# 1988 Virginia Slims of Indianapolis – Singles

Halle Cioffi was the defending champion but lost in the second round to Gretchen Magers.
Katerina Maleeva won in the final 6–3, 2–6, 6–2 against Zina Garrison.

## Seeds

A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
* Zina Garrison (final)
* Katerina Maleeva (champion)
* Stephanie Rehe (semifinals)
* Larisa Savchenko (second round)
* Helen Kelesi (first round)
* Anne Minter (first round)
* Halle Cioffi (second round)
* Leila Meskhi (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking
| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Z Garrison | 7 | 6 | | | | | | | | | | | | | | | | | | | | |
| | K Schimper | 6 | 1 | | 1 | Z Garrison | 6 | 6 | | | | | | | | | | | | | | | |
| | S Parkhomenko | 4 | 6 | 2 | | N Bykova | 0 | 3 | | | | | | | | | | | | | | | |
| | N Bykova | 6 | 4 | 6 | | | | | | 1 | Z Garrison | 6 | 7 | | | | | | | | | | |
| | R Fairbank | 7 | 6 | | | | | | | | H Na | 1 | 6 | | | | | | | | | | |
| Q | S Stafford | 5 | 3 | | | R Fairbank | 1 | 1 | | | | | | | | | | | | | | | |
| | H Na | 7 | 7 | | | H Na | 6 | 6 | | | | | | | | | | | | | | | |
| 8 | L Meskhi | 6 | 6 | | | | | | | | | | | | 1 | Z Garrison | 6 | 6 | | | | | |
| 4 | L Savchenko | 6 | 6 | 6 | | | | | | | | | | | Q | L Allen | 3 | 4 | | | | | |
| | J Mundel | 3 | 7 | 0 | 4 | L Savchenko | 1 | 6 | 2 | | | | | | | | | | | | | | |
| LL | B Herr | 6 | 2 | 2 | Q | L Allen | 6 | 2 | 6 | | | | | | | | | | | | | | |
| Q | L Allen | 4 | 6 | 6 | | | | | | Q | L Allen | 6 | 6 | | | | | | | | | | |
| | R Reis | 6 | 6 | | | | | | | Q | S Martin | 3 | 1 | | | | | | | | | | |
| Q | L Gregory | 3 | 2 | | | R Reis | 3 | 2 | | | | | | | | | | | | | | | |
| Q | S Martin | 6 | 6 | | Q | S Martin | 6 | 6 | | | | | | | | | | | | | | | |
| 6 | A Minter | 3 | 4 | | | | | | | | | | | | | | | | 1 | Zina Garrison | 3 | 6 | 2 |
| 7 | H Cioffi | 6 | 6 | | | | | | | | | | | | | | | | 2 | Katerina Maleeva | 6 | 2 | 6 |
| | A Kijimuta | 1 | 3 | | 7 | H Cioffi | 1 | 4 | | | | | | | | | | | | | | | |
| | S Reece | 2 | 3 | | | G Magers | 6 | 6 | | | | | | | | | | | | | | | |
| | G Magers | 6 | 6 | | | | | | | | G Magers | 7 | 3 | 4 | | | | | | | | | |
| | M L Daniels | 6 | 6 | 6 | | | | | | 3 | S Rehe | 5 | 6 | 6 | | | | | | | | | |
| | E Burgin | 7 | 3 | 4 | | M L Daniels | 1 | 4 | | | | | | | | | | | | | | | |
| | B Bowes | 6 | 1 | 4 | 3 | S Rehe | 6 | 6 | | | | | | | | | | | | | | | |
| 3 | S Rehe | 3 | 6 | 6 | | | | | | | | | | | 3 | S Rehe | 2 | 0 | | | | | |
| 5 | H Kelesi | 5 | 4 | | | | | | | | | | | | 2 | K Maleeva | 6 | 6 | | | | | |
| | A Frazier | 7 | 6 | | | A Frazier | 6 | 6 | | | | | | | | | | | | | | | |
| | M Werdel | 6 | 6 | | | M Werdel | 1 | 2 | | | | | | | | | | | | | | | |
| | I Kuczyńska | 4 | 4 | | | | | | | | A Frazier | 6 | 2 | 2 | | | | | | | | | |
| | A Grossman | 6 | 6 | | | | | | | 2 | K Maleeva | 2 | 6 | 6 | | | | | | | | | |
| | M Torres | 2 | 4 | | | A Grossman | 6 | 6 | 6 | | | | | | | | | | | | | | |
| | A Henricksson | 3 | 7 | 3 | 2 | K Maleeva | 7 | 4 | 7 | | | | | | | | | | | | | | |
| 2 | K Maleeva | 6 | 6 | 6 | | | | | | | | | | | | | | | | | | | |