OpenLLM-France/wikimedia huggingface dataset:
# Nirogacestat

Nirogacestat, sold under the brand name Ogsiveo, is an anti-cancer medication used for the treatment of desmoid tumors. It is a selective gamma secretase inhibitor that is taken by mouth.
The most common side effects include diarrhea, ovarian toxicity, rash, nausea, fatigue, stomatitis, headache, abdominal pain, cough, alopecia, upper respiratory tract infection and dyspnea.
Nirogacestat was approved for medical use in the United States in November 2023. It is the first medication approved by the US Food and Drug Administration (FDA) for the treatment of desmoid tumors. The FDA considers it to be a first-in-class medication.

## Medical uses

Nirogacestat is indicated for adults with progressing desmoid tumors who require systemic treatment.

## History

The effectiveness of nirogacestat was evaluated in DeFi (NCT03785964), an international, multicenter, randomized (1:1), double-blind, placebo-controlled trial in 142 adult participants with progressing desmoid tumors not amenable to surgery. Participants were randomized to receive 150 milligrams (mg) of nirogacestat or placebo orally, twice daily, until disease progression or unacceptable toxicity. The main efficacy outcome measure was progression-free survival (the length of time after the start of treatment for which a person is alive and their cancer does not grow or spread). Objective response rate (a measure of tumor shrinkage) was an additional efficacy outcome measure. The pivotal clinical trial demonstrated that nirogacestat provided clinically meaningful and statistically significant improvement in progression-free survival compared to placebo. Additionally, the objective response rate was also statistically different between the two arms with a response rate of 41% in the nirogacestat arm and 8% in the placebo arm. The progression-free survival results were also supported by an assessment of patient-reported pain favoring the nirogacestat arm.
As of 2021, nirogacestat was in phase II clinical trials for unresectable desmoid tumors. In addition, a phase III clinical trial, DeFi, was in progress for nirogacestat for adults with desmoid tumors and aggressive fibromatosis. In addition, three trials were recruiting patients that include nirogacestat with other anticancer therapies in multiple myeloma, including the UNIVERSAL study for nirogacestat with the allogeneic CAR-T therapy ALLO-715.
The FDA granted the application for nirogacestat priority review, fast track, breakthrough therapy, and orphan drug designations. The FDA granted the approval of Ogsiveo to SpringWorks Therapeutics Inc.

## Society and culture
### Legal status

Nirogacestat was granted breakthrough therapy designation by the FDA in September 2019, for adults with progressive, unresectable, recurrent or refractory desmoid tumors or deep fibromatosis.
# Blaise Garza

Blaise Garrett Garza (born February 10, 1989) is an American actor and musician.

## Acting career

From 1994 to 1996, Garza played the role of Gregory Hudson, the son of John (David Forsyth) and Sharlene Hudson (Anna Kathryn Holbrook), on Another World. Garza's hiring was the first audition he had ever been on. He later appeared in various television commercials and was the poster child for White House Juice, appearing as "Jimmy Juice". After various commercials and industrials, Blaise was cast in his first feature film, Yukie (aka Solitude Point), in 1998, playing the grandson of Bo Svenson and Mitsuko Baisho. Blaise appeared in several more commercials before he was cast in his next feature film, All Over the Guy (2001), where he played a young Tom (Richard Ruccolo), and later in Drillbit Taylor (2008).

## Music education and career

Garza completed an interdisciplinary undergraduate music degree at UCSD in 2011. Upon graduation, he collaborated with the Museum of Making Music—a division of the NAMM Foundation—on its exhibition "The Sound of Sax: How the Saxophone Won America's Soul". The exhibit featured rare and historical saxophones from the collections of Garza and Rob Verdi and ran until January 2013.
Garza's album Low Standards was released in 2012 to accompany the saxophone exhibit and features the E♭ and B♭ tubax and contrabass saxophone. He also performed with the Green and Rebelution on their "Peace of Mind" tour in 2012 and played saxophone on Sly Stone's 2014 singles "One More Hit" and "Role Model".
Garza has been performing with Violent Femmes since 2004 and is featured on their 2015 EP Happy New Year, on bass saxophone and piano, as well as the albums We Can Do Anything (2016), playing contrabass, bass and baritone saxophone, and 2 Mics & the Truth: Unplugged and Unhinged in America (2019), on baritone sax, cabasa and vocals.
While touring with the Violent Femmes as part of the Barenaked Ladies' 2015 "Last Summer On Earth" tour, Garza joined Barenaked Ladies and former Men at Work frontman Colin Hay (who was also part of the tour) in performing "Who Can It Be Now?" every night. One of these performances is featured on the live album BNL Rocks Red Rocks (2016).
Garza also formed trip-hop group Yulan & Blaise with actress Yulan Jack in 2024. Their first single, God Complex, was released on November 22, 2024, alongside a music video. The project will release an EP in 2025.

## Filmography

* Another World (1994–1996)
* Solitude Point (1998)
* All Over the Guy (2001)
* Drillbit Taylor (2008)

## Discography

* 2004 – "Genesis Concert" (with Adam Gilberti and the Central Coast Philharmonia)
* 2012 – "Low Standards"
* 2014 – "One More Hit" (single) (with Sly Stone)
* 2014 – "Role Model" (single) (with Sly Stone)
* 2015 – "Happy New Year" (with Violent Femmes)
* 2016 – "We Can Do Anything" (with Violent Femmes)
* 2016 – "BNL Rocks Red Rocks" (with Barenaked Ladies)
* 2017 – "2 Mics & the Truth: Unplugged and Unhinged in America" (with Violent Femmes)
* 2019 – "Hotel Last Resort" (with Violent Femmes)
* 2024 – "God Complex" (single) (with Yulan & Blaise)
# Feltia repleta

The replete dart (Feltia repleta) is a moth of the family Noctuidae. It is a tropical species found from Argentina and Brazil to Mexico and occurs occasionally in Florida, Louisiana and southern Texas.
The wingspan is 45–50 mm.
The larvae feed on a wide variety of plants, including various agricultural crops such as tomatoes.
# Ilha das Flores

Ilha das Flores is a municipality in the state of Sergipe (SE) in Brazil. The population is 8,521 (2020 est.) in an area of 54.64 km$^2$ (21.10 sq mi). The elevation is 3 m (9.8 ft).
# Piaggio Quargo

The Piaggio Quargo is a commercial vehicle produced by Piaggio from 2004 to 2016 and part of the category of heavy quadricycles, designed to replace the Ape Poker.

## Context

Made on the same base as the Piaggio Porter, from which it takes up the mechanical layout and part of the bodywork like the doors, the Quargo is equipped with a transverse, rear mounted diesel engine 686 twin cm$^3$ Lombardini from 13 kW (about 18 hp).
It consists of a light quadricycle that requires the driving license B1 to be driven (it could also be driven by those who have the previous A1 and category A sub-licenses, if obtained by January 18, 2013) available in versions pick-up, tipper pick-up, van and curtainseat, with payload up to 750 kg depending on version. In 2007, the updated version was presented, with disc brakes on the front wheels and oversized oil sump.
Production ended at the end of 2016 as, with the entry into force of the anti-pollution regulations Euro 4 for quadricycles, the Quargo was not adjusted.
# Laga Xafo Laga Dadhi

Laga Xafo Laga Dadhi (Oromo: laga Xaafoo Laga Daadhii) is a city adjacent to Addis Ababa located in the Oromia Special Zone Surrounding Finfinne. It was created in 2008 from North Shewa Zone (Oromia)
# Darinaparsin

Darinaparsin (trade names Darvias and Zinapar) is a drug for the treatment of various types of cancer. It is an arsenic-containing derivative of glutathione.
The mechanism of action of darinaparsin is proposed to involve disruption of mitochondrial function, increased production of reactive oxygen species, and modulation of intracellular signal transduction pathways, thereby inducing cell cycle arrest and apoptosis in cancer cells.

## History

Darinaparsin and related compounds were first studied in the 1970s at Texas A&M University. It wasn't until 1998, when a connection between organoarsenic compounds and their potential use in cancer chemotherapy was reported, that interest in darinaparsin as a pharmaceutical drug began. Darinaparsin was licensed to Ziopharm Oncology and then Solasia Pharma for drug development. In 2018, Solasia Pharma licensed Darinaparsin to HB Human BioScience SAS of Bogota Colombia. HB Human BioScience SAS began the registration process in Colombia, Peru, Ecuador, Venezuela, Chile, Panama, Costa Rica, and Guatemala, while offering Darinaparsin on a compassionate use (expanded access) basis.
Darinaparsin was granted Orphan Drug Designation in the US and Europe as a treatment for peripheral T-cell lymphoma (PTCL).
In Japan, darinaparsin was approved for relapsed or refractory PTCL in June 2022.
Darinaparsin was submitted for INVIMA Approval in Colombia on December 12, 2023
# Keyvan Vahdani

Keyvan Vahdani (Persian: کیوان وحدانی; 1 April 1991 – 20 March 2019) was an Iranian footballer. He played for Paykan, Nassaji and Pars Jonoubi.
He died in a landslide in Mazandaran province, Iran, on 20 March 2019 at the age of 27.
# St. Thomas College, Palai

St. Thomas College, Pala (Autonomous) is a government aided college of higher education located in Pala town, Kerala, India. It was founded on 7 August 1950 by the Syro-Malabar Catholic Eparchy of Palai. The college is affiliated to Mahatma Gandhi University Kottayam and was re-accredited with A++ grade by NAAC in February 2021. The college is recognized under the sections 2(f) and 12B of the UGC Act 1956. The Government of Kerala has recognized the college as a Special Grade College.

## History

Founded in 1950. The main block, "Tisserant Hall", called A-block, stoutly built with an enormous roof span and massive columns was ready to house the administration, classrooms, laboratories and libraries in 1953. The first Prime Minister of India Pandit Jawaharlal Nehru visited the college in 1954. In 1981, Rt. Rev. Dr. Joseph Pallickaparambil took over as the Bishop of Palai and the patron of St. Thomas College. In 2005 H.E. Bishop Mar Joseph Kallarangattu became the Bishop of Palai and the Patron of the college. The college celebrated its Silver Jubilee in 1976 with Prime Minister Mrs. Indira Gandhi as the chief guest. The preceding decade had been one of hectic academic activity during which more Post graduate courses- English, Physics, Economics and Mathematics were started, new hostels inaugurated, more blocks added to the cluster of buildings in the campus etc. Rev. Dr. N.M. Thomas, who succeeded Fr. Joseph Kureethadam as principal in 1968, retired from service in the jubilee year passing the baton to Prof. P.M. Chacko. Fr. James Vellankal followed Prof. Chacko in 1984. The successors of Fr. Vellankal included an illustrious line of academic administrators combining erudition with sharp acumen - Fr. Enas Ottathengumkal (1986-1991), Fr. Philip Njaralakkattu (1991-1995), Rev. Dr. Kurian Mattam (1995-2001) and Rev. Dr. M.M. Mathew Maleparambil (2001–06). During 2006-09 Rev. Dr. Mathew John K was officiated as the drawing and disbursement officer.

## Accreditation

The National Assessment and Accreditation Council (NAAC) has awarded A++ Grade to St.Thomas' College with CGPA score 3.56. Furthermore, UGC has recognised St. Thomas College as one among the six colleges in Kerala accorded with the status of 'College with Potential for Excellence'(CPE).

## Notable alumni

* V. Joseph Thomas - IPS, ex-DGP of Kerala
* Anto Antony - Member of parliament
* Don Max - film director and editor
* Jimmy George - Volleyball player
* Roshy Augustine - Minister for Water Resources, Government of Kerala
* Sibi George - civil servant, ambassador of India to Kuwait
* Paul Zacharia - Writer
* Miya George - Actress
* Jose Chacko Periappuram - Cardiac Surgeon
# Khalid bin Mohsen Shaari

Khalid bin Mohsen Shaari (Arabic: خالد بن محسن الشاعري; born 28 February 1991) is a Saudi Arabian man, who in August 2013 was found to be the heaviest living person, and the second-heaviest person in recorded history at 610 kg (1,340 lb; 96 st), behind Jon Brower Minnoch. As a result of medical treatment, he lost a total of 320 kg (710 lb; 50 st)—more than half his body weight—in six months.

## Early life

Khalid bin Mohsen Shaari was born in Saudi Arabia on 28 February 1991. He was 22 when he was declared the "fattest man alive" in 2013, with a BMI of 204.

## Weight loss

In August 2013, Saudi King Abdullah ordered him to come from his home in Jizan to King Fahd Medical City in the country's capital, Riyadh, to undergo a series of dietary and physical programs to help him lose weight. In February 2016, due to the weight loss treatment, he was able to walk for the first time in five years, with the help of a walker. By November 2017, he had lost 542 kg (1,195 lb; 85.4 st) and now weighs 68 kg (150 lb; 10.7 st). In January 2018 he had the last of a series of surgeries to remove excess skin that accumulated due to his weight loss.
# James Philbrook

James Philbrook was an American actor who appeared in several major films, including I Want to Live! (1958), Woman Obsessed and as Colonel Tall in the 1964 war picture The Thin Red Line. He had supporting roles on television, including The Islanders (1960–61) and The New Loretta Young Show (1962 - 1963).

## Early years

Philbrook was born on October 22, 1924, at Davenport, Iowa, the son of Roland F. Philbrook, a clergyman. He attended St. Ambrose University and the University of Iowa, eventually completing an electrical engineering degree from the Massachusetts Institute of Technology in 1946.
A December 26, 1962, newspaper article reported on Philbrook's varied occupational experiences: "At various times, he's been a miner, a rodeo performer, a gym instructor, a writer, a photographer — you name, he's done it with various degrees of success."

## Military service

Philbrook was an aviation electronics specialist for the Navy for four years during the Korean War. He was stationed in Africa, the Aleutian Islands, China, Europe, and India.

## Personal life

Philbrook was married to the former Frances Cassling. They had four children.

## Death

Philbrook died on October 24, 1982, at Los Angeles, California.

## Filmography

| Year | Title | Role | Notes |
| 1957 | Alfred Hitchcock Presents | Horse Mover | Season 2 Episode 35: "The West Warlock Time Capsule" |
| 1958 | From Hell to Texas | Bartender | Uncredited |
| 1958 | In Love and War | Sue's Boyfriend | Uncredited |
| 1958 | I Want to Live! | Bruce King | |
| 1959 | Warlock | Cade | Uncredited |
| 1959 | Perry Mason | Harry Jonson | Season 2 Episode 30 "The Case of the Lame Canary" |
| 1959 | Woman Obsessed | Henri | |
| 1962 | The Wild Westerners | Marshal Jim McDowell | |
| 1964 | The Thin Red Line | Colonel Tall | |
| 1965 | Finger on the Trigger | Adam Hyde | |
| 1965 | Son of a Gunfighter | James 'Ace' Ketchum | |
| 1966 | Sound of Horror | Dr. Pete Asilov | |
| 1966 | The Drums of Tabu | Bill Harrigan | |
| 1966 | El arte de casarse | Colonel W. P. Morgan | (segment "Profesor de matrimonio") |
| 1966 | Two Thousand Dollars for Coyote | Sam Foster | |
| 1967 | Los 7 de Pancho Villa | Sheriff of Cerezo | |
| 1968 | Ballad of a Bounty Hunter | Don Ramon | |
| 1969 | La muchacha del Nilo | James | |
| 1970 | El último día de la guerra | Lieutenant Poole | |
| 1975 | The Killer is Not Alone | Don Enrique Nieto | |
| 1975 | Si quieres vivir… dispara | Sam | (final film role) |
# Trimmed in Scarlet

Trimmed in Scarlet is a 1923 American silent drama film directed by Jack Conway and produced and distributed by Universal Pictures. It is based on the 1920 Broadway play, Trimmed in Scarlet, by William Hurlbut and starring Broadway's Maxine Elliott. This play marked the last time Maxine Elliott appeared on Broadway. Her role in the film is played by veteran cinema star Kathlyn Williams. All prints of this film are believed lost.

## Cast

* Kathlyn Williams as Cordelia Ebbing / Madame de la Fleur
* Roy Stewart as Revere Wayne
* Lucille Ricksen as Faith Ebbing (credited as Lucille Rickson)
* Robert Agnew as David Pierce
* David Torrence as Charles Knight
* Phillips Smalley as Peter Ebbing
* Eve Southern as Fifi Barclay
* Bert Sprotte as Duroc
* Grace Carlyle as Molly Todd
* Gerard Alexander as Ruth Kipp (credited as Gerard Grassby)
* Raymond Hatton as Mr. Kipp
* Philo McCullough as Count De Signeur
# Target (2004 film)

Target is a 2004 action film directed by William Webb and starring Stephen Baldwin.

## Plot

Charlie Snow (Stephen Baldwin) was a highly decorated war hero, a sniper who never placed emotion before the mission. Except once. Providing cover for an undercover arms dealer sting operation, he was forced into a predicament, as through his scope he saw a hostage crisis unfold.
The decision he made cost his fellow soldiers their lives. But he also managed to kill the hostage-taker, arms dealer Lendl Bodnar (Mio Deckala).
Back in the US, Charlie is now a shell of the man he used to be. He has been ostracized from the government, and his family is falling apart. His wife Maggie (Deborah Worthing) is close to finalizing their split.
But Charlie's world is about to get rocked. Lendl Bodnar has a brother named Yevon Bodnar (Yorgo Constantine), an arms dealer who wants revenge on Charlie for Lendl's death.
Charlie's learns that Maggie has been kidnapped, his daughter Lisa (Steffani Brass) and son Sam (Rory Thost) are in danger. Everywhere he turns, he's being attacked by Yevon's men.
Charlie must summon all the tactics that made him such an effective killer and reconnect with his secret ops government links to rescue Maggie and take Yevon down.

## Cast

* Stephen Baldwin - Charlie Snow
* James Russo - Donovan
* Steffani Brass - Lisa Snow (as Stephanie Brass)
* Yorgo Constantine - Yevon Bodnar
* Deborah Worthing - Maggie
* Patty McCormack - Maysie
* Rory Thost - Sam Snow
* Tammy Trull - Sunny
* Debra Wilson - Nolan
* Kenya D. Williamson - Miss Demmings
* Igor Jijikine - Leather Jacket
# Artwork (disambiguation)

An artwork, or work of art, is an aesthetic item or artistic creation.
Artwork or Artworks may also refer to:

## Arts and entertainment

* Artwork (album), by The Used, 2009
* Artwork (musician), a member of Magnetic Man
* Artworks (album), by Art Pepper, 1984
* Artworks (film), a 2003 crime film

## Other uses

* Artwork (graphic arts), a graphical representation of an image used in the printing process
* ArtWorks, a software package
# Range War

Range War is a 1939 American Western film directed by Lesley Selander and written by Sam Robins and Walter C. Roberts. The film stars William Boyd, Russell Hayden, Britt Wood, Pedro de Cordoba, Willard Robertson, Matt Moore and Betty Moran. The film was released on September 8, 1939, by Paramount Pictures.

## Plot

Buck Colins heads a group of local ranchers who are trying to prevent the railroad from completing its line through their property. Till now they have been able to charge tolls on herds passing through. Hoppy goes undercover to expose them.

## Cast

* William Boyd as Hopalong Cassidy
* Russell Hayden as Lucky Jenkins
* Britt Wood as Speedy MacGinnis
* Pedro de Cordoba as Padre Jose
* Willard Robertson as Buck Collins
* Matt Moore as Jim Marlow
* Betty Moran as Ellen Marlow
* Kenneth Harlan as Charles Higgins
* Francis McDonald as Dave Morgan
* Eddie Dean as Henchman Pete
* Earle Hodgins as Deputy Sheriff
* Jason Robards, Sr. as Rancher
* Stanley Price as Agitator
* Ray Bennett as Henchman Stokey
# François-Hippolyte Barthélémon

François Hippolyte Barthélemon (27 July 1741 – 20 July 1808) was a French violinist, pedagogue, and composer active in England.

## Biography

François Barthélemon was born in Bordeaux (Gironde), France. He received his education in Paris, where he studied musical composition and violin, and performed in the orchestra of the Comédie-Italienne. In 1764, he traveled to England to lead a band at the King's Theatre and at Marylebone Gardens where he was received with enthusiasm. This led to a commission for his first dramatic stage work, Pelopida, an opera in three acts in the Italian style that was performed at the King's Theatre in 1766. David Garrick of the Drury Lane Theatre engaged him to compose music to Garrick's two-act farcical burletta based on the Orpheus myth, which premiered in 1768. In the same year, Barthélemon also premiered Oithona, a three-act dramatic operatic poem; La fleuve Scamandre ("The Scamander River"), a French-style comic opera based on a Greek myth; and The Judgment of Paris, another two-act burletta. Further engagements led him to decide to stay in England, where he wed soprano and composer Polly Young in December 1766 and raised a family. He is well known for his tune 'Morning Hymn' to Thomas Ken's hymn 'Awake my soul, and with the sun...', which Thomas Hardy praised in his Barthélemon at Vauxhall. He also wrote the tune of the hymn, Mighty God While Angels Bless Thee.
Barthélemon's dashing French style of composition allowed him to produce musical entertainments in a wide range of styles. He composed salon music and chamber music, as well as volumes of popular songs, some of which were published in London in 1790. The King's Theatre engaged him to write ballet music. Barthélemon also composed scenes for humorous English ballad operas and for masques. The Maid of Oaks, a masque within a comedy in five acts based on Sylvain by Jean-François Marmontel, enjoyed much success in 1774. He also wrote six symphonies, and some concertos.
As a private teacher, Bartélemon received approval for his "scientific" technique of violin playing; however, some popular critics felt his musical compositions lacked "a clearly developed personal style."
Barthélemon died at Christ Church, Surrey, England, aged 66.

## Selected works

* Pelopida, opera in 3 acts (1766)
* Orpheus, burletta in 2 acts (1767)
* Oithona, dramatic poem in 3 acts (1768)
* The Judgment of Paris, burletta in 2 acts (1768)
* Le fleuve Scamandre, comic opera (1768)
* The Magic Girdle, burletta in 2 parts (1770)
* The Noble Pedlar, or The Fortune Hunter, burletta in 2 parts (1770)
* The Portrait, burletta in 2 parts (ca. 1771)
* The Wedding Day, burletta in 2 parts (1773)
* La zingara, or The Gypsy, burletta in 2 parts (1773)
* The Election, musical interlude (1774)
* The Maid of the Oaks, masque with a comedy in 5 acts (1774)
* Belphagor, or The Wishes, comic opera afterpiece in 2 acts (1778)
# Sant'Agata Bolognese

Sant'Agata Bolognese (Western Bolognese: Sant'Èghete; City Bolognese: Sant'Ègata) is a small comune in the Metropolitan City of Bologna, Emilia-Romagna, in the north of Italy. It is notable for being the headquarters of the luxury automobile manufacturer Automobili Lamborghini.
It is named after Saint Agatha of Sicily.

## Economy

From the industry it is internationally known for hosting the headquarters of Lamborghini, which emerged as a company producing agricultural machinery, and later became a company of automobileis luxury.

## Famous people

* Nilla Pizzi, singer.
* Cinzia Bomoll, writer.
* Luciano Bovina, photoreporter and documentarian.
* Gilberto Canu, architect and writer.
* Ferruccio Lamborghini, founder of Lamborghini.

## Demographics

| Year | Pop. | ±% |
| 1861 | 3,799 | — |
| 1871 | 4,115 | +8.3% |
| 1881 | 3,934 | −4.4% |
| 1901 | 4,115 | +4.6% |
| 1911 | 4,449 | +8.1% |
| Year | Pop. | ±% |
| 1921 | 4,895 | +10.0% |
| 1931 | 5,327 | +8.8% |
| 1936 | 5,286 | −0.8% |
| 1951 | 5,348 | +1.2% |
| 1961 | 4,812 | −10.0% |
| Year | Pop. | ±% |
| 1971 | 4,641 | −3.6% |
| 1981 | 4,703 | +1.3% |
| 1991 | 4,927 | +4.8% |
| 2001 | 5,973 | +21.2% |
| 2018 | 7,344 | +23.0% |
Source: ISTAT Source :
# James Ricardo

James Ricardo is an American film director, screenwriter and producer.

## Filmography

| Year | Film | Director | Writer | Producer |
| 2003 | Hey DJ | | Y | Y |
| 2009 | Opie Gets Laid | Y | Y | Y |
| 2010 | Guillotine Guys | Y | Y | Y |
| 2012 | New Guy in Town | Y | Y | Y |