# 2023 Open Città della Disfida – Singles

Nuno Borges was the defending champion but chose not to defend his title.
Shintaro Mochizuki won the title after defeating Santiago Rodríguez Taverna 6–1, 6–4 in the final.

## Seeds

* Alexander Shevchenko (first round)
* Filip Misolic (first round)
* Franco Agamenone (semifinals)
* Benoît Paire (first round)
* Francesco Maestrelli (first round)
* Laurent Lokoli (quarterfinals)
* Zdeněk Kolář (second round)
* Flavio Cobolli (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final |
| | Shintaro Mochizuki | 6 | 5 | 6 | | | |
| 3 | Franco Agamenone | 4 | 7 | 2 | | | |
| 3 | Franco Agamenone | 4 | 7 | 2 | Shintaro Mochizuki | 6 | 6 |
| | | | | | Santiago Rodríguez Taverna | 1 | 4 |
| | Santiago Rodríguez Taverna | 6 | 6 | | Santiago Rodríguez Taverna | 1 | 4 |
| | Nicholas David Ionel | 4 | 4 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | A Shevchenko | 3 | 7 | 4 | | | | | | | | | | | | | | |
| | JB Torres | 6 | 5 | 6 | | JB Torres | 2 | 5 | | | | | | | | | | |
| WC | F Arnaboldi | 2 | 3 | | | S Mochizuki | 6 | 7 | | | | | | | | | | |
| | S Mochizuki | 6 | 6 | | | | | | | | S Mochizuki | 6 | 6 | | | | | |
| | Z Piros | 3 | 6 | 6 | | | | | | | Z Piros | 4 | 1 | | | | | |
| Q | Edoardo Lavagno | 6 | 1 | 3 | | Z Piros | 3 | 6 | 6 | | | | | | | | | |
| Q | J Ocleppo | 6$^3$ | 6 | 2 | 7 | Z Kolář | 6 | 3 | 2 | | | | | | | | | |
| 7 | Z Kolář | 7$^7$ | 2 | 6 | | | | | | | | | | | S Mochizuki | 6 | 5 | 6 |
| 3 | F Agamenone | 6 | 6 | | | | | | | | | | | 3 | F Agamenone | 4 | 7 | 2 |
| Alt | J McCabe | 0 | 1 | | 3 | F Agamenone | 3 | | | | | | | | | | | |
| | M Zekić | 6 | 1 | 6$^7$ | | M Gigante | 2$^r$ | | | | | | | | | | | |
| | M Gigante | 3 | 6 | 7$^9$ | | | | | | 3 | F Agamenone | 7 | 6 | | | | | |
| | T Droguet | 7$^7$ | 7$^7$ | | | | | | | 6 | L Lokoli | 5 | 2 | | | | | |
| Q | S Napolitano | 6$^4$ | 6$^2$ | | | T Droguet | 6 | 5 | 4 | | | | | | | | | |
| WC | G Mager | 6$^4$ | 3 | | 6 | L Lokoli | 4 | 7 | 6 | | | | | | | | | |
| 6 | L Lokoli | 7$^7$ | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| 5 | F Maestrelli | 3 | 0 | | | | | | | | | | | |
| | A Pellegrino | 6 | 6 | | | A Pellegrino | 6 | 6 | | | | | | |
| Q | S Travaglia | 7$^{12}$ | 6 | | Q | S Travaglia | 2 | 2 | | | | | | |
| | N Serdarušić | 6$^{10}$ | 3 | | | | | | A Pellegrino | 3 | 5 | | | |
| | D Sweeny | 1 | 6$^4$ | | | | | | S Rodríguez Taverna | 6 | 7 | | | |
| Q | J Berrettini | 6 | 7$^7$ | | Q | J Berrettini | 2 | 2 | | | | | | |
| | S Rodríguez Taverna | 6 | 4 | 6 | | S Rodríguez Taverna | 6 | 6 | | | | | | |
| 4 | B Paire | 2 | 6 | 4 | | | | | | | | S Rodríguez Taverna | 6 | 6 |
| 8/WC | F Cobolli | 4 | 6$^1$ | | | | | | | | | ND Ionel | 4 | 4 |
| LL | S Caruso | 6 | 7$^7$ | | LL | S Caruso | 2 | 4 | | | | | | |
| | S Diez | 7$^7$ | 6 | | | S Diez | 6 | 6 | | | | | | |
| | FC Jianu | 6$^5$ | 1 | | | | | | S Diez | 1 | 2 | | | |
| Q | Gabriele Piraino | 4 | 6 | 3 | | | | | ND Ionel | 6 | 6 | | | |
| | ND Ionel | 6 | 4 | 6 | | ND Ionel | 6 | 6 | | | | | | |
| | M Navone | 7 | 7 | | | M Navone | 1 | 4 | | | | | | |
| 2 | F Misolic | 5 | 5 | | | | | | | | | | | |