# Hofmann–Löffler reaction

In organic chemistry, the Hofmann–Löffler reaction (also referred to as Hofmann–Löffler–Freytag reaction, Löffler–Freytag reaction, Löffler–Hofmann reaction, as well as Löffler's method) is a cyclization reaction with remote C–H functionalization. In the reaction, thermal or photochemical decomposition of N-halogenated amine 1 in the presence of a strong acid (concentrated sulfuric acid or concentrated CF$_3$CO$_2$H) generates a nitrogen radical intermediate. The radical then abstracts an intramolecular hydrogen atom to give a cyclic amine 2 (pyrrolidine or, in some cases, piperidine).

## History

In 1878, the structure of piperidine was still unknown, and A. W. Hofmann believed it unsaturated. Following standard analytical technique, Hofmann added hydrogen chloride or bromine to it in an attempt to induce hydrohalogenation. Instead, he produced N-haloamines and N-haloamides, whose reactions under acidic and basic conditions he investigated.
1‑bromo-2‑propyl­piperidine (3) and hot sulfuric acid, followed by basic work-up, formed a tertiary amine, later identified as δ-coneceine (4).
No further examples of the reaction were reported for about 25 years. But in 1909, K. Löffler and C. Freytag extended the transformation to simple secondary amines and applied the process in their elegant synthesis of nicotine (6) from N-bromo-N-methyl-4-(pyridin-3-yl)butan-1-amine (5).
The reaction mechanism only became clear around 1950, when S. Wawzonek investigated various N-haloamine cyclizations. Noting that the hydrogen peroxide or ultraviolet light greatly improved yields, Wawzonek and Thelan suggested a free-radical mechanism. E. J. Corey et al. then examined several features of the reaction: stereochemistry, hydrogen isotope effect, initiation, inhibition, catalysis, intermediates and selectivity of hydrogen transfer. The results, presented below, conclusively supported Wawzonek and Thelan's hypothesis.

## Reaction mechanism

According to Wawzonek and Thelan's 1949 proposal, an acid first protonates an N-chloroamine, which, in the presence of heat, light, or other initiators, homolyzes to ammonium and chloride free radicals. The ammonium radical intramolecularly abstracts a sterically favored hydrogen atom to afford an alkyl radical which, in a chain reaction, abstracts chlorine from another N-chloroammonium ion to form an alkyl chloride and a new ammonium radical. The alkyl chloride later cyclizes during the basic work-up to the cyclic tertiary amine.
Because the hydrogen abstraction is radical, any chiral configuration at the δ-carbon racemizes.
The reaction also has a quite large hydrogen isotope effect: in the decomposition of 10, the ratio of 1,2-dimethylpyrrolidine 11 and 1,2-dimethylpyrrolidine-2-d 12 (determined by combustion and IR spectra) suggests k$_H$⁄k$_D$ ≈ 3.42–3.54.
Comparable reactions at a primary carbon also give k$_H$⁄k$_D$≫1, which strongly suggests that the breaking of the C-H bond proceeds to a rather considerable extent in the transition state.

### Initiation, inhibition, catalysis

Molecular oxygen inhibits the reaction (trapping the radicals), but Fe$^{2+}$ salts initiate it.
Further investigations demonstrated that both the rate of the ultraviolet-catalyzed decomposition of dibutylchloroamine and the yield of newly formed pyrrolidine are strongly dependent on the acidity of the reaction medium – faster and higher-yielding reaction was observed with increasing sulfuric acid concentration.
An important question in discussing the role of the acid is whether the N-haloamine reacts in the free base or the salt form in the initiation step. Based on the pK$_a$ values of the conjugate acids of 2° alkyl amines (which are generally in the range 10–11), it is evident that N-chloroamines exist largely as salts in a solution of high sulfuric acid concentration. As a result, in the case of chemical or thermal initiation, it is reasonable to assume that it is the N-chloroammonium ion which affords the ammonium free radical. The situation changes, however, when the reaction is initiated upon irradiation with UV light. The radiation must be absorbed and the quantum of the incident light must be large enough to dissociate the N-Cl bond in order for a photochemical reaction to occur. Because the conjugate acids of the N-chloroamines have no appreciable UV absorption above 225 nm, whereas the free N-chloroamine absorb UV light of sufficient energy to cause dissociation (λ$_{max}$ 263 nm, ε$_{max}$ 300), E. J. Corey postulated that in this case it is actually the small percentage of free N-chloroamine that is responsible for most of the initiation. It was also suggested that the newly generated neutral nitrogen radical is immediately protonated. However, it is important to realize that an alternative scenario might be in operation when the reaction is initiated with the UV light; namely, the free N-haloamine might not undergo dissociation upon irradiation, but it might function as a photosensitizer instead. While it was proposed that the higher acid concentration decreases the rate of the initiation step, the acid catalysis involves acceleration of the propagation steps and/or retardation of the chain termination. The influence of certain acidic solvents on the photolytic Hofmann–Löffler–Freytag reaction was also studied by Neale and co-workers.

#### Intermediates

Isolation of 4-chlorodibutylamine from decomposition of dibutylchloroamine in H$_2$SO$_4$ confirmed the intermediacy of δ–chloroamines. When the acidic solution is made basic, the δ–chloroamine cyclizes to give a cyclic amine and a chloride ion.

#### Selectivity of hydrogen transfer

In order to determine the structural and geometrical factors affecting the intramolecular hydrogen atom transfer, a number of different N-chloroamines were examined in the Hofmann–Löffler–Freytag reaction. The systems were judiciously chosen in order to obtain data on the following points: relative migration tendencies of primary (1°), secondary (2°) and tertiary (3°) hydrogens; relative rates of 1,5- and 1,6-hydrogen rearrangements; and facility of hydrogen rearrangements in cyclic systems of restricted geometry.
Investigation of the free radical decomposition of N-chlorobutylamylamine 13 allowed to determine 1° vs. 2° hydrogen migration. It was reported that only 1-n-butyl-2-methylpyrrolidine 14 was formed under the reaction conditions, no 1-n-amylpyrrolidine 15 was detected. This observation provided substantial evidence that the radical attack exhibits strong preference for the 2° over 1° hydrogen.
Tendency for 3° vs. 1° hydrogen migration was studied with n-butylisohexylamine 16. When 16 was subjected to the standard reaction conditions, rapid disappearance of 16 was observed, but no pyrrolidine product could be isolated. This result suggested that there is a high selectivity for the 3° hydrogen, but the intermediate tertiary chloro compound 17 is rapidly solvolyzed.
Similarly, no cyclic amine was observed with the reaction of n-amylisohexylamine, which demonstrates the selectivity for the 3° vs. 2° hydrogen migration.
A qualitative study of products from the Hofmann–Löffler–Freytag reaction of N-chloromethyl-n-hexylamine 18 was performed in order to evaluate the relative ease of 1,5- and 1,6-hydrogen migration. UV-catalyzed decomposition of 18 followed by basification produced a 9:1 mixture of 1-methyl-2-ethylpyrrolidine 19 and 1,2-dimethylpiperidine 20, which demonstrates that the extent of formation of six-membered rings can be appreciable.
In terms of the geometrical requirements in the intramolecular rearrangement of hydrogen, it was observed that under identical reaction conditions the UV light-catalyzed decomposition of methylcyclohexylchloroamine and N-chloroazacycloheptane proceeds far more slowly than that of dibutylchloroamine. These findings indicate that the prevailing geometries are in these two cases unfavourable for the rearrangement to occur and the Cδ–H–N bond angle required for the intramolecular hydrogen transfer cannot be easily attained.

### Generally accepted mechanism

It is generally accepted that the first step in the Hofmann–Löffler–Freytag reaction conducted in acidic medium is the protonation of the N-halogenated amine 21 to form the corresponding N-halogenated ammonium salt 22. In case of thermal or chemical initiation of the free radical chain reaction, the N-halogenated ammonium salt 22 undergoes homolytic cleavage of the nitrogen-halogen bond to generate the nitrogen-centered radical cation 23. In contrast, it has been argued that the UV light-catalyzed initiation involves the free form of the N-haloamine and a rapid protonation of the newly generated neutral nitrogen radical (see the section devoted to mechanistic studies for arguments supporting this statement). Intramolecular 1,5-hydrogen atom transfer produces carbon-centered radical 24, which subsequently abstracts a halogen atom from the N-halogenated ammonium salt 22. This affords the protonated δ-halogenated amine 25 and regenerates the nitrogen-centered radical cation 23, the chain carrier of the reaction. Upon treatment with base, 25 undergoes deprotonation followed by an intramolecular S$_N$2 reaction to yield pyrrolidine 28 via intermediate 27.
The preferential abstraction of the δ–hydrogen atom corresponds to a six-membered transition state, which can adopt the unstrained cyclohexane chair-type conformation 29.
The Hofmann–Löffler–Freytag reaction is conceptually related to the well-known Barton reaction.

## General features of the reaction

* The starting material for the Hofmann–Löffler–Freytag reaction could be N-chloro-, N-bromo-, and N-iodoamines. In case of thermal initiation, the N-chloroamines give better yields for pyrrolidines because N-bromoamines are less stable thermally than the corresponding N-chloroamines. In contrast, when the initiation is carried out by irradiation, the N-bromoamines give higher yield for pyrrolidines.
* The Hofmann–Löffler–Freytag reaction was originally carried out under acidic conditions, but it has been demonstrated that neutral or even weakly basic conditions might also be successfully employed.
* The initially formed nitrogen-centered radical abstracts a H-atom mostly from the δ-position and thus 5-membered rings are formed predominantly.
* Formation of 6-membered rings is also possible, but relatively rare, and in majority of cases is observed in rigid cyclic systems.
* The reaction can be conducted under milder conditions provided that the alkyl radical experiences some form of extra stabilization, e.g. by an adjacent heteroatom.
* The radical process may be initiated by heating, irradiation with light or with radical initiators (e.g. peroxides, metal salts).

## Modifications and improvements

Because the original strongly acidic reaction conditions are often not compatible with the sensitive functional and protecting groups of complex substrates, several modifications of the Hofmann–Löffler–Freytag reaction were introduced:
* M. Kimura and Y. Ban demonstrated that adjacent nitrogen atoms can stabilize radical species generated by H-atom abstraction and permit this step to take place under weakly basic conditions They reported that far better yields are obtained on photoirradiation in the presence of triethylamine, which neutralizes the hydrogen chloride generated by cyclization. M. Kimura and Y. Ban employed the modified conditions of the Hofmann–Löffler–Freytag reaction to the synthesis of dihydrodeoxyepiallocernuine 35.
* It has been demonstrated that photolysis of N-haloamides proceeds efficiently under neutral conditions. Irradiation of N-bromoamide 36 (R=$^t$Bu) gave rise to bromomethyl-cyclohexane-amide 37 which, upon treatment with base in situ afforded iminolactone 38 in 92% yield.
Similarly, S. W. Baldwin and T. J. Doll examined a modification of the Hofmann–Löffler–Freytag reaction during their studies towards the synthesis of the alkaloid gelsemicine 41. The formation of the pyrrolidine ring of 40 was accomplished by irradiation of N-chloroamide 39.
* Another variation of the Hofmann–Löffler–Freytag reaction involves sulfonamides in place of N-haloamines. In the presence of persulphates and metal salts, sulfonamides can undergo intramolecular free-radical funcionalization to produce γ- and δ-chloroalkenylsulfonamides under neutral conditions. For instance, upon treatment with Na$_2$S$_2$O$_8$ and CuCl$_2$, butylsulfonamide 42 was transformed to 4-chlorobutylsulfonamide 43 and 3- chlorobutylsulfonamide 44 in the absence of acid.
* The most important variation of the Hofmann–Löffler–Freytag reaction is the Suárez modification. In 1980, Suárez et al. reported a process using neutral conditions for the Hofmann–Löffler–Freytag reaction of N-nitroamides. Further developments of this transformation have led to the expansion of the substrate scope to N-cyanamides, N-phosphoramidates and carbamates. All these species react with hypervalent iodine reagents in the presence of iodine (I$_2$) to generate nitrogen-centered radical via homolytic fragmentation of a hypothetical iodoamide intermediate. Thus formed N-radicals might participate in an intramolecular 1,5-hydrogen abstraction reaction from unactivated carbons, the result being the formation of pyrrolidines.
The great advantage of the Suárez modification is that the reaction can be performed under very mild neutral conditions compatible with the stability of the protective groups most frequently used in synthetic organic chemistry. Consequently, it permits the use of the Hofmann–Löffler–Freytag reaction with more sensitive molecules. Other notable features of this methodology are the following: (1) the unstable iodoamide intermediates are generated in situ; (2) the iodoamide homolysis proceeds thermally at low temperature (20–40 °C) or by irradiation with visible light, which obviates the need for a UV lamp. The Suárez modification has found numerous applications in synthesis (vide infra).
* Nagib and co-workers have employed a triiodide strategy that expands the scope of the Hofmann–Löffler–Freytag reaction via the Suárez modification to enable the amination of secondary C-H bonds. This approach employs NaI, instead of I$_2$, as a radical precursor to prevent undesired I$_2$-mediated decomposition pathways. Other halide salts (e.g. NaCl and NaBr) afford the postulated intermediates of the interrupted Hofmann–Löffler–Freytag mechanism.

## Applications in synthesis

The most prevalent synthetic utility of the Hofmann–Löffler–Freytag reaction is the assembly of the pyrrolidine ring.

### The Hofmann–Löffler–Freytag reaction under standard conditions

The procedure for the Hofmann–Löffler–Freytag reaction traditionally requires strongly acidic conditions, which limits its appeal. Nonetheless, it has been successfully applied to functionalization of a wide variety of structurally diverse molecules as exemplified below.
In 1980, J. P. Lavergne. et al. used this methodology to prepare L-proline 49.
P. E. Sonnet and J. E. Oliver employed classic Hofmann–Löffler–Freytag reaction conditions in the synthesis of potential ant sex pheromone precursors (i.e. octahydroindolizine 51).
Another example of the construction of a bicyclic amine through the standard Hofmann–Löffler–Freytag methodology is the Waegell's synthesis of azabicyclo[3.2.1]octane derivative 53.
The Hofmann–Löffler–Freytag reaction was employed to synthesize the bridged nitrogen structure of (±)-6,15,16-iminopodocarpane-8,11,13-triene 55, an intermediate useful for the preparation of the kobusine-type alkaloids, from a bicyclic chloroamine 54. Irradiation of 54 with a 400 W high-pressure mercury lamp in trifluoroacetic acid under a nitrogen atmosphere at room temperature for 5 h afforded a moderate yield of the product.
Derivatives of adamantane have also been prepared using the Hofmann–Löffler–Freytag reaction. When N-chloroamine 56 was treated with sulfuric acid and heat, 2-adamantanone was formed, but photolysis of 56 in the sulfuric acid-acetic acid mixture, using a low-pressure mercury lamp at 25 °C for 1-hour gave a good yield (85%) of the desired product 57. The cyclization of 57 presented considerable difficulties, but it was finally achieved in 34% yield under forcing conditions (heating at 290 °C for 10 min).
Similarly, it has been demonstrated that derivatives of diaza-2,6 adamantane such as 60 might be formed under standard Hofmann–Löffler–Freytag reaction conditions; however, the yields are only moderate.
R. P. Deshpande and U. R. Nayak reported that the Hofmann–Löffler–Freytag reaction is applicable to the synthesis of pyrrolidines containing a longifolene nucleus, e.g. 62.
An outstanding application of the Hofmann–Löffler–Freytag reaction is found in the preparation of the steroidal alkaloid derivatives. J. Hora and G. van de Woude used this procedure in their syntheses of conessine derivatives shown below.
In case of 64 and 66, the five-membered nitrogen ring is formed by attack on the unactivated C-18 methyl group of the precursor (63 or 65, respectively) by a suitably placed nitrogen-centered radical at C-20. The ease of this reaction is due to the fact that in the rigid steroid framework the β-C-18 methyl group and the β-C-20 side chain carrying the nitrogen radical are suitably arranged in space in order to allow the 1,5-hydrogen abstraction to proceed via the six-membered transition state.

### The Hofmann–Löffler–Freytag reaction under mild conditions

A number of examples of the Hofmann–Löffler–Freytag reaction under neutral conditions have been presented in the section devoted to modifications and improvements of the original reaction conditions. Hence, the main focus of this section are the applications of the Suárez modification of the Hofmann–Löffler–Freytag reaction.
The Suárez modification of the Hofmann–Löffler–Freytag reaction was the basis of the new synthetic method developed by H. Togo et al. The authors demonstrated that various N-alkylsaccharins (N-alkyl-1,2-benzisothiazoline-3-one-1,1,-dioxides) 77 are easily prepared in moderate to good yields by the reaction of N-alkyl(o-methyl)arenesulfonamides 70 with PhI(OAc)$_2$ in the presence of iodine under the irradiation of a tungsten lamp. 1,5 -Hydrogen abstraction/iodination of the o-methyl group is repeated three times and is most likely followed by cyclization to diiodo intermediate 76, which then undergoes hydrolysis.
A very interesting transformation is observed when sulfonamides of primary amides bearing an aromatic ring at the γ-position are treated with various iodanes and iodine under the irradiation with a tungsten lamp. The reaction leads to 1,2,3,4-tetrahydroquinoline derivatives and is a good preparative method of six-membered cyclic aromatic amines. For instance, sulfonamide 78 undergoes an intramolecular radical cyclization to afford 79 in relatively good yield.
By the same procedure, 3,4-dihydro-2,1-benzothiazine-2,2-dioxides 81 are obtained from the N-alkyl 2-(aryl)ethanesulfonamides via the sulfonamidyl radical.
E. Suárez et al. reported that the amidyl radical intermediates, produced by photolysis of medium-sized lactams, e.g. 82 in the presence of PhI(OAc)$_2$ and iodine, undergo transannular hydrogen abstraction to afford intramolecularly funcionalized compounds such as oxoindolizidines 83.
E. Suárez and co-workers also applied their methodology in the synthesis of chiral 8-oxa-6-azabicyclo[3.2.1]-octane 85 and 7-oxa-2-azabicyclo[2.2.1]heptane 87 ring systems. This reaction can be considered to be an intramolecular N-glycosidation that goes through an intramolecular 1,5-hydrogen abstraction promoted by an N-amido radical followed by oxidation of the transient C-radical intermediate to an oxycarbenium ion, which is subsequently trapped by an internal nucleophile.
The utility of the Suárez modification of the Hofmann–Löffler–Freytag reaction was demonstrated by its application in synthesis of a number of steroid and triterpene compounds. As illustrated below, the phosphoramidate-initiated funcionalizations generally proceed in higher yields than the reactions involving N-nitro or N-cyanamides.
In 2008 P.S. Baran et al. reported a new method for the synthesis of 1,3-diols using a variant of the Hofmann–Löffler–Freytag reaction.
In 2017, Nagib et al. reported a new method for the synthesis of 1,2-amino-alcohols using a variant of the Hofmann–Löffler–Freytag reaction to promote β selective C-H amination of alcohols. In 2020, an asymmetric variant was disclosed by the same team.