# 2016 Uruguay Open – Singles

Guido Pella was the defending champion but chose not to defend his title.
Diego Schwartzman won the title after defeating Rogério Dutra Silva 6–4, 6–1 in the final.

## Seeds

* Nicolás Almagro (quarterfinals)
* Diego Schwartzman (champion)
* Horacio Zeballos (quarterfinals)
* Íñigo Cervantes (quarterfinals)
* Carlos Berlocq (semifinals, retired)
* Rogério Dutra Silva (final)
* Guido Andreozzi (second round, retired)
* Nicolás Kicker (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Cristian Garín | 2 | 2 | | | | |
| 6 | Rogério Dutra Silva | 6 | 6 | | | | |
| 6 | Rogério Dutra Silva | 6 | 6 | 6 | Rogério Dutra Silva | 4 | 1 |
| | | | | 2/WC | Diego Schwartzman | 6 | 6 |
| 5 | Carlos Berlocq | 1 | 1$^r$ | 2/WC | Diego Schwartzman | 6 | 6 |
| 2/WC | Diego Schwartzman | 6 | 4 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1/WC | N Almagro | 7$^7$ | 7$^8$ | | | | | | | | | | | | | | | |
| Q | N Jarry | 6$^4$ | 6$^6$ | | 1/WC | N Almagro | 7 | 6 | | | | | | | | | | |
| | A De Greef | 7$^7$ | 6 | | | A De Greef | 5 | 3 | | | | | | | | | | |
| Q | A Molteni | 6$^2$ | 3 | | | | | | | 1/WC | N Almagro | 6 | 5 | 3 | | | | |
| | H Podlipnik | 3 | 6 | 3 | | | | | | | C Garín | 3 | 7 | 6 | | | | |
| | C Garín | 6 | 3 | 6 | | C Garín | 6 | 3 | | | | | | | | | | |
| WC | M Felder | 0 | 2 | | 7 | G Andreozzi | 4 | 2$^r$ | | | | | | | | | | |
| 7 | G Andreozzi | 6 | 6 | | | | | | | | | | | | | C Garín | 2 | 2 |
| 3 | H Zeballos | 6 | 6 | | | | | | | | | | | | 6 | R Dutra Silva | 6 | 6 |
| | E Gómez | 4 | 4 | | 3 | H Zeballos | 6 | 3 | 6 | | | | | | | | | |
| | JI Londero | 6 | 6 | | | JI Londero | 2 | 6 | 3 | | | | | | | | | |
| | MT Barrios Vera | 0 | 1 | | | | | | | 3 | H Zeballos | 6 | 4 | 2 | | | | |
| | DE Galán | 5 | 7 | 5 | | | | | | 6 | R Dutra Silva | 2 | 6 | 6 | | | | |
| | F Mena | 7 | 5 | 7 | | F Mena | 1 | 2 | | | | | | | | | | |
| Q | M Linzer | 7$^7$ | 2 | 0$^r$ | 6 | R Dutra Silva | 6 | 6 | | | | | | | | | | |
| 6 | R Dutra Silva | 6$^5$ | 6 | 2 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | C Berlocq | 6 | 6 | | | | | | | | | | | | | | | |
| | Juan Ignacio Galarza | 2 | 2 | | 5 | C Berlocq | 6 | 6 | | | | | | | | | | |
| | F Coria | 6 | 6 | | | F Coria | 1 | 2 | | | | | | | | | | |
| | A Collarini | 4 | 1 | | | | | | | 5 | C Berlocq | 3 | 6 | 6 | | | | |
| | C Zampieri | 3 | 7$^7$ | 6 | | | | | | 4 | Í Cervantes | 6 | 4 | 3 | | | | |
| | M Kestelboim | 6 | 6$^5$ | 1 | | C Zampieri | 7 | 2 | 1 | | | | | | | | | |
| | A Velotti | 3 | 4 | | 4 | Í Cervantes | 5 | 6 | 6 | | | | | | | | | |
| 4 | Í Cervantes | 6 | 6 | | | | | | | | | | | | 5 | C Berlocq | 1 | 1$^r$ |
| 8 | N Kicker | 6 | 6 | | | | | | | | | | | | 2/WC | D Schwartzman | 6 | 4 |
| | K Uchida | 2 | 1 | | 8 | N Kicker | 6 | 6 | | | | | | | | | | |
| | Bastián Malla | 6 | 6 | | | B Malla | 1 | 1 | | | | | | | | | | |
| WC | S Maresca | 3 | 4 | | | | | | | 8 | N Kicker | 4 | 6$^4$ | | | | | |
| Q | J Menezes | 2 | 3 | | | | | | | 2/WC | D Schwartzman | 6 | 7$^7$ | | | | | |
| | T Lipovšek Puches | 6 | 6 | | | T Lipovšek Puches | 1 | 3 | | | | | | | | | | |
| | Maximiliano Estévez | 0 | 1 | | 2/WC | D Schwartzman | 6 | 6 | | | | | | | | | | |
| 2/WC | D Schwartzman | 6 | 6 | | | | | | | | | | | | | | | |