# 2021 Buffalo Bills season

The 2021 season was the Buffalo Bills' 52nd in the National Football League (NFL), seventh full under the ownership of Terry and Kim Pegula, and their fifth under the head coach/general manager tandem of Sean McDermott and Brandon Beane.
Although unable to match their 13–3 record from the previous season, the Bills clinched the AFC East for a second consecutive year, their first consecutive division title since 1991. They finished the regular season at 11–6 to obtain the #3 seed for the playoffs, also marking their third consecutive postseason berth and fourth in five years. Statistically, the Bills had the No. 1-ranked defense, as well as the highest point differential and margin of victory. All of the team's victories were by multiple possessions, but they lost every game that was within one possession.
The Bills defeated their AFC East rival New England Patriots in the wild card round, a game marked by them becoming the first NFL team to score a touchdown on every offensive drive. Facing the Kansas City Chiefs in a Divisional Round matchup, the Bills lost amid a quarterback duel between Buffalo's Josh Allen and Kansas City's Patrick Mahomes. Although the Bills were able to take a three-point lead with 13 seconds remaining, the Chiefs scored a game-tying field goal on their following drive and won in overtime, with Josh Allen and the Bills' offense never getting to touch the ball in overtime. The defeat marked the second consecutive year the Bills were eliminated by the Chiefs.
The season also saw Pittsburgh-based health insurance company Highmark purchase the rights to the Bills' stadium, resulting in it being named Highmark Stadium.

## Draft

2021 Buffalo Bills Draft :
| Round | Selection | Player | Position | College | Notes |
| 1 | 30 | Gregory Rousseau | DE | Miami (FL) | Opted out of the 2020 CFB season while at the University of Miami |
| 2 | 61 | Carlos Basham Jr. | DE | Wake Forest | |
| 3 | 93 | Spencer Brown | OT | Northern Iowa | |
| 5 | 161 | Tommy Doyle | OT | Miami (OH) | from Las Vegas |
| 6 | 203 | Marquez Stevenson | WR | Houston | from Washington via Las Vegas and Miami and Houston |
| 6 | 212 | Damar Hamlin | S | Pittsburgh | from New Orleans via Houston |
| 6 | 213 | Rachad Wildgoose | CB | Wisconsin | |
| 7 | 236 | Jack Anderson | OG | Texas Tech | from Carolina |
Notes
* The Bills received a fifth-round selection from the Las Vegas Raiders in exchange for wide receiver Zay Jones.
* The Bills got a conditional seventh-round selection from the Carolina Panthers in exchange for offensive tackle Marshall Newhouse.
* ↑ Scott, Jelani (October 7, 2019). "Bills deal WR Zay Jones to Raiders for 2021 pick". NFL.com. Retrieved March 12, 2021.
* ↑ Strickland, Bryan (September 25, 2018). "Panthers trade for OT Marshall Newhouse". Panthers.com.

## Preseason

The Bills preseason schedule was announced on May 12. They opened the preseason with a 16–15 road win against the Detroit Lions.
| Week | Date | Opponent | Result | Record | Venue | Recap |
| 1 | August 13 | at Detroit Lions | W 16–15 | 1–0 | Ford Field | Recap |
| 2 | August 21 | at Chicago Bears | W 41–15 | 2–0 | Soldier Field | Recap |
| 3 | August 28 | Green Bay Packers | W 19–0 | 3–0 | Highmark Stadium | Recap |

## Regular season
### Schedule

The Bills 2021 schedule was announced on May 12.
| Week | Date | Opponent | Result | Record | Venue | Recap |
| 1 | September 12 | Pittsburgh Steelers | L 16–23 | 0–1 | Highmark Stadium | Recap |
| 2 | September 19 | at Miami Dolphins | W 35–0 | 1–1 | Hard Rock Stadium | Recap |
| 3 | September 26 | Washington Football Team | W 43–21 | 2–1 | Highmark Stadium | Recap |
| 4 | October 3 | Houston Texans | W 40–0 | 3–1 | Highmark Stadium | Recap |
| 5 | October 10 | at Kansas City Chiefs | W 38–20 | 4–1 | Arrowhead Stadium | Recap |
| 6 | October 18 | at Tennessee Titans | L 31–34 | 4–2 | Nissan Stadium | Recap |
| 7 | Bye | Bye | Bye | Bye | Bye | Bye |
| 8 | October 31 | Miami Dolphins | W 26–11 | 5–2 | Highmark Stadium | Recap |
| 9 | November 7 | at Jacksonville Jaguars | L 6–9 | 5–3 | TIAA Bank Field | Recap |
| 10 | November 14 | at New York Jets | W 45–17 | 6–3 | MetLife Stadium | Recap |
| 11 | November 21 | Indianapolis Colts | L 15–41 | 6–4 | Highmark Stadium | Recap |
| 12 | November 25 | at New Orleans Saints | W 31–6 | 7–4 | Caesars Superdome | Recap |
| 13 | December 6 | New England Patriots | L 10–14 | 7–5 | Highmark Stadium | Recap |
| 14 | December 12 | at Tampa Bay Buccaneers | L 27–33 (OT) | 7–6 | Raymond James Stadium | Recap |
| 15 | December 19 | Carolina Panthers | W 31–14 | 8–6 | Highmark Stadium | Recap |
| 16 | December 26 | at New England Patriots | W 33–21 | 9–6 | Gillette Stadium | Recap |
| 17 | January 2 | Atlanta Falcons | W 29–15 | 10–6 | Highmark Stadium | Recap |
| 18 | January 9 | New York Jets | W 27–10 | 11–6 | Highmark Stadium | Recap |
Note: Intra-division opponents are in bold text.

### Game summaries
#### Week 1: vs. Pittsburgh Steelers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Steelers | 0 | 0 | 6 | 17 | 23 |
| Bills | 3 | 7 | 0 | 6 | 16 |
at Highmark Stadium, Orchard Park, New York
* Date: September 12
* Game time: 1:00 p.m. EDT
* Game weather: Cloudy, 73 °F (23 °C)
* Game attendance: 69,787
* Referee: John Hussey
* TV announcers (CBS): Ian Eagle, Charles Davis, and Evan Washburn
* Recap, Game Book
Game information :
First quarter
BUF – Tyler Bass 37-yard field goal, 13:30. Bills 3–0. Drive: 4 plays, 5 yards, 1:30.
Second quarter
BUF – Gabe Davis 3-yard pass from Josh Allen (Tyler Bass kick), 0:22. Bills 10–0. Drive: 13 plays, 91 yards, 5:39.
Third quarter
PIT – Chris Boswell 24-yard field goal, 10:23. Bills 10–3. Drive: 10 plays, 69 yards, 4:37.
PIT – Chris Boswell 20-yard field goal, 1:47. Bills 10–6. Drive: 11 plays, 62 yards, 4:01.
Fourth quarter
PIT – Diontae Johnson 5-yard pass from Ben Roethlisberger (Chris Boswell kick), 11:19. Steelers 13–10. Drive: 4 plays, 52 yards, 2:23.
PIT – Ulysees Gilbert 9-yard return of blocked punt (Chris Boswell kick), 9:45. Steelers 20–10.
BUF – Tyler Bass 25-yard field goal, 5:23. Steelers 20–13. Drive: 9 plays, 67 yards, 4:22.
PIT – Chris Boswell 45-yard field goal, 2:42. Steelers 23–13. Drive: 9 plays, 48 yards, 2:41.
BUF – Tyler Bass 42-yard field goal, 0:46. Steelers 23–16. Drive: 10 plays, 40 yards, 1:56.
Top passers
PIT – Ben Roethlisberger – 18/32, 188 yards, TD
BUF – Josh Allen – 30/51, 270 yards, TD
Top rushers
PIT – Najee Harris – 16 rushes, 45 yards
BUF – Devin Singletary – 11 rushes, 72 yards
Top receivers
PIT – JuJu Smith-Schuster – 4 receptions, 52 yards
BUF – Stefon Diggs – 9 receptions, 69 yards :
Despite a 10–0 halftime lead and a strong performance from the Buffalo defense, the Bills' hopes for a third straight Week 1 victory were dashed after Pittsburgh scored 20 unanswered points in the second half, including a blocked punt returned for a touchdown. The Bills were also hurt by several penalties throughout the game. With the loss, Buffalo began the season 0–1 for the first time since 2018.

#### Week 2: at Miami Dolphins

| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 14 | 0 | 7 | 14 | 35 |
| Dolphins | 0 | 0 | 0 | 0 | 0 |
at Hard Rock Stadium, Miami Gardens, Florida
* Date: September 19
* Game time: 1:00 p.m. EDT
* Game weather: Mostly cloudy, 88 °F (31 °C)
* Game attendance: 65,040
* Referee: Craig Wrolstad
* TV announcers (Fox): Brandon Gaudin, Matt Millen, and Sarah Kustok
* Recap, Game Book
Game information :
First quarter
BUF – Devin Singletary 46-yard run (Tyler Bass kick), 12:33. Bills 7–0. Drive: 2 plays, 46 yards, 0:12.
BUF – Stefon Diggs 5-yard pass from Josh Allen (Tyler Bass kick), 7:02. Bills 14–0. Drive: 7 plays, 52 yards, 3:39.
Second quarter
No scoring plays
Third quarter
BUF – Dawson Knox 8-yard pass from Josh Allen (Tyler Bass kick), 11:48. Bills 21–0. Drive: 8 plays, 75 yards, 3:12.
Fourth quarter
BUF – Zack Moss 7-yard run (Tyler Bass kick), 13:38. Bills 28–0. Drive: 11 plays, 41 yards, 5:21.
BUF – Zack Moss 1-yard run (Tyler Bass kick), 7:45. Bills 35–0. Drive: 8 plays, 62 yards, 4:13.
Top passers
BUF – Josh Allen – 17/33, 179 yards, 2 TD, INT
MIA – Jacoby Brissett – 24/40, 169 yards, INT
Top rushers
BUF – Devin Singletary – 13 rushes, 82 yards, TD
MIA – Myles Gaskin – 5 rushes, 25 yards
Top receivers
BUF – Stefon Diggs – 4 receptions, 60 yards, TD
MIA – Jaylen Waddle – 6 receptions, 48 yards :
Buffalo rebounded from its loss the prior week with the most dominant win over division rival Miami in franchise history. Despite another mediocre performance by quarterback Josh Allen, a strong performance from running backs Devin Singletary and Zack Moss, as well as the defense, allowed the Bills to win 35–0. Dolphins quarterbacks Tua Tagovailoa and Jacoby Brissett were sacked six times, with Tagovailoa leaving the game in the first quarter after a rib injury.

#### Week 3: vs. Washington Football Team

| Quarter | 1 | 2 | 3 | 4 | Total |
| Washington | 0 | 14 | 0 | 7 | 21 |
| Bills | 7 | 20 | 9 | 7 | 43 |
at Highmark Stadium, Orchard Park, New York
* Date: September 26
* Game time: 1:00 p.m. EDT
* Game weather: Sunny, 66 °F (19 °C)
* Game attendance: 68,434
* Referee: Tony Corrente
* TV announcers (Fox): Chris Myers, Daryl Johnston, and Jen Hale
* Recap, Game Book
Game information :
First quarter
BUF – Emmanuel Sanders 28-yard pass from Josh Allen (Tyler Bass kick), 10:53. Bills 7–0. Drive: 8 plays, 75 yards, 4:07.
Second quarter
BUF – Zack Moss 7-yard pass from Josh Allen (Tyler Bass kick), 12:59. Bills 14–0. Drive: 8 plays, 52 yards, 4:12.
BUF – Dawson Knox 14-yard pass from Josh Allen (Tyler Bass kick), 10:42. Bills 21–0. Drive: 3 plays, 17 yards, 0:55.
WAS – Antonio Gibson 73-yard pass from Taylor Heinicke (Dustin Hopkins kick), 9:51. Bills 21–7. Drive: 2 plays, 75 yards, 0:51.
WAS – Taylor Heinicke 4-yard run (Dustin Hopkins kick), 7:39. Bills 21–14. Drive: 5 plays, 24 yards, 2:12.
BUF – Tyler Bass 21-yard field goal, 1:37. Bills 24–14. Drive: 7 plays, 55 yards, 1:52.
BUF – Tyler Bass 48-yard field goal, 0:00. Bills 27–14. Drive: 5 plays, 51 yards, 0:26.
Third quarter
BUF – Emmanuel Sanders 5-yard field pass from Josh Allen (pass failed), 4:43. Bills 33–14. Drive: 17 plays, 93 yards, 8:17.
BUF – Tyler Bass 29-yard field goal, 2:11. Bills 36–14. Drive: 4 plays, 6 yards, 0:53.
Fourth quarter
BUF – Josh Allen 2-yard run (Tyler Bass kick), 10:29. Bills 43–14. Drive: 3 plays, 22 yards, 1:08.
WAS – Logan Thomas 2-yard pass from Taylor Heinicke (Dustin Hopkins kick), 5:21. Bills 43–21. Drive: 10 plays, 75 yards, 5:08.
Top passers
WAS – Taylor Heinicke – 14/24, 212 yards, 2 TD, 2 INT
BUF – Josh Allen – 32/43, 358 yards, 4 TD
Top rushers
WAS – Antonio Gibson – 12 rushes, 31 yards
BUF – Zack Moss – 13 rushes, 60 yards
Top receivers
WAS – Antonio Gibson – 1 reception, 73 yards, TD
BUF – Cole Beasley – 11 receptions, 98 yards :
Josh Allen and the Bills' passing game enjoyed a strong performance, as Allen accounted for five total touchdowns and surpassed 300 passing yards for the first time in the season. Aside from a 73-yard scoring reception by running back Antonio Gibson and two scores from quarterback Taylor Heinicke set up by a Buffalo special teams gaffe and garbage time, respectively, Washington's offense struggled against the Bills defense. With another win, Buffalo improved to 2–1.

#### Week 4: vs. Houston Texans

| Quarter | 1 | 2 | 3 | 4 | Total |
| Texans | 0 | 0 | 0 | 0 | 0 |
| Bills | 7 | 9 | 3 | 21 | 40 |
at Highmark Stadium, Orchard Park, New York
* Date: October 3
* Game time: 1:00 p.m. EDT
* Game weather: Light rain, fog and mist, 67 °F (19 °C)
* Game attendance: 68,087
* Referee: Ronald Torbert
* TV announcers (CBS): Beth Mowins and Tiki Barber
* Recap, Game Book
Game information :
First quarter
BUF – Dawson Knox 25-yard pass from Josh Allen (Tyler Bass kick), 1:59. Bills 7–0. Drive: 9 plays, 69 yards, 5:02.
Second quarter
BUF – Tyler Bass 33-yard field goal, 13:05. Bills 10–0. Drive: 5 plays, 35 yards, 1:55.
BUF – Tyler Bass 26-yard field goal, 7:12. Bills 13–0. Drive: 7 plays, 41 yards, 3:31.
BUF – Tyler Bass 21-yard field goal, 0:23. Bills 16–0. Drive: 8 plays, 41 yards, 1:17.
Third quarter
BUF – Tyler Bass 28-yard field goal, 8:45. Bills 19–0. Drive: 11 plays, 65 yards, 6:15.
Fourth quarter
BUF – Dawson Knox 1-yard pass from Josh Allen (Tyler Bass kick), 13:29. Bills 26–0. Drive: 11 plays, 84 yards, 6:49.
BUF – Zack Moss 4-yard run (Tyler Bass kick), 10:44. Bills 33–0. Drive: 4 plays, 27 yards, 2:15.
BUF – Mitchell Trubisky 4-yard run (Tyler Bass kick), 3:36. Bills 40–0. Drive: 7 plays, 53 yards, 4:27.
Top passers
HOU – Davis Mills – 11/21, 87 yards, 4 INT
BUF – Josh Allen – 20/29, 248 yards, 2 TD, INT
Top rushers
HOU – Mark Ingram II – 6 rushes, 24 yards
BUF – Devin Singletary – 14 rushes, 79 yards
Top receivers
HOU – Brandin Cooks – 5 receptions, 47 yards
BUF – Stefon Diggs – 7 receptions, 114 yards :
Buffalo faced Houston for the first time since a 22–19 overtime loss in the 2019–20 NFL playoffs. Despite an early interception, Allen completed two touchdown passes to tight end Dawson Knox and led the Bills to 33 points before backup Mitchell Trubisky was substituted on in the fourth quarter. The Bills defense limited the Texans' rookie quarterback Davis Mills, filling in for former Bills starter Tyrod Taylor, to just 87 passing yards and intercepted him four times. The Texans finished with just 109 total offensive yards. With the 40–0 victory, their second shutout win of the season, the Bills improved to 3–1.

#### Week 5: at Kansas City Chiefs

| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 7 | 17 | 7 | 7 | 38 |
| Chiefs | 3 | 10 | 0 | 7 | 20 |
at Arrowhead Stadium, Kansas City, Missouri
* Date: October 10
* Game time: 8:20 p.m. EDT/7:20 p.m. CDT
* Game weather: 71 °F (22 °C)
* Game attendance: 73,389
* Referee: Carl Cheffers
* TV announcers (NBC): Al Michaels, Cris Collinsworth and Michele Tafoya
* Recap, Game Book
Game information :
First quarter
KC – Harrison Butker 38-yard field goal, 8:31. Chiefs 3–0. Drive: 17 plays, 56 yards, 6:29.
BUF – Josh Allen 9-yard run (Tyler Bass kick), 4:36. Bills 7–3. Drive: 8 plays, 75 yards, 3:55.
Second quarter
KC – Byron Pringle 5-yard pass from Patrick Mahomes (Harrison Butker kick), 10:00. Chiefs 10–7. Drive: 12 plays, 80 yards, 7:55.
BUF – Emmanuel Sanders 35-yard pass from Josh Allen (Tyler Bass kick), 7:45. Bills 14–10. Drive: 5 plays, 75 yards, 2:15.
BUF – Tyler Bass 30-yard field goal, 3:13. Bills 17–10. Drive: 7 plays, 62 yards, 2:33.
BUF – Dawson Knox 53-yard pass from Josh Allen (Tyler Bass kick), 1:16. Bills 24–10. Drive: 2 plays, 68 yards, 0:34.
KC – Harrison Butker 54-yard field goal, 0:02. Bills 24–13. Drive: 8 plays, 39 yards, 1:14.
Third quarter
BUF – Micah Hyde 26-yard interception return (Tyler Bass kick), 7:12. Bills 31–13.
Fourth quarter
KC – Travis Kelce 1-yard pass from Patrick Mahomes (Harrison Butker kick), 13:42. Bills 31–20. Drive: 7 plays, 52 yards, 2:32.
BUF – Emmanuel Sanders 8-yard pass from Josh Allen (Tyler Bass kick), 5:51. Bills 38–20. Drive: 12 plays, 85 yards, 7:51.
Top passers
BUF – Josh Allen – 15/26, 315 yards, 3 TD
KC – Patrick Mahomes – 33/54, 272 yards, 2 TD, 2 INT
Top rushers
BUF – Josh Allen – 11 rushes, 59 yards, TD
KC – Patrick Mahomes – 8 rushes, 61 yards
Top receivers
BUF – Dawson Knox – 3 receptions, 117 yards, TD
KC – Mecole Hardman – 9 receptions, 76 yards :
The Bills returned to Arrowhead Stadium for a Sunday night rematch of the previous season's AFC Championship game looking to avenge a 38–24 loss; in that same season, the Bills had also lost in the regular season to Kansas City. In a game nationally anticipated as a potential bellwether for AFC contention, the Bills scored 38 points, and they were dominant on both sides of the ball throughout the game. While Allen earned a 139.1 passer rating and threw for 315 yards (averaging 21 yards per pass completion), the Bills defense sacked Patrick Mahomes twice and forced him into three turnovers, with one being returned for a touchdown. The game was affected greatly by weather conditions, as a rain delay extended halftime by over an hour, and by numerous penalties, as the two teams combined for 158 penalty yards.
This was Buffalo's first win over Kansas City since 2017 and their first win with Mahomes as the Chiefs' starting quarterback. The win improved the Bills to 4–1.

#### Week 6: at Tennessee Titans

| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 3 | 17 | 11 | 0 | 31 |
| Titans | 0 | 17 | 7 | 10 | 34 |
at Nissan Stadium, Nashville, Tennessee
* Date: October 18
* Game time: 8:15 p.m. EDT/7:15 p.m. CDT
* Game weather: Clear, 65 °F (18 °C)
* Game attendance: 69,419
* Referee: Clete Blakeman
* TV announcers (ESPN): Steve Levy, Brian Griese, Louis Riddick and Lisa Salters
* Recap, Game Book
Game information :
First quarter
BUF – Tyler Bass 24-yard field goal, 6:07. Bills 3–0. Drive: 13 plays, 74 yards, 6:19.
Second quarter
BUF – Tyler Bass 28-yard field goal, 11:36. Bills 6–0. Drive: 10 plays, 38 yards, 4:27.
TEN – Derrick Henry 76-yard run (Randy Bullock kick), 11:20. Titans 7–6. Drive: 1 play, 76 yards, 0:16.
BUF – Stefon Diggs 14-yard pass from Josh Allen (Tyler Bass kick), 7:54. Bills 13–7. Drive: 7 plays, 72 yards, 3:26.
TEN – Randy Bullock 43-yard field goal, 5:04. Bills 13–10. Drive: 7 plays, 54 yards, 2:50.
TEN – Ryan Tannehill 4-yard run (Randy Bullock kick), 4:23. Titans 17–13. Drive: 2 plays, 11 yards, 0:31.
BUF – Cole Beasley 29-yard pass from Josh Allen (Tyler Bass kick), 0:40. Bills 20–17. Drive: 10 plays, 75 yards, 3:43.
Third quarter
BUF – Tyler Bass 52-yard field goal, 10:49. Bills 23–17. Drive: 9 plays, 48 yards, 4:11.
TEN – Derrick Henry 3-yard run (Randy Bullock kick), 4:23. Titans 24–23. Drive: 12 plays, 67 yards, 6:26.
BUF – Tommy Sweeney 1-yard pass from Josh Allen (Dawson Knox-Josh Allen pass), 0:27. Bills 31–24. Drive: 9 plays, 75 yards, 3:56.
Fourth quarter
TEN – Randy Bullock 38-yard field goal, 9:45. Bills 31–27. Drive: 9 plays, 45 yards, 5:42.
TEN – Derrick Henry 13-yard run (Randy Bullock kick), 3:05. Titans 34–31. Drive: 8 plays, 70 yards, 4:56.
Top passers
BUF – Josh Allen – 35/47, 353 yards, 3 TD, INT
TEN – Ryan Tannehill – 18/29, 216 yards, INT
Top rushers
BUF – Devin Singletary – 5 rushes, 27 yards
TEN – Derrick Henry – 20 rushes, 143 yards, 3 TD
Top receivers
BUF – Emmanuel Sanders – 5 receptions, 91 yards
TEN – A. J. Brown – 7 receptions, 91 yards :
The Bills attempted to avenge a 42–16 loss to the Titans from the previous season, which was rescheduled several times due to a COVID-19 outbreak in the Titans organization. In the final moments of a back-and-forth shootout on Monday Night Football, in which the lead changed seven times, the Titans defensive line stopped Josh Allen on a fourth-down quarterback sneak at the Tennessee 3-yard line, and Buffalo narrowly lost 34–31, falling to 4–2 ahead of its bye week.

#### Week 8: vs. Miami Dolphins

| Quarter | 1 | 2 | 3 | 4 | Total |
| Dolphins | 0 | 3 | 0 | 8 | 11 |
| Bills | 3 | 0 | 7 | 16 | 26 |
at Highmark Stadium, Orchard Park, New York
* Date: October 31
* Game time: 1:00 p.m. EDT
* Game weather: Cloudy, 51 °F (11 °C)
* Game attendance: 69,355
* Referee: Shawn Smith
* TV announcers (CBS): Andrew Catalon, James Lofton and Sherree Burruss
* Recap, Game Book
Game information :
First quarter
BUF – Tyler Bass 57-yard field goal, 3:48. Bills 3–0. Drive: 7 plays, 35 yards, 4:18.
Second quarter
MIA – Jason Sanders 51-yard field goal, 8:10. Tied 3–3. Drive: 7 plays, 32 yards, 3:51.
Third quarter
BUF – Gabe Davis 8-yard pass from Josh Allen (Tyler Bass kick), 3:49. Bills 10–3. Drive: 13 plays, 80 yards, 7:06.
Fourth quarter
BUF – Stefon Diggs 19-yard pass from Josh Allen (Tyler Bass kick), 13:23. Bills 17–3. Drive: 9 plays, 69 yards, 3:49.
MIA – Tua Tagovailoa 1-yard run (Tua Tagovailoa–Mike Gesicki pass), 9:39. Bills 17–11. Drive: 11 plays, 75 yards, 3:44.
BUF – Tyler Bass 39-yard field goal, 3:33. Bills 20–11. Drive: 14 plays, 59 yards, 6:10.
BUF – Josh Allen 7-yard run (run failed), 1:07. Bills 26–11. Drive: 3 plays, 11 yards, 1:14.
Top passers
MIA – Tua Tagovailoa – 21/39, 205 yards, INT
BUF – Josh Allen – 29/42, 249 yards, 2 TD
Top rushers
MIA – Myles Gaskin – 12 rushes, 36 yards
BUF – Josh Allen – 8 rushes, 55 yards, TD
Top receivers
MIA – DeVante Parker – 8 receptions, 85 yards
BUF – Cole Beasley – 10 receptions, 110 yards :
The Dolphins, who entered the game at 1–6, dominated the time of possession in the first half and limited Buffalo's offense to a field goal; however, they also squandered two scoring opportunities in the red zone, culminating in a 3–3 tie at halftime. The Bills would score two unanswered touchdowns to Gabe Davis and Stefon Diggs after halftime en route to a 26–11 win, their seventh straight over Miami.

#### Week 9: at Jacksonville Jaguars

| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 3 | 3 | 0 | 0 | 6 |
| Jaguars | 3 | 3 | 0 | 3 | 9 |
at TIAA Bank Field, Jacksonville, Florida
* Date: November 7
* Game time: 1:00 p.m. EST
* Game weather: Cloudy, 58 °F (14 °C)
* Game attendance: 63,110
* Referee: Land Clark
* TV announcers (CBS): Andrew Catalon, James Lofton and Jenny Dell
* Recap, Game Book
Game information :
First quarter
JAX – Matthew Wright 39-yard field goal, 8:57. Jaguars 3–0. Drive: 12 plays, 54 yards, 6:03.
BUF – Tyler Bass 24-yard field goal, 3:54. Tied 3–3. Drive: 12 plays, 48 yards, 5:03.
Second quarter
BUF – Tyler Bass 41-yard field goal, 10:59. Bills 6–3. Drive: 12 plays, 48 yards, 6:24.
JAX – Matthew Wright 55-yard field goal, 5:30. Tied 6–6. Drive: 10 plays, 38 yards, 5:29.
Third quarter
No scoring plays.
Fourth quarter
JAX – Matthew Wright 21-yard field goal, 12:10. Jaguars 9–6. Drive: 10 plays, 27 yards, 4:45.
Top passers
BUF – Josh Allen – 31/47, 264 yards, 2 INT
JAX – Trevor Lawrence – 15/26, 118 yards
Top rushers
BUF – Josh Allen – 5 rushes, 50 yards
JAX – Carlos Hyde – 21 rushes, 67 yards
Top receivers
BUF – Stefon Diggs – 6 receptions, 85 yards
JAX – Dan Arnold – 4 receptions, 60 yards :
The Bills entered this game as 14.5-point favorites over the 1–6 Jacksonville Jaguars. Nevertheless, the game was a defensive struggle, with neither team finding the end zone. Despite outgaining Jacksonville by 83 yards, the Bills lost the turnover battle 1–3, with all of their turnovers coming from quarterback Josh Allen (two interceptions and a lost fumble). Allen was sacked four times for 35 yards, and Buffalo was penalized 12 times for 118 yards. After allowing field goals on each of their first two drives, the Jaguars defense had their way with the Bills offensive line, which was missing Jon Feliciano and Spencer Brown due to injury. Notably, Josh Allen's namesake on the Jaguars sacked, intercepted, and recovered a fumble from his Bills counterpart. Jacksonville pulled off one of the biggest upsets in NFL history, defeating the Bills 9–6 and winning their first game in North America since Week 1 of the 2020 season. With the stunning loss, Buffalo fell to 5–3, with their division lead over the New England Patriots shrinking to just half a game.

#### Week 10: at New York Jets

| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 10 | 7 | 21 | 7 | 45 |
| Jets | 0 | 3 | 0 | 14 | 17 |
at MetLife Stadium, East Rutherford, New Jersey
* Date: November 14
* Game time: 1:00 p.m. EST
* Game weather: Overcast and brisk, 48 °F (9 °C)
* Game attendance: 77,625
* Referee: Scott Novak
* TV announcers (CBS): Spero Dedes and Jay Feely
* Recap, Game Book
Game information :
First quarter
BUF – Matt Breida 15-yard pass from Josh Allen (Tyler Bass kick), 12:15. Bills 7–0. Drive: 5 plays, 58 yards, 1:55.
BUF – Tyler Bass 29-yard field goal, 5:22. Bills 10–0. Drive: 9 plays, 33 yards, 3:55.
Second quarter
NYJ – Matt Ammendola 48-yard field goal, 1:53. Bills 10–3. Drive: 8 plays, 47 yards, 3:33.
BUF – Stefon Diggs 12-yard pass from Josh Allen (Tyler Bass kick), 0:53. Bills 17–3. Drive: 5 plays, 75 yards, 1:00.
Third quarter
BUF – Isaiah McKenzie 8-yard run (Tyler Bass kick), 12:01. Bills 24–3. Drive: 5 plays, 75 yards, 2:59.
BUF – Matt Breida 15-yard run (Tyler Bass kick), 10:47. Bills 31–3. Drive: 2 plays, 64 yards, 1:00.
BUF – Zack Moss 1-yard run (Tyler Bass kick), 6:01. Bills 38–3. Drive: 4 plays, 45 yards, 2:18.
Fourth quarter
NYJ – Michael Carter 1-yard run (Matt Ammendola kick), 11:58. Bills 38–10. Drive: 11 plays, 35 yards, 3:34.
BUF – Devin Singletary 2-yard run (Tyler Bass kick), 5:52. Bills 45–10. Drive: 4 plays, 57 yards, 2:18.
NYJ – Elijah Moore 15-yard pass from Joe Flacco (Matt Ammendola kick), 2:08. Bills 45–17. Drive: 8 plays, 68 yards, 3:44.
Top passers
BUF – Josh Allen – 21/28, 366 yards, 2 TD, INT
NYJ – Mike White – 24/44, 251 yards, 4 INT
Top rushers
BUF – Devin Singletary – 7 rushes, 43 yards, TD
NYJ – Michael Carter – 16 rushes, 39 yards, TD
Top receivers
BUF – Stefon Diggs – 8 receptions, 162 yards, TD
NYJ – Corey Davis – 5 receptions, 93 yards :
Buffalo rebounded against the divisional rival New York Jets, scoring six touchdowns after being held out of the endzone the week prior, with two of those touchdowns accounted for by third string running back Matt Breida. On defense, all five starting defensive backs for the Bills, namely Taron Johnson, Micah Hyde, Tre'Davious White, Levi Wallace, and Jordan Poyer, recorded a turnover off the Jets' offense, stifling quarterback Mike White. With the 45–17 win, Buffalo improved to 6–3.

#### Week 11: vs. Indianapolis Colts

| Quarter | 1 | 2 | 3 | 4 | Total |
| Colts | 14 | 10 | 14 | 3 | 41 |
| Bills | 0 | 7 | 0 | 8 | 15 |
at Highmark Stadium, Orchard Park, New York
* Date: November 21
* Game time: 1:00 p.m. EST
* Game weather: Cloudy, 49 °F (9 °C)
* Game attendance: 69,866
* Referee: Brad Rogers
* TV announcers (CBS): Kevin Harlan, Trent Green, and Melanie Collins
* Recap, GameBook
Game information :
First quarter
IND – Jonathan Taylor 3-yard run (Michael Badgley kick), 8:55. Colts 7–0. Drive: 11 plays, 65 yards, 6:05.
IND – Jonathan Taylor 23-yard pass from Carson Wentz (Michael Badgley kick), 1:38. Colts 14–0. Drive: 5 plays, 57 yards, 2:20.
Second quarter
BUF – Stefon Diggs 6-yard pass from Josh Allen (Tyler Bass kick), 10:44. Colts 14–7. Drive: 11 plays, 73 yards, 5:54.
IND – Michael Badgley 36-yard field goal, 2:12. Colts 17–7. Drive: 15 plays, 58 yards, 8:32.
IND – Jonathan Taylor 2-yard run (Michael Badgley kick), 1:59. Colts 24–7. Drive: 1 play, 2 yards, 0:04.
Third quarter
IND – Jonathan Taylor 10-yard run (Michael Badgley kick), 5:27. Colts 31–7. Drive: 5 plays, 61 yards, 2:46.
IND – Jonathan Taylor 1-yard run (Michael Badgley kick), 0:58. Colts 38–7. Drive: 6 plays, 24 yards, 3:31.
Fourth quarter
BUF – Stefon Diggs 9-yard pass from Josh Allen (Josh Allen run), 12:42. Colts 38–15. Drive: 10 plays, 77 yards, 3:16.
IND – Michael Badgley 35-yard field goal, 6:23. Colts 41–15. Drive: 10 plays, 63 yards, 6:19.
Top passers
IND – Carson Wentz – 11/20, 106 yards, TD
BUF – Josh Allen – 21/35, 209 yards, 2 TD, 2 INT
Top rushers
IND – Jonathan Taylor – 32 rushes, 185 yards, 4 TD
BUF – Matt Breida – 5 rushes, 51 yards
Top receivers
IND – Jack Doyle – 3 receptions, 30 yards
BUF – Dawson Knox – 6 receptions, 80 yards :
The Bills defense, missing key run-stoppers Star Lotulelei and Tremaine Edmunds, struggled to contain Colts RB Jonathan Taylor, who scored five total touchdowns from scrimmage. To make matters worse, the Buffalo offense and special teams unit committed key turnovers, contributing to a 41–15 blowout loss. Buffalo fell to 6–4, also falling to second place in the AFC East as the Patriots had won earlier that week. This was the first NFL game to ever end in the score of 15–41, a scorigami.

#### Week 12: at New Orleans Saints

Thanksgiving Day games
| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 7 | 3 | 14 | 7 | 31 |
| Saints | 0 | 0 | 0 | 6 | 6 |
at Caesars Superdome, New Orleans, Louisiana
* Date: November 25
* Game time: 8:20 p.m. EST/7:20 p.m. CST
* Game weather: None (indoor stadium)
* Game attendance: 69,170
* Referee: Brad Allen
* TV announcers (NBC): Mike Tirico, Drew Brees and Michele Tafoya
* Recap, Game Book
Game information :
First quarter
BUF – Dawson Knox 7-yard pass from Josh Allen (Tyler Bass kick), 7:09. Bills 7–0. Drive: 10 plays, 65 yards, 5:54.
Second quarter
BUF – Tyler Bass 34-yard field goal, 8:46. Bills 10–0. Drive: 7 plays, 38 yards, 4:00.
Third quarter
BUF – Stefon Diggs 5-yard pass from Josh Allen (Tyler Bass kick), 8:48. Bills 17–0. Drive: 11 plays, 75 yards, 6:12.
BUF – Dawson Knox 24-yard pass from Josh Allen (Tyler Bass kick), 4:19. Bills 24–0. Drive: 5 plays, 53 yards, 2:51.
Fourth quarter
NO – Nick Vannett 11-yard pass from Trevor Siemian (pass failed), 14:54. Bills 24–6. Drive: 10 plays, 75 yards, 4:25.
BUF – Matt Breida 23-yard pass from Josh Allen (Tyler Bass kick), 8:17. Bills 31–6. Drive: 4 plays, 51 yards, 2:25.
Top passers
BUF – Josh Allen – 23/28, 260 yards, 4 TD, 2 INT
NO – Trevor Siemian – 17/29, 163 yards, TD, INT
Top rushers
BUF – Devin Singletary – 15 rushes, 44 yards
NO – Tony Jones Jr. – 16 rushes, 27 yards
Top receivers
BUF – Stefon Diggs – 7 receptions, 74 yards, TD
NO – Lil'Jordan Humphrey – 3 receptions, 47 yards :
In their second Thanksgiving Day game in three years, the Bills traveled south to play the injury-depleted Saints. Josh Allen continued to struggle with interceptions, throwing two in the second quarter, but also threw four touchdown passes, including two to Dawson Knox, as Buffalo routed New Orleans 31–6 to improve to 7–4. They also lost Tre'Davious White for the season to a torn ACL suffered during the game.

#### Week 13: vs. New England Patriots

| Quarter | 1 | 2 | 3 | 4 | Total |
| Patriots | 8 | 3 | 0 | 3 | 14 |
| Bills | 7 | 0 | 3 | 0 | 10 |
at Highmark Stadium, Orchard Park, New York
* Date: December 6
* Game time: 8:15 p.m. EST
* Game weather: Cloudy, Windy, 36 °F (2 °C)
* Game attendance: 69,694
* Referee: Bill Vinovich
* TV announcers (ESPN): Steve Levy, Brian Griese, Louis Riddick and Lisa Salters
* Recap, Game Book
Game information :
First quarter
NE – Damien Harris 64-yard run (Brandon Bolden run), 5:18. Patriots 8–0. Drive: 3 plays, 69 yards, 1:37.
BUF – Gabe Davis 14-yard pass from Josh Allen (Tyler Bass kick), 2:02. Patriots 8–7. Drive: 1 play, 14 yards, 0:05.
Second quarter
NE – Nick Folk 41-yard field goal, 11:28. Patriots 11–7. Drive: 9 plays, 52 yards, 5:34.
Third quarter
BUF – Tyler Bass 35-yard field goal, 6:35. Patriots 11–10. Drive: 8 plays, 46 yards, 2:40.
Fourth quarter
NE – Nick Folk 34-yard field goal, 13:01. Patriots 14–10. Drive: 14 plays, 59 yards, 8:34.
Top passers
NE – Mac Jones – 2/3, 19 yards
BUF – Josh Allen – 15/30, 145 yards, TD
Top rushers
NE – Damien Harris – 10 rushes, 111 yards, TD
BUF – Josh Allen – 6 rushes, 39 yards
Top receivers
NE – Jonnu Smith – 1 reception, 12 yards
BUF – Stefon Diggs – 4 receptions, 51 yards :
In a game affected by winds greater than 40 miles per hour, divisional rival New England ran the ball 46 times and only threw three passes, accumulating over 200 rushing yards and just 19 passing yards. The Bills also tried a run-heavy approach but relied more on the passing game late in the game despite the heavy winds affecting several of Josh Allen's passes. New England never trailed after taking the early lead with a 64-yard rushing touchdown by Damien Harris, and Buffalo finished just 1 for 4 on redzone possessions, leading to a 14–10 loss to the Patriots.

#### Week 14: at Tampa Bay Buccaneers

| Quarter | 1 | 2 | 3 | 4 | OT | Total |
| Bills | 0 | 3 | 7 | 17 | 0 | 27 |
| Buccaneers | 7 | 17 | 0 | 3 | 6 | 33 |
at Raymond James Stadium, Tampa, Florida
* Date: December 12
* Game time: 4:25 p.m. EST
* Game weather: Cloudy, 81 °F (27 °C)
* Game attendance: 65,655
* Referee: Scott Novak
* TV announcers (CBS): Jim Nantz, Tony Romo and Tracy Wolfson
* Recap, Game Book
Game information :
First quarter
TB – Leonard Fournette 47-yard run (Ryan Succop kick), 8:13. Buccaneers 7–0. Drive: 5 plays, 67 yards, 1:42.
Second quarter
TB – Ryan Succop 23-yard field goal, 13:36. Buccaneers 10–0. Drive: 15 plays, 80 yards, 6:43.
BUF – Tyler Bass 21-yard field goal, 9:28. Buccaneers 10–3. Drive: 7 plays, 72 yards, 4:08.
TB – Mike Evans 13-yard pass from Tom Brady (Ryan Succop kick), 7:11. Buccaneers 17–3. Drive: 7 plays, 75 yards, 2:17.
TB – Tom Brady 1-yard run (Ryan Succop kick), 1:29. Buccaneers 24–3. Drive: 10 plays, 72 yards, 2:43.
Third quarter
BUF – Josh Allen 18-yard run (Tyler Bass kick), 7:29. Buccaneers 24–10. Drive: 9 plays, 81 yards, 3:40.
Fourth quarter
TB – Ryan Succop 24-yard field goal, 11:20. Buccaneers 27–10. Drive: 11 plays, 84 yards, 5:51.
BUF – Dawson Knox 15-yard pass from Josh Allen (Tyler Bass kick), 9:07. Buccaneers 27–17. Drive: 5 plays, 75 yards, 2:13.
BUF – Gabe Davis 4-yard pass from Josh Allen (Tyler Bass kick), 4:53. Buccaneers 27–24. Drive: 9 plays, 46 yards, 3:15.
BUF – Tyler Bass 25-yard field goal, 0:22. Tied 27–27. Drive: 14 plays, 70 yards, 2:43.
Overtime
TB – Breshad Perriman 58-yard pass from Tom Brady, 5:31. Buccaneers 33–27. Drive: 6 plays, 94 yards, 3:17
Top passers
BUF – Josh Allen – 36/54, 308 yards, 2 TD, INT
TB – Tom Brady – 31/46, 363 yards, 2 TD
Top rushers
BUF – Josh Allen – 12 rushes, 109 yards, TD
TB – Leonard Fournette – 19 rushes, 113 yards, TD
Top receivers
BUF – Stefon Diggs – 7 receptions, 74 yards
TB – Chris Godwin – 10 receptions, 105 yards :
The Buccaneers raced to a 24–3 halftime lead under former Patriots quarterback Tom Brady, along with a strong first-half performance by running back Leonard Fournette and a furious pass rush that largely shut down Josh Allen and the Bills' offense, which did not hand off the ball to a running back in the first half, the first time an NFL team had not done so since 1991. However, the Bills mounted a comeback, outscoring Tampa Bay 24–3 in the second half, to force overtime. After a three and out on the first series of the extra period, a 63-yard punt from Matt Haack pushed Tampa Bay to its own 6-yard line. A controversial pass interference call on Levi Wallace allowed Tampa Bay to convert a 3rd-and-long, and the Buccaneers sealed the game minutes later with a 58-yard catch-and-run touchdown pass from Brady to Breshad Perriman, sending Buffalo to a 7–6 record with the loss. Allen became just the fourth quarterback in NFL history with 300 passing yards and 100 rushing yards in the same game, playing through a sprained ankle suffered in the fourth quarter.

#### Week 15: vs. Carolina Panthers

| Quarter | 1 | 2 | 3 | 4 | Total |
| Panthers | 0 | 8 | 0 | 6 | 14 |
| Bills | 0 | 17 | 7 | 7 | 31 |
at Highmark Stadium, Orchard Park, New York
* Date: December 19
* Game time: 1:00 p.m. EST
* Game weather: Cloudy, 29 °F (−2 °C)
* Game attendance: 65,398
* Referee: Clete Blakeman
* TV announcers (Fox): Kenny Albert, Jonathan Vilma, and Lindsay Czarniak
* Recap, Game Book
Game information :
First quarter
No scoring plays
Second quarter
BUF – Devin Singletary 16-yard run (Tyler Bass kick), 14:13. Bills 7–0. Drive: 6 plays, 50 yards, 2:48.
BUF – Stefon Diggs 11-yard pass from Josh Allen (Tyler Bass kick), 9:41. Bills 14–0. Drive: 5 plays, 57 yards, 2:36.
CAR – Cam Newton 4-yard run (Cam Newton–D. J. Moore pass), 1:48. Bills 14–8. Drive: 3 plays, 37 yards, 0:57.
BUF – Tyler Bass 26-yard field goal, 0:00. Bills 17–8. Drive: 11 plays, 63 yards, 1:48.
Third quarter
BUF – Gabe Davis 20-yard pass from Josh Allen (Tyler Bass kick), 5:52. Bills 24–8. Drive: 10 plays, 74 yards, 3:42.
Fourth quarter
CAR – Ameer Abdullah 23-yard pass from Cam Newton (run failed), 11:01. Bills 24–14. Drive: 4 plays, 43 yards, 1:22.
BUF – Gabe Davis 14-yard pass from Josh Allen (Tyler Bass kick), 2:07. Bills 31–14. Drive: 9 plays, 46 yards, 4:04.
Top passers
CAR – Cam Newton – 18/38, 156 yards, TD, INT
BUF – Josh Allen – 19/34, 210 yards, 3 TD, INT
Top rushers
CAR – Cam Newton – 15 rushes, 71 yards, TD
BUF – Devin Singletary – 22 rushes, 86 yards, TD
Top receivers
CAR – D. J. Moore – 6 receptions, 48 yards
BUF – Gabe Davis – 5 receptions, 85 yards, 2 TD :
With the win, Buffalo snapped a two-game losing streak and improved to 8–6.

#### Week 16: at New England Patriots

| Quarter | 1 | 2 | 3 | 4 | Total |
| Bills | 7 | 10 | 3 | 13 | 33 |
| Patriots | 0 | 7 | 7 | 7 | 21 |
at Gillette Stadium, Foxborough, Massachusetts
* Date: December 26
* Game time: 1:00 p.m. EST
* Game weather: Cloudy, 37 °F (3 °C)
* Game attendance: 65,878
* Referee: Shawn Smith
* TV announcers (CBS): Ian Eagle, Charles Davis, and Evan Washburn
* Recap, Game Book
Game information :
First quarter
BUF – Isaiah McKenzie 3-yard pass from Josh Allen (Tyler Bass kick), 6:37. Bills 7–0. Drive: 13 plays, 61 yards, 6:57.
Second quarter
NE – Damien Harris 16-yard run (Nick Folk kick), 14:28. Tied 7–7. Drive: 13 plays, 75 yards, 7:09.
BUF – Tyler Bass 25-yard field goal, 9:01. Bills 10–7. Drive: 10 plays, 68 yards, 5:27.
BUF – Stefon Diggs 12-yard pass from Josh Allen (Tyler Bass kick), 1:45. Bills 17–7. Drive: 7 plays, 42 yards, 1:25.
Third quarter
BUF – Tyler Bass 34-yard field goal, 9:02. Bills 20–7. Drive: 14 plays, 64 yards, 5:58.
NE – Damien Harris 1-yard run (Nick Folk kick), 1:41. Bills 20–14. Drive: 14 plays, 75 yards, 7:21.
Fourth quarter
BUF – Devin Singletary 2-yard run (pass failed), 11:42. Bills 26–14. Drive: 9 plays, 66 yards, 4:59.
NE – Damien Harris 8-yard run (Nick Folk kick), 7:37. Bills 26–21. Drive: 10 plays, 75 yards, 4:05.
BUF – Dawson Knox 2-yard pass from Josh Allen (Tyler Bass kick), 2:30. Bills 33–21. Drive: 13 plays, 75 yards, 5:07.
Top passers
NE – Mac Jones – 14/32, 145 yards, 2 INT
BUF – Josh Allen – 30/47, 314 yards, 3 TD
Top rushers
NE – Damien Harris – 18 rushes, 103 yards, 3 TD
BUF – Josh Allen – 12 rushes, 64 yards
Top receivers
NE – Jakobi Meyers – 6 receptions, 59 yards
BUF – Isaiah McKenzie – 11 receptions, 125 yards, TD :
Buffalo avenged its Monday Night loss to the Patriots earlier in December, as Josh Allen passed for over 300 yards and 3 touchdowns and was not sacked during the game. Despite receivers Cole Beasley and Gabe Davis coming down with COVID-19 and missing the game, utility player Isaiah McKenzie had a dominant performance in Beasley's place. New England relied heavily on its run game again, with Damien Harris scoring 3 touchdowns, but was forced to pass more with rookie quarterback Mac Jones, who completed less than 50 percent of his throws and was intercepted twice by Micah Hyde. With the 33–21 win, Buffalo improved to 9–6 and retook the division lead from New England.

#### Week 17: vs. Atlanta Falcons

| Quarter | 1 | 2 | 3 | 4 | Total |
| Falcons | 2 | 13 | 0 | 0 | 15 |
| Bills | 14 | 0 | 8 | 7 | 29 |
at Highmark Stadium, Orchard Park, New York
* Date: January 2
* Game time: 1:00 p.m. EST
* Game weather: Snow showers, 25 °F (−4 °C)
* Game attendance: 64,948
* Referee: Land Clark
* TV announcers (Fox): Kevin Kugler, Mark Sanchez and Laura Okmin
* Recap, Game Book
Game information :
First quarter
ATL – Jake Kumerow tackled in end zone for a safety, 11:04. Falcons 2–0.
BUF – Josh Allen 1-yard run (Tyler Bass kick), 3:15. Bills 7–2. Drive: 15 plays, 69 yards, 6:10.
BUF – Josh Allen 4-yard run (Tyler Bass kick), 0:35. Bills 14–2. Drive: 6 plays, 18 yards, 1:52.
Second quarter
ATL – Younghoe Koo 28-yard field goal, 10:08. Bills 14–5. Drive: 10 plays, 65 yards, 5:27.
ATL – Mike Davis 1-yard run (Younghoe Koo kick), 1:48. Bills 14–12. Drive: 5 plays, 80 yards, 1:32.
ATL – Younghoe Koo 24-yard field goal, 0:00. Falcons 15–14. Drive: 7 plays, 50 yards, 1:06.
Third quarter
BUF – Devin Singletary 6-yard run (Josh Allen–Cole Beasley pass), 5:56. Bills 22–15. Drive: 11 plays, 80 yards, 6:36.
Fourth quarter
BUF – Devin Singletary 4-yard run (Tyler Bass kick), 10:46. Bills 29–15. Drive: 12 plays, 65 yards, 7:18.
Top passers
ATL – Matt Ryan – 13/23, 197 yards
BUF – Josh Allen – 11/26, 120 yards, 3 INT
Top rushers
ATL – Mike Davis – 8 rushes, 42 yards, TD
BUF – Devin Singletary – 23 rushes, 110 yards, 2 TD
Top receivers
ATL – Kyle Pitts – 2 receptions, 69 yards
BUF – Stefon Diggs – 5 receptions, 52 yards :
Despite Allen turning in one of the worst passing performances of his career, he and running back Devin Singletary combined for four rushing touchdowns as Buffalo overcame 3 turnovers and a Falcons lead at halftime to win 29–15, clinching a playoff berth for the fourth time in five years.

#### Week 18: vs. New York Jets

| Quarter | 1 | 2 | 3 | 4 | Total |
| Jets | 0 | 7 | 3 | 0 | 10 |
| Bills | 10 | 3 | 0 | 14 | 27 |
at Highmark Stadium, Orchard Park, New York
* Date: January 9
* Game time: 4:25 p.m. EST
* Game weather: Snow showers, 34 °F (1 °C)
* Game attendance: 64,783
* Referee: John Hussey
* TV announcers (CBS): Kevin Harlan, Trent Green, and Melanie Collins
* Recap, Game Book
Game information :
First quarter
BUF – Stefon Diggs 10-yard pass from Josh Allen (Tyler Bass kick), 10:42. Bills 7–0. Drive: 7 plays, 75 yards, 4:18.
BUF – Tyler Bass 41-yard field goal, 2:31. Bills 10–0. Drive: 13 plays, 70 yards, 6:29.
Second quarter
NYJ – Keelan Cole 40-yard pass from Zach Wilson (Eddy Piñeiro kick), 3:51. Bills 10–7. Drive: 4 plays, 45 yards, 1:31.
BUF – Tyler Bass 21-yard field goal, 0:00. Bills 13–7. Drive: 10 plays, 81 yards, 1:39.
Third quarter
NYJ – Eddy Piñeiro 49-yard field goal, 3:55. Bills 13–10. Drive: 4 plays, −9 yards, 1:31.
Fourth quarter
BUF – Devin Singletary 1-yard run (Tyler Bass kick), 8:21. Bills 20–10. Drive: 7 plays, 51 yards, 4:12.
BUF – Devin Singletary 5-yard pass from Josh Allen (Tyler Bass kick), 3:53. Bills 27–10. Drive: 7 plays, 48 yards, 3:31.
Top passers
NYJ – Zach Wilson – 7/20, 87 yards, TD
BUF – Josh Allen – 24/45, 239 yards, 2 TD
Top rushers
NYJ – Zach Wilson – 2 rushes, 24 yards
BUF – Devin Singletary – 19 rushes, 88 yards, TD
Top receivers
NYJ – Keelan Cole – 3 receptions, 54 yards, TD
BUF – Stefon Diggs – 9 receptions, 81 yards, TD :
The Bills held the lead the whole way during the game, holding the Jets offense to just 53 total yards on offense and recording nine quarterback sacks en route to a 27–10 win, which assured them the division title. Had they lost, they would have needed the Patriots to lose to Miami to clinch the division. A New England loss, combined with a subsequent victory by the Las Vegas Raiders late that night, sealed the 3rd seed for the Bills, and the Patriots as their opponent for the Wild Card game.

### Standings
#### Division

AFC East :
| viewtalkedit | W | L | T | PCT | DIV | CONF | PF | PA | STK |
| $^{(3)}$ Buffalo Bills | 11 | 6 | 0 | .647 | 5–1 | 7–5 | 483 | 289 | W4 |
| $^{(6)}$ New England Patriots | 10 | 7 | 0 | .588 | 3–3 | 8–4 | 462 | 303 | L1 |
| Miami Dolphins | 9 | 8 | 0 | .529 | 4–2 | 6–6 | 341 | 373 | W1 |
| New York Jets | 4 | 13 | 0 | .235 | 0–6 | 4–8 | 310 | 504 | L2 |

#### Conference

AFCvte :
| # | Team | Division | W | L | T | PCT | DIV | CONF | SOS | SOV | STK |
| Division winners ||||||||||||
| 1 | Tennessee Titans | South | 12 | 5 | 0 | .706 | 5–1 | 8–4 | .472 | .480 | W3 |
| 2 | Kansas City Chiefs | West | 12 | 5 | 0 | .706 | 5–1 | 7–5 | .538 | .517 | W1 |
| 3 | Buffalo Bills | East | 11 | 6 | 0 | .647 | 5–1 | 7–5 | .472 | .428 | W4 |
| 4 | Cincinnati Bengals | North | 10 | 7 | 0 | .588 | 4–2 | 8–4 | .472 | .462 | L1 |
| Wild cards ||||||||||||
| 5 | Las Vegas Raiders | West | 10 | 7 | 0 | .588 | 3–3 | 8–4 | .510 | .515 | W4 |
| 6 | New England Patriots | East | 10 | 7 | 0 | .588 | 3–3 | 8–4 | .481 | .394 | L1 |
| 7 | Pittsburgh Steelers | North | 9 | 7 | 1 | .559 | 4–2 | 7–5 | .521 | .490 | W2 |
| Did not qualify for the postseason ||||||||||||
| 8 | Indianapolis Colts | South | 9 | 8 | 0 | .529 | 3–3 | 7–5 | .495 | .431 | L2 |
| 9 | Miami Dolphins | East | 9 | 8 | 0 | .529 | 4–2 | 6–6 | .464 | .379 | W1 |
| 10 | Los Angeles Chargers | West | 9 | 8 | 0 | .529 | 3–3 | 6–6 | .510 | .500 | L1 |
| 11 | Cleveland Browns | North | 8 | 9 | 0 | .471 | 3–3 | 5–7 | .514 | .415 | W1 |
| 12 | Baltimore Ravens | North | 8 | 9 | 0 | .471 | 1–5 | 5–7 | .531 | .460 | L6 |
| 13 | Denver Broncos | West | 7 | 10 | 0 | .412 | 1–5 | 3–9 | .484 | .357 | L4 |
| 14 | New York Jets | East | 4 | 13 | 0 | .235 | 0–6 | 4–8 | .512 | .426 | L2 |
| 15 | Houston Texans | South | 4 | 13 | 0 | .235 | 3–3 | 4–8 | .498 | .397 | L2 |
| 16 | Jacksonville Jaguars | South | 3 | 14 | 0 | .176 | 1–5 | 3–9 | .512 | .569 | W1 |
| Tiebreakers ||||||||||||
| 1 2 Tennessee finished ahead of Kansas City based on head-to-head victory, claiming the No. 1 seed. 1 2 Las Vegas claimed the No. 5 seed over New England based on win percentage in common games (5–1 vs. 2–4 against: Miami, Dallas, LA Chargers, Cleveland, and Indianapolis). 1 2 3 Indianapolis finished ahead of Miami and Los Angeles based on conference record (7–5 vs. 6–6). 1 2 Miami finished ahead of LA Chargers based on win percentage in common games (5–1 vs. 2–4 against: New England, Las Vegas, Houston, Baltimore, and NY Giants). 1 2 Cleveland finished ahead of Baltimore based on division record (3–3 vs. 1–5). 1 2 NY Jets finished ahead of Houston based on head-to-head victory. ↑ When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest-ranked remaining team from each division. ||||||||||||

## Postseason
### Schedule

| Round | Date | Opponent (seed) | Result | Record | Venue | Recap |
| Wild Card | January 15 | New England Patriots (6) | W 47–17 | 1–0 | Highmark Stadium | Recap |
| Divisional | January 23 | at Kansas City Chiefs (2) | L 36–42 (OT) | 1–1 | Arrowhead Stadium | Recap |

### Game summaries
#### AFC Wild Card Playoffs: vs. (6) New England Patriots

| Quarter | 1 | 2 | 3 | 4 | Total |
| Patriots | 0 | 3 | 7 | 7 | 17 |
| Bills | 14 | 13 | 6 | 14 | 47 |
at Highmark Stadium, Orchard Park, New York
* Date: January 15, 2022
* Game time: 8:15 p.m. EST
* Game weather: Clear, 7 °F (−14 °C)
* Game attendance: 69,188
* Referee: Brad Allen
* TV announcers (CBS): Ian Eagle, Charles Davis, and Evan Washburn
* Recap, Game Book
Game information :
First quarter
BUF – Dawson Knox 8-yard pass from Josh Allen (Tyler Bass kick), 9:45. Bills 7–0. Drive: 9 plays, 70 yards, 5:15.
BUF – Dawson Knox 11-yard pass from Josh Allen (Tyler Bass kick), 0:40. Bills 14–0. Drive: 10 plays, 80 yards, 5:00.
Second quarter
BUF – Devin Singletary 3-yard run (kick blocked), 7:20. Bills 20–0. Drive: 10 plays, 81 yards, 6:03.
BUF – Devin Singletary 16-yard run (Tyler Bass kick), 1:53 . Bills 27–0. Drive: 4 plays, 89 yards, 1:51.
NE – Nick Folk 44-yard field goal, 0:01. Bills 27–3. Drive: 10 plays, 49 yards, 1:52.
Third quarter
BUF – Emmanuel Sanders 34-yard pass from Josh Allen (kick blocked), 8:48. Bills 33–3. Drive: 6 plays, 58 yards, 4:05.
NE – Kendrick Bourne 3-yard pass from Mac Jones (Nick Folk kick), 4:12. Bills 33–10. Drive: 11 plays, 75 yards, 4:36.
Fourth quarter
BUF – Gabe Davis 19-yard pass from Josh Allen (Tyler Bass kick), 13:22. Bills 40–10. Drive: 9 plays, 77 yards, 5:50.
BUF – Tommy Doyle 1-yard pass from Josh Allen (Tyler Bass kick), 8:37. Bills 47–10. Drive: 3 plays, 39 yards, 1:36.
NE – Kendrick Bourne 4-yard pass from Mac Jones (Nick Folk kick), 1:44. Bills 47–17. Drive: 15 plays, 75 yards, 6:53.
Top passers
NE – Mac Jones – 24/38, 232 yards, 2 TD, 2 INT
BUF – Josh Allen – 21/25, 308 yards, 5 TD
Top rushers
NE – Damien Harris – 9 rushes, 30 yards
BUF – Devin Singletary – 16 rushes, 81 yards, 2 TD
Top receivers
NE – Kendrick Bourne – 7 receptions, 77 yards, 2 TD
BUF – Dawson Knox – 5 receptions, 89 yards, 2 TD :
The Bills became the first team in the Super Bowl era to score a touchdown on each of their first seven drives of a playoff game. Additionally, they became the only team in NFL history to not attempt a field goal, punt, or commit a turnover in a single game (regular season or postseason).

#### AFC Divisional Playoffs: at (2) Kansas City Chiefs

| Quarter | 1 | 2 | 3 | 4 | OT | Total |
| Bills | 7 | 7 | 7 | 15 | 0 | 36 |
| Chiefs | 7 | 7 | 9 | 13 | 6 | 42 |
at Arrowhead Stadium, Kansas City, Missouri
* Date: January 23, 2022
* Game time: 6:30 p.m. EST/5:30 p.m. CST
* Game weather: 37 °F (3 °C)
* Game attendance: 73,242
* Referee: John Hussey
* TV announcers (CBS): Jim Nantz, Tony Romo, Tracy Wolfson, and Jay Feely
* Recap, Game Book
Game information :
First quarter
BUF – Devin Singletary 1-yard run (Tyler Bass kick), 8:03. Bills 7–0. Drive: 13 plays, 71 yards, 6:57.
KC – Patrick Mahomes 8-yard run (Harrison Butker kick), 2:26. Tied 7–7. Drive: 11 plays, 74 yards, 5:37.
Second quarter
KC – Byron Pringle 2-yard pass from Patrick Mahomes (Harrison Butker kick), 1:52. Chiefs 14–7. Drive: 12 plays, 86 yards, 6:51.
BUF – Gabe Davis 18-yard pass from Josh Allen (Tyler Bass kick), 0:37. Tied 14–14. Drive: 7 plays, 75 yards, 1:15.
Third quarter
KC – Harrison Butker 39-yard field goal, 7:01. Chiefs 17–14. Drive: 13 plays, 54 yards, 7:59.
KC – Mecole Hardman 25-yard run (kick failed, hit left upright), 2:06. Chiefs 23–14. Drive: 5 plays, 61 yards, 2:43.
BUF – Gabe Davis 75-yard pass from Josh Allen (Tyler Bass kick), 1:56. Chiefs 23–21. Drive: 1 play, 75 yards, 0:10.
Fourth quarter
KC – Harrison Butker 28-yard field goal, 8:55. Chiefs 26–21. Drive: 4 plays, 6 yards, 2:33.
BUF – Gabe Davis 27-yard pass from Josh Allen (Josh Allen–Stefon Diggs pass), 1:54. Bills 29–26. Drive: 17 plays, 75 yards, 7:01.
KC – Tyreek Hill 64-yard pass from Patrick Mahomes (Harrison Butker kick), 1:02. Chiefs 33–29. Drive: 5 plays, 75 yards, 0:52.
BUF – Gabe Davis 19-yard pass from Josh Allen (Tyler Bass kick), 0:13. Bills 36–33. Drive: 6 plays, 75 yards, 0:49.
KC – Harrison Butker 49-yard field goal, 0:00. Tied 36–36. Drive: 3 plays, 44 yards, 0:13.
Overtime
KC – Travis Kelce 8-yard pass from Patrick Mahomes, 10:45. Chiefs 42–36. Drive: 8 plays, 75 yards, 4:15.
Top passers
BUF – Josh Allen – 27/37, 329 yards, 4 TD
KC – Patrick Mahomes – 33/44, 378 yards, 3 TD
Top rushers
BUF – Josh Allen – 11 rushes, 68 yards
KC – Patrick Mahomes – 7 rushes, 69 yards, TD
Top receivers
BUF – Gabe Davis – 8 receptions, 201 yards, 4 TD
KC – Tyreek Hill – 11 receptions, 150 yards, TD :
After a back-and-forth first half, Kansas City took a 9-point lead in the third quarter with a Mecole Hardman rushing touchdown before Buffalo struck back on the next play with a 75-yard touchdown pass from Josh Allen to Gabe Davis. The Chiefs led 26–21 in the 4th quarter after Tyreek Hill set up a field goal with a 45-yard punt return. Allen then led the Bills on an 7-minute, 75-yard drive to retake the lead, scoring the first 8 points of 25 by both teams in the final two minutes of the game; the lead would change twice afterwards, with Kansas City and Buffalo scoring quick touchdowns within seconds of each other.
Buffalo took a 36–33 lead with 13 seconds left, but controversially opted to eschew a squib kick for a traditional kickoff out of the endzone for a touchback setting up the Chiefs at their own 25-yard-line with all three of their timeouts remaining. Chiefs quarterback Patrick Mahomes completed a 19-yard pass to Hill that ran just 5 seconds off the clock, then threw a 25-yard pass to Travis Kelce, giving Kansas City a first down on the Bills 31-yard line after running down another 5 seconds. On the next play, Butker's 49-yard field goal sent the game into overtime.
Getting the ball first in overtime, Mahomes rushed for 4 yards and completed 5/5 passes for 50 yards, including a 16-yard pass to McKinnon and a 26-yard throw to Hardman. He finished the drive with an 8-yard touchdown pass to Kelce that sealed the win for Kansas City and eliminated the Bills from the playoffs for the second season in a row, ending their season.

## Statistics
### Team

| Category | Total yards | Yards per game | NFL rank (out of 32) |
| Passing offense | 4,284 | 252.0 | 9th |
| Rushing offense | 2,209 | 129.9 | 6th |
| Total offense | 6,493 | 381.9 | 5th |
| Passing defense | 2,771 | 163.0 | 1st |
| Rushing defense | 1,866 | 109.8 | 13th |
| Total defense | 4,637 | 272.8 | 1st |

### Individual

| Category | Player | Total yards |
| Offense |||
| Passing | Josh Allen | 4,407 |
| Rushing | Devin Singletary | 870 |
| Receiving | Stefon Diggs | 1,225 |
| Defense |||
| Tackles (Solo) | Tremaine Edmunds | 70 |
| Sacks | Mario Addison | 7 |
| Interceptions | Micah Hyde | 5 |
Statistics correct as of the end of the 2021 NFL season