# C11orf16

Gene C11orf16, chromosome 11 open reading frame 16, is a protein in humans that is encoded by the C11orf16 gene. It has 7 exons, and the size of 467 amino acids.

## Gene
### Location

The gene C11orf16 is located on chromosome 11(p15.4), starting at 8,920,076bp and ending at 8,933,006bp.

### Gene neighborhood

Gene ASCL3 and AKIP1 are the neighbor genes of C11orf16 on chromosome 11.

### Expression
#### Human

The gene does not have high expression throughout the body tissues. The percentile rank within the sample are higher in pancreas, ovary, and appendix.

#### Mouse brain

Even though the gene does not have a significant high expression in the mouse brain, it is most expressed in midbrain, isocortex, olfactory areas, and medulla.

### Transcription factors

Some transcription factors that have the higher matrix similarity are Kruppel-like zinc finger protein 219, zinc finger protein 263, ZKSCAN12 (zinc finger protein with KRAB and SCAN domains 12), chorion-specific transcription factor GCMa, and Ras-responsive element binding protein 1.

## mRNA
### Isoform

The predicted C11orf16 transcript variant X1 is 2386bp long and has NCBI accession number of XM_017018013.1.

## Homology
### Paralogs

No paralogs were found for the C11orf16 gene through NCBI BLAST.

### Orthologs

| Description | Common name | NCBI accession ID | Query cover | E value | Identity | Date of divergence (MYA) |
| Homo sapiens | Human | NP_065694.2 | 100 % | 0 | 100% | N/A |
| Pongo abelii | Sumatran orangutan | PNJ24628 | 84% | 0 | 95% | 15.2 |
| Aotus nancymaae | Nancy Ma's night monkey | XP_012312127.1 | 88% | 0 | 84% | 42.6 |
| Chinchilla lanigera | Long-tailed chinchilla | XP_013367496.1 | 97% | 0 | 68% | 88 |
| Equus przewalskii | Przewalski's horse | XP_008512245.1 | 98% | 0 | 73% | 94 |
| Cervus elaphus hippelaphus | Central European red deer | OWK17675.1 | 99% | 0 | 67% | 94 |
| Hipposideros armiger | Great roundleaf bat | XP_019511755.1 | 99% | 0 | 65% | 94 |
| Neomonachus schauinslandi | Hawaiian monk seal | XP_021541375.1 | 99% | 0 | 66% | 94 |
| Lipotes vexillifer | Baiji | XP_007459933.1 | 98% | 0 | 68% | 94 |
| Myotis brandtii | Brandt's bat | XP_005874017.1 | 98% | 1e-174 | 67% | 94 |
| Chelonia mydas | Green sea turtle | XP_007057171.1 | 83% | 1e-57 | 37% | 320 |
| Balearica regulorum gibbericeps | Grey crowned crane | XP_010311948.1 | 70% | 6e-5 | 40% | 320 |

### Conservation

The gene C11orf16 is conserved in many animal species including mammals, avians, and reptiles.

## Protein
### Molecular weight

The predicted molecular weight of the protein encoded by C11orf16 is 51 kilodaltons.

### Domains and motifs

Several protein domains and motifs were found including CHD5-like protein, tyrosine kinase phosphorylation site, protein kinase C phosphorylation site, N-myristoylation site, casein kinase II phosphorylation site, and cGMP-dependent protein kinase phosphorylation site. The picture indicates the location of the motifs.

### Secondary structure

The protein is predicted to be made up with 21.2% of alpha helix, 15.2% of extended strand, and 63% of random coil.

### Post-translational modifications

No transmembrane helices, potential GPI-modification sites, or TM-proteins were found. There were seven predicted sumoylation sites, multiple phosporylation sites with most of them being unspecified, and nine glycosylation sites.

### Subcellular localization predictor

The protein is predicted to be localized to the nucleus with the probability of 47.8%; mitochondria with the probability of 26.1%.

### Protein interaction

Proteins C1orf105 (Chromosome 1 open reading frame 105), PWWP2A, and SMYD1(SET and MYND domain containing 1) were found to be interacting with C11orf16.

## Clinical significance
### Disease association

Protein coded by C11orf16 gene is also predicted to have 19.61% sequence identity to tumor suppressor p53-binding protein suggesting that this gene might be involved with tumor suppressing process.