OpenLLM-France/wikimedia huggingface dataset:
# Bright Meadows

The John Paul II Bright Meadows Square, commonly known as the Bright Meadows, and until 1945 known as Quistorp Meadow, is a garden square in the city of Szczecin, Poland. It is located in the neighbourhood of Śródmieście-Północ, within the district of Śródmieście. The park borders Szczecin City Hall to the south, and Jan Kasprowicz Park to the north. The square was opened in the 1927.

## Characteristics

The park consists of a long rectangle-shaped lawn surrounded by alleys on its sides, with rows of flowers and London plane trees.
It is located in the district of Śródmieście, in the Śródmieście-Północ municipal neighbourhood. The park borders Szczecin City Hall to the south, and Jan Kasprowicz Park to the north, with the Monument to Polish Endeavor at its entrance. The Monument of John Paul II, located within the park, was designed by Czesław Dźwigaj and Stanisław Latour and constructed in 1987.

## History

The park was built between 1925 and 1927, on the land donated in 1925 to the city by Martin Quistorp. Square was named after him, the Quistorp Meadow (German: Quistorp-Aue). Following World War II, when the city of Szczecin, Poland was transferred from the occupied Germany to Poland, the park was renamed to the Bright Meadows (Polish: Jasne Błonia).
Throughout its history, various events and festivals were hosted in the park, including the Trzymamy Straż Nad Odrą in 1946, and the meeting with Nikita Khrushchev, leader of the Soviet Union, in 1959.
In 1979, at the entrance to the Jan Kasprowicz Park from the Bright Meadows, was built the Monument to the Polish Endeavor, designed by artist Gustaw Zemła.
On 11 June 1987, Pope John Paul II had performed a mass at the Bright Meadows, during his visit to Poland. The altar had been placed in front of the Monument to the Polish Endeavor. In 1987, in the park was placed the Monument of John Paul II, to commemorate this event. It was designed by Czesław Dźwigaj and Stanisław Latour. In 1995, the square had been given full official name, that is the John Paul II Bright Meadows Square. It continues to be commonly referred to simply as the Bright Meadows.
In 2004, the square was included on the voivodeship heriatage register.
# JWH-138

JWH-138 (THC-Octyl, Δ$^8$-THC-C8) is a synthetic cannabinoid first synthesized by Roger Adams and studied heavily by John W. Huffman, with a K$_i$ of 8.5nM at the CB$_1$ cannabinoid receptor. THC-Octyl and its hydrogenated analog HHC-Octyl was synthesized and studied by Roger Adams as early as 1942.

## Isomers

The Δ$^3$/Δ$^{6a(10a)}$ isomer was synthesised in 1941, but was found to be slightly less active than Δ$^3$-THC itself. The alternate isomer Δ$^9$-THC-C8 has also been synthesised, and both the Δ$^8$ and Δ$^9$ isomers are included within the definition of an "intoxicating cannabinoid" in Colorado under the name tetrahydrocannabioctyl, but it is unclear if it has been identified as a natural product. Tetrahydrocannabioctyl is sometimes referred to as THC-Octyl or THC-O, which may cause confusion with THC-O-acetate which is commonly known as THC-O on packaging for grey market vaping liquids sold for use in humans.
# Anga Express

The 12253 / 12254 Anga Express is a train connecting Bhagalpur, the second largest city of Bihar, to Sir M. Visvesvaraya Terminal, Bengaluru (SMVB) in Bangalore, via Munger's Jamalpur Junction, Kolkata's Dankuni Junction, Bhubaneswar, Visakhapatnam and Vijayawada. In February 2017, the train was provided with the new LHB coach.

## History

The Anga Express was introduced because of the growing demand for the train service from the Anga region to Bangalore. Many of the software professionals working in Bangalore were from the districts of Munger and Bhagalpur. Prior to the Anga Express, they used to travel to Bangalore on the Sanghamithra Superfast Express or the Howrah–SMVT Bengaluru Humsafar Express.

## Timing

* 12253 – Starts from Sir M. Visvesvaraya Terminal, Bengaluru every Saturday at 13:30 HRS IST and reaches Bhagalpur Junction Monday at 8:45 AM IST
* 12254 – Starts from Bhagalpur Junction every Wednesday and reaches Sir M. Visvesvaraya Terminal, Bengaluru on Friday at 9:05 AM IST.

## Direction reversals

The train reverses its direction twice at:
* Visakhapatnam,
* Kiul Junction.

## Route & halts

* Bhagalpur Junction
* Kiul Junction
* Jasidih Junction
* Asansol Junction
* Barddhaman Junction
* Dankuni Junction
* Kharagpur Junction
* Balasore
* Cuttack Junction
* Bhubaneswar
* Khurda Road Junction
* Brahmapur
* Vizianagaram Junction
* Visakhapatnam
* Rajahmundry
* Vijayawada Junction
* Nellore
* Gudur Junction
* Renigunta Junction
* Katpadi Junction
* Jolarpettai Junction
* Krishnarajapuram
* SMVT Bengaluru

## Traction

It is hauled by a Tatanagar Loco Shed or Santragachi Loco Shed-based WAP-7 electric locomotive from BGP to VSKP. From VSKP to SMVB it is hauled by a Lallaguda Loco Shed or Royapuram Loco Shed-based WAP-7 electric locomotive and vice versa.
# Tipiracil

Tipiracil is a drug used in the treatment of cancer. It is approved for use in form of the combination drug trifluridine/tipiracil for the treatment of unresectable advanced or recurrent colorectal cancer.
Tipiracil helps maintain the blood concentration of trifluridine by inhibiting the enzyme thymidine phosphorylase which metabolizes trifluridine.

## Adverse effects

Adverse effects were not assessed independently of trifluridine, but only in the combination drug.

## Interactions

Only in vitro interaction studies are available. In these, tipiracil was transported by the solute carrier proteins SLC22A2 and SLC47A1. Drugs that interact with these transporters could influence blood plasma concentrations of tipiracil.

## Pharmacology
### Mechanism of action

Tipiracil is a thymidine phosphorylase (TPase) inhibitor and inhibits degradation of trifluridine by inhibiting TPase, thus increasing systemic exposure to trifluridine when tipiracil is given together with trifluridine.

### Pharmacokinetics

At least 27% of tipiracil is absorbed from the gut. In cancer patients, highest blood plasma concentrations are reached after three hours. The substance has no tendency to accumulate in the body. The in vitro protein binding in human plasma is below 8%. Tipiracil is not metabolized by cytochrome P450 (CYP) enzymes. To a small extent, it is hydrolyzed to 6-hydroxymethyluracil, but the main fraction is excreted in unchanged form in the faeces (50%) and urine (27%). Elimination half-life is 2.1 hours on the first day and then slightly increases to 2.4 hours on the twelfth day.
Tipiracil causes C$_{max}$ (highest blood plasma concentrations) of trifluridine to increase 22-fold, and its area under the curve 37-fold.

## Chemistry

Tipiracil is used in form of the hydrochloride, which is a white crystalline powder. Solubility in water is 5 mg/mL; it is also soluble in 0.01 M hydrochloric acid and 0.01 M sodium hydroxide; slightly soluble in methanol; very slightly soluble in ethanol; and practically insoluble in acetonitrile, isopropyl alcohol, acetone, diisopropyl ether, and diethyl ether.

## COVID-19

Tipiracil has been shown to inhibit SARS-CoV-2 Nsp15 and interacts with the uridine binding pocket of the enzyme's active site using a combination of crystallography, biochemical and whole cell assays. It had previously been suggested in a computational drug repurposing study as the most promising hit targeting the main SARS-CoV-2 protease.
# Tropoxane

Tropoxane (O-1072) is an aryloxytropane derivative drug developed by Organix Inc., which acts as a stimulant and potent dopamine and serotonin reuptake inhibitor. It is an analogue of dichloropane where the amine nitrogen has been replaced by an oxygen ether link (at the bridgehead position), demonstrating that the amine nitrogen is not required for DAT binding and reuptake inhibition.

## Thia analog

The 8-thiabicyclo(3.2.1)octanes analogs such as O-4210 have been prepared. A representative set of analogs is listed below.
MAT IC50 (nM) 8-thiabicyclo[3.2.1]octanes :
| X | Com | DAT | SERT | Com | DAT | SERT | Com | DAT | SERT |
| H | 1a | 910 | >10uM | 2a | 140 | >8uM | 3a | 117 | >3uM |
| F | 1b | 220 | >30uM | 2b | 59 | >11uM | 3b | 38 | 494 |
| Cl | 1c | 13 | >10uM | 2c | 11 | 1uM | 3c | 9.6 | 33 |
| Br | 1d | 9.1 | >25uM | 2d | 6.0 | 342 | 3d | 6.0 | 14 |
| I | 1e | 6.7 | >8uM | 2e | 9.0 | 70 | 3e | 14 | 10 |
| Cl$_2$ | 1f | 4.5 | >3uM | 2f | 6.9 | 99 | 3f | 5.7 | 8.0 |
| BN | 1g | 8.0 | >1uM | 2g | 8.0 | 36 | 3g | 16 | 13 |
It had been hypothesized that transporter binding of the tropanes might include ionic bonding of the central tropane nitrogen. But it turned out that at this site neither ionic nor hydrogen bonding is a prerequisite for potent monoamine reuptake inhibition. Oxa- and thia-analogs of RTI-111 are potent inhibitors, and even an N-replacement by methylene holds the potency within the same magnitude. However, N-quaternisation (N-dimethyl) considerably reduces DAT affinity.
In this SAR, the focus is on seeing the effect of changing 8-NMe to S, O, or CH2. Both enantiomers, as well as the racemates are presented in several cases for comparison.
MAT IC50 (nM) Cl2 bicyclo[3.2.1]octanes :
| Enant. | X | Com | DAT | SERT | Com | DAT | SERT | Com | DAT | SERT |
| Rac | S | 1a | 4.5 | 3,600 | 2a | 6.9 | 99 | 3a | 5.7 | 8.0 |
| Rac | O | 1a | 10 | 6,000 | 2a | 3.1 | 64.5 | 3a | 3.3 | 6.5 |
| 1R | NMe | 1a | 1.2 | 867 | 2a | 0.4 | 27 | 3a | 1.1 | 2.5 |
| Rac | CH$_2$ | 1a | 7.1 | 5,160 | 2a | 13 | 166 | 3a | 9.6 | 33 |
# Hydroxyacid oxidase (glycolate oxidase) 1

Hydroxyacid oxidase (glycolate oxidase) 1 is a protein that in humans is encoded by the HAO1 gene.

## Function

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. Glycolate oxidase oxidizes glycolic acid to glyoxylate, and can also oxidize glyoxylate into oxalate. These reactions are central to the toxicity of ethylene glycol poisoning.
The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.
# Leung Sui Wing

Leung Sui Wing (Chinese: 梁帥榮; born 22 May 1958) is a former Hong Kong professional football player who played as a sweeper.

## Club career

He spent his entire career with Happy Valley. He was the Hong Kong Footballer of the Year in 1983 and 1986.

## International career

Leung was the captain of Hong Kong when Hong Kong beat China on 19 May 1985 in a FIFA World Cup qualifying match that eliminated China.
# Coin (department store)

Coin (Italian:, Venetian:) is an Italian upmarket department store chain dedicated to the worlds of apparel, home decorations, accessories and beauty. Its headquarters are located in Mestre.

## History

Coin was founded in 1916 in Pianiga, province of Venice, Veneto, Italy, by Vittorio Coìn, who obtained a street vendor license to sell fabrics and haberdashery items. In 1927 he opened a shop selling fabrics, yarns and linen in Mirano (Venice). Two years later a wholesale warehouse was opened in Dolo. After having strengthened the Mirano store (1931), a shop was opened (1933) and a warehouse (1937) in Mestre, followed by the store in Padua (1947).
In 1957 the Coin family opened a real multi-storey department store, the first in the chain, in Trieste, in the premises once occupied by Austrian department stores Öhler; in 1958 Coin still exceeded the regional boundaries by opening a large store in the centre of Bologna.
In 1962 it opened its flagship store in Milan at Piazza 5 Giornate.
The expansion continues touching Parma and Bergamo, up to the new large complex in Mestre in the city centre, developed on six floors with an area of nearly 20,000 m$^2$, plus a PAM supermarket in the basement. Between 1966 and 1974 warehouses were opened in Verona, Brescia, Vicenza, Varese, Pordenone, Vigevano, Mantua, Genoa, Livorno, Udine, Piacenza, Naples, Taranto and Ferrara.
Coin was the first retailer to develop a fidelity card program in Italy in 1986.

## Coin Group

The Coin Group owns OVS (Oviesse) (midmarket apparel department stores) and, since January 2010, UPIM, a midmarket apparel, home and beauty department stores chain previously part of La Rinascente Group.
# Sudhakar Tukaram Shrangare

Sudhakar Tukaram Shrangare is an Indian politician and a member of parliament to the 17th Lok Sabha from Latur constituency, Maharashtra. He won the 2019 Indian general election being a Bharatiya Janata Party candidate. Shrangare is a Buddhist. He is an official candidate of BJP in 2024 Lok Sabha elections from Latur Lok Sabha constituency. Further He Joined Indian National Congress on 29th October 2024.

## Positions held
### Within BJP

* Member of Zilla Parishad, Wadwal, Maharashtra (2017–2019)
* District planning board member in Zilla Parishad.
* Member of Parliament 17th Loksabha, Latur Constituency
# François al-Hajj

Major General François al-Hajj (Arabic: اللواء فرنسوا الحاج; Arabic pronunciation:, 28 July 1953 – 12 December 2007) was a Lebanese military officer. He was assassinated by a car bomb on 12 December 2007.

## Early life and education

Al Hajj was born in the southern Lebanese town of Rmaich on 28 July 1953. Hajj entered the military academy in 1972 and graduated in 1975.

## Military career

Al Hajj fought against the Israeli occupation in South Lebanon and was then transferred to head positions north of the Litani during the 1980s. From 1988 to 1989 he fought, under the leadership of Prime Minister General Aoun, against Syrian forces assaulting the "free zones" of West Beirut during the Lebanese Civil War, he also battled the Lebanese Forces militia. In addition, General Hajj, led the Lebanese Army operation in Dinnieh in 2000. He gained recognition as a brilliant commander during the 15-week operation against Fatah al-Islam in Nahr al-Bared camp northern Lebanon during Summer 2007. He was second in command in the Lebanese army and would have been a contender to replace General Sleiman in the event the latter was elected president. Hajj was promoted to the rank of major general after his killing.

## Assassination

On 12 December 2007, Hajj was assassinated through a car bomb blast in the suburb of Baabda. Four other people, including his bodyguard, also died in the attack. A BMW that contained 35 kilograms of TNT was exploded while Hajj's car drove by. The bomb was triggered by remote control.

## Honors and medals

General Francois Hajj received the following honors and medals:
* Medal of War
* Order of the Wounded
* National Cedar Medal of Honor
* Lebanese Order of Merit (3rd degree)
* Order of National Unity
* Order of the Dawn of the South
* Lebanese Order of Merit (1st class)
* National Cedar Medal
* Medal of Loyalty
* Cedar Medal of National Honor
* Commended by the Army Commander over 24 times.
# Worldmaking After Empire

Worldmaking After Empire: The Rise and Fall of Self-Determination is a 2019 non-fiction book about decolonization by Adom Getachew.

## Reception
### Reviews

Worldmaking After Empire has been reviewed in various academic journals, including Capital & Class, Constellations, Contemporary Political Theory, Ethics & International Affairs, History, The Journal of Development Studies, New West Indian Guide, Perspectives on Politics, and the Singapore Journal of Tropical Geography,

### Awards and honors

In 2020, Foreign Affairs named Worldmaking after Empire one of the best books of the year.
Awards for Worldmaking after Empire :
| Year | Organization | Award | Result |
| 2020 | African Studies Association | ASA Best Book Prize | Winner |
| 2020 | American Political Science Association, Foundations of Political Theory Section | First Book Award | Winner |
| 2020 | American Political Science Association, Politics & History Section | J. David Greenstone Book Prize | Winner (tie) |
| 2020 | International Studies Association, Theory Section | ISA Theory Best Book | Winner |
| 2020 | National Conference of Black Political Scientists | W.E.B. Du Bois Distinguished Book Award | Winner (tie) |
| 2021 | Caribbean Philosophical Association | Frantz Fanon Prize | Winner |
# Royal Communications

Royal Communications is a branch of the Private Secretary's Office of the Royal Household of the Sovereign of the United Kingdom responsible for media relations and communicating with various organisations and authorities on matters to do with The King and the Royal Family. Until early 2014, Royal Communications was known as the Royal Household Press Office.
The head of Royal Communications is the Communications Secretary to the King and Queen. The post is currently held by Tobyn Andreae.

## Communications Secretaries

In 2014, the press offices of members of the Royal Family merged for a time at Buckingham Palace, though individual Communications Secretaries for members of the Royal Family were retained. Those members of the Royal Family who do not have their own Communications Secretaries are represented by that of the King and Queen.
The current Communications Secretaries within the Royal Household are:
* Tobyn Andreae (Communications Secretary to the King and Queen)
* Lee Thompson (Communications Secretary to the Prince and Princess of Wales)
Former Communications Secretaries:
* Donal McCabe

## Former Press Office positions
### Director of Royal Communications (2014–2018)

* Sally Osman 2014–2018

### The Queen's Media Secretary (2016–2018)

* Steve Kingstone 2016–2018

### List of Communications & Press Secretary to The Queen

* James Roscoe 2013–2017
* Ailsa Anderson 2010–2013
* Samantha Cohen 2007–2010
* Miss Penelope Russell-Smith2002–07

### List of Deputy Press Secretary to The Queen

* Steve Kingstone 2013–2016
* James Roscoe 2012–2013
* Ed Perkins 2010–2012
* Ailsa Anderson 2007–2010
* Samantha Cohen2003–2007
* Penelope Russell-Smith 1998–2002
* Geoffrey Crawford 1993–1997
* John Haslam 1988–1993

### List of Communications Secretaries (1998–2002)

* Simon Walker 2000–2002
* Simon Lewis 1998–2000

### List of Press Secretaries to the Sovereign (1918–2002)

* Penelope Russell-Smith 2000–2002
* Geoffrey Crawford 1997–2000
* Charles Anson 1990–1997
* Robin Janvrin1987–1990
* Michael Shea1978–1987
* Ronald Allison 1973–1978
* Robin Ludlow, 1972–1973
* William Heseltine1968–1972
* Richard Colville 1947–1968
* Lewis Ritchie 1944–1947
vacant 1931–1944
* Sir Frank Mitchell 1920–1931
* Samuel Pryor 1918–1920

### List of Assistant Press Secretaries to the Sovereign

* 1947–1957: Alexander Hood
* 1958–1981: Anne Hawkins (Wall from 1975)
* 1959–1960: Joseph Bennet Odunton
* 1965–1967: William Heseltine
* 1970–1974: Lawrence Bryant
* 1982–1987: Vic Chapman
# Chrissie Mayr

Christine Mayr is an American conservative oriented stand-up comedian, internet entertainer and YouTuber.

## Biography

Mayr is a native of Rockville Centre, New York. While in college she had an internship with the television show Late Night with Conan O’Brien. She was associated with Upright Citizens Brigade and Magnet Theater, and by 2016, was producing shows at comedy clubs including Comedy at Stonewall. She was on Amazon Prime's show Comics Watching Comics and won in the fifth season. She has hosted a podcast called The Wet Spot on Compound Media, and another podcast called Chrissie Mayr Podcast.
In 2021, an article in The New Republic examining Compound Media, birthplace of the Proud Boys, said Mayr had "delved deep into QAnon conspiracy theories—believing and spreading them, that is—and attended the protests at Capitol Hill on January 6". Interviewed on a podcast by Megyn Kelly, Mayr said of the January 6 events, "I was there and anybody who was there on the 6th is, like, blown away by how, like, inaccurate the media coverage is." She told a newspaper that she planned to release a comedy album on the January 6 anniversary.

## Appearances

* Fox network's shows Laughs and Punchline
* The Wendy Williams Show
* Reelz
* The Chris Gethard Show
* The Travel Channel
* What Not To Wear
* The News and Why it Matters w/ Sara Gonzales
* Prime Time with Alex Stein
* Gutfeld!
* Compound Media
* TimCast IRL
* America's Got Talent
* The Megyn Kelly Show
* Holly Randall Unfiltered
# Heiko von der Leyen

Heiko Echter von der Leyen (born 2 June 1955) is a German physician. He was born into the von der Leyen family in Hanover, which belonged to the German nobility. Von der Leyen is married to Ursula von der Leyen, the President of the European Commission since 2019.

## Early life

Born in 1955, he is the son of physician Ulrich von der Leyen (1917–1992) and his wife Cornelia Maria née Groth (1922–2014). Von der Leyen's family are Lutheran members of the Evangelical Church of Germany.

## Career

Von der Leyen studied Medicine at the University of Hamburg before pursuing further studies at Hanover Medical School. From 1992 to 1996, he was a faculty member of Stanford University. He received his Habilitation doctorate at Hanover Medical School in 1998, and was appointed Adjunct Professor of Internal Medicine and Experimental Cardiology at Hanover Medical School in 2002.
Von der Leyen became the Director of Hanover Clinical Trial Center GmbH in 2005; Hanover Clinical Trial Center (HCTC) is an academic clinical research organization on the campus of Hanover Medical School. Since December 2020, he is Medical Director of the company Orgenesis, which specialises in cell and gene therapies. Von der Leyen resigned from his position on the supervisory board of Orgenesis in October 2022, after journalists reported that the Italian branch of Orgenesis had received EU research funds in the past.

## Personal life

In 1986, Heiko married Ursula, by birth a member of the Albrecht family. They have seven children. The family lived for four years in Stanford, California during the 1990s.
# KFSL-LP

KFSL-LP is a Classic Country formatted broadcast radio station. The station is licensed to and serving Fossil in Oregon. KFSL-LP is owned and operated by Wheeler County Broadcasters Association.

## History

The Fossil School District 21J, which originally launched the station back in 2005, donated the station to the Wheeler County Broadcasters Association on June 4, 2021.
# WGMX

WGMX (94.3 FM) is a radio station licensed to Marathon, Florida, United States.

## History

The station originally went on the air in 1976 as WMUM, Stereo Island, and was owned by John and June Thacker. It was a Class A FM station on 94.3 MHz and took the market by storm with its Easy Listening music format and limited commercial breaks, along with a fulltime local news department. The Thackers later bought local AM station, WFFG, and moved the FM operation to Boot Key, sharing studio and transmitter facilities.
The Thackers sold WMUM to Joe Nascone, who was from Pennsylvania and the call letters were changed to WGMX.
On June 8, 2011, WGMX changed their format from adult contemporary "Mix 94.3" to oldies, branded as "True Oldies".
On April 1, 2017, WGMX changed their format from oldies to classic hits, branded as "Mix 94.3".
The station was most recently owned by Jonathan Smith's Choice Radio Keys Corporation. Due to an inability to pay outstanding debts, the company assigned the licenses of WGMX and sister stations WFFG, WKEY-FM, and WKEZ-FM to a trustee on June 4, 2018, to be sold for the benefit of creditors. A sale of WGMX and WFFG to Joseph Nascone's The Great Marathon Radio Company was consummated on September 14, 2020, at a price of $35,000.