# 2021–22 Super League Greece 2

The 2021–22 Super League 2, known as Super League 2 betsson for sponsorship reasons, is the third season of the Super League 2, the second-tier Greek professional league for association football clubs, since the restructuring of the Greek football league system.
The season started on 6 November 2021 and ended in May 2022. The league will be conducted of 34 teams and two groups, this is due to the restructure and abolishment of the Football League. The league will also see the introduction of B Teams by Olympiacos, PAOK, AEK Athens and Panathinaikos. B Teams are ineligible for promotion and relegation.

## Team changes

The following teams have changed division since the 2020–21 season.
Panachaiki, Ialysos, Santorini 2020, Orfeas Xanthi, Doxa Drama, Panionios, withdrew from the championship.

### From Super League Greece 2

Promoted to Super League
* Ionikos
Relegated to Gamma Ethniki
* Panachaiki
* Doxa Drama

## North Group
### Teams

| Team | City | Stadium | Capacity |
| AEL | Larisa | Alcazar Stadium | 13,108 |
| Almopos Aridea | Aridaia | Aridea Municipal Stadium | 700 |
| Anagennisi Karditsa | Karditsa | Municipal Stadium Karditsa | 9,500 |
| Apollon Larissa | Larisa | Filippoupoli Stadium | 5,000 |
| Apollon Pontus | Thessaloniki | Kalamaria Stadium | 6,500 |
| Iraklis | Thessaloniki | Kaftanzoglio Stadium | 27,770 |
| Kavala | Kavala | Anthi Karagianni Stadium | 10,550 |
| Niki Volos | Volos | Panthessaliko Stadium | 22,700 |
| Olympiacos B | Piraeus | Tavros Stadium | 4,000 |
| Olympiacos Volos | Volos | Neapoli Volos Municipal Stadium | 2,500 |
| Panserraikos | Serres | Serres Municipal Stadium | 9,500 |
| PAOK B | Thessaloniki | Makedonikos Stadium | 8,100 |
| Pierikos | Katerini | Katerini Municipal Stadium | 4,995 |
| Thesprotos | Igoumenitsa | Municipal Stadium Igoumenitsa | 3,500 |
| Trikala | Trikala | Trikala Municipal Stadium | 15,000 |
| Veria | Veria | Veria Stadium | 7,000 |
| Xanthi | Xanthi | Xanthi FC Arena | 7,244 |

### Personnel and sponsoring

| Team | Manager | Captain | Kit manufacturer | Sponsor |
| AEL | Sotiris Antoniou | Manolis Bertos | Legea | Thrakis Gefseis |
| Almopos Aridea | Georgios Tyriakidis | Rafail Pettas | Errea | Loutra Pozar |
| Anagennisi Karditsa | Periklis Amanatidis | Nikos Golias | Nike | N/A |
| Apollon Larissa | Thomas Grafas | Konstantinos Chatzis | Givova | Psaragores Thalassa |
| Apollon Pontus | Dimitris Kalaitzidis | Dimitrios Amarantidis | Nike | N/A |
| Iraklis | Kostas Georgiadis | Manolis Papasterianos | Joma | N/A |
| Kavala | Panagiotis Dilberis | Giannis Kazantzidis | Macron | Ellagrolip |
| Niki Volos | Alekos Vosniadis | Manolis Apostolidis | Macron | Car.gr |
| Olympiacos B | Ariel Ibagaza | Giorgos Xenitidis | Adidas | Stoiximan |
| Olympiacos Volos | Timos Kavakas | Filippos Skopelitis | Nike | Mr. Pengu |
| Panserraikos | Giannis Giokas | Dimitris Anakoglou | Macron | Spyropoulos |
| PAOK B | Pablo García | Zisis Chatzistravos | Macron | Stoiximan |
| Pierikos | Georgios Vazakas | Konstantinos Demirtzoglou | Macron | N/A |
| Thesprotos | Juan Ramón Rocha | Charilaos Bikas | Nike | Car.gr |
| Trikala | Vasilis Kalogannis | Christos Niaros | Givova | LeChat |
| Veria | Pavlos Dermitzakis | Stelios Marangos | Nike | DaCristo |
| Xanthi | Konstantinos Anyfantakis | Anastasios Papazoglou | Joma | N/A |

### Managerial changes

| Team | Outgoing manager | Manner of departure | Date of vacancy | Position in table | Incoming manager | Date of appointment |
| Olympiacos B | — | — | — | Pre-season | Ariel Ibagaza | 12 June 2021 |
| PAOK B | — | — | — | Pre-season | Pablo Garcia | 19 July 2021 |
| Trikala | David Magrone | Resigned | 12 August 2021 | Pre-season | Leonidas Bilis | 13 August 2021 |
| AEL | Michalis Ziogas (caretaker) | End of tenure as caretaker | 23 May 2021 | Pre-season | Kostas Frantzeskos | 24 May 2021 |
| Apollon Larissa | Kostas Frantzeskos | Resigned | 23 May 2021 | Pre-season | Marcelo Straccia | 1 June 2021 |
| Xanthi | Babis Tennes | Resigned | 30 May 2021 | Pre-season | Jaime Monroy | 8 July 2021 |
| Olympiacos Volos | Vasilis Vouzas | Resigned | 13 July 2021 | Pre-season | Georgios Vazakas | 13 July 2021 |
| Iraklis | Thalis Theodoridis (caretaker) | End of tenure as caretaker | 2 August 2021 | Pre-season | Kostas Georgiadis | 2 August 2021 |
| Panserraikos | Giannis Giokas (caretaker) | End of tenure as caretaker | 2 August 2021 | Pre-season | Gerard Zaragoza | 2 August 2021 |
| Anagennisi Karditsa | Alexandros Kourtoglou | Resigned | 15 July 2021 | Pre-season | Periklis Amanatidis | 18 July 2021 |
| Trikala | Leonidas Bilis | Sacked | 16 September 2021 | Pre-season | Timos Kavakas | 16 September 2021 |
| AEL | Kostas Frantzeskos | Sacked | 13 October 2021 | Pre-season | Ilias Fyntanis | 14 October 2021 |
| Trikala | Timos Kavakas | Sacked | 8 November 2021 | 5th | Jorge Abente | 10 November 2021 |
| Xanthi | Jaime Monroy | Sacked | 12 November 2021 | 9th | Nikos Kehagias | 12 November 2021 |
| Olympiacos Volos | Georgios Vazakas | Sacked | 24 November 2021 | 8th | Manu Calleja | 25 November 2021 |
| Apollon Larissa | Marcelo Straccia | Sacked | 16 December 2021 | 16th | Thomas Grafas | 17 December 2021 |
| AEL | Ilias Fyntanis | Sacked | 23 December 2021 | 6th | Panagiotis Goutsidis | 23 December 2021 |
| Trikala | Jorge Abente | Sacked | 24 December 2021 | 10th | Nikos Oustabasidis | 24 December 2021 |
| Kavala | Nikos Karabiberis | End of contract | 31 December 2021 | 17th | Alexander Nouri | 1 January 2022 |
| Olympiacos Volos | Manu Calleja | Sacked | 1 January 2022 | 14th | Vasilis Vouzas | 1 January 2022 |
| Panserraikos | Gerard Zaragoza | Sacked | 2 January 2022 | 15th | Angelos Digozis | 2 January 2022 |
| Pierikos | Nikos Theodosiadis | Sacked | 16 January 2022 | 13th | Georgios Vazakas | 17 January 2022 |
| Xanthi | Nikos Kehagias | Resigned | 28 January 2022 | 3rd | Kostas Michailidis (caretaker) | 28 January 2022 |
| Xanthi | Kostas Michailidis (caretaker) | End of tenure as caretaker | 1 February 2022 | 3rd | Zoran Vulić | 1 February 2022 |
| Trikala | Nikos Oustabasidis | Resigned | 7 February 2022 | 10th | Timos Kavakas | 9 February 2022 |
| Trikala | Timos Kavakas | Resigned | 22 February 2022 | 14th | Vasilis Kalogannis (caretaker) | 22 February 2022 |
| Xanthi | Zoran Vulić | Sacked | 4 March 2022 | 4th | Konstantinos Anyfantakis | 8 March 2022 |
| Olympiacos Volos | Vasilis Vouzas | Sacked | 6 March 2022 | 16th | Timos Kavakas | 7 March 2022 |
| Kavala | Alexander Nouri | Resigned | 26 March 2022 | 17th | Georgios Angelidis (caretaker) | 26 March 2022 |
| Kavala | Georgios Angelidis (caretaker) | End of tenure as caretaker | 28 March 2022 | 17th | Nikos Karabiberis (caretaker) | 28 March 2022 |
| Kavala | Nikos Karabiberis (caretaker) | End of tenure as caretaker | 6 April 2022 | 15th | Panagiotis Dilberis (caretaker) | 6 April 2022 |
| Panserraikos | Angelos Digozis | Resigned | 14 April 2022 | 14th | Giannis Giokas (caretaker) | 14 April 2022 |
| AEL | Panagiotis Goutsidis | Resigned | 28 April 2022 | 2nd | Sotiris Antoniou | 3 May 2022 |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Promotion, qualification or relegation |
| 1 | Veria (Q) | 32 | 23 | 6 | 3 | 61 | 23 | +38 | 75 | Qualification for the Title and Promotion play-offs |
| 2 | AEL | 32 | 19 | 10 | 3 | 42 | 15 | +27 | 67 | |
| 3 | Xanthi (R) | 32 | 13 | 14 | 5 | 43 | 25 | +18 | 53 | Relegation to Local Championships |
| 4 | Niki Volos | 32 | 14 | 10 | 8 | 38 | 20 | +18 | 52 | |
| 5 | Anagennisi Karditsa | 32 | 15 | 6 | 11 | 47 | 34 | +13 | 51 | |
| 6 | Olympiacos B | 32 | 14 | 9 | 9 | 40 | 31 | +9 | 51 | |
| 7 | Iraklis | 32 | 11 | 15 | 6 | 51 | 29 | +22 | 48 | |
| 8 | PAOK B | 32 | 11 | 11 | 10 | 41 | 32 | +9 | 44 | |
| 9 | Almopos Aridea | 32 | 10 | 9 | 13 | 40 | 39 | +1 | 39 | |
| 10 | Apollon Pontus | 32 | 9 | 10 | 13 | 34 | 38 | −4 | 37 | |
| 11 | Apollon Larissa | 32 | 8 | 11 | 13 | 27 | 42 | −15 | 35 | |
| 12 | Thesprotos | 32 | 8 | 10 | 14 | 34 | 43 | −9 | 34 | |
| 13 | Panserraikos | 32 | 7 | 12 | 13 | 31 | 39 | −8 | 33 | |
| 14 | Pierikos (R) | 32 | 7 | 11 | 14 | 36 | 49 | −13 | 32 | Relegation to Gamma Ethniki |
| 15 | Kavala (R) | 32 | 7 | 10 | 15 | 25 | 71 | −46 | 31 | Relegation to Gamma Ethniki |
| 16 | Olympiacos Volos (R) | 32 | 7 | 8 | 17 | 34 | 49 | −15 | 29 | Relegation to Gamma Ethniki |
| 17 | Trikala (R) | 32 | 5 | 6 | 21 | 17 | 62 | −45 | 21 | Relegation to Gamma Ethniki |
* ↑ Olympiacos B and PAOK B are ineligible for promotion and relegation
* ↑ Xanthi was relegated to local championships because of financial problems.

### Results

| Home \ Away | AEL | ALM | ANK | APL | APP | IRA | KAV | NKV | OLB | OLV | PNS | PKB | PIE | THE | TRI | VER | XNT |
| AEL | — | 2–1 | 0–0 | 2–0 | 0–0 | 3–0 | 3–0 | 1–0 | 2–1 | 0–0 | 2–0 | 0–0 | 1–0 | 1–0 | 3–0 | 1–1 | 4–0 |
| Almopos Aridea | 0–1 | — | 1–0 | 2–2 | 2–0 | 0–2 | 1–1 | 0–0 | 3–0 | 0–0 | 0–1 | 1–2 | 3–1 | 1–0 | 3–0 | 1–2 | 2–2 |
| Anagennisi Karditsa | 2–3 | 4–0 | — | 1–0 | 2–1 | 0–3 | 1–0 | 0–0 | 0–1 | 4–0 | 1–0 | 1–0 | 2–0 | 1–0 | 4–2 | 5–2 | 4–0 |
| Apollon Larissa | 0–2 | 1–1 | 2–1 | — | 0–2 | 0–1 | 0–1 | 1–0 | 2–2 | 1–1 | 1–0 | 2–1 | 0–0 | 2–1 | 3–3 | 0–1 | 0–0 |
| Apollon Pontus | 1–3 | 1–1 | 1–1 | 1–1 | — | 1–1 | 7–0 | 0–0 | 0–0 | 1–0 | 1–0 | 0–3 | 1–0 | 0–0 | 3–0 | 0–0 | 0–0 |
| Iraklis | 1–1 | 6–0 | 1–1 | 4–0 | 0–3 | — | 1–2 | 0–0 | 0–0 | 4–0 | 1–1 | 0–0 | 4–2 | 6–0 | 0–1 | 1–0 | 1–0 |
| Kavala | 0–1 | 0–6 | 3–1 | 0–0 | 3–0 | 1–1 | — | 0–2 | 0–0 | 0–5 | 2–2 | 1–1 | 1–2 | 1–1 | 1–0 | 0–2 | 0–6 |
| Niki Volos | 1–1 | 1–0 | 1–0 | 0–2 | 1–0 | 1–1 | 7–0 | — | 0–1 | 1–0 | 1–0 | 2–1 | 2–0 | 3–1 | 3–0 | 2–2 | 0–1 |
| Olympiacos B | 1–0 | 2–1 | 0–1 | 0–1 | 2–0 | 0–0 | 2–2 | 2–0 | — | 3–2 | 2–1 | 3–1 | 3–0 | 4–0 | 2–0 | 1–1 | 1–1 |
| Olympiacos Volos | 1–2 | 1–1 | 0–1 | 2–1 | 3–2 | 1–1 | 0–2 | 1–2 | 2–3 | — | 1–2 | 3–1 | 0–1 | 0–1 | 2–0 | 0–2 | 1–0 |
| Panserraikos | 0–1 | 1–3 | 2–1 | 1–0 | 2–4 | 2–0 | 2–0 | 0–0 | 4–0 | 2–2 | — | 1–2 | 1–1 | 2–2 | 1–1 | 0–1 | 0–0 |
| PAOK B | 2–0 | 0–1 | 2–1 | 3–0 | 2–1 | 0–0 | 1–1 | 2–2 | 1–0 | 2–1 | 1–1 | — | 1–1 | 0–0 | 3–0 | 1–2 | 0–1 |
| Pierikos | 0–0 | 2–2 | 2–2 | 3–2 | 1–0 | 2–2 | 7–0 | 0–3 | 1–2 | 2–2 | 1–1 | 0–0 | — | 0–3 | 3–0 | 2–1 | 1–1 |
| Thesprotos | 0–0 | 0–3 | 0–0 | 1–1 | 1–2 | 1–5 | 7–0 | 2–0 | 2–1 | 1–1 | 3–0 | 1–1 | 1–0 | — | 2–0 | 1–3 | 0–0 |
| Trikala | 0–1 | 1–0 | 0–3 | 0–1 | 2–0 | 0–0 | 0–2 | 0–3 | 0–0 | 1–2 | 1–1 | 0–6 | 1–0 | 2–1 | — | 1–2 | 1–1 |
| Veria | 1–1 | 1–0 | 2–0 | 5–1 | 5–0 | 3–1 | 2–1 | 1–0 | 1–0 | 3–0 | 3–0 | 2–1 | 4–1 | 2–1 | 1–0 | — | 0–0 |
| Xanthi | 2–0 | 2–0 | 5–2 | 0–0 | 2–1 | 3–3 | 0–0 | 0–0 | 2–1 | 2–0 | 0–0 | 3–0 | 3–0 | 1–0 | 5–0 | 0–3 | — |

## South Group
### Teams

| Team | City | Stadium | Capacity |
| AEK Athens B | Spata | Spata Training Centre | 3,000 |
| A.E. Kifisia | Kifissia | Municipal Kifisia Stadium | 1,050 |
| Asteras Vlachioti | Vlachiotis | Vlachiotis Municipal Stadium | 600 |
| Chania | Chania | Perivolia Municipal Stadium | 4,527 |
| Diagoras | Rhodes | Diagoras Stadium | 3,700 |
| Egaleo | Aigaleo | Stavros Mavrothalassitis Stadium | 8,217 |
| Episkopi | Lappa | Gallos Stadium | 1,500 |
| Ergotelis | Heraklion | Pankritio Stadium | 26,240 |
| O.F. Ierapetra | Ierapetra | Ierapetra Municipal Stadium | 3,000 |
| Irodotos | Heraklion | Municipal Nea Alikarnassos Stadium | 3,000 |
| Kalamata | Kalamata | Kalamata Municipal Stadium | 5,613 |
| Kallithea | Kallithea | Grigoris Lambrakis Stadium | 6,300 |
| Karaiskakis | Arta | Municipal Agioi Anargiroi Stadium | 1,900 |
| Levadiakos | Livadeia | Levadia Municipal Stadium | 5,915 |
| Panathinaikos B | Athens | Grigoris Lambrakis Stadium | 6,300 |
| Rodos | Rhodes | Diagoras Stadium | 3,693 |
| Zakynthos | Zakynthos | Zakynthians Olympic Champions Ground | 2,000 |

### Personnel and sponsoring

| Team | Manager | Captain | Kit manufacturer | Sponsor |
| AEK Athens B | Nikos Panagiotaras | Christos Giousis | Nike | OPAP |
| A.E. Kifisia | Dimitrios Eleftheropoulos | Vangelis Gotovos | Macron | Peugeot Besikos |
| Asteras Vlachioti | Ilias Fyntanis | Markos Dounis | Zeus | N/A |
| Chania | Nikos Papadopoulos | Kostas Panagiotoudis | Saller | Mare Magnum |
| Diagoras | Giannis Providas | Konstantinos Rougalas | Nike | Bread Factory |
| Egaleo | Apostolos Charalampidis | Ilias Tsiligiris | Macron | Kyriakoulis |
| Episkopi | Jasminko Velić | Dimitris Polychronis | Lotto | Avin |
| Ergotelis | Nikos Badimas | Antonis Bourselis | Capelli | N/A |
| O.F. Ierapetra | Staikos Vergetis | Kaloudis Lemonis | Macron | N/A |
| Irodotos | Vasilios Vouzas | Manolis Roussakis | Stanno | N/A |
| Kalamata | Arjan Bellaj (caretaker) | Panagiotis Konstantinopoulos | Capelli | Volterra |
| Kallithea | Leonidas Vokolos | Mattheos Maroukakis | Zeus | N/A |
| Karaiskakis | Nikos Oustabasidis | Alexandros Bekatoros | Macron | Kotopoula Artas |
| Levadiakos | Giannis Taousianis | Alfredo Mejía | Legea | Kompotis |
| Panathinaikos B | Javier Vázquez | Andreas Athanasakopoulos | Kappa | N/A |
| Rodos | Nikos Kourbanas | Georgios Delaportas | Nike | Mitsis Hotels |
| Zakynthos | Dimitris Nolis | Giannis Kallivokas | Nike | N/A |

### Managerial changes

| Team | Outgoing manager | Manner of departure | Date of vacancy | Position in table | Incoming manager | Date of appointment |
| Panathinaikos B | — | — | — | Pre-season | Giannis Vonortas | 25 June 2021 |
| AEK Athens B | — | — | — | Pre-season | Sokratis Ofrydopoulos | 16 July 2021 |
| Levadiakos | Sokratis Ofrydopoulos (caretaker) | End of tenure as caretaker | 26 May 2021 | Pre-season | Giannis Taousianis | 18 June 2021 |
| Ergotelis | Giannis Taousianis | Resigned | 17 June 2021 | Pre-season | Nikos Badimas | 24 June 2021 |
| O.F. Ierapetra | Timos Kavakas | Resigned | 21 June 2021 | Pre-season | Staikos Vergetis | 1 July 2021 |
| Karaiskakis | Giannis Mangos | Resigned | 3 August 2021 | Pre-season | Dragan Đukanović | 4 August 2021 |
| Irodotos | Manolis Skyvalos | Resigned | 17 August 2021 | Pre-season | Giannis Tatsis | 21 August 2021 |
| Asteras Vlachioti | Panagiotis Goutsidis | Resigned | 23 September 2021 | Pre-season | Kostas Velitzelos | 25 September 2021 |
| Karaiskakis | Dragan Đukanović | Sacked | 23 December 2021 | 11th | Timos Kavakas | 23 December 2021 |
| Diagoras | Theodosis Theodosiadis | Sacked | 27 December 2021 | 13th | Giannis Providas | 28 December 2021 |
| Panathinaikos B | Giannis Vonortas | Sacked | 17 January 2022 | 9th | Javier Vázquez | 18 January 2022 |
| A.E. Kifisia | Nikos Koustas | Sacked | 18 January 2022 | 10th | Dimitrios Eleftheropoulos | 20 January 2022 |
| Karaiskakis | Timos Kavakas | Sacked | 2 February 2022 | 14th | Kostas Frantzeskos | 3 February 2022 |
| Irodotos | Giannis Tatsis | Resigned | 4 February 2022 | 16th | Dimitris Trivizadakis (caretaker) | 4 February 2022 |
| Kalamata | Nikos Anastopoulos | Resigned | 7 February 2022 | 4th | Arjan Bellaj (caretaker) | 7 February 2022 |
| Irodotos | Dimitris Trivizadakis (caretaker) | End of tenure as caretaker | 7 February 2022 | 16th | Ilias Fyntanis | 7 February 2022 |
| Rodos | Sotiris Antoniou | Sacked | 22 February 2022 | 12th | Giorgos Koltzos (caretaker) | 22 February 2022 |
| AEK Athens B | Sokratis Ofrydopoulos | Promoted to first team | 1 March 2022 | 6th | Nikos Panagiotaras | 1 March 2022 |
| Rodos | Giorgos Koltzos (caretaker) | End of tenure as caretaker | 7 March 2022 | 13th | Giannis Chatzinikolaou | 7 March 2022 |
| Irodotos | Ilias Fyntanis | Resigned | 10 March 2022 | 15th | Vasilis Vouzas | 12 March 2022 |
| Asteras Vlachioti | Kostas Velitzelos | Sacked | 16 March 2022 | 16th | Ilias Fyntanis | 18 March 2022 |
| Rodos | Giannis Chatzinikolaou | Resigned | 1 April 2022 | 17th | Nikos Kourbanas | 2 April 2022 |
| Karaiskakis | Kostas Frantzeskos | Sacked | 9 April 2022 | 14th | Theodoros Kantas (caretaker) | 9 April 2022 |
| Karaiskakis | Theodoros Kantas (caretaker) | End of tenure as caretaker | 13 April 2022 | 15th | Nikos Oustabasidis | 13 April 2022 |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Promotion, qualification or relegation |
| 1 | Levadiakos (Q) | 32 | 22 | 6 | 4 | 68 | 19 | +49 | 72 | Qualification for the Title and Promotion play-offs |
| 2 | Kallithea | 32 | 19 | 8 | 5 | 46 | 19 | +27 | 65 | |
| 3 | Kalamata | 32 | 19 | 7 | 6 | 51 | 20 | +31 | 61 | |
| 4 | Chania | 32 | 14 | 13 | 5 | 46 | 25 | +21 | 55 | |
| 5 | AEK Athens B | 32 | 14 | 10 | 8 | 38 | 27 | +11 | 52 | |
| 6 | A.E. Kifisia | 32 | 15 | 5 | 12 | 37 | 31 | +6 | 50 | |
| 7 | Episkopi | 32 | 13 | 9 | 10 | 27 | 25 | +2 | 48 | |
| 8 | Egaleo | 32 | 13 | 7 | 12 | 31 | 31 | 0 | 46 | |
| 9 | Ergotelis (R) | 32 | 11 | 7 | 14 | 23 | 32 | −9 | 40 | Relegation to Local Championships |
| 10 | O.F. Ierapetra | 32 | 10 | 7 | 15 | 43 | 49 | −6 | 37 | |
| 11 | Irodotos | 32 | 10 | 7 | 15 | 29 | 42 | −13 | 37 | |
| 12 | Diagoras | 32 | 9 | 9 | 14 | 22 | 36 | −14 | 36 | |
| 13 | Asteras Vlachioti (R) | 32 | 9 | 8 | 15 | 32 | 38 | −6 | 35 | Relegation to Local Championships |
| 14 | Panathinaikos B | 32 | 9 | 7 | 16 | 28 | 40 | −12 | 34 | |
| 15 | Karaiskakis (R) | 32 | 7 | 8 | 17 | 24 | 50 | −26 | 29 | Relegation to Local Championships |
| 16 | Rodos (R) | 32 | 8 | 6 | 18 | 27 | 48 | −21 | 18 | Relegation to Gamma Ethniki |
| 17 | Zakynthos (R) | 32 | 5 | 6 | 21 | 19 | 61 | −42 | 12 | Relegation to Gamma Ethniki |
* ↑ AEK Athens B and Panathinaikos B are ineligible for promotion and relegation
* ↑ Kalamata has 3 points deducted, from the HFF.
* ↑ Ergotelis was relegated to local championships because of financial problems.
* ↑ Asteras Vlachioti was relegated to local championships because of financial problems.
* ↑ Karaiskakis was relegated to local championships because of financial problems.
* ↑ Rodos has 12 points deducted, from the HFF.
* ↑ Zakynthos has 9 points deducted, from the HFF.

### Results

| Home \ Away | AKB | AVL | CHA | DGR | EGA | EPK | ERG | IRO | KAL | KLT | KAR | KIF | LEV | OFI | PTB | ROD | ZAK |
| AEK Athens B | — | 1–0 | 1–0 | 0–1 | 1–1 | 1–0 | 1–1 | 3–1 | 1–0 | 0–3 | 2–1 | 2–2 | 2–1 | 2–2 | 0–1 | 5–0 | 1–0 |
| Asteras Vlachioti | 1–1 | — | 0–0 | 2–0 | 2–1 | 0–0 | 4–0 | 1–3 | 0–0 | 0–2 | 1–1 | 0–1 | 1–2 | 4–1 | 3–1 | 0–0 | 3–0 |
| Chania | 2–1 | 3–1 | — | 2–0 | 1–0 | 1–0 | 0–0 | 0–0 | 1–2 | 0–0 | 4–0 | 3–0 | 3–1 | 2–0 | 2–0 | 2–2 | 5–1 |
| Diagoras | 0–1 | 2–0 | 2–2 | — | 1–1 | 1–0 | 0–2 | 1–1 | 0–1 | 0–0 | 0–1 | 0–2 | 1–1 | 0–0 | 1–2 | 1–0 | 2–0 |
| Egaleo | 1–1 | 1–0 | 1–1 | 1–2 | — | 1–1 | 2–0 | 2–0 | 1–2 | 0–0 | 1–0 | 1–0 | 1–2 | 2–0 | 2–1 | 3–1 | 2–1 |
| Episkopi | 1–3 | 0–1 | 1–1 | 1–0 | 1–1 | — | 1–0 | 1–0 | 0–0 | 1–1 | 0–1 | 1–0 | 0–0 | 0–1 | 3–2 | 4–2 | 1–0 |
| Ergotelis | 0–0 | 0–0 | 0–0 | 0–1 | 1–0 | 1–0 | — | 0–1 | 2–0 | 0–2 | 0–0 | 2–1 | 1–0 | 1–3 | 1–0 | 0–1 | 1–0 |
| Irodotos | 1–0 | 2–1 | 2–2 | 1–2 | 3–0 | 0–1 | 1–2 | — | 2–1 | 0–2 | 0–0 | 3–2 | 0–1 | 2–1 | 0–0 | 0–0 | 2–0 |
| Kalamata | 0–0 | 1–0 | 1–1 | 2–0 | 3–0 | 5–0 | 2–0 | 2–0 | — | 2–2 | 2–0 | 0–1 | 1–0 | 4–0 | 1–2 | 3–1 | 5–0 |
| Kallithea | 1–0 | 5–1 | 3–1 | 1–0 | 1–0 | 0–2 | 3–2 | 3–0 | 0–0 | — | 4–2 | 1–0 | 0–1 | 1–2 | 1–0 | 2–0 | 2–0 |
| Karaiskakis | 0–1 | 0–1 | 1–2 | 0–0 | 3–1 | 0–0 | 3–2 | 2–1 | 0–1 | 1–0 | — | 0–2 | 0–3 | 2–3 | 1–1 | 2–1 | 0–2 |
| A.E. Kifisia | 2–1 | 2–1 | 1–0 | 0–0 | 1–0 | 0–1 | 1–2 | 2–0 | 1–2 | 1–0 | 0–0 | — | 1–4 | 2–1 | 2–0 | 1–0 | 3–0 |
| Levadiakos | 2–2 | 2–1 | 1–1 | 4–0 | 1–0 | 1–0 | 1–0 | 6–0 | 3–0 | 1–1 | 3–0 | 1–1 | — | 3–1 | 3–0 | 5–0 | 4–0 |
| O.F. Ierapetra | 1–2 | 3–1 | 0–0 | 2–2 | 0–1 | 0–1 | 1–2 | 1–1 | 0–2 | 1–2 | 5–1 | 2–1 | 0–1 | — | 2–0 | 1–1 | 5–1 |
| Panathinaikos B | 0–2 | 2–0 | 0–2 | 3–0 | 0–1 | 1–2 | 0–0 | 1–2 | 1–2 | 0–0 | 2–2 | 1–0 | 1–3 | 3–1 | — | 3–0 | 1–1 |
| Rodos | 1–0 | 0–1 | 0–1 | 3–0 | 0–1 | 0–0 | 1–0 | 1–0 | 0–3 | 0–1 | 3–0 | 1–3 | 0–4 | 1–2 | 0–0 | — | 4–0 |
| Zakynthos | 0–0 | 1–1 | 3–1 | 0–2 | 0–1 | 0–3 | 2–0 | 1–0 | 1–1 | 1–2 | 2–0 | 1–1 | 0–3 | 1–1 | 0–1 | 0–3 | — |
* ↑ The game awarded a 3–0 w/o win to Asteras Vlachioti.
* ↑ Originally finished 0-0. Levadiakos made appeal and the game forfeited 3-0, because Kalamata's players had expired health cards.
* ↑ The game awarded a 0–3 w/o win to Levadiakos.
* ↑ Originally finished 5-0. Rodos made appeal and the game forfeited 0-3, because Zakynthos used fewer Greek footballers than the number provided in the announcement of the championship.

## Title and promotion play-offs

Veria and Levadiakos played a 2 game title play-off on 8 and 15 May 2022.

## Top scorers

    As of 1 May 2022
24 goals
* Giannis Pasas (Veria)
21 goals
* Giannis Loukinas (Kalamata)
20 goals
* Christos Rovas (Almopos Aridea)
17 goals
* Hicham Kanis (Panserraikos)
* Admir Bajrovic (Chania)
* Christos Giousis (AEK Athens B)
* Anthony Mounier (Kallithea)
15 goals
* Alexandros Arnarellis (Egaleo)
14 goals
* Marios Ogkmpoe (AEL)
12 goals
* Nicolás Andereggen (O.F. Ierapetra)
11 goals
* Nili (Levadiakos)
* Andreas Vasilogiannis (Chania)
* Andrews Tetteh (A.E. Kifisia)
10 goals
* Theocharis Pozatzidis (Kallithea/Irodotos)
* Apostolos Sarantidis (Thesprotos)
* Dimitrios Diamantopoulos (Xanthi)
* Georgios Koutsias (PAOK B)
* Rooney Wankewai (Karaiskakis/Apollon Pontou)
* Mathías Tomás (Iraklis)
* Alexis Messidoro (O.F. Ierapetra)
9 goals
* Donaldoni Zambou Nguemechieu (Karaiskakis)
* Nestoras Mytidis (Levadiakos)
* Panagiotis Kynigopoulos (Kallithea)
8 goals
* Petros Giakoumakis (Veria)
* Lucas Poletto (Levadiakos)
* Tyrone Conraad (Ergotelis)
* Bogdan Stamenković (Kavala)
* Wilson Chimeli (Zakynthos)
* Tharcysio (Episkopi)
* Miguel Bianconi (Anagennisi Karditsa)
* Denzel Jubitana (Iraklis)