OpenLLM-France/wikimedia huggingface dataset:
# Lead compound

A lead compound (/ˈliːd/, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires modification to fit better to the target; lead drugs offer the prospect of being followed by back-up compounds. Its chemical structure serves as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters. Furthermore, newly invented pharmacologically active moieties may have poor druglikeness and may require chemical modification to become drug-like enough to be tested biologically or clinically.

## Terminology

Lead compounds are sometimes called developmental candidates. This is because the discovery and selection of lead compounds occurs prior to preclinical and clinical development of the candidate.

## Discovering lead compounds
### Discovery of a drugable target

Before lead compounds can be discovered, a suitable target for rational drug design must be selected on the basis of biological plausibility or identified through screening potential lead compounds against multiple targets. Drug libraries are often tested by high-throughput screenings (active compounds are designated as "hits") which can screen compounds for their ability to inhibit (antagonist) or stimulate (agonist) a receptor of interest as well as determine their selectivity for them.

### Development of a lead compound

A lead compound may arise from a variety of different sources. Lead compounds are found by characterizing natural products, employing combinatorial chemistry, or by molecular modeling as in rational drug design. Chemicals identified as hits through high-throughput screening may also become lead compounds. Once a lead compound is selected it must undergo lead optimization, which involves making the compound more "drug-like." This is where Lipinski's rule of five comes into play, sometimes also referred to as the "Pfizer rule" or simply as the "rule of five." Other factors, such as the ease of scaling up the manufacturing of the chemical, must be taken into consideration.
# James Ayer

James Ayer may refer to:
* James Cook Ayer (1818–1878), patent medicine businessman
* James H. B. Ayer (1788–1864), mayor of Lowell, Massachusetts
# James Avery (pilot boat)

The James Avery was a 19th-century Sandy Hook pilot boat built in 1837 for a group of New York pilots. She was built by the shipbuilder Jacob Bell. The James Avery was a pilot boat during the American Civil War that helped in the search of the Confederate
. She was last seen in 1872, off the Highlands.

## Construction and service

On September 9, 1837, the pilot boat James Avery was launched from the Brown & Bell shipyard, on the East River, near the Dry Dock. She was built by shipbuilder Jacob Bell. The launch was witnessed by all the pilots of the port, with family and friends. Food was prepared in a sail loft in the shipyard for all to enjoy. Toasts and speeches were made for the success of the James Avery. She was owned by a company of New York pilots. She weighed 80-tons burthen. The boat number "9" was painted as a large number on the mainsail.
On 27 October 1837, Thomas Johnson of the pilot boat James Avery spoke to Captain Barr of the New Jersey Barque Louisa, if wanted to pilot. When he refused, the Louisa, proceeded to run ashore. Johnson went over to the boat and, at Barr's request, sent for assistance.
On 14 December 1840, John Henderson of the pilot boat James Avery, along with other pilots from the port of New York, stated that they had never been employed by J. D. Stevenson and no compensation has been offered or demanded.
On July 3, 1845, John W. Avery placed an ad in the New York Daily Herald saying that pilot boat James Avery picked up the brig Porto Rico of Belfast, Maine, that was abandoned near the Sandy Hook Light, now lying at India Wharf East River. Further information was available with John W. Avery & Co., 309 Water Street, New York City.
In 1860, she was one of only twenty-one New York and New Jersey pilot boats in the New York fleet.
On August 14, 1864, during the American Civil War, the pilot boat James Avery, No. 9 off Tavern House, was boarded by the United States Navy Juniata in search of the Confederate
David S. Nicolay served as boat-keeper on the James Avery, No. 9 from 1866 to 1867. He was transferred to the pilot boat Christianburg, No. 16 in 1867. The Christianburg was later renamed the Ariel Patterson.
During a blizzard in March 1868, the pilot boat James Avery, No. 9, along with other pilot boats, returned and anchored in the Lower New York Bay. John Taylor was aboard the James Avery off Montauk, New York, when the gale caused their boat to capsize. The crew was able to upright the boat and return home.
In 1870, the James Avery was listed along with twenty-two other Sandy Hook pilot boats.
On July 11, 1870, the Hudson Daily Star reported about a fishing excursion from Peck Slip to the Cholera Banks, where the steamer State of Maine spotted the pilot boat James Avery with Captain Joseph Henderson. The pilot on the State of Maine came aboard the Avery. Captain Henderson told the pilot that they were off course and came aboard the steamer to guide the Main to the Cholera Banks.

## End of service

The pilot boat James Avery, No. 9 was last reported on June 16, 1872, having spoken to the Schoolship Mercury twelve miles off the Highlands.
# Ropica cruciata

Ropica cruciata is a species of beetle in the family Cerambycidae. It was described by Breuning in 1939.
# Ropica coenosa

Ropica coenosa is a species of beetle in the family Cerambycidae. It was described by Matsushita in 1933. It is known from Japan.
# Topshop (disambiguation)

Topshop is a British clothes store, formerly known as Top Shop.
Topshop or Top Shop may also refer to:
* Topshop (workshop), a dwelling with work-rooms on the top floor, specific to the English Midlands
* Board Game Top Shop, a 1999 video game for the PlayStation and Sega Saturn
# Rosbach (disambiguation)

Rosbach vor der Höhe is a town in Hesse, Germany.
Rosbach may also refer to:

## Places

* Rosbach vor der Höhe station, a railway station at Rosbach vor der Höhe
* Rosbach, part of the municipality of Windeck in Northrhine-Westphalia, Germany
** Rosbach station, a railway station at Rosbach (Windeck)
* Rosbach (Nidda), a river in Hesse, Germany

## People

* Anna Rosbach (born 1947), Danish politician
* Johan Hammond Rosbach (1921–2004), Norwegian author
* Wilma Rosbach (1921–2018), American politician
# Leessang of Honey Family

Leessang of Honey Family is the debut album by South Korean hip-hop duo Leessang. The album was released on June 27, 2002. The album contains 16 songs.
# Ronnie Stringwell

Ronnie Stringwell is a former amateur cyclist who won the British National Hill Climb Championships at the age of 22 in 1950, and retained the title in 1951. A member of Bramley Wheelers Cycling Club in Leeds, his career was short-lived. He damaged an ankle in an accident when leading in a race on Winnats Pass in November 1951 which ultimately resulted in his early retirement.
Ronnie Stringwell was 22 when he won the National Hill Climb Championship in 1950 on Barbers Hill, Llangollen, North Wales, beating the previous years champion Bob Maitland into second place.
* 1st - R. Stringwell Bramley Wheelers CC - 4 mins 33 2/5secs
* 2nd - B. Maitland Concorde RCC - 4 mins 35 1/5secs
* 3rd - B. Robinson Huddersfield RC - 4 mins 39 secs
In 1951 he repeated his success by winning again at Saintbury Hill in Gloucestershire; he was the only rider other than Ken Joy to retain a championship title won in 1950.
There can be no doubt that he proved himself worthy of this honour with a performance that not only dwarfed his competitors but once again demonstrated the qualities of a true champion. The first climb of note on the day was Peter Proctor whose time stood as fastest for a long while until Brian Robinson rode up in a record time 13 seconds faster than Proctor. No one thought this could be bettered, particularly when the times of riders the calibre of Maitland, Pentecost and Haskell were considered, but the measure of Stringwell’s victory lies in the 4 and 1/5th seconds by which he beat Robinson with Proctor relegated to third place.
* 1st - R. Stringwell Bramley Wheelers CC - 6 mins 26 secs
* 2nd - B. Robinson Huddersfield RC - 6 mins 30 1/5 secs
* 3rd - P. Proctor Western Command CC - 6 mins 43 2/5 secs
Ronnie was member of the winning Bramley Wheelers team in 1953 and the club went on to win the event every year from 1953 to 1959.
* 1953 - 1st: R Stringwell, 2nd: R Franklin, 3rd: F E Buckley
* 1954 - 1st: R Franklin, 2nd: E Harrison, 3rd: F E Buckley
* 1955 - 1st: V Caswell, 2nd: F E Buckley, 3rd: R Franklin
* 1956 - 1st: V Caswell, 2nd: F E Buckley, 3rd: R Franklin
* 1957 - 1st: N A Smith, 2nd: F E Buckley, 3rd: E Harrison
* 1958 - 1st: N A Smith, 2nd: F E Buckley, 3rd: R Franklin
* 1959 - 1st: N A Smith, 2nd: V F Caswell, 3rd: R Franklin
# Ronnie Swan

Ronald McDonald Swan (born 8 January 1941) is a Scottish footballer who played as a goalkeeper in the Football League. He was born in Plean.
# Jesse Briggs

Jesse Briggs (born April 14, 1990) is a Canadian former professional football linebacker who played for the Winnipeg Blue Bombers of the Canadian Football League (CFL). Briggs played CIS football for the McGill Redmen.

## Professional career

Briggs was selected in the second round, 17th overall, in the 2014 CFL Draft by the Winnipeg Blue Bombers. One of just 17 Bomber players to dress for all 18 games that year, Briggs was a regular on the club's punt and kickoff coverage teams. He saw some action on defense making a pair of defensive tackles to go with 11 stops on special team duty. He had three games with multiple special team tackles.
Additionally, in an October 10, 2015 game vs. the BC Lions, Briggs gained 11 yards on a 3rd and 10 fake punt run. After these late game heroics in a pivotal Western Division match up, he had another run in the Banjo Bowl vs. the Saskatchewan Roughriders.
He played in only four regular season games in 2019 due to injury, but returned in the playoffs where he played in all three of the Blue Bombers' post-season games. Briggs played in his first Grey Cup game that year where he recorded one defensive tackle and one special teams tackle as Briggs won his first championship in Winnipeg's victory over the Hamilton Tiger-Cats in the 107th Grey Cup game.
Briggs signed a one-year contract extension with Winnipeg on January 20, 2021. He started his first career game at linebacker on August 13, 2021 against the Toronto Argonauts where he had three defensive tackles and a forced fumble. In the next game on August 21, 2021, again against the Argonauts, he scored his first professional touchdown after returning a fumble 83 yards for a score.
He retired on February 12, 2024.

### Professional statistics

| | | Defense | Defense | Defense | Defense | Defense | Defense | Defense | Defense | Rushing | Rushing | Rushing | Rushing | Rushing |
| Season | Team | GP | GS | DT | STT | Sacks | INT | TD | FF | Att | Yds | Avg | Lng | TD |
| 2014 | WPG | 18 | 0 | 2 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | 0 |
| 2015 | WPG | 18 | 0 | 4 | 11 | 0 | 0 | 0 | 0 | 2 | 14 | 7.0 | 11 | 0 |
| 2016 | WPG | 18 | 0 | 1 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | 0 |
| 2017 | WPG | 15 | 0 | 8 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | 0 |
| 2018 | WPG | 18 | 0 | 3 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | 0 |
| 2019 | WPG | 4 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0 | 0 | 0 |
| Career | Career | 91 | 0 | 20 | 56 | 0 | 0 | 0 | 0 | 2 | 14 | 7.0 | 11 | 0 |
# Tournée Québec Cinéma

The Tournée Québec Cinéma is an annual touring film festival, organized by Québec Cinéma to promote and distribute French language films from Quebec in cities in English Canada where such films would not ordinarily receive theatrical distribution.
In some cities the event is staged as a standalone festival, while in others the organization partners with an established local francophone or international film festival to present a selection of Quebec films within the other festival's program. Standalone events are currently staged in Kelowna, Nelson and Victoria, British Columbia; Caraquet and Moncton, New Brunswick; St. John's, Newfoundland and Labrador; Argyle, Church Point, Greenwood and Halifax, Nova Scotia; Iqaluit, Nunavut; and Charlottetown, North Rustico, Souris and Summerside, Prince Edward Island, while partnerships are in place with Cinéfranco in Toronto, the Festival Objectif Cinéma in Ottawa, Cinémental in Winnipeg, the Rendez-Vous French Film Festival in Vancouver and the Available Light Film Festival in Whitehorse.
The event is considered a qualifying festival for the Canadian Screen Awards.
# Jesús Ramírez

Jesús Ramírez may refer to:
* Jesús Ramírez (Mexican footballer) (born 1957), Mexican footballer and football manager
* Jesús Ramírez (Venezuelan footballer) (born 1998), Venezuelan footballer
* Jesús Emilio Ramírez (1904–1981), Colombian geophysicist and seismologist
* Jesús Ramírez Rangel (born 1978), Mexican politician
* Jesús Ramírez Stabros (born 1963), Mexican politician
# Tous ensemble

"Tous Ensemble" ("All together") is a song recorded in 2002 by French singer Johnny Hallyday. The song was released as a single on 23 April 2002. It was the official anthem of the French football team during the 2002 FIFA World Cup. French singer and songwriter Catherine Lara participated in the writing of the lyrics and produced the song. Michel Sanchez, who was a member of the band Deep Forest, co-wrote the lyrics. The song became the second football anthem to reach the top of the singles chart in France, four years after Ricky Martin's hit "La Copa de la Vida". "Tous Ensemble" became Hallyday's first number-one hit on the modern French SNEP Singles Chart since its establishment in 1984. As of July 2014, it is the 102nd best-selling single of the 21st century in France, with 303,000 units sold.
The current chart was established in 1984. He had over 20 number-1 hits in the 1960s and 1970s.

## Track listings
### CD single

* "Tous ensemble" – 2:45
* "Tous ensemble" (instrumental) – 2:45

## Certifications

| Region | Certification | Certified units/sales |
| France (SNEP) | Platinum | 500,000$^*$ |
| $^*$ Sales figures based on certification alone. |||

## Charts
### Weekly charts

| Chart (2002) | Peak position |
| Belgian (Wallonia) Singles Chart | 11 |
| French SNEP Singles Chart | 1 |

### Year-end charts

| Chart (2002) | Position |
| Belgian (Wallonia) Singles Chart | 74 |
| Europe (Eurochart Hot 100) | 98 |
| French Singles Chart | 14 |
# Tous contre un

Tous contre un was a daily quiz show, broadcast live on Télé-Québec in Canada from September 2001 to March 2003. It was hosted by Marc-André Coallier.
Contestants had to answer questions based on the day's current news. Television viewers could also play on the Internet (in sync with the studio game) and win prizes. The final game of each program pitted the studio winner against 10 Internet contestants. The program's chief innovation was its proprietary computer system which allowed a perfect synchronisation between questions displayed on the television screen and on the Internet players' display screens.
The program was produced by Groupe Tele-Vision Inc. and was created by Eric F. Lemieux and Daniel Cormier.
# Roseville Presbyterian Church

Roseville Presbyterian Church, also known as Roseville United Presbyterian Church, is a church at Roseville & Sussex Avenues in Newark, New Jersey, United States. It was organized and dedicated in 1854 and its current Sanctuary was built in 1867.

## History

The church began in 1852 as Sunday school classes, held at North 7th & Orange Streets, in "Rowe's Village", present day neighborhood of Roseville. In 1853, Aaron Peck, who owned most of present-day Roseville, donated the land on Roseville Avenue, where a small frame church was erected.
On April 9, 1854, Roseville Presbyterian Church was incorporated by the Newark Presbytery and on April 27, Dr. John F Pingry was installed as the first pastor.
In 1867, the center portion of the present sanctuary was built. Designed by Frank F. Ward of Ward & Davis, It was enlarged with wings on either side in 1875. After using the original frame building as a Sunday school house, it was removed and the present red brick building, known as the "Education building" was erected.
In 1907, the building which would eventually house the chapel (and later renovated to house offices and a conference room), was built adjacent to the Education building and connected to the Sanctuary.
In 1913, the Manse was built directly on the corner of Sussex & Roseville Avenues and the kitchen was added to the Education building.
In 1924, Fewsmith Memorial Church at 34 Hudson St merged its 168 members into the congregation.
At the death of Ms. Edith Peck in 1935, the church was bequeathed the homestead of Cyrus Peck. The Peck family were longtime members and benefactors to the church.
Sherrill Hall, the last of the major buildings added to the campus, was completed in 1954 along with a new steeple after a fire destroyed the original.

## Pastors

Roseville has been served by 11 pastors.
* 1854 - 1860: Dr. John F. Pingry
** Resigned to establish The Pingry School.
* 1860 - 1903: Dr. Charles T. Haley
* 1905 - 1924: Dr. William Young Chapman
** Resigned to become President of Bloomfield College & Seminary
* 1924 - 1956: Dr. Walter L. Wallon
* 1957 - 1964: Rev. Leonard Evans
* 1965 - 1972: Rev. Kenneth Blaine Cragg
* 1973 - 1976: Rev. Howard Bryant
* 1978 - 1987: Rev. Oliver Brown II
* 1992 - 1994: Rev. Marvin Williams
* 1997 - 2015: Rev. Doris Glaspy
* 2021 – present: Rev. Toure C. Marshall

### Interim pastors

* 1956 - 1956: Dr. Henry Strock
* 1972 - 1973: Dale Tremper
* 2016 - 2021: Rev. Danny Mitchell
# Lefevrea atromaculata

Lefevrea atromaculata is a species of leaf beetle of the Democratic Republic of the Congo, Uganda and Ivory Coast. It was first described by the British entomologist Gilbert Ernest Bryant in 1932, from specimens collected by the British entomologist Alfred Francis John Gedye from Kampala, Uganda.
# Tove Tellback

Tove Tellback (née Ruth Lilly Margareta Swanstrøm, July 25, 1899 – January 20, 1986) was a Norwegian actress. She made her film debut in 1926 as Berit Glomgaarden in Carl Theodor Dreyer's Glomdalsbruden.

## Family

Tove Tellback was born in Kristiania (now Oslo), Norway as Ruth Lilly Margareta "Toppen" Swanstrøm, the daughter of Lars Magnus Swanstrøm (1868–1939) and Aagot Bjørnson (1872–1968). She married Johan Mølbach-Thellefsen (1897–1973) in 1922, and she performed under the stage name Tove Tellback while using the married name Toppen Mølbach-Thellefsen (a.k.a. Mølback Tellefsen). She married a second time in 1935, to Ludvig Cæsar Martin Aubert (1878–1964).

## Filmography

* 1926: Glomdalsbruden as Berit Glomgaarden
* 1927: Troll-elgen as Ingrid Rustebakke
* 1928: Cafe X as Lilly
* 1933: Vi som går kjøkkenveien as Ellen, Beck's daughter
# Jenny Lawson

Jennifer Lawson (born December 29, 1973) is an American journalist, author and blogger.

## Biography

Lawson is from Wall, Texas and is a graduate of Angelo State University. She is the author of The Bloggess website and formerly wrote the Ill Advised blog, co-authored Good Mom/Bad Mom on the Houston Chronicle, and was a columnist for SexIs magazine. Lawson is well known for her irreverent writing style. She also used to write an advice column called "Ask The Bloggess" for The Personal News Network (PNN.com) until she quit because they stopped paying her. She lives with rheumatoid arthritis, depression, anxiety, avoidant personality disorder, and mild obsessive-compulsive disorder.
Lawson was recognized by the Nielsen ratings as one of the Top 50 Most Powerful Mom Bloggers and Forbes listed thebloggess.com as one of their Top 100 Websites for Women. She was a finalist in the 2010 Weblog awards for Best Writing and Most Humorous Writer, and a finalist in the 2011 Weblog awards for Best Writing, Most Humorous Writer and Weblog of the Year. In 2011 The Huffington Post named her the "Greatest Person of the Day" for her work in raising money for struggling families in December 2010. She was also interviewed on CBC News Network's Connect with Mark Kelley during the fundraising campaign.
Lawson's autobiography called Let's Pretend This Never Happened was released on April 17, 2012, by Amy Einhorn Books. On May 6, 2012, it was the number one New York Times bestseller. The book named Best Humor book in the 2012 Goodreads Choice Awards.
Her second book, Furiously Happy, was released on September 22, 2015. It is a humorous look at Lawson's experience with depression and anxiety disorder, and it debuted in the number 3 spot of New York Times Bestseller list on October 11, 2015. It reached number one on the New York Times Bestseller list on July 3, 2016. The audiobook of Furiously Happy, narrated by Lawson, won an Audie Award for best humor audiobook in 2016.
Lawson's third book, YOU ARE HERE: An Owner's Manual For Dangerous Minds, was released in March 2017. It is an adult coloring book/advice book illustrated and written by the author, and it debuted in the number 2 spot of New York Times Bestseller list on March 26, 2017.
In August 2020, Lawson announced on her blog, The Bloggess, that she would release her next memoir, Broken (in the Best Possible Way), in 2021. It debuted in the number 3 spot of the New York Times bestseller list on April 25, 2021. Broken was awarded Best Humor Book of the Year in the 2021 Goodreads Choice Awards.
In 2019 Lawson opened an independent bookstore and bar, Nowhere Bookshop, in San Antonio, Texas. It was given the 2023 readers' choice award for Best Bookstore in San Antonio by San Antonio Magazine.
# James L. Swanson

James L. Swanson (born February 12, 1959) is an American author and historian famous for his New York Times best-seller Manhunt: The 12-Day Chase for Lincoln's Killer, focusing on the biography of John Wilkes Booth and his plot to kill Lincoln and other cabinet members. For this book he earned an Edgar Award. He is currently a Senior Fellow at the Heritage Foundation and in the past has appeared on C-SPAN on behalf of the Koch-affiliated libertarian CATO Institute think tank.

## Education

Swanson graduated from the University of Chicago with a bachelor's degree in history and from the University of California, Los Angeles School of Law with a J.D. degree. He has held a number of government and think-tank posts in Washington, D.C., including at the United States Department of Justice. He serves on the advisory council of the Ford's Theatre Society.

## Career

Swanson is an Abraham Lincoln scholar and is a member of the Lincoln Bicentennial Commission. His main area of research is on the Lincoln assassination. He has also served in the U.S. Department of Justice.