# List of Intelligent Systems for Molecular Biology keynote speakers

The following is a list of Intelligent Systems for Molecular Biology (ISMB) keynote speakers.
ISMB is an academic conference on the subjects of bioinformatics and computational biology organised by the International Society for Computational Biology (ISCB). The conference has been held annually since 1993 and keynote talks have been presented since 1994. Keynotes are chosen to reflect outstanding research in bioinformatics. The recipients of the ISCB Overton Prize and ISCB Accomplishment by a Senior Scientist Award are invited to give keynote talks as part of the programme.
Keynote speakers include eight Nobel laureates: Richard J. Roberts (1994, 2006), John Sulston (1995), Manfred Eigen (1999), Gerald Edelman (2000), Sydney Brenner (2003), Kurt Wüthrich (2006), Robert Huber (2006) and Michael Levitt (2015).

## List of speakers

| Conference | Keynote speakers | Title | Notes |
| ISMB 1994 | Bruce Buchanan | | |
| ISMB 1994 | Lawrence Hunter | | Plenary speaker |
| ISMB 1994 | Richard J. Roberts | | Plenary speaker |
| ISMB 1995 | Douglas Brutlag | | |
| ISMB 1995 | John Sulston | | |
| ISMB 1995 | Janet Thornton | | |
| ISMB 1996 | Robert Waterston | | |
| ISMB 1996 | David Haussler | | |
| ISMB 1996 | Russell Doolittle | | |
| ISMB 1996 | Chris Sander | | |
| ISMB 1997 | Richard H. Lathrop | | |
| ISMB 1997 | Marcie McClure | | |
| ISMB 1997 | Hans Westerhoff | | |
| ISMB 1998 | Robert Cedergren | | |
| ISMB 1998 | Michael Waterman | | |
| ISMB 1998 | Shoshana Wodak | | |
| ISMB 1999 | Manfred Eigen | The Origin of Biological Information | |
| ISMB 1999 | Amos Bairoch | Swiss-Prot in the 21st century! | |
| ISMB 1999 | Richard M. Karp | Combinatorial Problems in Gene expression Analysis Using DNA microarrays | |
| ISMB 1999 | Anthony R. Kerlavage | Computational genomics: Biological Discovery in Complete Genomes | |
| ISMB 1999 | Eugene Koonin | Comparative genomics: Is it changing the paradigm of evolutionary biology? | |
| ISMB 1999 | David Balaban | Genes, Chips, and Genomes | |
| ISMB 1999 | Matthias Mann | Gene Function via the Mass Spectrometric Analysis of Multi-Protein Complexes |
| ISMB 1999 | Michael Sternberg | Exploiting Protein Structure in the Post-genome Era | |
| ISMB 2000 | Gerald Edelman | | |
| ISMB 2000 | Leroy Hood | | |
| ISMB 2000 | Minoru Kanehisa | | |
| ISMB 2000 | J. Andrew McCammon | | |
| ISMB 2000 | Eugene Myers | | |
| ISMB 2000 | Harold Scheraga | | |
| ISMB 2000 | David Searls | | |
| ISMB 2001 | Christopher Burge | | |
| ISMB 2001 | Chris Dobson | | |
| ISMB 2001 | Sean Eddy | | |
| ISMB 2001 | David Eisenberg | | |
| ISMB 2001 | Bernardo Huberman | | |
| ISMB 2001 | Chris Sander | | |
| ISMB 2001 | Gunnar von Heijne | | |
| ISMB 2002 | Stephen Altschul | Assessing the accuracy of database search methods, and improving the performance of PSI-BLAST | |
| ISMB 2002 | Michael Ashburner | | |
| ISMB 2002 | Ford Doolittle | | |
| ISMB 2002 | Terry Gaasterland | | |
| ISMB 2002 | Barry Honig | | |
| ISMB 2002 | David Baker | | 2002 ISCB Overton Prize winner |
| ISMB 2002 | John Reinitz | | |
| ISMB 2002 | Isidore Rigoutsos | | |
| ISMB 2003 | Sydney Brenner | The Evolution of Genes and Genomes | |
| ISMB 2003 | David Haussler | Identifying functional elements in the human genome by tracing the evolutionary history of the bases: a key challenge for comparative genomics | |
| ISMB 2003 | Yoshihide Hayashizaki | Dynamic Eukaryotic Transcriptome | |
| ISMB 2003 | Jim Kent | Patching and Painting the Human Genome | 2003 ISCB Overton Prize winner |
| ISMB 2003 | John Mattick | Programming of the autopoietic development of complex organisms: the hidden layer of noncoding RNA | |
| ISMB 2003 | David Sankoff | The Parameters of Genome Rearrangement | 2003 ISCB Senior Scientist Award winner |
| ISMB 2003 | Ron Shamir | Reconstructing Genetic Networks | |
| ISMB 2003 | Michael Waterman | Dynamic Programming Algorithms for Haplotype Block Partitioning | |
| ISMB/ECCB 2004 | Leroy Hood | Systems Biology: Strategies for Deciphering Life | |
| ISMB/ECCB 2004 | Denis Noble | Computational systems biology of the heart | |
| ISMB/ECCB 2004 | Eric D. Green | Decoding the Human Genome by Multi-Species Sequence Comparisons | |
| ISMB/ECCB 2004 | Svante Pääbo | Evolution of the primate transcriptome | |
| ISMB/ECCB 2004 | Matthias Mann | Organellar and time resolved proteomics | |
| ISMB/ECCB 2004 | Anna Tramontano | Progress, assessment and perspectives in protein structure prediction | |
| ISMB/ECCB 2004 | Uri Alon | Simplicity in complex biological networks | 2004 ISCB Overton Prize winner |
| ISMB/ECCB 2004 | David J. Lipman | Message and meaning in sequence comparison: is systems biology possible? | 2004 ISCB Senior Scientist Award winner |
| ISMB 2005 | Howard Cash | Biology of Life and Death: Disaster, DNA and the Information Science of Human Identification | |
| ISMB 2005 | Gunnar von Heijne | Membrane Proteins in vivo and in silico - Getting the Best of Two Worlds | |
| ISMB 2005 | Jill Mesirov | Gene Expression Analysis: A Knowledge-based Approach | |
| ISMB 2005 | Pavel A. Pevzner | Transforming Men into Mice: Fragile versus Random Breakage Models of Chromosome Evolution | |
| ISMB 2005 | Peter Hunter | Computational Physiology and the IUPS Physiome Project | |
| ISMB 2005 | Satoru Miyano | Computational Challenges for Gene Networks | |
| ISMB 2005 | Ewan Birney | Genomes to Systems Biology | 2005 ISCB Overton Prize winner |
| ISMB 2005 | Janet Thornton | From Proteins to Life - Old and New Challenges | 2005 ISCB Senior Scientist Award winner |
| ISMB 2006 | Robert Huber | Molecular machines for protein degradation | |
| ISMB 2006 | Tom Blundell | Structural biology, informatics and the discovery of new medicines | |
| ISMB 2006 | Kurt Wüthrich | Computational Aspects of NMR Studies with Proteins in Solution | |
| ISMB 2006 | Mathieu Blanchette | What mammalian genomes tell us about our ancestors, and vice versa | 2006 ISCB Overton Prize winner |
| ISMB 2006 | Elena Conti | Molecular mechanisms in RNA degradation | |
| ISMB 2006 | Charles DeLisi | New Approaches to Biomarker Discovery | |
| ISMB 2006 | Richard J. Roberts | The need of Bioinformatics for experimental biologists | |
| ISMB 2006 | Michael Waterman | Whole Genome Optical Mapping | 2006 ISCB Senior Scientist Award winner |
| ISMB/ECCB 2007 | Eran Segal | Quantitative Models for Chromatin and Transcription Regulation | 2007 ISCB Overton Prize winner |
| ISMB/ECCB 2007 | Temple F. Smith | Computational Biology: What is next? | 2007 ISCB Senior Scientist Award winner |
| ISMB/ECCB 2007 | Søren Brunak | Understanding interactomes by data integration | |
| ISMB/ECCB 2007 | Stephen K. Burley | Fragment-based discovery of BCR-ABL inhibitors for treatment of chronic myelogenous leukemia | |
| ISMB/ECCB 2007 | Michael Eisen | Understanding and exploiting the evolution of the sequences that control gene expression | |
| ISMB/ECCB 2007 | Anne-Claude Gavin | Interaction Networks Probed by Mass Spectrometry | |
| ISMB/ECCB 2007 | John Mattick | The majority of the genome of complex organisms is devoted to an RNA regulatory system that directs differentiation and development | |
| ISMB/ECCB 2007 | Erin K. O'Shea | Dissecting Transcriptional Network Structure and Function | |
| ISMB/ECCB 2007 | Renée Schroeder | Genomic SELEX for the identification of novel non-coding RNAs independent of their expression level | |
| ISMB/ECCB 2007 | Terry Speed | Genome-wide genotyping: the great classification challenge | |
| ISMB 2008 | Aviv Regev | Modular biology: the function and evolution of molecular networks | 2008 ISCB Overton Prize winner |
| ISMB 2008 | David Haussler | 100 Million Years of Evolutionary History of the Human Genome | 2008 ISCB Senior Scientist Award winner |
| ISMB 2008 | Claire M. Fraser-Liggett | Microbial Communities in Health and Disease | |
| ISMB 2008 | David Jaffe | Tiny bits and pieces: new sequencing technologies and what they can do for you | |
| ISMB 2008 | Eugene Myers | Imaging Bioinformatics | |
| ISMB 2008 | Morag Park | Profiling the Breast Tumor Microenvironment | |
| ISMB 2008 | Bernhard Palsson | Systems Biology: an era of reconstruction and interrogation | |
| ISMB 2008 | Hanah Margalit | Intriguing roles for small non-coding RNAs in the cellular regulatory networks | |
| ISMB/ECCB 2009 | Trey Ideker | New Challenges and Opportunities in Network Biology | 2009 ISCB Overton Prize winner |
| ISMB/ECCB 2009 | Webb Miller | Bioinformatics Methods to Study Species Extinctions | 2009 ISCB Senior Scientist Award winner |
| ISMB/ECCB 2009 | Pierre-Henri Gouyon | Information and Biology | |
| ISMB/ECCB 2009 | Daphne Koller | Individual Genetic Variation: From Networks to Mechanisms | |
| ISMB/ECCB 2009 | Thomas Lengauer | Chasing the AIDS Virus | |
| ISMB/ECCB 2009 | Eugenia María del Pino Veintimilla | The comparative analysis reveals independence of developmental processes during early development in frogs | |
| ISMB/ECCB 2009 | Tomaso Poggio | Computational Neuroscience: Models of the Visual System | |
| ISMB/ECCB 2009 | Mathias Uhlén | A global view on protein expression based on the Human Protein Atlas | |
| ISMB 2010 | Steven E. Brenner | Ultraconserved nonsense: gene regulation by splicing & RNA surveillance | 2010 ISCB Overton Prize winner |
| ISMB 2010 | Susan Lindquist | Protein Folding and Environmental Stress REDRAW the Relationship between Genotype and Phenotype | |
| ISMB 2010 | Svante Pääbo | Analyses of Pleistocene Genomes | |
| ISMB 2010 | Chris Sander | Systems Biology of Cancer Cells | 2010 ISCB Senior Scientist Award winner |
| ISMB 2010 | David Altshuler | Genomic Variation and the Inherited Basis of Common Disease | |
| ISMB 2010 | George M. Church | BI/O: Reading and Writing Genomes | |
| ISMB 2010 | Robert Weinberg | Cancer Stem Cells and the Evolution of Malignancy | Special Public Lecture |
| ISMB/ECCB 2011 | Bonnie Berger | Computational biology in the 21st century: making sense out of massive data | |
| ISMB/ECCB 2011 | Olga Troyanskaya | Integrating computation and experiments for a molecular-level understanding of human disease | 2011 ISCB Overton Prize winner |
| ISMB/ECCB 2011 | Janet Thornton | The Evolution of Enzyme Mechanisms and Functional Diversity | ECCB 10th Anniversary Keynote |
| ISMB/ECCB 2011 | Alfonso Valencia | Challenges for Bioinformatics in Personalized Cancer Medicine | 2011 ISCB Fellow |
| ISMB/ECCB 2011 | Luis Serrano | M. pneumoniae (Towards a full quantitative understanding of a free-living system) | |
| ISMB/ECCB 2011 | Michael Ashburner | From sequences to ontologies - adventures in informatics | 2011 ISCB Senior Scientist Award winner |
| ISMB 2012 | Richard H. Lathrop & Lawrence Hunter | Seeing forward by looking back | ISMB 20th Anniversary Keynote |
| ISMB 2012 | Ziv Bar-Joseph | Data integration for understanding dynamic biological systems | 2012 ISCB Overton Prize winner |
| ISMB 2012 | Barbara Wold | Analysis of transcriptome structure and chromatin landscapes | |
| ISMB 2012 | Richard M. Durbin | Progress, challenges and opportunities in population genome sequencing | 2012 ISCB Fellow |
| ISMB 2012 | Andrej Šali | Integrative Structural Biology | |
| ISMB 2012 | Gunnar von Heijne | The other Third: Coming to grips with membrane proteins | 2012 ISCB Senior Scientist Award winner |
| ISMB/ECCB 2013 | Gil Ast | How Chromatin organization and epigenetics talk with alternative splicing | |
| ISMB/ECCB 2013 | Gonçalo Abecasis | Insights from Sequencing Thousands of Human Genomes | 2013 ISCB Overton Prize winner |
| ISMB/ECCB 2013 | Lior Pachter | Sequencing based functional genomics (analysis) | |
| ISMB/ECCB 2013 | Gary Stormo | Searching for Signals in Sequences | 2013 ISCB Fellow |
| ISMB/ECCB 2013 | Carole Goble | Results may vary: what is reproducible? why do open science and who gets the credit? | |
| ISMB/ECCB 2013 | David Eisenberg | Protein Interactions in Health and Disease | 2013 ISCB Senior Scientist Award winner |
| ISMB 2014 | Isaac Kohane | Biomedical Quants of the World Unite! We only have our disease burden to lose | |
| ISMB 2014 | Eugene Myers | DNA Assembly: Past, Present, and Future | 2014 ISCB Senior Scientist Award winner |
| ISMB 2014 | Michal Linial | Good Things Come in Small Packages – Replicators and Innovators | |
| ISMB 2014 | Dana Pe'er | A multidimensional single cell approach to understand cellular behavior | 2014 ISCB Overton Prize winner |
| ISMB 2014 | Robert S. Langer | Biomaterials and biotechnology: From the discovery of the first angiogenesis inhibitors to the development of controlled drug delivery systems and the foundation of tissue engineering | |
| ISMB 2014 | Russ Altman | Informatics for understanding drug response at all scales | 2014 ISCB Fellow |
| ISMB 2015 | Michael Levitt | Birth & Future of Multiscale Modeling of Macromolecules | |
| ISMB 2015 | Curtis Huttenhower | Understanding microbial community function and the human microbiome in health and disease | 2015 ISCB Overton Prize winner |
| ISMB 2015 | Eileen Furlong | Genome regulation during embryonic development | |
| ISMB 2015 | Kenneth H Wolfe | TBA | |
| ISMB 2015 | Cyrus Chothia | TBA | 2015 ISCB Senior Scientist Award winner |
| ISMB 2015 | Amos Bairoch | TBA | 2015 ISCB Fellow |
| ISMB 2016 | Ruth Nussinov | Ras signaling: a challenge to the biological sciences | 2016 ISCB Fellow |
| ISMB 2016 | Debora Marks | | 2016 ISCB Overton Prize winner |
| ISMB 2016 | Sandrine Dudoit | Identification of Novel Cell Types in the Brain Using Single-Cell Transcriptome Sequencing | |
| ISMB 2016 | Sarah Teichmann | Understanding Cellular Heterogeneity | |
| ISMB 2016 | Serafim Batzoglou | | 2016 ISCB Innovator Award winner |
| ISMB 2016 | Søren Brunak | | 2016 ISCB Senior Scientist Award winner |