# List of United States senators from Missouri

Missouri was admitted to the Union on August 10, 1821. Its current U.S. senators are Republicans Josh Hawley (class 1, serving since 2019) and Eric Schmitt (class 3, serving since 2023). Francis Cockrell was Missouri's longest-serving senator (1875–1905). Missouri is one of fifteen states alongside California, Colorado, Florida, Georgia, Hawaii, Idaho, Louisiana, Maine, Massachusetts, Minnesota, Nevada, Pennsylvania, South Dakota and Utah to have a younger senior senator and an older junior senator.

## List of senators

| Class 1Class 1 senators belong to the electoral cycle that has recently been contested in 2006, 2012, 2018, and 2024. The next election will be in 2030. | Class 1Class 1 senators belong to the electoral cycle that has recently been contested in 2006, 2012, 2018, and 2024. The next election will be in 2030. | Class 1Class 1 senators belong to the electoral cycle that has recently been contested in 2006, 2012, 2018, and 2024. The next election will be in 2030. | Class 1Class 1 senators belong to the electoral cycle that has recently been contested in 2006, 2012, 2018, and 2024. The next election will be in 2030. | Class 1Class 1 senators belong to the electoral cycle that has recently been contested in 2006, 2012, 2018, and 2024. The next election will be in 2030. | Class 1Class 1 senators belong to the electoral cycle that has recently been contested in 2006, 2012, 2018, and 2024. The next election will be in 2030. | C | Class 3Class 3 senators belong to the electoral cycle that has recently been contested in 2004, 2010, 2016, and 2022. The next election will be in 2028. | Class 3Class 3 senators belong to the electoral cycle that has recently been contested in 2004, 2010, 2016, and 2022. The next election will be in 2028. | Class 3Class 3 senators belong to the electoral cycle that has recently been contested in 2004, 2010, 2016, and 2022. The next election will be in 2028. | Class 3Class 3 senators belong to the electoral cycle that has recently been contested in 2004, 2010, 2016, and 2022. The next election will be in 2028. | Class 3Class 3 senators belong to the electoral cycle that has recently been contested in 2004, 2010, 2016, and 2022. The next election will be in 2028. | Class 3Class 3 senators belong to the electoral cycle that has recently been contested in 2004, 2010, 2016, and 2022. The next election will be in 2028. |
| # | Senator | Party | Dates in office | Electoral history | T | C | T | Electoral history | Dates in office | Party | Senator | # |
| 1 | Thomas Hart Benton | Democratic- Republican | Aug 10, 1821 – Mar 3, 1851 | Elected in 1821. | 1 | 17th | 1 | Elected in 1821. | Aug 10, 1821 – Mar 3, 1831 | Democratic- Republican | David Barton | 1 |
| 1 | Thomas Hart Benton | Democratic- Republican | Aug 10, 1821 – Mar 3, 1851 | Elected in 1821. | 1 | 18th | 1 | Elected in 1821. | Aug 10, 1821 – Mar 3, 1831 | Democratic- Republican | David Barton | 1 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Elected in 1821. | 1 | 19th | 2 | Re-elected in 1825.Lost re-election. | Aug 10, 1821 – Mar 3, 1831 | National Republican | David Barton | 1 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1827. | 2 | 20th | 2 | Re-elected in 1825.Lost re-election. | Aug 10, 1821 – Mar 3, 1831 | National Republican | David Barton | 1 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1827. | 2 | 21st | 2 | Re-elected in 1825.Lost re-election. | Aug 10, 1821 – Mar 3, 1831 | National Republican | David Barton | 1 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1827. | 2 | 22nd | 3 | Elected in 1830.Died. | Mar 4, 1831 – Jun 6, 1833 | Jacksonian | Alexander Buckner | 2 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1833. | 3 | 23rd | 3 | Elected in 1830.Died. | Mar 4, 1831 – Jun 6, 1833 | Jacksonian | Alexander Buckner | 2 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1833. | 3 | 23rd | 3 | | Jun 6, 1833 – Oct 25, 1833 | Vacant | Vacant | Vacant |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1833. | 3 | 23rd | 3 | Appointed to continue Buckner's term.Elected to finish Buckner's term. | Oct 25, 1833 – Oct 3, 1843 | Jacksonian | Lewis F. Linn | 3 |
| 1 | Thomas Hart Benton | Jacksonian | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1833. | 3 | 24th | 3 | Appointed to continue Buckner's term.Elected to finish Buckner's term. | Oct 25, 1833 – Oct 3, 1843 | Jacksonian | Lewis F. Linn | 3 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1833. | 3 | 25th | 4 | Re-elected in 1836. | Oct 25, 1833 – Oct 3, 1843 | Democratic | Lewis F. Linn | 3 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1839. | 4 | 26th | 4 | Re-elected in 1836. | Oct 25, 1833 – Oct 3, 1843 | Democratic | Lewis F. Linn | 3 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1839. | 4 | 27th | 4 | Re-elected in 1836. | Oct 25, 1833 – Oct 3, 1843 | Democratic | Lewis F. Linn | 3 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1839. | 4 | 28th | 5 | Re-elected in 1842.Died. | Oct 25, 1833 – Oct 3, 1843 | Democratic | Lewis F. Linn | 3 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1839. | 4 | 28th | 5 | | Oct 3, 1843 – Oct 14, 1843 | Vacant | Vacant | Vacant |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1839. | 4 | 28th | 5 | Appointed to continue Linn's term.Elected to finish Linn's term. | Oct 14, 1843 – Mar 3, 1855 | Democratic | David Rice Atchison | 4 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1845.Lost re-election. | 5 | 29th | 5 | Appointed to continue Linn's term.Elected to finish Linn's term. | Oct 14, 1843 – Mar 3, 1855 | Democratic | David Rice Atchison | 4 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1845.Lost re-election. | 5 | 30th | 5 | Appointed to continue Linn's term.Elected to finish Linn's term. | Oct 14, 1843 – Mar 3, 1855 | Democratic | David Rice Atchison | 4 |
| 1 | Thomas Hart Benton | Democratic | Aug 10, 1821 – Mar 3, 1851 | Re-elected in 1845.Lost re-election. | 5 | 31st | 6 | Re-elected in 1849.Lost re-election. | Oct 14, 1843 – Mar 3, 1855 | Democratic | David Rice Atchison | 4 |
| 2 | Henry S. Geyer | Whig | Mar 4, 1851 – Mar 3, 1857 | Elected in 1851.Retired. | 6 | 32nd | 6 | Re-elected in 1849.Lost re-election. | Oct 14, 1843 – Mar 3, 1855 | Democratic | David Rice Atchison | 4 |
| 2 | Henry S. Geyer | Whig | Mar 4, 1851 – Mar 3, 1857 | Elected in 1851.Retired. | 6 | 33rd | 6 | Re-elected in 1849.Lost re-election. | Oct 14, 1843 – Mar 3, 1855 | Democratic | David Rice Atchison | 4 |
| 2 | Henry S. Geyer | Whig | Mar 4, 1851 – Mar 3, 1857 | Elected in 1851.Retired. | 6 | 34th | 7 | Failure to elect. | Mar 4, 1855 – Jan 12, 1857 | Vacant | Vacant | Vacant |
| 2 | Henry S. Geyer | Whig | Mar 4, 1851 – Mar 3, 1857 | Elected in 1851.Retired. | 6 | 34th | 7 | Elected late in 1857.Retired or lost re-election. | Jan 12, 1857 – Mar 3, 1861 | Democratic | James S. Green | 5 |
| 3 | Trusten Polk | Democratic | Mar 4, 1857 – Jan 10, 1862 | Elected in 1857.Expelled for supporting the Confederacy in the American Civil War. | 7 | 35th | 7 | Elected late in 1857.Retired or lost re-election. | Jan 12, 1857 – Mar 3, 1861 | Democratic | James S. Green | 5 |
| 3 | Trusten Polk | Democratic | Mar 4, 1857 – Jan 10, 1862 | Elected in 1857.Expelled for supporting the Confederacy in the American Civil War. | 7 | 36th | 7 | Elected late in 1857.Retired or lost re-election. | Jan 12, 1857 – Mar 3, 1861 | Democratic | James S. Green | 5 |
| 3 | Trusten Polk | Democratic | Mar 4, 1857 – Jan 10, 1862 | Elected in 1857.Expelled for supporting the Confederacy in the American Civil War. | 7 | 37th | 8 | | Mar 4, 1861 – Mar 17, 1861 | Vacant | Vacant | Vacant |
| 3 | Trusten Polk | Democratic | Mar 4, 1857 – Jan 10, 1862 | Elected in 1857.Expelled for supporting the Confederacy in the American Civil War. | 7 | 37th | 8 | Elected late in 1861.Expelled for supporting the Confederacy in the American Civil War. | Mar 17, 1861 – Jan 10, 1862 | Democratic | Waldo Johnson | 6 |
| Vacant | Vacant | Vacant | Jan 10, 1862 – Jan 17, 1862 | | 7 | 37th | 8 | | Jan 10, 1862 – Jan 17, 1862 | Vacant | Vacant | Vacant |
| 4 | John B. Henderson | Union | Jan 17, 1862 – Mar 3, 1869 | Appointed to finish Polk's term. | 7 | 37th | 8 | Appointed to continue Johnson's term.Successor qualified. | Jan 17, 1862 – Nov 13, 1863 | Union | Robert Wilson | 7 |
| 4 | John B. Henderson | Union | Jan 17, 1862 – Mar 3, 1869 | Elected to the next term in 1863.Retired. | 8 | 38th | 8 | Appointed to continue Johnson's term.Successor qualified. | Jan 17, 1862 – Nov 13, 1863 | Union | Robert Wilson | 7 |
| 4 | John B. Henderson | Union | Jan 17, 1862 – Mar 3, 1869 | Elected to the next term in 1863.Retired. | 8 | 38th | 8 | Elected to finish Johnson's term.Retired due to ill health. | Nov 13, 1863 – Mar 3, 1867 | Union Emancipation | B. Gratz Brown | 8 |
| 4 | John B. Henderson | Republican | Jan 17, 1862 – Mar 3, 1869 | Elected to the next term in 1863.Retired. | 8 | 39th | 8 | Elected to finish Johnson's term.Retired due to ill health. | Nov 13, 1863 – Mar 3, 1867 | Republican | B. Gratz Brown | 8 |
| 4 | John B. Henderson | Republican | Jan 17, 1862 – Mar 3, 1869 | Elected to the next term in 1863.Retired. | 8 | 40th | 9 | Elected in 1866 or 1867.Resigned to become Chief Justice of the U.S. Court of Claims. | Mar 4, 1867 – Dec 19, 1870 | Republican | Charles D. Drake | 9 |
| 5 | Carl Schurz | Republican | Mar 4, 1869 – Mar 3, 1875 | Elected in 1868.Retired. | 9 | 41st | 9 | Elected in 1866 or 1867.Resigned to become Chief Justice of the U.S. Court of Claims. | Mar 4, 1867 – Dec 19, 1870 | Republican | Charles D. Drake | 9 |
| 5 | Carl Schurz | Liberal Republican | Mar 4, 1869 – Mar 3, 1875 | Elected in 1868.Retired. | 9 | 41st | 9 | Appointed to continue Drake's term.Retired when successor elected. | Dec 19, 1870 – Jan 20, 1871 | Republican | Daniel T. Jewett | 10 |
| 5 | Carl Schurz | Liberal Republican | Mar 4, 1869 – Mar 3, 1875 | Elected in 1868.Retired. | 9 | 42nd | 9 | Elected to finish Drake's term.Lost re-election. | Jan 20, 1871 – Mar 3, 1873 | Democratic | Francis P. Blair | 11 |
| 5 | Carl Schurz | Republican | Mar 4, 1869 – Mar 3, 1875 | Elected in 1868.Retired. | 9 | 42nd | 9 | Elected to finish Drake's term.Lost re-election. | Jan 20, 1871 – Mar 3, 1873 | Democratic | Francis P. Blair | 11 |
| 5 | Carl Schurz | Republican | Mar 4, 1869 – Mar 3, 1875 | Elected in 1868.Retired. | 9 | 43rd | 10 | Elected in 1872 or 1873.Died. | Mar 4, 1873 – Sep 20, 1877 | Democratic | Lewis V. Bogy | 12 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Elected in 1874. | 10 | 44th | 10 | Elected in 1872 or 1873.Died. | Mar 4, 1873 – Sep 20, 1877 | Democratic | Lewis V. Bogy | 12 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Elected in 1874. | 10 | 45th | 10 | Elected in 1872 or 1873.Died. | Mar 4, 1873 – Sep 20, 1877 | Democratic | Lewis V. Bogy | 12 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Elected in 1874. | 10 | 45th | 10 | | Sep 20, 1877 – Sep 29, 1877 | Vacant | Vacant | Vacant |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Elected in 1874. | 10 | 45th | 10 | Appointed to continue Bogy's term.Retired. | Sep 29, 1877 – Jan 26, 1879 | Democratic | David H. Armstrong | 13 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Elected in 1874. | 10 | 45th | 10 | Elected to finish Bogy's term.Retired. | Jan 27, 1879 – Mar 3, 1879 | Democratic | James Shields | 14 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Elected in 1874. | 10 | 46th | 11 | Elected in 1879. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1881. | 11 | 47th | 11 | Elected in 1879. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1881. | 11 | 48th | 11 | Elected in 1879. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1881. | 11 | 49th | 12 | Re-elected in 1885. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1887. | 12 | 50th | 12 | Re-elected in 1885. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1887. | 12 | 51st | 12 | Re-elected in 1885. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1887. | 12 | 52nd | 13 | Re-elected in 1891. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1893. | 13 | 53rd | 13 | Re-elected in 1891. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1893. | 13 | 54th | 13 | Re-elected in 1891. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1893. | 13 | 55th | 14 | Re-elected in 1897.Retired. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1899. Lost re-election. | 14 | 56th | 14 | Re-elected in 1897.Retired. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1899. Lost re-election. | 14 | 57th | 14 | Re-elected in 1897.Retired. | Mar 4, 1879 – Mar 3, 1903 | Democratic | George G. Vest | 15 |
| 6 | Francis Cockrell | Democratic | Mar 4, 1875 – Mar 3, 1905 | Re-elected in 1899. Lost re-election. | 14 | 58th | 15 | Elected in 1903. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| Vacant | Vacant | Vacant | Mar 4, 1905 – Mar 18, 1905 | | 15 | 59th | 15 | Elected in 1903. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 7 | William Warner | Republican | Mar 18, 1905 – Mar 3, 1911 | Elected late in 1905.Retired. | 15 | 59th | 15 | Elected in 1903. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 7 | William Warner | Republican | Mar 18, 1905 – Mar 3, 1911 | Elected late in 1905.Retired. | 15 | 60th | 15 | Elected in 1903. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 7 | William Warner | Republican | Mar 18, 1905 – Mar 3, 1911 | Elected late in 1905.Retired. | 15 | 61st | 16 | Re-elected in 1909. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Elected in 1910. | 16 | 62nd | 16 | Re-elected in 1909. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Elected in 1910. | 16 | 63rd | 16 | Re-elected in 1909. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Elected in 1910. | 16 | 64th | 17 | Re-elected in 1914.Died. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1916. | 17 | 65th | 17 | Re-elected in 1914.Died. | Mar 4, 1903 – Apr 14, 1918 | Democratic | William J. Stone | 16 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1916. | 17 | 65th | 17 | | Apr 14, 1918 – Apr 30, 1918 | Vacant | Vacant | Vacant |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1916. | 17 | 65th | 17 | Appointed to continue Stone's term.Lost renomination to finish Stone's term. | Apr 30, 1918 – Nov 5, 1918 | Democratic | Xenophon P. Wilfley | 17 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1916. | 17 | 65th | 17 | Elected in 1918 to finish Stone's term. | Nov 6, 1918 – May 16, 1925 | Republican | Selden P. Spencer | 18 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1916. | 17 | 66th | 17 | Elected in 1918 to finish Stone's term. | Nov 6, 1918 – May 16, 1925 | Republican | Selden P. Spencer | 18 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1916. | 17 | 67th | 18 | Re-elected in 1920.Died. | Nov 6, 1918 – May 16, 1925 | Republican | Selden P. Spencer | 18 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1922.Retired. | 18 | 68th | 18 | Re-elected in 1920.Died. | Nov 6, 1918 – May 16, 1925 | Republican | Selden P. Spencer | 18 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1922.Retired. | 18 | 69th | 18 | Re-elected in 1920.Died. | Nov 6, 1918 – May 16, 1925 | Republican | Selden P. Spencer | 18 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1922.Retired. | 18 | 69th | 18 | | May 16, 1925 – May 25, 1925 | Vacant | Vacant | Vacant |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1922.Retired. | 18 | 69th | 18 | Appointed to continue Spencer's term.Lost elections to finish Spencer's term and to the next term. | May 25, 1925 – Dec 5, 1926 | Republican | George H. Williams | 19 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1922.Retired. | 18 | 69th | 18 | Elected to finish Spencer's term. | Dec 6, 1926 – Feb 3, 1933 | Democratic | Harry B. Hawes | 20 |
| 8 | James A. Reed | Democratic | Mar 4, 1911 – Mar 3, 1929 | Re-elected in 1922.Retired. | 18 | 70th | 19 | Also elected to the next term in 1926.Retired, then resigned early. | Dec 6, 1926 – Feb 3, 1933 | Democratic | Harry B. Hawes | 20 |
| 9 | Roscoe C. Patterson | Republican | Mar 4, 1929 – Jan 3, 1935 | Elected in 1928.Lost re-election. | 19 | 71st | 19 | Also elected to the next term in 1926.Retired, then resigned early. | Dec 6, 1926 – Feb 3, 1933 | Democratic | Harry B. Hawes | 20 |
| 9 | Roscoe C. Patterson | Republican | Mar 4, 1929 – Jan 3, 1935 | Elected in 1928.Lost re-election. | 19 | 72nd | 19 | Also elected to the next term in 1926.Retired, then resigned early. | Dec 6, 1926 – Feb 3, 1933 | Democratic | Harry B. Hawes | 20 |
| 9 | Roscoe C. Patterson | Republican | Mar 4, 1929 – Jan 3, 1935 | Elected in 1928.Lost re-election. | 19 | 72nd | 19 | Appointed to finish Hawes's term, having already been elected to the next term. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 9 | Roscoe C. Patterson | Republican | Mar 4, 1929 – Jan 3, 1935 | Elected in 1928.Lost re-election. | 19 | 73rd | 20 | Elected in 1932. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 10 | Harry S. Truman | Democratic | Jan 3, 1935 – Jan 17, 1945 | Elected in 1934. | 20 | 74th | 20 | Elected in 1932. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 10 | Harry S. Truman | Democratic | Jan 3, 1935 – Jan 17, 1945 | Elected in 1934. | 20 | 75th | 20 | Elected in 1932. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 10 | Harry S. Truman | Democratic | Jan 3, 1935 – Jan 17, 1945 | Elected in 1934. | 20 | 76th | 21 | Re-elected in 1938.Lost renomination. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 10 | Harry S. Truman | Democratic | Jan 3, 1935 – Jan 17, 1945 | Re-elected in 1940.Resigned to become U.S. Vice President. | 21 | 77th | 21 | Re-elected in 1938.Lost renomination. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 10 | Harry S. Truman | Democratic | Jan 3, 1935 – Jan 17, 1945 | Re-elected in 1940.Resigned to become U.S. Vice President. | 21 | 78th | 21 | Re-elected in 1938.Lost renomination. | Feb 3, 1933 – Jan 3, 1945 | Democratic | Joel B. Clark | 21 |
| 10 | Harry S. Truman | Democratic | Jan 3, 1935 – Jan 17, 1945 | Re-elected in 1940.Resigned to become U.S. Vice President. | 21 | 79th | 22 | Elected in 1944.Lost re-election. | Jan 3, 1945 – Jan 3, 1951 | Republican | Forrest C. Donnell | 22 |
| 11 | Frank P. Briggs | Democratic | Jan 18, 1945 – Jan 3, 1947 | Appointed to finish Truman's term.Lost election to full term. | 21 | 79th | 22 | Elected in 1944.Lost re-election. | Jan 3, 1945 – Jan 3, 1951 | Republican | Forrest C. Donnell | 22 |
| 12 | James P. Kem | Republican | Jan 3, 1947 – Jan 3, 1953 | Elected in 1946.Lost re-election. | 22 | 80th | 22 | Elected in 1944.Lost re-election. | Jan 3, 1945 – Jan 3, 1951 | Republican | Forrest C. Donnell | 22 |
| 12 | James P. Kem | Republican | Jan 3, 1947 – Jan 3, 1953 | Elected in 1946.Lost re-election. | 22 | 81st | 22 | Elected in 1944.Lost re-election. | Jan 3, 1945 – Jan 3, 1951 | Republican | Forrest C. Donnell | 22 |
| 12 | James P. Kem | Republican | Jan 3, 1947 – Jan 3, 1953 | Elected in 1946.Lost re-election. | 22 | 82nd | 23 | Elected in 1950. | Jan 3, 1951 – Sep 13, 1960 | Democratic | Thomas Hennings | 23 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1952. | 23 | 83rd | 23 | Elected in 1950. | Jan 3, 1951 – Sep 13, 1960 | Democratic | Thomas Hennings | 23 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1952. | 23 | 84th | 23 | Elected in 1950. | Jan 3, 1951 – Sep 13, 1960 | Democratic | Thomas Hennings | 23 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1952. | 23 | 85th | 24 | Re-elected in 1956.Died. | Jan 3, 1951 – Sep 13, 1960 | Democratic | Thomas Hennings | 23 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1958. | 24 | 86th | 24 | Re-elected in 1956.Died. | Jan 3, 1951 – Sep 13, 1960 | Democratic | Thomas Hennings | 23 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1958. | 24 | 86th | 24 | | Sep 13, 1960 – Sep 23, 1960 | Vacant | Vacant | Vacant |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1958. | 24 | 86th | 24 | Appointed to continue Henning's term.Elected to finish Henning's term. | Sep 23, 1960 – Dec 27, 1968 | Democratic | Edward V. Long | 24 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1958. | 24 | 87th | 24 | Appointed to continue Henning's term.Elected to finish Henning's term. | Sep 23, 1960 – Dec 27, 1968 | Democratic | Edward V. Long | 24 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1958. | 24 | 88th | 25 | Re-elected in 1962.Lost renomination, and resigned early. | Sep 23, 1960 – Dec 27, 1968 | Democratic | Edward V. Long | 24 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1964. | 25 | 89th | 25 | Re-elected in 1962.Lost renomination, and resigned early. | Sep 23, 1960 – Dec 27, 1968 | Democratic | Edward V. Long | 24 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1964. | 25 | 90th | 25 | Re-elected in 1962.Lost renomination, and resigned early. | Sep 23, 1960 – Dec 27, 1968 | Democratic | Edward V. Long | 24 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1964. | 25 | 90th | 25 | Appointed to finish Long's term, having been elected to next term. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1964. | 25 | 91st | 26 | Elected in 1968. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1970.Retired, then resigned early to give successor preferential seniority. | 26 | 92nd | 26 | Elected in 1968. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1970.Retired, then resigned early to give successor preferential seniority. | 26 | 93rd | 26 | Elected in 1968. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 13 | Stuart Symington | Democratic | Jan 3, 1953 – Dec 27, 1976 | Elected in 1970.Retired, then resigned early to give successor preferential seniority. | 26 | 94th | 27 | Re-elected in 1974. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Appointed to finish Symington's term, having already been elected to the next term. | 26 | 94th | 27 | Re-elected in 1974. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Elected in 1976. | 27 | 95th | 27 | Re-elected in 1974. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Elected in 1976. | 27 | 96th | 27 | Re-elected in 1974. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Elected in 1976. | 27 | 97th | 28 | Re-elected in 1980.Retired. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Re-elected in 1982. | 28 | 98th | 28 | Re-elected in 1980.Retired. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Re-elected in 1982. | 28 | 99th | 28 | Re-elected in 1980.Retired. | Dec 28, 1968 – Jan 3, 1987 | Democratic | Thomas Eagleton | 25 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Re-elected in 1982. | 28 | 100th | 29 | Elected in 1986. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Re-elected in 1988.Retired. | 29 | 101st | 29 | Elected in 1986. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Re-elected in 1988.Retired. | 29 | 102nd | 29 | Elected in 1986. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 14 | John Danforth | Republican | Dec 27, 1976 – Jan 3, 1995 | Re-elected in 1988.Retired. | 29 | 103rd | 30 | Re-elected in 1992. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 15 | John Ashcroft | Republican | Jan 3, 1995 – Jan 3, 2001 | Elected in 1994.Lost re-election. | 30 | 104th | 30 | Re-elected in 1992. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 15 | John Ashcroft | Republican | Jan 3, 1995 – Jan 3, 2001 | Elected in 1994.Lost re-election. | 30 | 105th | 30 | Re-elected in 1992. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 15 | John Ashcroft | Republican | Jan 3, 1995 – Jan 3, 2001 | Elected in 1994.Lost re-election. | 30 | 106th | 31 | Re-elected in 1998. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 16 | Jean Carnahan | Democratic | Jan 3, 2001 – Nov 23, 2002 | Appointed to begin the term of her husband, Mel Carnahan (D), who was posthumously elected in 2000.Lost election to finish her husband's term. | 31 | 107th | 31 | Re-elected in 1998. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 17 | Jim Talent | Republican | Nov 23, 2002 – Jan 3, 2007 | Elected in 2002 to finish Mel Carnahan's term.Lost re-election. | 31 | 107th | 31 | Re-elected in 1998. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 17 | Jim Talent | Republican | Nov 23, 2002 – Jan 3, 2007 | Elected in 2002 to finish Mel Carnahan's term.Lost re-election. | 31 | 108th | 31 | Re-elected in 1998. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 17 | Jim Talent | Republican | Nov 23, 2002 – Jan 3, 2007 | Elected in 2002 to finish Mel Carnahan's term.Lost re-election. | 31 | 109th | 32 | Re-elected in 2004.Retired. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 18 | Claire McCaskill | Democratic | Jan 3, 2007 – Jan 3, 2019 | Elected in 2006. | 32 | 110th | 32 | Re-elected in 2004.Retired. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 18 | Claire McCaskill | Democratic | Jan 3, 2007 – Jan 3, 2019 | Elected in 2006. | 32 | 111th | 32 | Re-elected in 2004.Retired. | Jan 3, 1987 – Jan 3, 2011 | Republican | Kit Bond | 26 |
| 18 | Claire McCaskill | Democratic | Jan 3, 2007 – Jan 3, 2019 | Elected in 2006. | 32 | 112th | 33 | Elected in 2010. | Jan 3, 2011 – Jan 3, 2023 | Republican | Roy Blunt | 27 |
| 18 | Claire McCaskill | Democratic | Jan 3, 2007 – Jan 3, 2019 | Re-elected in 2012.Lost re-election. | 33 | 113th | 33 | Elected in 2010. | Jan 3, 2011 – Jan 3, 2023 | Republican | Roy Blunt | 27 |
| 18 | Claire McCaskill | Democratic | Jan 3, 2007 – Jan 3, 2019 | Re-elected in 2012.Lost re-election. | 33 | 114th | 33 | Elected in 2010. | Jan 3, 2011 – Jan 3, 2023 | Republican | Roy Blunt | 27 |
| 18 | Claire McCaskill | Democratic | Jan 3, 2007 – Jan 3, 2019 | Re-elected in 2012.Lost re-election. | 33 | 115th | 34 | Re-elected in 2016.Retired. | Jan 3, 2011 – Jan 3, 2023 | Republican | Roy Blunt | 27 |
| 19 | Josh Hawley | Republican | Jan 3, 2019 – present | Elected in 2018. | 34 | 116th | 34 | Re-elected in 2016.Retired. | Jan 3, 2011 – Jan 3, 2023 | Republican | Roy Blunt | 27 |
| 19 | Josh Hawley | Republican | Jan 3, 2019 – present | Elected in 2018. | 34 | 117th | 34 | Re-elected in 2016.Retired. | Jan 3, 2011 – Jan 3, 2023 | Republican | Roy Blunt | 27 |
| 19 | Josh Hawley | Republican | Jan 3, 2019 – present | Elected in 2018. | 34 | 118th | 35 | Elected in 2022. | Jan 3, 2023 – present | Republican | Eric Schmitt | 28 |
| 19 | Josh Hawley | Republican | Jan 3, 2019 – present | Re-elected in 2024. | 35 | 119th | 35 | Elected in 2022. | Jan 3, 2023 – present | Republican | Eric Schmitt | 28 |
| 19 | Josh Hawley | Republican | Jan 3, 2019 – present | Re-elected in 2024. | 35 | 120th | 35 | Elected in 2022. | Jan 3, 2023 – present | Republican | Eric Schmitt | 28 |
| 19 | Josh Hawley | Republican | Jan 3, 2019 – present | Re-elected in 2024. | 35 | 121st | 36 | To be determined in the 2028 election. | To be determined in the 2028 election. | To be determined in the 2028 election. | To be determined in the 2028 election. | To be determined in the 2028 election. |
| # | Senator | Party | Years in office | Electoral history | T | C | T | Electoral history | Years in office | Party | Senator | # |
| Class 1 | Class 1 | Class 1 | Class 1 | Class 1 | Class 1 | C | Class 3 | Class 3 | Class 3 | Class 3 | Class 3 | Class 3 |