# List of Major League Baseball players from Puerto Rico

Puerto Rico currently has the fourth-most active players in Major League Baseball (MLB) among Latin American jurisdictions, behind the Dominican Republic, Venezuela and Cuba. More than three hundred players from the archipelago have played in the major leagues since 1926. This includes players who were born in either one of the archipelago's islands and those of Puerto Rican heritage. Only those players who have worked in the major leagues are listed, not those active in the minor leagues, nor negro independent leagues.
For years, it was considered that the first player from Puerto Rico to play in the major leagues was Hiram Bithorn in 1942. But this changed in December 2020, when seven Negro baseball leagues between 1920 and 1948 were recognized as "major leagues." Thus, the first Puerto Rican to play baseball on the major leagues was Jose "Gacho" Torres, who debuted in 1926.
After the baseball color line was abandoned following Jackie Robinson's debut in the National League of MLB, more players from the island signed contracts. This led to an improvement in their performance, and some of them were selected to participate in the Major League Baseball All-Star Game. Including their names in the Major League Baseball draft is a requisite for first-year players born in Puerto Rico, because the league recognizes the island as a jurisdiction within the United States. Following the implementation of this measure, Puerto Rico's government requested exclusion from the draft and help to develop players, in order to reduce the impact of the change in the format of talent development.

## Historical performance and regulations

Baseball was introduced to Puerto Rico by immigrants during the nineteenth century. The first sanctioned baseball game in the island was played on January 9, 1898, in Santurce, Puerto Rico, where two teams composed of Puerto Rican, American and Cuban players participated. After this game, baseball became a widespread sport and professional and amateur leagues were organized. During this time period, the Puerto Rico national teams experienced success on international competition and Afro-Puerto Rican players began to participate in the Negro leagues.
Hiram Bithorn debuted as a pitcher with the Chicago Cubs on April 15, 1942, but before him, there were about 10 other players who worked on the negro leagues, now considered as major leagues. About 17 other Puerto Rican players in the negro leagues were active right before the introduction of African American players in Major League Baseball, and thus, there were more chances to players born in the island. Subsequently, Afro-Puerto Rican players such as Orlando Cepeda and Victor Pellot Power began having solid performances in the league, and were selected to participate in the Major League Baseball All-Star Game. In 1973, Roberto Clemente became the first player from Puerto Rico and first Latin American to be elected as a member of the National Baseball Hall of Fame and Museum. Since then Puerto Rico has kept a stable number of players in the league. During this timeframe, several players have been selected to participate in the All-Star Game or won awards for their performance, while others imposed records within the league. These include Javy López, who holds the record for most home runs hit by a catcher in a single season. Both Iván Rodríguez and Roberto Alomar hold the record for most Gold Glove Awards in their positions. Recipients of the Most Valuable Player Award include Orlando Cepeda, Juan González and Iván Rodríguez. Roberto Clemente and Mike Lowell also won the World Series MVP Award in their respective divisions. Carlos Delgado is the only Latin to hit 4 homers in a game.
Originally, players who were either born or naturalized in Puerto Rico were able to sign with MLB teams as free agents, usually receiving minor-league contracts prior to their debut in the league. In 1989, Major League Baseball decided to include the island in the list of jurisdictions within the United States, which made mandatory that first-year players include their name in the Major League Baseball Draft in order to receive a contract. This was based on an initiative that was supposed to create a national and international drafting system. The change reduced the number of players that were able to participate in the league, by limiting the number of them selected by the teams; this led to the island's Secretary of Recreation and Sports, to formally ask to Major League's involvement in developing specialized schools to produce more players and other measures to reduce the impact of the draft's implementation. The original proposal included Puerto Rico's exclusion of the draft for a period of ten years, but this was not approved by the league.
Puerto Rico was one of sixteen teams to participate in the inaugural edition of the World Baseball Classic. The tournament was created by Major League Baseball, the Major League Baseball Players Association, and other professional baseball leagues and their players associations around the world, including the Puerto Rican Professional Baseball League. The first event was organized in 2006, and was sanctioned by the International Baseball Federation. Puerto Rico won the silver medal on both 2013 and 2017 classics. The Hiram Bithorn Stadium in San Juan, Puerto Rico hosted 22 Montreal Expos home games in 2003, after the league decided to relocate the team to San Juan as part of an experiment to "globalize" baseball. During the series there was an average attendance of 14,222.

## List of players

This list includes players born in Puerto Rico and players born outside of Puerto Rico to a Puerto Rican parent.

### A–E

| Name | Debut team | Years active |
| Juan Agosto | Chicago White Sox | 1981–1993 |
| Luis Aguayo | Philadelphia Phillies | 1980–1989 |
| Jonathan Albaladejo | Washington Nationals | 2007–2012 |
| José Alberro | Texas Rangers | 1995–1997 |
| Luis Alcaraz | Los Angeles Dodgers | 1967–1970 |
| Luis Alicea | St. Louis Cardinals | 1988–2002 |
| Sandy Alomar Jr. | San Diego Padres | 1988–2007 |
| Sandy Alomar Sr. | Milwaukee Braves | 1964–1978 |
| Roberto Alomar | San Diego Padres | 1988–2004 |
| Luis Alvarado | Boston Red Sox | 1968–1977 |
| Orlando Álvarez | Los Angeles Dodgers | 1973–1976 |
| Robert Andino | Florida Marlins | 2005–2013 |
| Luis Aquino | Toronto Blue Jays | 1986–1995 |
| Jake Arrieta | Baltimore Orioles | 2010–2022 |
| Christian Arroyo | San Francisco Giants | 2017–present |
| Luis Arroyo | St. Louis Cardinals | 1955–1963 |
| Rudy Arroyo | St.Louis Cardinals | 1971 |
| Luis Atilano | Washington Nationals | 2010 |
| Mike Avilés | Kansas City Royals | 2011–2017 |
| Ramón Avilés | Boston Red Sox | 1977–1981 |
| Benny Ayala | New York Mets | 1974–1985 |
| Carlos Baerga | Cleveland Indians | 1990–2005 |
| Javier Báez | Chicago Cubs | 2014–present |
| Kevin Baez | New York Mets | 1990–1993 |
| Aaron Bates | Boston Red Sox | 2009 |
| Carlos Beltrán | Kansas City Royals | 1998–2017 |
| Juan Beníquez | Boston Red Sox | 1971–1987 |
| Yamil Benítez | Montreal Expos | 1995–1998 |
| Jonathan Bermúdez | Miami Marlins | 2024 |
| Tony Bernazard | Montreal Expos | 1979–1991 |
| Carlos Bernier | Pittsburgh Pirates | 1953 |
| José Berríos | Minnesota Twins | 2016–present |
| Hiram Bithorn | Chicago Cubs | 1942–1947 |
| Hiram Bocachica | Los Angeles Dodgers | 2000–2007 |
| Ricky Bones | San Diego Padres | 1991–2001 |
| Bobby Bonilla | Chicago White Sox | 1986–2001 |
| Juan Bonilla | San Diego Padres | 1981–1987 |
| Hiram Burgos | Milwaukee Brewers | 2013 |
| Fernando Cabrera | Cleveland Indians | 2004–2010 |
| Luis Cabrera | Indianapolis Clowns | 1948 |
| Ivan Calderón | Seattle Mariners | 1984–1993 |
| Kiko Calero | St. Louis Cardinals | 2003–2009 |
| Luis Campusano | San Diego Padres | 2020–2021 |
| Robinson Cancel | Milwaukee Brewers | 1999–2011 |
| John Candelaria | Pittsburgh Pirates | 1975–1993 |
| John Cangelosi | Chicago White Sox | 1985–1999 |
| Víctor Caratini | Chicago Cubs | 2017–present |
| Javier Cardona | Detroit Tigers | 2000–2002 |
| Rafael Carmona | Seattle Mariners | 1995–1999 |
| Raúl Casanova | Detroit Tigers | 1996–2009 |
| Ramón Castro | Florida Marlins | 1999–2011 |
| Willi Castro | Detroit Tigers | 2019–2021 |
| Xavier Cedeño | Washington Nationals | 2011–2019 |
| Juan Centeno | New York Mets | 2013–2019 |
| Orlando Cepeda | San Francisco Giants | 1958–1974 |
| Leonardo Chapman | Baltimore Elite Giants | 1944 |
| Alex Cintrón | Arizona Diamondbacks | 2001–2010 |
| Alex Claudio | Texas Rangers | 2014–2021 |
| Edgard Clemente | Colorado Rockies | 1998–2000 |
| Roberto Clemente | Pittsburgh Pirates | 1955–1972 |
| Jaime Cocanower | Milwaukee Brewers | 1983–1986 |
| Pancho Coimbre | New York Cubans | 1940–1944 |
| Willie Collazo | New York Mets | 2007 |
| Christian Colón | Kansas City Royals | 2014–2020 |
| Joe Colón | Cleveland Indians | 2016 |
| Monchile Concepción | Phila. Bacharach Giants | 1934 |
| Onix Concepción | Kansas City Royals | 1980–1987 |
| Ramón Conde | Chicago White Sox | 1962 |
| Alex Cora | Los Angeles Dodgers | 1998–2011 |
| Joey Cora | San Diego Padres | 1987–1998 |
| Wil Cordero | Montreal Expos | 1992–2005 |
| Carlos Corporán | Houston Astros | 2009–2015 |
| Carlos Correa | Houston Astros | 2015–present |
| Edwin Correa | Chicago White Sox | 1985–1987 |
| Fernando Cortez | Tampa Bay Devil Rays | 2005–2007 |
| Henry Cotto | Chicago Cubs | 1984–1993 |
| César Crespo | San Diego Padres | 2001–2004 |
| Felipe Crespo | Toronto Blue Jays | 1996–2001 |
| Fernando Cruz | Cincinnati Reds | 2022 |
| Héctor Cruz | St. Louis Cardinals | 1973–1982 |
| Henry Cruz | Los Angeles Dodgers | 1975–1978 |
| Julio Cruz | Seattle Mariners | 1977–1986 |
| Iván Cruz | New York Yankees | 1997–2002 |
| José Cruz | St. Louis Cardinals | 1970–1988 |
| José Cruz Jr. | Seattle Mariners | 1997–2008 |
| Cirilo "Tommy" Cruz | St. Louis Cardinals | 1973–1977 |
| Noel Cuevas | Colorado Rockies | 2018–2019 |
| David DeJesus | Kansas City Royals | 2003–2015 |
| José DeJesús | Kansas City Royals | 1988–1994 |
| Iván DeJesús | Los Angeles Dodgers | 1974–1988 |
| Iván DeJesús Jr. | Los Angeles Dodgers | 2011–2016 |
| José De La Torre | Boston Red Sox | 2013 |
| José De León | Los Angeles Dodgers | 2016–2021 |
| Luis DeLeón | St. Louis Cardinals | 1981–1989 |
| Carlos Delgado | Toronto Blue Jays | 1993–2009 |
| Felle Delgado | New York Cubans | 1941 |
| Puchy Delgado | Seattle Mariners | 1977 |
| Alex Díaz | Milwaukee Brewers | 1992–1999 |
| Alexis Díaz | Cincinnati Reds | 2022 |
| Carlos Diaz | Atlanta Braves | 1982–1986 |
| Edgar Díaz | Milwaukee Brewers | 1986–1990 |
| Edwin Díaz | Arizona Diamondbacks | 1998–1999 |
| Edwin Díaz | New York Mets | 2016–present |
| Isan Díaz | Miami Marlins | 2019–2020 |
| Jonathan Diaz | Boston Red Sox | 2013–2015 |
| Mario Díaz | Seattle Mariners | 1987–1995 |
| Mike Díaz | Chicago Cubs | 1983–1988 |
| Angel Echevarría | Colorado Rockies | 1996–2002 |
| Christian Encarnacion-Strand | Cincinnati Reds | 2023 |
| Nino Escalera | Cincinnati Redlegs | 1954 |
| José Espada | San Diego Padres | 2023 |

### F–L

| Name | Debut team | Years active |
| Irving Falú | Kansas City Royals | 2012–2014 |
| Johneshwy Fargas | New York Mets | 2021 |
| Jesús Feliciano | New York Mets | 2010 |
| Mario Feliciano | Milwaukee Brewers | 2021 |
| Pedro Feliciano | New York Mets | 2002–2013 |
| Coco Ferrer | Indianapolis Clowns | 1946–1948 |
| Sergio Ferrer | Minnesota Twins | 1974–1979 |
| Ed Figueroa | California Angels | 1974–1981 |
| Luis Figueroa | Pittsburgh Pirates | 2001–2007 |
| Nelson Figueroa | Arizona Diamondbacks | 2000–2011 |
| Tite Figueroa | Baltimore Elite Giants | 1946 |
| Tito Figueroa | New York Cubans | 1940 |
| Gil Flores | California Angels | 1977–1979 |
| Jose Flores | Oakland Athletics | 2002–2004 |
| Miguel Fuentes | Seattle Pilots | 1969 |
| Rey Fuentes | San Diego Padres | 2013–2017 |
| Jason Garcia | Baltimore Orioles | 2015 |
| Pedro García | Milwaukee Brewers | 1973–1977 |
| Rico Garcia | Colorado Rockies | 2019–2020 |
| Mychal Givens | Baltimore Orioles | 2015–present |
| Leo Gómez | Baltimore Orioles | 1990–1996 |
| Rubén Gómez | New York Giants | 1953–1962 |
| Andy González | Chicago White Sox | 2007–2009 |
| Dicky Gonzalez | New York Mets | 2001–2004 |
| Fernando González | Pittsburgh Pirates | 1972–1979 |
| Juan González | Texas Rangers | 1989–2005 |
| Julio González | Houston Astros | 1977–1983 |
| Pedro González | New York Yankees | 1963–1967 |
| Raúl González | Chicago Cubs | 2000–2004 |
| Julio Gotay | St. Luis Cardinals | 1960–1969 |
| Rubén Gotay | Kansas City Royals | 2004–2008 |
| Riley Greene | Detroit Tigers | 2022 |
| Vaughn Grissom | Atlanta Braves | 2022 |
| Felix Guilbe | Baltimore Elite Giants | 1946–1947 |
| Juan Guilbe | New York Cubans | 1940–1947 |
| Edwards Guzmán | San Francisco Giants | 1999–2003 |
| José Guzmán | Texas Rangers | 1985–1994 |
| Von Hayes | Cleveland Indians | 1981–1992 |
| Darell Hernáiz | Oakland Athletics | 2024 |
| Jesús Hernáiz | Philadelphia Phillies | 1974 |
| Alex Hernández | Pittsburgh Pirates | 2000–2001 |
| Enrique Hernández | Miami Marlins | 2014–present |
| José Hernández | Texas Rangers | 1991–2006 |
| Ramón Hernández | Atlanta Braves | 1967–1977 |
| Roberto Hernández | Chicago White Sox | 1991–2007 |
| Rudy Hernández | Washington Senators | 1960–1961 |
| Willie Hernández | Chicago Cubs | 1977–1989 |
| Orlando Isales | Philadelphia Phillies | 1980 |
| Josh James | Houston Astros | 2018–present |
| Mike James | California Angels | 1995–2002 |
| A. J. Jiménez | Texas Rangers | 2017 |
| Joe Jiménez | Atlanta Braves | 2017–present |
| Ricardo Jordan | Toronto Blue Jays | 1995–1998 |
| Marc Kroon | San Diego Padres | 1995–2004 |
| Coco Laboy | Montreal Expos | 1969–1973 |
| Alex Lange | Detroit Tigers | 2021–present |
| Ricky Ledée | New York Yankees | 1998–2007 |
| José León | Baltimore Orioles | 2002–2004 |
| Carlos Lezcano | Chicago Cubs | 1980–1981 |
| Sixto Lezcano | Milwaukee Brewers | 1974–1985 |
| Frankie Librán | San Diego Padres | 1969 |
| José Lind | Pittsburgh Pirates | 1987–1995 |
| Francisco Lindor | New York Mets | 2015–present |
| Art López | New York Yankees | 1965 |
| Felipe López | Toronto Blue Jays | 2001–2011 |
| Jack López | Boston Red Sox | 2021 |
| Javier López | Colorado Rockies | 2003–2016 |
| Javy López | Atlanta Braves | 1992–2006 |
| Jorge López | Milwaukee Brewers | 2015–present |
| Luis Lopez | Los Angeles Dodgers | 1990–1991 |
| Luis López | San Diego Padres | 1993–2005 |
| Luis Lopez | Toronto Blue Jays | 2001–2004 |
| Raffy Lopez | Chicago Cubs | 2014–2018 |
| Mike Lowell | Boston Red Sox | 1998–2010 |
| Willie Lozado | Milwaukee Brewers | 1984 |
| Seth Lugo | New York Mets | 2016–present |

### M–Q

| Name | Debut team | Years active |
| Vimael Machin | Oakland Athletics | 2020–2021 |
| Anthony Maldonado | Miami Marlins | 2024 |
| Candy Maldonado | Los Angeles Dodgers | 1981–1995 |
| Martín Maldonado | Milwaukee Brewers | 2011–present |
| Ángel Mangual | Pittsburgh Pirates | 1969–1976 |
| Pepe Mangual | Montreal Expos | 1972–1977 |
| Félix Mantilla Lamela | Milwaukee Braves | 1956–1966 |
| Robert Manuel | Cincinnati Reds | 2009–2010 |
| Luis Márquez | Homestead Grays | 1946–1954 |
| Oreste Marrero | Montreal Expos | 1993–1996 |
| Carmelo Martínez | Chicago Cubs | 1983–1991 |
| Dave Martínez | Chicago Cubs | 1986–2001 |
| Edgar Martínez | Seattle Mariners | 1987–2004 |
| Javier Martínez | Pittsburgh Pirates | 1998 |
| Ozzie Martínez | Florida Marlins | 2010–2011 |
| Ramón Martínez | San Francisco Giants | 1998–2009 |
| Damon Mashore | Oakland Athletics | 1996–1998 |
| Julius Matos | San Diego Padres | 2002–2003 |
| Luis Matos | Baltimore Orioles | 2000–2006 |
| Edwin Maysonet | Houston Astros | 2008–2012 |
| Francisco Meléndez | Philadelphia Phillies | 1984–1989 |
| José Meléndez | Seattle Mariners | 1990–1994 |
| Luis Meléndez | St. Louis Cardinals | 1970–1977 |
| MJ Melendez | Kansas City Royals | 2022–present |
| Héctor Mercado | Cincinnati Reds | 2000–2003 |
| Orlando Mercado | Seattle Mariners | 1982–1990 |
| Orlando Merced | Pittsburgh Pirates | 1990–2003 |
| Félix Millán | Atlanta Braves | 1966–1977 |
| Ángel Miranda | Milwaukee Brewers | 1993–1997 |
| José Miranda | Minnesota Twins | 2022–present |
| Bengie Molina | Anaheim Angels | 1998–2010 |
| José Molina | Chicago Cubs | 1999–2014 |
| Yadier Molina | St. Louis Cardinals | 2004–2022 |
| Johnny Monell | San Francisco Giants | 2013–2015 |
| Rafael Montalvo | Houston Astros | 1986 |
| Lou Montañez | Baltimore Orioles | 2008–2011 |
| Willie Montañez | California Angels | 1966–1982 |
| Charlie Montoyo | Montreal Expos | 1993 |
| Dan Monzon | Minnesota Twins | 1972–1973 |
| Jerry Morales | San Diego Padres | 1969–1983 |
| José Morales | Minnesota Twins | 2007–2011 |
| José Morales | Oakland Athletics | 1973–1984 |
| Jovani Moran | Minnesota Twins | 2021 |
| Roger Moret | Boston Red Sox | 1970–1978 |
| Steven Moya | Detroit Tigers | 2014–2016 |
| Manny Muñiz | Philadelphia Phillies | 1971 |
| Jose Munoz | Chicago White Sox | 1996 |
| Bobby Muñoz | New York Yankees | 1993–2001 |
| Pedro Muñoz | Minnesota Twins | 1990–1996 |
| Bob Natal | Montreal Expos | 1992–1997 |
| Brian Navarreto | Miami Marlins | 2020 |
| Jaime Navarro | Milwaukee Brewers | 1989–2000 |
| Julio Navarro | Los Angeles Angels | 1962–1970 |
| Millito Navarro | Cuban Stars East | 1928–1929 |
| Rey Navarro | Baltimore Orioles | 2015 |
| Tito Navarro | New York Mets | 1993 |
| Kristopher Negrón | Cincinnati Reds | 2012–2019 |
| Tomás Nido | New York Mets | 2017–present |
| Juan Nieves | Milwaukee Brewers | 1986–1988 |
| Melvin Nieves | Atlanta Braves | 1992–1998 |
| Wil Nieves | San Diego Padres | 2002–2015 |
| Rafael Novoa | San Francisco Giants | 1990–1993 |
| Edwin Núñez | Seattle Mariners | 1982–1994 |
| Ed Olivares | St. Louis Cardinals | 1960–1961 |
| Omar Olivares | St. Louis Cardinals | 1990–2001 |
| Francisco Oliveras | Minnesota Twins | 1989–1992 |
| Luis Rodríguez Olmo | Brooklyn Dodgers | 1943–1951 |
| José Oquendo | New York Mets | 1983–1995 |
| Danny Ortiz | Pittsburgh Pirates | 2017 |
| Héctor Ortiz | Kansas City Royals | 1998–2002 |
| José Ortiz | Chicago White Sox | 1969–1971 |
| Junior Ortíz | Pittsburgh Pirates | 1982–1994 |
| Rafaelito Ortiz | Chicago American Giants | 1948 |
| Ricky Otero | New York Mets | 1995–1997 |
| Jorge Padilla | Washington Nationals | 2009 |
| Juan Padilla | New York Yankees | 2004–2005 |
| Nicholas Padilla | Chicago Cubs | 2022 |
| Ángel Pagán | Chicago Cubs | 2006–2016 |
| Emilio Pagán | San Diego Padres | 2017–present |
| José Pagán | San Francisco Giants | 1959–1973 |
| Josh Palacios | Toronto Blue Jays | 2021 |
| Rey Palacios | Kansas City Royals | 1988–1990 |
| Richie Palacios | Cleveland Guardians | 2022 |
| Sam Parrilla | Philadelphia Phillies | 1970 |
| Victor Pellot | Philadelphia Athletics | 1954–1965 |
| Bert Peña | Houston Astros | 1981–1987 |
| Jim Pena | San Francisco Giants | 1992 |
| Luis Peraza | Philadelphia Phillies | 1969 |
| Jose Pereira | Baltimore Elite Giants | 1947 |
| Eduardo Perez | California Angels | 1993–2006 |
| Luis Pérez | Indianapolis Clowns | 1948 |
| Michael Pérez | Tampa Bay Rays | 2018–present |
| Mike Pérez | St. Louis Cardinals | 1990–1997 |
| Roberto Pérez | Cleveland Indians | 2014–present |
| Luis Pillot | New York Black Yankees | 1941–43 |
| Joel Piñeiro | Seattle Mariners | 2000–2011 |
| Juan Pizarro | Milwaukee Braves | 1957–1974 |
| Rafael Polanco | Newark Eagles | 1941 |
| Carlos Ponce | Milwaukee Brewers | 1985 |
| Simon Pond | Toronto Blue Jays | 2004 |
| Arnie Portocarrero | Philadelphia Athletics | 1954–1960 |
| Jorge Posada | New York Yankees | 1995–2011 |
| Luis Quiñones | Oakland Athletics | 1983–1992 |
| Rey Quiñones | Boston Red Sox | 1986–1989 |
| Tomás Quiñones | Indianapolis Clowns | 1947 |
| Luis Quintana | California Angels | 1974–1975 |

### R–W

| Name | Debut team | Years active |
| Mario Ramírez | New York Mets | 1980–1985 |
| Milt Ramírez | St. Louis Cardinals | 1970–1979 |
| Heliot Ramos | San Francisco Giants | 2022 |
| Henry Ramos | Arizona Diamondbacks | 2021, 2023 |
| Vidal Richardson | Cleveland Buckeyes | 1946 |
| Alex Ríos | Toronto Blue Jays | 2004–2015 |
| Armando Ríos | San Francisco Giants | 1998–2003 |
| Edwin Ríos | Los Angeles Dodgers | 2019–2021 |
| Juan Ríos | Kansas City Royals | 1969 |
| Yacksel Ríos | Philadelphia Phillies | 2017–2021 |
| Bombo Rivera | Montreal Expos | 1975–1982 |
| Carlos Rivera | Pittsburgh Pirates | 2003–2004 |
| Charlie Rivera | Baltimore Elite Giants | 1939–1944 |
| Emmanuel Rivera | Kansas City Royals | 2021–present |
| Germán Rivera | Los Angeles Dodgers | 1983–1985 |
| Jim Rivera | St. Louis Browns | 1952–1961 |
| Luis Rivera | Montreal Expos | 1986–1998 |
| Mike Rivera | Detroit Tigers | 2001–2011 |
| René Rivera | Seattle Mariners | 2004–2021 |
| Roberto Rivera | Chicago Cubs | 1995–1999 |
| Saúl Rivera | Washington Nationals | 2006–2010 |
| T.J. Rivera | New York Mets | 2016–2017 |
| Yadiel Rivera | Milwaukee Brewers | 2015–2020 |
| Benny Rodríguez | Chicago American Giants | 1948 |
| Dereck Rodríguez | San Francisco Giants | 2018–present |
| Eduardo Rodríguez | Milwaukee Brewers | 1973–1979 |
| Edwin Rodríguez | New York Yankees | 1982–1985 |
| Ellie Rodríguez | New York Yankees | 1968–1976 |
| Frank Rodríguez | Boston Red Sox | 1995–2001 |
| Iván Rodríguez | Texas Rangers | 1991–2010 |
| John Rodríguez | St. Louis Cardinals | 2005–2006 |
| Johnathan Rodriguez | Cleveland Guardians | 2024 |
| José Rodríguez | St. Louis Cardinals | 2000–2002 |
| Steve Rodriguez | Boston Red Sox | 1995 |
| Tony Rodríguez | Boston Red Sox | 1996 |
| Victor Rodríguez | Baltimore Orioles | 1984–1989 |
| Ed Romero | Milwaukee Brewers | 1977–1989 |
| J. C. Romero | Minnesota Twins | 1999–2012 |
| Gil Rondón | Houston Astros | 1976–1979 |
| Jorge Roque | St. Louis Cardinals | 1970–1973 |
| Jose Rosado | Kansas City Royals | 1996–2000 |
| Luis Rosado | New York Mets | 1977–1980 |
| Eddie Rosario | Minnesota Twins | 2015–present |
| Jimmy Rosario | San Francisco Giants | 1971–1976 |
| Santiago Rosario | Kansas City Athletics | 1965 |
| Dave Rosello | Chicago Cubs | 1972–1981 |
| Rico Rossy | Atlanta Braves | 1991–1998 |
| Chico Ruiz | Atlanta Braves | 1978–1980 |
| Randy Ruiz | Minnesota Twins | 2008–2010 |
| Ángel Sánchez | Kansas City Royals | 2006–2013 |
| Jonathan Sánchez | San Francisco Giants | 2006–2013 |
| Orlando Sánchez | St. Louis Cardinals | 1981–1984 |
| Rey Sánchez | Chicago Cubs | 1991–2005 |
| Benito Santiago | San Diego Padres | 1986–2005 |
| Carlos Santiago | New York Cubans | 1946 |
| Héctor Santiago | Chicago White Sox | 2011–present |
| José "Pantalones" Santiago | New York Cubans | 1948–1956 |
| José "Palillo" Santiago | Kansas City Athletics | 1963–1970 |
| José Santiago | Kansas City Royals | 1997–2005 |
| Rafael Santo Domingo | Cincinnati Reds | 1979 |
| Ángel Santos | Boston Red Sox | 2001–2003 |
| Omir Santos | Baltimore Orioles | 2008–2013 |
| Candy Sierra | San Diego Padres | 1988 |
| Rubén Sierra | Texas Rangers | 1986–2006 |
| Jake Smith | San Diego Padres | 2016 |
| Ian Snell | Pittsburgh Pirates | 2004–2010 |
| Geovany Soto | Chicago Cubs | 2005–2017 |
| Giovanni Soto | Cleveland Indians | 2015 |
| Neftalí Soto | Cincinnati Reds | 2013–2014 |
| George Springer | Houston Astros | 2014–present |
| Marcus Stroman | Toronto Blue Jays | 2014–present |
| Danny Tartabull | Seattle Mariners | 1984–1997 |
| Valmy Thomas | New York Giants | 1957–1961 |
| Dickie Thon | California Angels | 1979–1993 |
| Andrés Torres | Detroit Tigers | 2002–2013 |
| Félix Torres | Los Angeles Angels | 1962–1964 |
| Gacho Torres | Newark Stars | 1926 |
| Rusty Torres | New York Yankees | 1971–1980 |
| Lou Trivino | Oakland Athletics | 2018–present |
| Duane Underwood Jr. | Chicago Cubs | 2018–present |
| Pedro Valdés | Chicago Cubs | 1996–2000 |
| Javier Valentín | Minnesota Twins | 1997–2008 |
| Jesmuel Valentín | Philadelphia Phillies | 2018 |
| John Valentin | Boston Red Sox | 1992–2002 |
| José Valentín | Milwaukee Brewers | 1992–2007 |
| Julio Valera | New York Mets | 1990–1996 |
| Héctor Valle | Los Angeles Dodgers | 1965 |
| Eddie Vargas | Pittsburgh Pirates | 1982–1984 |
| Kennys Vargas | Minnesota Twins | 2014–2017 |
| Roberto Vargas | Chicago American Giants | 1948–1955 |
| Christian Vázquez | Boston Red Sox | 2014–present |
| Javier Vázquez | Montreal Expos | 1998–2011 |
| Luis Vázquez | Chicago Cubs | 2024 |
| Ramón Vázquez | Seattle Mariners | 2001–2009 |
| Jesús Vega | Minnesota Twins | 1979–1982 |
| Andrew Velazquez | Tampa Bay Rays | 2018–present |
| Carlos Velázquez | Milwaukee Brewers | 1973 |
| Nelson Velázquez | Chicago Cubs | 2022 |
| Otto Vélez | New York Yankees | 1973–1983 |
| José Vidro | Montreal Expos | 1997–2008 |
| Mark Vientos | New York Mets | 2022–present |
| Vicente Villafañe | Indianapolis Clowns | 1947 |
| Héctor Villanueva | Chicago Cubs | 1990–1993 |
| Ismael Villegas | Atlanta Braves | 2000 |
| Luis Villodas | Baltimore Elite Giants | 1946–1947 |
| Ozzie Virgil Jr. | Philadelphia Phillies | 1980–1990 |
| Bernie Williams | New York Yankees | 1991–2006 |