# List of Billboard Mainstream Top 40 number-one songs of 2001

This is a list of songs which topped the Billboard Mainstream Top 40 chart in 2001.
During 2001, a total of 14 singles hit number-one on the charts.
* The best-performing song of 2001, "Hanging by a Moment" by Lifehouse, never reached #1 on the weekly charts.
| Issue date | Song | Artist(s) |
| January 6 | "Independent Women Part I" | Destiny's Child |
| January 13 | "It Wasn't Me" | Shaggy featuring Rikrok |
| January 20 | "It Wasn't Me" | Shaggy featuring Rikrok |
| January 27 | "Independent Women Part I" | Destiny's Child |
| February 3 | "Independent Women Part I" | Destiny's Child |
| February 10 | "Again" | Lenny Kravitz |
| February 17 | "Again" | Lenny Kravitz |
| February 24 | "Love Don't Cost a Thing" | Jennifer Lopez |
| March 3 | "Again" | Lenny Kravitz |
| March 10 | "Angel" | Shaggy featuring Rayvon |
| March 17 | "Angel" | Shaggy featuring Rayvon |
| March 24 | "Angel" | Shaggy featuring Rayvon |
| March 31 | "Angel" | Shaggy featuring Rayvon |
| April 7 | "Angel" | Shaggy featuring Rayvon |
| April 14 | "Angel" | Shaggy featuring Rayvon |
| April 21 | "Angel" | Shaggy featuring Rayvon |
| April 28 | "Angel" | Shaggy featuring Rayvon |
| May 5 | "All for You" | Janet Jackson |
| May 12 | "All for You" | Janet Jackson |
| May 19 | "All for You" | Janet Jackson |
| May 26 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| June 2 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| June 9 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| June 16 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| June 23 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| June 30 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| July 7 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| July 14 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| July 21 | "Lady Marmalade" | Christina Aguilera, Lil' Kim, Mýa, and P!nk |
| July 28 | "All or Nothing" | O-Town |
| August 4 | "All or Nothing" | O-Town |
| August 11 | "All or Nothing" | O-Town |
| August 18 | "All or Nothing" | O-Town |
| August 25 | "Let Me Blow Ya Mind" | Eve featuring Gwen Stefani |
| September 1 | "Hit 'em Up Style (Oops!)" | Blu Cantrell |
| September 8 | "Hit 'em Up Style (Oops!)" | Blu Cantrell |
| September 15 | "Hit 'em Up Style (Oops!)" | Blu Cantrell |
| September 22 | "Hit 'em Up Style (Oops!)" | Blu Cantrell |
| September 29 | "Hit 'em Up Style (Oops!)" | Blu Cantrell |
| October 6 | "Fallin'" | Alicia Keys |
| October 13 | "Fallin'" | Alicia Keys |
| October 20 | "Fallin'" | Alicia Keys |
| October 27 | "Fallin'" | Alicia Keys |
| November 3 | "Fallin'" | Alicia Keys |
| November 10 | "I'm Real" | Jennifer Lopez featuring Ja Rule |
| November 17 | "I'm Real" | Jennifer Lopez featuring Ja Rule |
| November 24 | "Family Affair" | Mary J. Blige |
| December 1 | "Family Affair" | Mary J. Blige |
| December 8 | "Family Affair" | Mary J. Blige |
| December 15 | "Family Affair" | Mary J. Blige |
| December 22 | "How You Remind Me" | Nickelback |
| December 29 | "How You Remind Me" | Nickelback |