# U.S. Route 301 in South Carolina

U.S. Route 301 (US 301) is a 189.704-mile (305.299 km) U.S. Highway that travels north–south from the Savannah River southwest of Allendale to Hamer approaching the South of the Border roadside attraction complex.

## Route description

US 301 enters South Carolina over the Savannah River southwest of Allendale. In Allendale, it has a short Concurrency with US 278. Additional concurrencies include US 321 in and around Ulmer, US 601 between Bamberg and Orangeburg, then US 15 and shortly afterwards Interstate 95 (I-95) in Santee, at exit 97 before all three move across Lake Marion. The US 15-301 concurrency leaves I-95 at exit 102, running in close proximity to I-95, but US 15 breaks away at Summerton, remaining on Church Street while US 301 turns right onto Main Street, which becomes Alvin Hardin Highway. Other concurrencies include US 521 from Manning to Alcolu, US 378 in Turbeville, US 52 between Effingham and just south of Florence, US 76 eastbound from east of Florence until Pee Dee, and finally joins US 501 in Latta, where they both approach the South of the Border roadside attraction complex at the interchange with I-95 on the North–South Carolina border.

## History

US 301 was established in 1932 as a replacement of the piece of US 17-1 north of Wilson and the whole of US 217. Thus US 301 initially ran from US 17 (now US 76) at Pee Dee northeast through Dillon, South Carolina, into North Carolina, and Virginia, ending at U.S. Route 1 in Petersburg, Virginia. This entire route is now paralleled by I-95.
In 1935, US 301 was extended southwest to US 15 at Summerton. This extension took it west on US 76 (formerly US 17) to Florence and south on US 52 (also formerly US 17) to Effingham. There it split to the southwest, running along what had been SC 4 via Manning to Summerton. This again travels parallel to I-95.
In the late 1940s, US 301 was extended again, south all the way towards Tampa, Florida. On the way there from South Carolina it ran along US 15 southwest to Santee, South Carolina and replaced SC 4 west to Orangeburg. From Orangeburg, US 301 ran southwest with U.S. Route 601 to Bamberg, replaced SC 33 to Ulmer, replaced SC 508 to Allendale, and replaced SC 73 to the Georgia state line. When I-95 was built across Lake Marion in 1968, US 301 and 15 traveled parallel to it until they were relocated in a triple concurrency in 1987. In 2007, US 301 was rerouted on new 7.51-mile (12.09 km) bypass routing southeast of Florence.

### U.S. Route 217

U.S. Route 217 (US 217) was an original U.S. Highway, established in 1927. A renumbering of SC 23, it traversed from US 17, in Pee Dee, north through Latta and Dillon before entering North Carolina. In 1932, the entire route was renumbered as US 301.

## Major intersections

| County | Location | mi | km | Exit | Destinations | Notes |
| Savannah River | Savannah River | 0.000 | 0.000 | | US 301 south (SR 73 south) – Sylvania | Continuation into Georgia |
| Burtons Ferry Bridge ||
| Allendale | ​ | 5.680 | 9.141 | | SC 3 (River Road) – Estill, Barnwell | |
| Allendale | Allendale | 12.890 | 20.744 | | US 278 east / SC 125 north – Hampton, Savannah River Site, Augusta | Southern end of US 278 concurrency; southern terminus of SC 125 |
| Allendale | Allendale | 13.200 | 21.243 | | US 278 west (Barnwell Road) – Barnwell | Northern end of US 278 concurrency |
| Allendale | ​ | 14.340 | 23.078 | | SC 641 east (Confederate Highway) – Walterboro | Western terminus of SC 641 |
| Allendale | Ulmer | 21.420 | 34.472 | | SC 300 north – Barnwell | Southern terminus of SC 300 |
| Allendale | Ulmer | 21.960 | 35.341 | | US 321 south – Fairfax, Savannah | Southern end of US 321 concurrency |
| Salkehatchie River | Salkehatchie River | | | | Bufords Bridge | Bufords Bridge |
| Bamberg | ​ | 23.860 | 38.399 | | US 321 north (Carolina Highway) – Olar, Denmark, Columbia | Northern end of US 321 concurrency |
| Bamberg | ​ | 26.540 | 42.712 | | SC 64 east (Lowcountry Highway) – Ehrhardt, Walterboro | Southern end of SC 64 concurrency |
| Bamberg | ​ | 26.800 | 43.130 | | SC 64 west (Lowcountry Highway) – Olar | Northern end of SC 64 concurrency; to Cathedral Bay Heritage Preserve |
| Bamberg | Bamberg | 38.740 | 62.346 | | US 601 south (Broxton Bridge Road) – Hampton | Southern end of US 601 concurrency |
| Bamberg | Bamberg | 39.620 | 63.762 | | US 78 – Denmark, Branchville | |
| South Edisto River | South Edisto River | | | | Bridge | Bridge |
| Orangeburg | ​ | 45.280 | 72.871 | | SC 332 west (Slab Landing Road) – Cope, Norway | Eastern terminus of SC 332 |
| Orangeburg | ​ | 52.060 | 83.782 | | SC 70 west (Binnicker Bridge Road) – Denmark, Barnwell | Eastern terminus of SC 70 |
| Orangeburg | Edisto | 55.140 | 88.739 | | SC 4 west (Neeses Road) – Neeses | Southern end of SC 4 concurrency |
| Orangeburg | Orangeburg | 56.990 | 91.717 | | SC 33 north (Russell Street) | Southern terminus of SC 33 |
| Orangeburg | Orangeburg | 57.160 | 91.990 | | US 601 Truck north / SC 4 east (Stonewall Jackson Street) / Riverside Drive north – Orangeburg National Fish Hatchery, Airport, Orangeburg Arts Center | Northern end of SC 4 concurrency; southern terminus of US 601 Truck |
| Orangeburg | Orangeburg | 57.610 | 92.714 | | US 178 Bus. (Broughton Street) – North, Bowman | |
| Orangeburg | Orangeburg | 58.170 | 93.616 | | US 601 north / US 21 Bus. (Magnolia Street) – Charleston, St. Matthews, Columbia | Northern end of US 601 concurrency; to Fairgrounds |
| Orangeburg | Orangeburg | 59.600 | 95.917 | | US 21 / US 178 / US 601 Truck (Joe S. Jeffords Highway) – Charleston, North, Columbia | |
| Orangeburg | ​ | 65.910 | 106.072 | | I-26 – Charleston, Columbia | I-26 exits 154 A-B |
| Orangeburg | ​ | 72.040 | 115.937 | | US 176 (Old State Road) – Holly Hill, Cameron | |
| Orangeburg | ​ | 72.560 | 116.774 | | SC 47 east (Cleveland Street) – Elloree | Western terminus of SC 47; to Santee State Park |
| Orangeburg | ​ | 78.020 | 125.561 | | SC 267 (Tee Vee Road) – Holly Hill, Elloree | |
| Orangeburg | ​ | 79.620 | 128.136 | | US 15 south / US 15 Conn. north (Bass Drive) – St. George, Santee, Santee State Park | Southern end of US 15 concurrency; southern terminus of US 15 Conn.; SCHP Patrolman Harry B. Ray Memorial Intersection |
| Orangeburg | ​ | 80.608– 80.947 | 129.726– 130.272 | | I-95 south / Five Chop Road east (SC 6 Conn. east) – Savannah | Southern end of I-95 concurrency; western terminus of SC 6 Conn. and Five Chop Road; I-95 exit 97; northbound exit and southbound entrance |
| Orangeburg | ​ | 82.632 | 132.983 | 98 | SC 6 – Eutawville, Santee, Elloree | Exit number follows I-95 |
| Lake Marion | Lake Marion | 84.442– 84.448 | 135.896– 135.906 | Williams James Gooding Bridge | Williams James Gooding Bridge | Williams James Gooding Bridge |
| Clarendon | ​ | 86.273– 86.312 | 138.843– 138.906 | | I-95 north – Florence | Northern end of I-95 concurrency; I-95 exit 102; northbound entrance and southbound exit |
| Clarendon | Summerton | 93.712 | 150.815 | | US 15 north (Church Street) – Sumter | Northern end of US 15 concurrency |
| Clarendon | Summerton | 93.777 | 150.919 | | Railroad Avenue west (US 15 Conn. north) | Southern terminus of US 15 Conn.; eastern terminus of Railroad Avenue |
| Clarendon | ​ | 99.162 | 159.586 | | I-95 – Savannah, Florence | I-95 exit 115 |
| Clarendon | Manning | 103.872 | 167.166 | | SC 260 (Mill Street) – Jordan | To Santee Dam |
| Clarendon | Manning | 104.222 | 167.729 | | SC 261 (Boyce Street) to US 521 – Kingstree, Georgetown, Columbia | |
| Clarendon | Manning | 104.962 | 168.920 | | US 521 south (Church Street) – Georgetown | Southern end of US 521 concurrency |
| Clarendon | ​ | 106.282 | 171.044 | | US 521 north – Sumter | Northern end of US 521 concurrency |
| Clarendon | ​ | 107.822 | 173.523 | | Trinity Church Road west (US 301 Conn. north) – Alcolu | Southern terminus of US 301 Conn.; eastern terminus of Trinity Church Road |
| Clarendon | Sardinia | 116.382 | 187.299 | | SC 527 (Black River Road) – Kingstree, Sumter | |
| Clarendon | Turbeville | 122.302 | 196.826 | | US 378 west (Clarence Coker Highway) – Sumter | Southern end of US 378 concurrency |
| Clarendon | Turbeville | 122.402 | 196.987 | | SC 58 north (Gamble Street) – Lynchburg, Bishopville | Southern terminus of SC 58 |
| Clarendon | Turbeville | 123.022 | 197.985 | | US 378 east – Lake City, Conway, Myrtle Beach | Northern end of US 378 concurrency |
| Florence | Olanta | 128.752 | 207.206 | | SC 341 (Hampton Street) – Lake City, Lynchburg, Timmonsville, Bishopville | To Woods Bay State Natural Area |
| Florence | Kelley Crossroads | 132.122 | 212.630 | | SC 403 (Bethel Road) – Lake City | |
| Florence | Effingham | 142.772 | 229.769 | | US 52 south / SC 327 north – Lake City | Southern end of US 52 concurrency; southern terminus of SC 327 |
| Florence | Florence | 148.622 | 239.184 | | US 52 north / US 52 Truck begins – Florence | Northern end of US 52 concurrency; southern end of US 52 Truck concurrency; southern terminus of US 52 Truck |
| Florence | Florence | 149.892 | 241.228 | | US 52 Truck north (South Church Street) to US 52 – Darlington | Northern end of US 52 Truck concurrency |
| Florence | Florence | 150.162 | 241.662 | | SC 51 (Pamplico Highway) – Pamplico | |
| Florence | ​ | 156.112 | 251.238 | | US 76 west (Marion Highway) / SC 327 north (Williston Road) to I-20 / I-95 – Florence | Southern end of US 76/SC 327 concurrency |
| Florence | Mars Bluff | 157.802 | 253.958 | | SC 327 south (Francis Marion Road) – Pamplico | Southern end of SC 327 concurrency |
| Great Pee Dee River | Great Pee Dee River | | | | David Walker Harwell Bridge | David Walker Harwell Bridge |
| Marion | Pee Dee | 164.942 | 265.448 | | US 76 east – Marion, Myrtle Beach | Partial interchange; northern end of US 76 concurrency |
| Dillon | ​ | 173.102– 173.122 | 278.581– 278.613 | | SC 38 – Marion, Bennettsville | Interchange |
| Dillon | Latta | 175.425 | 282.319 | | US 501 south – Marion, Myrtle Beach | Southern end of US 501 concurrency |
| Dillon | Latta | 176.184 | 283.541 | | SC 917 (Main Street) – Mullins, Bennettsville | |
| Dillon | Dillon | 182.764 | 294.130 | | SC 9 south / SC 34 west / SC 57 south (Main Street) – Lake View, North Myrtle Beach | Southern end of SC 9/SC 57 concurrency; eastern terminus of SC 34 |
| Dillon | Dillon | 183.704 | 295.643 | | SC 9 north / SC 57 north (Radford Boulevard) – Bennettsville, Charlotte | Northern end of SC 9/SC 57 concurrency |
| South Carolina–North Carolina line | South Carolina–North Carolina line | 189.704 | 305.299 | | I-95 – Florence, Fayetteville, Lumberton | I-95 exit 1 |
| South Carolina–North Carolina line | South Carolina–North Carolina line | 189.704 | 305.299 | | US 301 north / US 501 north | Continuation into North Carolina |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus |||||||