OpenLLM-France/wikimedia huggingface dataset:
# Mizonokuchi Station

Mizonokuchi Station (溝の口駅, Mizonokuchi-eki) is a junction passenger railway station located in Takatsu-ku, Kawasaki, Kanagawa Prefecture, Japan, operated by the private railway operator Tokyu Corporation.

## Lines

Mizonokuchi Station is served by the Tōkyū Den-en-toshi Line and Tōkyū Ōimachi Line. It is 11.4 kilometers from the starting point of the Tōkyū Den-en-toshi Line at Shibuya Station, and is the starting point of Tōkyū Ōimachi Line services, which branch off at Futako-tamagawa Station. Musashi-Mizonokuchi Station on the JR East Nambu Line is located adjacent to it.

## Station layout

Mizonokuchi Station has two opposed elevated island platforms serving four tracks. The platforms are connected to the station building by underpasses.

### Platforms

| 1 | DT Tōkyū Den-en-toshi Line | for Nagatsuta and Chūō-rinkan |
| 2 | OM Tōkyū Ōimachi Line | alighting (disembarking) only |
| 3 | OM Tōkyū Ōimachi Line | for Futako-tamagawa, Jiyūgaoka, and Ōimachi |
| 4 | DT Tōkyū Den-en-Toshi Line | for Futako-tamagawa and Shibuya Z Tokyo Metro Hanzomon Line for Oshiage TS Tobu Skytree Line for Tōbu-Dōbutsu-Kōen TI Tobu Isesaki Line for Kuki TN Tobu Nikko Line for Minami-Kurihashi |

## History

Mizonokuchi Station opened on July 15, 1927, with the name in Japanese originally written as (溝ノ口駅). The Japanese name was changed to the present format on January 20, 1966. Initially built with a single side platform, the station was expanded in 1992 to four tracks and two island platforms.

## Passenger statistics

In fiscal 2019, the station was used by an average of 155,777 passengers daily for the Den-en-Toshi Line and 57,731 passengers daily for the Ōimachi Line
The daily average passenger figures for previous years are as shown below.
| Fiscal year | Den-en-Toshi Line | Ōimachi Line |
| 2005 | 160,957 | NA |
| 2010 | 145,557 | 40,123 |
| 2015 | 153,059 | 52,138 |

## Surrounding area

* Musashi-Mizonokuchi Station
# Johannes Bouwmeester

Johannes Bouwmeester (4 November 1634 - buried 22 October 1680) was a Dutch physician, philosopher and a founding member of the literary society Nil volentibus arduum. He enrolled at Leiden University in 1651 and in 1658 graduated there in medicine. He was a close friend of Lodewijk Meyer, co-founder of Nil volentibus arduum, and acquainted with the philosophers Benedictus de Spinoza and Adriaen Koerbagh. His father, Claes Bouwmeester, was tailor by trade and several family members were builders of musical instruments. He was born in Amsterdam.
At least one letter by Spinoza to Bouwmeester (no. 37) is known and another letter to an anonymous correspondent may also have been addressed at him (no. 28), although this is generally inaccurately stated as a fact in most editions of Spinoza's correspondence. In 1663 he wrote a Latin poem for Spinoza's Renati Descartes principia philosophiae and he is also believed to be the author of the small poem under the engraved portrait of Spinoza found in some editions of the Opera posthuma (1677). In the second half of the 1660s he traveled to Italy, where on 30 September 1667 he enrolled in law at the University of Padua. In 1672 he translated the philosophical novel Het leeven van Hai Ebn Yokdhan, based on an earlier Latin translation by Edward Pococke, and published in Amsterdam by Jan Rieuwertsz. Bouwmeester was also involved in the publication of Spinoza's works.
# Netherlands Antilles at the 1972 Summer Olympics

The Netherlands Antilles competed at the 1972 Summer Olympics in Munich, West Germany. Two competitors, both men, took part in two events in two sports.

## Shooting

One shooter represented the Netherlands Antilles in 1972.

### 50 m rifle, prone

* Bèto Adriana
# T3 (Tram İzmir)

T3 Çiğli Tram (Turkish: T3 Çiğli Tramvayı) is a 12 km (7.5 mi) urban light rail transit (LRT) system in Çiğli district of İzmir, Turkey and is one of the three lines of Tram İzmir.

## History

Construction work on the tram line began in February 2021. Test drives began in December 2022 and the line entered service on 27 January 2024. The T3 Line is operated as two different ring lines, the Blue (Inner) Line following the "Ataşehir Kavşağı - İAOSB - Ataşehir Kavşağı" route and the Red (Outer) Line following the "Ataşehir Kavşağı - Kâtip Çelebi Üniversitesi - İAOSB - Ataşehir Kavşağı" route in the counterclockwise direction.

## Route

The Red (Outer) Line starts from Ataşehir Kavşağı and passes through Semra Aksu, Eski Havaalanı, Yenimahalle, Çiğli Bölge Hastanesi, Ata Sanayi and Evka 5 to reach Katip Çelebi Üniversitesi. The trams returning from Katip Çelebi Üniversitesi then pass through İAOSB Nedim Uysal Lisesi, Mustafa Kemal Atatürk Bulvarı, İAOSB Müdürlüğü, Kemal Baysak, Nihat Karakartal and Nazım Hikmet Ran and reach Ataşehir Kavşağı again to complete the ring service.
The Blue (Inner) Line starts from the Ataşehir Kavşağı, passes through Nazım Hikmet Ran, Nihat Karakartal, Kemal Baysak, İAOSB Müdürlüğü, Mustafa Kemal Atatürk Bulvarı and reaches İAOSB Nedim Uysal Lisesi. Unlike the Outer (Red) Line, it continues its route from the switch area without stopping at Katip Çelebi Üniversitesi and passes through Evka 5, Ata Sanayi, Çiğli Bölge Hastanesi, Yenimahalle, Eski Havaalanı and Semra Aksu, and reaches the Ataşehir Kavşağı again, completing the ring service.
It is possible to transfer from T3 line to T1 Tram line, İZBAN's Çiğli station and buses operated by ESHOT.
The tram line is operated by İzmir Metro. The line is served by tramcars produced by Hyundai Rotem plant in Adapazarı. The double-ended 32 m (105 ft)-long five-module tramcars are each 43.1 t heavy. They have 48 seating capacity, and can carry up to 285 passengers each. Service speed is 24 km/h (15 mph), and top speed is 70 km/h (43 mph). The tramcars run on standard track gauge at 1,435 mm (56.5 in). The electrification system of the tramcars is 750 V DC. The line has a communications-based train control (CBTC) signalling system.
# Sartell High School

Sartell High School is a public high school in Sartell, Minnesota, United States.
The original high school was constructed in 1969 and was the middle school prior to the 2020-2021 school year. It is now Riverview Intermediate School.
The old high school was constructed in 1993 and was remodeled to become the new Sartell Middle School. The new Sartell High School opened to the public fall of 2019.
It also includes a Student-Run Coffee Shop combined with the School Spirit Shop

## Demographics

The demographic breakdown of the 1,032 students enrolled for the 2012–2013 school year was:
* Male - 52.5%
* Female - 47.5%
* Asian/Pacific islander - 1.3%
* Black - 0.9%
* Hispanic - 1.3%
* White - 96.4%
* Multiracial - 0.1%
In addition, 13.2% of the students were eligible for free or reduced lunch.

## Athletics

Sartell's team name is the Sabres and their colors are royal blue and white. The following sports are offered:
* Baseball
* Basketball - Boys
* Basketball - Girls
* Cross Country
* Dance Team
* Football
* Golf - Boys
* Golf - Girls
* Gymnastics
* Hockey - Boys
* Hockey - Girls
* Knowledge Bowl
* Lacrosse - Boys
* Lacrosse - Girls
* Soccer - Boys
* Soccer - Girls
* Softball
* Swimming & Diving - Boys
* Swimming & Diving - Girls
* Tennis - Boys
* Tennis - Girls
* Track and Field - Boys and Girls
* Volleyball
* Wrestling

## Alumni

* Naarah Hastings (class of 1998), politician
* For All Those Sleeping (class of 2007), metalcore band
# Cohoes High School

Cohoes High School is a public high school located in Cohoes, Albany County, New York, U.S., and is the only high school operated by the Cohoes City School District.

## Notable alumni

* Theresa V. Brassard (class of 1947) – metallographer
* Aliann Pompey (class of 1995) – Olympic athlete

## Footnotes

* ↑ "Search for Public School Districts – District Detail for Cohoes City School District". National Center for Education Statistics. Institute of Education Sciences. Retrieved February 26, 2021.
* 1 2 3 "Search for Public Schools - Cohoes High School (360798000569)". National Center for Education Statistics. Institute of Education Sciences. Retrieved February 26, 2021.
* ↑ "COHOES HIGH SCHOOL". National Center for Education Statistics. Retrieved February 26, 2021.
* This New York (state) school–related article is a stub. You can help Wikipedia by expanding it.
* v
* t
* e
# 2013 in Ecuadorian football

The 2013 season is the 91st season of competitive football in Ecuador.

## Clubs in international competition

| Team | 2013 Copa Libertadores | 2013 Copa Sudamericana |
| Barcelona | Eliminated in the Second Stage | Enters in the First Stage |
| Emelec | Eliminated in the Round of 16 | Enters in the First Stage |
| Independiente José Terán | N/A | Enters in the First Stage |
| LDU Loja | N/A | Enters in the First Stage |
| LDU Quito | Eliminated in the First Stage | N/A |

### Barcelona
#### Copa Libertadores
##### Group 1

Second Stage: Group 1 :
| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts |
| 1 | Nacional | 6 | 3 | 1 | 2 | 10 | 6 | +4 | 10 |
| 2 | Boca Juniors | 6 | 3 | 0 | 3 | 7 | 7 | 0 | 9 |
| 3 | Toluca | 6 | 2 | 2 | 2 | 8 | 11 | −3 | 8 |
| 4 | Barcelona | 6 | 1 | 3 | 2 | 5 | 6 | −1 | 6 |

### Emelec
#### Copa Libertadores
##### Group 4

Second Stage: Group 4 :
| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts |
| 1 | Vélez Sarsfield | 6 | 4 | 1 | 1 | 10 | 3 | +7 | 13 |
| 2 | Emelec | 6 | 3 | 1 | 2 | 5 | 4 | +1 | 10 |
| 3 | Peñarol | 6 | 3 | 0 | 3 | 7 | 7 | 0 | 9 |
| 4 | Iquique | 6 | 1 | 0 | 5 | 5 | 13 | −8 | 3 |

##### Round of 16: Match F
### LDU Quito
#### Copa Libertadores
##### First stage
## National teams
### Senior team
#### 2014 FIFA World Cup qualification

| Pos | Teamvte | Pld | W | D | L | GF | GA | GD | Pts | Qualification |
| 1 | Argentina | 16 | 9 | 5 | 2 | 35 | 15 | +20 | 32 | 2014 FIFA World Cup |
| 2 | Colombia | 16 | 9 | 3 | 4 | 27 | 13 | +14 | 30 | 2014 FIFA World Cup |
| 3 | Chile | 16 | 9 | 1 | 6 | 29 | 25 | +4 | 28 | 2014 FIFA World Cup |
| 4 | Ecuador | 16 | 7 | 4 | 5 | 20 | 16 | +4 | 25 | 2014 FIFA World Cup |
| 5 | Uruguay | 16 | 7 | 4 | 5 | 25 | 25 | 0 | 25 | Inter-confederation play-offs |
| 6 | Venezuela | 16 | 5 | 5 | 6 | 14 | 20 | −6 | 20 | |
| 7 | Peru | 16 | 4 | 3 | 9 | 17 | 26 | −9 | 15 | |
| 8 | Bolivia | 16 | 2 | 6 | 8 | 17 | 30 | −13 | 12 | |
| 9 | Paraguay | 16 | 3 | 3 | 10 | 17 | 31 | −14 | 12 | |

#### Friendlies
### U-20 team
#### South American Youth Championship

Group B :
| Teamvte | Pld | W | D | L | GF | GA | GD | Pts |
| Peru | 4 | 2 | 1 | 1 | 7 | 5 | +2 | 7 |
| Uruguay | 4 | 1 | 3 | 0 | 10 | 9 | +1 | 6 |
| Ecuador | 4 | 1 | 2 | 1 | 5 | 5 | 0 | 5 |
| Venezuela | 4 | 1 | 1 | 2 | 3 | 4 | −1 | 4 |
| Brazil | 4 | 1 | 1 | 2 | 4 | 6 | −2 | 4 |
Final stage :
| Teamvte | Pld | W | D | L | GF | GA | GD | Pts |
| Colombia | 5 | 4 | 0 | 1 | 6 | 3 | +3 | 12 |
| Paraguay | 5 | 3 | 1 | 1 | 7 | 4 | +3 | 10 |
| Uruguay | 5 | 3 | 0 | 2 | 5 | 3 | +2 | 9 |
| Chile | 5 | 2 | 1 | 2 | 7 | 6 | +1 | 7 |
| Peru | 5 | 1 | 2 | 2 | 6 | 8 | −2 | 5 |
| Ecuador | 5 | 0 | 0 | 5 | 4 | 11 | −7 | 0 |
# 1908 National Education Association Spelling Bee

The 1908 National Education Association Spelling Bee was a team-based, inter-city spelling bee held on June 29, 1908, at the Hippodrome Theater in Cleveland, Ohio. Predating the 1st Scripps National Spelling Bee in 1925 by seventeen years, this 1908 competition was the first national spelling bee in the United States. Cleveland won the team competition, and Marie C. Bolden was the individual champion.

## Competition

The spelling bee was part of the forty-sixth annual convention of the National Education Association (NEA), which was held in Cleveland. The NEA invited teams to compete from across the United States and promoted the competition as the first national spelling bee. Six thousand people, including convention speaker Booker T. Washington, attended the event at the Hippodrome.
Unlike the later Scripps National Spelling Bee competitions, the 1908 NEA Spelling Bee was an inter-city contest, with teams of fifteen eighth-graders each participating from Cleveland, Erie, Pennsylvania, Pittsburgh, and New Orleans. For the competition, each student took a written spelling test of one hundred words, and then spelled four words aloud on stage. The total number of spelling mistakes in both the written and verbal competitions determined the winning team.
The Cleveland team won the competition with the fewest errors, followed by Pittsburgh in second place, New Orleans in third place, and Erie, Pennsylvania in fourth. Marie C. Bolden, a thirteen-year-old black girl whose father was a mail carrier, was the only Cleveland speller with no errors, so she was named the individual champion and received a gold medal.

## Controversy

Even before the competition, some members of the all-white New Orleans team "...balked at the idea of spelling against a negro girl..." in a racially integrated team such as Cleveland's. After Marie Bolden and the Cleveland team won the competition, New Orleans school superintendent Warren Easton apologized to the people of New Orleans, promised that New Orleans students would not participate in any other contests in Northern states, and was censured by the New Orleans school board for allowing white students to compete against a black speller.
Also in New Orleans, after Marie Bolden's victory, the local black YMCA organized a spelling bee to be held in her honor. However, under pressure from mayor Martin Behrman due to high tensions "over race questions", the event was canceled.
In the written portion of the competition, pronouncer Solomon Henry Clark gave an incorrect example for the word "capitol", causing many spellers to write it as "capital". After the second-place Pittsburgh team and others raised concerns, the spelling bee organizers re-scored the written tests. After re-scoring, the teams kept their overall rankings, but Marie Bolden no longer had a perfect score, and two other girls on the Cleveland team did. Marie Bolden was still allowed to keep her gold medal and title as champion.
# The Imp

The Imp may refer to:
* The Imp (A Song of Ice and Fire), nickname of Tyrion Lannister, a character from the A Song of Ice and Fire series by George R. R. Martin
* The Imp (Little Nemo in Slumberland), a character in the comic strip Little Nemo in Slumberland by Winsor McCay
* The Imp (zine), a comics zine published by Daniel K. Raeburn during the late 1990s early 2000s
* The Imp (1919 film), a 1919 American crime drama film directed by Robert Ellis
* The Imp (1981 film), a 1981 Hong Kong film directed by Dennis Yu
* The Imp (1996 film), a 1996 Hong Kong film directed by Kai Ming Lai
* The Imp (television series), a short animation series created by Andy Fielding
* The Imp (fantasy football manager), a losing fantasy football manager in the FIVER league, played by Gunnar Örn Ingólfsson
* Imp Mountain, New Hampshire, United States
# Guyana at the 1972 Summer Olympics

Guyana competed at the 1972 Summer Olympics in Munich, West Germany. Three competitors, all men, took part in four events in two sports.

## Boxing

Men's Light Middleweight (– 71 kg)
* Reginald Ford
   * First Round – Bye
   * Second Round – Lost to Alan Minter (GBR), KO-2

## Cycling

One cyclist represented Guyana in 1972.

### Sprint

* Neville Hunte

### 1000m time trial

* Neville Hunte
   * Final – 1:10.48 (→ 22nd place)
# Saverton School

Saverton School, also known as Saverton Community Center , is a historic school building located at Saverton, Ralls County, Missouri. It was built in 1934, and is a one-story hipped roof, frame building with two school rooms. It measures 52 feet by 24 feet, with a 52 feet by 13 feet addition constructed in 1960. The building has housed a community centre since 1959.$^{:5}$
It was listed on the National Register of Historic Places in 1998.
# Armentano

Armentano is an Italian surname. Notable people with the surname include:
* Amedeo Rocco Armentano (1886–1966), Italian esotericist
* Anthony J. Armentano (1916–1987), American politician
* Mariano Armentano (born 1974), Argentine soccer player
* Paul Armentano, American cannabis activist
* Ricardo Armentano (born 1957), Uruguayan professor and researcher
# First National Bank Building (Gastonia, North Carolina)

First National Bank Building, also known as the Lawyers Building, is a historic office building located at Gastonia, Gaston County, North Carolina. It was designed by Wilson & Sompayrac and built in 1916–1917. It is a seven-story, rectangular, Classical Revival-style steel frame building. It is sheathed in cream-colored brick with limestone and terra cotta trim.
It was listed on the National Register of Historic Places in 1986. It is located in the Downtown Gastonia Historic District.
# Kanamechō Station

Kanamecho Station (要町駅, Kanamechō-eki) is a subway station in Toshima, Tokyo, Japan, operated by the Tokyo subway operator Tokyo Metro.

## Lines

Kanamechō Station is served by the Tokyo Metro Yurakucho Line (station number "Y-08") and the Tokyo Metro Fukutoshin Line (station number "F-08").

## Station layout

The station consists of two island platforms on different levels. The Yurakucho Line platform (tracks 1 and 2) is located on the second basement ("B2F") level, while the Fukutoshin Line platform (tracks 3 and 4) is located on the third basement ("B3F") level. The platforms are equipped with waist-height platform edge doors.

### Platforms

| 1 | Y Yūrakuchō Line | for Ikebukuro, Yūrakuchō, and Shin-Kiba |
| 2 | Y Yūrakuchō Line | for Wakōshi TJ Tobu Tojo Line for Shiki, Kawagoeshi, and Shinrinkōen |
| 3 | F Fukutoshin Line | for Ikebukuro, Shinjuku-sanchōme, and Shibuya TY Tōyoko Line for Yokohama Minatomirai Line for Motomachi-Chukagai Sōtetsu Izumino Line for Shōnandai via SH Shin-yokohama Line |
| 4 | F Fukutoshin Line | for Wakōshi TJ Tobu Tojo Line for Shiki, Kawagoeshi, and Shinrinkōen |
* Yurakucho Line platform
* Fukutoshin Line platform

## History

The station opened on 24 June 1983, serving the Tokyo Metro Yurakucho Line. The Tokyo Metro Fukutoshin Line also started operating through this station on 14 June 2008.
The station facilities were inherited by Tokyo Metro after the privatization of the Teito Rapid Transit Authority (TRTA) in 2004.
Waist-height platform edge doors were installed in January 2011.
# Musashi-Shiraishi Station

Musashi-Shiraishi Station (武蔵白石駅, Musashi-Shiraishi-eki) is a passenger railway station located in Kawasaki-ku, Kawasaki, Kanagawa Prefecture, Japan, operated by East Japan Railway Company (JR East).

## Lines

Musashi-Shiraishi Station is served by the Tsurumi Line, and is 4.1 kilometers (2.5 mi) from the terminus of the line at Tsurumi Station. The station is located at the junction of the main route of the Tsurumi Line and its branch to Ōkawa, however the platform for the branch line at the station was removed in March 1996 so that only mainline trains now stop at the station.

## Station layout

The station consists of two opposed side platforms serving two tracks, connected by a level crossing. The station is unattended.

### Platforms

| 1 | JI Tsurumi Line | for Hama-Kawasaki and Ōgimachi |
| 2 | JI Tsurumi Line | for Asano, Bentembashi, and Tsurumi |

## History

Musashi-Shiraishi Station was opened on 10 March 1926 as a station on the privately held Tsurumi Rinkō Railway (鶴見臨港鉄道, Tsurumi Rinkō Tetsudō) initially for freight operations only. The station was closed on November 15, 1930 and reopened as the Musashi-Shiraishi Stop for passenger services only from 26 July 1931. It was elevated in status to that of a full station on 17 March 1936. The line was nationalized on 1 July 1943 and was absorbed into the Japanese Government Railways network. The station has been unstaffed since 1 March 1971. Upon the privatization of the Japanese National Railways (JNR) on 1 April 1987 the station has been operated by JR East.
The short platform (platforms 3 and 4) for the Ōkawa branch line was used until March 1996, when the branch line started operating three-car trains that were longer than the platform.

## Passenger statistics

In fiscal 2008, the station was used by an average of 1,601 passengers daily (boarding passengers only).

## Surrounding area

* Fuji Electric Kawasaki Factory
# Subida a Urkiola

Subida a Urkiola is a one-day cycling race in Durango, Biscay in the Basque Country whose starts in Durango and ends at the Sanctuary of Urkiola. The first edition began in 1931, organized by the Sociedad Ciclista Bilbaina. It has not been held consistently since 1984. Since 2005, the race has been organized as a 1.1 event on the UCI Europe Tour.

## Winners

| Year | Country | Rider | Team |
| 1931 | Spain | Ricardo Montero | |
| 1932- 1935 | No race | No race | No race |
| 1936 | Italy | Claudio Leturia | |
| 1936- 1960 | No race | No race | No race |
| 1961 | Spain | Antonio Karmany | |
| 1962 | Spain | Julio Jiménez | |
| 1963 | No race | No race | No race |
| 1964 | Spain | Julio Jiménez | |
| 1965 | Spain | Julio Jiménez | |
| 1966 | Spain | Eusebio Velez | |
| 1967 | No race | No race | No race |
| 1968 | No race | No race | No race |
| 1969 | Spain | Gabriel Mariscal | |
| 1970- 1983 | No race | No race | No race |
| 1984 | Spain | Vicente Belda | |
| 1985 | Spain | José Rodriguez Magro | |
| 1986 | Colombia | Óscar Vargas | |
| 1987 | Spain | Marino Lejarreta | |
| 1988 | Spain | Marino Lejarreta | |
| 1989 | United States | Andrew Hampsten | |
| 1990 | United States | Andrew Hampsten | |
| 1991 | Spain | Pedro Delgado | |
| 1992 | Italy | Claudio Chiappucci | |
| 1993 | Switzerland | Tony Rominger | |
| 1994 | Spain | José María Jiménez | |
| 1995 | Italy | Leonardo Piepoli | |
| 1996 | Spain | José María Jiménez | |
| 1997 | Switzerland | Beat Zberg | |
| 1998 | Italy | Simone Bhorgheresi | |
| 1999 | Italy | Leonardo Piepoli | |
| 2000 | Italy | Francesco Casagrande | |
| 2001 | Spain | Jon Odriozola | |
| 2002 | Italy | Dario Frigo | |
| 2003 | Italy | Leonardo Piepoli | |
| 2004 | Italy | Leonardo Piepoli | |
| 2005 | Spain | Joaquim Rodríguez | |
| 2006 | Spain | Iban Mayo | |
| 2007 | Spain | José Ángel Gómez Marchante | |
| 2008 | Spain | David Arroyo | |
| 2009 | Spain | Igor Antón | |
# Otilonium bromide

Otilonium bromide is a drug used to treat abdominal pain caused by irritable bowel syndrome. It is an antispasmodic, which is useful to treat the symptoms of irritable bowel syndrome by reducing abdominal spasms (colic), bloating, pain, and gut motility.
It is an antimuscarinic and calcium channel blocker used to relieve spasmodic pain of the gut, especially in irritable bowel syndrome. This means it works in the gut themselves, by relaxing the small muscles of the intestines, which results in relieving cramps and therefore reduces pain.

## Medical uses

A pooled analysis of three clinical trials suggest that otilonium bromide is more effective than placebo for the treatment of irritable bowel syndrome.

## Pharmacology

Otilonium bromide binds to both muscarinic receptors and tachykinin NK$_2$ receptors. It has been shown to inhibit L-type and T-type calcium channels, actions which may contribute to or determine its effects in the gut.
When taken orally, very little of the drug is absorbed into the rest of the body, which means that most of its actions remain confined to the gastrointestinal system.

## Adverse effects

Otilonium bromide is generally well tolerated and does not have the side-effects observed with similar classes of drugs. A case of cardiovascular toxicity was reported due to an overdose.