# 2021–22 Serie A de México season

The 2021–22 Serie A de México season is part of the third-tier football league of Mexico. The tournament began on 17 September 2021 and finished on 15 May 2022.

## Offseason Changes

* 27 teams will participate in the season.
* Since 2021–22 season, the season will once again be divided into two tournaments: Apertura and Clausura.
* On June 18, 2021, but was confirmed by the team a week later, Cruz Azul Hidalgo has been put on hiatus due to financial and economic issues within the club.
* After taking a hiatus due to COVID-19, Sporting Canamy, UAT and Yalmakán returns to participate in Serie A for 2021–22 season.
* On June 23, 2021, Aguacateros CDU returns to Serie B after an invite to participate in Serie A for the 2020–21 season when Serie B was suspended.
* On June 26, 2021, Fuertes de Fortín was promoted from Liga TDP, however, due to problems with its field, the team was sold to businessmen from Orizaba, who relocated it to their city and was renamed Montañeses F.C.
* On June 26, 2021 Club RC–1128 was promoted from Liga TDP, however, due to problems with its field, the team was merged with Catedráticos Elite F.C. and took the identity of this club, so it was relocated in Ameca.
* On June 29, 2021, Atlético San Luis dissolved due to a financial restructuring of the club.
* On June 30, 2021, Mineros de Fresnillo has been put on hiatus due to sponsorship funding issues. However, later Mineros de Zacatecas became part of the owners of the club, so the continuity of the team for the 2021–22 season was assured.
* On May 16, 2021, C.D. Irapuato sportively won the promotion to the Liga de Expansión MX. However, on June 3, 2021, the Mexican Football Federation announced the opening of a selection process to choose the club that would occupy the Liga Premier 3 place, because Irapuato must still meet some requirements to compete in the Liga de Expansión MX, three Liga Premier clubs (Durango, Irapuato and Matamoros), were chosen for an audit process that would determine the winner of the promotion. On July 5, 2021, it was confirmed that no team undergoing the certification audit approved the procedure, so there will be no club promoted from the Liga Premier.
* On July 15, 2021, CAFESSA Jalisco has been placed on hiatus, will not participate this season.
* On July 15, 2021, Coras de Nayarit F.C. announced it return to the League after a one-year hiatus, however, the team was renamed Coras F.C.
* On July 29, 2021, Zitácuaro has been placed on one–year hiatus due to financial issues, will not participate this season.
* On July 30, 2021, Pioneros de Cancún has been placed on hiatus.
* On July 30, 2021, Escorpiones, Leviatán, Lobos ULMX, Tritones Vallarta and Zap joined the league as expansion teams.
* On July 30, 2021, Chalco and Cuautla returned to Serie B.
* On July 30, 2021 Inter de Querétaro F.C. obtained its own official register in the league, as during the second half of the previous season the team entered the category but officially played as Azores de Hidalgo F.C.
* Before the start of the season Cañoneros Marina was renamed Cañoneros F.C.
* On September 10, 2021, Irapuato was put on hiatus due to the lack of agreement between the owners of the club and the Irapuato city council, this after the expiration of the rights to use the Stadium by the team management.

## Teams information
### Group 1

| Club | Manager | City | Stadium | Capacity | Affiliate |
| Alacranes de Durango | Héctor Jair Real | Durango City, Durango | Francisco Zarco | 18,000 | — |
| Catedráticos Elite | Jorge Humberto Torres | Ameca, Jalisco | Núcleo Deportivo y de Espectáculos Ameca | 7,000 | — |
| Cimarrones de Sonora | José Islas | Hermosillo, Sonora | Héroe de Nacozari | 18,747 | Cimarrones de Sonora |
| Colima | José Ernesto Santana (Interim) | Colima City, Colima | Olímpico Universitario de Colima | 11,812 | — |
| Coras | Manuel Naya Barba | Tepic, Nayarit | Olímpico Santa Teresita | 4,000 | – |
| Gavilanes de Matamoros | Lucas Ayala | Matamoros, Tamaulipas | El Hogar | 22,000 | — |
| Leones Negros UdeG | Ahuizotl Sánchez | Zapopan, Jalisco | Instalaciones Club Deportivo U.de G. Cancha 3 | 3,000 | Leones Negros UdeG |
| Mazorqueros | Jaime Durán | Ciudad Guzmán, Jalisco | Municipal Santa Rosa | 4,000 | — |
| Mineros de Fresnillo | Joaquín Moreno | Fresnillo, Zacatecas | Unidad Deportiva Minera Fresnillo | 6,000 | Mineros de Zacatecas |
| Saltillo | Jair García | Saltillo, Coahuila | Olímpico Francisco I. Madero | 7,000 | — |
| Tecos | Héctor Medrano | Zapopan, Jalisco | Tres de Marzo | 18,779 | — |
| Tritones Vallarta | Ulises Sánchez | Puerto Vallarta, Jalisco | Ciudad del Deporte San José del Valle | 4,000 | — |
| Tuzos UAZ | Rubén Hernández | Zacatecas City, Zacatecas | Carlos Vega Villalba | 20,068 | — |
| UAT | Jorge Dimas | Ciudad Victoria, Tamaulipas | Marte R. Gómez | 10,520 | Correcaminos UAT |

### Group 2

| Club | Manager | City | Stadium | Capacity | Affiliate |
| Cafetaleros de Chiapas | Miguel Ángel Casanova | Tuxtla Gutiérrez, Chiapas | Víctor Manuel Reyna | 29,001 | Cancún |
| Cañoneros | Carlos Alberto Valdéz | Milpa Alta, Mexico City | Momoxco | 3,500 | — |
| Dongu | José Ramón Gómez | Cuautitlán, State of Mexico | Los Pinos | 5,000 | — |
| Escorpiones | Héctor Mancilla | Cuernavaca, Morelos | Centenario | 14,800 | — |
| Inter Playa del Carmen | Carlos Bracamontes | Playa del Carmen, Quintana Roo | Unidad Deportiva Mario Villanueva Madrid | 7,500 | — |
| Inter Querétaro | José Antonio Soria | Querétaro City, Querétaro | Olímpico de Querétaro | 4,600 | — |
| La Piedad | Enrique Pérez | La Piedad, Michoacán | Juan N. López | 13,356 | — |
| Leviatán | José Alberto Pérez | Mexico City | Jesús Martínez Palillo | 6,000 | – |
| Lobos ULMX | Rowan Vargas | Celaya, Guanajuato | Miguel Alemán Valdés | 23,182 | Celaya |
| Montañeses | Víctor Hernández | Orizaba, Veracruz | Socum | 7,000 | – |
| Sporting Canamy | David Zaragoza (Interim) | Oaxtepec, Morelos | Olímpico de Oaxtepec | 9,000 | – |
| Yalmakán | Juan Carlos Montiel | Chetumal, Quintana Roo | José López Portillo | 6,600 | — |
| Zap | Jorge Hernández | Zapotlanejo, Jalisco | Miguel Hidalgo | 1,700 | – |
* ↑ Although the club registered the Estadio Olímpico de Querétaro as its official field, the team played its matches at the Unidad Deportiva La Cañada in Apertura 2021.
* ↑ Although the club registered the Estadio Jesús Martínez "Palillo" as its official field, they played some matches at the Neza 86 stadium in Apertura 2021
* ↑ Although the club registered the Estadio Socum as its official field, the team plays its matches at the Complejo Deportivo Orizaba Sur.

## Torneo Apertura
### Group 1
#### Standings

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Mazorqueros | 13 | 11 | 1 | 1 | 30 | 8 | +22 | 38 | Liguilla de Ascenso |
| 2 | Alacranes de Durango (C) | 13 | 9 | 3 | 1 | 24 | 10 | +14 | 31 | Liguilla de Ascenso |
| 3 | Saltillo | 13 | 9 | 3 | 1 | 25 | 12 | +13 | 31 | Liguilla de Ascenso |
| 4 | Coras | 13 | 6 | 2 | 5 | 20 | 15 | +5 | 24 | Liguilla de Ascenso |
| 5 | Gavilanes de Matamoros | 13 | 7 | 2 | 4 | 20 | 15 | +5 | 24 | 2021–22 Copa Conecta |
| 6 | Tecos | 13 | 6 | 3 | 4 | 18 | 14 | +4 | 22 | 2021–22 Copa Conecta |
| 7 | Tritones Vallarta | 13 | 5 | 2 | 6 | 21 | 26 | −5 | 18 | 2021–22 Copa Conecta |
| 8 | Colima | 13 | 5 | 2 | 6 | 18 | 18 | 0 | 17 | 2021–22 Copa Conecta |
| 9 | Leones Negros UdeG | 13 | 3 | 4 | 6 | 18 | 21 | −3 | 15 | |
| 10 | Cimarrones de Sonora | 13 | 4 | 2 | 7 | 20 | 20 | 0 | 14 | |
| 11 | UAT | 13 | 3 | 3 | 7 | 13 | 18 | −5 | 12 | |
| 12 | UAZ | 13 | 3 | 2 | 8 | 19 | 26 | −7 | 12 | |
| 13 | Catedráticos Elite | 13 | 3 | 2 | 8 | 13 | 27 | −14 | 11 | |
| 14 | Mineros de Fresnillo | 13 | 1 | 1 | 11 | 6 | 35 | −29 | 4 | |

#### Positions by Round

* Qualification to quarter-finals
* Last place in table
| Team ╲ Round | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
| Mazorqueros | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Durango | 2 | 4 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| Saltillo | 10 | 8 | 7 | 4 | 3 | 3 | 4 | 4 | 3 | 3 | 3 | 3 | 3 |
| Coras | 5 | 6 | 10 | 12 | 8 | 11 | 6 | 5 | 5 | 5 | 5 | 6 | 4 |
| Gavilanes | 8 | 9 | 9 | 5 | 7 | 6 | 8 | 7 | 4 | 4 | 4 | 5 | 5 |
| Tecos | 11 | 11 | 12 | 8 | 6 | 5 | 7 | 8 | 9 | 6 | 6 | 4 | 6 |
| Tritones Vallarta | 4 | 2 | 3 | 3 | 5 | 4 | 3 | 6 | 8 | 9 | 7 | 7 | 7 |
| Colima | 13 | 12 | 13 | 7 | 9 | 7 | 10 | 9 | 6 | 7 | 8 | 8 | 8 |
| Leones Negros | 6 | 10 | 11 | 13 | 13 | 9 | 5 | 3 | 7 | 8 | 9 | 9 | 9 |
| Cimarrones | 12 | 5 | 4 | 6 | 4 | 8 | 9 | 10 | 11 | 10 | 11 | 12 | 10 |
| UAT | 3 | 7 | 8 | 11 | 10 | 12 | 13 | 13 | 10 | 12 | 10 | 10 | 11 |
| UAZ | 9 | 13 | 6 | 10 | 11 | 13 | 11 | 12 | 13 | 11 | 12 | 11 | 12 |
| Catedráticos Elite | 7 | 3 | 5 | 9 | 12 | 10 | 12 | 11 | 12 | 13 | 13 | 13 | 13 |
| Fresnillo | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 |

#### Results

| Home \ Away | CAT | CIM | COL | COR | DUR | FRE | GAV | LNU | MAZ | SAL | TEC | TRV | UAT | UAZ |
| Catedráticos Elite | — | — | — | — | 2–3 | 3–1 | 1–3 | 3–2 | — | 1–0 | 0–2 | — | 1–1 | — |
| Cimarrones | 3–0 | — | 0–1 | 0–3 | — | — | — | — | 1–2 | 2–2 | — | — | 3–0 | 5–1 |
| Colima | 3–0 | — | — | — | 1–0 | 5–0 | — | 2–1 | 1–2 | 1–2 | — | — | — | — |
| Coras | 2–2 | — | 3–2 | — | 0–3 | 4–0 | — | — | 0–2 | 0–1 | — | — | — | — |
| Durango | — | 2–1 | — | — | — | 3–0 | 1–0 | 2–1 | — | — | 2–0 | 3–1 | 2–1 | — |
| Fresnillo | — | 3–2 | — | — | — | — | 0–1 | 0–3 | — | — | 1–1 | 0–1 | — | 0–4 |
| Gavilanes | — | 2–1 | 3–1 | 0–0 | — | — | — | — | 0–3 | — | — | 4–0 | 2–0 | 2–1 |
| Leones Negros | — | 1–2 | — | 2–0 | — | — | 2–2 | — | — | — | 0–0 | 3–3 | — | 1–0 |
| Mazorqueros | 2–0 | — | — | — | 1–1 | 1–0 | — | 3–0 | — | 1–2 | 3–0 | — | — | — |
| Saltillo | — | — | — | — | 1–1 | 4–2 | 3–1 | 3–1 | — | — | 3–1 | 2–0 | 1–0 | — |
| Tecos | — | 3–0 | 1–1 | 2–1 | — | — | 2–0 | — | — | — | — | 2–1 | — | 3–0 |
| Tritones Vallarta | 4–0 | 0–0 | 3–0 | 0–3 | — | — | — | — | 1–5 | — | — | — | 3–2 | 4–2 |
| UAT | — | — | 0–0 | 0–2 | — | 3–0 | — | 1–1 | 0–1 | — | 2–1 | — | — | 3–1 |
| UAZ | 2–0 | — | 3–0 | 1–2 | 1–1 | — | — | — | 2–4 | 1–1 | — | — | — | — |

### Group 2
#### Standings

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Cafetaleros de Chiapas | 12 | 10 | 1 | 1 | 31 | 8 | +23 | 35 | Liguilla de Ascenso |
| 2 | Inter Playa del Carmen | 12 | 8 | 3 | 1 | 36 | 8 | +28 | 30 | Liguilla de Ascenso |
| 3 | La Piedad | 12 | 7 | 3 | 2 | 20 | 8 | +12 | 29 | |
| 4 | Yalmakán | 12 | 8 | 0 | 4 | 22 | 12 | +10 | 26 | Liguilla de Ascenso |
| 5 | Zap | 12 | 7 | 0 | 5 | 21 | 18 | +3 | 22 | 2021–22 Copa Conecta |
| 6 | Inter Querétaro | 12 | 4 | 4 | 4 | 11 | 8 | +3 | 17 | 2021–22 Copa Conecta |
| 7 | Sporting Canamy | 12 | 4 | 2 | 6 | 11 | 21 | −10 | 14 | 2021–22 Copa Conecta |
| 8 | Montañeses | 12 | 3 | 4 | 5 | 15 | 16 | −1 | 13 | 2021–22 Copa Conecta |
| 9 | Lobos ULMX | 12 | 3 | 3 | 6 | 17 | 20 | −3 | 13 | |
| 10 | Dongu | 12 | 3 | 3 | 6 | 12 | 21 | −9 | 13 | |
| 11 | Cañoneros | 12 | 3 | 1 | 8 | 15 | 23 | −8 | 12 | |
| 12 | Escorpiones | 12 | 3 | 1 | 8 | 15 | 25 | −10 | 11 | |
| 13 | Leviatán | 12 | 2 | 1 | 9 | 8 | 46 | −38 | 7 | |
* ↑ C.F. La Piedad was excluded from the tournament play-offs due to failure to pay its obligations as an affiliate of the Liga Premier FMF.

#### Positions by Round

* Qualification to quarter-finals
* Last place in table
| Team ╲ Round | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
| Cafetaleros | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1† |
| Inter Playa | 1 | 4 | 3 | 2 | 2 | 3 | 3 | 3 | 3 | 2 | 3† | 3 | 2 |
| La Piedad | 2 | 1 | 2 | 3 | 3 | 2 | 2 | 2† | 2 | 3 | 2 | 2 | 3 |
| Yalmakán | 13 | 7 | 4 | 5 | 5 | 5† | 5 | 6 | 4 | 4 | 4 | 4 | 4 |
| Zap | 8† | 5 | 9 | 11 | 7 | 9 | 6 | 5 | 7 | 5 | 5 | 5 | 5 |
| Inter Querétaro | 5 | 6† | 7 | 9 | 10 | 10 | 10 | 7 | 5 | 6 | 6 | 6 | 6 |
| Sporting Canamy | 7 | 12 | 8 | 10 | 11† | 8 | 8 | 11 | 11 | 9 | 10 | 7 | 7 |
| Montañeses | 3 | 3 | 6† | 6 | 8 | 7 | 7 | 9 | 9 | 10 | 8 | 9 | 8 |
| Lobos ULMX | 6 | 10 | 12 | 12 | 13 | 13 | 13† | 13 | 13 | 13 | 13 | 12 | 9 |
| Dongu | 9 | 9 | 10 | 7 | 6 | 6 | 9 | 8 | 8† | 7 | 7 | 8 | 10 |
| Cañoneros | 11 | 8 | 5 | 4 | 4 | 4 | 4 | 4 | 6 | 8† | 9 | 10 | 11 |
| Escorpiones | 10 | 13 | 11 | 8 | 9 | 11 | 11 | 10 | 10 | 11 | 11 | 11† | 12 |
| Leviatán | 12 | 11 | 13 | 13† | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 13 | 13 |
* ↑ Pending match against Leviatán (since Week 11)
* ↑ Pending match against Sporting Canamy (since Week 11)

#### Results

| Home \ Away | CAF | CAÑ | DON | ESC | INP | INQ | LPD | LEV | LOB | MON | SCA | YAL | ZAP |
| Cafetaleros | — | — | 4–0 | — | 3–2 | — | — | — | 1–2 | 3–1 | 1–1 | — | 2–1 |
| Cañoneros | 1–3 | — | — | — | — | 0–1 | 0–2 | 4–0 | — | — | — | 0–1 | — |
| Dongu | — | 1–0 | — | 2–1 | — | — | — | — | 2–2 | 2–3 | 1–2 | — | 0–2 |
| Escorpiones | 0–1 | 2–1 | — | — | 0–5 | 1–1 | 1–4 | 3–4 | — | — | — | 0–1 | — |
| Inter Playa | — | 3–0 | 1–0 | — | — | — | 1–1 | — | 3–0 | — | 7–1 | 3–0 | — |
| Inter Querétaro | 0–2 | — | 3–0 | — | 0–0 | — | — | — | 1–1 | 0–0 | 1–0 | — | — |
| La Piedad | 0–1 | — | 2–2 | — | — | 1–0 | — | 3–1 | — | — | — | 1–2 | — |
| Leviatán | 0–7 | — | 1–1 | — | 0–5 | 0–3 | — | — | 1–4 | — | 0–3 | — | — |
| Lobos ULMX | — | 2–3 | — | 1–3 | — | — | 0–1 | — | — | 3–2 | 0–0 | — | 1–2 |
| Montañeses | — | 2–2 | — | 1–2 | 1–1 | — | 0–0 | 0–1 | — | — | — | 3–0 | 1–0 |
| Sporting Canamy | — | 0–2 | — | 2–1 | — | — | 0–3 | — | — | 2–1 | — | 0–3 | 0–1 |
| Yalmakán | 0–3 | — | 0–1 | — | — | 1–0 | — | 10–0 | 1–0 | — | — | — | — |
| Zap | — | 6–2 | — | 2–1 | 1–5 | 2–1 | 0–2 | 3–0 | — | — | — | 1–3 | — |

### Attendance
#### Per team

| | Home match played behind closed doors |
| | Away match |
| | Rest week |
| | Match canceled |
| | Highest attended match |
| | Lowest attended match |
| PPD | Match postponed |
| Team | Week | Week | Week | Week | Week | Week | Week | Week | Week | Week | Week | Week | Week | Total Att | Avg. | Total Pld |
| Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | Total Att | Avg. | Total Pld |
| Cafetaleros de Chiapas | | 3,000 | 1,000 | | 500 | | 500 | | 1,000 | | 0 | | | 6500 | 1083 | 6 |
| Catedráticos Elite | | 100 | | 100 | | 100 | | 40 | 50 | | 100 | | 100 | 590 | 84 | 7 |
| Cañoneros | 500 | | 150 | | 70 | | 50 | | | | | 50 | | 820 | 164 | 5 |
| Cimarrones de Sonora | | 0 | 0 | | 0 | | 0 | | 0 | | 0 | | 0 | 0 | 0 | 0 |
| Colima | 0 | | | 250 | | 150 | | 500 | | 400 | | 300 | | 1600 | 320 | 5 |
| Coras | 2,000 | | 0 | | 1,000 | | | 200 | | 500 | | 300 | | 4000 | 800 | 5 |
| Dongu | 150 | | 100 | | 200 | | | 100 | | 250 | | 50 | | 850 | 142 | 6 |
| Durango | 1,000 | | 1,000 | | 200 | | 1,000 | | 200 | | 900 | | 200 | 4500 | 643 | 7 |
| Escorpiones | 200 | | 200 | | 0 | | 0 | | 200 | | 100 | | 100 | 800 | 160 | 5 |
| Fresnillo | 100 | | 100 | | 50 | | 150 | | | 50 | | 50 | | 500 | 83 | 6 |
| Gavilanes | | 0 | | 300 | | 1,500 | | 850 | | 800 | 2,000 | | 100 | 5550 | 925 | 6 |
| Inter Playa | 250 | | 0 | | 250 | | 300 | | 200 | | | 250 | | 1250 | 250 | 5 |
| Inter Querétaro | | | | 0 | | 0 | 69 | | 100 | | 200 | | 100 | 469 | 117 | 4 |
| La Piedad | 300 | | 0 | | | 500 | | | | 400 | | 400 | | 1600 | 400 | 4 |
| Leones Negros | 80 | | 100 | | | 50 | | 50 | | 100 | | 100 | | 480 | 80 | 6 |
| Leviatán | | 150 | | | | 200 | | 150 | | 50 | | | 30 | 580 | 116 | 5 |
| Lobos ULMX | 150 | | | 800 | | 200 | | 150 | | 0 | | 20 | | 1320 | 264 | 5 |
| Mazorqueros | | 500 | | 300 | | 400 | | 600 | | 500 | | | 550 | 2850 | 475 | 6 |
| Montañeses | | 2,000 | | 2,000 | | 1,500 | | 1,000 | 2,000 | | 500 | | 1,200 | 10200 | 1457 | 7 |
| Saltillo | | 700 | | 300 | 500 | | 300 | | 500 | | 2,000 | | 1,500 | 5800 | 829 | 7 |
| Sporting Canamy | | 0 | | 100 | | 100 | | 50 | | 100 | | | 0 | 350 | 88 | 4 |
| Tecos | | 1,050 | | 200 | | 100 | | 400 | | 200 | | 200 | | 2150 | 358 | 6 |
| Tritones Vallarta | | 1,000 | | 1,000 | | 1,000 | 300 | | 300 | | 200 | | 500 | 4300 | 614 | 7 |
| UAT | 0 | | 500 | | 100 | | 100 | | 200 | | 0 | 100 | | 1000 | 200 | 5 |
| UAZ | 500 | | 150 | | 100 | | 200 | | 100 | | | 200 | | 1250 | 208 | 6 |
| Yalmakán | | 200 | | 200 | | | | 300 | | 500 | | 200 | | 1400 | 280 | 5 |
| Zap | | 400 | | 100 | 50 | | 100 | | 50 | | 200 | | 200 | 1100 | 157 | 7 |
| Total | 5,230 | 9,100 | 3,300 | 5,650 | 3,020 | 5,800 | 3,069 | 4,390 | 4,900 | 3,850 | 6,700 | 2,220 | 4,580 | 61809 | 418 | 148 |
Source: Liga Premier FMF

#### Highest and lowest

| Highest attended | Highest attended | Highest attended | Highest attended | Highest attended | Lowest attended | Lowest attended | Lowest attended | Lowest attended |
| Week | Home | Score | Away | Attendance | Home | Score | Away | Attendance |
| 1 | Coras | 2–2 | Catedráticos Elite | 2,000 | Leones Negros | 2–2 | Gavilanes de Matamoros | 80 |
| 2 | Cafetaleros de Chiapas | 3–2 | Inter Playa del Carmen | 3,000 | Catedráticos Elite | 3–1 | Mineros de Fresnillo | 100 |
| 3 | Alacranes de Durango | 3–1 | Tritones Vallarta | 1,000 | Deportivo Dongu | 1–2 | Sporting Canamy | 100 |
| 4 | Montañeses | 1–2 | Escorpiones | 2,000 | Zap | 1–5 | Inter Playa | 100 |
| 5 | Coras | 3–2 | Colima | 1,000 | Zap | 2–1 | Inter de Querétaro | 50 |
| 6 | Montañeses | 1–0 | Zap | 1,500 | Leones Negros | 2–0 | Coras | 50 |
| 7 | Alacranes de Durango | 2–0 | Tecos | 1,000 | Cañoneros | 0–2 | La Piedad | 50 |
| 8 | Montañeses | 1–1 | Inter Playa del Carmen | 1,000 | Catedráticos Elite | 1–1 | UAT | 40 |
| 9 | Montañeses | 0–1 | Leviatán | 2,000 | Zap | 1–3 | Yalmakán | 50 |
| 10 | Gavilanes de Matamoros | 2–0 | UAT | 800 | Leviatán | 0–5 | Inter Playa del Carmen | 50 |
| 11 | Gavilanes de Matamoros | 0–3 | Mazorqueros | 2,000 | Catedráticos Elite | 0–2 | Tecos | 100 |
| 12 | La Piedad | 1–0 | Inter Querétaro | 400 | Lobos ULMX | 3–2 | Montañeses | 20 |
| 13 | Saltillo | 4–2 | Mineros de Fresnillo | 1,500 | Leviatán | 1–4 | Lobos ULMX | 30 |
Source: Liga Premier FMF
* ^ Does not include matches played behind closed doors.

### Liguilla

The four best teams of each group play two games against each other on a home-and-away basis. The higher seeded teams play on their home field during the second leg. The winner of each match up is determined by aggregate score. In the quarterfinals and semifinals, if the two teams are tied on aggregate the higher seeded team advances. In the final, if the two teams are tied after both legs, the match goes to extra time and, if necessary, a penalty shoot-out.
| Quarter-finals | Quarter-finals | Quarter-finals | Quarter-finals | Quarter-finals | Semi-finals | Semi-finals | Semi-finals | Semi-finals | Semi-finals | Final | Final | Final | Final | Final |
| 2 | Cafetaleros de Chiapas | 2 | 3 | 5 | | | | | | | | | | |
| 7 | Coras | 0 | 3 | 3 | | | | | | | | | | |
| 7 | Coras | 0 | 3 | 3 | 2 | Cafetaleros de Chiapas | 1 | 3 | 4 (3) | | | | | |
| | | | | | 3 | Inter Playa del Carmen (p.) | 3 | 1 | 4 (5) | | | | | |
| 3 | Inter Playa del Carmen | 2 | 3 | 5 | 3 | Inter Playa del Carmen (p.) | 3 | 1 | 4 (5) | | | | | |
| 6 | Yalmakán | 0 | 1 | 1 | | | | | | | | | | |
| 6 | Yalmakán | 0 | 1 | 1 | | | | | | 3 | Inter Playa del Carmen | 0 | 0 | 0 |
| | | | | | | | | | | 4 | Durango | 1 | 0 | 1 |
| 1 | Mazorqueros | | | | | | | | | | | | | | 4 | Durango | 1 | 0 | 1 |
| | | | | | 1 | Mazorqueros | 0 | 0 | 0 | | | | | |
| | | | | | 4 | Durango | 0 | 2 | 2 | | | | | |
| 4 | Durango | 1 | 1 | 2 | 4 | Durango | 0 | 2 | 2 | | | | | |
| 5 | Saltillo | 0 | 0 | 0 | | | | | | | | | | |
* ↑ Mazorqueros was qualified directly to the semi–finals for his best average in the season, this after the exclusion of C.F. La Piedad of the play–offs.

#### Quarter-finals

The first legs were played on 1 and 2 December, and the second legs were played on 4 and 5 December 2021.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Cafetaleros de Chiapas | 5–3 | Coras | 2–0 | 3–3 |
| Durango | 2–0 | Saltillo | 1–0 | 1–0 |
| Inter Playa del Carmen | 5–1 | Yalmakán | 2–0 | 3–1 |

##### Second leg
#### Semi-finals

The first legs were played on 9 December, and the second legs were played on 12 December 2021.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Mazorqueros | 0–2 | Durango | 0–0 | 0–2 |
| Cafetaleros de Chiapas | 4–4 (3–5) | (p.) Inter Playa del Carmen | 1–3 | 3–1 |

##### Second leg
#### Final

The first leg was played on 15 December, and the second leg was played on 18 December 2021.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Inter Playa del Carmen | 0–1 | Durango | 0–1 | 0–0 |

##### Second leg

* Apertura 2021 winners
* Durango 3rd title

## Torneo Clausura

The Torneo Clausura began in January 2022.

### Group 1
#### Standings

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Mazorqueros (C) | 13 | 9 | 4 | 0 | 30 | 10 | +20 | 34 | Liguilla de Ascenso |
| 2 | Tritones Vallarta | 13 | 8 | 2 | 3 | 23 | 12 | +11 | 31 | Liguilla de Ascenso |
| 3 | Alacranes de Durango | 13 | 7 | 5 | 1 | 32 | 11 | +21 | 29 | Liguilla de Ascenso |
| 4 | Coras | 13 | 7 | 4 | 2 | 20 | 12 | +8 | 26 | Liguilla de Ascenso |
| 5 | Saltillo | 13 | 8 | 1 | 4 | 24 | 18 | +6 | 26 | |
| 6 | Cimarrones de Sonora | 13 | 5 | 3 | 5 | 19 | 15 | +4 | 20 | |
| 7 | Gavilanes de Matamoros | 13 | 3 | 8 | 2 | 14 | 9 | +5 | 19 | |
| 8 | UAZ | 13 | 3 | 6 | 4 | 22 | 20 | +2 | 17 | |
| 9 | Tecos | 13 | 3 | 6 | 4 | 13 | 19 | −6 | 17 | |
| 10 | Leones Negros UdeG | 13 | 3 | 4 | 6 | 13 | 22 | −9 | 13 | |
| 11 | Colima | 13 | 2 | 4 | 7 | 11 | 21 | −10 | 11 | |
| 12 | Mineros de Fresnillo | 13 | 1 | 6 | 6 | 17 | 29 | −12 | 11 | |
| 13 | UAT | 13 | 2 | 2 | 9 | 10 | 29 | −19 | 9 | |
| 14 | Catedráticos Elite | 13 | 0 | 5 | 8 | 9 | 30 | −21 | 5 | |

#### Positions by Round

* Qualification to quarter-finals
* Last place in table
| Team ╲ Round | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
| Mazorqueros | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 |
| Tritones Vallarta | 10 | 9 | 7 | 4 | 3 | 3 | 2 | 2 | 2 | 2 | 1 | 2 | 2 |
| Durango | 3 | 3 | 5 | 3 | 4 | 4 | 4 | 4 | 3 | 3 | 3 | 3 | 3 |
| Coras | 1 | 4 | 2 | 2 | 2 | 2 | 3 | 3 | 4 | 4 | 4 | 4 | 4 |
| Saltillo | 8 | 13 | 9 | 9 | 9 | 7 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Cimarrones | 4 | 2 | 3 | 7 | 5 | 5 | 7 | 7 | 6 | 6 | 7 | 8 | 6 |
| Gavilanes | 6 | 7 | 6 | 8 | 7 | 9 | 9 | 11 | 8 | 7 | 8 | 7 | 7 |
| UAZ | 12 | 10 | 4 | 6 | 8 | 6 | 6 | 6 | 7 | 8 | 6 | 6 | 8 |
| Tecos | 9 | 8 | 11 | 11 | 10 | 12 | 12 | 8 | 12 | 9 | 9 | 9 | 9 |
| Leones Negros | 7 | 11 | 12 | 12 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 12 | 10 |
| Colima | 13 | 12 | 8 | 5 | 6 | 8 | 8 | 10 | 11 | 12 | 12 | 11 | 11 |
| Fresnillo | 5 | 5 | 10 | 10 | 12 | 10 | 10 | 9 | 10 | 10 | 10 | 10 | 12 |
| UAT | 11 | 14 | 14 | 13 | 11 | 11 | 11 | 12 | 9 | 11 | 11 | 13 | 13 |
| Catedráticos Elite | 14 | 6 | 13 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 |

#### Results

| Home \ Away | CAT | CIM | COL | COR | DUR | FRE | GAV | LNU | MAZ | SAL | TEC | TRV | UAT | UAZ |
| Catedráticos Elite | — | 1–2 | 3–3 | 0–2 | — | — | — | — | 0–2 | — | — | 1–3 | — | 0–2 |
| Cimarrones | — | — | — | — | 1–1 | 2–2 | 0–0 | 4–0 | — | — | 0–1 | 1–3 | — | — |
| Colima | — | 0–1 | — | 0–1 | — | — | 0–0 | — | — | — | 0–1 | 0–2 | 1–0 | 1–1 |
| Coras | — | 2–1 | — | — | — | — | 1–1 | 3–0 | — | — | 1–0 | 1–0 | 2–0 | 2–2 |
| Durango | 6–0 | — | 6–1 | 0–0 | — | — | — | — | 1–1 | 3–1 | — | — | — | 1–1 |
| Fresnillo | 2–2 | — | 0–0 | 5–3 | 2–3 | — | — | — | 1–3 | 0–5 | — | — | 1–3 | — |
| Gavilanes | 3–0 | — | — | — | 1–1 | 1–0 | — | 1–1 | — | 1–2 | 1–1 | — | — | — |
| Leones Negros | 0–0 | — | 1–2 | — | 2–4 | 0–0 | — | — | 0–1 | 2–1 | — | — | 0–1 | — |
| Mazorqueros | — | 2–1 | 3–2 | 1–1 | — | — | 0–0 | — | — | — | — | 1–0 | 5–1 | 4–0 |
| Saltillo | 3–0 | 2–1 | 2–1 | 2–1 | — | — | — | — | 1–5 | — | — | — | — | 1–0 |
| Tecos | 1–1 | — | — | — | 0–2 | 2–2 | — | 1–1 | 2–2 | 1–2 | — | — | 2–1 | — |
| Tritones Vallarta | — | — | — | — | 1–0 | 4–1 | 1–0 | 1–2 | — | 2–1 | 1–1 | — | — | — |
| UAT | 1–1 | 0–2 | — | — | 0–4 | — | 0–3 | — | — | 1–1 | — | 1–3 | — | — |
| UAZ | — | 1–3 | — | — | — | 1–1 | 1–1 | 2–3 | — | — | 5–0 | 2–2 | 4–1 | — |

### Group 2
#### Standings

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification or relegation |
| 1 | Inter Playa del Carmen | 12 | 9 | 2 | 1 | 31 | 9 | +22 | 31 | Liguilla de Ascenso |
| 2 | Cafetaleros de Chiapas | 12 | 8 | 4 | 0 | 31 | 6 | +25 | 29 | Liguilla de Ascenso |
| 3 | Yalmakán | 12 | 7 | 3 | 2 | 15 | 4 | +11 | 27 | Liguilla de Ascenso |
| 4 | Escorpiones | 12 | 7 | 0 | 5 | 22 | 21 | +1 | 23 | Liguilla de Ascenso |
| 5 | Montañeses | 12 | 6 | 2 | 4 | 19 | 12 | +7 | 22 | |
| 6 | Zap | 12 | 6 | 1 | 5 | 22 | 17 | +5 | 21 | |
| 7 | Sporting Canamy | 12 | 5 | 3 | 4 | 17 | 14 | +3 | 20 | |
| 8 | La Piedad | 12 | 5 | 3 | 4 | 21 | 12 | +9 | 19 | |
| 9 | Lobos ULMX | 12 | 5 | 3 | 4 | 11 | 12 | −1 | 18 | |
| 10 | Cañoneros | 12 | 4 | 1 | 7 | 10 | 25 | −15 | 14 | |
| 11 | Inter Querétaro | 12 | 1 | 3 | 8 | 6 | 27 | −21 | 7 | |
| 12 | Dongu | 12 | 2 | 0 | 10 | 15 | 29 | −14 | 6 | |
| 13 | Leviatán | 12 | 0 | 1 | 11 | 6 | 38 | −32 | 1 | |

#### Positions by Round

* Qualification to quarter-finals
* Last place in table
| Team ╲ Round | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
| Inter Playa | 5 | 6 | 2 | 3 | 5 | 4 | 2 | 2 | 1 | 1 | 2† | 2 | 1 |
| Cafetaleros | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2† |
| Yalmakán | 6 | 2 | 4 | 4 | 2 | 3† | 6 | 7 | 7 | 3 | 3 | 3 | 3 |
| Escorpiones | 12 | 13 | 5 | 5 | 3 | 5 | 3 | 3 | 5 | 5 | 5 | 4† | 4 |
| Montañeses | 1 | 3 | 6† | 7 | 8 | 8 | 9 | 9 | 8 | 7 | 8 | 7 | 5 |
| Zap | 11† | 11 | 13 | 12 | 9 | 9 | 8 | 8 | 9 | 9 | 6 | 5 | 6 |
| Sporting Canamy | 3 | 4 | 3 | 2 | 4† | 2 | 4 | 4 | 3 | 4 | 4 | 6 | 7 |
| La Piedad | 9 | 7 | 8 | 9 | 7 | 7 | 5 | 6† | 4 | 6 | 7 | 8 | 8 |
| Lobos ULMX | 4 | 8 | 9 | 6 | 6 | 6 | 7† | 5 | 6 | 8 | 9 | 9 | 9 |
| Cañoneros | 7 | 9 | 10 | 11 | 12 | 11 | 10 | 10 | 10 | 10† | 10 | 10 | 10 |
| Inter Querétaro | 8 | 10† | 12 | 13 | 13 | 13 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
| Dongu | 13 | 5 | 7 | 8 | 10 | 10 | 12 | 12 | 12† | 12 | 12 | 12 | 12 |
| Leviatán | 10 | 12 | 11 | 10† | 11 | 12 | 13 | 13 | 13 | 13 | 13 | 13 | 13 |

#### Results

| Home \ Away | CAF | CAÑ | DON | ESC | INP | INQ | LPD | LEV | LOB | MON | SCA | YAL | ZAP |
| Cafetaleros | — | 8–0 | — | 4–2 | — | 4–0 | 2–0 | 4–0 | — | — | — | 1–0 | — |
| Cañoneros | — | — | 1–0 | 0–1 | 0–1 | — | — | — | 0–1 | 1–1 | 1–3 | — | 3–2 |
| Dongu | 1–2 | — | — | — | 1–4 | 6–1 | 0–4 | 2–1 | — | — | — | 0–2 | — |
| Escorpiones | — | — | 5–3 | — | — | — | — | — | 0–1 | 3–2 | 0–1 | — | 1–0 |
| Inter Playa | 0–0 | — | — | 6–1 | — | 3–0 | — | 4–0 | — | 4–1 | — | — | 3–2 |
| Inter Querétaro | — | 0–1 | — | 0–2 | — | — | 1–1 | 2–2 | — | — | — | 0–2 | 0–3 |
| La Piedad | — | 5–0 | — | 3–1 | 2–0 | — | — | — | 1–2 | 0–3 | 1–1 | — | 1–2 |
| Leviatán | — | 0–3 | — | 1–5 | — | — | 0–3 | — | — | 0–4 | — | 1–3 | 0–4 |
| Lobos ULMX | 0–0 | — | 2–0 | — | 1–4 | 0–0 | — | 1–0 | — | — | — | 0–1 | — |
| Montañeses | 1–1 | — | 3–0 | — | — | 1–2 | — | — | 1–0 | — | 1–0 | — | — |
| Sporting Canamy | 1–1 | — | 2–1 | — | 1–2 | 2–0 | — | 3–1 | 2–2 | — | — | — | — |
| Yalmakán | — | 3–0 | — | 0–1 | 0–0 | — | 0–0 | — | — | 1–0 | 2–0 | — | 1–1 |
| Zap | 1–4 | — | 2–1 | — | — | — | — | — | 3–1 | 0–1 | 2–1 | — | — |

### Attendance
#### Per team

| Pos | Team | Total | High | Low | Average | Change |
| 1 | Cafetaleros de Chiapas | 12,500 | 4,000 | 1,000 | 2,083 | +92.3%$^†$ |
| 2 | Durango | 4,900 | 1,500 | 300 | 817 | +27.1%$^†$ |
| 3 | Coras | 4,950 | 1,500 | 200 | 707 | −11.6%$^†$ |
| 4 | Montañeses | 3,500 | 1,000 | 300 | 700 | −52.0%$^†$ |
| 5 | Saltillo | 2,900 | 1,000 | 200 | 483 | −41.7%$^†$ |
| 6 | Yalmakán | 2,450 | 500 | 200 | 350 | +25.0%$^†$ |
| 7 | La Piedad | 2,050 | 500 | 150 | 342 | −14.5%$^1$ |
| 8 | Inter Playa | 1,700 | 400 | 200 | 283 | +13.2%$^†$ |
| 9 | Tritones Vallarta | 1,600 | 400 | 100 | 267 | −56.5%$^†$ |
| 10 | Mazorqueros | 1,870 | 500 | 70 | 267 | −43.8%$^†$ |
| 11 | Tecos | 1,400 | 500 | 100 | 233 | −34.9%$^1$ |
| 12 | Gavilanes | 700 | 300 | 100 | 175 | −81.1%$^2$ |
| 13 | Colima | 1,200 | 300 | 50 | 171 | −46.6%$^†$ |
| 14 | Escorpiones | 850 | 200 | 150 | 170 | +6.3%$^†$ |
| 15 | Dongu | 820 | 300 | 50 | 137 | −3.5%$^†$ |
| 16 | UAZ | 950 | 500 | 50 | 136 | −34.6%$^†$ |
| 17 | Lobos ULMX | 780 | 200 | 50 | 130 | −50.8%$^†$ |
| 18 | Inter Querétaro | 350 | 250 | 50 | 117 | 0.0%$^2$ |
| 19 | Sporting Canamy | 550 | 150 | 50 | 110 | +25.0%$^1$ |
| 21 | Leviatán | 500 | 200 | 50 | 100 | −13.8%$^†$ |
| 20 | Zap | 400 | 100 | 50 | 80 | −49.0%$^†$ |
| 22 | Fresnillo | 552 | 102 | 50 | 79 | −4.8%$^†$ |
| 23 | UAT | 200 | 100 | 50 | 67 | −66.5%$^2$ |
| 24 | Cañoneros | 450 | 100 | 20 | 64 | −61.0%$^†$ |
| 25 | Leones Negros | 400 | 100 | 50 | 57 | −28.7%$^†$ |
| 26 | Catedráticos Elite | 300 | 100 | 30 | 50 | −40.5%$^†$ |
| 27 | Cimarrones de Sonora | 50 | 50 | 50 | 50 | n/a$^5$ |
| | League total | 48,572 | 4,000 | 20 | 322 | −23.0%$^†$ |
Source: Liga Premier FMF Notes: The number listed represents the amount of home matches the club played behind closed doors.

#### Highest and lowest

| Highest attended | Highest attended | Highest attended | Highest attended | Highest attended | Lowest attended | Lowest attended | Lowest attended | Lowest attended |
| Week | Home | Score | Away | Attendance | Home | Score | Away | Attendance |
| 1 | Cafetaleros de Chiapas | 4–2 | Escorpiones | 2,000 | Catedráticos Elite | 0–2 | Coras | 50 |
| 2 | Durango | 3–1 | Saltillo | 600 | Cañoneros | 1–1 | Montañeses | 20 |
| 3 | Tecos | 1–1 | Leones Negros | 500 | Catedráticos Elite | 0–2 | UAZ | 30 |
| 4 | Cafetaleros de Chiapas | 4–0 | Inter de Querétaro | 1,000 | Mineros de Fresnillo | 1–3 | Mazorqueros | 50 |
| 5 | Montañeses | 1–1 | Cafetaleros de Chiapas | 800 | Colima | 0–1 | Coras | 50 |
| 6 | Durango | 1–1 | Mazorqueros | 1,500 | UAZ | 5–0 | Tecos | 50 |
| 7 | Coras | 2–0 | UAT | 1,200 | Catedráticos Elite | 1–3 | Tritones Vallarta | 50 |
| 8 | Cafetaleros de Chiapas | 1–0 | Yalmakán | 2,000 | Inter Querétaro | 2–2 | Leviatán | 50 |
| 9 | Coras | 2–2 | UAZ | 550 | Cañoneros | 0–1 | Inter Playa | 50 |
| 10 | Cafetaleros de Chiapas | 2–0 | La Piedad | 2,500 | Zap | 3–1 | Lobos ULMX | 50 |
| 11 | Coras | 2–1 | Cimarrones de Sonora | 500 | Leones Negros | 2–1 | Saltillo | 50 |
| 12 | Cafetaleros de Chiapas | 8–0 | Cañoneros | 4,000 | Catedráticos Elite | 3–3 | Colima | 20 |
| 13 | Coras | 1–0 | Tritones Vallarta | 1,500 | Cañoneros | 3–2 | Zap | 50 |
Source: Liga Premier FMF
* ^ Does not include matches played behind closed doors.

### Liguilla

The four best teams of each group play two games against each other on a home-and-away basis. The higher seeded teams play on their home field during the second leg. The winner of each match up is determined by aggregate score. In the quarterfinals and semifinals, if the two teams are tied on aggregate the higher seeded team advances. In the final, if the two teams are tied after both legs, the match goes to extra time and, if necessary, a penalty shoot-out.
| Quarter-finals | Quarter-finals | Quarter-finals | Quarter-finals | Quarter-finals | Semi-finals | Semi-finals | Semi-finals | Semi-finals | Semi-finals | Final | Final | Final | Final | Final |
| 1 | Mazorqueros | 2 | 7 | 9 | | | | | | | | | | |
| 8 | Escorpiones | 1 | 0 | 1 | | | | | | | | | | |
| 8 | Escorpiones | 1 | 0 | 1 | 1 | Mazorqueros (p.) | 2 | 0 | 2 (5) | | | | | |
| | | | | | 4 | Tritones Vallarta | 1 | 1 | 2 (4) | | | | | |
| 4 | Tritones Vallarta | 1 | 1 | 2 | 4 | Tritones Vallarta | 1 | 1 | 2 (4) | | | | | |
| 5 | Yalmakán | 0 | 1 | 1 | | | | | | | | | | |
| 5 | Yalmakán | 0 | 1 | 1 | | | | | | 1 | Mazorqueros (p.) | 0 | 0 | 0 (4) |
| | | | | | | | | | | 3 | Cafetaleros de Chiapas | 0 | 0 | 0 (2) |
| 2 | Inter Playa del Carmen | 2 | 1 | 3 | | | | | | | | | | | 3 | Cafetaleros de Chiapas | 0 | 0 | 0 (2) |
| 7 | Coras | 1 | 1 | 2 | | | | | | | | | | |
| 7 | Coras | 1 | 1 | 2 | 2 | Inter Playa del Carmen | 0 | 0 | 0 | | | | | |
| | | | | | 3 | Cafetaleros de Chiapas | 0 | 1 | 1 | | | | | |
| 3 | Cafetaleros de Chiapas | 1 | 1 | 2 | 3 | Cafetaleros de Chiapas | 0 | 1 | 1 | | | | | |
| 6 | Durango | 1 | 0 | 1 | | | | | | | | | | |

#### Quarter-finals

The first legs were played on 14, 15 and 16 April, and the second legs were played on 22 and 23 April 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Mazorqueros | 9–1 | Escorpiones | 2–1 | 7–0 |
| Tritones Vallarta | 2–1 | Yalmakán | 1–0 | 1–1 |
| Inter Playa del Carmen | 3–2 | Coras | 2–1 | 1–1 |
| Cafetaleros de Chiapas | 2–1 | Durango | 1–1 | 1–0 |

##### Second leg
#### Semi-finals

The first legs were played on 27 April, and the second legs were played on 30 April 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Mazorqueros (p.) | 2–2 (5–4) | Tritones Vallarta | 2–1 | 0–1 |
| Inter Playa del Carmen | 0–1 | Cafetaleros de Chiapas | 0–0 | 0–1 |

##### Second leg
#### Final

The first leg was played on 5 May, and the second leg was played on 8 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Mazorqueros | 0–0 (4–2) | Cafetaleros de Chiapas | 0–0 | 0–0 |

##### Second leg

* Clausura 2022 winners
* Mazorqueros 1st title

## Coefficient table

| P | Team | Pts | G | Pts/G | GD |
| 1 | Mazorqueros | 72 | 26 | 2.769 | +43 |
| 2 | Cafetaleros de Chiapas | 64 | 24 | 2.667 | +47 |
| 3 | Inter Playa del Carmen | 61 | 24 | 2.542 | +51 |
| 4 | Alacranes de Durango | 60 | 26 | 2.308 | +35 |
| 5 | Yalmakán | 53 | 24 | 2.208 | +21 |
| 6 | Saltillo | 57 | 26 | 2.192 | +19 |
| 7 | La Piedad | 48 | 24 | 2.000 | +21 |
| 8 | Coras | 50 | 26 | 1.923 | +14 |
| 9 | Tritones Vallarta | 49 | 26 | 1.885 | +6 |
| 10 | Zap | 43 | 24 | 1.792 | +8 |
| 11 | Gavilanes de Matamoros | 42 | 26 | 1.615 | +10 |
| 12 | Tecos | 39 | 26 | 1.500 | –2 |
| 13 | Montañeses | 35 | 24 | 1.458 | +7 |
| 14 | Sporting Canamy | 34 | 24 | 1.417 | –7 |
| 15 | Escorpiones | 34 | 24 | 1.417 | –7 |
| 16 | Cimarrones de Sonora | 34 | 26 | 1.308 | +4 |
| 17 | Lobos ULMX | 31 | 24 | 1.292 | –5 |
| 18 | UAZ | 29 | 26 | 1.115 | –5 |
| 19 | Cañoneros | 26 | 24 | 1.083 | –23 |
| 20 | Colima | 28 | 26 | 1.077 | –10 |
| 21 | Leones Negros UdeG | 28 | 26 | 1.077 | –11 |
| 22 | Inter Querétaro | 24 | 24 | 1.000 | –18 |
| 23 | UAT | 21 | 26 | 0.808 | –24 |
| 24 | Dongu | 19 | 24 | 0.792 | –24 |
| 25 | Catedráticos Elite | 16 | 26 | 0.615 | –35 |
| 26 | Mineros de Fresnillo | 15 | 26 | 0.577 | –41 |
| 27 | Leviatán | 8 | 24 | 0.333 | –69 |
Last updated: April 10, 2022 Source: Liga Premier FMF P = Position; G = Games played; Pts = Points; Pts/G = Ratio of points to games played; GD = Goal difference

## Promotion Final

The Promotion Final is a series of matches played by the champions of the tournaments Apertura and Clausura, the game is played to determine the winning team of the promotion to Liga de Expansión MX, as long as the winning team meets the league requirements.
The first leg were played on 12 May 2022, and the second leg were played on 15 May 2022.
| Team 1 | Agg.Tooltip Aggregate score | Team 2 | 1st leg | 2nd leg |
| Mazorqueros | 2–5 | Durango | 0–1 | 2–4 |

### Second leg

* 2021–22 winners
* Durango 3rd title