | 21 April | Sean Connolly | A theatre actor who cheats on wife Judith (Bella Hamblin) with various women at his shows. |
| Thomas Kaplan | 22 April | Graham Bryan | A man who has cheated on wife Sue (Cindy Humphrey) with Brittany Paddock (Sally Mason); he later decides he wants Sue back. He is dumped by both women. |
| Sue Kaplan | 22 April | Cindy Humphrey | The neighbour of Karen Hollins (Pearson) whose husband has cheated on her. |
| Brittany Paddock | 22 April | Sally Mason | The new wife of Thomas Kaplan (Graham Bryan) who dumps him when she discovers that he wants his old wife back. |
| Zach Wilson | 26–27 April | Luke Grant | A man that Luca McIntyre (McLaren) meets through a dating app and goes on a date with. When he gets too drunk on the date, he accidentally headbutts Luca when trying to give him a hug. |
| Josh Brooks | 26 April | Ryan Dean | A 21-year-old who ends up in prison after dreaming of becoming a footballer. |
| Owen Charlton | 26 April | Robert Boulter | A documentary maker who includes Josh Brooks (Ryan Dean) and Bradley Preston (Kwame Kandekore) in his documentary. |
| Melanie Truman | 26 April | Caroline Parker | A prison guard who expresses a dislike in both the prisoners and her job. |
| Bradley Preston | 26 April | Kwame Kandekore | A friend of Josh Brooks (Dean) who becomes a footballer. |
| Maureen Brennan | 28 April | Elizabeth Elvin | A woman that Valerie Pitman (Moyle) visits after discovering a photo of a young child in front of Maureen's house. |
| Martin Worth | 28 April | Tyler Blythin | A man with a stammer that witnesses his friend, Drew Worth (Jamie O'Neill), get attacked for defending him. |
| Drew Worth | 28 April | Jamie O'Neill | A man who gets attacked after defending his friend, Martin Worth (Tyler Blythin), who has a stammer. |
| Rachel Coleman | 29 April | Melanie Gutteridge | The mother of Jemma (Erin Grace), who learns that she has an atrial myxoma. Rachel puts her into contact with her estranged father. |
| Jemma Coleman | 29 April | Erin Grace | The daughter of Rachel who, after 26 years, is put into contact with her father, Dave Mercer (Rufus Wright). |
| Dave Mercer | 29 April | Rufus Wright | The estranged father of Jemma Coleman (Erin Grace). He assures her that he has wanted to be in contact with her for years. |
| May ||||
| Evie Bailey | 4 May | Sarah Thom | The daughter of Sally (Bebe Sanders) who takes a job in Malaysia. When she learns that her mother is dying from cancer, she visits her to say goodbye alongside her brother. |
| Oliver Bailey | 4 May | Michael Jinks | The son of Sally (Sanders) who takes care of her until she dies of cancer. |
| Sally Bailey | 4 May | Bebe Sanders | A friend of Jimmi Clay's (Morgan) who is treated by him for over ten years. She is diagnosed with colon cancer, and despite being cured numerous times, it eventually spreads to her spine, lungs and brain. She eventually dies in hospital. |
| Darren Homewood | 5 May | Corey Trevor | An ex-convict who cares for his grandmother, Hannah (Angela Curran). Hannah gives him the deed to her house on her deathbed. |
| Hannah Homewood | 5 May | Angela Curran | The grandmother of Darren (Corey Trevor) who suffers from dementia. On her deathbed, she gives the deeds to her house to Darren with police officers Rob Hollins (Walker) and Harriet Shelton (Carley Stenson) acting as their witnesses. |
| Donna Homewood | 5 May | Demelza O'Sullivan | The daughter of Hannah (Curran), who taught her shoplifting techniques. |
| Nathan Sallery | 6–27 May | James Barriscale | A man who appeared in a photograph as a child, which is found by Valerie Pitman (Moyle). When she arrives at his house to tell him about her findings, he dismisses her. The next day, he visits the Mill to apologise to Valerie. The pair agree to go on a date and begin dating, but Nathan is dismayed when Valerie tells him that she is looking for adventure and that he is too boring for her. |
| Alanna Huxley | 6 May | Jennie Dale | Three chefs who compete against Ruhma Carter (Patel), Al Haskey (Midlane) and Sid Vere (Rice) in a sports day organised by Lewis Ainsley (John Leader) to raise money for a meningitis charity. |
| Jenny Chess | 6 May | Adaya Henry | Three chefs who compete against Ruhma Carter (Patel), Al Haskey (Midlane) and Sid Vere (Rice) in a sports day organised by Lewis Ainsley (John Leader) to raise money for a meningitis charity. |
| Cynthia Cavalli | 6 May | Elizabeth Hill | Three chefs who compete against Ruhma Carter (Patel), Al Haskey (Midlane) and Sid Vere (Rice) in a sports day organised by Lewis Ainsley (John Leader) to raise money for a meningitis charity. |
| Patrick Barclay | 10 May | Andrew Langtree | A man with agoraphobia caused by both the death of his brother and the COVID-19 pandemic. |
| Lynda Barclay | 10 May | Sarah Middleton | The sister of Patrick (Andrew Langtree) who pretends to have stomach cancer in order to help him combat his agoraphobia. |
| Ali Gill | 10 May | Neil Paul | A childhood friend of Lynda Barclay (Sarah Middleton) who is disgusted with her when she lies about having stomach cancer. |
| Barbara Hughes | 11 May | Gemma Page | The birth mother of Nathan Sallery (James Barriscale) who suffers from memory loss due to having undergone electroshock therapy in her youth. |
| Gerard Hughes | 11 May | Michael Kirk | The husband of Barbara (Gemma Page) who has cared for her throughout their marriage. |
| Joel Cooke | 11 May | Aaron Sidwell | The expecting father of Charmaine's (Tricia Adele-Turner) baby who runs an online video channel. |
| Charmaine Cooke | 11 May | Tricia Adele-Turner | The pregnant wife of Joel (Aaron Sidwell) who learns that their child will be born with a disability. |
| Vicki | 12 May | Anna Acton | A woman who goes on a date with Al Haskey (Ian Midlane). He later realises that she pretended to be his real date, and questions her, where Vicki reveals that she routinely pretends to be other people to escape a mundane life. |
| Jess Morgan | 12 May | Amey Woodhall | The friend of Vicki (Anna Acton) who gets too drunk in a bar owned by TK Nelson (Adam Deacon). |
| TK Nelson | 12 May | Adam Deacon | The owner of a bar who challenges Al Haskey (Midlane) to a bet which Al wins. |
| Ashley Jackson | 13 May | Mark Sheals | A prisoner at HMP Letherbridge who is set to be released the following week. |
| Craig Emerson | 13 May | Khalid Daley | A prisoner at HMP Letherbank who receives help from Daniel Granger (Matthew Chambers) concerning being bullied in prison. |
| Danny Taylor | 13 May | Joshua Osei | A prisoner at HMP Letherbank who tries to make Craig Emerson (Khalid Daley) smuggle drugs into the prison. |
| Michael Norris | 17 May | Thapelo Ray | A teenager who dislikes his mother's new partner since he is enabling her drug addiction. |
| Sasha Norris | 17 May | Adrienne Grant | A woman who is groomed into a drug addiction by drug dealer Byron Hall (James Palmer). |
| Byron Hall | 17 May | James Palmer | A drug dealer who grooms Sasha Norris (Adrienne Grant) into forming a drug addiction. |
| Matthew Wargate | 18 May | Liam Ainsworth | A man who is undergoing "superhero therapy" with therapist Philip Laws (Adam Ewan) since he accidentally killed the parents of Stephen Powers (Sam C Wilson) whilst drunk driving. |
| Philip Laws | 18 May | Adam Ewan | A therapist who offers "superhero therapy" to Matthew Wargate (Liam Ainsworth). Al Haskey (Midlane) criticises his professionalism since he takes two-day courses to keep up with therapy trends. |
| Stan Barrett | 18 May | Paul Jerricho | An elderly man who is visited biweekly by care volunteer Matthew Wargate (Ainsworth). |
| Stephen Powers | 18 May | Sam C Wilson | A man who grew up in foster care due to Matthew Wargate (Liam Ainsworth) killing his parents whilst drunk driving. |
| Kelly Beck | 19 May | Kezia Burrows | A patient of Sid Vere's (Rice) who has recently split from her abusive husband. Her friend Ashley Kershaw (Poppy Roe) attempts to set her up on a date with both Sid and Lewis Ainsley (John Leader). |
| Ashley Kershaw | 19 May | Poppy Roe | A friend of Kelly Beck's (Kezia Burrows) who attempts to set her up on dates following Kelly's split from her husband. |
| Grant Hodgson | 20 May | Ruben Crow | A married couple who have several arguments and decide to split up whilst on a survival course with Alec Dearmer (Fin Gardner). |
| Denise Hodgson | 20 May | Zannah Hodson | A married couple who have several arguments and decide to split up whilst on a survival course with Alec Dearmer (Fin Gardner). |
| Alec Deamer | 20 May | Fin Gardner | A survival course instructor who hosts a course with Valerie Pitman (Sarah Moyle), Nathan Sallery (James Barriscale) and the Hodgsons. |
| Ed Benson | 25 May | Delroy Brown | A friend of Al Haskey's (Midlane) who calls Al to fix the internet connection at his workplace. Al encourages him to ask Liv Keane (Elinor Lawless) on a date. |
| Liv Keane | 25 May | Elinor Lawless | A gardener working at Ed Benson's (Delroy Brown) workplace; the two form a romantic connection and agree to go on a date. |
| Owen Keane | 25 May | Damien James | The son of Liv (Lawless) who has a talent for computing. |
| Kirk Eames | 25 May | Elliot Rodriguez | A friend of Jonno Parker's (Tommy Sim'aan). He does not allow Jonno to stay at his house while on drugs since he has a wife and kids. |
| Gary Watkins | 26 May | Graeme Brookes | A man who tries to help Zara Carmichael (Walsh) out of her car when she gets locked inside. |
| Layla Roberts | 27 May | Jasmine Armfield | A vegan activist who discovers her boyfriend, Tom Ashwood (Loris Scarpa), is in debt and has a drug addicted mother. |
| Tom Ashwood | 27 May | Loris Scarpa | The boyfriend of Layla Roberts (Jasmine Armfield) who reveals that his mother is addicted to drugs and that he is in a lot of debt. Jimmi Clay (Morgan) gives him a scratchcard that he won £5000 on in order for Tom to pay his debts off. |
| Cynthia Ainsley | 27 May | Karlina Grace-Paseda | The mother of Lewis (Leader) who invites his friend, Sid Vere (Rice), to Lewis' wake following his death. |
| June ||||
| Amy Papoutsis | 1 June | Ruby-May Martinwood | A teenage patient of Ruhma Carter's (Patel) who is pregnant. Her family and friends do not know of the baby until classmate Mason Higgs (Billy Angel) accidentally tells her father. |
| Kris Papoutsis | 1 June | Christopher Sciueref | The father of Amy (Ruby-May Martinwood). |
| Mason Higgs | 1 June | Billy Angel | A classmate of Amy Papoutsis' (Ruby-May Martinwood) who accomanies her to her hospital appointment. |
| Ryan Holland | 2 June | James Teague | A teenager suffering from grief after the death of his mother. |
| Ade Holland | 2 June | Ian Hallard | The father of Ryan (James Teague) and a Letherbridge councillor that works with Al Haskey (Midlane). |
| Hayley Wilkins | 2 June | Dayna Bateman | A teenager who lives in a youth hostel due to her tumultuous relationship with her mother. |
| Jackie Wilkins | 2 June | Susie Riddell | The mother of Hayley (Dayna Bateman) who meets with Al Haskey (Midlane) and Bear Sylvester (Lee) when she goes missing. |
| Becky Buckley | 3 June | Samantha Robinson | The colleague and girlfriend of Barry Biglow (David Perks) who has an overly high sex drive. The pair see Emma Reid (Miles) as Barry is unable to keep up with Becky and Emma informs her that her increased sex drive is due to her recent antidepressants prescription. |
| Bella Bentley | 4 June | Alice Henley | A contestant in Sid Vere's (Rice) treasure hunt. She is accompanied by her friend Will Gould (Darren Hart). She later reveals to him that Stuart Mangold (Simon Tcherniak) sexually assaulted her. |
| Will Gould | 4 June | Darren Hart | A friend of Bella Bentley's (Alice Henley) who accompanies her to a treasure hunt. |
| Stuart Mangold | 4 June | Simon Tcherniak | An NHS boardman who meets with Bear Sylvester (Lee) to discuss the wellbeing of an overweight patient who needs an operation. He is impressed by Bear's debating skills and says he would fit in well with the panel, but when Bear learns that Stuart has sexually assaulted Bella Bentley (Henley), he threatens to expose Stuart. |
| Nick Owen | 7 June | Himself | An interviewer who interviews Sid Vere (Rice) about his efforts for a meningitis charity. |
| Alan Carling | 7 June | Nathan Sussex | A widower who is suffering from stress and potential prostate cancer. |
| Liam Bright | 7 June | Jon-Paul Bell | The adoptive son of Alan Carling (Nathan Sussex) who worries about his health after losing his other adoptive father. |
| Jen Mason | 7 June | Catrin Powell | The unreliable sister of Alan Carling (Sussex) who he kicks out. |
| Mary McRae | 8 June | Leslie Ash | A woman who discovers that a man she loved had several affairs following his death. |
| Joan Brown | 8 June | Buffy Davis | The wife of a man who has recently died. She informs Mary McRae (Leslie Ash), one of his affair partners, that he had several affairs through her marriage to him. |
| Marie Scally | 9 June | Rachel Bruce | A university student who acquires medication from Al Haskey (Midlane) so that she can drug Jacob Willis (James McDowall) as revenge for hosting a competition to have sex with her. She burns his clothes and takes photos of him in poorly done makeup to humiliate him. |
| Jacob Willis | 9 June | James McDowall | A university student who competes with other students to see who can have sex with the "poorest girl on campus", Marie Scally (Rachel Bruce). |
| Mikey Kane | 9 June | Zheng Xi Yong | The friend of Jacob Willis (McDowall) who believes his treatment of women is poor. |
| Jenny Carver | 9 June, 20 October | Elexi Walker | The boss of Sid Vere (Rice) who sends him home from a rapid response shift for being drunk. |
| Joanna Jacobs | 10 June | Jo Richards | A gardener who has violent tendencies towards her daughter Ruby (Ruby Richards). |
| Ruby Jacobs | 10 June | Ruby Richards | The daughter of Joanna (Jo Richards) who gets excluded from school for being repeatedly late. |
| Davey Willows | 10 June | William Hayes | The boss of Joanna Jacobs (Richards) who allows her time off after an injury, giving her shifts to her troublesome daughter Ruby (Richards). |
| Mr Whiteleg | 10 June | Steve Giles | An accountant who Bear Sylvester (Lee) attends an online audit meeting with. |
| Ben Harrison | 11 June | Ian Weichardt | A colon cancer survivor who is being abused by his girlfriend Moira Cole (Crystal Condie). Luca McIntyre (McLaren) helps him to realise that Moria's treatment of him is abuse and encourages Ben to leave her when he feels ready. |
| Moira Cole | 11 June | Crystal Condie | The abusive girlfriend of Ben Harrison (Ian Weichardt). |
| Scott Cooper | 15 June | Matt Tait | The husband of Zoe (Lizzie Stables) who calls Ruhma Carter (Patel) when he fears she has relapsed into her psychosis. |
| Zoe Cooper | 15 June | Lizzie Stables | A new mother who mistakes a vision problem for a psychosis relapse. |
| Sophia Wheatley | 17 June | Maeve Courtier-Lilley | The 16-year-old sister of Duncan (Jack Carroll) who suffers from endometriosis. She uses his dating app account to pay Jason Duquette (Jon Glasgow) to have sex with Duncan since she pities him for being a virgin. |
| Duncan Wheatley | 17 June | Jack Carroll | A virgin who is advised by McIntyre (McLaren) to meet people in person as opposed to using dating apps. |
| Jason Duquette | 17 June | Jon Glasgow | A sex worker who is paid by Sophia Wheatley (Maeve Courtier-Lilley) to have sex with her brother. |
| Rich Marshall | 21 June | Simon Wilson | A hospital surgeon who opens up to Daniel Granger (Chambers) about his suicidal thoughts following the rise of deaths of patients during the COVID-19 pandemic. |
| Carla Marshall | 21 June | Felicity Green | The daughter of Rich (Simon Wilson) who contacts his ex-partner Judy Sutton (Bridgitta Roy) when she learns of his suicidal thoughts. |
| Judy Sutton | 21 June | Bridgitta Roy | The ex-partner of Rich Marshall (Wilson) who lends her support when she learns of his suicidal thoughts. |
| Ginny Redman | 22 June | Rebecca Bainbridge | A violinist that Ruhma Carter (Patel) recognises from when she performed for her and her dead husband Heston (Owen Brenman). |
| Lloyd | 22 June | Lloyd Gorman | A violinist who performs with Ginny Redman (Rebecca Bainbridge). |
| Paul Brooks | 23 June | Ben Moor | The brother of Hattie (Harriet Thorpe) who gives Valerie Pitman (Moyle) a rock painted like a ladybird. |
| Hattie Brooks | 23 June | Harriet Thorpe | The owner of a field where Valerie Pitman (Moyle) stays. She pushes Valerie to leave. |
| Maise Oliver | 23 June | Helen Lederer | A birdwatcher at a lake where Valerie Pitman (Moyle) visits. |
| Geoffrey the Cat | 23 June | Ian Midlane | Valerie Pitman's (Moyle) dead cat who visits her in a dream to advise her on her future. |
| Aaron Jeffries | 24 June–9 September | Zak Douglas | A criminal who taunts Rob Hollins (Walker) after Rob cannot catch him for trespassing in a community building. Harriet Shelton (Stenson) finds him lifeless at the bottom of a staircase, with Rob standing over him. When he awakens from his unconscious state, he is questioned by Inspector Zoya Okoro (Donna Berlin) and tells her that Rob is responsible for his fall. |
| Lenny Calhoun | 24 June | Lewis Conway | The criminal friend of Aaron Jeffries (Zak Douglas) who escapes before he is caught by the police. |
| Grahame Ford | 24 June | Nicholas Chambers | A man whose bike is nearly stolen by Aaron Jeffries (Douglas) and Lenny Calhoun (Nicholas Chambers). |
| September ||||
| Inspector Zoya Okoro | 6–27 September | Donna Berlin | An inspector who investigates a case where Aaron Jeffries (Douglas) is found unconscious at the bottom of a flight of stairs. |
| Andrew Hamilton | 6 September | Ashley Campbell | The fashion designer son of Isabel (Judy Clifton) who persuades Emma Reid (Miles) to buy a dress from him. |
| Isabel Hamilton | 6 September | Judy Clifton | The mother of Andrew (Ashley Campbell) who refuses to part with her favourite chair. |
| Adam Hartman | 7 September | Tim Preston | A medical student who confronts famous anti-vaxxer Sarah Franks (Lola-Rose Maxwell) regarding her attitudes towards vaccines. |
| Sarah Franks | 7 September | Lola-Rose Maxwell | An actress who is popular online, where she posts videos about her vaccine hesitancy. |
| Gerry Glover | 8 September | Dominic Geraghty | A handyman who saves the life of Lulu Ronson (Emily Drewett) after finding her collapsed inside of her university accommodation. |
| Ellen Croft | 8 September | Michele Moran | The housing officer of Letherbridge University who neglects students including asthmatic Lulu Ronson (Drewett). |
| Lulu Ronson | 8 September | Emily Drewett | An asthmatic patient of Al Haskey's (Midlane) who sees him about struggling to breathe due to the mould and damp walls in her university accommodation being a trigger for her asthma. |
| Mira Hyde | 9 September | Laura Doddington | The mother of a 10-week-old baby who struggles to cope with motherhood due to her own mother dying. Valerie Pitman (Moyle) calls for social services to support Mira. |
| Nancy Bradshaw | 13 September | April Nerissa Hudson | A rapid responder who joins Sid Vere (Rice) on a shift. |
| Iris Cotterill | 13 September | Cody Ryan | A teenager whose mother dies in front of her after having waited too long for an ambulance to arrive. |
| Gabriel Chase | 13 September | Jay Perry | An emergency medical dispatcher who is frustrated with how long it takes for an ambulance to reach Iris Cotterill (Cody Ryan) and her dying mother. |
| Marvin Bulis | 14–23 September | Philip Martin Brown | A homeless man who claims to have witnessed Harriet Shelton's (Stenson) involvement with what happened to Aaron Jeffries (Douglas). |
| James McAllister-Lipinski | 14 September | Craig Painting | The husband of Piotr (Ellis Kirkhoven); the pair run a doctor's surgery together. |
| Piotr McAllister-Lipinski | 14 September | Ellis Kirkhoven | The husband of James (Craig Painting); the pair run a doctor's surgery together. |
| The Inspector | 14 September | Edward Aczel | An inspector visiting James (Painting) and Piotr McAllister-Lipinski's (Kirkhoven) surgery to perform an inspection. |
| Nick Meadows | 15 September | Ashley Margolis | A man who begins to suffer from cotard's syndrome following the death of his 11-year-old son, in which he was unable to save him. |
| Tina Meadows | 15 September | Kelly Clare | The wife of Nick (Ashley Margolis) who learns that she is pregnant. |
| AJ Hawley | 16–21 September | Catherine Hannay | A researcher on the fictional antique-hunting series Booty or Bust. She interviews Ruhma Carter (Patel) and Al Haskey (Midlane). |
| Doreen 'Dor' Goddard | 16 September | Tina Harris | The mother of Luke (Daniel Stiller) who informs him that due to her ancestry, he may have sickle cell disease. |
| Andy Goddard | 16 September | Chas Early | The husband of Doreen (Tina Harris) who realises that his racist comments are inappropriate and have offended Doreen. |
| Luke Goddard | 16 September | Daniel Stiller | A runner and the son of Doreen (Harris) who learns he may have sickle cell disease. |
| PC Royce | 20–21 September | Ryan Mal | A police officer who is informed by Emma Reid (Miles) and Valerie Pitman (Moyle) that Marvin Bulis (Philip Martin Brown) may have seen Harriet Shelton (Stenson) push Aaron Jefferies (Douglas) down a flight of stairs. |
| Cecilia Kotak | 20–21 September | Me'sha Bryan | The presenter of Booty or Bust, an antique hunting series. |
| Clive Cookson | 20–21 September | Kim Wall | An expert on Booty or Bust. Believing he is better than the job, he threatens to leave the series until he is informed that he cannot book another role. However, he is fired by the programme's director. |
| Barbara Cookson | 20–21 September | Alison Egan | An expert on Booty or Bust. She teams up with contestant Marji Webster (Doreene Blackstock). She later reveals to her husband Clive (Kim Wall) that she has been cheating on him with Marji for over a year. She is fired by the programme's director. |
| Bill Anderson | 20–21 September | David Hunter | The director of Booty or Bust. |
| Marji Webster | 20–21 September | Doreene Blackstock | A contestant on Booty or Bust who reveals herself as Barbara Cookson's (Alison Egan) partner. |
| Peter Bone | 21 September | Tim Hibberd | An auctioneer on Booty or Bust who gets promoted to an expert on the series after Clive (Wall) and Barbara Cookson (Egan) are fired. |
| Hamil Shahbazi | 22 September | Matthew Khan | A gay Muslim who makes himself homeless due to feeling as though he will bring shame upon his family and local community. Donna Tompson (Tanya Vital) calls his sister Nadira (Safiyya Ingar) and helps him to repair his relationship with his family. |
| Nadira Shahzabi | 22 September | Safiyya Ingar | The brother of Nahil (Matthew Khan) who is accepting of his homosexuality. |
| Donna Tompson | 22 September | Tanya Vital | A stand-up comedian who learns in her mid-40s that she is pregnant, despite paying for IVF for ten years with her ex. |
| Alan Cooper | 23 September | Zariah Bailey | Harpeet Khanna's (Gary Pillai) neighbour who has a physical altercation with him. |
| Harpreet Khanna | 23 September | Gary Pillai | Alan Cooper's (Zariah Bailey) neighbour who has a physical altercation with him. |
| Natalie Wright | 23 September | Rachael McGuinness | Harpreet Khanna's (Pillai) girlfriend who attempts to blackmail Alan Cooper (Bailey) after seeing the two fighting. |
| Carol Dougan | 27 September | Rebecca Raybone | The mother of recovering drug addict Jojo (Katherine Lea) who accuses her of stealing her dead father's watch. |
| Jojo Dougan | 27 September | Katherine Lea | A recovering drug addict who learns that her boyfriend, Kieran Coombes (Jack Lowe), has stolen her dead father's watch. |
| Kieran Coombes | 27 September | Jack Lowe | The boyfriend of Jojo Dougan (Lea) who steals her dead father's watch to fund their potential new home together. |
| Cora Thompson | 28 September | Madeleine Gray | A social media influencer who exposes Ruby K (Alicia Lai) online due to Ruby advertising a dubious beauty clinic to her followers. |
| Ruby K | 28 September | Alicia Lai | A popular social media influencer who gets exposed due to promoting a dubious beauty clinic that leaves Cora Thompson (Madelaine Gray) with health issues. |
| Isaac Lane | 28 September | Michael O'Reilly | Ruby K's (Lai) ex-boyfriend who is used by Cora Thompson (Gray) to get in contact with her. |
| Clive Hopper | 29 September–19 October | Jim Findley | The owner of a Caribbean café that rivals Makeda Sylvester's (Angela Wynter) café. The two form a short-lived romantic connection. |
| Charita Sharma | 29 September–17 November | Maya Soroya | Rob Hollins' (Walker) counsellor who talks to him about his PTSD. |
| Vikki Baxter | 29 September | Emily Aston | Killian's (Harry Wyatt) mother who receives parcels of food from the council that Daniel Granger (Chambers) deems to be nutritionally unbalanced. She is encouraged to visit a food bank. |
| Killian Baxter | 29 September | Harry Wyatt | Vikki's (Emily Aston) son who feels unwell due to not having a nutritional diet. |
| Robin Fenwick | 29 September | Mark Carlisle | The director of a company that provides food parcels to the local council. He offers Daniel Granger (Chambers) a job as his medical advisor, but Daniel informs him how unhealthy his food parcels are. |
| Rosie Statham | 30 September | Emma Stansfield | The mother of a 16-year-old who died after taking drugs at a party. She finds the family of the drug dealer, Amanda (Fiona Boylan) and Kellie Grant (Natalie Quarry), and informs them that their relative is responsible for her daughter's death. |
| Amanda Grant | 30 September | Fiona Boylan | The wife of a man who is imprisoned for dealing drugs. Her daughter, Kellie (Quarry), learns that Amanda knew of his dealings and involved herself in his operation. |
| Kellie Grant | 30 September | Natalie Quarry | The daughter of Amanda (Boylan) who learns that she was involved in a drug dealing operation led by her imprisoned father. |
| October ||||
| Olly Brockhurst | 4 October | Jake Graf | A transgender man who is not accepted by his mother, Helena (Susan Kyd). He learns not to care what Helena thinks and later proposes to his girlfriend, April Lewin (Rachel Adedeji). |
| Helena Brockhurst | 4 October | Susan Kyd | The mother of Olly (Jake Graf) who does not accept his gender transition and deadnames him. |
| April Lewin | 4 October | Rachel Adedeji | The girlfriend of Olly Brockhurst (Graf) who sees Luca McIntyre (McLaren) about the worsened state of Olly's depression. |
| Nicola Blake | 5 October | Eleanor Kirby | Feargal Lumsden's (John Middleton) neighbour who tries to get him to sign his garden over to her until she learns of Feargal's dementia. |
| Feargal Lumsden | 5 October | John Middleton | An elderly man with dementia who is put into a specialist care home by his daughter, Eileen (Tor Clark). |
| Eileen Lumsden | 5 October | Tor Clark | Feargal's (Middleton) daughter who looks into putting him into a specialist care home due to her busy work schedule. |
| Don Harris | 6 October | Terence Booth | A man who pretends to be suffering from dementia to garner company from Gemma Wilks (Charlotte Workman) and Ann Harris (Hayley Considine). |
| Gemma Wilks | 6 October | Charlotte Workman | A former carer who unofficially cares for Don Harris (Terence Booth). |
| Ann Harris | 6 October | Hayley Considine | The daughter of Don Harris (Booth) who apologises for rarely visiting him. |
| Cassie Clarke | 7 October | Bessie Coates | A university student recovering from cancer. After her throat becomes itchy, she becomes paranoid that her cancer has returned and becomes anxious. |
| Sian Bryce | 7 October | Georgia Bruce | Cassie Clarke's (Bessie Coates) flatmate who worries about her mental health. |
| Johnny Cartwright | 11 October | Nick Judge | A criminal who robs a bottle of alcohol from a shop. |
| PC Haldane Mason | 11 October | James S Barnes | A police officer who gives Johnny Cartwright (Nick Judge) an alibi. |
| PC Lucy Chiang | 11 October | Rebecca Yeo | A police constable who asks Emma Reid (Miles) about applying for Harriet Shelton's (Stenson) former job. |
| Kate Lodge | 12 October | Fiona Sagar | A pregnant patient of Ruhma Carter's (Patel) who hires an escort to act as her birthing partner. |
| Emie Hazel | 12 October | Gina Fillingham | A pregnant patient of Ruhma Carter's (Patel) who brings a hamster into her midwifery appointment as an emotional support animal. |
| Jake Sewell | 12 October | Adam Gillian | An escort that Kate Lodge (Fiona Sagar) hires to be her birthing partner. |
| Casey Matthews | 13–28 October | Caroline Head | A woman that Al Haskey (Midlane) believes he is talking to online. He later learns that he has been talking to Keith 'Starbuck' Dursley (Rufus Hound), an employee of Casey's. |
| Sgt Jacqui Lent | 13 October | Cal Freestone | A police officer that handles Morgan Scott's (Cora Kirk) case of sexual assault. |
| Morgan Scott | 13 October | Cora Kirk | A woman who is sexually assaulted by Jeremy Hyde (Alistair Kirton) after meeting him for coffee. |
| Tony Scott | 13 October | Craig Conway | The father of Morgan (Kirk) who worries about her welfare. |
| Jeremy Hyde | 13 October | Alistair Kirton | A man who sexually assaults Morgan Scott (Kirk) by holding her at knifepoint. |
| Aaron Brett | 14 October | Francis Johnson | The partner of Callum Leanord (David Bromley) who is confused when Callum shuts himself away. Callum later explains that he is trying to aid Aaron's feelings for when he dies, but Aaron explains that he wants to enjoy their lives together. |
| Callum Leonard | 14 October | David Bromley | The partner of Aaron Brett (Francis Johnson). Callum fears that he is dying and in response, shuts himself away from Aaron so that he is not as affected when he dies. |
| Kirsten Murray | 18 October | Pena Ilyambo | A trainee for the Royal Air Force who learns that she may have diabetes. |
| Abi Westwood | 18 October | Xsara-Sheneille Pryce | A friend of Kirsten Murray's (Pena Ilyambo) who was in the Royal Air Force. |
| Johnny Maguire | 19 October | Ethan Moorhouse | A former soldier who begins working at St. Phils Hospital as a cleaner after an injury in Afghanistan. |
| Dan Willis | 19 October | Joao Faulkner | The son of Trish (Savannah Stevens) who struggles with her having another child. |
| Trish Willis | 19 October | Savannah Stevens | A pregnant patient of Ruhma Carter's (Patel). |
| Darren Craven | 20 October | Theo Johnson | Three teenagers who hijack Sid Vere's (Rice) ambulance which has blood for a blood transplant inside. They take the blood and ask for money in return for it back, but run away when he is unable to pay. |
| Kim Chambers | 20 October | Emily Belcher | Three teenagers who hijack Sid Vere's (Rice) ambulance which has blood for a blood transplant inside. They take the blood and ask for money in return for it back, but run away when he is unable to pay. |
| Charlie Jones | 20 October | Dumo Mkweli | Three teenagers who hijack Sid Vere's (Rice) ambulance which has blood for a blood transplant inside. They take the blood and ask for money in return for it back, but run away when he is unable to pay. |
| David Sawyer | 21 October | Sean Knopp | A man with post partum psychosis. David takes his child away from his mother; she reports him as missing and the police find them. |
| Amira Mirza | 25 October | Halema Hussain | A girl that Shak Hanif (Sunjay Midda) attempts to impress. |
| Kamal Karimi | 25 October | Danish Latif | An ex-boyfriend of Amira Mirza's (Halema Hussain) that reveals to Shak Hanif (Midda) that he bankrupted himself by spending £5000 on Amira to impress her. |
| Ernie Lynn | 26 October | Paul Copley | A parking enforcement officer who fraudulently gives people at the Campus Surgery fake tickets that are paid to his own bank account. |
| Elsie Lynn | 26 October | Andria Doherty | The wife of Ernie (Paul Copley). |
| Heather Derby | 27 October | Jacqueline Boatswain | The mother of Rachel (Ruby Crepin-Glyne) and Bex (Shanice Archer). Her husband died of COVID-19 passed on to him by Bex. |
| Rachel Derby | 27 October | Ruby Crepin-Glyne | A university student who initially blames herself for the death of her father. She later learns that her sister Bex (Archer) gave him COVID-19. |
| Bex Derby | 27 October | Shanice Archer | A woman who learns that she passed COVID-19 onto her father. |
| Keith 'Starbuck' Dursley | 28 October–15 November | Rufus Hound | A man who Al Haskey (Midlane) talks to online. Al believes that Keith is a woman and is shocked to learn on their date that he is a man; the pair become friends instead. |
| Brenda Malachi-Jones | 28 October–4 November | Paddy Navin | The head of the committee for the Letherbridge Environmental Day. |
| November ||||
| Jenny Hoffman | 1 November | Eve Shotton | A woman who believes that having children is damaging to the environment; she later becomes pregnant but decides to keep the baby. |
| Jeremy Hoffman | 1 November | Daniel Boyd | A man who gets a vasectomy due to believing that having children is damaging to the environment. |
| Regan Hoffman | 1 November | Helen Pearson | The mother of Jeremy and Jenny who is elated to learn that she will be a grandmother. |
| Eliot Barnes | 1 November | Jarreau Antoine | A man who unsuccessfully auditions for Daniel Granger (Chambers) and Brenda Malachi-Jones (Paddy Navin) to be the lead actor of their environmental campaign. |
| Charly Stafford | 2 November | Timothy Harker | A non-binary patient of the Mill that explains to Karen Hollins (Pearson) that they have difficulty going out of the house. |
| Derek Kennedy | 2 November | Royce Cronin | A former student of Charly Stafford (Timothy Harker). |
| Benji Kennedy | 2 November | Billy Rilot | A teenager who gets tutoring from Charly Stafford (Harker). |
| Ellie Bolt | 3 November | Sydney Stevens | A girl who accidentally overdoses on her medication; Al Haskey (Midlane) informs her that her reaction is due to having grapefruit juice with her antidepressant medication. |
| Janet Bolt | 3 November | Diana Weston | The concerned mother of Ellie (Sydney Stevens). |
| Amy White | 4 November | Mollie Holder | Two students who reprimand Todd Jarrett (Josh Tedeku) for illegal dumping. |
| Jase Long | 4 November | Daniel Blacker | Two students who reprimand Todd Jarrett (Josh Tedeku) for illegal dumping. |
| Todd Jarrett | 4 November | Josh Tedeku | A painter who attempts to illegally dump old paint cans in a river. |
| Bernie Tanner | 8 November | Tom McCall | Sid Vere's (Rice) patient with deteriorating asthma. He finds that Bernie's worsening asthma is due to the flowers in his house. |
| Rosie Tanner | 8 November | Sophie Robinson | Bernie's (Tom McCall) wife. |
| Dr Christine Deng | 9–18 November | Kirsten Foster | The doctor overseeing Makeda Sylvester (Wynter) at St. Phils Hospital. |
| Jack Turner | 10 November | James Cartmell | A teenager who receives a heart transplant from Richard Waters' (Christopher Larkin) dead son. |
| Carl Turner | 10 November | Max Dowler | Jack's (James Cartmell) father who is distraught to learn he has stopped taking the medication prescribed for his heart transplant. |
| Richard Waters | 10 November | Christopher Larkin | The father of a teenager who dies; his heart is given to Jack Turner (Cartmell). |
| Lou Myers | 11 November | Rachel Flynn | A woman in an abusive relationship with Ross Jenkins (Chris Hoskins). After ending their relationship and a failed attempt to escape, Ross chases her upstairs and murders her. |
| Ross Jenkins | 11 November | Chris Hoskins | An abuser who murders his ex-girlfriend Lou Myers (Rachel Flynn). |
| Maud Southcliffe | 15 November | Marlene Sidaway | The grandmother of Kai (Kyle Rowe) who uses the cellar in her house to imprison Nataliya Kosenko (Maja Laskowska). |
| Kai Southcliffe | 15 November | Kyle Rowe | A man who imprisons Nataliya Kosenko (Laskowska) in his grandmother's cellar; he invites men over each night to pay to have sex with her until she escapes and his grandmother informs the police. |
| Nataliya Kosenko | 15 November | Maja Laskowska | A Ukrainian woman who was trafficked to England by Kai Southcliffe (Rowe); he locks her in a cellar and has men pay him to have sex with her. |
| Prof Phillip Whybrow | 16–18 November | Graham Hoadly | The head of the endoscopy unit at St. Phils Hospital. He assumes Bear Sylvester (Lee) is being aggressive due to him confronting Cathy Jenkins (Laura Bayston) on her racism and asks him to leave. |
| Cathy Jenkins | 16 November 2021, 7–15 June 2022 | Laura Bayston | A nurse at St. Phils Hospital who treats Makeda Sylvester (Wynter) poorly due to her being black. Her treatment discourages Makeda from receiving her endoscopy. Months later, she begins working at the Mill temporarily. When Bear learns of her employment, he informs the staff that Cathy is a racist, and they turn on her. Ruhma Carter (Patel) tries to show Cathy kindness, but after Ruhma informs her that she is not on her side, Cathy makes a racist comment and leaves. |
| Wojteck Walesa | 16 November | Christopher Jaciow | A security guard at St. Phils Hospital. He assumes that Bear Sylvester (Lee) is loitering in the hallways despite him explaining that he is there for his mother; he later removes him due to believing he is acting aggressively. |
| Sam Bailey | 17 November | Stuart Quigley | A university student with symptoms of schizophrenia. In an attempt to get prescription drugs, his friend, Johan Marsh (Tevye Matheson), pretends to be him at the surgery. |
| Johan Marsh | 17 November | Tevye Matheson | Sam Bailey's (Stuart Quigley) friend who pretends to be him in a consultation with Zara Carmichael (Walsh) to get prescription drugs. |
| Beth Rupani | 18 November | Victoria Moseley | A gambling addict. Her husband, Anish (David Kukadia), discovers that she has been gambling again and persuades her to get help from the Mill. |
| Sasha Rupani | 18 November | Duaa Karim | The teenage daughter of Beth (Victoria Moseley) and Anish (Kukadia) who is unaware of her mother's gambling addiction. |
| Anish Rupani | 18 November | David Kukadia | The husband of Beth (Moseley), a gambling addict. He discovers that she has been gambling again and persuades her to seek help from the Mill. |
| Meg Clarke | 22 November | Trudie Goodwin | The mother of Phil (Louis Tamone) who discovers that he is cheating on his girlfriend, Simone Paoli (Angelique Joan), who cares for Meg. |
| Simone Paoli | 22 November | Angelique Joan | The girlfriend of Phil Clarke (Tamone) who cares for his mother, Meg (Trudie Goodwin). |
| Phil Clarke | 22 November | Louis Tamone | The son of Meg (Goodwin). Meg discovers that he has been cheating on his girlfriend, Simone Paoli (Joan), and exposes him. |
| Mr Chesterman | 23 November | Mark Oosterveen | An administrator at St. Phils Hospital who responds to Bear Sylvester's (Lee) experiences with racism in the hospital. He suggests that Bear leads his forthcoming diversity initiative, but he refuses due to believing that as the victim of racism, he should not have to fix the hospital's racism issues. |
| Thomas Jacobsen | 23 November | Andrew Readman | A prison inmate who claims to have amnesia. Due to his experience with Karen Hollins' (Pearson) amnesia, Rob Hollins (Walker) recognises that Thomas does not have amnesia and is instead a missing person. |
| Kate Makinwa | 23 November | Helen Aluko | A police constable at Letherbridge Police Station who does not initially get on with Rob Hollins (Walker). |
| Doris James | 24 November | Gabrielle Lloyd | A woman who, during the COVID-19 pandemic, is surprised to is forced to shield from her son, Dennis (Robert Ewens), who has a learning disability, due to not being allowed to visit his care home. He later dies alone, which she blames herself for. |
| Dennis James | 24 November | Robert Ewens | The son of Doris (Gabrielle Lloyd) who dies alone during the COVID-19 pandemic. |
| Albert Vaughan | 24 November | Nigel Betts | The partner of Doris James (Lloyd), who he meets during the COVID-19 pandemic. The pair complete word searches together over the phone until they are able to safely meet. |
| Victor Oliver | 25 November–2 December | Graham Seed | An actor that Maggie Lynch (Alison Belbin) introduces to Karen Hollins (Pearson) to act as her boyfriend to make Rob Hollins (Walker) jealous. He forms real feelings for Karen and admits his admiration for her, but she affirms that she does not like him. |
| Stefan Vannier | 25 November | Jonathan Tafler | Method actors who pretend that Stefan has died and conjure a murder mystery. Luca MacIntyre (McLaren) is not informed that the investigation is fictional and is horrified to be accused of murdering Stefan, his patient. |
| Elizabeth Vannier | 25 November | Sophie Duval | Method actors who pretend that Stefan has died and conjure a murder mystery. Luca MacIntyre (McLaren) is not informed that the investigation is fictional and is horrified to be accused of murdering Stefan, his patient. |
| Joe Brasher | 25 November | Adrian Richards | Method actors who pretend that Stefan has died and conjure a murder mystery. Luca MacIntyre (McLaren) is not informed that the investigation is fictional and is horrified to be accused of murdering Stefan, his patient. |
| Ray Flask | 25 November | Adrian Christopher | A sky diving instructor who assists Laurence Richards (Rishard Beckett) and Sid Vere (Rice) with their sky dive. |
| Mike Kinsella | 29 November 2021, 14 June 2022, 11 March 2024 | Danny Szam | A detective sergeant who questions Chelsie Parks (LJ Johnson) and Rose Griffin (Fabienne Piolini-Castle) on a murder they have committed together. |
| Chelsie Parks | 29 November | LJ Johnson | A woman who is coerced into murdering a man with her best friend, Rose Griffin (Piolini-Castle). Despite Rose placing the blame on her, Chelsie does not expose Rose. |
| Rose Griffin | 29 November | Fabienne Piolini-Castle | A woman who coerces her best friend, Chelsie Parks (Johnson), into murdering a man. She then places the blame on Chelsie when questioned by Mike Kinsella (Danny Szam). |
| Conor Bradshaw | 30 November, 16 December | Jack O'Connor | A patient of Luca McIntyre's (McLaren) that sees him after contracting gonorrhoea after having sex with a man. He worries about getting HIV/AIDS from the encounter, so to assure him that people with HIV can lead healthy and full lives, Luca explains that he is HIV-positive and healthy, which Conor is disgusted by. He posts about Luca's HIV online, which is met with disgust from patients of the Mill. |
| Alice Eliot | 30 November | Lin Blakley | An activist who is convinced by her partner, Ruby Maynard (Sandy Walsh), to move her protesting online due to continuously risking her health. |
| Ruby Maynard | 30 November | Sandy Walsh | The partner of activist Alice Eliot (Lin Blakley) who convinces her to move her protesting online due to risking her health. |
| Drew Eliot | 30 November | Jake Kenny-Byrne | The grandson of Alice (Blakley) who joins her on protests. |
| December ||||
| Richie Crowther | 1 December | Jack Wilkinson | A man who becomes worried about his pregnant girlfriend, Jenny Davenport (Anna Elisabeth Mary Wright), when she searches through their belongings erratically. She later reveals that she meant to propose to him but that she has lost the ring. |
| Jenny Davenport | 1 December | Anna Elisabeth Mary Wright | A pregnant patient of Ruhma Carter's (Patel) who accuses restaurant owner Alfredo Cavalli (Joseph Long) of stealing her engagement ring. |
| Alfredo Cavalli | 1 December | Joseph Long | A restaurant owner who is accused of stealing Jenny Davenport's (Wright) engagement ring. |
| Mo Pemberton | 2 December | Debra Baker | A nervous patient of Sid Vere's (Rice) who refuses to be treated while Luca McIntyre (McLaren) is at the Mill due to his HIV+ status. Her colleague, Joni Tierney (Emma Bispham), explains that his HIV cannot be transmitted to her and persuades her to be treated. |
| Joni Tierney | 2 December | Emma Bispham | Mo Pemberton's (Debra Baker) colleague who explains that Luca McIntyre's (McLaren) HIV cannot be transmitted to her. |
| Nolan Whittle | 2 December | Sean McKenzie | The boss of Mo Pemberton (Baker) and Joni Tierney (Bispham). |
| Tony Lambert | 6–9 December | Dean Williamson | A man who protests at the Mill due to believing that Luca McIntyre's (McLaren) HIV is transmittable to patients. Al Haskey (Midlane) informs him that this is impossible and forces Tony to leave. |
| Andy Moore | 6 December | Dan Hagley | A delivery driver who gives Chelle Henry (Kevwe Emefe) a free dining table. |
| Sonia Okorie | 7 December | Princess Khumalo | A medical student at Letherbridge University who is scammed into taking a £12,000 unsecured loan by Fiona Edusei (Denise Laniyan). |
| Fiona Edusei | 7 December | Denise Laniyan | An international criminal who poses as a university student to scam students into investing in her business. |
| Trish Harland | 7 December | Laura Cairns | A student services staff member at Letherbridge University who plans to change the pastoral care procedures due to students having money struggles. |
| Lorna Hoskin | 8–13 December | Jessica Temple | A patient of Ruhma Carter's (Patel). |
| Nina Vincent | 8 December | Jilly Bond | The manipulative mother of Chloe (Imogen Wilde) who gaslights her into thinking she is a bad daughter. Sid Vere (Rice) notices and calls her behaviour out. |
| Chloe Vincent | 8 December | Imogen Wilde | The daughter of Nina (Jilly Bond) who, after Sid Vere (Rice) points it out, realises that her mother has been gaslighting her for as long as she can remember. |
| Frankie Clitheroe | 9 December | Ian Reddington | A ventriloquist who breaks his wrist after punching a wall. He worries about how he will perform his ventriloquism act due to his tour providing the majority of his revenue. |
| Toby Clitheroe | 9 December | Tyler Reddington | Frankie's (Ian Reddington) son who is tired of his father's ventriloquism act due to him spending the majority of his time on it. |
| Lee Bartley | 9 December | Daniel Reid-Walters | Imogen Hollins' (Charlie Clemmow) ex-boyfriend from school who she arranges to meet with. He confides in Imogen about the breakdown of his marriage to his wife and how he is being bullied at work. |
| Dorothy Cambridge | 13 December | Colette Zacca | Bear Sylvester's (Lee) aunt who learns that her mobile home is set to be towed due to damages on the vehicle that she cannot afford. Bear offers to pay for the fixes but she refuses to be in debt. Bear finds a stash of lottery tickets that Dorothy has collected and checks the numbers to find that she has won and can afford the repairs. |
| Ian Blackburn | 14 December | Jay Oliver Yip | A man with mental health issues who visits his children on the custody day. His wife phones the police and accuses him of breaking and entering. |
| Milly Wyndham | 15 December | Chloe Proctor | Doug Abbott's (Shaun Prendergast) daughter who refuses to invite him to the family Christmas celebrations due his alcoholism. |
| Doug Abbott | 15 December | Shaun Prendergast | A recovering alcoholic who has recently had a major bowel cancer surgery. His friend, Alan Ellis (Rowe David McClelland), encourages him to drink. |
| Alan Ellis | 15 December | Rowe David McClelland | Doug Abbott's (Prendergast) drinking friend. |
| Dominic Peters | 15 December | Stephen Leask | An overly keen mattress salesman who encourages Karen (Pearson) and Rob Hollins (Walker) to buy two mattresses from his shop. |
| Chris Walsh | 16 December | Nick Oliver | A security guard who Daniel Granger (Chambers) finds washing in the campus surgery toilets. He notifies Derek Selby (Patrick Brennan), the acting head of security, but then finds out that Chris is homeless and has been sleeping in the toilets. |
| Derek Selby | 16 December | Patrick Brennan | The acting head of security for Letherbridge University. |
| Sarah Walsh | 16 December | Evie Killip | Chris' (Oliver) pregnant wife. |