OpenLLM-France/wikimedia huggingface dataset:
# 4-Chlorokynurenine

L-4-Chlorokynurenine (4-Cl-KYN; developmental code name AV-101) is an orally active small molecule prodrug of 7-chlorokynurenic acid, a NMDA receptor antagonist. It was investigated as a potential rapid-acting antidepressant.
AV-101 was discovered at Marion Merrell Dow and its biological activity was explored at University of Maryland. It underwent initial development at Artemis Neuroscience which was acquired by VistaGen in 2003. A phase II clinical trial failed to show any effect over placebo in alleviating treatment-resistant depression.

## Pharmacology

4-Chlorokynurenine penetrates the blood–brain barrier via the large neutral amino acid transporter 1. In the central nervous system it is converted to 7-chlorokynurenic acid by kynurenine aminotransferase in astrocytes.
Most of its therapeutic potential is believed to occur via 7-chlorokynurenic acid which inhibits the glycine co-agonist site of NMDA receptors.
Another metabolite, 4-chloro-3-hydroxy-anthranilic acid, inhibits the enzyme 3-hydroxyanthranilate oxidase, which provides a rationale for further testing in neurodegenerative diseases.

## Chemistry

4-Chlorokynurenine is prodrug of 7-chlorokynurenic acid (7-Cl-KYNA), which in turn is a halogenated derivative of L-kynurenine.

## History

Artemis Neuroscience was formed to develop work done by University of Maryland professor Robert Schwartz in collaboration with scientists at Marion Merrell Dow (which became part of Sanofi by way of Aventis); this work included AV-101.
VistaGen acquired AV-101 when it acquired Artemis in 2003.
VistaGen filed an Investigational New Drug application with the FDA for use of AV-101 in neuropathic pain in 2013.
In 2013, other NMDA receptor antagonists in clinical trials for depression included lanicemine, esketamine, and rapastinel, with lanicemine being the most advanced.

## Research

By 2013, AV-101 had successfully gone through two Phase I clinical trials. In 2016, a Phase II clinical trial was initiated to assess AV-101 in treatment-resistant major depression. The trial found no difference in treatment effects between AV-101 and placebo.
Preclinical studies in animal models suggested efficacy in treating neuropathic pain. AV-101 showed efficacy in an animal model of Huntington's disease and rapid-acting antidepressant effects similar to ketamine in behavioral models of depression in rodents.
# Walter Hely-Hutchinson

Sir Walter Francis Hely-Hutchinson GCMG PC (22 August 1849 – 23 September 1913) was an Anglo-Irish diplomat and colonial administrator.

## Background and education

Hely-Hutchinson was the second son of Richard Hely-Hutchinson, 4th Earl of Donoughmore. He was educated at Cheam School, Harrow and Trinity College, Cambridge.

## Career

Hely-Hutchinson was a barrister of the Inner Temple, 1877; Private Secretary to Sir Hercules Robinson, Governor of New South Wales; for Fiji Affairs, 1874; for New South Wales, 1875; Colonial Secretary of Barbadoes, 1877; Chief Secretary to the Government of Malta, 1883; Lieutenant-Governor of Malta between 1884 and 1889, as Governor and Commander-in-Chief of the Windward Islands between 1889 and 1893 and as Governor and Commander-in-Chief of Natal and Zululand between 1893 and 1901 and Special Commissioner for Amatongaland. While in Natal he inaugurated the system of Responsible Government in Natal, and completed the annexation of the Trans-Pongola Territories, which form an integral part of Zululand.
He was appointed Governor of the Cape Colony in 1901, during the height of the Second Boer War in South Africa, and was the last British governor until the post disappeared when the colony joined the Union of South Africa in 1910. He also acted as High Commissioner for Southern Africa in 1909 during the absence of Lord Selborne. Following the end of the Boer war in June 1902, he was among those responsible for introducing the peace settlement in the colony. In November–December 1902 he made a month long tour of the Malmesbury, Saldanha Bay, Piquetberg, Clanwilliam, and Ceres districts. The following month, he welcomed the British Colonial Secretary, Joseph Chamberlain, during his tour of South Africa.
Hely-Hutchinson was awarded the honorary degree of Doctor of Law (LL.D.) by the University of Edinburgh and was invested as a Knight Grand Cross of the Order of St. Michael and St. George. He was invested as a Privy Counsellor; thus he was styled The Rt. Hon.

## Family

Hely-Hutchinson married in 1881 May Justice, the daughter of Major-General William Clive Justice, CMG, commanding British troops in Ceylon. They had seven children:
* John Walter Hely Hutchinson b. 14 Jan 1882, d. 11 Sep 1955
* Violet La Vallette Hely Hutchinson b. 26 Jul 1883, d. 11 Dec 1883
* Christopher Douglas Hely Hutchinson b. 30 Jan 1885, d. 7 Nov 1958, earned the Military Cross during World War I and was president of the British South Africa Company
* Maurice Robert Hely Hutchinson b. 22 May 1887, d. 11 Feb 1961, Member of Parliament (MP) for Hastings
* Jocelyn Frederick Osbert Hely Hutchinson b. 17 Jul 1891, d. 18 Jan 1893
* Natalie Leila Margaret Hely Hutchinson b. 5 Aug 1894, d. 1981; married the archaeologist and administrator Gerard Mackworth Young.
* Christian Victor Noel Hope Hely Hutchinson b. 28 Dec 1901, d. 11 Mar 1947, composer and musician. He was discovered to be a child prodigy as a toddler when he could vocally mimic the notes his mother played on the piano.
# Yoshitaka Egawa

Yoshitaka Egawa (江川 嘉孝, Egawa Yoshitaka, 20 December 1942 – 26 December 2024) was a Japanese basketball player. He competed in the men's tournament at the 1964 Summer Olympics. Egawa died in Kisarazu on 26 December 2024, at the age of 82.
# Aaptos glutinans

Aaptos glutinans is a species of sea sponge belonging to the family Suberitidae. The species was described in 2011. It was found in the localities known as Fernando de Noronha and Atoll das Rocas (Piscina das Âncoras, Rocas Atoll) Rio Grande do Norte, Brazil.
# Emily Rose Epstein

Emily Rose Epstein is an American drummer. She is best known for her collaborations with the garage rock musicians Ty Segall and Mikal Cronin. She was a former member of Segall's live band, and a former member of Cronin's. She met Segall at the University of San Francisco.
Before becoming a drummer - she was influenced to be a writer like her grandfather - Emily went to college to become a journalist. Her grandfather influenced her with art journalism and with poetry as well. Emily started playing the drums at a young age. When she was 13, she played drums for a UCLA band. While she was on tour with Segall, she would continue college and continued in journalism and editing.
Emily Rose took a break from touring in 2015 to take her country band more seriously. In 2017 she reformed the band as the Blue Rose Rounders, now called Emily Rose & the Rounders.
She continues to tour with Emily Rose & the Rounders and has been a part of the touring and recording incarnation of Pink Mountaintops.

## Discography

With Ty Segall Band
* Slaughterhouse (2012)
* Live in San Francisco (2014)
# Bolívar Department

Bolívar (Spanish pronunciation:) is a department of Colombia. It was named after one of the original nine states of the United States of Colombia. It is located to the north of the country, extending roughly north–south from the Caribbean coast at Cartagena near the mouth of the Magdalena River, then south along the river to a border with Antioquia Department. The departments of Sucre and Córdoba are located to the west, and Atlántico Department to the north and east (most of the border formed by the Canal del Dique). Across the Magdalena River to the east is Magdalena Department. The flag of the department bears a resemblance to the flag of Lithuania.
Its capital is Cartagena de Indias. Other important cities include Magangué, El Carmen de Bolívar and Turbaco.

## History

In today's villages of Maria La Baja, Sincerín, El Viso, and Mahates and Rotinet, excavations have uncovered the remains of maloka-type buildings, directly related to the early Puerto Hormiga settlements.

## Miscellaneous

* Postage stamps of Bolívar
* List of Caribbean islands#Bolívar Department
# WKAM

WKAM 1460 AM is a radio station broadcasting a Regional Mexican music format. Licensed to Goshen, Indiana, the station is owned by I.B. Communications, LTD. The station also broadcasts on translator 98.1 W251AR licensed to Goshen, Indiana.

## History

WKAM was established in Warsaw, Indiana, with the awarding of a construction permit to Kosciusko Broadcasting Corporation for a 250-watt, daytime-only radio station on December 22, 1948. The station went on the air July 11, 1949, and remained in Warsaw until 1954, when it was approved to move to Goshen, change frequency to 1460 kHz, and increase power to 500 watts. The move to Goshen was in part because the city had no radio stations despite having a larger population than Warsaw, which was also served by WRSW.

## Translator

| Call sign | Frequency | City of license | FID | ERP (W) | HAAT | Class | Transmitter coordinates | FCC info |
| W251AR | 98.1 FM | Goshen, Indiana | 157025 | 13 | 101.8 m (334 ft) | D | 41°36′4.2″N 85°55′41″W﻿ / ﻿41.601167°N 85.92806°W﻿ / 41.601167; -85.92806﻿ (W251AR) | LMS |
# Goldasht-e Sofla

Goldasht-e Sofla (Persian: گلدشت سفلي, also Romanized as Goldasht-e Soflá; also known as Bondashlū Sarchasmeh, Bondashlū Sarcheshmeh, Gondashlū Sarchesmeh, Gondeshlū-ye Pā’īn, and Gondeshlū-ye Soflá) is a village in Majdabad Rural District, in the Central District of Marvdasht County, Fars province, Iran. At the 2006 census, its population was 195, in 43 families.
# Bill Wright (footballer, born 1914)

William Samuel Wright (born 1914) was an English professional footballer who played as a full-back.

## Career statistics

Source:
| Club | Division | Season | League | League | FA Cup | FA Cup | Total | Total |
| Club | Division | Season | Apps | Goals | Apps | Goals | Apps | Goals |
| Stoke City | First Division | 1934–35 | 0 | 0 | 0 | 0 | 0 | 0 |
| Port Vale | Third Division North | 1936–37 | 0 | 0 | 0 | 0 | 0 | 0 |
| Barrow | Third Division North | 1938–39 | 1 | 0 | 0 | 0 | 1 | 0 |
# Elko Tract

Elko Tract is a 2,220 acre (9km2) tract of land in Henrico County, Virginia. It is considered one of Virginia's ghost towns due to its history as a decoy airfield during World War II, then partially developed as an African-American mental hospital, before that project was abandoned.

## World War II

The history of the Tract prior to World War II is unremarkable. During the war, however, the area was converted into a false city, its structure closely resembling that of Richmond. Richmond sat nearby to the west of the tract. It is widely accepted that the premise behind the work was to serve as a decoy for German or Japanese bombers on night raids. In theory, when reports would come from the eastern Virginia cities that enemy bombers were flying overhead, the city would cut power to its residents and businesses. At the same time, the lights would come up on Elko Tract - roads built in roughly the same pattern as the city, and a false landing strip arranged identically to the nearby airport, would convince the bombers that they had reached their target. The bombs would then harmlessly fall on an uninhabited stretch of land, and the bombers would return, thinking they had successfully attacked Richmond.
World War II ended without any attempt by the Axis Powers to attack Richmond. Control of the land then passed to the Commonwealth of Virginia.
# Willard Beach

Willard Beach is a beach and neighborhood in South Portland, Maine. The beach, which covers 4 acres (1.6 ha), used for swimming as well as commercial and recreational boating. Southern Maine Community College abuts the beach. Willard Beach is known for its views of Spring Point Ledge Light as well as island forts including Fort Gorges.
WillardFest is an annual one day neighborhood festival which began in 2012.
# LaKemp, Oklahoma

LaKemp, also written as LaKEMP, Lakemp, and La Kemp, was a prosperous settlement in Beaver County, Oklahoma from 1909 to 1919. It was located approximately 5 to 7 miles north of present-day Booker, Texas. It terminated when the population left in mass for Booker.

## History

LaKemp was founded in 1909 by David L. Kemp, the principal owner and promoter of the town, and the person for whom the town was named. A 1911 Beaver County map shows LaKemp nestled among other ephemeral settlements of the era, including Pronto to the west, Sophia to the east, and Duckpond to the north-northeast, while the Texas border is placed close to its south.
The town was substantial. Over the course of its existence, it had two newspapers: the LaKemp Mirror, which ran from 1909 to about 1919, and The La Kemp Citizen, which ran from 1916 to about 1919. The town had a bank with over $100,000 in deposits, a hotel, blacksmith, dry goods store, drugstore, garage, café, and other available goods and services.
The town grew up on the premise that an Atchison, Topeka and Santa Fe Railway (“AT&SF”) affiliate was going to build a rail line west from Shattuck, Oklahoma through the area. The first edition of The Mirror states that the town had “…railroads and other commercial facilities knocking at her door….” But the AT&SF had other ideas: in 1916 it started buying up land in Lipscomb County, Texas for its line from Shattuck to Spearman, Texas, and in 1917 platted its own town of Booker in a location on that line about 5 to 7 miles south of LaKemp. However, World War I delayed actual construction of the line. So it was in 1919 that the citizens and businesses of LaKemp conducted a mass exodus to Booker, in some cases skidding whole buildings to the new location. The rail line was finally completed all the way to Spearman and opened for business July 1, 1920, as built by the North Texas and Santa Fe Railway and operated by the Panhandle and Santa Fe Railway.
Booker still survives as a town, population 1,437 as of the 2020 Census. But as to the rail line between Shattuck and Spearman, the Southwestern Railroad, by then operator of that trackage, received abandonment authority in 2007, and the route no longer appears on railroad maps.
# R. H. Chapman

Robert Hall Chapman (6 January 1890 – 10 May 1953) was an Australian engineer, Commissioner for Railways in South Australia from 1947 to 1950.

## History

Chapman was born son of Robert William Chapman and Eva Maude Chapman, née Knox, who married on 14 February 1889, and had a home on High Street, Burnside, South Australia. He was educated at St Peter's College and the University of Adelaide, where he had an outstanding academic career. He enlisted with the First AIF in August 1915, and after training at the NCO School at Mitcham served with the 12th Battalion in France, rising to rank of Captain, wounded in battle, then attached to the (British) 23rd Field Company, Royal Engineers, Calibration Section on Salisbury Plain.
He was appointed to the South Australian Railways as a civil engineer, and in 1923 was tasked with design and building of the railway bridge at Murray Bridge, after which he was appointed chief engineer for the State. He supervised the rebuilding of all railway bridges, station yards and locomotive depots, and the conversion of 220 miles (350 km) of track in the western division from narrow to broad gauge. He supervised the construction, during World War II, of the Finsbury munition works and the early stages of the Salisbury munitions factory.
He was made acting Railways Commissioner with the retirement of C. B. Anderson in 1946, then appointed to the substantive position on 16 January 1947, with a contracted term of seven years.
He died of a heart complaint in the (private) Ru Rua hospital a week after taking sick leave. His assistant, J. A. Fargher, was appointed his deputy while on leave, then Commissioner in October 1953.

## Recognition

Malcolm Mcintosh, Minister of Railways, described him as a "great administrator . . . His candid and cheerful manner endeared him to a vast number of friends, and his just administration earned him the esteem of every employe[e] of the railways".

## Other appointments

Chapman was the State Government appointee to the board of the Cellulose Company at Snuggery, between Tantanoola and Millicent. He relinquished that position when appointed Commissioner.

## Family

Chapman was engaged to Florence Muriel Day, but she married footballer Charlie Perry. He married May Warren "Maysie" Knox (c. 1899 – 11 November 1947) in 1923. Their children included:
* Maysie Hall Chapman (born 1924) married Dean Simes of Barmera on 26 July 1947
* Robert Charles Chapman (born 1928)
They had a home on West terrace, Kensington Gardens.
# Erasmo Fuentes

Erasmo Fuentes de Hoyos (born 1943) is a Mexican-born member of the Church of Jesus Christ of Latter-day Saints and sculptor who resides in Mapleton, Utah. Among his more well known works is "Anxiously Engaged" (made with his son Alex Fuentes) which is a 7-foot-tall (2.1 m) sculpture of Mormon missionaries on bikes; the sculpture is displayed at the Missionary Training Center in Provo, Utah.
Fuentes was born in Monterrey, Nuevo León, Mexico, but was raised in Saltillo, Mexico as a Latter-day Saint. He first came to the United States to work in 1964 and studied sculpture at Brigham Young University, graduating in 1968. He also was on the BYU Ballroom Dance Company, which was founded by his uncle, Benjamin F. de Hoyos. Fuentes studied particularly under Dallas Anderson.
Fuentes had first trained in modeling in the taxidermy shop of his father, Arturo Fuentes.
For several years prior to 1984, Fuentes ran a wood pallet construction factory in Saltillo with his wife Cynthia. The factory went under in 1984 and Fuentes decided to become a full-time sculptor. He was commission by the government to make a sculpture for the 400th anniversary of Saltillo. This was commission by the governor of the state of Coahuila. This four-figure sculpture which is 18 feet (5.5 m) tall is the most famous sculpture in the state of Coahuila. Fuentes' sculpture "Rose" is part of the permanent collection of the Springville Art Museum.
Fuentes is also a guitar player. He has formed a duo with singer Rebecca Lopez and also was part of El Trio Illusion with Carlos Saine and Dante Moreno.
Fuentes and his wife are the parents of five children.
# WKBZ

WKBZ (1090 AM) is a news/talk radio station in Muskegon, Michigan owned by iHeartMedia, Inc.

## History

The current WKBZ is the former WMUS. WMUS began operations in 1947 and became the second radio station serving Muskegon, after the original WKBZ (today's WSMZ); it began as a general-interest independent variety station featuring Associated Press newscasts. WMUS also inaugurated the first FM broadcasts in Muskegon in the summer of 1947, just a few months after the AM signed on, with WMUS-FM at 100.5; the FM station was dark by the start of the 1950s but came back on at its current frequency in 1962.
WMUS moved into a MOR/beautiful music format in the early 1960s, promoting itself as "the AM station with the FM sound" (1). Then in 1965, WMUS changed format to country music using the moniker "Top Gun Radio." A few years later WMUS-FM 106.9 began to simulcast WMUS's country format, and eventually the roles were reversed, with WMUS-FM becoming the primary signal and WMUS becoming the simulcast. This continued until April 2001, when both stations were sold to Clear Channel Communications. The AM facility adopted a news/talk format, while the FM facility remained unchanged. In April 2005, the call sign of WMUS was changed to WKBZ, marking the return of the call letters to the radio market after 4 years of absence. (They had been on the 850 frequency, now WSMZ, from 1926 to 1999, and on 1520 kHz from 1999 to 2001.)
# Lancha Plana, California

Lancha Plana (Spanish for "Flat Boat") was a small settlement in Amador County, California, formed as a result of a flatboat ferry crossing across the Mokelumne River.

## History

It was founded by Mexican miners in 1848. The remnants of the town were submerged as a result of the damming of the river to form the Camanche Reservoir. Lancha Plana Bridge crosses the lake now about where the town once stood. It was briefly known as "Sonora Bar", as most miners were from Sonora.
Lancha Plana is registered as a California Historical Landmark.
A post office operated at Lancha Plana from 1859 to 1919, with a closure from 1912 to 1913.

## Geography

It lay on the north bank of the Mokelumne River, 9 miles (14 km) south-southeast of Ione, at an elevation of 220 feet (67 m).
# Will Shetterly

Will Shetterly (born 1955) is an American writer of fantasy and science fiction best known for his novel Dogland (1997). The novel is inspired by his childhood at the tourist attraction Dog Land owned by his parents. He won the Minnesota Book Award for Fantasy & Science Fiction for his novel Elsewhere (1991), and was a finalist with Nevernever (1993); both books are set in Terri Windling's The Borderland Series shared universe. He has also written short stories for various Borderland anthologies.

## Biography

Shetterly is married to the author Emma Bull. The couple lives in Minneapolis, Minnesota, and were both members of the writing group The Scribblies, which also included, Pamela Dean, Kara Dalkey, Nate Bucklin, Patricia Wrede, and Steven Brust. Shetterly and Bull created and edited the Liavek shared universe anthologies.
Shetterly created the comic book character Captain Confederacy, played a small role in the film Toxic Zombies, and ran for governor of Minnesota in 1994 on the Grassroots Party ticket.
In 2009, he donated his archive to the department of Rare Books and Special Collections at Northern Illinois University.
# Cercopithecine gammaherpesvirus 14

Cercopithecine gammaherpesvirus 14 (CeHV-14) is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.
# Zippel Township, Lake of the Woods County, Minnesota

Zippel Township is a township in Lake of the Woods County, Minnesota, United States. The population was 140 at the 2000 United States census.

## Geography

According to the United States Census Bureau, the township has a total area of 33.3 square miles (86.2 km$^2$), of which 32.6 square miles (84.5 km$^2$) is land and 0.7 square mile (1.7 km$^2$) (1.98%) is water.

## Demographics

As of the census of 2000, there were 140 people, 61 households, and 43 families residing in the township. The population density was 4.3 people per square mile (1.7/km$^2$). There were 142 housing units at an average density of 4.4/sq mi (1.7/km$^2$). The racial makeup of the township was 99.29% White, and 0.71% from two or more races.
There were 61 households, out of which 21.3% had children under the age of 18 living with them, 65.6% were married couples living together, and 27.9% were non-families. 24.6% of all households were made up of individuals, and 8.2% had someone living alone who was 65 years of age or older. The average household size was 2.30 and the average family size was 2.75.
In the township the population was spread out, with 18.6% under the age of 18, 5.0% from 18 to 24, 26.4% from 25 to 44, 33.6% from 45 to 64, and 16.4% who were 65 years of age or older. The median age was 45 years. For every 100 females, there were 141.4 males. For every 100 females age 18 and over, there were 128.0 males.
The median income for a household in the township was $20,750, and the median income for a family was $32,500. Males had a median income of $33,750 versus $26,250 for females. The per capita income for the township was $22,272. There were none of the families and 24.3% of the population living below the poverty line, including no under eighteens and 33.3% of those over 64.
# WICE-LP

WICE-LP is a low-power F.M. radio station licensed to operate on 97.1 MHz at Hendersonville, North Carolina by the Federal Communications Commission. It was assigned the WICE-LP callsign on July 15, 2009.