OpenLLM-France/wikimedia huggingface dataset:
# Calcium:cation antiporter-2

The Ca$^{2+}$:H$^+$ antiporter-2 (CaCA2) family (TC# 2.A.106) is a member of the lysine exporter (LysE) superfamily. Note that this family differs from the calcium:cation antiporter (CaCA) family which belongs to the cation diffusion facilitator (CDF) superfamily. CaCA2 family proteins are found in bacteria, archaea, yeast, plants and animals. This family, previously called the uncharacterized Protein Family 0016 (UPF0016), is well conserved throughout prokaryotes and eukaryotes. They are usually 200-350 amino acyl residues long and exhibit 5-7 transmembrane segments (TMSs).

## Members

The yeast golgi Gcr1-dependent translation factor 1 protein (Gdt1p; TC# 2.A.106.2.3) contributes to Ca$^{2+}$ homeostasis. A yeast gdt1 mutant was found to be sensitive to high concentrations of Ca$^{2+}$. This sensitivity was suppressed by expression of human TMEM165 in yeast. Patch-clamp analyses on human cells indicated that TMEM165 catalyzes Ca$^{2+}$ transport. Defects in TMEM165 affected both Ca$^{2+}$ and pH homeostasis. Gdt1p and TMEM165 are probably Golgi-localized Ca$^{2+}$:H$^+$ antiporters. Modification of the Golgi Ca$^{2+}$ and pH balance could explain the glycosylation defects observed in TMEM165-deficient patients.

## Physiological significance

Defects in the human TMEM165 homologue (TC# 2.A.106.2.2) are the cause of congenital disorder of glycosylation type 2K (CDG2K), an autosomal recessive disorder with variable phenotypes. Affected individuals show psychomotor and growth retardation, and most have short stature. Other features include dysmorphism, hypotonia, eye abnormalities, acquired microcephaly, hepatomegaly, and skeletal dysplasia.
Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and are characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features may reflect the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.

## General transport reaction

The generalized reaction catalyzed by CaCA2 family members is:
Ca$^{2+}$ (cytoplasm) + H$^+$ (golgi lumen) → Ca$^{2+}$ (golgi lumen) + H$^+$ (cytoplasm).
# Fulcaldea

Fulcaldea is a genus of flowering plants in the daisy family.

## Species

There is only one accepted species, Fulcaldea laurifolia, native to Peru and Ecuador.
# John Komnenos

John Komnenos or Comnenus may refer to:
* John Komnenos (Domestic of the Schools) (c. 1015 – 1067), Byzantine general and progenitor of the Komnenian dynasty
* John Komnenos (parakoimomenos) (c. 1070 – after 1118), Byzantine nobleman and official
* John II Komnenos (1087–1143), Byzantine emperor from 1118 to 1143
* John Komnenos (governor of Dyrrhachium) (fl. 1092–1106), Byzantine governor of Dyrrhachium
* John Tzelepes Komnenos, (fl. 1130–1140), Byzantine nobleman who defected to the Seljuk Turks
* John Komnenos Vatatzes (fl. 1132–1182), Byzantine general
* John Doukas Komnenos (1128–1176), military governor of Cyprus
* John Komnenos (son of Andronikos I) (1159–1185), second son and co-emperor of Andronikos I
* John Komnenos the Fat, Byzantine nobleman who attempted a usurpation in 1200
* John Komnenos Asen (fl. 1346–1363), ruler of the Principality of Valona
# Satawali

Satawali is a census town in Lanja-Taluka Ratnagiri district in the Indian state of Maharashtra.
Satavali is a village about 12 miles up the Muchkundi Creek, surrounded by hills, 19 km from Bombay-Goa highway, in a valley with a river called Muchkundi.
Nearby cities are Lanja, Rajapur and Ratnagiri.

## Geography

Satawali is located at coordinates: 16°45'53"N 73°27'22" It has an average elevation of 166 metres (544 feet).
The village is in Taluka Lanja - Ratnagiri district. The national highway popularly known as Mumbai-Goa Highway passes through it. Nearest rail head is Adivali on Konkan Railway which is about 35 km away.

## History

From the time of the Peshva up to 1 August 1879, Satwali was made a sub-division.

## Demographics

Population is more than 12000.

## Climate

The temperatures are often below 10 °C in winters. In summer temperatures jump up to 40 °C.
# Lazarus Rising

Lazarus Rising may refer to:
* Lazarus Rising (novel), a science fiction novel by David Sherman and Dan Cragg
* Lazarus Rising: A Personal and Political Autobiography, an autobiography of John Howard
* "Lazarus Rising" (Supernatural), an episode of Supernatural
# Katie Pasfield

Katie Pasfield (born 25 August 1998) is an Australian figure skater. She is the 2018 Reykjavik International silver medalist, and a two-time Australian national bronze medalist (2017, 2018).
On the junior level, she is the 2016 FBMA Trophy silver medalist, the 2014 Skate Down Under silver medalist and a two-time Australian junior national bronze medalist (2012, 2015).

## Personal life

Pasfield is the daughter of Michael Pasfield, a former competitive figure skater, and sister of Zara Pasfield, who is the 2012 Australian ladies' champion.
Pasfield graduated from Pymble Ladies' College in 2016 and is a student studying a Bachelor of Veterinary Biology/ Doctor of Veterinary Medicine at Sydney University.

### Competitive highlights

International :
| Event | 12–13 | 13–14 | 14–15 | 15–16 | 16–17 | 17–18 | 18–19 |
| Four Continents | | | | 21st | | | |
| CS U.S. Classic | | | | | | | 14th |
| Reykjavik International | | | | | | 2nd | |
| Slovenia Open | | | | | | 16th | |
| International: Junior ||||||||
| Junior Worlds | | | | 35th | | | |
| JGP Austria | | | | 18th | | | |
| JGP Latvia | | | | | | 21st | |
| Asian Open | | | | 8th | | | |
| Bavarian Open | | | 16th | | | | |
| Coupe du Printemps | | 20th | | | | | |
| FBMA Trophy | | | | 2nd | | | |
| Int. Challenge Cup | | | 19th | | | | |
| Jégvirág Cup | | | 5th | | | | |
| Skate Down Under | | | 2nd | | | | |
| National ||||||||
| Australian Champ. | | | | 4th | 3rd | 3rd | WD |
| Australian Junior Champ. | 4th J | 6th J | 6th J | 3rd J | | | |
| J = Junior level; WD = Withdrew ||||||||
# Brinklow Castle

Brinklow Castle, known locally as the Tump, is a medieval castle in the village of Brinklow in the county of Warwickshire between Coventry and Rugby.

## History

Brinklow seems to have first been used as a prehistoric barrow, hence the old English 'hlāw' in the name Brinklow. It was later modified during the late 11th century by Aubrey de Coucy, the first Norman lord of Brinklow, but he left his Earldom in Northumbria and thus lost his lands in England before the writing of the Domesday Book of 1086. However his land and title had not been reassigned by the time of the Domesday survey, so there is a good record of his land holdings. The castle was abandoned during the 13th century for unknown reasons.
Brinklow Castle is a motte-and-bailey castle of grand size: the motte is 12 m high and its original bailey was 121m wide by 152m long. Later it seems that Brinklow's bailey was modified to enclose a smaller area by cutting a ditch and forming a rampart in the middle of the bailey; this seems to suggest that Brinklow slowly declined.
# Calcium-regulated heat stable protein 1

Calcium-regulated heat stable protein 1 (CARHSP1) also known as calcium-regulated heat-stable protein of 24 kDa (CRHSP-24) is a protein that in humans is encoded by the CARHSP1 gene.
# Făleștii Noi

Făleștii Noi is a commune in Făleşti District, Moldova. It is composed of two villages, Făleștii Noi and Pietrosul Nou.
# Licoma

Licoma is a location in the La Paz Department in Bolivia. It is the seat of the Licoma Pampa Municipality, the sixth municipal section of the Inquisivi Province.
# Josef Presser

Josef Presser (1907–1967) was an American artist.

## Biography

Presser was born in 1907 in Lublin, Poland. He emigrated to the United States at the age of 12 and studied at the Boston School of the Museum of Fine Arts. During the 1930s, Presser painted murals as part of the Works Progress Administration program. He settled in New York City where he worked as a painter and teacher. He married fellow artist Agnes Hart (1912-1979) in 1941. The couple had studio space in Woodstock, New York. He was associated with the New York print studio Atelier 17. Presser died in Paris in 1967.
Presser's work is included in the collections of the Metropolitan Museum of Art, the National Gallery of Art, the Smithsonian American Art Museum, and the Whitney Museum of American Art, His papers are in the Smithsonian Archives of American Art.
# Rooke

Rooke is a surname, and may refer to:
* Daphne Rooke (1914–2009), South African author
* Sir Denis Rooke (1924–2008), English engineer
* Sir George Rooke (1650–1709), English admiral
* Hayman Rooke (1723–1806), English major and antiquary
* Irene Rooke (1878-1958), English actress
* Jessie Rooke (1845–1906), Australian women's rights campaigner
* Laurence Rooke (1622–1662), English astronomer
* Leon Rooke (born 1934), Canadian novelist
* Max Rooke (born 1981), Australian footballer
* Jordan (Pamela Rooke) (born 1955), English model and actress
* Robert Levi Rooke (1891–1994), American businessman
* Ronnie Rooke (1911–1985), English footballer
* Steven Rooke, Australian actor
* Thomas Charles Byde Rooke (1806–1858), English physician who married into the royal family of the Kingdom of Hawaii
* William Michael Rooke (1794–1847), Irish composer
# Shijing Township, Shijiazhuang

Shijing Township (Chinese: 石井乡) is a township-level division of Luquan District, Shijiazhuang, Hebei, China.
# Atiqul Haque Chowdhury

Atiqul Haque Chowdhury (15 December 1930 – 17 June 2013) was a prominent media personality in Bangladesh. He significantly contributed to the development of Bangladesh television and radio.

## Biography

Chowdhury began his career as a producer and programme organiser at Radio Pakistan Dhaka in 1960, later joining PTV Dhaka in 1965. Atiqul Haque Chowdhury has been one of the leading personalities actively involved in the BTV in its golden era (from late 1970s to late '80s). He started as a producer and retired as the deputy director general of the state-run TV station in 1991. During his tenure, he made over 450 TV plays. A number of quality radio plays were also written and directed by him.
Atiqul Haque Chowdhury has been entertaining the audience of radio and television by producing many good dramas in the last 50 years. He was committed to experimenting with plays and avoiding the usual way of producing plays. He has also manipulated symbols and allegory. His treatment of symbols and allegory was entertaining as well as thought-provoking. Imbibed with true patriotism he is still on the drama horizon of Bangladesh as a beacon light to inspire his listeners and viewers irrespective of caste, creed and birth.
He was also a guest teacher at the Department of Drama and Dramatics at Jahangirnagar University for 11 years. He later jointed Ekushey Television as an Advisor.

## List of works
### Notable radio productions

* Tagore’s Nosto Nirr and Shesher Kobita
* Sharat Chandra’s Pother Dabi, Srikanto and Debdash
* Abu Ishaque’s Surjo Dighol Bari

### Notable TV productions

* Tagore’s Shesher Kobita, Maloncha, Chokher Bali, Drishtidan, Khoka Babur Prottabortan and Guptadhan
* Shawkat Osman’s Kritodasher Hashi
* Nazmul Alam's Koch O Athocho Pabitra
* Humayun Ahmed’s Kushum
* Enamul Haque’s Ghriho Bashi

### Radio and TV plays written by him, produced by him

* Durbin Diya Dekhun
* Nil Nokshar Shondhaney
* Shukher Upoma
* Babar Kolom Kothai?

## Awards

* Bangla Academy honorary Fellowship (2010) for writing and directing TV plays,
* Sequence of Merit Award from Bangladesh Shilpakala Academy (twice),
* Honorary Doctorate Degree from World Development Council (New Delhi, 1990) for his contribution to TV plays,
* Best TV Producer Award (1976)
# Kamthikhairy Dam

Kamthikhairy Dam, also called Pench Dam, is on the Pench river near Parshivni in the state of Maharashtra, India. The dam was constructed for irrigation, and supplies water to two districts of Maharashtra, Nagpur and Bhandara. The dam is located in the West Pench National Park Range, surrounded by forested hills, and is 54 km north of Nagpur.

## Specifications

The height of the dam above its lowest foundation is 32 m (105 ft), and its length is 1,876 m (6,155 ft). The volume content is 4,928 km$^3$ (1,182 cu mi) and gross storage capacity is 230,000 km$^3$ (55,000 cu mi).
# Gallois (surname)

Gallois is a French surname. Notable people with the surname include:
* Évariste Galois (1811–1832), French mathematician
* Jean Gallois (abbot) (1632–1707), French scholar and abbé
* Jean Gallois (musicologist), pseudonym of French musicologist Jean Gaillard (1929–2022)
* Louis Gallois (born 1944), French businessman, former CEO of EADS (now Airbus)
* Lucien Gallois (1857–1941), French geographer
* Pascal Gallois (born 1959), French bassoonist, conductor and music teacher, brother of Patrick Gallois
* Patrick Gallois (born 1956), French flutist and conductor
* Pierre Marie Gallois (1911–2010), French air force brigadier general
# Jovac

Jovac is a village in the municipality of Ćuprija, Serbia. According to the 2002 census, the village has a population of 1258 people.
# CHD8

Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.

## Function

The gene CHD8 encodes the protein chromodomain helicase DNA binding protein 8, which is a chromatin regulator enzyme that is essential during fetal development. CHD8 is an ATP dependent enzyme.
The protein contains an Snf2 helicase domain that is responsible for the hydrolysis of ATP to ADP. CHD8 encodes for a DNA helicase that function as a transcription repressor by remodeling chromatin structure by altering the position of nucleosomes. CHD8 negatively regulates Wnt signaling. Wnt signaling is important in the vertebrate early development and morphogenesis. It is believed that CHD8 also recruits the linker histone H1 and causes the repression of β-catenin and p53 target genes. The importance of CHD8 can be observed in studies where CHD8-knockout mice died after 5.5 embryonic days because of widespread p53 induced apoptosis.
Recently CD8 has been associated to the regulation of long non-coding RNAs (lncRNAs), and the regulation of X chromosome inactivation (XCI) initiation, via regulation of Xist long non-coding RNA, the master regulator of XCI, though competitive binding to Xist regulatory regions.

## Clinical significance

Mutations in this gene have been linked to a subset of autism cases in human and mouse models.
Mutations in CHD8 could lead to upregulation of β-catenin-regulated genes, in some part of the brain this upregulation can cause brain overgrowth also known as macrocephaly
Some studies have determined the role of CHD8 in autism spectrum disorder (ASD). CHD8 expression significantly increases during human mid-fetal development. The chromatin remodeling activity and its interaction with transcriptional regulators have shown to play an important role in ASD aetiology. The developing mammalian brain has a conserved CHD8 target regions that are associated with ASD risk genes. The knockdown of CHD8 in human neural stem cells results in dysregulation of ASD risk genes that are targeted by CHD8.
# Joué-lès-Tours

Joué-lès-Tours (French pronunciation: , literally Joué near Tours) is a commune in the department of Indre-et-Loire, Centre-Val de Loire, central France.
It is the largest suburb of the city of Tours, and is adjacent to it on the southwest.

## Population

| Year | Pop. | ±% p.a. |
| 1793 | 1,515 | — |
| 1800 | 1,777 | +2.30% |
| 1806 | 1,671 | −1.02% |
| 1821 | 1,700 | +0.11% |
| 1831 | 1,776 | +0.44% |
| 1836 | 1,769 | −0.08% |
| 1841 | 1,791 | +0.25% |
| 1846 | 1,780 | −0.12% |
| 1851 | 1,802 | +0.25% |
| 1856 | 1,845 | +0.47% |
| 1861 | 2,010 | +1.73% |
| 1866 | 2,043 | +0.33% |
| 1872 | 2,106 | +0.51% |
| 1876 | 2,302 | +2.25% |
| 1881 | 2,381 | +0.68% |
| 1886 | 2,470 | +0.74% |
| 1891 | 2,538 | +0.54% |
| 1896 | 2,462 | −0.61% |
| 1901 | 2,466 | +0.03% |
| Year | Pop. | ±% p.a. |
| 1906 | 2,595 | +1.02% |
| 1911 | 2,730 | +1.02% |
| 1921 | 3,143 | +1.42% |
| 1926 | 3,440 | +1.82% |
| 1931 | 4,163 | +3.89% |
| 1936 | 4,704 | +2.47% |
| 1946 | 5,684 | +1.91% |
| 1954 | 6,446 | +1.58% |
| 1962 | 9,074 | +4.37% |
| 1968 | 17,826 | +11.91% |
| 1975 | 27,450 | +6.36% |
| 1982 | 34,704 | +3.41% |
| 1990 | 36,798 | +0.74% |
| 1999 | 36,517 | −0.09% |
| 2007 | 35,836 | −0.24% |
| 2012 | 37,196 | +0.75% |
| 2017 | 37,893 | +0.37% |
| 2020 | 38,750 | +0.75% |
Graphs are unavailable due to technical issues. There is more info on Phabricator and on MediaWiki.org. :
Source: EHESS and INSEE (1968-2017) :

## Toponymy

The name of Joué-lès-Tours appears in its form "Gaudiacus" in the 6th Century. It corresponds to a toponymic type frequently found in Christian Gaule, that gave different variants depending on the region: Joué (west of France), Jouy (center and north), Jouey (east), Gouy (Normandy/Picardy), Gaugeac, Jaujac (south). It is composed of the Christian name "Gaudius", meaning "fortunate", "blessed" (gaudia > joy, in Latin) and with the Gallo-Roman suffix -ACU, meaning "place of", "property of".

## History

Joué-lès-Tours was the site of the 20 December 2014 Tours police station stabbing.

## Controversy

In February 2010 the mayor, Philippe Le Breton, added the word laïcité underneath the French national motto on the town hall's façade.
# Jean's Plan

Jean's Plan is a 1946 British family crime film directed by A.C. Hammond and starring Billie Brooks, Gerald Case and Lyn Evans.

## Plot summary

The daughter of a jeweller attempts to stop her father being robbed.

## Cast

* Billie Brooks - Elsie Higgs
* Gerald Case - Inspector of Police
* Lyn Evans - Mr. Higgs
* Stanley Martin - Police car driver
* Geoffrey Morris - Squire
* Vivian Pickles - Jean Fairfax
* Jimmy Rhodes - Harry
* Maurice Rhodes - Boy with dog
* Edward V. Robson - Mr. Fairfax
* Alan Tilvern - Max
* Anthony Verney - Police orderly
# Josef Prager

Josef Prager (15 November 1886 – 1975) was an Austrian footballer. He played in six matches for the Austria national football team from 1904 to 1910.
# Genaro Estrada

Genaro Estrada (June 2, 1887 – September 29, 1937) was a Mexican statesman, academic, and writer. He was Secretary of Foreign Affairs of Mexico between 1930 and 1932 and the architect of the Estrada Doctrine, which stated that the Mexican government would acknowledge any foreign government, no matter how it came into power. This doctrine would influence Mexican politics all throughout the 20th century.

## Biography

Estrada was born in Mazatlán, Sinaloa. He served as a journalist in Mazatlán early in life and moved to Mexico City in 1912, where he was professor at the Escuela Nacional Preparatoria and entered the capital's cultural and political life. He became involved in government after the Mexican Revolution. By the end of the 1920s he served as ambassador to Spain and minister to Portugal and Turkey. He later became professor at the National Autonomous University of Mexico, where he founded the Academia Mexicana de la Historia. He also published a novel, Pero Galín (1926), and four books of satirical and political poetry. He died in Mexico City in 1937.
# John McCombie

John McCombie (15 June 1849 – 3 September 1926) was a New Zealand gold prospector and miner, mine manager. He was born in Onehunga, Auckland, New Zealand, on 15 June 1849.
# Bambarakanda Falls

Bambarakanda Falls (also known as Bambarakele Falls) is the tallest waterfall in Sri Lanka. With a height of 263 m (863 ft), it ranks as the 461st highest waterfall in the world. Situated in Kalupahana in the Badulla District, this waterfall is 5 km (3.1 mi) away from the A4 Highway. The waterfall was formed by Kuda Oya, which is a tributary of the Walawe River. The Bambarakanda Falls can be found in a forest of pine trees.
# Galloisiana kosuensis

Galloisiana kosuensis is a species of cave-dwelling insect in the family Grylloblattidae. Its type locality is Gosu Cave, South Korea.
# Journal of Public Administration Research and Theory

The Journal of Public Administration Research and Theory is a quarterly peer-reviewed scientific journal covering public administration and public policy studies. It was established in 1991 and is published by Oxford University Press on behalf of the Public Management Research Association, of which it is the official journal. The editor-in-chief is Mary K. Feeney (Arizona State University). Associate Editors are: Stephan Grimmelikhuijsen (UtrechtU), Deneen Hatmaker (UConn), George Krause (UGA), Susan Miller (ASU), Michael Siciliano (UIC), David Suárez (UWash), and Anders Ryom Villadsen (AarhusU). According to the Journal Citation Reports, the journal has a 2020 impact factor of 7.000, ranking it 2nd out of 47 journals in the category "Public Administration" and #7 out of 182 in the category "Political Science". The 5-year impact factor is 8.662, with JPART ranking #1 out of 47 in Public Administration and ranked #4 out of 182 in Political Science. Previous editors include Brad Wright (UGA), Craig Thomas (UWash), Carolyn Heinrich (Vanderbilt), Beryl Radin (Georgetown), Stuart Bretschneider (ASU).
# CHD5

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene. It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.
# Samuel Moore House

Samuel Moore House is a historic house located in the University Heights Historic District in Downtown Madison, Wisconsin. It was placed on the on National Register of Historic Places in 1982, and on the Wisconsin State Register for historic places in 1989.

## Description and history

The Moore House is an example of the mature American Craftsman style architecture in the University Heights Historic District which combines traditional woodwork, design and craftsmanship while adapting features that were in style during the period. It was built in 1912 by a well-known local carpenter, contractor and architect, Charles E. Marks. It exemplifies his influence to the American Craftsman style and also, Prairie School design that was emerging in Madison during that time period. Often compared to Claude and Starck homes, the Moore house has a symmetrical main façade with two matching dormers on the third floor, multi-paned windows and wide overhangs eaves. The exterior façade also mixes wide plank cedar siding on the main floor which transitions to the traditional shake features on the second floor. In addition, Marks built multiple roof lines and bump-outs which give the house a sense of the floor plan within. The interior design features an entrance with heavy oak features. Marks took advantage of local immigrants who were skilled in woodworking from the old country and incorporated their skillful trade throughout the house. During this period, it was common to use solid paneled doors between rooms and entryways. Marks, with his eye for carpentry, had intricate custom made multi-glass paneled pocket and entry doors made for the Moore House which makes this house unique to itself. Marks also enlarged the main staircase which was common in larger homes of this time.
Samuel Moore, an assistant professor of English at University of Wisconsin, lived in this house for 3 years before taking a position as an associate professor at University of Michigan.