OpenLLM-France/wikimedia huggingface dataset:
# C-C chemokine receptor type 6

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,494 Da).

## Function

This protein belongs to family A of G protein-coupled receptor superfamily. The gene is expressed in lymphatic and non-lymphatic tissue as spleen, lymph nodes, pancreas, colon, appendix, small intestine. CCR6 is expressed on B-cells, immature dendritic cells (DC), T-cells (Th1, Th2, Th17, Treg), natural killer T cells (NKT cells) and neutrophils. The ligand of this receptor is CCL20 or in the other name - macrophage inflammatory protein 3 alpha (MIP-3 alpha). This chemokine receptor is special because it binds only one chemokine ligand CCL20 in comparison to other chemokine receptors. CCR6 has a key role between immature DC and adaptive immunity. This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic cells and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
Interleukin 4 (IL-4) and interferon gamma (IFNγ) suppress expression of CCR6 in langerhans cells development and interleukin 10 (IL-10) induces the expression. It can regulate immune response in inflammatory tissue.
Proinflammatory Th17 cells express CCR6 and its ligand CCL20. CCR6 influences their migration to sites of inflammation. Some Th17 cells migrate via chemokine gradient of CCL20 to inflammatory sites and themselves can express more CCL20 to bring in more Th17 cells and regulatory T-cells (Treg). This can lead to chronic inflammation. In some models, the lack of CCR6 leads to less severe autoimmune encephalomyelitis.

## Clinical significance

CCR6 has a function in development and metastatic spread of gastrointestinal malignancies. Expression of CCR6 was found to be up-regulated in colorectal cancer. Many patients with colorectal cancer have liver metastases. Colorectal carcinoma cells express CCR6 and CCL20. High level of CCL20 in liver chemoattract colorectal carcinoma cells and cause metastases in liver. Novel research has identified a microRNA that is able to downregulate CCR6 in cancer cell lines.
CCR6 has been associated with Crohn's disease.
# United Nations Security Council Resolution 1665

United Nations Security Council Resolution 1665, adopted unanimously on March 29, 2006, after recalling previous resolutions on the situation in Sudan, particularly resolutions 1556 (2004), 1591 (2005) and 1651 (2005), extended the mandate of an expert panel monitoring sanctions against and violations of human rights in the Darfur region until September 29, 2006.

## Observations

The Security Council stressed its commitment to peace in Sudan, the implementation of the Comprehensive Peace Agreement and the end of the violations in the Darfur region. It emphasised the need for respecting elements of the United Nations Charter, including those relating to the Convention on the Privileges and Immunities. Council members stated that the situation continued to constitute a threat to international peace and security in the region.

## Acts

The resolution, enacted under Chapter VII of the United Nations Charter, extended the expert panel established in Resolution 1591 and extended by Resolution 1651 until September 29, 2006 and requested it to report on the implementation of the sanctions and observations on human rights. All relevant United Nations bodies, the African Union and others were urged to co-operate with the expert panel and the Committee established in Resolution 1591.
# Irving Terjesen

Irving Bernhard Terjesen (March 4, 1915 – April 12, 1990) was an American basketball player. An All-American college player at New York University, Terjesen played three seasons in the United States' National Basketball League (NBL).
Terjesen played in his native Brooklyn for James Madison High School, then played four seasons for Howard Cann's NYU Violets, where he was the leading scorer for two seasons. After the close of his college career, Terjesen played for the NBL's Akron Firestone Non-Skids from 1938 to 1941. The Firestone Non-Skids won the National Basketball League championships in both 1938–39 and 1939–40. In 63 career NBL appearances, Terjesen averaged 3.1 points per game. He was also known by the nicknames "Rip" and "Swede." He was inducted into the Summit County Athletic Hall of Fame in 1981.
# Five Young American Poets

Five Young American Poets was a three volume series of poetry anthologies released from 1940 to 1944. The series was published by New Directions Publishers (Norfolk, Connecticut; James Laughlin, publisher).
Volume I - 1940 includes selected poetry by:
* W. R. Moses
* Randall Jarrell
* George Marion O'Donnell
* John Berryman
* Mary Barnard
Reviews.
Volume II - 1941 includes selected poetry by:
* Clark Mills
* Karl Shapiro
* David Schubert
* Jeanne McGahey
* Paul Goodman
Volume III - 1944 includes selected poetry by:
* Eve Merriam
* John Frederick Nims
* Jean Garrigue
* Tennessee Williams
* Alejandro Carrión
# The Pioneer (India)

The Pioneer is an English-language daily newspaper in India. It is published from multiple locations in India, including Delhi. It is the second-oldest English-language newspaper in India still in circulation after The Times of India. In 2010, The Pioneer launched its Hindi version in Lucknow.

## History

The Pioneer was founded in Allahabad in 1865, by George Allen, an Englishman who had great success in the tea business in north-east India in the previous decade. It was brought out three times a week from 1865 to 1869 and daily thereafter. In 1866, a supplement, the Pioneer Mail, consisting of "48 quarto-size pages," mostly of advertisements, was added to the publication. In 1872, Alfred Sinnett became the editor of the newspaper. Although he was later to be known for his interest in theosophy, he oversaw the transformation of the newspaper to one of exercising great influence in British India. In 1874, the weekly Pioneer Mail became the Pioneer Mail and India Weekly News and began to also feature short stories and travel writings. Author Rudyard Kipling (1865–1936), in his early 20s, worked at the newspaper office in Allahabad as an assistant editor from November 1887 to March 1889. In July 1933, The Pioneer was sold to a syndicate and moved from Allahabad to Lucknow, Uttar Pradesh, at which time the Pioneer Mail and India Weekly News ceased publication.
The newspaper remained a primarily Lucknow-based paper until 1990, when it was purchased by the Thapar Group, under L. M. Thapar, who made it a national newspaper, published from Delhi, Lucknow, Bhubaneswar, Kochi, Bhopal, Chandigarh, Dehradun and Ranchi. Thapar sold the paper to its editor Chandan Mitra in 1998. At that time it had 484 employees. Mitra announced that he intended to seek other investors in due course rather than to remain the owner. On 17 October 2010, The Pioneer launched its Hindi version of the newspaper from Lucknow and in May 2012, the paper inaugurated its Raipur bureau, beginning operations of its Chhattisgarh edition.
As of 2013, Chandan Mitra was the Editor-in-Chief of The Pioneer. He resigned as printer and publisher in June 2021, and died in September 2021. Also, the senior journalist Siddharth Mishra worked as an associate editor at The Pioneer.

### Editions

* Bhopal
* Bhubaneshwar
* Chandigarh
* Delhi
* Dehradun
* Hyderabad
* Lucknow
* Raipur
* Ranchi
* Vijayawada
Lucknow edition includes four other editions Varanasi, Kanpur, Allahabad and Lucknow itself.

## Columnists

* Chandan Mitra (former)
* Kanchan Gupta
* Balbir Punj
* K G Suresh
* KPS Gill
* Kalyani Shankar
* Gyaneshwar Dayal
* Ashok K Mehta
* Nilantha Ilangamuwa

### Cartoonists

* Sudhir Dar (former)
* Shekhar Gurera
* Irfan Hussain (former)
# Velykyi Kuialnyk

The Velykyi Kuialnyk (Ukrainian: Великий Куяльник) or Bolshoy Kuyalnik (Russian: Большой Куяльник) is a river in Podilsk and Berezivka Raions of Odesa Oblast, Ukraine. It flows into the Kuialnyk Estuary of the Black Sea. The river spans 150 kilometres (93 mi), with a drainage basin covering 1,860 square kilometres (720 sq mi). The urban-type settlements of Shyriaieve and Ivanivka are located along its banks.
Historically, the Velykyi Kuialnyk was navigable and, along with the Dniester, served as a route for transporting goods to the Black Sea, bypassing the cascades of the Dnieper River. However, in 2007–2008, illegal sand diggers constructed a dam at the river’s mouth, which prevented it from emptying into the sea. The dam has not been removed, resulting in the gradual drying of the estuary.
# Pratishtha Raut

Pratishtha Raut (Nepali: प्रतिष्ठा राउत; born 19 March 1993) also widely known as Trish, is a British beauty pageant title holder who won the title Miss England 2019/20 2nd Runner Up which makes her the first British-Nepali origin beauty queen to hold the highest title among the Nepalese Community in United Kingdom.

## Early life and family background

Raut was born in Kowloon, Hong Kong raised in England and of a Nepali origin. She is a daughter of ex-Royal Gurkha Rifles Prakash Raut and Mina Raut. Her father, Prakash Raut is a retired 10 Queen's Own Gurkha Logistic Regiment RLC army. She has an older brother Dr. Pramin Raut. She spent the majority of her life travelling between countries and cities which meant she never studied in the same school for over three years.

## Personal life

Raut started modelling at the age of 16 as a hobby but chose to focus on her studies more. Due to her moving different countries and cities, Pratishtha can speak three languages fluently - English, Nepali and Hindi making her trilingual.

## Pageantry

Miss England 2019/20 was her first pageant she entered in with the intention of having a platform for raising awareness of Mental Health. She was the crowd's favourite since the beginning of the pageant. She had an outstanding performance in every round on the basis of which the panel of jury handed over the title of Beauty With A Purpose. She also won the titles of Miss Public's Choice and Miss Charity Queen in which she raised £9,999 for varies charities by holding a charity dinner attended by 300 guests which made her the top fundraiser. She won Miss England 2019/20 as the 2nd Runner Up in the competition at The Newbridge Hotel on 1 August 2019.
Raut was also a finalist at Miss Universe Great Britain 2020 but decided to withdraw from the competition due to the pandemic.

## Mental Health

Raut is an advocate for mental health. She mentions in one of her interviews that "There is a lot to take in as an immigrant because of clash in culture and crisis in identity but the support system for this seems to be lacking in our community. This needs to change and change fast because it will not only ruin lives of old and young but also create social instability for immigrants in the UK."
She managed to raise £9,999 for charities in 2019.
# 1842 Brighton by-election

The 1842 Brighton by-election was held on 5 May 1842 after the resignation of the incumbent Whig MP Isaac Newton Wigney. The seat was gained by the Conservative MP Lord Alfred Hervey.
Brighton by-election, 6 May 1842 :
| Party | Party | Candidate | Votes | % | ±% |
| | Conservative | Lord Alfred Hervey | 1,277 | 66.1 | +41.7 |
| | Radical | Summers Harford | 640 | 33.1 | −1.5 |
| | Chartist | Charles Brooker | 16 | 0.8 | +0.3 |
| | Independent | Nicholson | 0 | 0.0 | New |
| Majority | Majority | Majority | 637 | 33.0 | N/A |
| Turnout | Turnout | Turnout | 1,933 | 76.3 | −9.0 |
| | Conservative gain from Whig | Conservative gain from Whig | Swing | +21.6 | |
# Central Avenue School (Anderson, Indiana)

The Central Avenue School is a historic school building in Anderson, Indiana, United States. It was built in 1891, and is a two-story, Romanesque Revival style brick and stone building on a raised basement. The building features two three-story towers. Attached to the original building is a Bungalow / American Craftsman style addition constructed in 1921. The building housed a school until 1974.$^{:5,21}$
It was listed on the National Register of Historic Places in 2007.
# Robert LaClair

Robert A. LaClair (born July 21, 1959) is an American politician from Barre Town, Vermont. A Republican. He served in the Vermont House of Representatives from 2015 to 2023.
# Egon Schnabel

Egon Schnabel (born 19 May 1937) is a German biathlete. He competed in the 20 km individual event at the 1964 Winter Olympics.
# Karl-Heinz Wolf

Karl-Heinz Wolf (born 4 July 1951) is a German biathlete. He competed in the 20 km individual event at the 1976 Winter Olympics.
# Savona Mill

Savona Mill, also known as Savona Manufacturing Company, Alfred Cotton Mill, and Old Dominion Box Company, is a historic textile mill located at Charlotte, Mecklenburg County, North Carolina. The building consists of four sections, three of which are historic. They are the 1915-1916 Weave Mill, a one-story rectangular brick building with segmental arched head windows, a low gable roof with exposed beam ends and a wood clerestory monitor roof; the 1921 Spinning Mill, a three-story rectangular brick building with large rectangular steel windows; and the 1951 three-story Paper Warehouse addition. The Weave Mill was designed by Lockwood, Greene & Co.; Richard C. Biberstein designed the Spinning Mill.
It was added to the National Register of Historic Places in 2014.
The property is currently owned by an affiliate of Argos Real Estate Advisors, based in Charlotte, NC, and includes approximately 30 acres and 300,000 total square feet of improvements. Blue Blaze Brewing operates a 15-barrel production brewery with a tap room in an 8,000 SF building on the site.
# Sabine Kahle

Sabine Kahle (born 25 June 1959 in Meiningen) is a German retired swimmer who won two silver medals in medley events at the 1977 European Aquatics Championships. She also participated in the 1976 Summer Olympics and finished fifth in the 400 m medley and eighth in the 400 m freestyle.
# Raman

Raman may refer to:

## People

* Raman (name)
** C. V. Raman (1888–1970), Indian Nobel Prize-winning physicist
** Kocheril Raman Narayanan, President of India from 1997 to 2002

## Places

* Raman, Bathinda, India
* Raman, Rawalpindi, Pakistan
* Raman district, Yala Province, Thailand
** Raman railway station
* Raman oil field, in Batman, Turkey

## Other uses

* Raman (crater), a lunar impact crater
* Raman (film), a 2008 Indian Malayalam film
* Raman scattering, a physical effect named after C. V. Raman
* Raman spectroscopy, an analytical technique based on Raman Scattering
* Raman, a comic, and its title character, created by Pran Kumar Sharma
# Battle of Chapu

The Battle of Chapu was fought between British and Qing forces at Chapu (present-day Zhapu) on the northern shore of Hangzhou Bay during the First Opium War.

## Battle

Before the attack, the British commander, Major General Hugh Gough divided his forces into three: a column of infantry on the left (863 men) and right (969 men), with artillery in the centre. Gough accompanied the right column, which landed first on May 16. The remaining troops moved round to the rear of the enemy thereby cutting their communications with Zhapu. Meanwhile, the accompanying steamers began a bombardment of the city's defences. In Gough's own words: "The enemy were completely taken by surprise; as usual, they were unprepared for anything except a frontal attack. They gave way on all sides and took to flight, with the exception of a body of some 300 Tartar troops who seized a small joss-house, and held it with indomitable pluck and perseverance."
Multiple assaults proved necessary to capture the joss-house with casualties suffered on both sides; eventually it fell and after each of the gates had been captured, the city fell to the British. Not without cost and Gough lost one of his most accomplished field commanders Lieutenant Colonel Nicholas Tomlinson who was killed personally leading a breaching party of the 18th (Royal Irish) Regiment of Foot.

## Aftermath

The British did not remain in Zhapu long. They captured the city's ordnance and destroyed its arsenals before moving on to attack Wusong.
Hailing, the Manchu commander at Zhenjiang, received the report of Zhapu's surrender on June 18. The Manchus committed mass suicide while the Han Chinese discussed the situation with the British. When hostilities ceased, Chinese official Yilibu returned sixteen kidnapped British soldiers to Gough in "recognition of his courtesy in releasing the Chinese captured at Chapoo".

## Gallery

* Engagement at the joss house
* Joss House, Chapoo. Death of Col. Tomlinson
* Close of the attack on Chapu
# Pushkar Fair

The Pushkar Fair, also called the Pushkar Camel Fair or locally as Kartik Mela or Pushkar ka Mela is an annual multi-day livestock fair and cultural fête held in the town of Pushkar near Ajmer city in Ajmer district in (Rajasthan, India). The fair starts with the Hindu calendar month of Kartik and ends on the Kartik Purnima, which typically overlaps with late October and early November in the Gregorian calendar. In 1998, over 1 million visitors came to Pushkar throughout the year. The Pushkar fair alone attracts over 200,000 visitors.
The Pushkar fair is one of India's largest camel, horse and cattle fairs. Apart from the trading of livestock, it is an important pilgrimage season for Hindus to the Pushkar lake. Pushkar fair has also become a significant tourist attraction for domestic and international travellers, given the cooler season, the abundance of colourful cultural themes. Cultural events and competitions include dances, tug of war between women teams as well as men teams, the "matka phod", "longest moustache" competition, "bridal competition", camel races and others.
Thousands of people go to the banks of the Pushkar Lake where the fair takes place. Men trade their livestock, which includes camels, horses, cows, sheep and goats. Rural families shop at the handicraft stalls full of bracelets, clothes, textiles and fabrics. A camel race starts off the festival, with music, songs and exhibitions to follow. Between these events, the most waited for is the test of how the camel is able to bring the items. In order to demonstrate, the men go up on the group of camels one after another.
Pushkar is in centre-east part of Rajasthan, on the western side of Aravalli mountains. The nearest airport from Pushkar is Kishangarh Airport in Ajmer, about 40 km (25 mi) northeast. Jaipur is well connected with all the major cities in India. Pushkar is about 10 km (6.2 mi) from Ajmer, connected via Pushkar road (Highway 58) which goes over the Aravalli Range mountains. Ajmer is also the nearest major railway Station. Pushkar Railway Station is connected to Ajmer Railway Station.

## Crowd

Around 500,000-600,000 people visit Pushkar during the main Pushkar festival.
# Morton College

Morton College is a public community college in Cicero, Illinois. It is the second-oldest community college in the state only after Joliet Junior College. While the campus itself was constructed in 1975, the college was established in 1924. Before the construction of the campus, the college was housed in the same building as the local high school and was Morton Junior College. It is named after Julius Sterling Morton, a Nebraska newspaper editor and politician who served as President Grover Cleveland's Secretary of Agriculture.
Land was acquired for an athletics field in 1994. Intercollegiate athletics for men include baseball, basketball, soccer, and cross country. Women's sports include volleyball, basketball, cross country, soccer and softball.
The college is a National Alternative Fuels Training Consortium training center. It also operates a low-power FM station, WZQC-LP, at 99.1 MHz.
* Chicago portal
* Illinois portal
# Simone Palombi

Simone Palombi (born 23 April 1996) is an Italian professional footballer who plays as a forward for Serie C Group A club Alcione.

## Club career

Palombi made his professional debut in the Serie B for Ternana on 1 October 2016 in a game against Verona.
He made his Serie A debut for Lazio on 20 August 2017, when he started the game against SPAL.
On 19 July 2018, Palombi signed to Lecce on loan until 30 June 2019.
On 9 July 2019, Palombi joined to Serie B side Cremonese on loan with an option to buy.
On 24 September 2020 he moved on loan to Serie B club Pisa.
On 18 August 2021, he signed with Alessandria. On 3 August 2022, Palombi was loaned to Pordenone, with an option to buy.
On 21 August 2023, Palombi signed a two-year contract with Padova.

## International career

He made his debut with the Italy U21 team on 1 September 2017, in a friendly match against Spain.

## Honours

Lazio
* Supercoppa Italiana: 2017
# Marco Crocchianti

Marco Crocchianti (born 18 February 1996) is an Italian football player who plays for Spoleto.

## Club career

He made his professional debut in the Serie B for Spezia on 2 April 2016 in a game against Cagliari.
On 18 November 2021 he joined Ravenna in Serie D.
# Lake Waitaki

Lake Waitaki is the smallest, oldest and most downstream of the three man-made lakes on the Waitaki River, and forms part of the Waitaki hydroelectric scheme in New Zealand's South Island. It lies downstream of lakes Aviemore and Benmore on the Waitaki River, close to the town of Kurow. It is part of the traditional boundary of the Canterbury and Otago regions (although the official border has been moved southward to include the entire lake, as well as the entire northwest portion of the Waitaki District within the Canterbury Region.
The lake was created by the Waitaki Dam, a 36m high concrete gravity dam built between 1928 and 1934. Waitaki Dam was the first hydroelectric dam built on the Waitaki River. The Waitaki power station has a total installed capacity of 105MW.
Waitaki was the last dam built in New Zealand with excavation done with pick and shovel, not heavy machinery. The power station was to be upgraded by Meridian Energy between 2011 and 2016 at a projected cost of $NZ 60 – 80 million.
# La Jolla Beach Invitational

The La Jolla Beach Invitational was a combined USTA affiliated hard court tennis tournament founded in 1942. It was played at the La Jolla Beach and Tennis Club, a private members beach resort and tennis facility in La Jolla, California, United States until 1959. The tournament was part of the main ILTF World Circuit. The tournament was usually held in the first quarter of the year January to March annually.