# 2021 Daniil Medvedev tennis season

The 2021 Daniil Medvedev tennis season officially began on 2 January 2021, with the start of the ATP Cup.
The season saw him win his first grand slam at the 2021 US Open where he defeated then-world No. 1 Novak Djokovic in the final to deny him the calendar-year Grand Slam.

## All matches

This table chronicles all the matches of Daniil Medvedev in 2021.
Key :
| W | F | SF | QF | #R | RR | Q# | P# | DNQ | A | Z# | PO | G | S | B | NMS | NTI | P | NH |

### Singles matches

| Tournament | Match | Round | Opponent (seed or key) | Rank | Result | Score |
| ATP Cup Melbourne, Australia ATP Cup Hard, outdoor 2–7 February 2021 |
| ATP Cup Melbourne, Australia ATP Cup Hard, outdoor 2–7 February 2021 | 1 / 246 | RR | Diego Schwartzman | 9 | Win | 7–5, 6–3 |
| ATP Cup Melbourne, Australia ATP Cup Hard, outdoor 2–7 February 2021 | 2 / 247 | RR | Kei Nishikori | 41 | Win | 6–2, 6–4 |
| ATP Cup Melbourne, Australia ATP Cup Hard, outdoor 2–7 February 2021 | 3 / 248 | SF | Alexander Zverev (6) | 7 | Win | 3–6, 6–3, 7–5 |
| ATP Cup Melbourne, Australia ATP Cup Hard, outdoor 2–7 February 2021 | 4 / 249 | W | Matteo Berrettini | 10 | Win (1) | 6–4, 6–2 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 5 / 250 | 1R | Vasek Pospisil | 63 | Win | 6–2, 6–2, 6–4 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 6 / 251 | 2R | Roberto Carballés Baena | 99 | Win | 6–2, 7–5, 6–1 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 7 / 252 | 3R | Filip Krajinović (28) | 33 | Win | 6–3, 6–3, 4–6, 3–6, 6–0 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 8 / 253 | 4R | Mackenzie McDonald (PR) | 192 | Win | 6–4, 6–2, 6–3 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 9 / 254 | QF | Andrey Rublev (7) | 8 | Win | 7–5, 6–3, 6–2 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 10 / 255 | SF | Stefanos Tsitsipas (5) | 6 | Win | 6–4, 6–2, 7–5 |
| Australian Open Melbourne, Australia Grand Slam tournament Hard, outdoor 8–21 February 2021 | 11 / 256 | F | Novak Djokovic (1) | 1 | Loss | 5–7, 2–6, 2–6 |
| Rotterdam Open Rotterdam, Netherlands ATP Tour 500 Hard, indoor 1–7 March 2021 |
| Rotterdam Open Rotterdam, Netherlands ATP Tour 500 Hard, indoor 1–7 March 2021 | 12 / 257 | 1R | Dušan Lajović | 27 | Loss | 6–7$^{(4–7)}$, 4–6 |
| Marseille Open Marseille, France ATP Tour 250 Hard, indoor 8 – 14 March 2021 |
| Marseille Open Marseille, France ATP Tour 250 Hard, indoor 8 – 14 March 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Marseille Open Marseille, France ATP Tour 250 Hard, indoor 8 – 14 March 2021 | 13 / 258 | 2R | Egor Gerasimov | 76 | Win | 6–2, 6–4 |
| Marseille Open Marseille, France ATP Tour 250 Hard, indoor 8 – 14 March 2021 | 14 / 259 | QF | Jannik Sinner | 34 | Win | 6–2, 6–4 |
| Marseille Open Marseille, France ATP Tour 250 Hard, indoor 8 – 14 March 2021 | 15 / 260 | SF | Matthew Ebden (Q) | 287 | Win | 6–4, 3–0 ret. |
| Marseille Open Marseille, France ATP Tour 250 Hard, indoor 8 – 14 March 2021 | 16 / 261 | W | Pierre-Hugues Herbert | 93 | Win (2) | 6–4, 6–7$^{(4–7)}$, 6–4 |
| Miami Open Miami Gardens, United States ATP Tour Masters 1000 Hard, outdoor 22 March – 4 April 2021 |
| Miami Open Miami Gardens, United States ATP Tour Masters 1000 Hard, outdoor 22 March – 4 April 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Miami Open Miami Gardens, United States ATP Tour Masters 1000 Hard, outdoor 22 March – 4 April 2021 | 17 / 262 | 2R | Lu Yen-hsun (PR) | 1020 | Win | 6–2, 6–2 |
| Miami Open Miami Gardens, United States ATP Tour Masters 1000 Hard, outdoor 22 March – 4 April 2021 | 18 / 263 | 3R | Alexei Popyrin | 86 | Win | 7–6$^{(7–3)}$, 6–7$^{(7–9)}$, 6–4 |
| Miami Open Miami Gardens, United States ATP Tour Masters 1000 Hard, outdoor 22 March – 4 April 2021 | 19 / 264 | 4R | Frances Tiafoe | 58 | Win | 6–4, 6–3 |
| Miami Open Miami Gardens, United States ATP Tour Masters 1000 Hard, outdoor 22 March – 4 April 2021 | 20 / 265 | QF | Roberto Bautista Agut (7) | 12 | Loss | 4–6, 2–6 |
| Monte-Carlo Masters Monte Carlo, Monaco ATP Tour Masters 1000 Clay, outdoor 11–18 April 2021 |
| Withdrew ||||||
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 |
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 | 21 / 266 | 2R | Alejandro Davidovich Fokina (7) | 49 | Win | 4–6, 6–4, 6–2 |
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 | 22 / 267 | 3R | Cristian Garín (16) | 25 | Loss | 4–6, 7–6$^{(7–2)}$, 1–6 |
| Italian Open Rome, Italy ATP Tour Masters 1000 Clay, outdoor 9–16 May 2021 |
| Italian Open Rome, Italy ATP Tour Masters 1000 Clay, outdoor 9–16 May 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Italian Open Rome, Italy ATP Tour Masters 1000 Clay, outdoor 9–16 May 2021 | 23 / 268 | 2R | Aslan Karatsev | 27 | Loss | 2–6, 4–6 |
| French Open Paris, France Grand Slam tournament Clay, outdoor 30 May – 13 June 2021 |
| French Open Paris, France Grand Slam tournament Clay, outdoor 30 May – 13 June 2021 | 24 / 269 | 1R | Alexander Bublik | 37 | Win | 6–3, 6–3, 7–5 |
| French Open Paris, France Grand Slam tournament Clay, outdoor 30 May – 13 June 2021 | 25 / 270 | 2R | Tommy Paul | 52 | Win | 3–6, 6–1, 6–4, 6–3 |
| French Open Paris, France Grand Slam tournament Clay, outdoor 30 May – 13 June 2021 | 26 / 271 | 3R | Reilly Opelka (32) | 35 | Win | 6–4, 6–2, 6–4 |
| French Open Paris, France Grand Slam tournament Clay, outdoor 30 May – 13 June 2021 | 27 / 272 | 4R | Cristian Garín (22) | 23 | Win | 6–2, 6–1, 7–5 |
| French Open Paris, France Grand Slam tournament Clay, outdoor 30 May – 13 June 2021 | 28 / 273 | QF | Stefanos Tsitsipas (5) | 5 | Loss | 3–6, 6–7$^{(3–7)}$, 5–7 |
| Halle Open Halle, Germany ATP Tour 500 Grass, outdoor 14–20 June 2021 |
| Halle Open Halle, Germany ATP Tour 500 Grass, outdoor 14–20 June 2021 | 29 / 274 | 1R | Jan-Lennard Struff | 45 | Loss | 6–7$^{(6–8)}$, 3–6 |
| Mallorca Championships Mallorca, Spain ATP Tour 250 Grass, outdoor 21–26 June 2021 |
| Mallorca Championships Mallorca, Spain ATP Tour 250 Grass, outdoor 21–26 June 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Mallorca Championships Mallorca, Spain ATP Tour 250 Grass, outdoor 21–26 June 2021 | 30 / 275 | 2R | Corentin Moutet | 85 | Win | 6–4, 6–2 |
| Mallorca Championships Mallorca, Spain ATP Tour 250 Grass, outdoor 21–26 June 2021 | 31 / 276 | QF | Casper Ruud | 14 | Win | 7–5, 6–1 |
| Mallorca Championships Mallorca, Spain ATP Tour 250 Grass, outdoor 21–26 June 2021 | 32 / 277 | SF | Pablo Carreño Busta (4) | 13 | Win | 3–6, 6–3, 6–2 |
| Mallorca Championships Mallorca, Spain ATP Tour 250 Grass, outdoor 21–26 June 2021 | 33 / 278 | W | Sam Querrey | 60 | Win (3) | 6–4, 6–2 |
| Wimbledon Championships London, United Kingdom Grand Slam tournament Grass, outdoor 28 June – 11 July 2021 |
| Wimbledon Championships London, United Kingdom Grand Slam tournament Grass, outdoor 28 June – 11 July 2021 | 34 / 279 | 1R | Jan-Lennard Struff | 45 | Win | 6–4, 6–1, 4–6, 7–6$^{(7–3)}$ |
| Wimbledon Championships London, United Kingdom Grand Slam tournament Grass, outdoor 28 June – 11 July 2021 | 35 / 280 | 2R | Carlos Alcaraz (WC) | 75 | Win | 6–4, 6–1, 6–2 |
| Wimbledon Championships London, United Kingdom Grand Slam tournament Grass, outdoor 28 June – 11 July 2021 | 36 / 281 | 3R | Marin Čilić (32) | 37 | Win | 6–7$^{(3–7)}$, 3–6, 6–3, 6–3, 6–2 |
| Wimbledon Championships London, United Kingdom Grand Slam tournament Grass, outdoor 28 June – 11 July 2021 | 37 / 282 | 4R | Hubert Hurkacz (14) | 18 | Loss | 6–2, 6–7$^{(2–7)}$, 6–3, 3–6, 3–6 |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 | 38 / 283 | 1R | Alexander Bublik | 39 | Win | 6–4, 7–6$^{(10–8)}$ |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 | 39 / 284 | 2R | Sumit Nagal (ITF) | 160 | Win | 6–2, 6–1 |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 | 40 / 285 | 3R | Fabio Fognini (15) | 31 | Win | 6–2, 3–6, 6–2 |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 | 41 / 286 | QF | Pablo Carreño Busta (6) | 11 | Loss | 2–6, 6–7$^{(5–7)}$ |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 | 42 / 287 | 2R | Alexander Bublik | 39 | Win | 4–6, 6–3, 6–4 |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 | 43 / 288 | 3R | James Duckworth (Q) | 85 | Win | 6–2, 6–4 |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 | 44 / 289 | QF | Hubert Hurkacz (7) | 13 | Win | 2–6, 7–6$^{(8–6)}$, 7–6$^{(7–5)}$ |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 | 45 / 290 | SF | John Isner | 13 | Win | 6–2, 6–2 |
| Canadian Open Montreal, Canada ATP Tour Masters 1000 Hard, outdoor 6–15 August 2021 | 46 / 291 | W | Reilly Opelka | 13 | Win (4) | 6–4, 6–3 |
| Cincinnati Masters Cincinnati, United States ATP Tour Masters 1000 Hard, outdoor 16–22 August 2021 |
| Cincinnati Masters Cincinnati, United States ATP Tour Masters 1000 Hard, outdoor 16–22 August 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Cincinnati Masters Cincinnati, United States ATP Tour Masters 1000 Hard, outdoor 16–22 August 2021 | 47 / 292 | 2R | Mackenzie McDonald (WC) | 64 | Win | 6–2, 6–2 |
| Cincinnati Masters Cincinnati, United States ATP Tour Masters 1000 Hard, outdoor 16–22 August 2021 | 48 / 293 | 3R | Grigor Dimitrov | 21 | Win | 6–3, 6–3 |
| Cincinnati Masters Cincinnati, United States ATP Tour Masters 1000 Hard, outdoor 16–22 August 2021 | 49 / 294 | QF | Pablo Carreño Busta (7) | 12 | Win | 6–1, 6–1 |
| Cincinnati Masters Cincinnati, United States ATP Tour Masters 1000 Hard, outdoor 16–22 August 2021 | 50 / 295 | SF | Andrey Rublev (4) | 7 | Loss | 6–2, 3–6, 3–6 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 51 / 296 | 1R | Richard Gasquet | 79 | Win | 6–4, 6–3, 6–1 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 52 / 297 | 2R | Dominik Koepfer | 57 | Win | 6–4, 6–1, 6–2 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 53 / 298 | 3R | Pablo Andújar | 74 | Win | 6–0, 6–4, 6–3 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 54 / 299 | 4R | Dan Evans (24) | 27 | Win | 6–3, 6–4, 6–3 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 55 / 300 | SF | Botic van de Zandschulp (Q) | 117 | Win | 6–3, 6–0, 4–6, 7–5 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 56 / 301 | QF | Félix Auger-Aliassime (12) | 15 | Win | 6–4, 7–5, 6–2 |
| US Open New York City, United States Grand Slam tournament Hard, outdoor 30 August – 12 September 2021 | 57 / 302 | W | Novak Djokovic (1) | 1 | Win (5) | 6–4, 6–4, 6–4 |
| Laver Cup Boston, United States Laver Cup Hard, indoor 24 – 26 September 2021 |
| Laver Cup Boston, United States Laver Cup Hard, indoor 24 – 26 September 2021 | 58 / 303 | Day 2 | Denis Shapovalov | 12 | Win | 6–4, 6–0 |
| Laver Cup Boston, United States Laver Cup Hard, indoor 24 – 26 September 2021 | – | Day 3 | Diego Schwartzman | 15 | not played | N/A |
| Indian Wells Masters Indian Wells, United States ATP Tour Masters 1000 Hard, outdoor 4–17 October 2021 |
| Indian Wells Masters Indian Wells, United States ATP Tour Masters 1000 Hard, outdoor 4–17 October 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Indian Wells Masters Indian Wells, United States ATP Tour Masters 1000 Hard, outdoor 4–17 October 2021 | 59 / 304 | 2R | Mackenzie McDonald (WC) | 57 | Win | 6–4, 6–2 |
| Indian Wells Masters Indian Wells, United States ATP Tour Masters 1000 Hard, outdoor 4–17 October 2021 | 60 / 305 | 3R | Filip Krajinović (27) | 34 | Win | 6–2, 7–6$^{(7–1)}$ |
| Indian Wells Masters Indian Wells, United States ATP Tour Masters 1000 Hard, outdoor 4–17 October 2021 | 61 / 306 | 4R | Grigor Dimitrov (23) | 28 | Loss | 6–4, 4–6, 3–6 |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 | – | 1R | Bye | Bye | Bye | Bye |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 | 62 / 307 | 2R | Ilya Ivashka | 46 | Win | 7–5, 6–4 |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 | 63 / 308 | 3R | Sebastian Korda | 39 | Win | 4–6, 6–1, 6–3 |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 | 64 / 309 | QF | Hugo Gaston (Q) | 103 | Win | 7–6$^{(9–7)}$, 6–4 |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 | 65 / 310 | SF | Alexander Zverev (4) | 4 | Win | 6–2, 6–2 |
| Paris Masters Paris, France ATP Tour Masters 1000 Hard, indoor 1–7 November 2021 | 66 / 311 | F | Novak Djokovic (1) | 1 | Loss | 6–4, 3–6, 3–6 |
| ATP Finals Turin, Italy ATP Finals Hard, indoor 15–22 November 2021 |
| ATP Finals Turin, Italy ATP Finals Hard, indoor 15–22 November 2021 | 67 / 312 | RR | Hubert Hurkacz (7) | 9 | Win | 6–7$^{(5–7)}$, 6–3, 6–4 |
| ATP Finals Turin, Italy ATP Finals Hard, indoor 15–22 November 2021 | 68 / 313 | RR | Alexander Zverev (3) | 3 | Win | 6–0, 6–7$^{(3–7)}$, 7–6$^{(8–6)}$ |
| ATP Finals Turin, Italy ATP Finals Hard, indoor 15–22 November 2021 | 69 / 314 | RR | Jannik Sinner (9) | 11 | Win | 6–0, 6–7$^{(5–7)}$, 7–6$^{(10–8)}$ |
| ATP Finals Turin, Italy ATP Finals Hard, indoor 15–22 November 2021 | 70 / 315 | SF | Casper Ruud (8) | 8 | Win | 6–4, 6–2 |
| ATP Finals Turin, Italy ATP Finals Hard, indoor 15–22 November 2021 | 71 / 316 | F | Alexander Zverev (3) | 3 | Loss | 4–6, 4–6 |
| Davis Cup Finals Group stage Knockout stage Madrid, Spain Davis Cup Hard, indoor 25 November – 5 December 2021 |
| Davis Cup Finals Group stage Knockout stage Madrid, Spain Davis Cup Hard, indoor 25 November – 5 December 2021 | 72 / 317 | RR | Emilio Gómez | 149 | Win | 6–0, 6–2 |
| Davis Cup Finals Group stage Knockout stage Madrid, Spain Davis Cup Hard, indoor 25 November – 5 December 2021 | 73 / 318 | RR | Pablo Carreño Busta | 20 | Win | 6–2, 7–6$^{(7–3)}$ |
| Davis Cup Finals Group stage Knockout stage Madrid, Spain Davis Cup Hard, indoor 25 November – 5 December 2021 | 74 / 319 | QF | Mikael Ymer | 93 | Win | 6–4, 6–4 |
| Davis Cup Finals Group stage Knockout stage Madrid, Spain Davis Cup Hard, indoor 25 November – 5 December 2021 | 75 / 320 | SF | Jan-Lennard Struff | 51 | Win | 6–4, 6–4 |
| Davis Cup Finals Group stage Knockout stage Madrid, Spain Davis Cup Hard, indoor 25 November – 5 December 2021 | 76 / 321 | W | Marin Čilić | 30 | Win | 7–6$^{(9–7)}$, 6–2 |

### Doubles matches

| Tournament | Match | Round | Opponents (seed or key) | Ranks | Result | Score |
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 Partner: Marcelo Demoliner |
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 Partner: Marcelo Demoliner | 1 / 29 | 1R | Dan Evans / Neal Skupski | 52 / 19 | Win | 6–3, 7–6$^{(7–4)}$ |
| Madrid Open Madrid, Spain ATP Tour Masters 1000 Clay, outdoor 3–9 May 2021 Partner: Marcelo Demoliner | 2 / 30 | 2R | Wesley Koolhof / Łukasz Kubot (7) | 17 / 10 | Loss | 5–7, 7–6$^{(7–4)}$. [3–10] |
| Italian Open Rome, Italy ATP Tour Masters 1000 Clay, outdoor 9–16 May 2021 Partner: Marcelo Demoliner |
| Italian Open Rome, Italy ATP Tour Masters 1000 Clay, outdoor 9–16 May 2021 Partner: Marcelo Demoliner | 3 / 31 | 1R | Jamie Murray / Bruno Soares (6) | 23 / 8 | Win | 3–6, 7–6$^{(7–5)}$, [10–4] |
| Italian Open Rome, Italy ATP Tour Masters 1000 Clay, outdoor 9–16 May 2021 Partner: Marcelo Demoliner | 4 / 32 | 2R | Adrian Mannarino / Benoît Paire | 190 / 88 | Loss | 3–6, 6–7$^{(2–7)}$ |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 Partner: Aslan Karatsev |
| Summer Olympics Tokyo, Japan Olympic Games Hard, outdoor 24 July – 1 August 2024 Partner: Aslan Karatsev | 5 / 33 | 1R | Lukáš Klein / Filip Polášek | 263 / 11 | Loss | 5–7, 4–6 |

## Schedule
### Singles schedule

| Date | Tournament | Location | Tier | Surface | Prev. result | Prev. points | New points | Result |
| 1 February 2021– 7 February 2021 | ATP Cup | Melbourne (AUS) | ATP Cup | Hard | SF | 255 | 500 | Champion (defeated Italy, 2–0) |
| 8 February 2021– 21 February 2021 | Australian Open | Melbourne (AUS) | Grand Slam | Hard | R16 | 180 | 1200 | Final (lost to Novak Djokovic, 5–7, 2–6, 2–6) |
| 1 March 2021– 7 March 2021 | Rotterdam Open | Rotterdam (NED) | 500 series | Hard (i) | R32 | 0 | 0 | First round (lost to Dušan Lajović, 6–7$^{(4–7)}$, 4–6) |
| 8 March 2021– 14 March 2021 | Open 13 | Marseille (FRA) | 250 series | Hard (i) | QF | 45 | 250 | Champion (defeated Pierre-Hugues Herbert, 6–4, 6–7$^{(4–7)}$, 6–4) |
| 22 March 2021– 4 April 2021 | Miami Open | Miami (USA) | Masters 1000 | Hard | NH | 45 | 180 | Quarterfinals (lost to Roberto Bautista Agut, 4–6, 2–6) |
| 12 April 2021– 18 April 2021 | Monte Carlo Masters | Monte Carlo (MON) | Masters 1000 | Clay | SF | 180 | 0 (180) | Withdrew |
| 19 April 2021– 25 April 2021 | Barcelona Open | Barcelona (ESP) | 500 Series | Clay | F | 150 | 0 (150) | Withdrew |
| 3 May 2021– 9 May 2021 | Madrid Open | Madrid (ESP) | Masters 1000 | Clay | R64 | 5 | 90 | Third round (lost to Cristian Garín, 4–6, 7–6$^{(7–2)}$, 1–6) |
| 10 May 2021– 16 May 2021 | Italian Open | Rome (ITA) | Masters 1000 | Clay | R64 | 10 | 10 | Second round (lost to Aslan Karatsev, 2–6, 4–6) |
| 31 May 2021– 13 June 2021 | French Open | Paris (FRA) | Grand Slam | Clay | R128 | 5 | 360 | Quarterfinals (lost to Stefanos Tsitsipas, 3–6, 6–7$^{(3–7)}$, 5–7) |
| 14 June 2021– 20 June 2021 | Halle Open | Halle (GER) | 500 Series | Grass | N/A | N/A | 0 | First round (lost to Jan-Lennard Struff, 6–7$^{(6–8)}$, 3–6) |
| 14 June 2021– 20 June 2021 | Queen's Club | London (GBR) | 500 Series | Grass | SF | 90 | 0 (90) | Withdrew |
| 21 June 2021– 26 June 2021 | Mallorca Championships | Mallorca (ESP) | 250 Series | Grass | N/A | N/A | 250 | Champion (defeated Sam Querrey, 6–4, 6–2) |
| 28 June 2021– 11 July 2021 | Wimbledon | London (GBR) | Grand Slam | Grass | R32 | 45 | 180 | Fourth round (lost to Hubert Hurkacz, 6–2, 6–7$^{(2–7)}$, 6–3, 3–6, 3–6) |
| 24 July 2021– 1 August 2021 | Summer Olympics | Tokyo (JPN) | Olympic Games | Hard | NH | N/A | N/A | Quarterfinals (lost to Pablo Carreño Busta, 2–6, 6–7$^{(5–7)}$) |
| 31 July 2021– 8 August 2021 | Citi Open | Washington (USA) | 500 Series | Hard | F | 150 | 0 (150) | Withdrew |
| 9 August 2021– 15 August 2021 | Canadian Open | Toronto (CAN) | Masters 1000 | Hard | NH | 300 | 1000 | Champion (defeated Reilly Opelka, 6–4, 6–3) |
| 16 August 2021– 22 August 2021 | Cincinnati Masters | Cincinnati (USA) | Masters 1000 | Hard | QF | 180 | 360 | Semifinals (lost to Andrey Rublev, 6–2, 3–6, 3–6) |
| 30 August 2021– 12 September 2021 | US Open | New York (USA) | Grand Slam | Hard | SF | 720 | 2000 | Champion (defeated Novak Djokovic, 6–4, 6–4, 6–4) |
| 4 October 2021– 17 October 2021 | Indian Wells Masters | Indian Wells (USA) | Masters 1000 | Hard | NH | 23 | 90 | Fourth round (lost to Grigor Dimitrov, 6–4, 4–6, 3–6) |
| 1 November 2021– 7 November 2021 | Paris Masters | Paris (FRA) | Masters 1000 | Hard (i) | W | 1000 | 600 | Final (lost to Novak Djokovic, 6–4, 3–6, 3–6) |
| 15 November 2021– 21 November 2021 | ATP Finals | Turin (ITA) | ATP Finals | Hard (i) | W | 1500 | 1000 | Final (lost to Alexander Zverev, 4–6, 4–6) |
| 25 November 2021– 5 December 2021 | Davis Cup Finals Knockout stage | Madrid (ESP) | Davis Cup | Hard (i) | W | N/A | N/A | Winner ( Russia defeated Croatia, 2–0) |
| Total year-end points | Total year-end points | Total year-end points | Total year-end points | Total year-end points | Total year-end points | 8470 | 8640 | 170 difference |

## Yearly Records
### Earnings

* Bold font denotes tournament win
Singles :
| Event | Prize money | Year-to-date |
| ATP Cup | $576,725 | $8,276,287 |
| Australian Open | A$1,500,000 | $8,276,287 |
| Rotterdam Open | €13,800 | $8,276,287 |
| Open 13 | €52,500 | $8,276,287 |
| Miami Open | $61,000 | $8,276,287 |
| Madrid Open | €36,400 | $8,276,287 |
| Italian Open | €18,000 | $8,276,287 |
| French Open | €255,000 | $8,276,287 |
| Halle Open | €14,650 | $8,276,287 |
| Mallorca Championships | €70,620 | $8,276,287 |
| Wimbledon | £181,000 | $8,276,287 |
| Canadian Open | $370,290 | $8,276,287 |
| Cincinnati Masters | $285,000 | $8,276,287 |
| US Open | $2,500,000 | $8,276,287 |
| Indian Wells Masters | $92,000 | $8,276,287 |
| Paris Masters | €433,045 | $8,276,287 |
| ATP Finals | $1,222,000 | $8,276,287 |
| Bonus Pool | $810,000 | $8,276,287 |
| | | $8,276,287 |
| Doubles |||
| Event | Prize money | Year-to-date |
| Madrid Open | €6,905 | $14,987 |
| Italian Open | €5,500 | $14,987 |
| | | $14,987 |
| Total |||
| | | $8,291,274 |
Figures in United States dollars (USD) unless noted.
* source：2021 Singles Activity
* source：2021 Doubles Activity