# List of number-one dance airplay hits of 2006 (U.S.)

These are the Billboard magazine Hot Dance Airplay number one hits of 2006.
Note that Billboard publishes charts with an issue date approximately 7–10 days in advance.
| † | Number-one rhythmic song of the year |
| Issue date | Song | Artist(s) | Remixer(s) |
| January 7 | "Don't Forget About Us" | Mariah Carey | Ralphi Rosario; Craig J.; Quentin Harris; Tony Moran |
| January 14 | "Don't Forget About Us" | Mariah Carey | Ralphi Rosario; Craig J.; Quentin Harris; Tony Moran |
| January 21 | "Don't Forget About Us" | Mariah Carey | Ralphi Rosario; Craig J.; Quentin Harris; Tony Moran |
| January 28 | "Everytime We Touch" | Cascada | |
| February 4 | "Everytime We Touch" | Cascada | |
| February 11 | "Everytime We Touch" | Cascada | |
| February 18 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| February 25 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| March 4 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| March 11 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| March 18 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| March 25 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| April 1 | "Sorry" | Madonna | Pet Shop Boys; Paul Oakenfold |
| April 8 | "Be Without You" | Mary J. Blige | Moto Blanco |
| April 15 | "Be Without You" | Mary J. Blige | Moto Blanco |
| April 22 | "Be Without You" | Mary J. Blige | Moto Blanco |
| April 29 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| May 6 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| May 13 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| May 20 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| May 27 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| June 3 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| June 10 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| June 17 | "SOS" | Rihanna | Jason Nevins, Chris Cox |
| June 24 | "Get Together" | Madonna | Jacques Lu Cont; Tiefschwarz |
| July 1 | "What's Left of Me" | Nick Lachey | Passengerz |
| July 8 | "What's Left of Me" | Nick Lachey | Passengerz |
| July 15 | "Get Together" | Madonna | |
| July 22 | "Get Together" | Madonna | |
| July 29 | "Get Together" | Madonna | |
| August 5 | "Unfaithful" | Rihanna | Tony Moran |
| August 12 | "Unfaithful" | Rihanna | Tony Moran |
| August 19 | "Unfaithful" | Rihanna | Tony Moran |
| August 26 | "Ain't No Other Man" | Christina Aguilera | Ospina & Sullivan; Junior Vasquez; Shapeshifters |
| September 2 | "Ain't No Other Man" | Christina Aguilera | Ospina & Sullivan; Junior Vasquez; Shapeshifters |
| September 9 | "Ain't No Other Man" | Christina Aguilera | Ospina & Sullivan; Junior Vasquez; Shapeshifters |
| September 16 | "Ain't No Other Man" | Christina Aguilera | Ospina & Sullivan; Junior Vasquez; Shapeshifters |
| September 23 | "Ain't No Other Man" | Christina Aguilera | Ospina & Sullivan; Junior Vasquez; Shapeshifters |
| September 30 | "SexyBack" | Justin Timberlake | Armand Van Helden, Richard Vission |
| October 7 | "SexyBack" | Justin Timberlake | Armand Van Helden, Richard Vission |
| October 14 | "SexyBack" | Justin Timberlake | Armand Van Helden, Richard Vission |
| October 21 | "What a Feeling" | Peter Luts & Dominico | |
| October 28 | "What a Feeling" | Peter Luts & Dominico | |
| November 4 | "What a Feeling" | Peter Luts & Dominico | |
| November 11 | "Jump" | Madonna | Axwell; Jacques Lu Cont; Junior Sanchez |
| November 18 | "Jump" | Madonna | Axwell; Jacques Lu Cont; Junior Sanchez |
| November 25 | "Jump" | Madonna | Axwell; Jacques Lu Cont; Junior Sanchez |
| December 2 | "Jump" | Madonna | Axwell; Jacques Lu Cont; Junior Sanchez |
| December 9 | "Jump" | Madonna | Axwell; Jacques Lu Cont; Junior Sanchez |
| December 16 | "My Love" | Justin Timberlake featuring T.I. | Paul Oakenfold; Linus Loves, Hani |
| December 23 | "My Love" | Justin Timberlake featuring T.I. | Paul Oakenfold; Linus Loves, Hani |
| December 30 | "My Love" | Justin Timberlake featuring T.I. | Paul Oakenfold; Linus Loves, Hani |