# List of signaling peptide/protein receptor modulators

This is a list of signaling peptide/protein receptor modulators

## Adiponectin
### AdipoR$_1$

* Agonists: Peptide: Adiponectin
* ADP-355
* ADP-399; Non-peptide: AdipoRon
* (–)-Arctigenin
* Arctiin
* Gramine
* Matairesinol
* Antagonists: Peptide: ADP-400

### AdipoR$_2$

* Agonists: Peptide: Adiponectin
* ADP-355
* ADP-399; Non-peptide: AdipoRon
* Deoxyschizandrin
* Parthenolide
* Syringing
* Taxifoliol
* Antagonists: Peptide: ADP-400

## Angiotensin

* See here instead.

## Bradykinin

* Agonists: Bradykinin
* Kallidin
* Antagonists: FR-173657
* Icatibant
* LF22-0542

## Calcitonin gene-related peptide receptor

* Agonists: Amylin
* CGRP
* Pramlintide
* Antagonists: Atogepant
* BI 44370 TA
* CGRP (8-37)
* MK-3207
* Olcegepant
* Rimegepant
* SB-268262
* Telcagepant
* Ubrogepant
* Antibodies: Eptinezumab
* Erenumab
* Fremanezumab
* Galcanezumab

## Cholecystokinin
### CCK$_A$

* Agonists: Cholecystokinin
* Antagonists: Amiglumide
* Asperlicin
* Devazepide
* Dexloxiglumide
* Lintitript
* Lorglumide
* Loxiglumide
* Pranazepide
* Proglumide
* Tarazepide
* Tomoglumide

### CCK$_B$

* Agonists: Cholecystokinin
* CCK-4
* Gastrin
* Pentagastrin (CCK-5)
* Antagonists: Ceclazepide
* CI-988 (PD-134308)
* Itriglumide
* L-365,360
* Netazepide
* Proglumide
* Spiroglumide

### Unsorted

* Antagonists: Nastorazepide

## Corticotropin-releasing hormone receptor
### CRF$_1$

* Agonists: Cortagine
* Corticorelin
* Corticotropin-releasing hormone
* Sauvagine
* Stressin I
* Urocortin
* Antagonists: Antalarmin
* Astressin-B
* CP-154,526
* Emicerfont
* Hypericin
* LWH-234
* NBI-27914
* NBI-74788
* Pexacerfont
* R-121919
* TS-041
* Verucerfont

### CRF$_2$

* Agonists: Corticorelin
* Corticotropin-releasing hormone
* Sauvagine
* Urocortin
* Antagonists: Astressin-B

## Cytokine

See here instead.

## Endothelin

* Agonists: Endothelin 1
* Endothelin 2
* Endothelin 3
* IRL-1620
* Sarafotoxin
* Antagonists: A-192621
* Ambrisentan
* Aprocitentan
* Atrasentan
* Avosentan
* Bosentan
* BQ-123
* BQ-788
* Clazosentan
* Darusentan
* Edonentan
* Enrasentan
* Fandosentan
* Feloprentan
* Macitentan
* Nebentan
* Sitaxentan
* Sparsentan
* Tezosentan
* Zibotentan

## Galanin
### GAL$_1$

* Agonists: Galanin
* Galanin (1-15)
* Galanin-like peptide
* Galmic
* Galnon
* NAX 810-2
* Antagonists: C7
* Dithiepine-1,1,4,4-tetroxide
* Galantide (M15)
* M32
* M35
* M40
* SCH-202596

### GAL$_2$

* Agonists: Galanin
* Galanin (1-15)
* Galanin (2-11)
* Galanin-like peptide
* Galmic
* Galnon
* J18
* NAX 810-2
* Antagonists: C7
* Galantide (M15)
* M32
* M35
* M40
* M871

### GAL$_3$

* Agonists: Galanin
* Galanin (1-15)
* Galmic
* Galnon
* Antagonists: C7
* Galantide (M15)
* GalR3ant
* HT-2157
* M32
* M35
* M40
* SNAP-37889
* SNAP-398299

## Ghrelin/GHS

* See here instead.

## GH

* See here instead.

## GHRH

* See here instead.

## GLP
### GLP-1

* Agonists: Albiglutide
* Beinaglutide
* Dulaglutide
* Efpeglenatide
* Exenatide
* GLP-1
* Langlenatide
* Liraglutide
* Lixisenatide
* Oxyntomodulin
* Pegapamodutide
* Semaglutide
* Taspoglutide

### GLP-2

* Agonists: Apraglutide
* Elsiglutide
* Glepaglutide
* GLP-2
* Teduglutide

### Others

* Propeptides: Preproglucagon
* Proglucagon

## Glucagon

* Agonists: Dasiglucagon
* Glucagon
* Oxyntomodulin
* Antagonists: Adomeglivant
* L-168,049
* LGD-6972
* Propeptides: Preproglucagon
* Proglucagon

## GnRH

* See here instead.

## Gonadotropin

* See here instead.

## Growth factor

* See here instead.

## Insulin

* Agonists: Chaetochromin (4548-G05)
* Insulin-like growth factor 1
* Insulin-like growth factor 2
* Insulin
* Insulin aspart
* Insulin degludec
* Insulin detemir
* Insulin glargine
* Insulin glulisine
* Insulin lispro
* Mecasermin
* Mecasermin rinfabate
* Antagonists: BMS-754807
* S661
* S961
* Kinase inhibitors: Linsitinib
* Antibodies: Xentuzumab (against IGF-1 and IGF-2)

## Kisspeptin

* Agonists: Kisspeptin
* Kisspeptin-10
* Antagonists: Kisspeptin-234

## Leptin

* Agonists: Leptin
* Metreleptin

## Melanin-concentrating hormone receptor
### MCH$_1$

* Agonists: Melanin-concentrating hormone
* Antagonists: ATC-0065
* ATC-0175
* GW-803430
* NGD-4715
* SNAP-7941
* SNAP-94847

### MCH$_2$

* Agonists: Melanin-concentrating hormone

## Melanocortin

* See here instead.

## mTOR

* Activators: beta-Hydroxy beta-methylbutyric acid
* Hydroxynorketamine
* Leucine
* NV-5138
* Inhibitors: Rapalogs: Everolimus
* Ridaforolimus
* Sirolimus (Rapamycin)
* Temsirolimus
* Umirolimus
* Zotarolimus; ATP-competitive / indirect: Berberine
* Curcumin
* Dactolisib
* EF-24
* Epigallocatechin gallate
* HY-124798
* NV-5440
* Pterostilbene
* Quercetin
* Resveratrol
* Sapanisertib
* Torin-1
* WYE-687
* XL-388

## Neuropeptide FF

* Agonists: Neuropeptide AF
* Neuropeptide FF
* Neuropeptide SF (RFRP-1)
* Neuropeptide VF (RFRP-3)
* Antagonists: BIBP-3226
* RF9

## Neuropeptide S

* Agonists: Neuropeptide S
* Antagonists: ML-154
* SHA-68

## Neuropeptide Y
### Y$_1$

* Agonists: Neuropeptide Y
* Peptide YY
* Antagonists: BIBO-3304
* BIBP-3226
* BVD-10
* GR-231118
* PD-160170

### Y$_2$

* Agonists: 2-Thiouridine 5'-triphosphate
* Neuropeptide Y
* Neuropeptide Y (13-36)
* Peptide YY
* Peptide YY (3-36)
* Antagonists: BIIE-0246
* JNJ-5207787
* SF-11

### Y$_4$

* Agonists: GR-231118
* Neuropeptide Y
* Pancreatic polypeptide
* Peptide YY
* Antagonists: UR-AK49

### Y$_5$

* Agonists: BWX-46
* Neuropeptide Y
* Peptide YY
* Antagonists: CGP-71683
* FMS-586
* L-152,804
* Lu AA-33810
* MK-0557
* NTNCB
* Velneperit (S-2367)

## Neurotensin
### NTS$_1$

* Agonists:
** Neurotensin
** Neuromedin N
* Antagonists:
** Meclinertant
** SR-142948

### NTS$_2$

* Agonists:
** Neurotensin
* Antagonists:
** Levocabastine
** SR-142948

## Opioid

* See here instead.

## Orexin
### OX$_1$

* Agonists: Orexin (A, B)
* Antagonists: ACT-335827
* ACT-462206
* Almorexant
* Filorexant
* Lemborexant
* Nemorexant
* RTIOX-276
* SB-334867
* SB-408124
* SB-649868
* Suvorexant
* TCS-1102

### OX$_2$

* Agonists: Orexin (A, B)
* SB-668875
* Antagonists: ACT-335827
* ACT-462206
* Almorexant
* EMPA
* Filorexant
* JNJ-10397049
* Lemborexant
* MK-1064
* SB-649868
* Seltorexant
* Suvorexant
* TCS-1102
* TCS-OX2-29

## Oxytocin

* See here instead.

## Prolactin

* Agonists: Growth hormone
* Human placental lactogen
* Placental growth hormone (growth hormone variant)
* Prolactin
* S179D-hPRL
* Somatotropin
* Antagonists: Δ1–9-G129R-hPRL
* Δ1–14-G129R-hPRL
* G120K-hGH
* G129R-hPRL
* Prolactin modulators: Prolactin inhibitors: D$_2$ receptor agonists (e.g., bromocriptine, cabergoline); Prolactin releasers: D$_2$ receptor antagonists (e.g., domperidone, metoclopramide, risperidone)
* Estrogens (e.g., estradiol)
* Progestogens (e.g., progesterone)

## PTH

* Agonists: Abaloparatide
* Parathyroid hormone
* Parathyroid hormone-related protein (PTHrP)
* Semparatide
* Teriparatide

## Relaxin

* Agonists: Insulin-like factor 3
* Relaxin (1, 2, 3)
* Serelaxin

## Somatostatin

* See here instead.

## Tachykinin

* See here instead.

## TRH

* Agonists: Azetirelin
* Fertirelin
* Montirelin
* Orotirelin
* Posatirelin
* Protirelin
* Rovatirelin
* Taltirelin
* TRH (TRF)

## TSH

* Agonists: Thyrotropin alfa
* TSH (thyrotropin)

## Vasopressin

* See here instead.

## VIP/PACAP
### VIPR$_1$

* Agonists: Peptide: Bay 55-9837
* LBT-3393
* PACAP
* VIP

### VIPR$_2$

* Agonists: Peptide: LBT-3627
* PACAP
* VIP

### PAC$_1$

* Agonists: PACAP
* PACAP (1-27)
* PACAP (1-38)
* Antagonists: PACAP (6-38)

### Unsorted

* PHI
* PHM
* PHV

## Others

* Endogenous: Adrenomedullin
* Apelin
* Asprosin
* Bombesin
* Calcitonin
* Carnosine
* CART
* CLIP
* DSIP
* Enteroglucagon
* Formyl peptide
* GALP
* GIP
* GRP
* Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin)
* Kininogens
* Motilin
* Natriuretic peptides (ANP, BNP, CNP, urodilatin)
* Nesfatin-1
* Neuromedin B
* Neuromedin N
* Neuromedin S
* Neuromedin U
* Obestatin
* Osteocalcin
* Resistin
* Secretin
* Thymopoietin
* Thymosins
* Thymulin
* Urotensin-II
* VGF
* Exogenous: Lifitegrast (LFA-1 antagonist)