OpenLLM-France/wikimedia huggingface dataset:
# Dose-ranging study

A dose-ranging study is a clinical trial where different doses of an agent (e.g. a drug) are tested against each other to establish which dose works best and/or is least harmful.
Dose-ranging is usually a pre-clinical, phase I or early phase II clinical trial. Typically a dose ranging study will include a placebo group of subjects, and a few groups that receive different doses of the test drug. For instance, a typical dose-ranging study may include four groups: a placebo group, low-dose group, medium-dose group and a high-dose group. The maximum tolerable dose (MTD) information is necessary to be able to design such groups and therefore dose-ranging studies are usually designed after the availability of MTD information.
The main goal of a dose-ranging study is to estimate the response vs. dose given, so as to analyze the efficacy and safety of the drug. Although such a response will nevertheless be available from phase III or phase IV trials, it is important to carry out dose-ranging studies in the earlier phase I or phase II stages. There are advantages to using healthy volunteers. They are in a steady-state condition showing no different stages of disease and no variation due to disease. In addition, it is easy to recruit and select volunteers among varying age, sex, race etc. under identical conditions in which the test can be repeated. The main reasons for this is to avoid trials in the later phases using doses that are significantly different from those that will subsequently be recommended for clinical use and also to avoid the need for modification of dosing schedules at later stages where a large amount of data has already been accumulated for a different dose range. The duration of action should be determined during dose-ranging study, as it will allow definition of the dosage schedule. Because it is hard to measure reliable pharmacodynamic parameter, it is difficult to determine the duration of action during early clinical trials. Other parameters instead are suggested as a tentative dosage, such as half-lives in plasma and urine in various test species and human, receptor binding in vitro, or pharmacodynamic data in vivo in animals.
# WOCA

WOCA (1370 AM, 96.3 FM) is a commercial radio station in Ocala, Florida. WOCA broadcasts a variety of syndicated and conservative-leaning programs, including The Glenn Beck Program each weekday. The station also produces shows for a number of local commentators.

## History

WOCA signed on as WHYS on November 19, 1957. In 1959, the call letters were changed to WKOS. In 1965, the station adopted a Top 40 format as WWKE. The station then switched to the current calls, WOCA in 1983.
# Johnny Thomsen

Johnny Juul Thomsen (born 26 February 1982) is a Danish football midfielder who plays for Danish amateur club Fredericia KFUM.
Before this he played in F.C. Copenhagen, SønderjyskE and FC Fredericia. Thomsen has gained 3 caps for the Danish national team.

## Career

Johnny played his first match with F.C. Copenhagen against his former club SønderjyskE.
In the start of 2012 he was released from his contract in Copenhagen and signed a new 4 year long contract with Randers FC.
After a long career, Thomsen decided to retire from professional football and in June 2021, he re-joined the club where it all began, Fredericia KFUM.
# Engagement between the United States and the Macedonian

Engagement between the United States and the Macedonian is an 1813 oil painting by American painter Thomas Birch depicting the naval engagement fought near Madeira on October 25, 1812 between the US Navy heavy frigate USS United States and the Royal Navy frigate HMS Macedonian. The battle resulted in the capture of the Macedonian, which became the first British warship to be brought to an American harbour as a prize.
Birch painted the subject at least three times. An original painting was displayed in the Oval Office at the White House from 1961 to 1963 during the presidency of John F. Kennedy. Kennedy made plans to redecorate the Oval Office after his inauguration in 1961, and he wanted a painting of a naval battle to hang over the fireplace. A report in The Philadelphia Inquirer led J. Welles Henderson (the lawyer, and son of Joseph Welles Henderson) to lend a painting of the engagement between the United States and the Macedonian and a second naval painting by Birch, which were part of his personal collection displayed at Philadelphia Maritime Museum. The other painting depicted the earlier battle of USS Constitution against HMS Guerriere. HMS Guerriere was captured in August 1812, but was too damaged and could not be brought back to port, so was set on fire and abandoned.
The work measures 62.9 cm × 81.9 cm (24.8 in × 32.2 in). After being displayed at the White House, it was held at museums in Philadelphia. It was sold by the estate of J. Welles Henderson at auction at Sotheby's in May 2008 for $481,000.
A slightly different and slightly larger version, which measures 70.48 cm × 91.1 cm (27.75 in × 35.87 in), also attributed to Birch 1813, has been held by the Museum of Fine Arts, Boston, since 1978. A third version, which measures 28 in × 34.5 in (71 cm × 88 cm), also Birch 1813, is held by the Historical Society of Pennsylvania.
A version by or after Birch is at the Home of Franklin D. Roosevelt National Historic Site, in Hyde Park, New York; and a version 25 in × 30 in (64 cm × 76 cm) "After Thomas Birch" was sold at Christie's in 2017 for $11,250.
An engraving of the painting by Benjamin Tanner was published on 25 October 1813. Another engraving was made by Samuel Seymour, 1815, and published by James Webster.
# Francisco Rodríguez (Swiss footballer)

Francisco José Rodríguez Araya (born 8 February 1995) is a Swiss professional footballer who plays as a midfielder. His older brothers are the Swiss international Ricardo Rodríguez and the winger Roberto Rodríguez.

## Club career
### FC Zürich

Rodríguez is a youth exponent from FC Zürich. He made his Swiss Super League debut on 20 July 2014 in the derby against Grasshopper Club Zürich, playing the entirety of a 1–0 win.

### VfL Wolfsburg

After a year with his first senior side, Rodríguez joined his brother Ricardo at German side VfL Wolfsburg signing a three-year contract until 2018. The transfer fee was believed to be €1.6 million. He received his first call for the senior team on 26 September 2015, when he was an unused substitute in a Bundesliga match versus Hannover 96.
He was loaned to Arminia Bielefeld on 22 January 2016. On 31 August 2016, the loan deal with Bielefeld was terminated and Rodríguez joined FC Luzern.

### FC Luzern

In June 2017, it was confirmed that Rodriguez had transferred to FC Luzern for an undisclosed fee.

## International career

Rodríguez is a Swiss under-19 international who is eligible to play for Chile or Spain through his parents' nationality. On 18 August 2014, manager Jorge Sampaoli called Rodríguez to play for Chile in two friendlies against Mexico and Haiti, and he was set to make his full international debut. But on 21 August 2015, he refused the call up to the senior squad for a match against Paraguay, saying that he still preferred to play for Switzerland's U21 team.
# Kūdra

Kūdra is a residential area and neighbourhood of the city Jūrmala, Latvia.
The Kūdra railway station was established in 1951.
# Gaston Rebry

Gaston Rebry (29 January 1905 – 3 July 1953) was a Belgian former champion road racing cyclist between 1928 and 1935.
In 1934, Rebry became the third of nine riders to win the Tour of Flanders and Paris–Roubaix in the same year; he also won Paris–Nice that year. Rebry won Paris–Roubaix three times. He also won four stages of the Tour de France.
His son, Gaston Rebry (1933–2007), was also a road-racing cyclist in the 1950s but moved to Canada in 1954 to become a landscape painter. He died on 5 January 2007.

## Major results
### 1926

    3rd, Paris–Roubaix

### 1928

    12th, Overall, Tour de France
       1st, Stage 3, (Cherbourg - Dinan)

### 1929

    10th, Overall, Tour de France
       yellow jersey as leader of the general classification after stage 8
       1st, Stage 14, (Nice - Grenoble)

### 1931

    1st, Paris–Roubaix
    4th, Overall, Tour de France
       1st, Stage 23, (Charleville - Malo les Bains, 271 km)

### 1932

    20th, Overall, Tour de France
       1st, Stage 19, (Charleville - Malo les Bains, 271 km)

### 1933

    14th, Overall, Tour de France

### 1934

    1st, Paris–Roubaix
    1st, Tour of Flanders
    1st, Paris–Nice

### 1935

    1st, Paris–Roubaix
# WODZ-FM

WODZ-FM (96.1 MHz), branded as "The Eagle", is a radio station broadcasting a classic hits format. Licensed to Rome, New York, United States, the station serves the Utica–Rome market. The station is owned by Townsquare Media as part of a cluster with news-talk station WIBX, classic rock-formatted WOUR, hot AC-formatted WLZW (Lite 98.7), and country-formatted WFRG (Big Frog 104).

## History

WODZ-FM signed on in August 1968 as WKAL-FM, owned by Maurer Broadcasting Corporation and operating at 95.9 FM. The station originally simulcast its AM sister station, WKAL (1450 AM). In 1977, WKAL-FM dropped the simulcast in favor of beautiful music.
Maurer Broadcasting Corporation sold WKAL AM-FM to Wooster Republican Publishing Company of Wooster, Ohio in 1980. In July 1984, WKAL-FM changed its call letters to WTCO, and became a country music station, "Top Country." The following year, the station, along with WKAL, was acquired by Howard Green and Donald Simmons, owner of WENY AM-TV and WLEZ in Elmira and WOND and WMGM FM-TV in Atlantic City, New Jersey. The new owners reverted the station's call letters to WKAL-FM on February 10, 1986, and implemented a soft adult contemporary format.
Target Communications bought WKAL AM-FM from Green and Simmons in 1987; soon after taking over, on February 1, 1988, the call sign was changed to WFRG-FM, and the station returned to country music, this time branded "96 Frog". The new format was simulcast on 1450 AM, which also took the WFRG call letters (save for a short time in the early 1990s when the AM station broke away to become oldies station WZLB); in addition, the station moved to its current frequency, 96.1. Target Communications eventually became Arrow Communications, which went into receivership in 1992, and then in November 1993, WFRG AM-FM was purchased by Forever Broadcasting, owners of WIBX and dominant market leader WLZW. Forever renamed the stations WODZ and launched an oldies format, with the country format and WFRG-FM call letters moving to 104.3 FM. The simulcast on AM 1450 continued until May 1999, when that frequency was sold to the Bible Broadcasting Network and became WYFY (it has since reclaimed the WKAL call sign). Forever sold its stations in the market, including WODZ-FM, to Regent Communications (the forerunner to Townsquare Media) several months later. On January 2, 2015, WODZ shifted to classic hits and rebranded from "Oldiez 96" to "96.1 The Eagle."
# Bill Anderson (American football, born 1925)

Billy Joe Anderson (July 20, 1925 – February 20, 2013) was an American football player and coach. He served as the head football coach at Howard Payne University from 1988 to 1991, compiling a record of 24–18. Anderson was also the head football coach at Cisco Junior College—now known as Cisco College—in Cisco, Texas and at three high schools in the state of Texas: Stamford High School from 1967 to 1968 and 1974 to 1976, Graham High School in 1977, and Westwood High School in Palestine for one season, in 1977.

## Early life, military service, and playing career

Anderson was born in Erath County, Texas, on July 20, 1925. During World War II, he trained as B-29 tail gunner in the United States Army Air Forces, but did not serve overseas. After the war, he attended Pepperdine University, where he played college football from 1947 to 1949 before graduating in 1950.

## Coaching career

Anderson was an assistant coach at Stamford High School in Stamford, Texas for 14 years before succeeding Larry Wartes in head football coach in 1967. After working as an assistant football coach at Abilene Christian University for two seasons, Anderson was hired, in 1971, as head coach football coach at Graham High School, in Graham, Texas, succeeding Darrell Williams. He was an assistant coach at Cisco Junior College—now known as Cisco College—in Cisco, Texas, in 1973, and then returned to Stamford High School as head football coach in 1974. After three more seasons at Stamford, he spent the 1977 season as head football coach at Westwood High School in Palestine before returning to Cisco Junior College in 1978. Anderson went to Howard Payne University in 1984 as offensive coordinator. He was the offensive coordinator at Tarleton State University from 1986 to 1987 before returning to Howard Payne as head football coach in 1988.

## Death

Anderson died on February 20, 2013, in Brownwood, Texas.

## Head coaching record
### College

| Year | Team | Overall | Conference | Standing |
| Howard Payne Yellow Jackets (Texas Intercollegiate Athletic Association) (1988–1991) ||||||
| 1988 | Howard Payne | 4–7 | 4–6 | T–4th |
| 1989 | Howard Payne | 8–3 | 8–2 | T–1st |
| 1990 | Howard Payne | 5–5 | 3–3 | T–3rd |
| 1991 | Howard Payne | 7–3 | 3–2 | T–2nd |
| Howard Payne: | Howard Payne: | 24–18 | 18–13 | |
| Total: | Total: | 24–18 | | |
| National championship  Conference title  Conference division title or championship game berth ||||||
# Frank Benatelli

Frank Benatelli (born 19 August 1962) is a German football coach and a retired player.

## Career

Born and raised in Bochum, Benatelli played in his youth for the local clubs SV Waldesrand Linden and SV Westfalia Weitmar 09. Still during his youth career, he joined local heavyweights VfL Bochum, where he made it into the first team and spent his entire senior career.
He had to retire at the age of only 28 due to an injury of his patellar ligament which resulted in a limited capacity of his knee.

## Personal life

He is the son of a German mother and an Italian father, Egidio, who hails from Caorle close to Venice. He himself has two children, a daughter, Laura, and a son, Rico, who is also a professional footballer.

## Career statistics

Appearances and goals by club, season and competition :
| Club | Season | League | League | League | DFB-Pokal | DFB-Pokal | Total | Total |
| Club | Season | Division | Apps | Goals | Apps | Goals | Apps | Goals |
| VfL Bochum II | 1981–82 | Verbandsliga Westfalen | | | — | — | | |
| VfL Bochum II | 1982–83 | Oberliga Westfalen | | | — | — | | |
| VfL Bochum II | Total | Total | | | 0 | 0 | | |
| VfL Bochum | 1982–83 | Bundesliga | 8 | 0 | 0 | 0 | 8 | 0 |
| VfL Bochum | 1983–84 | Bundesliga | 15 | 1 | 0 | 0 | 15 | 1 |
| VfL Bochum | 1984–85 | Bundesliga | 15 | 4 | 0 | 0 | 15 | 4 |
| VfL Bochum | 1985–86 | Bundesliga | 27 | 4 | 5 | 1 | 32 | 5 |
| VfL Bochum | 1986–87 | Bundesliga | 30 | 1 | 0 | 0 | 30 | 1 |
| VfL Bochum | 1987–88 | Bundesliga | 15 | 0 | 5 | 0 | 20 | 0 |
| VfL Bochum | 1988–89 | Bundesliga | 30 | 0 | 2 | 0 | 32 | 0 |
| VfL Bochum | 1989–90 | Bundesliga | 28 | 1 | 2 | 0 | 30 | 1 |
| VfL Bochum | 1990–91 | Bundesliga | 5 | 0 | 0 | 0 | 5 | 0 |
| VfL Bochum | 1991–92 | Bundesliga | 19 | 2 | 0 | 0 | 19 | 2 |
| VfL Bochum | Total | Total | 192 | 13 | 14 | 1 | 206 | 14 |
| Career total | Career total | Career total | 192 | 13 | 14 | 1 | 206 | 14 |

## Honours

VfL Bochum
* DFB-Pokal finalist: 1987–88
# Bohutín (Příbram District)

Bohutín is a municipality and village in Příbram District in the Central Bohemian Region of the Czech Republic. It has about 2,000 inhabitants.

## Administrative division

Bohutín consists of four municipal parts (in brackets population according to the 2021 census):
* Bohutín (558)
* Havírna (155)
* Tisová (139)
* Vysoká Pec (890)

## Etymology

The name is derived from the personal Bohuta, meaning "Bohuta's (court)".

## Geography

Bohutín is located about 4 kilometres (2 mi) southwest of Příbram and 52 km (32 mi) southwest of Prague. It lies in the Brdy Highlands. The highest point is the hill Leč at 628 m (2,060 ft). The Litavka River flows through the municipality. There are two notable fishponds: Vysokopecký and Vokačovský.

## History

The first written mention of Bohutín is from 1379. Historically, it is a mining settlement associated with the mining of lead and silver ore.

## Demographics

| Year | Pop. | ±% |
| 1869 | 1,610 | — |
| 1880 | 1,835 | +14.0% |
| 1890 | 2,061 | +12.3% |
| 1900 | 2,188 | +6.2% |
| 1910 | 1,822 | −16.7% |
| Year | Pop. | ±% |
| 1921 | 1,480 | −18.8% |
| 1930 | 1,339 | −9.5% |
| 1950 | 991 | −26.0% |
| 1961 | 1,399 | +41.2% |
| 1970 | 1,296 | −7.4% |
| Year | Pop. | ±% |
| 1980 | 1,344 | +3.7% |
| 1991 | 1,397 | +3.9% |
| 2001 | 1,487 | +6.4% |
| 2011 | 1,630 | +9.6% |
| 2021 | 1,742 | +6.9% |
Source: Censuses :

## Transport

The I/18 road (the section from Příbram to Rožmitál pod Třemšínem) passes through the municipality.

## Sights

The main landmark of the Bohutín is the Church of the Saint Mary Magdalene. The original church from 1887 was destroyed by a fire in 1950, then it was again built in the pseudo-Gothic style.
In Vysoká Pec is a museum dedicated to Bohutín and its surroundings. Next to the museum is Řimbaba, a former mining tower converted into a lookout tower. The viewing platform of the observation tower is at a height of 14 m (46 ft).
# Cool Blue

Cool Blue is a 1989 American romantic comedy film directed by Mark Mullin and Richard Shepard, and stars Woody Harrelson, Hank Azaria, Ely Pouget and Sean Penn.

## Plot

An aspiring painter named Dustin Pennett is on a search for love, sex, and inspiration when he meets a woman named Christiane at an art gallery. They spend the night together at her apartment, but the next morning she has disappeared, leaving Dustin heartbroken. He visits her family home in Southern California and learns from her younger sister that Christiane ran away at a young age after having an abortion, also finding out that "Christiane's" apartment was actually a display room she had broken them into.
Dustin returns home to Los Angeles and, after confiding in Phil, a plumber who has seen Dustin at his local pub, about his issues with Christiane, finds success painting portraits of her from memory, idealizing her as his true love. Dustin's best friend, a struggling writer named Buzz, envies his friend's newfound success. After Dustin easily beds Cathy, a woman Buzz has been chasing for two years, Buzz angrily shouts at Dustin and threatens him with a pool cue during a drunken argument.
Christiane returns to the gallery and finds Dustin's paintings of her, including a nude one which she slashes. She then breaks into his apartment and throws blue paint on him. Christiane says that they had a meaningless encounter and complains that the paintings are interfering with her life. Dustin responds that he painted them because their night together meant something to him and he wants to get to know her as a person.
After making up with Buzz, Dustin ditches a show planned for him in New York by his manager Paul in order to meet Christiane at the Los Angeles County Museum of Art. The film ends with a shot of Dustin and Christiane embracing.

## Cast

* Woody Harrelson as Dustin
* Hank Azaria as "Buzz"
* Ely Pouget as Christiane
* Paul Lussier as Paul
* Phillip Brock as Bruce
* Judie Aronson as Cathy
* Christopher McDonald as Peter Sin
* Gloria LeRoy as Ida
* Karen Haber as Sascha
* Jonathan Chapin as Les
* Cindy Guyer as Girl In Gallery
* Elisabeth Mullin as Rebecca
* Allison Robinson as Cindy
* Brian Ruf as The Bartender
* Nicoletta Munroe as Anna
* John Diehl as Clayton
* Julie Friedman
* Sean Penn as Phil, The Plumber (uncredited)

## Home media

Filmed in mid-1988 in Los Angeles, Cool Blue was picked up for domestic distribution by RCA-Columbia and Epic Home Video in late 1989. It was first released in the US on February 27, 1990, on pay-per-view and cable TV. On March 7, it was released in the US on VHS and LaserDisc, however it was first released in Greece on VHS in September 1989. In 1991, the film was released on VHS in Australia and the UK.
It was not released on DVD until March 13, 2012, when MGM Home Entertainment released a remastered widescreen version as part of their Limited Edition Collection, with a trailer as the only special feature.
# Joseph Lubin (entrepreneur)

Joseph Lubin (born 1964) is a Canadian-American businessman. He has founded and co-founded several companies, including the Swiss-based EthSuisse, contributing heavily to Ethereum, the decentralized cryptocurrency platform. Lubin is the founder of ConsenSys, a Brooklyn-based software production studio.
In February 2018, Forbes estimated Lubin's net worth in cryptocurrency to be between one and five billion dollars.

## Career

In early 2014, Lubin was a co-founder of Ethereum and served as chief operating officer of Ethereum Switzerland GmbH (EthSuisse), a company working to extend the capabilities of the type of blockchain technology first popularized by Bitcoin, and extend the capabilities of the blockchain to store programs in addition to data, as well as facilitate, verify, or enforce the negotiation or performance of smart contracts. The new generation of distributed crypto-secure databases with smart contract functionality has been referred to as "Blockchain 2.0".
Lubin was also involved in the creation of the Ethereum Foundation.
He subsequently founded ConsenSys in 2015, a decentralized blockchain production studio. It develops software mainly for the Ethereum blockchain system. It also provides decentralized software services to companies. They also do enterprise and government consulting.
Lubin has been personally involved in cross-industry groups attempting to advance solutions to governance issues in the blockchain industry.
Lubin graduated from Princeton University with a degree in Electrical Engineering and Computer Science and worked with Goldman Sachs. Lubin's roommate at Princeton was Michael Novogratz.
# WOLM

WOLM "Radio Maria" (for: Our Loving Mother) is a non-commercial FM broadcasting station at 88.1 mHz licensed to D'Iberville, Mississippi and serving the D'Iberville and Biloxi areas. Its founder "Friends of Radio Maria" (which in addition airs Italian language programming on the FM subcarrier of New York City station WKTU) was the group that acquired the construction permit and start-up of WOLM in addition to sister stations WHJM which is licensed in Anna, Ohio and WRMW 91.1 FM licensed in Peshtigo, Wisconsin. All these stations are now owned by (and licensed to) Radio Maria Inc.
WOLM began as a construction permit issued by the FCC in May 2007. It launched on the air May 27, 2010 just three days before the construction permit deadline date. It is now licensed. 88.1 FM is also the frequency of Radio Maria-owned WHHN in Hollidaysburg, Pennsylvania serving the Altoona area.
Upon its initial sign-on, WOLM initially was airing sample archived programming from Radio Maria until the network connection with originator KJMJ was established. This took place on Tuesday June 1, 2010 making WOLM a full-time repeater of originating station KJMJ 580 kHz in Alexandria, Louisiana. Also launched within the same time frame is WRMW 91.3 mHz in Peshtigo, Wisconsin serving the Sturgeon Bay - Door County region.
Radio Maria USA also streams from its website for listeners outside the WOLM signal area in addition to iPhone, BlackBerry and Android mobile phone devices through an app which can be downloaded from the same website.
A hip-hop collective based out of Washington DC, New York, New Jersey, and Germany. WOLM (World Of Light Media). Formed in 2008 by Shamir and Nyce.