# 2021–22 Liga TDP season

The 2021–22 Liga TDP season is the fourth-tier football league of Mexico. The tournament began on 9 September 2021 and finished on 3 June 2022.

## Competition format

The Tercera División (Third Division) is divided into 17 groups. For the 2009–2010 season, the format of the tournament has been reorganized to a home and away format, which all teams will play in their respective group. The 17 groups consist of teams which are eligible to play in the liguilla de ascenso for three promotion spots, teams who are affiliated with teams in the Liga MX, Liga de Expansión MX and Liga Premier and development teams, which are not eligible for promotion but will play that who the better team in a sixteen team filial playoff tournament for the entire season.
The league format allows participating franchises to rent their place to another team, so some clubs compete with a different name than the one registered with the FMF.
For the 2021–22 season there will be three promotions to the Liga Premier. Two to Serie A and one to Serie B.

## Group 1

Group with 12 teams from Campeche, Quintana Roo, Tabasco and Yucatán. NOTE: Puerto Aventuras (registered as Tulum) participated in the first half of the season, but withdrew from the league in January 2022 due to financial problems.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Campeche | Campeche, Campeche | La Muralla de Kin-Ha | 500 | — | — |
| Cantera Venados | Mérida, Yucatán | Carlos Iturralde | 15,087 | Venados | — |
| Chetumal | Chetumal, Quintana Roo | José López Portillo | 6,600 | – | – |
| Corsarios de Campeche | Campeche, Campeche | Universitario de Campeche | 4,000 | — | — |
| Deportiva Venados | Tamanché, Yucatán | Alonso Diego Molina | 2,500 | — | — |
| Inter Playa del Carmen | Playa del Carmen, Quintana Roo | Unidad Deportiva Mario Villanueva Madrid | 7,500 | Inter Playa del Carmen | — |
| Mayas Hunucmá | Telchac Pueblo, Yucatán | Campo San Pedro Telchac | 300 | — | — |
| Pejelagartos de Tabasco | Villahermosa, Tabasco | Ciudad Deportiva de Villahermosa | 1,000 | — | — |
| Pioneros Junior | Cancún, Quintana Roo | Cancún 86 | 6,390 | Pioneros de Cancún | — |
| Progreso | Progreso, Yucatán | 20 de Noviembre | 3,000 | Venados | — |
| Puerto Aventuras | Puerto Aventuras, Quintana Roo | Unidad Deportiva Puerto Maya | 1,000 | — | Tulum |
| Yucatán | Valladolid, Yucatán | Coronel Claudio Alcocer | 2,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Deportiva Venados | 20 | 16 | 4 | 0 | 52 | 11 | +41 | 55 | Advance to Liguilla de Ascenso |
| 2 | Cantera Venados | 20 | 11 | 6 | 3 | 34 | 20 | +14 | 42 | Advance to Liguilla de No Ascenso |
| 3 | Inter Playa del Carmen | 20 | 10 | 6 | 4 | 35 | 20 | +15 | 39 | Advance to Liguilla de Ascenso |
| 4 | Corsarios de Campeche | 20 | 8 | 7 | 5 | 21 | 18 | +3 | 35 | Advance to Liguilla de Ascenso |
| 5 | Pioneros Junior | 20 | 9 | 4 | 7 | 38 | 27 | +11 | 32 | Advance to Liguilla de Ascenso |
| 6 | Progreso | 20 | 8 | 4 | 8 | 30 | 28 | +2 | 30 | |
| 7 | Campeche | 20 | 8 | 3 | 9 | 22 | 31 | −9 | 29 | |
| 8 | Chetumal | 20 | 6 | 4 | 10 | 27 | 36 | −9 | 23 | |
| 9 | Pejelagartos de Tabasco | 20 | 6 | 4 | 10 | 18 | 27 | −9 | 24 | |
| 10 | Mayas Hunucmá | 20 | 2 | 6 | 12 | 18 | 38 | −20 | 15 | |
| 11 | Yucatán | 20 | 1 | 2 | 17 | 10 | 49 | −39 | 6 | |

## Group 2

Group with 11 teams from Chiapas and Oaxaca.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Alebrijes de Oaxaca | Oaxaca City, Oaxaca | Tecnológico de Oaxaca | 14,598 | Alebrijes de Oaxaca | – |
| Antequera | Oaxaca City, Oaxaca | General Manuel Cabrera Carrasquedo | 3,000 | – | – |
| Atlético Ixtepec | Ixtepec, Oaxaca | Brena Torres | 1,000 | — | – |
| CEFOR Chiapas | Tuxtla Gutiérrez, Chiapas | Flor de Sospo | 3,000 | – | – |
| Cruz Azul Lagunas | Lagunas, Oaxaca | Cruz Azul | 2,000 | Cruz Azul | – |
| Dragones de Oaxaca | Zimatlán de Álvarez, Oaxaca | Unidad Deportiva Ignacio Mejía | 1,000 | – | – |
| Lechuzas UPGCH | Tuxtla Gutiérrez, Chiapas | Flor de Sospo | 3,000 | – | – |
| Milenarios de Oaxaca | Oaxaca City, Oaxaca | General Manuel Cabrera Carrasquedo | 3,000 | – | – |
| Saraguatos de Palenque | Palenque, Chiapas | Rey Pakal | 1,000 | – | Atlético Altamira |
| UNICACH | Acala, Chiapas | Prof. Romeo González Espinoza | 1,000 | – | – |
| Universidad del Sureste | Comitán de Domínguez, Chiapas | Centro de Formación UDS | 500 | — | — |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Lechuzas UPGCH | 20 | 12 | 6 | 2 | 32 | 13 | +19 | 44 | Advance to Liguilla de Ascenso |
| 2 | Alebrijes de Oaxaca | 20 | 12 | 5 | 3 | 39 | 17 | +22 | 43 | Advance to Liguilla de No Ascenso |
| 3 | Cruz Azul Lagunas | 20 | 12 | 3 | 5 | 44 | 17 | +27 | 41 | Advance to Liguilla de Ascenso |
| 4 | Universidad del Sureste | 20 | 8 | 8 | 4 | 23 | 15 | +8 | 38 | Advance to Liguilla de Ascenso |
| 5 | UNICACH | 20 | 9 | 5 | 6 | 26 | 16 | +10 | 35 | Advance to Liguilla de Ascenso |
| 6 | Dragones de Oaxaca | 20 | 8 | 7 | 5 | 32 | 25 | +7 | 32 | |
| 7 | Milenarios de Oaxaca | 20 | 6 | 4 | 10 | 19 | 31 | −12 | 26 | |
| 8 | CEFOR Chiapas | 20 | 7 | 2 | 11 | 20 | 29 | −9 | 24 | |
| 9 | Antequera | 20 | 5 | 4 | 11 | 18 | 36 | −18 | 20 | |
| 10 | Atlético Ixtepec | 20 | 2 | 5 | 13 | 21 | 38 | −17 | 14 | |
| 11 | Saraguatos de Palenque | 20 | 3 | 3 | 14 | 12 | 49 | −37 | 13 | |

## Group 3

Group with 15 teams from Puebla, San Luis Potosí, Tlaxcala and Veracruz.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Atlético Hilanderos | Xalapa Enríquez, Veracruz | USBI | 4,000 | — | Toros Huatusco |
| Caballeros de Córdoba | Córdoba, Veracruz | Rafael Murillo Vidal | 3,800 | — | — |
| Delfines UGM | Nogales, Veracruz | UGM Nogales | 1,500 | — | — |
| Guerreros de Puebla | Puebla City, Puebla | Centro Estatal del Deporte Mario Vázquez Raña | 800 | – | – |
| Guerreros de Tlaxcala | Chiautempan, Tlaxcala | Unidad Deportiva Próspero Cahuantzi | 2,500 | – | – |
| Licántropos | Puebla, Puebla | Campos El Cóndor | 500 | — | — |
| Lobos Puebla | Puebla, Puebla | Centro Estatal del Deporte Mario Vázquez Raña | 800 | — | — |
| Los Ángeles | Puebla, Puebla | Centro Estatal del Deporte Mario Vázquez Raña | 800 | — | — |
| Papanes de Papantla | Papantla, Veracruz | Fénix Solidaridad | 3,000 | — | — |
| Poza Rica | Poza Rica, Veracruz | Heriberto Jara Corona | 10,000 | — | — |
| Reales de Puebla | Chachapa, Puebla | Unidad Deportiva Chachapa | 1,000 | — | — |
| Sozca | Lerdo de Tejada, Veracruz | Miguel Seoane Lavín | 1,000 | — | — |
| Sultanes de Tamazunchale | Tamazunchale, San Luis Potosí | Deportivo Solidaridad | 1,650 | – | – |
| Tantoyuca | Tantoyuca, Veracruz | Campo ADA | 1,000 | – | – |
| Tehuacán | Tehuacán, Puebla | Polideportivo La Huizachera | 1,000 | — | — |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Poza Rica | 28 | 22 | 4 | 2 | 69 | 23 | +46 | 71 | Advance to Liguilla de Ascenso |
| 2 | Caballeros de Córdoba | 28 | 17 | 7 | 4 | 52 | 29 | +23 | 61 | Advance to Liguilla de Ascenso |
| 3 | Licántropos | 28 | 18 | 4 | 6 | 56 | 25 | +31 | 60 | Advance to Liguilla de Ascenso |
| 4 | Delfines UGM | 28 | 18 | 3 | 7 | 55 | 28 | +27 | 58 | Advance to Liguilla de Ascenso |
| 5 | Tantoyuca | 28 | 12 | 9 | 7 | 44 | 33 | +11 | 50 | Advance to Liguilla de Ascenso |
| 6 | Papanes de Papantla | 28 | 11 | 7 | 10 | 46 | 36 | +10 | 45 | |
| 7 | Tehuacán | 28 | 12 | 7 | 9 | 38 | 37 | +1 | 45 | |
| 8 | Sozca | 28 | 10 | 5 | 13 | 34 | 41 | −7 | 37 | |
| 9 | Lobos Puebla | 28 | 10 | 5 | 13 | 40 | 46 | −6 | 37 | |
| 10 | Guerreros de Tlaxcala | 28 | 8 | 6 | 14 | 29 | 50 | −21 | 35 | |
| 11 | Sultanes de Tamazunchale | 28 | 8 | 5 | 15 | 38 | 54 | −16 | 31 | |
| 12 | Reales de Puebla | 28 | 7 | 5 | 16 | 22 | 50 | −28 | 28 | |
| 13 | Atlético Hilanderos | 28 | 7 | 4 | 17 | 28 | 51 | −23 | 28 | |
| 14 | Los Ángeles | 28 | 4 | 8 | 16 | 22 | 40 | −18 | 25 | |
| 15 | Guerreros de Puebla | 28 | 3 | 7 | 18 | 20 | 50 | −30 | 19 | |

## Group 4

Group with 16 teams from Greater Mexico City.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Álamos | Iztacalco, Mexico City | Deportivo Plutarco Elías Calles | 300 | – | – |
| Aragón | Venustiano Carranza, Mexico City | Deportivo Plutarco Elías Calles | 300 | Pachuca | Atlético San Juan de Aragón |
| Athletic Club Esmeralda | Tultitlán, State of Mexico | ESMAC | 1,000 | – | Valle de Xico F.C. |
| Aztecas AMF Soccer | Venustiano Carranza, Mexico City | Deportivo Plutarco Elías Calles | 300 | – | – |
| Club Carsaf | Venustiano Carranza, Mexico City | Deportivo Lázaro Cárdenas | 1,000 | – | – |
| Cefor Mario Gálvez | Venustiano Carranza, Mexico City | Deportivo Plutarco Elías Calles | 300 | – | Marina |
| Chilangos | Benito Juárez, Mexico City | Deportivo Benito Juárez | 1,000 | – | – |
| Cuervos Blancos | Cuautitlán, State of Mexico | Los Pinos | 5,000 | – | – |
| Cuervos de Silver Soccer | Xochimilco, Mexico City | San Isidro | 1,200 | – | – |
| Escorpiones | Ecatepec, State of Mexico | Canchas Titanium | 500 | Escorpiones | – |
| Halcones de Rayón | Iztacalco, Mexico City | Magdalena Mixhuca Sports City Ground 1 | 500 | – | – |
| Muxes | Texcoco, State of Mexico | Unidad Deportiva Silverio Pérez | 1,500 | – | – |
| Novillos Neza | Venustiano Carranza, Mexico City | Deportivo Eduardo Molina | 500 | – | – |
| Oceanía | Venustiano Carranza, Mexico City | Deportivo Oceanía | 1,000 | – | – |
| Politécnico | Venustiano Carranza, Mexico City | Deportivo Leandro Valle | 1,000 | – | – |
| R-Reyes | Venustiano Carranza, Mexico City | Deportivo Plutarco Elías Calles | 300 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Muxes | 30 | 27 | 3 | 0 | 114 | 4 | +110 | 86 | Advance to Liguilla de Ascenso |
| 2 | Cuervos Blancos | 30 | 20 | 5 | 5 | 62 | 31 | +31 | 69 | Advance to Liguilla de Ascenso |
| 3 | Cuervos de Silver Soccer | 30 | 18 | 6 | 6 | 64 | 30 | +34 | 64 | Advance to Liguilla de Ascenso |
| 4 | Chilangos | 30 | 17 | 6 | 7 | 59 | 31 | +28 | 60 | Advance to Liguilla de Ascenso |
| 5 | Aragón | 30 | 16 | 8 | 6 | 70 | 28 | +42 | 58 | Advance to Liguilla de Ascenso |
| 6 | Club Carsaf | 30 | 15 | 8 | 7 | 44 | 23 | +21 | 57 | Advance to Liguilla de Ascenso |
| 7 | Álamos | 30 | 13 | 6 | 11 | 44 | 33 | +11 | 50 | Advance to Liguilla de Ascenso |
| 8 | Politécnico | 30 | 12 | 7 | 11 | 32 | 41 | −9 | 47 | |
| 9 | Escorpiones | 30 | 13 | 3 | 14 | 43 | 45 | −2 | 42 | |
| 10 | Oceanía | 30 | 9 | 7 | 14 | 30 | 46 | −16 | 38 | |
| 11 | Athletic Club Esmeralda | 30 | 10 | 6 | 14 | 36 | 65 | −29 | 38 | |
| 12 | Halcones de Rayón | 30 | 8 | 8 | 14 | 43 | 70 | −27 | 35 | |
| 13 | R–Reyes | 30 | 3 | 9 | 18 | 26 | 63 | −37 | 24 | |
| 14 | Novillos Neza | 30 | 4 | 7 | 19 | 21 | 70 | −49 | 20 | |
| 15 | Aztecas AMF Soccer | 30 | 4 | 6 | 20 | 22 | 72 | −50 | 20 | |
| 16 | Cefor Mario Gálvez | 30 | 1 | 5 | 24 | 16 | 74 | −58 | 12 | |

## Group 5

Group with 15 teams from Greater Mexico City. NOTE: On October 28, 2021, Mayas Soccer F.C. was expelled from the League for not fulfilling its obligations as an affiliate.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Academia América Leyendas | Iztapalapa, Mexico City | Deportivo Leandro Valle | 1,000 | – | San José del Arenal |
| Ángeles de la Ciudad | Coyoacán, Mexico City | Deportivo Rosario Iglesias | 600 | – | – |
| Cañoneros | Venustiano Carranza, Mexico City | Deportivo Plutarco Elías Calles | 300 | Cañoneros | Promodep Central |
| CDM | Venustiano Carranza, Mexico City | Deportivo Plutarco Elías Calles | 300 | – | – |
| Dongu | Cuautitlán, State of Mexico | Los Pinos | 5,000 | Dongu | – |
| Ecatepec | Ecatepec de Morelos, State of Mexico | Adolfo López Mateos | 1,000 | – | – |
| Guerreros DDios | Xochimilco, Mexico City | San Isidro | 1,000 | – | – |
| Héroes de Zaci | Venustiano Carranza, Mexico City | Deportivo Lázaro Cárdenas | 1,000 | – | – |
| Independiente Mexiquense | Huehuetoca, State of Mexico | 12 de Mayo | 1,500 | – | – |
| León Izcalli | Cuautitlán Izcalli, State of Mexico | Hugo Sánchez Márquez | 3,500 | León | – |
| Loyalty | Huixquilucan de Degollado, State of Mexico | Alberto Pérez Navarro | 3,000 | – | – |
| Morelos | Ecatepec de Morelos, State of Mexico | Deportivo Siervo de la Nación | 1,000 | – | – |
| Olimpo | Venustiano Carranza, Mexico City | Momoxco | 3,500 | – | Colegio Once México |
| Sangre de Campeón | Tultitlán, State of Mexico | Cancha Nou Camp | 1,000 | – | – |
| Unión | Melchor Ocampo, State of Mexico | Deportivo Melchor Ocampo | 1,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | CDM | 28 | 20 | 7 | 1 | 75 | 22 | +53 | 71 | Advance to Liguilla de Ascenso |
| 2 | Guerreros DDios | 28 | 18 | 7 | 3 | 60 | 19 | +41 | 64 | Advance to Liguilla de Ascenso |
| 3 | Loyalty | 28 | 17 | 3 | 8 | 57 | 30 | +27 | 57 | Advance to Liguilla de Ascenso |
| 4 | Unión | 28 | 16 | 5 | 7 | 41 | 24 | +17 | 56 | Advance to Liguilla de Ascenso |
| 5 | Héroes de Zaci | 28 | 17 | 3 | 8 | 50 | 34 | +16 | 56 | Advance to Liguilla de Ascenso |
| 6 | Ángeles de la Ciudad | 28 | 14 | 7 | 7 | 48 | 24 | +24 | 53 | |
| 7 | Morelos | 28 | 14 | 5 | 9 | 46 | 36 | +10 | 50 | |
| 8 | Sangre de Campeón | 27 | 10 | 6 | 11 | 36 | 41 | −5 | 40 | |
| 9 | León Izcalli | 28 | 7 | 11 | 10 | 36 | 36 | 0 | 37 | |
| 10 | Academia América Leyendas | 28 | 9 | 6 | 13 | 33 | 48 | −15 | 36 | |
| 11 | Olimpo | 28 | 4 | 11 | 13 | 27 | 48 | −21 | 28 | |
| 12 | Dongu | 28 | 5 | 7 | 16 | 27 | 54 | −27 | 26 | |
| 13 | Independiente Mexiquense | 28 | 6 | 5 | 17 | 22 | 47 | −25 | 25 | |
| 14 | Ecatepec | 29 | 3 | 6 | 20 | 24 | 66 | −42 | 17 | |
| 15 | Cañoneros | 28 | 2 | 7 | 19 | 20 | 73 | −53 | 14 | |

## Group 6

Group with 12 teams from State of Mexico.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Águilas Talpa | Huehuetoca, State of Mexico | 12 de Mayo | 1,500 | – | Deportivo Talpa |
| Ciervos | Chalco, State of Mexico | Arreola | 3,217 | Chalco | Club de Ciervos F.C. |
| El Árbol Santa Fe | Metepec, State of Mexico | Jesús Lara | 500 | – | – |
| Estudiantes | Atlacomulco, State of Mexico | Municipal de Atlacomulco | 2,000 | – | – |
| Eurosoccer | San Mateo Atenco, State of Mexico | Municipal San Mateo Atenco | 2,500 | – | Deportivo Metepec |
| MACA | Metepec, State of Mexico | Jesús Lara | 500 | – | – |
| Proyecto México Soccer | Tenango del Valle, State of Mexico | Unidad Deportiva Alfredo del Mazo | 1,000 | – | Grupo Sherwood |
| Real San Luis | Metepec, State of Mexico | Colegio Miraflores Toluca | 500 | Aguacateros CDU | Originales Aguacateros |
| Sime Soccer | San Antonio la Isla, State of Mexico | Unidad Deportiva San Antonio la Isla | 1,000 | – | CH Fútbol Club |
| Tenancingo | Tenancingo, State of Mexico | JM "Grillo" Cruzalta | 3,000 | – | Fuerza Mazahua |
| Toluca | Metepec, State of Mexico | Instalaciones de Metepec | 1,000 | Toluca | – |
| Villa Flor | Villa Guerrero, State of Mexico | Municipal de Villa Guerrero | 1,500 | – | C.D. Apaseo El Alto |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Toluca | 22 | 15 | 5 | 2 | 47 | 18 | +29 | 54 | Advance to Liguilla de No Ascenso |
| 2 | Estudiantes | 22 | 15 | 5 | 2 | 67 | 20 | +47 | 53 | Advance to Liguilla de Ascenso |
| 3 | Sime Soccer | 22 | 15 | 4 | 3 | 38 | 14 | +24 | 51 | Advance to Liguilla de Ascenso |
| 4 | Proyecto México Soccer | 22 | 12 | 8 | 2 | 38 | 18 | +20 | 47 | Advance to Liguilla de Ascenso |
| 5 | El Árbol Santa Fe | 22 | 12 | 5 | 5 | 34 | 17 | +17 | 43 | Advance to Liguilla de No Ascenso |
| 6 | Tenancingo | 22 | 9 | 6 | 7 | 31 | 29 | +2 | 37 | |
| 7 | MACA | 22 | 8 | 3 | 11 | 28 | 30 | −2 | 29 | |
| 8 | Ciervos | 22 | 6 | 3 | 13 | 31 | 40 | −9 | 22 | |
| 9 | Villa Flor | 22 | 6 | 2 | 14 | 34 | 60 | −26 | 22 | |
| 10 | Real San Luis | 22 | 5 | 2 | 15 | 22 | 55 | −33 | 18 | |
| 11 | Águilas Talpa | 22 | 2 | 5 | 15 | 20 | 45 | −25 | 13 | |
| 12 | Eurosoccer | 22 | 1 | 4 | 17 | 11 | 55 | −44 | 7 | |

## Group 7

Group with 13 teams from Guerrero, Mexico City Morelos and State of Mexico.

### Teams

| Team | City | Home ground | Capacity | Official Name | Affiliate |
| Académicos Jojutla | Jojutla, Morelos | Unidad Deportiva La Perseverancia | 1,000 | – | – |
| Camaleones | Acapulco, Guerrero | Polideportivo CICI Renacimiento | 1,000 | – | – |
| Chilpancingo | Chilpancingo, Guerrero | Polideportivo Chilpancingo | 5,000 | – | – |
| FORMAFUTINTEGRAL | Ixtapaluca, State of Mexico | Campo La Era | 1,000 | – | – |
| Iguala | Iguala, Guerrero | Unidad Deportiva Iguala | 4,000 | – | – |
| Iguanas | Zihuatanejo, Guerrero | Unidad Deportiva Zihuatanejo | 1,000 | – | – |
| Juárez | Xochimilco, Mexico City | Deportivo Montesur | 1,000 | – | Juárez |
| Juniors Vidal Peralta | Tezoyuca, Morelos | Unidad Deportiva Vidal Peralta | 1,000 | Santiago Tulantepec | – |
| Leones | Chalco, State of Mexico | San Marcos | 1,000 | – | – |
| Selva Cañera | Jojutla, Morelos | Unidad Deportiva La Perseverancia | 1,000 | – | – |
| Tigres Yautepec | Yautepec, Morelos | Centro Deportivo Yautepec | 3,000 | Atlético Cuernavaca | – |
| Tlapa | Tlapa de Comonfort, Guerrero | Unidad Deportiva Tlapa | 1,000 | – | – |
| Yautepec | Yautepec, Morelos | Centro Deportivo Yautepec | 3,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Chilpancingo | 24 | 19 | 3 | 2 | 79 | 16 | +63 | 60 | Advance to Liguilla de Ascenso |
| 2 | Juárez | 24 | 16 | 6 | 2 | 58 | 15 | +43 | 57 | Advance to Liguilla de No Ascenso |
| 3 | Tigres Yautepec | 24 | 14 | 6 | 4 | 46 | 17 | +29 | 53 | Advance to Liguilla de Ascenso |
| 4 | Yautepec | 24 | 15 | 4 | 5 | 51 | 17 | +34 | 52 | Advance to Liguilla de Ascenso |
| 5 | Selva Cañera | 24 | 11 | 7 | 6 | 47 | 30 | +17 | 42 | Advance to Liguilla de Ascenso |
| 6 | Leones | 24 | 9 | 6 | 9 | 31 | 28 | +3 | 37 | Advance to Liguilla de No Ascenso |
| 7 | Juniors Vidal Peralta | 24 | 10 | 5 | 9 | 28 | 29 | −1 | 37 | |
| 8 | Iguala | 24 | 9 | 4 | 11 | 29 | 37 | −8 | 32 | |
| 9 | Académicos Jojutla | 24 | 6 | 6 | 12 | 34 | 51 | −17 | 27 | |
| 10 | FORMAFUTINTEGRAL | 24 | 7 | 4 | 13 | 27 | 45 | −18 | 27 | |
| 11 | Iguanas | 24 | 4 | 5 | 15 | 14 | 52 | −38 | 20 | |
| 12 | Tlapa | 24 | 4 | 3 | 17 | 11 | 71 | −60 | 15 | |
| 13 | Camaleones | 24 | 1 | 3 | 20 | 10 | 57 | −47 | 9 | |

## Group 8

Group with 16 teams from Hidalgo, Mexico City and State of Mexico.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Atlético Huejutla | Huejutla , Hidalgo | Capitán Antonio Reyes Cabrera "El Tordo" | 1,000 | – | – |
| Atlético Pachuca | Pachuca, Hidalgo | Revolución Mexicana | 3,500 | – | – |
| Atlético Toltecas | Tula, Hidalgo | Unidad Deportiva la Tortuga | 1,000 | – | – |
| Bombarderos de Tecámac | Tecámac, State of Mexico | Galaxias del Llano | 500 | – | – |
| CEFOR "Chaco" Giménez | Tulancingo, Hidalgo | Primero de Mayo | 2,500 | – | – |
| Ceforfema | Singuilucan, Hidalgo | Unidad Deportiva Singuilucan | 1,000 | – | Atlético Boca del Río |
| Faraones de Texcoco | Texcoco, State of Mexico | Claudio Suárez | 4,000 | – | – |
| Guerreros Aztecas IAFE | San Martín de las Pirámides, State of Mexico | Deportivo Braulio Romero | 1,000 | Alebrijes de Oaxaca | – |
| Guerreros de la Plata | Pachuca, Hidalgo | Horacio Baños | 1,000 | – | – |
| Halcones Negros | Chicoloapan de Juárez, State of Mexico | Unidad Deportiva San José | 1,000 | – | – |
| Halcones Zúñiga | Texcoco, State of Mexico | Unidad Deportiva Silverio Pérez | 1,000 | – | – |
| Hidalguense | Pachuca, Hidalgo | Club Hidalguense | 600 | – | – |
| MARNAP | Ixmiquilpan, Hidalgo | Deportivo Marnap | 1,000 | – | – |
| Matamoros | Papalotla, State of Mexico | IMCFD Papalotla | 1,000 | – | – |
| Sk Sport Street Soccer | Tulancingo, Hidalgo | Unidad Deportiva Javier Rojo Gómez | 2,000 | – | – |
| Tuzos Pachuca | San Agustín Tlaxiaca, Hidalgo | Universidad del Fútbol | 1,000 | Pachuca | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Faraones de Texcoco | 30 | 25 | 2 | 3 | 104 | 23 | +81 | 77 | Advance to Liguilla de Ascenso |
| 2 | Bombarderos de Tecámac | 30 | 21 | 6 | 3 | 72 | 27 | +45 | 71 | Advance to Liguilla de Ascenso |
| 3 | Tuzos Pachuca | 30 | 19 | 9 | 2 | 84 | 25 | +59 | 70 | Advance to Liguilla de Ascenso |
| 4 | Sk Sport Street Soccer | 30 | 20 | 2 | 8 | 71 | 30 | +41 | 63 | Advance to Liguilla de Ascenso |
| 5 | Atlético Pachuca | 30 | 16 | 7 | 7 | 62 | 28 | +34 | 59 | Advance to Liguilla de Ascenso |
| 6 | Hidalguense | 30 | 15 | 7 | 8 | 63 | 33 | +30 | 57 | |
| 7 | Matamoros | 30 | 15 | 4 | 11 | 64 | 41 | +23 | 50 | |
| 8 | Halcones Negros | 30 | 13 | 6 | 11 | 55 | 36 | +19 | 50 | |
| 9 | Atlético Toltecas | 30 | 9 | 7 | 14 | 43 | 54 | −11 | 38 | |
| 10 | Guerreros de La Plata | 30 | 10 | 5 | 15 | 41 | 59 | −18 | 36 | |
| 11 | CEFOR "Chaco" Giménez | 30 | 8 | 6 | 16 | 43 | 58 | −15 | 33 | |
| 12 | Atlético Huejutla | 30 | 9 | 3 | 18 | 35 | 77 | −42 | 32 | |
| 13 | MARNAP | 30 | 6 | 8 | 16 | 44 | 62 | −18 | 28 | |
| 14 | Ceforfema | 30 | 4 | 6 | 20 | 22 | 119 | −97 | 23 | |
| 15 | Halcones Zúñiga | 30 | 4 | 5 | 21 | 30 | 81 | −51 | 20 | |
| 16 | Guerreros Aztecas IAFE | 30 | 2 | 5 | 23 | 16 | 96 | −80 | 11 | |

## Group 9

Group with 15 teams from Guanajuato and Querétaro.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Atlético Cadereyta | Cadereyta de Montes, Querétaro | Unidad Deportiva Cadereyta | 1,100 | – | Atlético Queréndaro |
| Celaya | Celaya, Guanajuato | Miguel Alemán Valdés | 23,182 | Celaya | – |
| Celaya Linces | Celaya, Guanajuato | Unidad Deportiva Norte | 1,000 | – | – |
| Correcaminos Tequisquiapan | Tequisquiapan, Querétaro | Unidad Deportiva Emiliano Zapata | 1,000 | Correcaminos UAT | – |
| Estudiantes de Querétaro | Querétaro, Querétaro | Casa de la Juventud INDEREQ | 1,000 | – | – |
| Inter Aicesa SJR | Querétaro, Querétaro | Unidad Deportiva La Cañada | 2,000 | Inter de Querétaro | Querétaro 3D |
| Inter Fundadores | El Marqués, Querétaro | Parque Bicentenario | 1,000 | Inter de Querétaro | – |
| Inter de Querétaro | Querétaro, Querétaro | Unidad Deportiva La Cañada | 2,000 | Inter de Querétaro | – |
| Lobos ITECA | San Luis de la Paz, Guanajuato | El Internado | 1,500 | – | – |
| Mineros Querétaro | Colón, Querétaro | Universidad CEICKOR | 500 | Mineros de Zacatecas | – |
| Oro La Piedad Querétaro | Querétaro, Querétaro | El Infiernillo | 1,000 | – | – |
| Petroleros Querétaro | Querétaro, Querétaro | Casa de la Juventud INDEREQ | 1,000 | – | – |
| Real Marqués | El Marqués, Querétaro | Unidad Deportiva La Cañada | 2,000 | – | Cañada CTM |
| Strikers | San Miguel de Allende, Guanajuato | José María 'Capi' Correa | 4,000 | – | – |
| Titanes de Querétaro | Querétaro, Querétaro | IMSS Querétaro | 1,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Titanes de Querétaro | 28 | 23 | 5 | 0 | 93 | 17 | +76 | 76 | Advance to Liguilla de Ascenso |
| 2 | Petroleros Querétaro | 28 | 22 | 2 | 4 | 61 | 23 | +38 | 69 | Advance to Liguilla de Ascenso |
| 3 | Estudiantes de Querétaro | 28 | 21 | 1 | 6 | 69 | 23 | +46 | 64 | Advance to Liguilla de Ascenso |
| 4 | Inter Aicesa SJR | 28 | 18 | 2 | 8 | 63 | 30 | +33 | 57 | |
| 5 | Lobos ITECA | 28 | 16 | 6 | 6 | 62 | 50 | +12 | 56 | |
| 6 | Correcaminos Tequisquiapan | 28 | 14 | 4 | 10 | 58 | 35 | +23 | 47 | Advance to Liguilla de No Ascenso |
| 7 | Real Marqués | 28 | 10 | 9 | 9 | 44 | 41 | +3 | 45 | |
| 8 | Celaya Linces | 28 | 11 | 5 | 12 | 45 | 50 | −5 | 40 | |
| 9 | Celaya | 28 | 7 | 9 | 12 | 30 | 44 | −14 | 36 | |
| 10 | Mineros Querétaro | 28 | 9 | 4 | 15 | 43 | 70 | −27 | 34 | |
| 11 | Oro La Piedad Querétaro | 28 | 8 | 5 | 15 | 29 | 51 | −22 | 32 | |
| 12 | Strikers | 28 | 8 | 4 | 16 | 30 | 55 | −25 | 28 | |
| 13 | Inter de Querétaro | 28 | 2 | 8 | 18 | 21 | 54 | −33 | 17 | |
| 14 | Atlético Cadereyta | 28 | 3 | 5 | 20 | 19 | 63 | −44 | 17 | |
| 15 | Inter Fundadores | 28 | 2 | 3 | 23 | 16 | 77 | −61 | 11 | |

## Group 10

Group with 10 teams from Guanajuato and Michoacán. NOTE: Deportivo Yurécuaro was announced as a member of the group, however on September 29, 2021, the club withdrew from the league voluntarily.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Aguacateros de Peribán | Peribán, Michoacán | Paricutín | 2,000 | – | – |
| Atlético Chavinda | Chavinda, Michoacán | Club Campestre Chavinda | 500 | – | – |
| Cantereros Morelia | Morelia, Michoacán | Complejo Deportivo Bicentenario | 1,000 | – | Atlético Valladolid |
| Delfines de Abasolo | Abasolo, Guanajuato | Municipal de Abasolo | 2,500 | – | – |
| Furia Azul | Pátzcuaro, Michoacán | Furia Azul | 3,000 | – | – |
| H2O Purépechas | Morelia, Michoacán | Venustiano Carranza | 17,600 | Atlético Morelia | – |
| Huetamo | Huetamo, Michoacán | Unidad Deportiva Simón Bolívar | 1,000 | La Piedad | Degollado |
| Michoacán F.C. | Pátzcuaro, Michoacán | Furia Azul | 3,000 | – | – |
| Ocoteros de Cuerámaro | Cuerámaro, Guanajuato | Municipal Juan José Torres Landa | 1,000 | – | Jaral del Progreso |
| Soberano Zamora | Zamora, Michoacán | Unidad Deportiva El Chamizal | 5,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Aguacateros de Peribán | 18 | 14 | 3 | 1 | 56 | 13 | +43 | 48 | Advance to Liguilla de Ascenso |
| 2 | Michoacán F.C. | 18 | 11 | 4 | 3 | 38 | 16 | +22 | 39 | Advance to Liguilla de Ascenso |
| 3 | H2O Purépechas | 18 | 11 | 4 | 3 | 39 | 11 | +28 | 38 | Advance to Liguilla de Ascenso |
| 4 | Furia Azul | 18 | 9 | 6 | 3 | 34 | 22 | +12 | 37 | Advance to Liguilla de Ascenso |
| 5 | Soberano Zamora | 18 | 6 | 6 | 6 | 34 | 24 | +10 | 27 | |
| 6 | Delfines de Abasolo | 18 | 6 | 5 | 7 | 22 | 25 | −3 | 25 | |
| 7 | Huetamo | 18 | 5 | 4 | 9 | 25 | 34 | −9 | 21 | |
| 8 | Atlético Chavinda | 18 | 4 | 2 | 12 | 15 | 36 | −21 | 15 | |
| 9 | Ocoteros de Cuerámaro | 18 | 3 | 4 | 11 | 19 | 55 | −36 | 13 | |
| 10 | Cantereros Morelia | 18 | 1 | 2 | 15 | 12 | 58 | −46 | 7 | |

## Group 11

Group with 10 teams from Aguascalientes, Durango, Guanajuato, Jalisco and Zacatecas. NOTE: Atlético ECCA was announced as a team member of the group, however on September 29, 2021, it was expelled from the League for not fulfilling its obligations as an affiliate.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Alacranes de Durango | Durango, Durango | Cancha Anexa Francisco Zarco | 500 | Alacranes de Durango | – |
| Atlético Leonés | León, Guanajuato | Unidad Deportiva Enrique Fernández Martínez | 2,000 | – | – |
| Cachorros de León | León, Guanajuato | CODE Las Joyas | 1,000 | – | Fut-Car |
| Empresarios del Rincón | Purísima del Rincón, Guanajuato | Unidad Deportiva de Purísima | 1,000 | – | Real Olmeca Sport |
| Jerez | Jerez, Zacatecas | Unidad Deportiva Solidaridad | 1,000 | – | FC Zacatecas |
| Mineros de Zacatecas | Zacatecas, Zacatecas | Universitario Deportiva Guadalupe | 1,000 | Mineros de Zacatecas | – |
| Pabellón | Pabellón de Arteaga, Aguascalientes | Luis Guzmán | 2,000 | – | – |
| León GEN | Lagos de Moreno, Jalisco | Complejo Deportivo GEN | 2,000 | León | – |
| Tuzos UAZ | Zacatecas, Zacatecas | Universitario Unidad Deportiva Norte | 5,000 | Tuzos UAZ | – |
| Zapateros de León | León, Guanajuato | Luis "Chino" Estrada | 500 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Atlético Leonés | 18 | 12 | 3 | 3 | 45 | 16 | +29 | 42 | Advance to Liguilla de Ascenso |
| 2 | Tuzos UAZ | 18 | 12 | 4 | 2 | 61 | 21 | +40 | 41 | Advance to Liguilla de Ascenso |
| 3 | Mineros de Zacatecas | 18 | 10 | 2 | 6 | 43 | 29 | +14 | 34 | Advance to Liguilla de No Ascenso |
| 4 | Cachorros de León | 18 | 9 | 4 | 5 | 35 | 21 | +14 | 31 | Advance to Liguilla de Ascenso |
| 5 | Jerez | 18 | 5 | 8 | 5 | 26 | 24 | +2 | 29 | |
| 6 | Pabellón | 18 | 7 | 4 | 7 | 21 | 18 | +3 | 28 | |
| 7 | Zapateros de León | 18 | 7 | 3 | 8 | 27 | 30 | −3 | 24 | |
| 8 | Alacranes de Durango | 18 | 5 | 2 | 11 | 30 | 36 | −6 | 18 | |
| 9 | Empresarios del Rincón | 18 | 3 | 2 | 13 | 12 | 41 | −29 | 12 | |
| 10 | León GEN | 18 | 3 | 2 | 13 | 17 | 81 | −64 | 11 | |

## Group 12

Group with 12 teams from Jalisco.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Acatlán | Zapotlanejo, Jalisco | Miguel Hidalgo | 1,500 | – | – |
| Agaveros | Tlajomulco de Zúñiga, Jalisco | Campos Elite | 1,000 | – | – |
| Alteños Acatic | Acatic, Jalisco | Unidad Deportiva Acatic | 1,000 | Tepatitlán | – |
| Aves Blancas | Tepatitlán de Morelos, Jalisco | Corredor Industrial | 1,200 | – | – |
| Ayense | Ayotlán, Jalisco | Chino Rivas | 4,000 | – | – |
| Gorilas de Juanacatlán | Juanacatlán, Jalisco | Club Juanacatlán | 500 | – | – |
| Nacional | Zapopan, Jalisco | Club Deportivo Imperio | 500 | – | – |
| Oro | Tonalá, Jalisco | Unidad Deportiva Revolución Mexicana | 3,000 | – | – |
| Salamanca | Yahualica, Jalisco | Las Ánimas | 8,500 | – | – |
| Tapatíos Soccer | Zapopan, Jalisco | Club Deportivo Aviña | 1,000 | – | – |
| Tepatitlán | Tepatitlán de Morelos, Jalisco | Gregorio "Tepa" Gómez | 8,085 | Tepatitlán | – |
| Tornados Tlaquepaque | Tlaquepaque, Jalisco | Complejo Deportivo Maracaná | 500 | – | Atlético Cocula |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Ayense | 22 | 15 | 6 | 1 | 49 | 16 | +33 | 54 | Advance to Liguilla de Ascenso |
| 2 | Gorilas de Juanacatlán | 22 | 13 | 8 | 1 | 38 | 13 | +25 | 51 | Advance to Liguilla de Ascenso |
| 3 | Tapatíos Soccer | 22 | 13 | 4 | 5 | 50 | 22 | +28 | 47 | Advance to Liguilla de Ascenso |
| 4 | Tepatitlán | 22 | 11 | 5 | 6 | 40 | 24 | +16 | 40 | Advance to Liguilla de Ascenso |
| 5 | Aves Blancas | 22 | 7 | 8 | 7 | 31 | 27 | +4 | 34 | |
| 6 | Agaveros | 22 | 10 | 3 | 9 | 38 | 31 | +7 | 33 | |
| 7 | Acatlán | 22 | 7 | 6 | 9 | 29 | 31 | −2 | 30 | |
| 8 | Oro | 22 | 6 | 6 | 10 | 22 | 29 | −7 | 28 | |
| 9 | Salamanca | 22 | 7 | 5 | 10 | 31 | 40 | −9 | 28 | |
| 10 | Tornados de Tlaquepaque | 22 | 5 | 6 | 11 | 15 | 37 | −22 | 25 | |
| 11 | Alteños Acatic | 22 | 6 | 2 | 14 | 30 | 50 | −20 | 20 | |
| 12 | Nacional | 22 | 0 | 5 | 17 | 11 | 64 | −53 | 6 | |

## Group 13

Group with 11 teams from Jalisco.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Caja Oblatos | Tlaquepaque, Jalisco | Club Vaqueros | 1,000 | – | – |
| Catedráticos Elite | Etzatlán, Jalisco | Unidad Deportiva Etzatlán | 1,000 | Catedráticos Elite | – |
| Deportivo Cihuatlán | Cihuatlán, Jalisco | El Llanito | 5,000 | – | – |
| Deportivo Cimagol | Tlaquepaque, Jalisco | Club Deportivo del Valle | 1,000 | – | – |
| SD Eibar Escuela México | Jocotepec, Jalisco | Municipal de Jocotepec | 2,500 | Eibar | – |
| Gallos Viejos | Zapopan, Jalisco | Club Pumas Tesistán | 1,000 | – | – |
| Leones Negros UdeG | Zapopan, Jalisco | Club Deportivo U. de G. | 3,000 | Leones Negros UdeG | – |
| Mazorqueros | Ciudad Guzmán, Jalisco | Municipal Santa Rosa | 3,500 | Mazorqueros | – |
| Real Ánimas de Sayula | Sayula, Jalisco | Gustavo Díaz Ordaz | 4,000 | – | – |
| River Plate Escuela Jalisco | Tonalá, Jalisco | Unidad Deportiva Revolución Mexicana | 3,000 | River Plate | – |
| Tecos | Zapopan, Jalisco | Tres de Marzo | 18,779 | Tecos | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Mazorqueros | 20 | 14 | 4 | 2 | 51 | 13 | +38 | 50 | Advance to Liguilla de Ascenso |
| 2 | Real Ánimas de Sayula | 20 | 13 | 4 | 3 | 47 | 21 | +26 | 46 | Advance to Liguilla de Ascenso |
| 3 | Catedráticos Elite | 20 | 12 | 5 | 3 | 38 | 22 | +16 | 43 | Advance to Liguilla de Ascenso |
| 4 | Leones Negros UdeG | 20 | 11 | 3 | 6 | 42 | 17 | +25 | 38 | Advance to Liguilla de No Ascenso |
| 5 | Tecos | 20 | 10 | 3 | 7 | 35 | 24 | +11 | 34 | Advance to Liguilla de No Ascenso |
| 6 | Caja Oblatos | 20 | 6 | 6 | 8 | 34 | 35 | −1 | 24 | |
| 7 | River Plate Escuela Jalisco | 20 | 6 | 5 | 9 | 33 | 34 | −1 | 27 | Advance to Liguilla de No Ascenso |
| 8 | Gallos Viejos | 20 | 7 | 5 | 8 | 32 | 36 | −4 | 26 | |
| 9 | Deportivo Cihuatlán | 20 | 5 | 3 | 12 | 18 | 39 | −21 | 21 | |
| 10 | SD Eibar Escuela México | 20 | 4 | 5 | 11 | 17 | 42 | −25 | 19 | |
| 11 | Deportivo Cimagol | 20 | 0 | 1 | 19 | 7 | 71 | −64 | 2 | |

## Group 14

Group with 12 teams from Jalisco, Nayarit and Sinaloa. NOTE: Camaroneros de Escuinapa participated in the first half of the season, but withdrew from the league in February 2022 due to unknown reasons.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Atlético Nayarit | Xalisco, Nayarit | Olímpico Santa Teresita | 4,000 | – | – |
| Camaroneros de Escuinapa | Tonalá, Jalisco | Unidad Deportiva Revolución Mexicana | 3,000 | – | – |
| CEFO–ALR | Ameca, Jalisco | Núcleo Deportivo y de Espectáculos Ameca | 7,000 | Tecos | – |
| Coras | Tepic, Nayarit | Olímpico Santa Teresita | 4,000 | Coras | – |
| Deportivo Tala | Tala, Jalisco | Centro Deportivo y Cultural 24 de Marzo | 3,000 | – | Volcanes de Colima |
| Diablos Tesistán | Zapopan, Jalisco | Club Diablos Tesistán | 1,000 | – | – |
| Dorados de Sinaloa | Navolato, Sinaloa | Juventud | 2,000 | Dorados de Sinaloa | – |
| Fénix CFAR | San Isidro Mazatepec, Jalisco | La Fortaleza | 1,000 | – | – |
| Legado del Centenario | Ixtlahuacán de los Membrillos, Jalisco | Unidad Deportiva Ixtlahuacán de los Membrillos | 1,000 | – | – |
| Puerto Vallarta | Puerto Vallarta, Jalisco | Ejidal La Preciosa | 2,000 | – | – |
| Tigres de Alica | Xalisco, Nayarit | Unidad Deportiva AFEN "Dos Toños" | 2,000 | – | – |
| Xalisco | Xalisco, Nayarit | Unidad Deportiva AFEN "Dos Toños" | 2,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Diablos Tesistán | 20 | 13 | 6 | 1 | 45 | 17 | +28 | 48 | Advance to Liguilla de Ascenso |
| 2 | Dorados de Sinaloa | 20 | 14 | 2 | 4 | 43 | 15 | +28 | 45 | Advance to Liguilla de No Ascenso |
| 3 | Deportivo Tala | 20 | 11 | 5 | 4 | 47 | 29 | +18 | 41 | Advance to Liguilla de Ascenso |
| 4 | Legado del Centenario | 20 | 11 | 4 | 5 | 46 | 19 | +27 | 39 | Advance to Liguilla de Ascenso |
| 5 | Coras | 20 | 10 | 4 | 6 | 40 | 30 | +10 | 37 | Advance to Liguilla de No Ascenso |
| 6 | Tigres de Alica | 20 | 10 | 3 | 7 | 28 | 26 | +2 | 36 | |
| 7 | Xalisco | 20 | 8 | 2 | 10 | 28 | 35 | −7 | 28 | |
| 8 | Fénix CFAR | 20 | 5 | 4 | 11 | 26 | 50 | −24 | 19 | |
| 9 | Puerto Vallarta | 20 | 4 | 3 | 13 | 20 | 44 | −24 | 17 | |
| 10 | CEFO–ALR | 20 | 2 | 4 | 14 | 13 | 40 | −27 | 11 | |
| 11 | Atlético Nayarit | 20 | 1 | 5 | 14 | 11 | 42 | −31 | 9 | |

## Group 15

Group with 16 teams from Coahuila, Nuevo León, San Luis Potosí and Tamaulipas. NOTE: Bravos de Nuevo Laredo participated in the first half of the season, but withdrew from the league in January 2022 due to financial problems.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Bravos de Nuevo Laredo | Nuevo Laredo, Tamaulipas | Unidad Deportiva Benito Juárez | 5,000 | – | – |
| Cadereyta | Cadereyta, Nuevo León | Clemente Salinas Netro | 1,000 | – | – |
| Correcaminos UAT | Ciudad Victoria, Tamaulipas | Profesor Eugenio Alvizo Porras | 5,000 | Correcaminos UAT | – |
| FCD Bulls Santiago | Santiago, Nuevo León | FCD El Barrial | 570 | FC Dallas | – |
| Gallos Nuevo León | San Nicolás de los Garza, Nuevo León | Parque Deportivo Mario J. Montemayor | 1,000 | – | – |
| Garzas Blancas | Axtla de Terrazas, San Luis Potosí | Garzas Blancas | 1,000 | – | – |
| Gavilanes de Matamoros | Matamoros, Tamaulipas | El Hogar | 22,000 | Gavilanes de Matamoros | Ho Gar H. Matamoros |
| Guerreros Reynosa | Reynosa, Tamaulipas | José María Leal Gutiérrez | 3,000 | – | – |
| Halcones de Saltillo | Saltillo, Coahuila | Olímpico Francisco I. Madero | 7,000 | – | San Isidro Laguna |
| Irritilas | San Pedro, Coahuila | Quinta Ximena | 1,000 | – | – |
| Mineros Reynosa | Reynosa, Tamaulipas | Unidad Deportiva Solidaridad | 20,000 | Mineros de Zacatecas | Deportivo Soria |
| Orgullo Surtam | Tampico, Tamaulipas | Unidad Deportiva Tampico | 1,500 | – | – |
| Real San Cosme | Monterrey, Nuevo León | Ciudad Deportiva Churubusco | 1,000 | – | – |
| Regios | Monterrey, Nuevo León | Ciudad Deportiva Churubusco | 1,000 | – | – |
| Saltillo Soccer | Saltillo, Coahuila | Olímpico Francisco I. Madero | 7,000 | Saltillo | – |
| San Nicolás | San Nicolás de los Garza, Nuevo León | Unidad Deportiva Oriente | 1,000 | – | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Saltillo Soccer | 28 | 25 | 3 | 0 | 71 | 14 | +57 | 79 | Advance to Liguilla de Ascenso |
| 2 | FCD Bulls Santiago | 28 | 17 | 6 | 5 | 51 | 20 | +31 | 62 | Advance to Liguilla de Ascenso |
| 3 | Orgullo Surtam | 28 | 19 | 4 | 5 | 60 | 26 | +34 | 63 | Advance to Liguilla de Ascenso |
| 4 | Cadereyta | 28 | 19 | 2 | 7 | 69 | 28 | +41 | 61 | Advance to Liguilla de Ascenso |
| 5 | Correcaminos UAT | 28 | 13 | 6 | 9 | 38 | 40 | −2 | 51 | Advance to Liguilla de No Ascenso |
| 6 | Mineros Reynosa | 28 | 14 | 5 | 9 | 53 | 40 | +13 | 50 | |
| 7 | Irritilas | 28 | 15 | 3 | 10 | 59 | 28 | +31 | 49 | |
| 8 | Garzas Blancas | 28 | 9 | 5 | 14 | 38 | 51 | −13 | 33 | |
| 9 | Guerreros Reynosa | 28 | 8 | 5 | 15 | 23 | 43 | −20 | 32 | |
| 10 | Gavilanes de Matamoros | 28 | 6 | 9 | 13 | 42 | 55 | −13 | 31 | |
| 11 | Regios | 28 | 6 | 8 | 14 | 26 | 50 | −24 | 31 | |
| 12 | Halcones de Saltillo | 28 | 6 | 6 | 16 | 24 | 65 | −41 | 27 | |
| 13 | Gallos Nuevo León | 28 | 7 | 4 | 17 | 42 | 63 | −21 | 25 | |
| 14 | San Nicolás | 28 | 6 | 4 | 18 | 26 | 54 | −28 | 23 | |
| 15 | Real San Cosme | 28 | 2 | 6 | 20 | 27 | 72 | −45 | 14 | |

## Group 16

Group with 11 teams from Baja California, Chihuahua and Sonora.

### Teams

| Team | City | Home ground | Capacity | Affiliate | Official Name |
| Atlético Nogales | Nogales, Sonora | Jesús Jegar García | 2,000 | – | Huatabampo |
| Búhos UNISON | Hermosillo, Sonora | Miguel Castro Servín | 4,000 | – | – |
| Cachanillas | Mexicali, Baja California | Eduardo "Boticas" Pérez | 2,000 | – | – |
| CEPROFFA | Ciudad Juárez, Chihuahua | CEPROFFA | 1,000 | – | – |
| Cimarrones de Sonora | Hermosillo, Sonora | Héroe de Nacozari | 18,747 | Cimarrones de Sonora | – |
| Cobras Fut Premier | Ciudad Juárez, Chihuahua | 20 de Noviembre | 2,500 | – | – |
| Etchojoa | Etchojoa, Sonora | Trigueros | 1,500 | – | – |
| Guaymas | Guaymas, Sonora | Unidad Deportiva Julio Alfonso | 3,000 | – | – |
| La Tribu de Ciudad Juárez | Ciudad Juárez, Chihuahua | Complejo La Tribu | 500 | – | – |
| Real Magari | Chihuahua, Chihuahua | Olímpico Ciudad Deportiva | 4,000 | – | – |
| Xolos Hermosillo | Hermosillo, Sonora | Cancha Aarón Gamal Aguirre Fimbres | 1,000 | Tijuana | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | La Tribu de Ciudad Juárez | 20 | 11 | 9 | 0 | 59 | 22 | +37 | 46 | Advance to Liguilla de Ascenso |
| 2 | Cimarrones de Sonora | 20 | 12 | 6 | 2 | 38 | 12 | +26 | 45 | Advance to Liguilla de No Ascenso |
| 3 | CEPROFFA | 20 | 11 | 4 | 5 | 34 | 22 | +12 | 40 | Advance to Liguilla de Ascenso |
| 4 | Cachanillas | 20 | 9 | 5 | 6 | 30 | 29 | +1 | 37 | |
| 5 | Etchojoa | 20 | 10 | 5 | 5 | 36 | 29 | +7 | 36 | |
| 6 | Xolos Hermosillo | 20 | 7 | 5 | 8 | 28 | 27 | +1 | 28 | Advance to Liguilla de No Ascenso |
| 7 | Búhos UNISON | 20 | 6 | 6 | 8 | 23 | 30 | −7 | 26 | |
| 8 | Real Magari | 20 | 6 | 3 | 11 | 18 | 29 | −11 | 23 | |
| 9 | Cobras Fut Premier | 20 | 6 | 4 | 10 | 15 | 35 | −20 | 23 | |
| 10 | Guaymas | 20 | 3 | 4 | 13 | 15 | 34 | −19 | 15 | |
| 11 | Atlético Nogales | 20 | 3 | 1 | 16 | 10 | 37 | −27 | 11 | |

## Group 17

Group with 4 teams from Baja California.

### Teams

| Team | City | Home ground | Capacity | Affiliate |
| 40 Grados MXL | Mexicali, Baja California | Unidad Deportiva Baja California | 1,000 | – |
| Gladiadores Tijuana | Tijuana, Baja California | CREA Tijuana | 10,000 | – |
| London | Rosarito Beach, Baja California | Campo Emiliano Zapata | 500 | – |
| Rosarito | Rosarito Beach, Baja California | Andrés Luna | 2,000 | – |

### League table

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | London | 24 | 16 | 3 | 5 | 52 | 24 | +28 | 53 | Advance to Liguilla de Ascenso |
| 2 | Gladiadores Tijuana | 24 | 14 | 5 | 5 | 48 | 25 | +23 | 49 | |
| 3 | 40 Grados MXL | 24 | 8 | 5 | 11 | 34 | 45 | −11 | 32 | |
| 4 | Rosarito | 24 | 1 | 5 | 18 | 22 | 62 | −40 | 9 | |

## Promotion Play–offs

The Promotion Play–offs will consist of seven phases. Classify 64 teams, the number varies according to the number of teams in each group, being between three and eight clubs per group. The country will be divided into two zones: South Zone (Groups 1 to 8) and North Zone (Groups 9 to 17). Eliminations will be held according to the average obtained by each team, being ordered from best to worst by their percentage throughout the season.
As of 2020–21 season, the names of the knockout stages were modified as follows: Round of 32, Round of 16, Quarter-finals, Semifinals, Zone Final and Final, this as a consequence of the division of the country into two zones, for so the teams only face clubs from the same region until the final series.

### Round of 32

The first legs were played on 27 and 28 April, and the second legs were played on 30 April and 1 May 2022.

#### South Zone

| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Muxes | 6–2 | Pioneros Junior | 0–1 | 6–1 |
| Deportiva Venados | 5–2 | Álamos | 2–2 | 3–0 |
| CDM | 2–2 (1–3) (p.) | Corsarios de Campeche | 1–1 | 1–1 |
| Poza Rica | 4–1 | UNICACH | 2–1 | 2–0 |
| Chilpancingo | 4–1 | Selva Cañera | 1–1 | 3–0 |
| Estudiantes | 5–0 | Tantoyuca | 2–0 | 3–0 |
| Sime Soccer | 1–0 | Universidad del Sureste | 1–0 | 0–0 |
| Cuervos Blancos | 3–0 | CARSAF | 2–0 | 1–0 |
| Guerreros DDios | 1–0 | Aragón | 1–0 | 0–0 |
| Tigres Yautepec | 2–4 | Inter Playa del Carmen | 1–1 | 1–3 |
| Lechuzas UPGCH | (p.) 2–2 (4–1) | Héroes de Zaci | 2–0 | 0–2 |
| Caballeros de Córdoba | 3–1 | Unión | 0–0 | 3–1 |
| Yautepec | 4–4 (2–4) (p.) | Chilangos | 1–4 | 3–0 |
| Licántropos | 6–2 | Loyalty | 2–2 | 4–0 |
| Proyecto México Soccer | 1–1 (1–3) (p.) | Cruz Azul Lagunas | 0–0 | 1–1 |
| Cuervos de Silver Soccer | 0–3 | Delfines UGM | 0–2 | 0–1 |

#### North Zone

| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Saltillo Soccer | 2–2 (4–5) (p.) | Cachorros de León | 0–2 | 2–0 |
| Titanes de Querétaro | 2–1 | Tepatitlán | 0–0 | 2–1 |
| Aguacateros de Peribán | 6–2 | Legado del Centenario | 2–2 | 4–0 |
| Faraones de Texcoco | 2–1 | Atlético Pachuca | 1–1 | 1–0 |
| Mazorqueros | 4–2 | CEPROFFA | 2–1 | 2–1 |
| Petroleros Querétaro | (p.) 3–3 (5–3) | Deportivo Tala | 2–1 | 1–2 |
| Ayense | 4–3 | Furia Azul | 1–2 | 3–1 |
| Diablos Tesistán | 2–3 | Sk Sport Street Soccer | 1–1 | 1–2 |
| Bombarderos de Tecámac | 4–1 | H2O Purépechas | 1–0 | 3–1 |
| Tuzos Pachuca | 4–2 | Tapatíos Soccer | 1–0 | 3–2 |
| Atlético Leonés | 2–1 | Catedráticos Elite | 0–1 | 2–0 |
| Gorilas de Juanacatlán | 4–3 | Michoacán F.C. | 3–1 | 1–2 |
| La Tribu de Ciudad Juárez | 2–0 | Cadereyta | 0–0 | 2–0 |
| Real Ánimas de Sayula | 3–1 | London | 1–1 | 2–0 |
| Estudiantes de Querétaro | 1–6 | FCD Bulls de Santiago | 1–4 | 0–2 |
| Tuzos UAZ | 11–3 | Orgullo Surtam | 3–3 | 8–0 |

### Round of 16

The first legs were played on 4 and 5 May, and the second legs will be played on 7 and 8 May 2022.

#### South Zone

| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Muxes | 6–1 | Corsarios de Campeche | 1–1 | 5–0 |
| Deportiva Venados | 3–1 | Inter Playa del Carmen | 1–0 | 2–1 |
| Poza Rica | 7–2 | Chilangos | 3–2 | 4–0 |
| Chilpancingo | 4–2 | Cruz Azul Lagunas | 1–1 | 3–1 |
| Estudiantes | 1–2 | Delfines UGM | 0–2 | 1–0 |
| Sime Soccer | 3–2 | Licántropos | 2–2 | 1–0 |
| Cuervos Blancos | 1–2 | Caballeros de Córdoba | 0–0 | 1–2 |
| Guerreros DDios | 3–2 | Lechuzas UPGCH | 1–1 | 2–1 |

#### North Zone

| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Titanes de Querétaro | 7–0 | Cachorros de León | 4–0 | 3–0 |
| Aguacateros de Peribán | 2–4 | Sk Sport Street Soccer | 0–1 | 2–3 |
| Faraones de Texcoco | 3–4 | FCD Bulls de Santiago | 2–2 | 1–2 |
| Mazorqueros | 6–3 | Tuzos UAZ | 2–2 | 4–1 |
| Petroleros Querétaro | 4–6 | Real Ánimas de Sayula | 0–3 | 4–3 |
| Ayense | 2–2 (1–3) (p.) | La Tribu de Ciudad Juárez | 1–2 | 1–0 |
| Bombarderos de Tecámac | 1–3 | Gorilas de Juanacatlán | 0–2 | 1–1 |
| Tuzos Pachuca | 3–4 | Atlético Leonés | 1–1 | 2–3 |

### Final stage

| Zone Quarter–finals | Zone Quarter–finals | Zone Quarter–finals | Zone Quarter–finals | Zone Quarter–finals | Zone Semi–finals | Zone Semi–finals | Zone Semi–finals | Zone Semi–finals | Zone Semi–finals | Zone finals | Zone finals | Zone finals | Zone finals | Zone finals | | National final | National final | National final | |
| 1 | Deportiva Venados | 1 | 2 | 3 | | | | | | | | | | | | | | | |
| 16 | Caballeros de Córdoba | 1 | 0 | 1 | | | | | | | | | | | | | | | |
| 16 | Caballeros de Córdoba | 1 | 0 | 1 | Deportiva Venados | Deportiva Venados | 1 | 3 | 4 | | | | | | | | | | |
| | | | | | Delfines UGM | Delfines UGM | 1 | 0 | 1 | | | | | | | | | | |
| 8 | Muxes | 1 | 0 | 1 (3) | Delfines UGM | Delfines UGM | 1 | 0 | 1 | | | | | | | | | | |
| 9 | Delfines UGM (p.) | 1 | 0 | 1 (5) | | | | | | | | | | | | | | | |
| 9 | Delfines UGM (p.) | 1 | 0 | 1 (5) | | | | | | Deportiva Venados | Deportiva Venados | 1 | 2 | 3 | | | | | |
| | | | | | | | | | | Chilpancingo | Chilpancingo | 1 | 1 | 2 | | | | | |
| 5 | Chilpancingo | 1 | 4 | 5 | | | | | | | | | | | Chilpancingo | Chilpancingo | 1 | 1 | 2 | | | |
| 12 | Sime Soccer | 1 | 1 | 2 | | | | | | | | | | | | | | | |
| 12 | Sime Soccer | 1 | 1 | 2 | Chilpancingo | Chilpancingo | 1 | 2 | 3 | | | | | | | | | | |
| | | | | | Guerreros DDios | Guerreros DDios | 0 | 0 | 0 | | | | | | | | | | |
| 4 | Poza Rica | 1 | 2 | 3 (2) | Guerreros DDios | Guerreros DDios | 0 | 0 | 0 | | | | | | | | | | |
| 13 | Guerreros DDios (p.) | 3 | 0 | 3 (3) | | | | | | | | | | | | | | | |
| 13 | Guerreros DDios (p.) | 3 | 0 | 3 (3) | | | | | | | | | | | | Deportiva Venados | Deportiva Venados | 0 | |
| | | | | | | | | | | | | | | | | Mazorqueros | Mazorqueros | 1 | |
| 6 | Mazorqueros (p.) | 1 | 0 | 1 (5) | | | | | | | | | | | | | | | | Mazorqueros | Mazorqueros | 1 |
| 11 | FCD Bulls de Santiago | 1 | 0 | 1 (4) | | | | | | | | | | | | | | | |
| 11 | FCD Bulls de Santiago | 1 | 0 | 1 (4) | Mazorqueros | Mazorqueros | 1 | 2 | 3 | | | | | | | | | | |
| | | | | | Gorilas de Juanacatlán | Gorilas de Juanacatlán | 0 | 2 | 2 | | | | | | | | | | |
| 3 | Gorilas de Juanacatlán | 1 | 2 | 3 | Gorilas de Juanacatlán | Gorilas de Juanacatlán | 0 | 2 | 2 | | | | | | | | | | |
| 14 | La Tribu de Ciudad Juárez | 1 | 0 | 1 | | | | | | | | | | | | | | | |
| 14 | La Tribu de Ciudad Juárez | 1 | 0 | 1 | | | | | | Mazorqueros | Mazorqueros | 3 | 2 | 5 | | | | | |
| | | | | | | | | | | Real Ánimas de Sayula | Real Ánimas de Sayula | 2 | 2 | 4 | | | | | |
| 7 | Titanes de Querétaro (p.) | 1 | 1 | 2 (6) | | | | | | | | | | | Real Ánimas de Sayula | Real Ánimas de Sayula | 2 | 2 | 4 | | | |
| 10 | Sk Sport Street Soccer | 0 | 2 | 2 (5) | | | | | | | | | | | | | | | |
| 10 | Sk Sport Street Soccer | 0 | 2 | 2 (5) | Titanes de Querétaro | Titanes de Querétaro | 0 | 3 | 3 (9) | | | | | | | | | | |
| | | | | | Real Ánimas de Sayula (p.) | Real Ánimas de Sayula (p.) | 2 | 1 | 3 (10) | | | | | | | | | | |
| 2 | Atlético Leonés | 1 | 0 | 1 (8) | Real Ánimas de Sayula (p.) | Real Ánimas de Sayula (p.) | 2 | 1 | 3 (10) | | | | | | | | | | |
| 15 | Real Ánimas de Sayula (p.) | 1 | 0 | 1 (9) | | | | | | | | | | | | | | | |

#### Zone Quarter–finals

The first legs were played on 11 and 12 May, and the second legs were played on 14 and 15 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Muxes | 1–1 (3–5) (p.) | Delfines UGM | 1–1 | 0–0 |
| Deportiva Venados | 3–1 | Caballeros de Córdoba | 1–1 | 2–0 |
| Poza Rica | 3–3 (2–3) (p.) | Guerreros DDios | 1–3 | 2–0 |
| Chilpancingo | 5–2 | Sime Soccer | 1–1 | 4–1 |
| Titanes de Querétaro | (p.) 2–2 (6–5) | Sk Sport Street Soccer | 1–0 | 1–2 |
| Mazorqueros | (p.) 1–1 (5–4) | FCD Bulls de Santiago | 1–1 | 0–0 |
| Atlético Leonés | 1–1 (8–9) (p.) | Real Ánimas de Sayula | 1–1 | 0–0 |
| Gorilas de Juanacatlán | 3–1 | La Tribu de Ciudad Juárez | 1–1 | 2–0 |

##### Second leg
#### Zone Semi–finals

The first legs were played on 18 May, and the second legs were played on 21 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Deportiva Venados | 4–1 | Delfines UGM | 1–1 | 3–0 |
| Chilpancingo | 3–0 | Guerreros DDios | 1–0 | 2–0 |
| Titanes de Querétaro | 3–3 (9–10) (p.) | Real Ánimas de Sayula | 0–2 | 3–1 |
| Mazorqueros | 3–2 | Gorilas de Juanacatlán | 1–0 | 2–2 |

##### Second leg
#### Zone Finals

The first legs will be played on 25 and 26 May, and the second legs will be played on 28 and 29 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Deportiva Venados | 3–2 | Chilpancingo | 1–1 | 2–1 |
| Mazorqueros | 5–4 | Real Ánimas de Sayula | 3–2 | 2–2 |

##### Second leg
#### National runner–ups play–off

The two losing clubs in the zone finals played a game to win a place in the Liga Premier – Serie B. The match was played on 1 June 2022.
| Team 1 | Score | Team 2 |
| Chilpancingo (p.) | 3–3 (8–7) | Real Ánimas de Sayula |

#### National Final

The two winning clubs from the zone finals played a match to determine the league champion. The match was played on 3 June 2022 at the Estadio Ciudad de los Deportes, Mexico City.
| Team 1 | Score | Team 2 |
| Deportiva Venados | 0–1 | Mazorqueros |
* 2021–22 winners
* Mazorqueros 1st title

## Reserve and Development Teams

Each season a table is created among those teams that don't have the right to promote, because they are considered as reserve teams for teams that play in Liga MX, Liga de Expansión and Liga Premier or are independent teams that have requested not to participate for the Promotion due to the fact that they are footballers development projects. The ranking order is determined through the "quotient", which is obtained by dividing the points obtained between the disputed matches, being ordered from highest to lowest.

### Table

| P | Team | Pts | G | Pts/G | GD |
| 1 | Toluca | 54 | 22 | 2.45 | +29 |
| 2 | Juárez | 57 | 24 | 2.38 | +43 |
| 3 | Dorados de Sinaloa | 45 | 20 | 2.25 | +28 |
| 4 | Cimarrones de Sonora | 45 | 20 | 2.25 | +27 |
| 5 | Alebrijes de Oaxaca | 43 | 20 | 2.15 | +22 |
| 6 | Cantera Venados | 42 | 20 | 2.10 | +14 |
| 7 | El Árbol Santa Fe | 43 | 22 | 1.95 | +17 |
| 8 | Leones Negros UdeG | 38 | 20 | 1.90 | +25 |
| 9 | Mineros de Zacatecas | 34 | 18 | 1.89 | +14 |
| 10 | Coras F.C. | 37 | 20 | 1.85 | +10 |
| 11 | Correcaminos UAT | 51 | 28 | 1.82 | –2 |
| 12 | Tecos | 34 | 20 | 1.70 | +12 |
| 13 | Correcaminos Tequisquiapan | 47 | 28 | 1.68 | +23 |
| 14 | Leones | 37 | 24 | 1.54 | +3 |
| 15 | Xolos Hermosillo | 28 | 20 | 1.40 | +1 |
| 16 | River Plate Escuela Jalisco | 27 | 20 | 1.35 | –1 |
| 17 | León Izcalli | 37 | 28 | 1.32 | 0 |
| 18 | MACA | 29 | 22 | 1.32 | –2 |
| 19 | Búhos UNISON | 26 | 20 | 1.30 | –7 |
| 20 | Celaya | 36 | 28 | 1.29 | –14 |
| 21 | Salamanca | 28 | 22 | 1.27 | –9 |
| 22 | Atlético Toltecas | 38 | 30 | 1.27 | –11 |
| 23 | Guerreros Tlaxcala | 35 | 28 | 1.25 | –21 |
| 24 | Mineros Querétaro | 34 | 28 | 1.21 | –27 |
| 25 | La Piedad Querétaro | 32 | 28 | 1.14 | –22 |
| 26 | Regios | 31 | 28 | 1.11 | –24 |
| 27 | Alacranes de Durango | 18 | 18 | 1.00 | –6 |
| 28 | Ciervos | 22 | 22 | 1.00 | –9 |
| 29 | SD Eibar Escuela México | 19 | 20 | 0.95 | –25 |
| 30 | Dongu | 26 | 28 | 0.93 | –27 |
| 31 | Alteños Acatic | 20 | 22 | 0.91 | –20 |
| 32 | Gallos Nuevo León | 25 | 28 | 0.89 | –21 |
| 33 | Atlético Chavinda | 15 | 18 | 0.83 | –21 |
| 34 | Inter de Querétaro | 17 | 28 | 0.61 | –33 |
| 35 | Atlético Cadereyta | 17 | 28 | 0.61 | –44 |
| 36 | León GEN | 11 | 18 | 0.61 | –64 |
| 37 | Águilas Talpa | 13 | 22 | 0.59 | –25 |
| 38 | CEFO-ALR | 11 | 20 | 0.55 | –27 |
| 39 | Atlético Nogales | 11 | 20 | 0.55 | –27 |
| 40 | Atlético Nayarit | 9 | 20 | 0.45 | –31 |
| 41 | Camaleones | 9 | 24 | 0.38 | –47 |
| 42 | Guerreros Aztecas IAFE | 11 | 30 | 0.37 | –80 |
| 43 | Yucatán | 6 | 20 | 0.30 | –39 |
Last updated: April 23, 2022 Source: Liga TDP P = Position; G = Games played; Pts = Points; Pts/G = Ratio of points to games played; GD = Goal difference

### Play–offs

| Round of 16 | Round of 16 | Round of 16 | Round of 16 | Round of 16 | Quarter–finals | Quarter–finals | Quarter–finals | Quarter–finals | Quarter–finals | Semi–finals | Semi–finals | Semi–finals | Semi–finals | Semi–finals | | Final | Final | Final | Final | Final |
| 4 | Cimarrones de Sonora (w/o) | 0 | 1 | 1 | | | | | | | | | | | | | | | | |
| 13 | Correcaminos Tequisquiapan | 0 | 0 | 0 | | | | | | | | | | | | | | | | |
| 13 | Correcaminos Tequisquiapan | 0 | 0 | 0 | 4 | Cimarrones de Sonora | 2 | 6 | 8 | | | | | | | | | | | |
| | | | | | 6 | Cantera Venados | 0 | 0 | 0 | | | | | | | | | | | |
| 6 | Cantera Venados | 2 | 2 | 4 | 6 | Cantera Venados | 0 | 0 | 0 | | | | | | | | | | | |
| 11 | Correcaminos UAT | 1 | 1 | 2 | | | | | | | | | | | | | | | | |
| 11 | Correcaminos UAT | 1 | 1 | 2 | | | | | | 4 | Cimarrones de Sonora | 0 | 1 | 1 | | | | | | |
| | | | | | | | | | | 10 | Coras | 0 | 0 | 0 | | | | | | |
| 2 | Juárez | 2 | 2 | 4 | | | | | | | | | | | 10 | Coras | 0 | 0 | 0 | | | | | | |
| 15 | Xolos Hermosillo | 3 | 0 | 3 | | | | | | | | | | | | | | | | |
| 15 | Xolos Hermosillo | 3 | 0 | 3 | 2 | Juárez | 2 | 3 | 5 (1) | | | | | | | | | | | |
| | | | | | 10 | Coras (p.) | 1 | 4 | 5 (3) | | | | | | | | | | | |
| 7 | El Árbol Santa Fe | 0 | 3 | 3 | 10 | Coras (p.) | 1 | 4 | 5 (3) | | | | | | | | | | | |
| 10 | Coras | 2 | 2 | 4 | | | | | | | | | | | | | | | | |
| 10 | Coras | 2 | 2 | 4 | | | | | | | | | | | | 4 | Cimarrones de Sonora | 0 | 0 | 0 |
| | | | | | | | | | | | | | | | | 12 | Tecos | 1 | 3 | 4 |
| 3 | Dorados de Sinaloa | 0 | 3 | 3 | | | | | | | | | | | | | | | | | 12 | Tecos | 1 | 3 | 4 |
| 14 | Leones | 1 | 0 | 1 | | | | | | | | | | | | | | | | |
| 14 | Leones | 1 | 0 | 1 | 3 | Dorados de Sinaloa | 1 | 3 | 4 | | | | | | | | | | | |
| | | | | | 8 | Leones Negros UdeG | 0 | 0 | 0 | | | | | | | | | | | |
| 8 | Leones Negros UdeG | 2 | 1 | 3 | 8 | Leones Negros UdeG | 0 | 0 | 0 | | | | | | | | | | | |
| 9 | Mineros de Zacatecas | 0 | 1 | 1 | | | | | | | | | | | | | | | | |
| 9 | Mineros de Zacatecas | 0 | 1 | 1 | | | | | | 3 | Dorados de Sinaloa | 0 | 1 | 1 | | | | | | |
| | | | | | | | | | | 12 | Tecos | 1 | 2 | 3 | | | | | | |
| 1 | Toluca | 1 | 1 | 2 | | | | | | | | | | | 12 | Tecos | 1 | 2 | 3 | | | | | | |
| 16 | River Plate Jalisco | 0 | 1 | 1 | | | | | | | | | | | | | | | | |
| 16 | River Plate Jalisco | 0 | 1 | 1 | 1 | Toluca | 2 | 1 | 3 | | | | | | | | | | | |
| | | | | | 12 | Tecos | 2 | 3 | 5 | | | | | | | | | | | |
| 5 | Alebrijes de Oaxaca | 0 | 1 | 1 (3) | 12 | Tecos | 2 | 3 | 5 | | | | | | | | | | | |
| 12 | Tecos (p.) | 0 | 1 | 1 (4) | | | | | | | | | | | | | | | | |

#### Round of 16

The first legs were played on 27 and 28 April, and the second legs were played on 30 April and 1 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Toluca | 2–1 | River Plate Escuela Jalisco | 1–0 | 1–1 |
| Leones Negros UdeG | 3–1 | Mineros de Zacatecas | 2–0 | 1–1 |
| Cimarrones de Sonora (w/o) | 1–0 | Correcaminos Tequisquiapan | 0–0 | 1–0 |
| Alebrijes de Oaxaca | 1–1 (3–4) (p.) | Tecos | 0–0 | 1–1 |
| Juárez | 4–3 | Xolos Hermosillo | 2–3 | 2–0 |
| El Árbol Santa Fe | 3–4 | Coras | 0–2 | 3–2 |
| Dorados de Sinaloa | 3–0 | Leones | 0–1 | 3–1 |
| Cantera Venados | 4–2 | Correcaminos UAT | 2–1 | 2–1 |

##### Second leg
#### Quarter-finals

The first legs were played on 4 and 5 May, and the second legs were played on 7 and 8 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Toluca | 3–5 | Tecos | 2–2 | 1–3 |
| Cimarrones de Sonora | 8–0 | Cantera Venados | 2–0 | 6–0 |
| Juárez | 5–5 (1–3) (p.) | Coras | 2–1 | 3–4 |
| Dorados de Sinaloa | 4–0 | Leones Negros UdeG | 1–0 | 3–0 |

##### Second leg
#### Semi-finals

The first legs were played on 11 and 12 May, and the second legs were played on 14 and 15 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Dorados de Sinaloa | 1–3 | Tecos | 0–1 | 1–2 |
| Cimarrones de Sonora | 1–0 | Coras | 0–0 | 1–0 |

##### Second leg
#### Final

The first leg were played on 19 May, and the second leg were played on 22 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Cimarrones de Sonora | 0–4 | Tecos | 0–1 | 0–3 |

##### Second leg

* 2021–22 No promotion winners
* Tecos 4th title

## Regular Season statistics
### Top goalscorers

Players sorted first by goals scored, then by last name.
| Rank | Player | Club | Goals |
| 1 | Ángel Alejandro Crespo | Saltillo Soccer | 32 |
| 2 | Juan José González | Tuzos Pachuca | 30 |
| 3 | Anhdony Salinas | Irritilas | 29 |
| 4 | Diego Márquez | Aragón | 26 |
| 4 | William Terrones | Halcones Negros | 26 |
| 6 | Jesús Eduardo Dávila | Chilpancingo | 25 |
| 7 | Víctor Hugo García | Titanes de Querétaro | 23 |
| 7 | Usiel Robles | Hidalguense | 23 |
| 9 | Edson Cibrián | Muxes | 22 |
| 9 | Abisaí Cruz | Tantoyuca | 22 |
Source:Liga TDP