# Missouri Route 6

Route 6 is a 211-mile-long (340 km) state highway in the northern part of the U.S. state of Missouri. It travels from I-29 Bus./US 169 in St. Joseph to US 24/US 61 about 6 miles (9.7 km) west of Quincy, Illinois. Route 6, if only a few miles longer in each direction, would be the only state highway to cross Missouri west to east. It is one of the original 1922 highways in Missouri.

## Major intersections

| County | Location | mi | km | Destinations | Notes |
| Buchanan | St. Joseph | 0.0 | 0.0 | I-29 BL / US 169 (Belt Highway / Frederick Boulevard) | |
| Buchanan | St. Joseph | 0.5 | 0.80 | I-29 / US 71 – Council Bluffs, Kansas City | I-29 exit 47 |
| DeKalb | ​ | 13.0 | 20.9 | Route 31 south to US 36 | west end of Route 31 overlap |
| DeKalb | Oak | 22.9 | 36.9 | Route 31 north – King City | east end of Route 31 overlap |
| DeKalb | Maysville | 32.0 | 51.5 | Route 33 south / Route A north | |
| Daviess | ​ | 43.7 | 70.3 | I-35 – Bethany, Des Moines, Cameron, Kansas City | I-35 exit 64 |
| Daviess | ​ | 45.7 | 73.5 | US 69 north – Pattonsburg | west end of US 69 overlap |
| Daviess | ​ | 46.8 | 75.3 | US 69 south – Winston | east end of US 69 overlap |
| Daviess | Gallatin | 55.3 | 89.0 | Route 13 south – Hamilton | west end of Route 13 overlap |
| Daviess | ​ | 56.9 | 91.6 | Route 13 north – Jameson | east end of Route 13 overlap |
| Daviess | ​ | 66.0 | 106.2 | Route 190 – Edinburg, Jamesport | |
| Grundy | ​ | 75.0 | 120.7 | Route 146 west / Route W south – Edinburg, Hickory, Crowder State Park | |
| Grundy | Trenton | 78.9 | 127.0 | US 65 Bus. north (Oklahoma Avenue) | west end of US 65 Bus. overlap |
| Grundy | Trenton | 79.0 | 127.1 | US 65 – Princeton, Chillicothe | interchange; east end of US 65 Bus. overlap |
| Grundy | ​ | 92.4 | 148.7 | Route 139 north – Osgood | west end of Route 139 overlap |
| Sullivan | Humphreys | 95.2 | 153.2 | Route 139 south – Meadville | east end of Route 139 overlap |
| Sullivan | ​ | 104.4 | 168.0 | Route 5 south – Linneus | west end of Route 5 overlap |
| Sullivan | ​ | 107.6 | 173.2 | Route 5 Bus. north – Milan | |
| Sullivan | Milan | 110.3 | 177.5 | Route 5 Bus. south | |
| Sullivan | Milan | 110.5 | 177.8 | Route 5 north – Unionville | east end of Route 5 overlap |
| Sullivan | Green City | 119.7 | 192.6 | Route 129 – Green City, Winigan | |
| Adair | ​ | 127.7 | 205.5 | Route 149 south to Route 11 | west end of Route 149 overlap |
| Adair | Novinger | 133.7 | 215.2 | Route 149 north – Connelsville | east end of Route 149 overlap |
| Adair | ​ | 137.5 | 221.3 | Route 157 south – Thousand Hills State Park | |
| Adair | Kirksville | 140.8 | 226.6 | US 63 Bus. north – Lancaster | west end of US 63 Bus. overlap |
| Adair | Kirksville | 142.4 | 229.2 | US 63 Bus. – Macon | east end of US 63 Bus. overlap |
| Adair | Kirksville | 143.4 | 230.8 | US 63 north / Route 11 north – Lancaster, Adair | west end of US 63/MO 11 overlap |
| Adair | Kirksville | 145.4 | 234.0 | US 63 south / Route 11 south – Macon, Kirksville | east end of US 63/MO 11 overlap |
| Knox | ​ | 166.5 | 268.0 | Route 15 south – Plevna | west end of Route 15 overlap |
| Knox | Edina | 167.4 | 269.4 | Route 15 north – Memphis | east end of Route 15 overlap |
| Lewis | ​ | 188.5 | 303.4 | Route 16 east – Monticello | |
| Lewis | Ewing | 195.5 | 314.6 | Route 156 west – Newark, Henry Sever Lake Conservation Area | |
| Lewis | ​ | | | Outer Road - Taylor | |
| Marion | ​ | 211 | 340 | US 24 / US 61 (Avenue of the Saints) – Canton, Quincy, IL, Palmyra, Hannibal | interchange |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus ||||||