# U.S. Route 68

U.S. Route 68 (US 68) is a United States highway that runs for 560 miles (900 km) from northwest Ohio to Western Kentucky. The highway's western terminus is at US 62 in Reidland, Kentucky. Its present eastern terminus is at Interstate 75 in Findlay, Ohio, though the route once extended as far north as Toledo. US 68 intersects with US 62 three times during its route.

## Route description

US 68 is signed east–west in Kentucky, while in Ohio it is signed north–south.

### Kentucky

U.S. Route 68 is designated as a "Scenic Highway" throughout Kentucky. US 68 passes near or through Reidland, Aurora, Cadiz, Hopkinsville, Elkton, Russellville, Auburn, Bowling Green, Glasgow, Edmonton, Greensburg, Campbellsville, Lebanon, Perryville, Harrodsburg, Lexington, Paris, and Maysville.
The majority of the route winds through forested, hilly terrain. US 68 is Broadway through downtown Lexington, and it is Harrodsburg Road before it leaves Lexington.
The route passes several Civil War battle sites. The Jefferson Davis State Historic Site is located along the highway, approximately 9 miles (14 km) east of Hopkinsville at the small town of Fairview. The Battle of Tebbs Bend Historic Civil War Site is located near Campbellsville and the Perryville Battlefield State Historic Site is outside Perryville.
There is an annual 400-mile (640 km) yard sale, held along the highway for four days in early summer.
The sections of the highway through Campbellsville and Lebanon are slated for expansion to begin in 2008. The long-term goal is to widen and make safer the entire US 68 corridor through Kentucky as part of the Heartland Parkway project.
Sections in Kentucky have been improved in recent years. The Paris Pike was completed in 2003. Work is currently in progress to make US 68 four lanes through Land Between the Lakes. This was accelerated, following a devastating collision of the cargo vessel MV Delta Mariner with Eggner Ferry Bridge in January 2012.

### Ohio

US 68 takes a south–north route throughout Ohio, roughly paralleling Interstate 75 but covering counties one tier to the east of those counties covered by I-75. US 68 begins at the William H. Harsha Bridge over the Ohio River and is immediately concurrent with US 52 and US 62 for 5.6 miles (9.0 km) while traveling on the north bank of the river. US 52 leaves the concurrency at Ripley, at which point US 68 and US 62 head north for 5.3 miles (8.5 km) as a generally rural two-lane highway. In Brown County's Jefferson Township, near Redoak, US 62 leaves the concurrency. Afterward, US 68 passes through or bypasses communities such as Georgetown, Mount Orab, Fayetteville, Wilmington, Xenia, and Yellow Springs. Shortly before reaching Interstate 70, it becomes a four-lane expressway, bypassing Springfield before transitioning back to a rural two-lane road as it approaches Urbana. As it continues north, US 68 passes through West Liberty, Bellefontaine, Kenton, Dunkirk, and Arlington on its way north to its terminus at an interchange with Interstate 75 outside Findlay.
Near Redoak in Brown County, the designation "Brigadier General Charles Young Memorial Historical Corridor" leaves the US 62/US 68 concurrency and joins US 68 solely at the routes' junction. The designation is in honor of Young, a pioneering figure in US history, and at his death, the highest-ranking Black officer in the Regular Army. The memorial historical corridor stretches northward to Xenia, where it leaves US 68 and joins US 42 at the junction of those routes.
In total, US 68 traverses 179.1 miles within Ohio.

## History
### Original route in central Kentucky

From 1926 until the late 1940s, in terms of the routing between Bowling Green and Perryville, US 68's concurrency with US 31W went further northeast through southeastern Edmonson and northwestern Barren counties to Horse Cave, in Hart County. US 68 then followed the present-day Kentucky Route 218 (Charlie Moran Highway) to the US 31E junction at Wigwam, and then joined US 31E northward through LaRue and Nelson counties to Bardstown, where it joined US 150 for a concurrency that lasted through Washington County until it went solo in Perryville. US 68 moved to its current routing between Bowling Green and Perryville (except for the later rerouting onto Glasgow's Veterans Outer Loop) around 1948–49.

### Original alignment in northwestern Ohio

US 68 previously ran to Toledo, Ohio, terminating at the west approach to the Anthony Wayne Bridge south of downtown, but the Toledo-Findlay segment was decommissioned in the 1950s. It also passed through Springfield, Ohio prior to its realignment onto a four-lane bypass of that city.

### Widening project in western Kentucky (1990s)

For much of the 1990s, much of the US 68/KY 80 corridor from the I-24 junction near Cadiz to the Natcher Parkway (now I-165) junction in Bowling Green was under construction for a regional construction project to widen the corridor to four lanes, with several alignments remaining intact, especially around small towns such as Fairview and Auburn. The project included bypass routes in Hopkinsville and Russellville.

### Eggner Ferry Bridge incident (2012)

Two spans of the US 68/KY 80 Eggner Ferry Bridge over Kentucky Lake collapsed after being struck by a cargo ship on January 26, 2012. The bridge reopened to traffic on May 25, 2012. That bridge was replaced by a new four-lane bridge a few years afterwards.

### Ohio roundabout

In summer 2020, ODOT made plans to convert the intersection with SR 235, the state route's southern terminus, to a roundabout, near Oldtown in Xenia Township, Greene County, Ohio, almost four miles (6.4 km) north of downtown Xenia. Construction was expected to begin in spring 2023 and to be completed that fall, with an estimated cost of $2 million. However, site preparations did not begin until early June 2024, and it was announced that construction would begin on July 16, at a cost of $2.29 million, to be completed by the fall. On December 3, 2024, the roundabout was substantially completed except for minor finish work such as landscaping, which is scheduled to be done in spring 2025.

## Future

In Springfield Township, Clark County, Ohio, there is an almost full-access interchange between controlled-access US 68 and US 40/SR 4, which is itself a controlled-access highway until approximately 0.3-mile west of the US 68 interchange. One exit ramp from US 68 ends on Upper Valley Pike, rather than on US 40/SR 4; another entrance ramp includes two-way traffic and an at-grade entrance to a retirement community. On US 40/SR 4 between the controlled-access portion and US 68, there are an at-grade intersection at Upper Valley Pike, other street and driveway breaks in access control and a steep grade on the eastbound approach toward Upper Valley Pike. In September 2013, the Clark County-Springfield Transportation Coordinating Committee (TCC) ranked the US 40/SR 4/Upper Valley Pike intersection as the most hazardous in the county, based on 2010-2012 crash data. Because the road design over the years had played a significant factor in the high number of crashes in the area, the TCC conducted a study; in February 2006 it recommended reconfiguring the US 68 interchange and altering nearby traffic patterns. The Ohio Department of Transportation (ODOT) the same year approved $5 million to fund the project. However, the TCC soon rejected ODOT's money, concluding that even its recommended fix would not be enough to solve the area road network's underlying problems. Instead, the TCC is making small changes, such as improving traffic signal timing and adding signs. ODOT, for its part, is working on reducing the number of driveways near the US 40/SR 4/Upper Valley Pike intersection and on upgrading traffic signals.
On December 7, 2023, ODOT announced that it would provide a $2.6 million grant to construct a single-lane roundabout at Fairfield Pike in Springfield Township, Clark County, Ohio, on the border with Springfield, in 2028.

## Major intersections

| State | County | Location | mi | km | Destinations | Notes |
| Kentucky | McCracken | Reidland | 0.000 | 0.000 | US 62 – Paducah, Kentucky Dam | Western terminus |
| Kentucky | McCracken | ​ | 0.882– 1.095 | 1.419– 1.762 | I-24 – St. Louis, Nashville | I-24 Exit 16 |
| Kentucky | McCracken | ​ | 1.342 | 2.160 | KY 284 west (Benton Road) – Reidland, Symsonia | Eastern terminus of KY 284 |
| Kentucky | McCracken | ​ | 2.177 | 3.504 | KY 787 (Rosebower Church Road) | |
| Kentucky | Marshall | Sharpe | 3.841 | 6.181 | KY 1042 north (Sharpe School Road) / Sharpe-Elva Road | Southern terminus of KY 1042 |
| Kentucky | Marshall | Sharpe | 4.273 | 6.877 | KY 795 south (Scale Road) | Western end of KY 795 concurrency |
| Kentucky | Marshall | Sharpe | 4.357 | 7.012 | KY 795 north (Scale Road) / Brien Cutoff Road | Eastern end of KY 795 concurrency |
| Kentucky | Marshall | ​ | 6.005 | 9.664 | KY 1610 north (Mt. Moriah Road) | Southern terminus of KY 1610 |
| Kentucky | Marshall | ​ | 6.502 | 10.464 | KY 1396 south (Georgia Clark Road South) | Northern terminus of KY 1396 |
| Kentucky | Marshall | ​ | 7.613 | 12.252 | KY 1712 south (Griggstown Road) | Northern terminus of KY 1712 |
| Kentucky | Marshall | ​ | 7.842 | 12.620 | KY 1413 north (Patterson Ferry Road) | Southern terminus of KY 1413 |
| Kentucky | Marshall | Palma | 9.152 | 14.729 | KY 3456 north (Needmore Road) | Southern terminus of KY 3456 |
| Kentucky | Marshall | ​ | 9.563 | 15.390 | KY 1422 east (Palma Road) | Western terminus of KY 1422 |
| Kentucky | Marshall | ​ | 10.462 | 16.837 | KY 95 north | Southern terminus of KY 95 |
| Kentucky | Marshall | ​ | 11.413 | 18.367 | KY 782 west | Eastern terminus of KY 782 |
| Kentucky | Marshall | ​ | 12.061– 12.163 | 19.410– 19.574 | I-69 – Mayfield, Calvert City | I-69 (Former Pennyrile Parkway) exit 47 |
| Kentucky | Marshall | Draffenville | 12.339 | 19.858 | US 641 north – Land Between the Lakes Northern Entrance, Kentucky Dam Village State Resort Park | Western end of US 641 concurrency |
| Kentucky | Marshall | Draffenville | 12.755 | 20.527 | US 641 south – Benton, Murray | Eastern end of US 641 concurrency; provides access to Marshall County Hospital in Benton |
| Kentucky | Marshall | Briensburg | 14.509 | 23.350 | KY 58 west (Briensburg Road) | Eastern terminus of KY 58 |
| Kentucky | Marshall | ​ | 16.115 | 25.935 | Moors Camp Highway | Former KY 963 |
| Kentucky | Marshall | ​ | 16.627 | 26.759 | KY 1462 west (Benton-Birmingham Road) | Eastern terminus of KY 1462 |
| Kentucky | Marshall | ​ | 16.677 | 26.839 | Big Bear Highway | Former KY 68 east |
| Kentucky | Marshall | ​ | 19.420 | 31.253 | KY 408 west (Eggners Ferry Road) | Eastern terminus of KY 408 |
| Kentucky | Marshall | ​ | 20.644 | 33.223 | Barge Island Road – Girl Scout Camp, Camp Kum-Ba-Ya, Camp Currie | Former KY 962 north |
| Kentucky | Marshall | Fairdealing | 20.681 | 33.283 | KY 962 south (Old Olive Road) | Northern terminus of KY 962 |
| Kentucky | Marshall | ​ | 21.469 | 34.551 | KY 1364 south (Olive Creek Road) | Northern terminus of KY 1364 |
| Kentucky | Marshall | ​ | 21.917 | 35.272 | KY 1484 north | Southern terminus of KY 1484 |
| Kentucky | Marshall | Aurora | 28.490 | 45.850 | KY 402 west (Aurora Highway) – Mayfield | Eastern terminus of KY 402 |
| Kentucky | Marshall | Aurora | 29.910 | 48.135 | KY 80 west / Bayview Road – Kenlake Lodge and Marina, Murray | Western end of KY 80 concurrency |
| Kentucky | Kentucky Lake | Kentucky Lake | 30.118– 31.183 | 48.470– 50.184 | Eggner's Ferry Bridge | Eggner's Ferry Bridge |
| Kentucky | Trigg | Land Between the Lakes | 33.372 | 53.707 | The Trace – Grand Rivers, KY, Dover, TN | Interchange |
| Kentucky | Trigg | ​ | 39.491– 39.851 | 63.555– 64.134 | Lake Barkley Bridge | Lake Barkley Bridge |
| Kentucky | Trigg | Canton | 40.507 | 65.190 | KY 164 south (Linton Road) – Devil's Hill launching ramp, Calhoun Hill launching ramp | Northern terminus of KY 164 |
| Kentucky | Trigg | ​ | 40.507 | 65.190 | KY 1489 east (State Park Road) | Western terminus of KY 1489; Lake Barkley State Park Airport near eastern end of 1489 |
| Kentucky | Trigg | ​ | 43.213 | 69.545 | KY 3568 east (Canton Road) | Western terminus of KY 3568; former alignment of US 68 |
| Kentucky | Trigg | ​ | 45.578 | 73.351 | KY 272 east (Old Canton Road) to KY 1062 south (Maple Grove Road) | Western terminus of KY 272 |
| Kentucky | Trigg | ​ | 46.016 | 74.056 | KY 1489 west (Blue Spring Road) – Lake Barkley State Resort Park | Eastern terminus of KY 1489; access to Lake Barkley State Park Airport |
| Kentucky | Trigg | ​ | 46.885 | 75.454 | KY 3568 west (Old Canton Road) | Eastern terminus of KY 3568; former alignment of US 68 |
| Kentucky | Trigg | ​ | 47.128 | 75.845 | US 68 Bus. east (Canton Road) – Cadiz | Western terminus of Cadiz business route |
| Kentucky | Trigg | ​ | 47.614 | 76.627 | KY 1175 (Old Dover Road) – Cadiz | |
| Kentucky | Trigg | ​ | 49.129 | 79.065 | KY 139 (South Road) – Cadiz | |
| Kentucky | Trigg | Cadiz | 51.499 | 82.880 | US 68 Bus. west (Main Street) – Cadiz Business District | Eastern end of Cadiz business route; access to Trigg County Hospital |
| Kentucky | Trigg | Cadiz | 51.719 | 83.234 | KY 3468 east (Hopkinsville Road) | Western terminus of KY 3468; former alignment of US 68 |
| Kentucky | Trigg | Cadiz | 54.509 | 87.724 | KY 3468 west (Hopkinsville Road) | Eastern terminus of KY 3468 |
| Kentucky | Trigg | Cadiz | 54.744 | 88.102 | KY 1585 south (North Montgomery Road) / KY 276 west (Rocky Ridge Road) | Northern terminus of KY 1585;eastern terminus of KY 276 |
| Kentucky | Trigg | ​ | 55.083– 55.217 | 88.647– 88.863 | I-24 – Nashville, Paducah | I-24 exit 65 |
| Kentucky | Trigg | ​ | 55.779 | 89.768 | KY 958 north (Barefield Road) | Southern terminus of KY 958 |
| Kentucky | Trigg | ​ | 58.529 | 94.193 | KY 128 north (Wallonia Road) – Cerulean | Southern terminus of KY 128 |
| Kentucky | Trigg | ​ | 58.766 | 94.575 | KY 3186 east (Tobacco Road) – Gracey | Western terminus of KY 3186 |
| Kentucky | Christian | Gracey | 59.610 | 95.933 | KY 1026 (Gracey-Sinking Spring Road) | |
| Kentucky | Christian | ​ | 60.271 | 96.997 | KY 3186 west (Lester Road) – Gracey | Eastern terminus of KY 3186 |
| Kentucky | Christian | ​ | 61.823 | 99.494 | KY 1349 north (Quisenberry Lane) | Southern terminus of KY 1349 |
| Kentucky | Christian | Hopkinsville | 66.008 | 106.230 | US 68 Byp. east / US 68 Truck east / KY 1682 east (Eagle Way) to Pennyrile Parkway | Western terminus of Hopkinsville bypass/truck routes and KY 1682 1682 to the north, 68 Bypass/truck to the south; parkway via 1682, hospital via 68 Bypass |
| Kentucky | Christian | Hopkinsville | 67.981 | 109.405 | KY 91 north (Princeton Road) – Princeton, Fredonia | Southern terminus of KY 91 |
| Kentucky | Christian | Hopkinsville | 68.293 | 109.907 | KY 109 north (Dawson Springs Road) – Pennyrile Forest State Park | Western end of KY 109 concurrency |
| Kentucky | Christian | Hopkinsville | 69.008 | 111.058 | KY 1007 (North Drive) – Community College, MSU Breathitt Veterinary Center | |
| Kentucky | Christian | Hopkinsville | 69.737 | 112.231 | US 41 south / KY 107 south (South Main Street) | Western end of US 41 concurrency; southern terminus of one-way south section of US 41; 107 to the south, 41 comes in from the north |
| Kentucky | Christian | Hopkinsville | 69.801 | 112.334 | US 41 north / KY 107 north (South Virginia Street) | West end of KY 107 overlap; 107 enters from the south; 41 north to the north, 41 south continues concurrent with 68 |
| Kentucky | Christian | Hopkinsville | 69.860 | 112.429 | KY 2544 south (South Liberty Street) | Southern terminus of one-way section of KY 2544; former alignment of US 41 south |
| Kentucky | Christian | Hopkinsville | 69.920 | 112.525 | KY 2544 north (South Clay Street) | Southern terminus of KY 2544; former alignment of US 41 south |
| Kentucky | Christian | Hopkinsville | 70.040 | 112.718 | KY 107 north (South Campbell Street) | Eastern end of KY 107 concurrency |
| Kentucky | Christian | Hopkinsville | 70.125 | 112.855 | US 41 Alt. south (South Walnut Street) | Northern terminus of KY/TN US 41 Alternate route |
| Kentucky | Christian | Hopkinsville | 70.330 | 113.185 | US 41 south / KY 109 south (East 9th Street) – Pembroke | Eastern end of US 41/KY 109 concurrency |
| Kentucky | Christian | Hopkinsville | 70.634– 70.786 | 113.674– 113.919 | Pennyrile Parkway to I-69 – Ft. Campbell, Madisonville | Pennyrile Parkway exit 9; future I-169 |
| Kentucky | Christian | Hopkinsville | 71.585 | 115.205 | KY 1979 west (East 7th Street) | Eastern terminus of KY 1979 |
| Kentucky | Christian | Hopkinsville | 71.647 | 115.305 | Airport Road – Hopkinsville-Christian County Airport | |
| Kentucky | Christian | Hopkinsville | 73.520 | 118.319 | US 68 Byp. west (Dr Martin Luther King Jr Way) | Eastern terminus of Hopkinsville bypass route |
| Kentucky | Christian | ​ | 75.052 | 120.784 | KY 1716 north (Overby Lane) | Southern terminus of KY 1716 |
| Kentucky | Christian | ​ | 77.744 | 125.117 | KY 1027 west (Rosetown Road) | Eastern terminus of KY 1027 |
| Kentucky | Christian | ​ | 79.142 | 127.367 | US 68 Alt. east (Jefferson Davis Road) – Fairview | Western terminus of US 68 alternate route |
| Kentucky | Christian | ​ | 79.884 | 128.561 | KY 1843 (Vaughns Grove-Fairview Road) – Fairview | |
| Kentucky | Christian | ​ | 80.436 | 129.449 | Britmart Road – Jefferson Davis Monument State Historic Site | Former KY 1081 |
| Kentucky | Todd | ​ | 81.201 | 130.680 | US 68 Alt. west (Jefferson Davis Road) – Fairview | Eastern terminus of US 68 alternate route |
| Kentucky | Todd | Tress Shop | 85.228 | 137.161 | KY 475 south (Tress Shop Road) | Northern terminus of KY 475 |
| Kentucky | Todd | Elkton | 86.470 | 139.160 | US 68 Bus. east / North David Hightower – Elkton | Western terminus of Elkton business route |
| Kentucky | Todd | Elkton | 89.234 | 143.608 | KY 181 (Greenville Road) – Elkton Historic District, Birthplace of Robert Penn Warren, Lake Malone State Park, Elkton Guthrie Airport | Lake Malone to the north, everything else to the south |
| Kentucky | Todd | Elkton | 91.419 | 147.125 | US 68 Bus. east / Williams Hill Road – Elkton | Eastern terminus of Elkton business route |
| Kentucky | Todd | ​ | 94.433 | 151.975 | KY 1309 east (Old Volney Road) – Daysville | Western terminus of KY 1309 |
| Kentucky | Logan | Whippoorwill | 97.884 | 157.529 | KY 1151 (Union Church Road) | |
| Kentucky | Logan | Russellville | 103.323 | 166.282 | US 68 Bus. east (Hopkinsville Road) / US 431 south – Adairsville, Clarksville, TN | Western terminus of Russellville business route; eastern end of US 431 concurrency |
| Kentucky | Logan | Russellville | 103.806 | 167.060 | KY 178 (Highland Lick Road) | |
| Kentucky | Logan | Russellville | 104.814 | 168.682 | US 431 north / Terry Wilcut Highway – Lewisburg, Central City, Boy Scout Camp, Lake Malone State Park | Eastern end of US 431 concurrency |
| Kentucky | Logan | Russellville | 105.197 | 169.298 | KY 3519 (North Main Street / Lewisburg Road) | |
| Kentucky | Logan | ​ | 107.304 | 172.689 | KY 79 (Peyton Street / Morgantown Road) | |
| Kentucky | Logan | Russellville | 109.031 | 175.468 | US 68 Bus. west (Bowling Green Road) / US 79 south (Russellville Bypass) – Franklin, Adairsville, Clarksville | Eastern end of Russellville business route; northern terminus of US 79; Russellville-Logan County Airport to the south via 79 |
| Kentucky | Logan | ​ | 113.290 | 182.323 | KY 2369 south (Dennis-Corinth Road) / Stevenson Mill Road | Northern terminus of KY 2369 |
| Kentucky | Logan | ​ | 115.717 | 186.228 | KY 722 west (Duncans Chapel Road) | Eastern terminus of KY 722 |
| Kentucky | Logan | Auburn | 116.508 | 187.501 | US 68 Bus. east (West Main Street) / Matlock Lane – Auburn Business District | Western terminus of Auburn business route |
| Kentucky | Logan | Auburn | 118.173 | 190.181 | KY 103 – Auburn Elementary School, Chandlers Chapel | |
| Kentucky | Logan | Auburn | 119.513 | 192.338 | US 68 Bus. west (East Main street) – Auburn Business District | Eastern end of Auburn business route |
| Kentucky | Logan | ​ | 121.445 | 195.447 | KY 73 (South Union Road / Cave Springs Road) – 1869 Shaker Tavern, Historic Franklin | Michigan left intersection |
| Kentucky | Logan | ​ | 122.694 | 197.457 | KY 1466 (Shakertown Road) – South Union Shaker Village | |
| Kentucky | Logan | ​ | 124.105 | 199.728 | KY 2349 south (Stamps Road) | Northern terminus of KY 2349; road continues as Stamps Road north of intersection |
| Kentucky | Warren | ​ | 124.478 | 200.328 | KY 240 east (Petros Road) | Western terminus of KY 240 |
| Kentucky | Warren | Rockfield | 127.460 | 205.127 | KY 242 east (Richpond-Rockfield Road) – Rockfield | Western terminus of KY 242 |
| Kentucky | Warren | ​ | 129.180 | 207.895 | KY 1083 north / Murphy Road | Northern terminus of KY 1083 |
| Kentucky | Warren | Bowling Green | 131.615 | 211.814 | KY 432 north (Blue Level Road) | Southern terminus of KY 432 |
| Kentucky | Warren | Bowling Green | 132.153– 132.467 | 212.680– 213.185 | I-165 to I-65 – Kentucky State Police, Owensboro | I-165 Exit 6 |
| Kentucky | Warren | Bowling Green | 133.493 | 214.836 | US 231 south (Campbell Lane) / US 68 Bus. east (Russellville Road) to I-165 | Western end of Bowling Green business route; western end of US 231 concurrency; I-165 via 231 south |
| Kentucky | Warren | Bowling Green | 134.975 | 217.221 | US 231 Bus. south / US 231 north (Morgantown Road) to I-165 | Northern terminus of US 231 business; eastern terminus of US 231 concurrency; college via 231 business |
| Kentucky | Warren | Bowling Green | 135.817 | 218.576 | KY 2665 (Glen Lily Road) | |
| Kentucky | Warren | Bowling Green | 136.755 | 220.086 | KY 1435 north (Barren River Road) | Southern terminus of KY 1435 |
| Kentucky | Warren | Bowling Green | 138.621 | 223.089 | KY 185 north | Southern terminus of KY 185; road continues as Gordon Avenue south of intersection |
| Kentucky | Warren | Bowling Green | 138.930 | 223.586 | US 68 Bus. west (Adams Street) / KY 234 south (East 7th Street) – Western Kentucky University | Eastern end of Bowling Green bus. route; northern terminus of KY 234; WKU Health Services via 234 |
| Kentucky | Warren | Bowling Green | 139.407 | 224.354 | US 31W south (East Riverview Drive) / Riverview Drive – Beech Bend Park | Western end of US 31W concurrency; Commonwealth Regional Specialty Hospital just east of intersection; Beech Bend via Riverview Drive |
| Kentucky | Warren | Bowling Green | 140.859 | 226.691 | KY 3225 west (River Street) | Eastern terminus of KY 3225; former alignment of 31W |
| Kentucky | Warren | Bowling Green | 141.826 | 228.247 | KY 1402 east (Porter Pike) | Western terminus of KY 1402 |
| Kentucky | Warren | Bowling Green | 142.108 | 228.701 | KY 446 east to I-65 – Nashville, Louisville, National Corvette Museum | Interchange |
| Kentucky | Warren | Bowling Green | 142.822 | 229.850 | KY 957 north (Plum Springs Loop) | Southern terminus of KY 957 |
| Kentucky | Warren | Bowling Green | 145.141 | 233.582 | KY 526 west (Mount Olivet Road) / Scottys Way | Eastern terminus of KY 526 |
| Kentucky | Warren | Bowling Green | 145.642 | 234.388 | US 31W north (Louisville Road) to I-65 north | Eastern end of US 31 concurrency |
| Kentucky | Warren | Bowling Green | 146.777 | 236.215 | KY 3145 south to I-65 – Nashville, Louisville | Ramp to KY 3145 south and ramp from KY 3145 north |
| Kentucky | Warren | ​ | 150.936 | 242.908 | I-65 south – Nashville | Entrance to southbound I-65 and ramp from northbound I-65; I-65 north exit 36 |
| Kentucky | Warren | ​ | 152.641 | 245.652 | KY 101 (Smiths Grove-Scottsville Road) to I-65 | I-65 to the north |
| Kentucky | Warren | ​ | 156.969 | 252.617 | KY 259 north | Southern terminus of KY 259 |
| Kentucky | Barren | ​ | | | KY 2240 south (Mary Oaks-Ralton Road) | Northern terminus of KY 2240 |
| Kentucky | Barren | Bon Ayr | 161.649 | 260.149 | KY 255 (Bon Ayr Road / Park City-Bon Ayr Road) | |
| Kentucky | Barren | ​ | 165.561 | 266.445 | KY 2189 north (Glasgow Road) | Southern terminus of KY 2189 |
| Kentucky | Barren | Glasgow | 167.727 | 269.930 | KY 3600 west (Veterans Outer Loop) / US 68 Bus. east (New Glasgow Road) to Cumberland Parkway | Eastern terminus of KY 3600; western end of Glasgow business route; Parkway via 3600 |
| Kentucky | Barren | Glasgow | 169.004 | 271.986 | KY 90 (Happy Valley Road) to I-65 north – Cave City | Glasgow Memorial Airport to the northwest |
| Kentucky | Barren | Glasgow | 170.939 | 275.100 | US 31E (North Jackson Highway) | TJ Samson Community Hospital to the south |
| Kentucky | Barren | Glasgow | 173.226 | 278.780 | US 68 Bus. west (Edmonton Road) / KY 1519 south (Veterans Outer Loop) to Cumberland Parkway | Eastern end of Glasgow business route; northern terminus of KY 1519; Parkway via 1519 |
| Kentucky | Barren | ​ | 173.405 | 279.068 | KY 740 north (Coral Hill Road) | Southern terminus of KY 740 |
| Kentucky | Metcalfe | Wisdom | 182.491 | 293.691 | KY 640 (Wisdom Road / Knob Lick-Wisdom Road) | |
| Kentucky | Metcalfe | ​ | 186.216– 186.495 | 299.686– 300.135 | Cumberland Parkway – Bowling Green, Somerset | Cumberland Parkway exit 37 |
| Kentucky | Metcalfe | Edmonton | 188.534 | 303.416 | KY 861 west (Randolph Street) – Metcalfe Co. Schools, Metcalfe Co. Board of Education | Eastern terminus of KY 861 |
| Kentucky | Metcalfe | Edmonton | 189.399 | 304.808 | KY 163 south (South Main Street) / East Stockton Street | Northern terminus of KY 163 |
| Kentucky | Metcalfe | Edmonton | 189.839 | 305.516 | KY 80 east (North Main Street) – Columbia | Eastern end of KY 80 concurrency |
| Kentucky | Metcalfe | ​ | 190.707 | 306.913 | KY 3524 east (Industrial Drive) / Harvey Hunt Road | Western terminus of KY 3524 |
| Kentucky | Metcalfe | ​ | 190.787– 191.010 | 307.042– 307.401 | Cumberland Parkway – Somerset, Bowling Green | Cumberland Parkway exit 29 |
| Kentucky | Metcalfe | ​ | 191.172 | 307.662 | KY 1243 north (Knob Lick Road) | Southern terminus of KY 1243 |
| Kentucky | Metcalfe | ​ | 192.331 | 309.527 | KY 2399 east (A H Boston Road) / Lawrence England Road | Western terminus of KY 2399 |
| Kentucky | Metcalfe | ​ | 193.840 | 311.955 | KY 544 east (Bridgeport-Keltner Road) | Western terminus of KY 544 |
| Kentucky | Metcalfe | ​ | 195.503 | 314.632 | KY 543 west (Toby Hill Road) | Eastern terminus of KY 543 |
| Kentucky | Metcalfe | ​ | 198.672 | 319.732 | KY 70 west (Sulphur Well-Knob Lick Road) – Cave City | Western end of KY 70 concurrency |
| Kentucky | Metcalfe | ​ | 199.688 | 321.367 | KY 745 south (Mill Ridge Road) | Northern terminus of KY 745 |
| Kentucky | Green | ​ | 201.279 | 323.927 | KY 729 north (Little Barren Road) | Southern terminus of KY 729 |
| Kentucky | Green | Exie | 205.429 | 330.606 | KY 487 north (Mell Road) | Southern terminus of KY 487 |
| Kentucky | Green | ​ | 206.952 | 333.057 | KY 218 west – Horse Cave | Eastern terminus of KY 218 |
| Kentucky | Green | ​ | 212.740 | 342.372 | KY 61 south (Columbia Highway) – Columbia, Burkesville | Western end of KY 61 concurrency |
| Kentucky | Green | Greensburg | 212.994 | 342.781 | Milby Street – Jane Todd Crawford Memorial Hospital | |
| Kentucky | Green | Greensburg | 213.114 | 342.974 | Industrial Road | Former KY 2189 |
| Kentucky | Green | Greensburg | 213.818– 213.950 | 344.107– 344.319 | Bridge over the Green River | Bridge over the Green River |
| Kentucky | Green | Greensburg | 214.208 | 344.734 | KY 417 east (East Columbia Avenue) / West Columbia Avenue | Western terminus of KY 417 |
| Kentucky | Green | Greensburg | 215.110 | 346.186 | KY 61 north / KY 3535 south (Industrial Park Drive) – Industrial Park, Health Dept, Hodgenville | Eastern end of KY 61 conncurrency; northern terminus of KY 3535; Industrial park and health dept. via 3535 |
| Kentucky | Green | ​ | 217.451 | 349.953 | KY 793 west | Eastern terminus of KY 793 |
| Kentucky | Taylor | ​ | 219.264 | 352.871 | KY 2764 west (Miller Road) | Eastern terminus of KY 2764; road continues as Miller Road east/south of US 68 |
| Kentucky | Taylor | ​ | 220.513 | 354.881 | KY 883 north (Shiloh Road) | Southern terminus of KY 883 |
| Kentucky | Taylor | Campbellsville | 223.209 | 359.220 | KY 323 (West Main Street / Friendship Pike) | |
| Kentucky | Taylor | Campbellsville | 224.104 | 360.660 | KY 55 south (New Columbia Road) / KY 210 west (Hodgenville Road) – Columbia, Battle of Tebb's Bend Monument, Green River Lake, Hodgenville | Western end of KY 55 concurrency; eastern terminus of KY 210 |
| Kentucky | Taylor | Campbellsville | 224.868 | 361.890 | North Hoskins Avenue – Campbellsville University | |
| Kentucky | Taylor | Campbellsville | 224.921 | 361.975 | KY 323 south (South Columbia Avenue) | Northern terminus of KY 323 |
| Kentucky | Taylor | Campbellsville | 225.041 | 362.168 | KY 70 east / KY 527 north (North Central Avenue) | Eastern end of KY 70 concurrency; southern terminus of KY 527; 527 to the left, 70 to the right |
| Kentucky | Taylor | Campbellsville | 225.157 | 362.355 | KY 289 north (Lebanon Avenue) | Southern terminus of KY 289; access to Taylor Regional Hospital |
| Kentucky | Taylor | Campbellsville | 225.937 | 363.610 | KY 658 east (Roberts Road) / Cherokee Drive | Western terminus of KY 658 |
| Kentucky | Taylor | Campbellsville | 226.638 | 364.739 | KY 1799 south (Airport Road) – Taylor County Airport | Northern terminus of KY 1799 |
| Kentucky | Taylor | ​ | 227.858 | 366.702 | KY 3211 west (Palestine Road) / Rinehart Road | Eastern terminus of KY 3211 |
| Kentucky | Taylor | ​ | 228.764 | 368.160 | KY 1834 east (Sportsman Lake Road) – Spurlington Lake | Western terminus of KY 1834 |
| Kentucky | Taylor | ​ | 231.113 | 371.940 | KY 208 north / KY 744 (Spurlington Road / Newton Lane) – Spurlington, Calvary, Spurlington Lake | Southern terminus of KY 208; 744 goes both ways |
| Kentucky | Marion | ​ | 234.915 | 378.059 | KY 412 west / Willard Farm Lane | Western end of KY 412 concurrency |
| Kentucky | Marion | ​ | 237.268 | 381.846 | KY 412 east (East Calvary Road) | Eastern end of KY 412 concurrency |
| Kentucky | Marion | ​ | 239.410 | 385.293 | KY 289 south | Northern terminus of KY 289 |
| Kentucky | Marion | ​ | 240.362 | 386.825 | KY 2741 south (McElroy Pike) | Northern terminus of KY 2741 |
| Kentucky | Marion | ​ | 241.394 | 388.486 | KY 426 west (Miller Pike) / Old KY 68 | Eastern terminus of KY 426 |
| Kentucky | Marion | ​ | 242.129 | 389.669 | KY 2154 (Adam Hughes Memorial Highway / Veterans Memorial Highway) | |
| Kentucky | Marion | Lebanon | 243.455 | 391.803 | KY 55 north (West Walnut Street) / Hamilton Heights | Eastern end of KY 55 concurrency; access to Spring View Hospital; 55 also provides access to Lebanon-Springfield Airport |
| Kentucky | Marion | Lebanon | 243.961 | 392.617 | KY 49 / KY 52 west (North Proctor Avenue / South Proctor Avenue) – Liberty, Presbyterian Cemetery, The Kobert Place | Western end of KY 52 concurrency; 49 both ways |
| Kentucky | Marion | Lebanon | 244.074 | 392.799 | KY 55 Spur south (North Spalding Avenue) to KY 55 / South Spalding Avenue – Maxwell House, Visitor Center, Lebanon Civil War Park, Myrtledene | Northern terminus of KY 55 spur |
| Kentucky | Marion | Lebanon | 245.087 | 394.429 | KY 2154 north (Corporate Drive) / Sulphur Springs Road – Springfield | Southern terminus of KY 2154 |
| Kentucky | Marion | Lebanon | 245.924 | 395.776 | KY 1404 north (Barbers Mill Road) | Southern terminus of KY 1404 |
| Kentucky | Marion | ​ | 246.520 | 396.735 | KY 1195 north (Shortline Pike) | Southern terminus of KY 1195 |
| Kentucky | Marion | ​ | 255.199 | 410.703 | KY 243 south (Gravel Switch Road) – Gravel Switch, Bradfordsville | Northern terminus of KY 243 |
| Kentucky | Boyle | ​ | 258.540 | 416.080 | KY 34 east (Lebanon Road) – Lebanon | Western terminus of KY 34 |
| Kentucky | Boyle | ​ | 260.903 | 419.883 | KY 1894 south (Brumfield Road) | Northern terminus of KY 1894 |
| Kentucky | Boyle | Perryville | 262.958 | 423.190 | US 150 west (West 2nd Street) / North Buell Street – Perryville Battlefield State Park, Springfield | Western end of US 150 concurrency |
| Kentucky | Boyle | Perryville | 236.067 | 379.913 | US 150 east / KY 52 east (East 2nd Street) / KY 1856 south (South Bragg Street) – Danville | Eastern end of US 150 and KY 52 concurrencies; 52/150 continue east, 68 turns north |
| Kentucky | Boyle | ​ | 266.181 | 428.377 | KY 1941 north (Martin Lane) | Southern terminus of KY 1941 |
| Kentucky | Mercer | Nevada | 267.104 | 429.862 | KY 1822 south (Quirks Run Road) | Northern terminus of KY 1822 |
| Kentucky | Mercer | ​ | 272.005 | 437.750 | KY 1915 south (Dry Branch Road) | Northern terminus of KY 1915 |
| Kentucky | Mercer | Harrodsburg | 273.038 | 439.412 | KY 152 west (Mooreland Avenue) – Springfield | Western end of KY 152 concurrency |
| Kentucky | Mercer | Harrodsburg | 273.340 | 439.898 | US 127 south (South College Street) / Mooreland Avenue – Danville | Western end of US 127 concurrency |
| Kentucky | Mercer | Harrodsburg | 273.519 | 440.186 | US 127 north (North College Street) / West Lexington Street – Lawrenceburg, Old Fort Harrod State Park | Eastern end of US 127 concurrency; 127 continues north, 68/152 turn east |
| Kentucky | Mercer | Harrodsburg | 273.935 | 440.856 | KY 152 east (Cane Run Road) / Marimon Avenue – Herrington Lake, Burgin | Eastern end of KY 152 concurrency |
| Kentucky | Mercer | Harrodsburg | 274.879 | 442.375 | US 127 Byp. | |
| Kentucky | Mercer | ​ | 276.402 | 444.826 | KY 1343 north (Curry Pike) | Southern terminus of KY 1343 |
| Kentucky | Mercer | Pleasant Hill | 280.940 | 452.129 | KY 33 south (Shakertown Road) – Burgin, Herrington Lake, Danville | Western end of KY 33 concurrency; Shaker Village on north side of intersection |
| Kentucky | Kentucky River | Kentucky River | 286.481– 286.599 | 461.046– 461.236 | Brooklyn Bridge | Brooklyn Bridge |
| Kentucky | Jessamine | ​ | 288.054 | 463.578 | KY 33 north (Pekin Pike) – Versailles | Eastern end of KY 33 concurrency |
| Kentucky | Jessamine | ​ | 288.716 | 464.643 | KY 1268 south (West Main Street) – Wilmore, Asbury University | Northern terminus of KY 1268 |
| Kentucky | Jessamine | ​ | 290.905 | 468.166 | KY 29 south (Lexington Road) / Cardinal Drive – Wilmore, Asbury University | Western end of KY 29 concurrency |
| Kentucky | Jessamine | ​ | 291.632 | 469.336 | KY 29 north / Murphy Lane – Nicholasville | Eastern end of KY 29 concurrency |
| Kentucky | Jessamine | ​ | 293.757 | 472.756 | KY 169 (Keene Road) – Nicholasville | |
| Kentucky | Jessamine | ​ | 295.837 | 476.104 | KY 3375 (Catnip Hill Road) – Springhouse Gardens | |
| Kentucky | Jessamine | Brannon Woods | 297.615 | 478.965 | KY 1980 east (Brannon Road) / West Brannon Road | Western terminus of KY 1980 |
| Kentucky | Fayette | Lexington | 299.233 | 481.569 | KY 1267 south (Keene Road) / Old Schoolhouse Lane | Northern terminus of KY 1267 |
| Kentucky | Fayette | Lexington | 300.234 | 483.180 | Man o' War Boulevard | |
| Kentucky | Fayette | Lexington | 301.582– 301.748 | 485.349– 485.616 | KY 4 south (West New Circle Road) | Diverging diamond interchange; KY 4 exit 2 |
| Kentucky | Fayette | Lexington | 304.204 | 489.569 | US 27 south (Virginia Avenue) / Red Mile Road – University of Kentucky | Western end of US 27 concurrency |
| Kentucky | Fayette | Lexington | 304.758 | 490.460 | KY 922 north (Oliver Lewis Way) to I-75 / I-64 / Bolivar Street | Southern terminus of KY 922 |
| Kentucky | Fayette | Lexington | 305.227 | 491.215 | US 25 north / US 421 north (West Vine Street) – Ashland (Henry Clay estate), Cheapside Park | |
| Kentucky | Fayette | Lexington | 305.289 | 491.315 | US 25 south / US 421 south (West Main Street) | |
| Kentucky | Fayette | Lexington | 307.242 | 494.458 | KY 4 (New Circle Road) | |
| Kentucky | Fayette | Lexington | 308.299– 308.430 | 496.159– 496.370 | I-75 / I-64 – Knoxville, Ashland | Interchange. I-75/64 exit 112 |
| Kentucky | Fayette | Lexington | 310.820 | 500.216 | KY 3367 east (Johnstown Road) | Western terminus of KY 3367 |
| Kentucky | Fayette | Lexington | 311.554 | 501.398 | KY 1973 north (Iron Works Pike) / Mahmoud Lane | Western end of KY 1973 concurrency |
| Kentucky | Fayette | Lexington | 313.053 | 503.810 | KY 1973 south (Muir Station Road) | Eastern end of KY 1973 concurrency |
| Kentucky | Bourbon | ​ | 315.680 | 508.038 | KY 1939 north (Hutchison Road) | Southern terminus of KY 1939 |
| Kentucky | Bourbon | Paris | 321.164 | 516.863 | KY 1939 (Bethlehem Road / Hume Bedford Pike) | |
| Kentucky | Bourbon | Paris | 321.324 | 517.121 | US 68 Bus. east (South Main Street) | Western terminus of Paris business route; Bourbon Medical Center just northeast of intersection |
| Kentucky | Bourbon | Paris | 322.872 | 519.612 | US 460 (Georgetown Road) – Paris, Georgetown | |
| Kentucky | Bourbon | Paris | 323.290 | 520.285 | US 27 north (Cynthiana Road) – Cynthiana | Eastern end of US 27 concurrency |
| Kentucky | Bourbon | Paris | 325.650 | 524.083 | US 68 Bus. west (Millersburg Road) to US 460 east | Eastern terminus of Paris business route |
| Kentucky | Bourbon | Paris | 325.731 | 524.213 | KY 1940 north (Ruddles Mill Road) – Ruddels Mills | Southern terminus of KY 1940 |
| Kentucky | Bourbon | ​ | 322.047 | 518.284 | US 68 Bus. east (Millersburg Road) – Millersburg | Western terminus of Millersburg business route |
| Kentucky | Bourbon | ​ | 322.487 | 518.993 | KY 1893 (Millersburg-Ruddles Mill Road) – Ruddels Mills | |
| Kentucky | Bourbon | Millersburg | 333.864 | 537.302 | KY 1879 (Millersburg-Cynthiana Road) – Cynthiana | |
| Kentucky | Nicholas | ​ | 334.471 | 538.279 | US 68 Bus. west (Maysville Road) / South Johnson Road | Eastern terminus of Millersburg business route |
| Kentucky | Nicholas | ​ | 335.007 | 539.142 | KY 386 south (Carpenter Pike) | Northern terminus of KY 386 |
| Kentucky | Nicholas | ​ | 336.668 | 541.815 | KY 648 west (Walnut Grove Road) | Eastern terminus of KY 648 |
| Kentucky | Nicholas | ​ | 337.172 | 542.626 | KY 36 (Concrete Road/Old Maysville Road) – Cynthiana, Carlisle | |
| Kentucky | Nicholas | ​ | 339.462 | 546.311 | KY 32 (Old Paris Road) | |
| Kentucky | Nicholas | ​ | 340.499 | 547.980 | KY 1244 north (Old Maysville Road) | Southern terminus of KY 1244 |
| Kentucky | Nicholas | ​ | 340.726 | 548.345 | KY 1455 south (Lake Road) – Lake Carnico, 4-H Camp, Carlisle | Western end of KY 1455 concurrency |
| Kentucky | Nicholas | ​ | 341.463 | 549.531 | KY 1455 north (Mount Mariah Road) | Eastern end of KY 1455 concurrency |
| Kentucky | Nicholas | ​ | 343.709 | 553.146 | KY 606 west (Suggs Road) | Eastern terminus of KY 606 |
| Kentucky | Nicholas | ​ | 345.296 | 555.700 | KY 1244 south (Old Maysville Road) | Northern terminus of KY 1244 |
| Kentucky | Robertson | ​ | 347.126 | 558.645 | Main Park Road – Blue Licks Battlefield State Resort Park | |
| Kentucky | Robertson | ​ | 347.517 | 559.274 | Main Park Road – Blue Licks Battlefield State Resort Park | |
| Kentucky | Robertson | ​ | 348.175 | 560.333 | KY 165 north – Mount Olivet | Western end of KY 165 concurrency |
| Kentucky | Fleming | ​ | 349.754 | 562.875 | KY 2505 north (Mount Pleasant Road) / Willow Road | Southern terminus of KY 2505 |
| Kentucky | Fleming | ​ | 351.982 | 566.460 | KY 165 south (Ewing Road) – Flemingsburg | Eastern end of KY 165 concurrency |
| Kentucky | Mason | ​ | 355.852 | 572.688 | KY 550 south (Metcalfe Mill Pike) / East Bolden Road | Northern terminus of KY 550 |
| Kentucky | Mason | ​ | 357.517 | 575.368 | KY 2517 north (Main Street) | Southern terminus of KY 2157; former routing of US 68 |
| Kentucky | Mason | Mays Lick | 358.468 | 576.898 | KY 324 (Raymond Road) – Mayslick, Sardis, Wedonia | |
| Kentucky | Mason | ​ | 358.953 | 577.679 | KY 2517 south (Main Street) / Ross Road – Mayslick | Northern terminus of KY 2517; former routing of US 68 |
| Kentucky | Mason | ​ | 359.871 | 579.156 | KY 2514 north | Southern terminus of KY 2514 |
| Kentucky | Mason | ​ | 361.599 | 581.937 | KY 2514 south | Northern terminus of KY 2514 |
| Kentucky | Mason | Maysville | 364.094 | 585.952 | US 68 Bus. east – Washington | Western end of Maysville business route |
| Kentucky | Mason | Maysville | 367.608 | 591.608 | AA Hwy (KY 9) south / KY 10 east – Maysville | |
| Kentucky | Mason | Maysville | 368.005 | 592.247 | AA Hwy (KY 9) north / KY 10 west – Brooksville | |
| Kentucky | Mason | Maysville | 370.780 | 596.713 | KY 3056 (Germantown Road / Jersey Ridge Road) | |
| Kentucky | Mason | Maysville | 371.548 | 597.949 | KY 8 (West 2nd Street) – Augusta, Dover, Maysville | interchange |
| Ohio River | Ohio River | Ohio River | 371.730– 372.142 | 598.241– 598.904 | William H. Harsha Bridge | William H. Harsha Bridge |
| Ohio | Brown | Aberdeen | 0.462 | 0.744 | US 52 east / US 62 west – Aberdeen | Southern end of concurrency with US 52 and US 62 |
| Ohio | Brown | Ripley | 6.217 | 10.005 | US 52 west (South 2nd Street) | Northern end of US 52 concurrency |
| Ohio | Brown | Jefferson Township | 11.673 | 18.786 | US 62 east – Russellville | Northern end of US 62 concurrency |
| Ohio | Brown | Pleasant Township | 16.658 | 26.808 | SR 125 east – Russellville, West Union | Southern end of SR 125 concurrency |
| Ohio | Brown | Pleasant Township | 17.678 | 28.450 | SR 125 west (East State Street) – Georgetown | Northern end of SR 125 concurrency |
| Ohio | Brown | Georgetown | 20.649 | 33.231 | Mt. Orab Pike (C-30A) – Georgetown Business District | |
| Ohio | Brown | Mount Orab | 27.930 | 44.949 | SR 774 west / Oakland Road | Eastern terminus of SR 774 |
| Ohio | Brown | Mount Orab | 30.948– 31.041 | 49.806– 49.956 | SR 32 – Jackson, Cincinnati | Interchange |
| Ohio | Brown | Fivemile | 35.462 | 57.071 | SR 286 | |
| Ohio | Brown | Chasetown | 39.280 | 63.215 | SR 131 | |
| Ohio | Brown | Fayetteville | 41.084 | 66.118 | US 50 (East Pike Street / West Pike Street) | |
| Ohio | Brown | Perry Township | 44.479 | 71.582 | SR 123 | |
| Ohio | Clinton | Jefferson Township | 46.395 | 74.666 | SR 251 south | Northern temrinus of SR 251 |
| Ohio | Clinton | Jefferson Township | 50.371 | 81.064 | SR 28 – Blanchester, New Vienna, Martinsville | |
| Ohio | Clinton | Jefferson Township | 54.639 | 87.933 | To SR 350 east – Beach, Marina | |
| Ohio | Clinton | Jefferson Township | 54.720 | 88.063 | To SR 350 west – Clarksville | |
| Ohio | Clinton | Wilmington | 59.993 | 96.549 | SR 134 south | Southern end of SR 134 concurrency |
| Ohio | Clinton | Wilmington | 60.694 | 97.678 | SR 730 south | Northern terminus of SR 730 |
| Ohio | Clinton | Wilmington | 60.927 | 98.053 | US 22 east / SR 3 east (West Main Street) – Wilmington College | |
| Ohio | Clinton | Wilmington | 61.010 | 98.186 | US 22 west / SR 3 west (West Locust Street) | |
| Ohio | Clinton | Wilmington | 61.501 | 98.976 | SR 134 north (North Lorish Avenue) / North South Street | Northern terminus of SR 134 concurrency |
| Ohio | Clinton | Union Township | 62.387– 62.516 | 100.402– 100.610 | SR 73 to I-71 south – Hillsboro, Waynesville | Interchange |
| Ohio | Clinton | Liberty Township | 66.143– 66.351 | 106.447– 106.782 | I-71 – Columbus, Cincinnati | Interchange; I-71 exit 50 |
| Ohio | Greene | Xenia | 77.166– 77.361 | 124.187– 124.500 | US 35 – Washington CH, Dayton | Interchange |
| Ohio | Greene | Xenia | 78.623 | 126.531 | SR 380 south / South Miami Avenue | Southern end of SR 380 concurrency |
| Ohio | Greene | Xenia | 78.994 | 127.129 | US 35 Bus. (East Main Street/West Main Street) / US 42 | Northern terminus of SR 380 |
| Ohio | Greene | Xenia Township | 82.759 | 133.188 | SR 235 north (East Xenia Drive) | Southern terminus of SR 235; roundabout |
| Ohio | Greene | Yellow Springs | 88.173 | 141.901 | Dayton Street to I-675 | |
| Ohio | Greene | Yellow Springs | 88.330 | 142.153 | SR 343 east – Clifton | |
| Ohio | Clark | Green Township | 91.311 | 146.951 | West Blee Road (CR-794) – Springfield Airport | Former SR 794 |
| Ohio | Clark | Springfield Township | 93.829 | 151.003 | Fairfield Pike | At-grade intersection; southern end of freeway |
| Ohio | Clark | Springfield Township | 94.647– 95.041 | 152.320– 152.954 | I-70 – Columbus, Dayton | Interchange;I-70 exits 52A/B |
| Ohio | Clark | Springfield Township | 97.130– 98.215 | 156.316– 158.062 | US 40 / SR 4 – Springfield, Dayton | Interchange; Exits 7A (east) and 7B (west) |
| Ohio | Clark | Springfield Township | 98.545 | 158.593 | SR 41 – Troy, Springfield | Interchange; Exit 8 |
| Ohio | Clark | Springfield | 101.684 | 163.645 | SR 334 east (River Road) – Springfield | Interchange |
| Ohio | Clark–Champaign county line | Bowlusville | 104.835 | 168.716 | County Line Road | Interchange; Exit 15 |
| Ohio | Champaign | Urbana Township | 106.342 | 171.141 | Springfield-Urbana Pike | At-grade intersection; northern end of freeway |
| Ohio | Champaign | Urbana | 110.425 | 177.712 | SR 55 west (Lewis B. Moore Drive) | Eastern terminus of SR 55 |
| Ohio | Champaign | Urbana | 111.381 | 179.250 | US 36 / SR 29 (Miami Street / Scioto Street) | Traffic circle; Mercy Health-Urbana Hospital to the east |
| Ohio | Champaign | Salem Township | 114.744 | 184.663 | SR 296 | |
| Ohio | Champaign | Salem Township | 120.511 | 193.944 | SR 507 east – Ohio Caverns | |
| Ohio | Logan | West Liberty | 121.655 | 195.785 | SR 245 (West Baird Street / East Baird Street) | |
| Ohio | Logan | Liberty Township | 123.211 | 198.289 | SR 508 west | Eastern terminus of SR 508 |
| Ohio | Logan | Bellefontaine | 129.531 | 208.460 | SR 47 east (North Madriver Street) / SR 540 east (East Sandusky Avenue) | Western terminus of SR 540; southern end of SR 47 west concurrency 68 turns west for a block |
| Ohio | Logan | Bellefontaine | 129.631 | 208.621 | US 68 south / SR 47 west (West Sandusky Avenue) / North Main Street | End one-way; 68 south and 47 west to the west, 68 east turns back north |
| Ohio | Logan | Bellefontaine | 130.780– 130.949 | 210.470– 210.742 | US 33 – Marysville, Huntsville, Russells Point | Interchange |
| Ohio | Logan | McArthur Township | 135.547 | 218.142 | SR 638 north | Southern terminus of SR 638 |
| Ohio | Logan | McArthur Township | 136.344 | 219.424 | SR 274 | |
| Ohio | Logan | Rushcreek Township | 140.075 | 225.429 | SR 273 | |
| Ohio | Hardin | Kenton | 150.531 | 242.256 | SR 53 north (East Espy Street) / SR 67 west (West Espy Street) | Southern end of SR 67 concurrency; southern terminus of SR 53 |
| Ohio | Hardin | Kenton | 150.963 | 242.951 | SR 309 (Franklin Street) | |
| Ohio | Hardin | Kenton | 151.029 | 243.058 | SR 67 east (West Columbus Street) | Northern end of SR 67 concurrency |
| Ohio | Hardin | Kenton | 151.109 | 243.186 | SR 31 south (West Carrol Street) | Northern terminus of SR 31 |
| Ohio | Hardin | Blanchard Township | 156.887 | 252.485 | SR 701 west | Eastern terminus of SR 701 |
| Ohio | Hardin | Dunkirk | 160.506 | 258.309 | SR 81 (West Geneva Street / East Geneva Street) | |
| Ohio | Hancock | Madison Township | 163.537– 163.690 | 263.187– 263.434 | US 30 – Mansfield, Fort Wayne | Interchange |
| Ohio | Hancock | Arlington | 168.085 | 270.507 | SR 103 (East Main Cross Street / West Main Cross Street) | |
| Ohio | Hancock | Findlay | 174.751 | 281.234 | SR 15 east – Carey | Interchange |
| Ohio | Hancock | Findlay | 175.917 | 283.111 | SR 15 west | Interchange; eastern end of SR 15 concurrency |
| Ohio | Hancock | Findlay | 178.099 | 286.623 | Lima Avenue – Findlay, Airport | Interchange; former US 25 |
| Ohio | Hancock | Findlay | 178.434 | 287.162 | I-75 / SR 15 north – Dayton, Toledo | Interchange; western end of SR 15 concurrency |
| Ohio | Hancock | Findlay | 178.912 | 287.931 | I-75 | Route ends at I-75 |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus Incomplete access |||||||

## Related routes

* U.S. Route 168
* Special routes of U.S. Route 68
Browse numbered routes :
| ← KY 67 | KY | → KY 69 |
| ← SR 67 | OH | → SR 68 |