# U.S. Route 42

U.S. Route 42 (US 42) is an east–west United States highway that runs southwest–northeast for 350 miles (560 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling northeast, the highway ends in downtown Cleveland and traveling southwest ends in Louisville.
Interstate 71 (I-71) fully supplanted US 42 as an interurban highway in the early 1960s, relegating US 42 to its current role as an ordinary town-to-town surface road. Additionally, I-71 passes through Columbus, whereas US 42 bypasses Columbus. It remains intact as a route; no part of it has ever been diverted to any Interstate highway. It is not the "parent" of any US route with a related number.
In spite of its even number, US 42 is posted north–south in Ohio.

## Route description
### Kentucky

U.S. Route 42 starts in Louisville, Kentucky, heading northeast through Prospect on the Oldham County and Jefferson County line. From here US 42 is a two lane road passing through the northern Kentucky hills paralleling between Interstate 71 and the Ohio River. Next, it passes through Goshen near North Oldham High School, situated on the north side. US 42 continues through Oldham County into Trimble County. In Bedford US 42 intersects with US 421 and is concurrent through downtown. The route still heading northeast crosses into Carroll County prior to crossing the Kentucky River and entering Carrollton. US 42 follows northeast along the south bank of the Ohio River passing Markland Lock and Dam and KY 1039 Markland Dam Bridge which connects between Kentucky Speedway and Indiana. Heading east US 42 parallels the Ohio River passing through Warsaw, Gallatin County about 5 miles (8.0 km) prior to intersecting with US 127 starting an extended concurrency. US 127 heads south toward Glencoe, Owenton, and eventually Frankfort.
From the intersection with US 127, US 42 turns away from the Ohio River bank. US 42 enters Boone County about 2.25 miles (3.62 km) prior to intersecting with the western terminus of Kentucky Route 14 (KY 14). Continuing north US 42-127 in about 6 miles (9.7 km) intersects Beaver Road KY 338 creating a wrong-way concurrency between US 127 and KY 338: when going north, drivers are traveling east on US 42, north on US 127, and south on Kentucky 338. This continues for less than a mile until it intersects with Richwood Pike where KY 338 splits off continuing south.
Continuing north for several miles the US 42-127 intersects with KY 536 (Mount Zion Road). Prior to KY 536 Ryle High School sits on the road's west side. Just south of Ryle, US 42 turns from a two-lane country road to a five-lane road. US 42 passes through Union prior to continuing to the northeast with US 127. After a couple of miles, it crosses Interstate 71/Interstate 75. Entering Florence US 42 intersects with KY 842 and KY 237. Within Florence US 25 Dixie Highway joins in a concurrency with US 42-127 which takes on the name Dixie Highway. After crossing briefly into Elsmere, the route enters Erlanger. US 42 becomes almost entirely a commercial road for the duration of its length in Erlanger. Prior to leaving Erlanger, US 42 becomes narrower and more congested after it crosses KY 236.
US 42 is primarily a commercial road prior to crossing under I-275 and proceeds to turn back into an almost purely residential road with a few exceptions while going north. The route intersects with KY 1303 (Turkeyfoot Road) northern terminus. The Crestview Hills town center lies just south of I-275 on the east side of the road, between Dixie Highway and Turkeyfoot Road. Dixie Heights High School is less than a mile down the road on the western side. Two intersections later US 42 is joined with KY 371 for about 500 feet (150 m). After crossing I-71/I-75 again the road heads in a northeast direction closely parallel to I-71/I-75. As it heads north US 42 starts off mostly as a residential road, turning more and more into a commercial road.
As it winds down from the suburbs into Covington the highway's name changes from Dixie Highway to Pike Street prior to crossing I-71/I-75 again. US 25-42-127 turns left on Main St heading north and crossing KY 8. US 42 crosses into Ohio from Covington on the Clay Wade Bailey Bridge, together with US 25 and US 127.

### Ohio

US 42 stretches 241.8 miles (389.1 km) across Ohio. It is classified as 59.3% rural and 40.7% urban, with only 1.1 miles (1.8 km) coded as freeway (while running concurrently with US 23 in Delaware). The route begins in Cincinnati, then passes through Hamilton, Butler, Warren, Greene, Clark, Madison, Union, Delaware, Morrow, Richland, Ashland, Wayne and Medina, Cuyahoga counties prior to reaching its terminus in Cleveland. The route barely enters Butler and Wayne counties with about 3 miles (4.8 km) in each.
US 42 crosses into Cincinnati from Covington, Kentucky, on the Clay Wade Bailey Bridge, concurrent with US 127. US 42 heads northeast out of Cincinnati on Reading Road, which runs between I-71 and I-75. In 2020, the Cincinnati City Council approved a project to rename Reading Road to President Barack Obama Avenue from Downtown Cincinnati to Reading, pending private donations; all 30,000 signs are expected to be installed by September 2021. Reading Road intersects with I-275, then briefly enters Butler County. The Ohio Department of Transportation has given this portion of US 42 the name Columbus–Cincinnati Road, but it is locally known as Cincinnati–Columbus Road, a name that also appears on West Chester Township signs along the road.
The portion of US 42 in Warren County between Lebanon and Waynesville is designated "Sergeant Brian Dulle Memorial Highway", in honor of a Warren County Sheriff's deputy who was struck and killed along US 42 on May 10, 2011, by a stolen car, while he was laying out stop sticks to catch the driver.
The intersection with Spring Valley–Paintersville Road in Spring Valley Township, Greene County near the village of Spring Valley has been the site of numerous fail-to-yield accidents, including a double fatality in 2017. In October 2018, the Ohio Department of Transportation announced that it would convert the intersection into a "basic RCUT", which would add a median and replace all left turns with right-in/right-out turns and median U-turns. The project is expected to cost around $1.2 million and begin in late 2020.
In Xenia, the designation "Brigadier General Charles Young Memorial Historical Corridor" leaves US 68 and joins US 42 at the routes' junction, in honor of Young, a pioneering figure in US history, and at his death, the highest-ranking Black officer in the Regular Army.
Still in Xenia, the intersection of US 42 (North Columbus Street) and East Church Street, where US 42 formerly continued at an awkward angle, was converted to a roundabout on June 12, 2020, at a cost of approximately $1.1 million.
After leaving Xenia, the route and the memorial historical corridor cross into Wilberforce. There they pass the Charles Young Buffalo Soldiers National Monument, located at Young's former house. The memorial historical corridor ends at Campus Drive, on the campus of Wilberforce University, where Young had been a professor.
After Wilberforce, major cities along the route are London, Delaware, Mansfield, Ashland and Medina prior to reaching the Cleveland metropolitan area. In London US 42 intersects with I-70. Other than a short concurrency at each end, in Delaware are the only other two concurrencies with US routes. Entering Delaware from the south US 42 runs concurrent with US 23 in Delaware until the junction with US 36 which it follows east for about .25 miles (0.40 km) before turning back to the north. The 1.1-mile (1.8 km) concurrence with US 23 is the only stretch of US 42 that is categorized as a freeway in Ohio.
Heading into Cuyahoga County at Strongsville, US 42 intersects I-80, the Ohio Turnpike, and continues through Middleburg Heights, Parma Heights, and Parma heading into Cleveland and is known locally as Pearl Road. US 42 continues north intersecting with I-71 and nearby exits to I-90. The route is part of the Ohio & Erie Canalway Scenic Byway while continuing north on West 25th. At this point on the route the road is a business district surrounded by varying business and residents of the Ohio City neighborhood. Along this stretch of the route, can be found many historic buildings, including the West Side Market. The last stretch of US 42 is a concurrency with US 6.
The eastern/northern end of US 42 finds its terminus at the intersection of Superior Avenue and Ontario Street in the middle of Public Square in downtown Cleveland. This intersection also serves as the western terminus of US 322 coming from the east on Superior as well as the western termini of US 422, Ohio State Route 14 (SR 14), and SR 87 and the northern terminus of SR 8 coming from the south on Ontario.

## Major intersections

| State | County | Location | mi | km | Destinations | Notes |
| Kentucky | Jefferson | Louisville | 0.000 | 0.000 | US 31E north / US 60 west (East Main Street) | Outbound access only; western terminus of westbound US 42; west end of US 60 overlap |
| Kentucky | Jefferson | Louisville | 0.000 | 0.000 | US 31E / US 60 (Baxter Street) | Inbound access only; western terminus of eastbound US 42; west end of US 60 overlap |
| Kentucky | Jefferson | Louisville | 0.656– 0.667 | 1.056– 1.073 | I-64 | I-64 exit 7; to I-64 east and from I-64 west in eastbound US 42 direction, to I-64 west and from I-64 east in westbound US 42 direction |
| Kentucky | Jefferson | Louisville | 0.805 | 1.296 | US 60 east (Frankfort Avenue) | East end of US 60 overlap |
| Kentucky | Jefferson | Brownsboro Village–Druid Hills line | 3.890 | 6.260 | KY 1932 south (Chenoweth Lane) – St. Matthews | Northern terminus of KY 1932 |
| Kentucky | Jefferson | Louisville–Northfield line | 5.730– 5.801 | 9.222– 9.336 | I-264 to I-71 – Louisville Zoo | I-264 exit 22; former US 460 Byp. |
| Kentucky | Jefferson | Northfield | 5.920 | 9.527 | KY 22 east (Brownsboro Road) / Northfield Drive | Western terminus of KY 22 |
| Kentucky | Jefferson | Louisville | 6.795 | 10.935 | KY 22C east (Seminary Drive) | Western terminus of KY 22C |
| Kentucky | Jefferson | Prospect | 8.960 | 14.420 | I-265 / KY 841 south (Gene Snyder Freeway) to I-71 | KY 841 exit 37; southbound I-265/KY 841 entrance / northbound I-265/KY 841 exit |
| Kentucky | Jefferson | Prospect–Louisville line | 11.222 | 18.060 | KY 329 east (Covered Bridge Road) | Western terminus of KY 329 |
| Kentucky | Jefferson | Prospect–Louisville line | 11.355 | 18.274 | KY 3222 east (Rose Island Road) | Western terminus of KY 3222 |
| Kentucky | Oldham | North Oldham | 14.213 | 22.874 | KY 1793 north – Creasey Mahan Nature Preserve | Southern terminus of KY 1793 |
| Kentucky | Oldham | ​ | 17.869 | 28.757 | KY 1694 south (Gum Street) / Shiloh Lane | Northern terminus of KY 1694 |
| Kentucky | Oldham | ​ | 21.035 | 33.853 | KY 393 south – Buckner | Northern terminus of KY 393 |
| Kentucky | Oldham | ​ | 23.906 | 38.473 | KY 524 east (Westport Road) – Westport | Western terminus of KY 524 |
| Kentucky | Oldham | Russell Corner | 24.859 | 40.007 | KY 53 south to I-71 – La Grange | Northern terminus of KY 53 |
| Kentucky | Oldham | ​ | 28.346 | 45.618 | KY 524 west (Covington Ridge Road) – Westport | Eastern terminus of KY 524 |
| Kentucky | Oldham | ​ | 30.135 | 48.498 | KY 3223 south (Old Sligo Road) | Northern terminus of KY 3223 |
| Kentucky | Oldham | ​ | 30.513 | 49.106 | KY 1488 south (Organ Creek Road) | Northern terminus of KY 1488 |
| Kentucky | Henry | Sligo | 31.613 | 50.876 | KY 153 south (Pendleton Road) to I-71 / South 42 Loop | Northern terminus of KY 153 |
| Kentucky | Henry–Trimble county line | ​ | 32.316 | 52.008 | KY 157 east – Sulphur | Western terminus of KY 157 |
| Kentucky | Trimble | Abbott | 35.643 | 57.362 | KY 2868 west (Morton Ridge Road) | Eastern terminus of KY 2868 |
| Kentucky | Trimble | ​ | 38.892 | 62.591 | KY 3175 south (Sulphur-Bedford Road) | Northern terminus of KY 3175 |
| Kentucky | Trimble | Bedford | 39.893 | 64.202 | KY 754 west (Barebone Road) | Eastern terminus of KY 754 |
| Kentucky | Trimble | Bedford | 40.394 | 65.008 | US 421 south to I-71 / Spring Street – Frankfort | West end of US 421 overlap |
| Kentucky | Trimble | Bedford | 40.565 | 65.283 | US 421 north | East end of US 421 overlap |
| Kentucky | Trimble | ​ | 43.929 | 70.697 | KY 2871 south (Connector Road) | Northern terminus of KY 2871 |
| Kentucky | Trimble | ​ | 44.736 | 71.996 | KY 3176 north (Bells Ridge Road) | Southern terminus of KY 3176 |
| Kentucky | Carroll | ​ | 50.695 | 81.586 | KY 1226 west | Eastern terminus of KY 1226 |
| Kentucky | Carroll | ​ | 51.355 | 82.648 | KY 36 west – Milton | West end of KY 36 overlap |
| Kentucky | Carroll | Prestonville | 52.401 | 84.331 | KY 55 south to I-71 | Northern terminus of KY 55 |
| Kentucky | Carroll | Kentucky River | 52.537– 52.779 | 84.550– 84.940 | Carrollton–Prestonville Bridge | Carrollton–Prestonville Bridge |
| Kentucky | Carroll | Carrollton | 53.655 | 86.349 | KY 320 south (11th Street) | Northern terminus of KY 320 |
| Kentucky | Carroll | Carrollton | 54.054 | 86.991 | KY 36 east / KY 227 south to I-71 – Worthville, General Butler State Park | East end of KY 36 overlap; northern terminus of KY 227 |
| Kentucky | Carroll | Carrollton | 54.261 | 87.325 | KY 2350 south (Martin Road) | Northern terminus of KY 2350 |
| Kentucky | Carroll | ​ | 59.025 | 94.992 | KY 2949 south (South Fork Road) | Northern terminus of KY 2949 |
| Kentucky | Carroll | Ghent | 60.800 | 97.848 | KY 47 south (Main Cross Street) | Northern terminus of KY 47 |
| Kentucky | Gallatin | ​ | 65.911 | 106.073 | KY 184 south | Northern terminus of KY 184 |
| Kentucky | Gallatin | ​ | 66.492– 66.499 | 107.009– 107.020 | KY 1039 to I-71 – Markland Dam, Indiana | Interchange |
| Kentucky | Gallatin | Warsaw | 70.168 | 112.924 | KY 35 south to I-71 | Northern terminus of KY 35 |
| Kentucky | Gallatin | ​ | 75.214 | 121.045 | US 127 south | West end of US 127 overlap |
| Kentucky | Gallatin | ​ | 76.386 | 122.931 | KY 1992 north (Steeles Bottom Road) | Southern terminus of KY 1992 |
| Kentucky | Gallatin | ​ | 78.509 | 126.348 | KY 562 west | Eastern terminus of KY 562 |
| Kentucky | Boone | ​ | 80.651 | 129.795 | KY 2850 south | Northern terminus of KY 2850 |
| Kentucky | Boone | Hume | 82.521 | 132.805 | KY 14 east to I-71 | Western terminus of KY 14 |
| Kentucky | Boone | Beaverlick | 85.431 | 137.488 | KY 338 north / KY 1292 east (Beaver Road) – Big Bone Lick State Park | West end of KY 338 overlap; western terminus of KY 1292 |
| Kentucky | Boone | ​ | 85.979 | 138.370 | KY 338 south – Richwood | East end of KY 338 overlap |
| Kentucky | Boone | Union | 89.682 | 144.329 | KY 3060 east (Frogtown Road) / Double Eagle Drive | Western terminus of KY 3060 |
| Kentucky | Boone | Union | 90.485 | 145.621 | KY 536 (Hathaway Road / Mount Zion Road) – Union Business District | |
| Kentucky | Boone | Florence | 92.814 | 149.370 | KY 237 (Pleasant Valley Road / Gunpowder Road) | |
| Kentucky | Boone | Florence | 93.270 | 150.104 | KY 842 (Weaver Road) | |
| Kentucky | Boone | Florence | 94.322 | 151.797 | I-71 / I-75 – Cincinnati, Lexington, Louisville | I-75 exit 180 |
| Kentucky | Boone | Florence | 94.690 | 152.389 | KY 1829 east (Industrial Road) | Western terminus of KY 1829 |
| Kentucky | Boone | Florence | 95.593 | 153.842 | US 25 south (Dixie Highway) | West end of US 25 overlap |
| Kentucky | Boone | Florence | 95.994 | 154.487 | KY 1017 north (Turfway Road) | Southern terminus of KY 1017 |
| Kentucky | Kenton | Erlanger | 97.495 | 156.903 | KY 236 (Commonwealth Avenue) to I-75 south | |
| Kentucky | Kenton | Erlanger | 98.194 | 158.028 | KY 2373 north (Kenton Lands Road) | Southern terminus of KY 2373 |
| Kentucky | Kenton | Crestview Hills | 99.047– 99.082 | 159.401– 159.457 | I-275 to I-71 / I-75 / KY 17 – Airport | I-275 exit 83 |
| Kentucky | Kenton | Lakeside Park | 99.625 | 160.331 | KY 1303 south (Turkeyfoot Road) / Hudson Avenue | Northern terminus of KY 1303 |
| Kentucky | Kenton | Lakeside Park | 100.002 | 160.938 | KY 371 north (Buttermilk Pike) / Huckleberry Hill Drive | West end of KY 371 overlap |
| Kentucky | Kenton | Fort Mitchell | 100.086 | 161.073 | KY 371 south (Orphanage Road) | East end of KY 371 overlap |
| Kentucky | Kenton | Fort Mitchell | 101.221– 101.350 | 162.899– 163.107 | I-71 / I-75 – Lexington, Louisville, Cincinnati | I-75 exit 188 |
| Kentucky | Kenton | Fort Wright | 102.259 | 164.570 | KY 1072 south (Kyles Lane) to I-71 / I-75 | West end of KY 1072 overlap |
| Kentucky | Kenton | Fort Wright | 102.414 | 164.819 | KY 1072 north (Sleepy Hollow Road) | East end of KY 1072 overlap |
| Kentucky | Kenton | Covington | 104.127– 104.175 | 167.576– 167.653 | I-71 / I-75 | I-75 exit 191 |
| Kentucky | Kenton | Covington | 104.787 | 168.638 | 5th Street (KY 8 east) | One-way street |
| Kentucky | Kenton | Covington | 104.869 | 168.770 | 4th Street (KY 8 west) | One-way street |
| Ohio River | Ohio River | Ohio River | 105.2870.00 | 169.4430.00 | Clay Wade Bailey Bridge; Kentucky–Ohio line US 25 end; east end of US 25 overlap | Clay Wade Bailey Bridge; Kentucky–Ohio line US 25 end; east end of US 25 overlap |
| Ohio | Hamilton | Cincinnati | 0.47 | 0.76 | US 27 south / US 52 east (I-71 Alt. north) | South end of US 27/US 52 overlap |
| Ohio | Hamilton | Cincinnati | 0.57 | 0.92 | I-75 north / 4th Street | I-75 northbound entrance only |
| Ohio | Hamilton | Cincinnati | 0.64– 0.73 | 1.03– 1.17 | US 22 / SR 3 begin / US 50 / SR 264 west (Sixth Street Expressway) / I-75 – Dayton | Western terminus of US 22/SR 3 NB; ramps to/from US 50 are eastern terminus of SR 264; south end of US 22/SR 3 overlap; no access to I-75 south; I-75 exit 1C |
| Ohio | Hamilton | Cincinnati | 0.81 | 1.30 | US 27 north / US 52 west / US 127 north (Central Avenue) to I-75 | North end of northbound US 27/US 52/US 127 overlap |
| Ohio | Hamilton | Cincinnati | 0.97 | 1.56 | Seventh Street east ( US 22 east / SR 3 north) | One-way street; north end of US 22/SR 3 overlap |
| Ohio | Hamilton | Cincinnati | 1.09 | 1.75 | Ninth Street west ( US 22 west / SR 3 south) | One-way street |
| Ohio | Hamilton | Cincinnati | 1.21 | 1.95 | US 27 north / US 52 west / US 127 north (Central Parkway) | North end of southbound US 27/US 52/US 127 overlap |
| Ohio | Hamilton | Cincinnati | 2.06 | 3.32 | I-471 south / East Liberty Street – Newport KY | I-471 exit 7; I-471 southbound entrance / northbound exit only |
| Ohio | Hamilton | Cincinnati | 2.29– 2.58 | 3.69– 4.15 | I-71 / Eden Park Drive / Florence Avenue – Columbus | I-71 exit 2; northbound US 42 / northbound I-71 entrance and exit and southbound US 42 / southbound I-71 entrance and exit only |
| Ohio | Hamilton | Cincinnati | 5.69 | 9.16 | SR 4 north (Paddock Road) to I-75 | Southern terminus of SR 4 |
| Ohio | Hamilton | Cincinnati | 6.86– 6.97 | 11.04– 11.22 | SR 562 to I-71 / I-75 | SR 562 exit 2 |
| Ohio | Hamilton | Cincinnati | 8.24 | 13.26 | SR 561 (East Seymour Avenue) to I-75 | |
| Ohio | Hamilton | Reading | 9.90– 10.00 | 15.93– 16.09 | Galbraith Road | To SR 126; direct exit from SR 126 eastbound to US 42 |
| Ohio | Hamilton | Sharonville | 16.05– 16.22 | 25.83– 26.10 | I-275 to I-71 / I-75 – Dayton, Columbus | I-275 exit 46 |
| Ohio | Butler | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions |
| Ohio | Warren | Mason | 24.47 | 39.38 | SR 741 to I-71 / I-75 | |
| Ohio | Warren | Lebanon | 30.71 | 49.42 | SR 48 south / SR 63 west / SR 123 south (Main Street) | South end of SR 48/SR 123 overlap |
| Ohio | Warren | Lebanon | 30.86 | 49.66 | SR 123 north (Silver Street) | North end of SR 123 overlap |
| Ohio | Warren | Lebanon | 30.93 | 49.78 | SR 48 north (Broadway) | North end of SR 48 overlap |
| Ohio | Warren | Lebanon | 33.01 | 53.12 | To SR 48 south / I-71 (via SR 48T) / Miller Road | Northern terminus of unsigned SR 48T |
| Ohio | Warren | Waynesville | 39.97 | 64.33 | SR 73 – Franklin, Wilmington, Caesar Creek | |
| Ohio | Greene | ​ | 47.31 | 76.14 | SR 725 west – Spring Valley, Bellbrook, Centerville | Eastern terminus of SR 725 |
| Ohio | Greene | ​ | 52.42– 53.14 | 84.36– 85.52 | US 35 – Dayton, Washington CH | Interchange |
| Ohio | Greene | Xenia | 54.49 | 87.69 | US 35 Bus. west (Main Street) | South end of US 35 Bus. overlap |
| Ohio | Greene | Xenia | 54.79 | 88.18 | US 68 / SR 380 south (Detroit Street) | Northern terminus of SR 380 |
| Ohio | Greene | Xenia | 55.12 | 88.71 | US 35 Bus. east (Main Street) | North end of US 35 Bus. overlap |
| Ohio | Greene | Cedarville | 62.74 | 100.97 | SR 72 south (Main Street) / Xenia Avenue | South end of SR 72 overlap |
| Ohio | Greene | Cedarville | 62.88 | 101.20 | SR 72 north (North Main Street) / Chillicothe Street | North end of SR 72 overlap |
| Ohio | Clark | South Charleston | 73.98 | 119.06 | SR 41 (Chillicothe Street) | |
| Ohio | Madison | London | 84.79 | 136.46 | SR 38 south / SR 56 / SR 665 east (Main Street) / SR 142 begins | South end of SR 38/SR 142 overlap; western termini of SR 142 and SR 665 |
| Ohio | Madison | London | 84.98 | 136.76 | SR 142 east (East High Street) | North end of SR 142 overlap |
| Ohio | Madison | London | 85.20 | 137.12 | SR 38 north (Elm Street) | North end of SR 38 overlap |
| Ohio | Madison | Lafayette | 89.25– 89.47 | 143.63– 143.99 | US 40 – Springfield, Columbus | Interchange |
| Ohio | Madison | ​ | 90.90– 91.22 | 146.29– 146.80 | I-70 – Dayton, Columbus | I-70 exit 79 |
| Ohio | Madison | ​ | 92.09 | 148.20 | SR 29 – Mechanicsburg, West Jefferson | |
| Ohio | Union | Plain City | 103.35 | 166.33 | SR 161 (West Main Street) | |
| Ohio | Union | ​ | 104.37 | 167.97 | SR 736 north / Lambka Road – Marysville | Southern terminus of SR 736 |
| Ohio | Union | New California | 107.76– 107.93 | 173.42– 173.70 | US 33 – Marysville, Columbus | Interchange |
| Ohio | Delaware | ​ | 114.69 | 184.58 | SR 257 north / SR 745 south – Shawnee Hills | South end of SR 257 overlap; northern terminus of SR 745 |
| Ohio | Delaware | ​ | 115.26 | 185.49 | SR 257 south / Klondike Road | North end of SR 257 overlap |
| Ohio | Delaware | Delaware | 120.34 | 193.67 | South Sandusky Street | Interchange |
| Ohio | Delaware | Delaware | 120.42 | 193.80 | US 23 south | South end of US 23 overlap |
| Ohio | Delaware | Delaware | 121.50– 121.71 | 195.54– 195.87 | US 23 north / US 36 west / SR 521 west (William Street) to SR 37 west – Toledo, Marion | Interchange; north end of US 23 overlap; south end of US 36/SR 521 overlap |
| Ohio | Delaware | Delaware | 121.91 | 196.20 | US 36 east / SR 521 east (East William Street) | North end of US 36/SR 521 overlap |
| Ohio | Delaware | Delaware | 122.09 | 196.48 | SR 37 (East Central Avenue) to US 23 north | |
| Ohio | Delaware | Ashley | 131.79 | 212.10 | SR 229 – Norton, Marengo | |
| Ohio | Morrow | ​ | 134.89 | 217.08 | SR 746 north / CR 155 east – Caledonia | Southern terminus of SR 746 |
| Ohio | Morrow | Cardington | 139.71 | 224.84 | SR 529 (Marion Street) | |
| Ohio | Morrow | Mount Gilead | 145.01 | 233.37 | SR 61 south to I-71 | South end of SR 61 overlap |
| Ohio | Morrow | Mount Gilead | 145.61 | 234.34 | SR 95 (Marion Street) to I-71 – Mt. Gilead State Park | Unsigned SR 95A |
| Ohio | Morrow | Mount Gilead | 145.73 | 234.53 | SR 95 (High Street) | |
| Ohio | Morrow | Mount Gilead | 145.96 | 234.90 | SR 61 north (North Main Street) / West Union Street | North end of SR 61 overlap |
| Ohio | Morrow | Williamsport | 151.75 | 244.22 | SR 19 north / CR 22 east – Galion | Southern terminus of SR 19 |
| Ohio | Morrow | Johnsville | 156.42 | 251.73 | SR 314 – Shelby, Chesterville | |
| Ohio | Richland | Lexington | 162.14 | 260.94 | SR 97 west (West Main Street) | South end of SR 97 overlap |
| Ohio | Richland | Lexington | 162.22 | 261.07 | SR 546 south (Frederick Street) / Plymouth Street | Northern terminus of SR 546 |
| Ohio | Richland | Lexington | 162.96 | 262.26 | SR 97 east to I-71 – Bellville | North end of SR 97 overlap |
| Ohio | Richland | Mansfield | 168.73 | 271.54 | SR 13 south (South Main Street) to I-71 | South end of SR 13 overlap |
| Ohio | Richland | Mansfield | 169.05 | 272.06 | SR 13 north (South Diamond Street) – Mansfield Lahm Airport | North end of SR 13 overlap; south end of SR 13 Truck overlap |
| Ohio | Richland | Mansfield | 169.18 | 272.27 | US 42 Truck north / SR 13 Truck north (South Adams Street) | North end of SR 13 Truck overlap |
| Ohio | Richland | Mansfield | 169.45 | 272.70 | SR 430 west / Lincoln Highway west (Park Avenue East) | South end of SR 430 overlap; no left turn northbound |
| Ohio | Richland | Mansfield | 169.73 | 273.15 | SR 430 east / Lincoln Highway east (Park Avenue East) | North end of SR 430 overlap |
| Ohio | Richland | Mansfield | 170.02 | 273.62 | SR 39 / US 42 Truck south / SR 430 Truck (East Fifth Street) | |
| Ohio | Richland | ​ | 171.90– 172.26 | 276.65– 277.23 | US 30 to I-71 / Beal Road – Bucyrus, Wooster, Kingwood Center | Interchange |
| Ohio | Ashland | ​ | 177.12 | 285.05 | SR 603 – Olivesburg, Mifflin | |
| Ohio | Ashland | ​ | 179.58 | 289.01 | Claremont Avenue - Ashland | Interchange; northbound exit and southbound entrance |
| Ohio | Ashland | Ashland | 182.56 | 293.80 | SR 511 to SR 60 – Ashland, Hayesville, Loudonville | Interchange |
| Ohio | Ashland | Ashland | 184.05 | 296.20 | US 250 east to I-71 / SR 96 (East Main Street) – Wooster, Ashland | South end of US 250 overlap; eastern terminus of SR 96 |
| Ohio | Ashland | Ashland | 185.04 | 297.79 | US 250 west – Norwalk | North end of US 250 overlap |
| Ohio | Ashland | ​ | 189.48 | 304.94 | SR 89 – Polk, Jeromesville | |
| Ohio | Ashland | ​ | 190.88 | 307.19 | SR 302 – Savannah, Wooster | |
| Ohio | Ashland | ​ | 190.98 | 307.35 | SR 604 east | Western terminus of SR 604 |
| Ohio | Wayne | West Salem | 196.85 | 316.80 | SR 301 (Main Street) to I-71 north – Homerville, Lattasburg | |
| Ohio | Medina | ​ | 201.75– 201.94 | 324.69– 324.99 | US 224 west / SR 421 east – Findlay, Lodi | Interchange; south end of US 224 overlap; eastern terminus of SR 421 |
| Ohio | Medina | ​ | 205.61– 206.05 | 330.90– 331.61 | US 224 east / SR 421 west to I-71 – Akron, Lodi | Interchange; north end of US 224 overlap; western terminus of SR 421 |
| Ohio | Medina | Lafayette | 210.83 | 339.30 | SR 162 east (Wedgewood Road) – Akron | South end of SR 162 overlap |
| Ohio | Medina | ​ | 211.30 | 340.05 | SR 162 west (Chatham Road) – Spencer | North end of SR 162 overlap |
| Ohio | Medina | Medina | 215.57 | 346.93 | SR 3 south (South Court Street) | South end of SR 3 overlap |
| Ohio | Medina | Medina | 215.83 | 347.34 | SR 3 north / SR 18 east / SR 57 south (East Washington Street) | North end of SR 3 overlap |
| Ohio | Medina | Medina | 215.91 | 347.47 | SR 18 west / SR 57 north (West Liberty Street) | |
| Ohio | Medina | Brunswick | 223.07 | 359.00 | SR 303 (Center Road) – LaGrange, Hinckley | |
| Ohio | Cuyahoga | Strongsville | 228.40 | 367.57 | SR 82 (Royalton Road) | |
| Ohio | Cuyahoga | Strongsville | 230.25 | 370.55 | I-80 / Ohio Turnpike | Ohio Turnpike exit 161 |
| Ohio | Cuyahoga | Middleburg Heights | 231.44– 231.65 | 372.47– 372.80 | I-71 to Ohio Turnpike – Cleveland, Columbus | I-71 exit 234 |
| Ohio | Cuyahoga | Parma | 237.56 | 382.32 | SR 3 south (Ridge Road) to I-480 | South terminus of SR 3 concurrency |
| Ohio | Cuyahoga | Parma–Cleveland line | 238.06 | 383.12 | SR 17 (Brookpark Road) | |
| Ohio | Cuyahoga | Cleveland | 239.85 | 386.00 | SR 94 south (State Road) to I-480 | Northern terminus of SR 94 |
| Ohio | Cuyahoga | Cleveland | 241.10– 241.24 | 388.01– 388.24 | I-71 to I-90 | I-71 exit 245 |
| Ohio | Cuyahoga | Cleveland | 241.14 | 388.08 | Scranton Road – Level I Trauma Center | Interchange; northbound exit only |
| Ohio | Cuyahoga | Cleveland | 242.33– 242.44 | 389.99– 390.17 | I-90 west – Toledo | I-90 exit 170A; eastbound I-90 exit / westbound I-90 entrance only |
| Ohio | Cuyahoga | Cleveland | 243.11 | 391.25 | SR 10 (Lorain Avenue) | |
| Ohio | Cuyahoga | Cleveland | 243.66 | 392.13 | US 6 west / US 20 west / US 6 Alt. west (Detroit Avenue) | Southern terminus of US 6 / US 20 concurrency; eastern terminus of US 6 Alt. |
| Ohio | Cuyahoga | Cleveland | 243.73– 244.26 | 392.25– 393.10 | Detroit–Superior Bridge over Cuyahoga River | Detroit–Superior Bridge over Cuyahoga River |
| Ohio | Cuyahoga | Cleveland | 244.53– 244.63 | 393.53– 393.69 | US 6 east / US 322 east (Superior Avenue) / US 422 east / SR 8 south / SR 14 east / SR 43 south / SR 87 east (Ontario Street) / US 20 east (Euclid Avenue) | Public Square; northern terminus of US 6 / US 20 / US 42 concurrency; termini of US 322, US 422, SR 3, SR 8, SR 14 SR 43, SR 87 |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus Incomplete access Tolled |||||||