# U.S. Route 64 in Oklahoma

U.S. Route 64 (US-64) is a U.S. highway running from the Four Corners area to the Outer Banks of North Carolina. Between these two points, the highway passes through the entire width of Oklahoma; a total of 591.17 miles (951.40 km) of US-64 lies in the state of Oklahoma. US-64 enters the state from New Mexico, crossing the line between the two states between Clayton, New Mexico, and Boise City in Cimarron County. The route runs the full length of the Oklahoma Panhandle, then serves the northernmost tier of counties in the main body of the state before dipping southeastward to Tulsa, the state's second-largest city. From Tulsa, the highway continues southeast, leaving Oklahoma just west of Fort Smith, Arkansas. In addition to Tulsa, US-64 serves fifteen Oklahoma counties and the cities of Guymon, Woodward, Enid, and Muskogee.
US-64 has been a part of the United States Numbered Highways system from the program's inception in 1926. US-64's route has remained roughly the same since then, although it has undergone alterations several times, mainly changing its course through towns and moving the highway designation to higher-capacity expressways and freeways.

## Route description
### The Panhandle

U.S. Route 64 crosses the New Mexico–Oklahoma state line northeast of Clayton, New Mexico, concurrent with US-56 and US-412. The three highways enter the state just north of the extreme southwest corner of Cimarron County, the westernmost tip of the Oklahoma Panhandle. The highways head northeast, passing through disconnected parcels of the Rita Blanca National Grassland. The first town US-56, US-64, and US-412 encounter in Oklahoma is unincorporated Felt, of which they skirt the northern edge. The highways then cross the Beaver River before intersecting US-385, which joins the other three highways in a concurrency as they approach Boise City, the county seat. In Boise City, the highways reach a traffic circle which surrounds the Cimarron County Courthouse. At this traffic circle, US-56, US-64, and US-412 all turn east, while US-385 splits away to the north. State Highway 3 (SH-3) enters the circle from the north and leaves from the east, following US-64, while SH-325 begins at the circle and heads west toward Kenton. East of town, US-56/US-64/US-412/SH-3 have an interchange with US-287, which bypasses Boise City to the east. Six miles (9.7 km) northeast of here, US-56 splits away from the other highways; it continues northeast, while US-64/US-412/SH-3 turn onto a due east course. The routes intersect SH-171 eight miles (13 km) east of the split.
Approximately twelve miles (19 km) east of the SH-171 junction, US-64/US-412/SH-3 cross into Texas County. Seven miles (11 km) east of the county line, at unincorporated Four Corners, SH-95 joins the concurrency; it splits away after following the other three routes for five miles (8.0 km). The next major highway junction lies eighteen miles (29 km) to the east, where SH-136 joins with US-64/US-412/SH-3 as the highways turn south toward Guymon. The four highways cross the Beaver River once again before entering that city, Texas County's seat and the largest city in the Panhandle, on Main Street. In Guymon, US-64 splits away to the east along NE 12th Street, while US-412 and state highways 3 and 136 continue south. US-64 is accompanied on 12th Street by truck routes for the latter three highways. At the intersection with US-54, the truck routes turn southwest, while US-64 turns northeast, following US-54 out of town US-54/US-64 continue northeast through eastern Texas County, running parallel to a Union Pacific rail line. After crossing the Beaver River (the only crossing for US-54, but the third for US-64), the highways cut through the northwest corner of the town of Optima. Continuing northeast, US-54 and US-64 run just southeast of Panoma before coming to Hooker. There, US-54/US-64 serve as the northern terminus of SH-94. After the SH-94 junction, US-54 continues northeast toward Tyrone and Liberal, Kansas, while US-64 splits off onto a due east course. The road passes south of Baker before leaving Texas County.
Next, US-64 passes through Beaver County, the easternmost of the three counties forming the Oklahoma Panhandle. About four miles (6.4 km) east of the county line, US-64 reaches the town of Turpin; here, the highway begins a concurrency with US-83. Approximately three miles (4.8 km) north of Turpin, the two highways come to a junction with US-270. US-83 and westbound US-270 continue north from this junction toward Liberal, while US-64 and US-270 eastbound form a concurrency heading due east. Passing north of Floris, the highways proceed east for about 18+1⁄2 miles (29.8 km) without any curves or junctions with other highways before reaching Forgan. East of Forgan lies a highway junction with SH-23—here, US-270 splits away from US-64, turning south along SH-23 en route to the county seat, Beaver. SH-23 joins US-64 to form a one-mile (1.6 km) concurrency before also splitting away toward its northern terminus at the Kansas line. US-64 does not intersect any other highways in the 29-mile (47 km) segment of highway in Beaver County east of the SH-23 junction. As it zig-zags southeastward, the highway passes through the towns of Knowles and Gate. Three miles (4.8 km) east of Gate, the highway crosses the Beaver–Harper county line, the eastern boundary of the Oklahoma Pandhandle, and enters the main body of the state.

### Northern Oklahoma

Just two miles (3.2 km) east of its entry into Harper County, US-412 begins a concurrency with US-283. The two highways pass through Rosston, then US-283 splits away to the south toward Laverne. US-64 continues alone on a due east course for eight miles (13 km) before reaching the northern terminus of SH-46. The highway continues east, then veers northeast, and turns back to the east before meeting up with US-183 on the south side of Buffalo, the county seat. US-64 turns north at this intersection, overlapping US-183 through town. The two routes part ways northeast of town, with US-183 continuing on a northerly course toward Kansas and US-64 turning east once again. On the east end of the county, US-64 begins another concurrency, this time with SH-34. About 2+1⁄2 miles (4.0 km) east of the junction, the two highways cross the Cimarron River, which forms the northeastern boundary of Harper County.
As US-64 and SH-34 cross the Cimarron River, the two highways enter Woods County. SH-34 splits off to the north shortly thereafter. US-64 continues on east, passing through unincorporated Plainview and turning southeast to intersect SH-50 at its northern terminus at Camp Houston, north of Freedom. The next highway junction is just over thirteen miles (21 km) east of Camp Houston, and is the northern terminus of SH-14 as signed; however, ODOT documents show SH-14 continuing east along US-64 from this point for slightly less than thirteen miles (21 km). The two highways proceed into the Woods County seat, Alva, where they join US-281. This concurrency lasts about one mile (1.6 km) before US-281 splits off to the north on the east side of town; at this point, SH-14 ends. US-64 continues east by itself for six miles (9.7 km) before reaching the eastern limit of Woods County.
The next county that US-64 serves on its path across Oklahoma is Alfalfa County. After passing eight miles (13 km) through rural Alfalfa county, it approaches the unincorporated Ingersoll, whereupon it continues another two miles (3.2 km) until the route intersects state highways 8, 11, and 58. All three of these highways extend north from the intersection, while SH-11 continues east. US-64 turns south at this intersection, overlapping SH-8 and SH-58. They then pass through Cherokee, seat of Alfalfa County. About five miles (8.0 km) south of town, SH-8 splits away to the southwest, while US-64 and SH-58 turn due east. Approximately six miles (9.7 km) east of that intersection, SH-58 also splits away, headed south toward Helena. US-64 proceeds east to Jet, where it forms the southern terminus of SH-38. Four miles west of Jet, the highway exits Alfalfa County.
Upon leaving Alfalfa County, US-64 passes into Grant County. The first town the highway passes through in Grant County is Nash, where it begins a concurrency with SH-132. This concurrency lasts for two miles (3.2 km) before SH-132 splits away. Eight miles (13 km) east of this junction, US-64 intersects US-60 and US-81 in a T junction. US-81 northbound and US-60 eastbound continue straight, while US-64 eastbound turns south along with southbound US-81 and westbound US-60 (creating a wrong-way concurrency with US-60). The three highways continue south into Garfield County. Fourteen miles (23 km) south of the T junction, US-60 / US-64 / US-81 serve as the eastern terminus of SH-45. This junction marks the highways' entry into the Enid area. The highways serve as the city limit boundary between Enid (to the west) and North Enid (to the east). About 1+1⁄2 miles (2.4 km) south of the SH-45 junction, US-64 splits away from the other two highways at an interchange where US-64 continues south and US-60 / US-81 take a southwesterly tack. US-64 heads south from the interchange on North 4th Street. At Willow Road, US-64 turns due east; it follows Willow Road for about two miles (3.2 km) before turning south on North 30th Street. This street has a parclo interchange with Owen K. Garriott Road, which carries US-412; here, US-64 joins US-412, and the two highways head due east out of Enid as a four-lane expressway. East of Enid, the two routes pass between Breckenridge and Fairmont. South of Garber lies an interchange between US-64 / US-412 and SH-74. SH-15 also begins here, extending north along SH-74. US-64 / US-412 continue east out of Garfield County.
US-64 and US-412 next enter Noble County. The two highways' first junction with another highway in the county is a cloverleaf interchange at I-35 (exit 194 on the interstate). US-412 continues straight through the interchange, forming the Cimarron Turnpike, while US-64 follows I-35 southbound. US-64 splits away from the interstate in Perry at exit 186, heading due east, deeper into Perry. In downtown Perry, about 2+1⁄3 miles (3.8 km) east of I-35, US-64 has a brief concurrency with US-77. US-64 continues east out of Perry. West of Morrison, the highway crosses US-177. US-64 then passes through Morrison. East of town, US-64 has an interchange with the Cimarron Turnpike, still carrying US-412, at turnpike exit 22. US-64 continues northeast to Lela, where it serves as the northern terminus of SH-108, which runs along the Noble–Pawnee county line. US-64 continues east into Pawnee County.
About seven miles (11 km) into Pawnee County, US-64 enters the county seat, Pawnee. Here, the route begins a concurrency with SH-18. The two highways head southeast out of town together for just over two miles (3.2 km) before SH-18 splits off to the south toward Lone Chimney. US-64 continues alone to the east for about 12+3⁄4 miles (20.5 km) before beginning another concurrency, this time with SH-99, on the outskirts of Cleveland. The two highways leave Cleveland, proceeding east through unincorporated territory, before re-entering the city. Here, the two highways head in separate directions, with SH-99 heading north and US-64 heading southeast. This portion of the highway runs parallel to Keystone Lake, a reservoir formed by the impounded Arkansas River. US-64 intersects with SH-48 at the latter's northern terminus before merging with US-412 in a partial interchange (the missing movements are provided via SH-48). This interchange is also the Cimarron Turnpike's eastern endpoint.

### Tulsa area

US-64 / US-412 continue east from the eastern terminus of the Cimarron Turnpike in southeastern Pawnee as a freeway known as the Keystone Expressway. This highway continues eastward along a peninsula into Lake Keystone. Here, the highway serves as the southern limit of Westport and Mule Barn, which remains an incorporated town despite having a population of zero. The freeway turns southeast, briefly entering Westport before crossing Lake Keystone into Osage County. US-64 and US-412 run through Osage County for just under 1+1⁄2 miles (2.4 km), cutting across a corner of the county before entering Tulsa County.
Upon entering Tulsa County, US-64 / US-412 serve as the northern terminus of SH-151. The freeway passes through an outlying parcel of Sand Springs, running parallel to the Arkansas River, before emerging into unincorporated territory. Proceeding east, the freeways re-enter Sand Springs, passing through an interchange with SH-97 just south of downtown. SH-51 joins the Keystone Expressway at this interchange. The freeway then enters Tulsa (estimated population 394,098 as of 2012), the second-largest city in Oklahoma. The Keystone Expressway continues to an interchange at the northwest corner of the Inner Dispersal Loop (IDL), a ring of freeways encircling downtown Tulsa. At this interchange, US-64 meets I-244 and the L.L. Tisdale Parkway. US-412 follows I-244 east, while US-64 and SH-51 turn south along I-244 westbound. The three highways then run along the western side of the IDL. At the southwest corner of the loop lies an interchange serving as the western terminus of unsigned I-444. US-64 and SH-51 split away from I-244 at this interchange to join I-444 and US-75. I-444, US-64, US-75, and SH-51 head east along the south leg of the IDL. At the southeast corner of the IDL, the highways part ways; I-444 and US-75 turn north along the east side of the IDL, while US-64 and SH-51 split off to the east.
US-64 and SH-51 proceed southeast from downtown along another freeway, the Broken Arrow Expressway. Between Lewis Avenue and Sheridan Road, a rail line runs down the median of the highway. After the freeway splits away from the railroad alignment, it comes to an interchange with I-44 / SH-66. From here, the Broken Arrow Expressway heads southeast to an interchange with the Mingo Valley Expressway, which carries US-169. Here, US-64 splits away to follow the southbound Mingo Valley Expressway, while SH-51 continues southeast on the Broken Arrow Expressway. US-64 / US-169 follow a due south course to an interchange with the Creek Turnpike. The freeway merges with a free section of the turnpike, heading west. At an interchange with Memorial Drive, US-64 turns south, splitting away from the freeway. US-169 ends at this point, and tolls resume on the Creek Turnpike to the west of the interchange.
From here, US-64 proceeds south on Memorial Drive into Bixby. In Bixby, the highway crosses the Arkansas River for the second time. Further south, it serves as the eastern terminus of SH-67. On the southern outskirts of Bixby, it turns east, passing through unincorporated Leonard before exiting Tulsa County.

### Eastern Oklahoma

Southeast of Leonard, US-64 cuts across extreme southwestern Wagoner County, passing through Stone Bluff, before entering Muskogee County. Approximately 2+1⁄2 miles (4.0 km) south of the county line, the highway serves the town of Haskell, where it begins a concurrency with SH-72 and junctions with SH-104 at its western terminus. US-64 and SH-72 head south from Haskell, passing through unincorporated Jamesville and coming to a junction south of the settlement. Here, SH-72 splits away from US-64, continuing a southbound course straight through the junction to join westbound US-62. The western leg of this junction leads to westbound SH-16. US-64 turns to the east, joined by eastbound US-62 and SH-16. The three routes serve as the southern terminus of SH-162, a spur route to Taft. The road forms a gentle S-curve as it comes into the city of Muskogee, the county seat. Here, the routes split ways at an intersection with US-69; US-62 ad SH-16 turn north along US-69, while US-64 follows southbound US-69. US-62 BUS / US-64 BUS continue east from the intersection. US-64 / US-69 continue south to an intersection with Peak Boulevard, where US-64 heads east on its own. US-62 follows Peak Boulevard for about 1+1⁄4 miles (2.0 km), exiting at an interchange with US-64 Business; mainline US-64 continues south past the terminus of US-64 Business, while SH-165 continues east on Peak Boulevard. US-64 proceeds south for just under sixteen miles (26 km) to Warner, where it forms the eastern terminus of US-266 and the northern terminus of SH-2. US-64 turns back to the east here, running parallel to I-40 between Warner and Webbers Falls, where it has an interchange with the Muskogee Turnpike. East of the turnpike interchange, US-64 begins a concurrency with SH-100. The two highways pass northwest of downtown Webbers Falls before crossing the Arkansas River, which forms the boundary of Muskogee County, a third time.
The final county US-64 passes through on its trek through Oklahoma is Sequoyah County, where much of its path loosely follows that of I-40. SH-100 splits away from US-64 at an intersection about 3⁄4 mile (1.2 km) east of the Muskogee–Sequoyah county line, in Gore. At this same intersection, US-64 is joined by SH-10, which follows it out of Gore before splitting off southeast of town. US-64 continues alone to the town of Vian, where it intersects SH-82. East of Vian, US-64 serves the county seat, Sallisaw, where it overlaps US-59. On the southeast side of the city, it comes to an interchange with I-40 (exit 311 from the Interstate). US-64 heast southeast from Sallisaw, turning back to the east at the eastern terminus of SH-141. It crosses under I-40 just east of here, although there are no ramps between the two roads. US-64 then enters Muldrow. Here, the highway intersects SH-64B. US-64 then continues into Roland, where another interchange with I-40 (exit 325) is located. The highway then turns southeast, passing north of Moffett, with two interchanges serving SH-64D, which heads north to Dora, Arkansas, and Grand Boulevard, which heads south into Moffett. US-64 then crosses the Arkansas River a fourth time, the final crossing in Oklahoma; the river's east bank is the Oklahoma–Arkansas state line.

## History

US-64 was one of the original United States Numbered Highways designated at the highway system's creation on November 11, 1926. It stretched from the New Mexico state line in the Oklahoma panhandle east to the Arkansas state line near Fort Smith. The original route included two sharp, right-angle turns near the city of Freedom. On February 19, 1934, the Oklahoma Highway Commission approved the re-routing of US-64 onto a roadway a bit further west to eliminate these turns. On November 9, 1937, the highway was re-routed through the city of Tulsa, as well. Later, in 1943 just south of the city of Muskogee, US-64 and SH-2, which was then concurrent with US-64, were relocated slightly to the west to allow for the new Davis Field air base to be constructed at the place the highways had run before relocation.
On July 7, 1947, another modification to the route was made, moving its western terminus from the northern portion of the panhandle to a new roadway in the southern section. The next significant change to the highway took place on April 4, 1960, when it was realigned to the north between the cities of Gore and Vian. Two years later, on April 4, 1962, US-64 was relocated to the north west of Tulsa, near Sand Springs. On November 4, 1963, a bypass was added through the city of Enid. It was designated as US-64 Bypass and ran on Willow Avenue and 30th Street. A couple of months later, on February 3, 1964, US-64 was moved onto a freeway through the southeastern portion of Tulsa. Later, on December 1 of the same year, similar reroutings through Tulsa and Broken Arrow were approved by the Oklahoma Department of Highways.
The routing of US-64 was modified further on July 6, 1965, through the city of Enid. The routing of US-64 Bypass, which was designated two years earlier, was replaced by that of US-64 itself, and what used to be US-64 became part of a new business loop (US-64 Bus.) through the city. The Oklahoma Department of Highways approved a rerouting of the designation onto a freeway south of Muskogee on October 3, 1966, and a relocation slightly to the north between Jamesville and Muskogee on July 10, 1967. However, neither of these modifications was completed until around 1969. Then, on June 1, 1970, US-64 was relocated across the Arkansas River between Webber Falls and Gore. Between then and 1972, US-64 was realigned between Enid and Perry, with the old highway becoming SH-164.
By 1974, the majority of the freeway that US-64 was to occupy in Tulsa was complete, and it was relocated onto the completed portion of the freeway. Only the portion in the downtown section of the city was yet to be completed. The remainder of the freeway, the concurrency with Interstate 444, was not completed until about 1983. The next and final major modification to the designation of US-64 took place when it was moved from its route through eastern Tulsa onto the newly constructed Creek Turnpike over the first half of 1992. The route has undergone only minor changes since then.
The section of US-64 between Webbers Falls and Gore was pressed into service as a detour for I-40 traffic after the collapse of its bridge over the Arkansas River on May 26, 2002. The detour significantly impacted the town of Gore. Local firefighters directed traffic there 24 hours a day, with daytime temperatures approaching 100 °F (38 °C). Businesses in Gore reported loss of revenue due to the traffic; one gas station reported a 30% decline in revenue while traffic was detoured through town. Delays of thirty to fifty minutes on the 12-mile (19 km) detour were typical, although trains passing through Gore could lengthen wait times by 15 minutes.

## Major intersections

| County | Location | mi | km | Exit | Destinations | Notes |
| Cimarron | ​ | 0.00 | 0.00 | | US 56 west / US 64 west / US 412 west – Clayton | Continuation into New Mexico |
| Cimarron | ​ | 28.4 | 45.7 | | US 385 south – Dalhart | Western end of US-385 concurrency |
| Cimarron | Boise City | 31.7 | 51.0 | | US 385 north / SH-3 west (Cimarron Avenue north) / SH-325 west (Main Street west) – Kenton, Denver Co. | Traffic circle around Cimarron County courthouse; eastern end of US-385 concurrency; western end of SH-3 concurrency; eastern terminus of SH-325 |
| Cimarron | ​ | 33.3 | 53.6 | | US 287 – Amarillo, Denver CO, Stratford TX | Interchange |
| Cimarron | ​ | 39.4 | 63.4 | | US 56 east | Eastern end of US-56 concurrency; former SH-114 |
| Cimarron | ​ | 47.1 | 75.8 | | SH-171 | |
| Texas | ​ | 66.0 | 106.2 | | SH-95 north | Western end of SH-95 concurrency |
| Texas | ​ | 71.0 | 114.3 | | SH-95 south | Eastern end of SH-95 concurrency |
| Texas | ​ | 89.1 | 143.4 | | SH-136 north | Western end of SH-136 concurrency |
| Texas | Guymon | 93.4 | 150.3 | | US 412 / SH-3 east (Main Street south) / US 412 Truck / SH-3 Truck / SH-136 Truck begin | Eastern end of US-412 concurrency; western end of Truck Routes concurrency |
| Texas | Guymon | 94.2 | 151.6 | | US 54 west / US 412 Truck / SH-3 Truck / SH-136 Truck – Goodwell | Eastern end of truck routes concurrency; western end of US-54 concurrency |
| Texas | Hooker | 112.6 | 181.2 | | SH-94 | Northern terminus of SH-94 |
| Texas | Hooker | 113.1 | 182.0 | | US 54 east – Liberal KS | Eastern end of US-54 concurrency |
| Beaver | Turpin | 131.3 | 211.3 | | US 83 south | Western end of US-83 concurrency |
| Beaver | ​ | 134.3 | 216.1 | | US 83 north / US 270 west | Eastern end of US-83 concurrency; western end of US-270 concurrency |
| Beaver | ​ | 154.2 | 248.2 | | US 270 east / SH-23 south | Eastern end of US-270 concurrency, western end of SH-23 concurrency |
| Beaver | ​ | 155.2 | 249.8 | | SH-23 north | Eastern end of SH-23 concurrency |
| Harper | ​ | 186.4 | 300.0 | | US 283 north | Western end of US-283 concurrency |
| Harper | ​ | 190.8 | 307.1 | | US 283 south | Eastern end of US-283 concurrency |
| Harper | ​ | 198.8 | 319.9 | | SH-46 | |
| Harper | Buffalo | 205.6 | 330.9 | | US 183 south | Western end of US-183 concurrency |
| Harper | ​ | 207.5 | 333.9 | | US 183 north | Eastern end of US-183 concurrency |
| Harper | ​ | 221.6 | 356.6 | | SH-34 south | Western end of SH-34 concurrency |
| Woods | ​ | 225.1 | 362.3 | | SH-34 north | Eastern end of SH-34 concurrency |
| Woods | ​ | 236.9 | 381.3 | | SH-50 | Northern terminus of SH-50 |
| Woods | ​ | 250.2 | 402.7 | | SH-14 south | Northern terminus of SH-14 |
| Woods | Alva | 262.1 | 421.8 | | US 281 south (College Boulevard) | Western end of US-281 concurrency |
| Woods | Alva | 263.1 | 423.4 | | US 281 north (Lane Boulevard) | Eastern end of US-281 concurrency |
| Alfalfa | ​ | 279.0 | 449.0 | | SH-8 / SH-58 north / SH-11 – Burlington, Medford | Western end of SH-8/SH-58 concurrency |
| Alfalfa | ​ | 288.2 | 463.8 | | SH-8 south | Eastern end of SH-8 concurrency |
| Alfalfa | ​ | 294.1 | 473.3 | | SH-58 south | Eastern end of SH concurrency |
| Alfalfa | Jet | 298.1 | 479.7 | | SH-38 | Southern terminus of SH-38 |
| Grant | Nash | 306.0 | 492.5 | | SH-132 north | Western end of SH-132 concurrency |
| Grant | ​ | 308.0 | 495.7 | | SH-132 south | Eastern end of SH-132 concurrency |
| Grant | ​ | 316.0 | 508.6 | | US 60 east / US 81 north | Northern end of US-60/US-81 concurrency |
| Garfield | Enid | 330.0 | 531.1 | | SH-45 | Eastern terminus of SH-45 |
| Garfield | Enid | 331.2 | 533.0 | | US 60 west / US 81 south (Van Buren Bypass) / US 64 east (4th Street) | Interchange; westbound access to US-60 west/US-81 south via U-turn north of exit; Southern end of US-60/US-81 concurrency |
| Garfield | Enid | 336.9 | 542.2 | | US 412 / US 64 Bus. west (Owen K. Garriot Road) | Interchange; western end of US-412 concurrency |
| Garfield | ​ | 351.2 | 565.2 | | SH-15 east / SH-74 | Interchange; western terminus of SH-15 |
| Noble | ​ | 365.3 | 587.9 | | I-35 north / US 412 east / Cimarron Turnpike east – Wichita, Tulsa | Cloverleaf interchange; eastern end of US-412 concurrency; northern end of I-35 concurrency; I-35 exit 194B |
| Noble | ​ | 366.1 | 589.2 | 193 | Airport Road | Northbound exit and southbound entrance; exit number follows I-35 |
| Noble | Perry | 373.0 | 600.3 | | I-35 south / Fir Street west – Guthrie | Southern end of I-35 concurrency; I-35 exit 186 |
| Noble | Perry | 375.4 | 604.1 | | US 77 south (7th Street) | Western end of US-77 concurrency |
| Noble | Perry | 375.5 | 604.3 | | US 77 north (6th Street) | Eastern end of US-77 concurrency |
| Noble | ​ | 387.6 | 623.8 | | US 177 | |
| Noble | ​ | 392.2 | 631.2 | | US 412 / Cimarron Turnpike – Tulsa, Enid | US 412/Cimarron Tpk. exit 22 |
| Noble–Pawnee county line | Lela | 396.0 | 637.3 | | SH-108 | Northern terminus of SH-108 |
| Pawnee | Pawnee | 403.4 | 649.2 | | SH-18 north (4th Street north) | Western end of SH-18 concurrency |
| Pawnee | ​ | 405.6 | 652.7 | | SH-18 south – Cushing | Eastern end of SH-18 concurrency |
| Pawnee | ​ | 418.0 | 672.7 | | SH-99 south | Western end of SH-99 concurrency |
| Pawnee | Cleveland | 424.3 | 682.8 | | SH-99 north (Broadway Street north) | Eastern end of SH-99 concurrency |
| Pawnee | ​ | 431.8 | 694.9 | | SH-48 south to US 412 west / Cimarron Turnpike west – Mannford, Bristow, Enid | Northern terminus of SH-48 |
| Pawnee | ​ | 432.5 | 696.0 | — | US 412 west / Cimarron Turnpike west – Stillwater, Enid | Westbound left exit and eastbound left entrance; west end of freeway section; western end of US-412 concurrency |
| Pawnee | ​ | 434.2 | 698.8 | — | Westport Road | Serves Westport Airport |
| Pawnee | ​ | 437.7 | 704.4 | — | Old Keystone Road | |
| Pawnee | ​ | 439.6 | 707.5 | — | Bears Glen | |
| Osage | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions |
| Tulsa | ​ | 442.0 | 711.3 | — | SH-151 west – Keystone State Park | Northern terminus of SH-151 |
| Tulsa | Sand Springs | 443.3 | 713.4 | — | 209th West Avenue | |
| Tulsa | Sand Springs | 445.3 | 716.6 | — | 177th West Avenue | |
| Tulsa | Sand Springs | 448.6 | 722.0 | — | Willow Street | |
| Tulsa | Sand Springs | 449.8 | 723.9 | — | SH-51 west / SH-97 junction – Sapulpa, Mannford | Western end of SH-51 concurrency |
| Tulsa | Sand Springs | | | | 2nd Street | Eastbound entrance only |
| Tulsa | Sand Springs | 450.6 | 725.2 | — | Adams Road | Westbound exit only |
| Tulsa | Sand Springs | 451.7 | 726.9 | — | 81st West Avenue | |
| Tulsa | ​ | 452.9 | 728.9 | — | 65th West Avenue | |
| Tulsa | Tulsa | 454.0 | 730.6 | — | 49th West Avenue | |
| Tulsa | Tulsa | 455.1 | 732.4 | — | 33rd West Avenue | Westbound exit and eastbound entrance |
| Tulsa | Tulsa | 455.5 | 733.1 | — | 25th West Avenue | |
| Tulsa | Tulsa | 455.9 | 733.7 | — | Quanah Avenue | Eastbound exit and westbound entrance |
| Tulsa | Tulsa | 456.5 | 734.7 | — | I-244 east / US 412 east / L.L. Tisdale Parkway north to US 75 north – Bartlesville, Joplin | Eastern end of US-412 concurrency; northern end of I-244 concurrency; I-244 exit 5B |
| Tulsa | Tulsa | 456.8 | 735.1 | 5A | 2nd Street – Downtown | Eastbound exit and westbound entrance |
| Tulsa | Tulsa | 457.2 | 735.8 | — | I-244 west / US 75 south (Red Fork Expressway south) / I-444 begin – Okmulgee, Oklahoma City | Southern end of I-244 concurrency; western end of US-75/unsigned I-444 concurrency; I-244 exit 4B |
| see I-444 |||||||
| Tulsa | Tulsa | 458.8 | 738.4 | — | US 75 / I-444 north – Bartlesville | Eastern end of US-75/unsigned I-444 concurrency; eastbound left exit and westbound entrance |
| Tulsa | Tulsa | 458.8 | 738.4 | — | Detroit Avenue – Downtown, T.C.C.-Metro | Westbound exit and eastbound entrance |
| Tulsa | Tulsa | 458.8 | 738.4 | — | US 75 / I-444 north – Bartlesville | Westbound exit and eastbound left entrance; entrance includes direct entrance ramp from 8th Street |
| Tulsa | Tulsa | 459.5 | 739.5 | — | Utica Avenue | Eastbound exit and westbound entrance |
| Tulsa | Tulsa | 460.0 | 740.3 | — | Lewis Avenue | No westbound exit |
| Tulsa | Tulsa | | | — | Peoria Avenue / Utica Avenue | Westbound exit and eastbound entrance |
| Tulsa | Tulsa | 460.3 | 740.8 | — | 15th Street | No eastbound entrance |
| Tulsa | Tulsa | 460.8 | 741.6 | — | 21st Street | |
| Tulsa | Tulsa | 461.5 | 742.7 | — | Harvard Avenue | |
| Tulsa | Tulsa | 462.6 | 744.5 | — | 31st Street / Yale Avenue – Fairgrounds, Expo Square | |
| Tulsa | Tulsa | 463.7 | 746.3 | — | Sheridan Road | |
| Tulsa | Tulsa | 464.2 | 747.1 | — | I-44 / SH-66 – Oklahoma City, Joplin | Cloverleaf interchange; I-44 exit 231 |
| Tulsa | Tulsa | 464.9 | 748.2 | — | Memorial Drive | Eastbound exit includes direct exit ramp onto 38th Street |
| Tulsa | Tulsa | 465.5 | 749.1 | — | Mingo Road | No westbound exit |
| Tulsa | Tulsa | 466.4 | 750.6 | — | US 169 north (Mingo Valley Expressway north) / SH-51 east (Broken Arrow Expressway east) – Owasso, Broken Arrow, Muskogee via SH-351 (Turnpike) | Eastern end of SH-51 concurrency; western end of US-169 concurrency |
| Tulsa | Tulsa | 467.1 | 751.7 | — | 51st Street South | |
| Tulsa | Tulsa | 468.1 | 753.3 | — | 61st Street South | |
| Tulsa | Tulsa | 469.1 | 754.9 | — | 71st Street South | |
| Tulsa | Tulsa | 469.9 | 756.2 | — | 81st Street South | |
| Tulsa | Tulsa | 470.6 | 757.4 | — | Creek Turnpike east – Broken Arrow | Eastbound exit and westbound entrance |
| Tulsa | Tulsa | 471.1 | 758.2 | — | 91st Street South | No westbound exit |
| Tulsa | Tulsa | 471.7 | 759.1 | — | US 169 ends / Creek Turnpike east – Broken Arrow, Joplin | Southern terminus of US-169; eastern end of US-169 concurrency; northern end of Creek Tpk. concurrency |
| Tulsa | Tulsa | 471.8 | 759.3 | — | Mingo Road | Westbound exit only |
| Tulsa | Tulsa | 472.3 | 760.1 | | Creek Turnpike west | Southern end of Creek Tpk. concurrency; east end of controlled-access section |
| Tulsa | Bixby | 478.3 | 769.7 | | SH-67 west | Eastern terminus of SH-67 |
| Wagoner | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions | No major junctions |
| Muskogee | Haskell | 495.3 | 797.1 | | SH-72 north | Western end of SH-72 concurrency |
| Muskogee | Haskell | 495.6 | 797.6 | | SH-104 | Western terminus of SH-104 |
| Muskogee | ​ | 501.6 | 807.2 | | US 62 east / SH-72 south / SH-16 east | Eastern end of SH-72 concurrency; western end of US-62/SH-16 concurrency |
| Muskogee | ​ | 506.6 | 815.3 | | SH-162 | Southern terminus of SH-162 |
| Muskogee | Muskogee | 515.4 | 829.5 | | US 62 / SH-16 east / US 69 north (32nd Street north) / US 62 Bus. east (US 64 Bus. east) | Eastern end of US-62/SH-16 concurrency, Western end of US-69 concurrency, western terminus of US-62 Bus. and US-69 Bus. |
| Muskogee | Muskogee | 518.4 | 834.3 | | US 69 | Interchange; Eastern end of US-69 concurrency |
| Muskogee | Muskogee | 519.8 | 836.5 | | SH-165 east (Peak Boulevard east) / US 64 Bus. west | Interchange; western terminus of SH-165; eastern terminus of US-64 Bus. |
| Muskogee | Muskogee | | | | To SH-165 | Interchange; westbound exit only |
| Muskogee | Warner | 535.9 | 862.4 | | US 266 west / SH-2 south to I-40 | Eastern terminus of US-266; northern terminus of SH-2 |
| Muskogee | Webbers Falls | 543.9 | 875.3 | | Muskogee Turnpike | Access to westbound and from eastbound Muskogee Tpk. only, Muskogee Tpk. exit 55 |
| Muskogee | Webbers Falls | 545.6 | 878.1 | | SH-100 south | Western end of SH-100 concurrency |
| Sequoyah | Gore | 547.9 | 881.8 | | SH-10 / SH-100 north (Main Street north) | Eastern end of SH-100 concurrency, western end of SH-10 concurrency |
| Sequoyah | ​ | 550.5 | 885.9 | | SH-10 south | Eastern end of SH-10 concurrency |
| Sequoyah | Vian | 556.8 | 896.1 | | SH-82 | |
| Sequoyah | Sallisaw | 567.1 | 912.7 | | US 59 south / I-40 BL west (Kerr Boulevard) | Western end of US-59/I-40 Bus. concurrency |
| Sequoyah | Sallisaw | 568.2 | 914.4 | | US 59 north (Wheeler Street) | Eastern end of US-59 concurrency |
| Sequoyah | Sallisaw | 570.1 | 917.5 | | I-40 BL ends / I-40 – Oklahoma City, Ft. Smith | Eastern end of I-40 Bus. concurrency; I-40 exit 311 |
| Sequoyah | ​ | 576.2 | 927.3 | | SH-141 | Northern terminus of SH-141 |
| Sequoyah | Muldrow | 580.4 | 934.1 | | SH-64B | Southern terminus of SH-64B |
| Sequoyah | Roland | 584.5 | 940.7 | | I-40 – Oklahoma City, Little Rock | I-40 exit 325 |
| Sequoyah | ​ | 589.0 | 947.9 | | SH-64D | Trumpet interchange, southern terminus of SH-64D |
| Sequoyah | ​ | 589.6 | 948.9 | | Moffett Stockyards | Parclo interchange |
| Arkansas River | Arkansas River | 590.1 | 949.7 | | J. Fred Patton Garrison Street Bridge Oklahoma–Arkansas line | J. Fred Patton Garrison Street Bridge Oklahoma–Arkansas line |
| Arkansas River | Arkansas River | 590.1 | 949.7 | | US 64 east – Fort Smith | Continuation into Arkansas |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi Concurrency terminus Incomplete access Tolled |||||||

## Spur routes

Near the east end of its route through Oklahoma, US-64 currently connects to two short highways, bearing the number "64" with a letter suffix, branching off from the interstate to connect the highway to other roads. Both of these highways lie entirely within Sequoyah County and connect US-64 to I-40.
In the past, US-64 also connected to a short spur highway in Perry.

### SH-64A

State Highway 64A began at I-35 exit 186 and extended east into Perry for approximately two miles (3.2 km). SH-64A first appeared on the official state highway map in 1965, though it was not labeled as SH-64A until the 1966 edition.
When US-64 was realigned around 1971, US-64 was realigned to follow SH-64A through Perry. The SH-64A designation was retired at this time.

### SH-64B

State Highway 64B begins at I-40 exit 321 in Muldrow and heads north along Main Street, connecting with US-64 0.6 miles (0.97 km) north of the interstate. From here, the highway continues north along Main Street through downtown Muldrow. After passing through downtown, SH-64B leaves the city limits and proceeds north to unincorporated Long. North of Long, it comes to its northern terminus at SH-101. SH-64B's total length is 11.39 miles (18.33 km).
SH-64B first appeared on the 1959 state highway map as a gravel highway. By 1962, the southern half of the highway had been paved. The remainder of the highway was paved by the following year.

### SH-64C

State Highway 64C was a short state highway in Sequoyah County that existed briefly in the early 1970s. SH-64C began at SH-64B north of Muldrow. From here, it proceeded southeast in a stairstep fashion, using a mix of gravel and paved roads, to Roland. From Roland, it continued south, crossing I-40 and coming to its eastern terminus at US-64. Its length was nine miles (14 km).
SH-64C first appeared on the 1974 state highway map. By the following year, the portion of highway between downtown Roland and US-64 had been removed from the state highway system, bringing its length down to eight miles (13 km). It had been removed from the state highway system in its entirety by 1976.

### SH-64D

State Highway 64D is a highway beginning at US-64 in Moffett, running parallel to the Oklahoma–Arkansas state line to its northern terminus at I-40 exit 330 just west of Dora, Arkansas. SH-64D is 3.65 miles (5.87 km) long.
SH-64D first appeared on the 1974 state map. At that time, the highway had a gravel road surface. By the next year, it had been paved in its entirety.