# C13orf16

Chromosome 13 open reading frame 16 is a protein in homo sapiens encoded by the C13orf16 gene. There is one alias name, TEX29, for the high testis expression of this gene due to spermatogenesis.
C13orf16 in Homo sapiens is located on the long arm of chromosome 13 at q34. The spliced gene is 859 nucleotides, has 7 exons and is located on the plus strand.
C13orf16 is ubiquitously expressed among human tissues, with significantly higher expression in brain tissues, specifically in the hippocampus and cerebellum.

## Protein

The human C13orf16 protein encoded by the mRNA sequence is 174 amino acids in length. The molecular weight without post-transitional modifications is 18.4 KD and the basal isoelectric point value is 4.99 pH.
Human C13orf16 is localized both intracellularly, in the nucleus, and extracellularly with one transmembrane domain from amino acids 80-102. There are no asparagines, resulting in no N-glycosylation sites.
There are five interacting proteins for human C13orf16, all identified by physical interactions.
Interacting proteins for human C13orf16 protein :
| Abbreviated Name | Full Name | Brief Description |
| PTS | 6-Pyruvoyltetrahydropterin Synthase | Elimination of inorganic triphosphate from dihydroneopterin triphosphate (2nd and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP) |
| SLC16A2 | Solute Carrier Family 16 Member 2 | Non-redundant, thyroid hormone transporter |
| STEAP3 | STEAP Family Member 3, Metalloreductase | Iron transporter, can reduce both iron (Fe3+) and copper (Cu2+) cations |
| SLC4A7 | Solute Carrier Family 4 Member 7 | Sodium bicarbonate cotransporter, transports sodium and bicarbonate ions in a 1:1 ratio, considered an electroneutral cotransporter |
| SLC6A15 | Solute Carrier Family 6 Member 15 | Neutral amino acid transporter, predicted to play a role in neuronal amino acid transport |

## Homology and evolution

The C13orf16 protein was only found to have orthologs in placental mammals and most distantly found in the Proboscidea taxonomic group. In the table below, orthologs are sorted first by estimated date of divergence, then by sequence identity to the human C13orf16 protein.
Orthologs of human C13orf16 protein :
| Genus & Species | Common Name | Taxonomic Group | Date of Divergence (MYA) | Accession Number | Sequence Length (aa) | Sequence Identity to Human Protein | Sequence Similarity to Human Protein |
| Homo sapiens | Human | Primates | 0 | NP_001290062 | 174 | 100% | 100% |
| Nomascus leucogenys | Northern Gibbon | Primates | 19.5 | XP_012362426 | 173 | 91% | 94.80% |
| Macaca mulatta | Rhesus Macaque | Primates | 28.8 | XP_028693172 | 182 | 44.30% | 51.70% |
| Cebus imitator | White-faced Capuchin | Primates | 43 | XP_037585341 | 179 | 70.60% | 77.80% |
| Peromyscus maniculatus bairdii | Deer Mouse | Rodentia | 87 | XP_042118685 | 176 | 27.20% | 38.60% |
| Peromyscus leucopus | White-Footed Mouse | Rodentia | 87 | XP_037067483 | 176 | 26.70% | 38.60% |
| Oryctolagus cuniculus | European Rabbit | Lagomorpha | 87 | XP_051685630 | 143 | 25.80% | 30.80% |
| Phoca vitulina | Harbor Seal | Carnivora | 94 | XP_032258415 | 162 | 34% | 43.50% |
| Neofelis nebulosa | Clouded Leopard | Carnivora | 94 | XP_058598545 | 165 | 34.00% | 45.20% |
| Phacochoerus africanus | Warthog | Artiodactyla | 94 | XP_047612273 | 171 | 32.10% | 41.80% |
| Balaenoptera ricei | Rice's Whale | Artiodactyla | 94 | XP_059759229 | 147 | 29.30% | 36.40% |
| Hyaena hyaena | Striped Hyena | Carnivora | 94 | XP_039082615 | 151 | 29.00% | 39.40% |
| Ailuropoda melanoleuca | Giant Panda | Carnivora | 94 | XP_034521380 | 147 | 25% | 31.20% |
| Hippopotamus amphibius kiboko | East African Hippo | Artiodactyla | 94 | XP_057563793 | 147 | 23.70% | 34.30% |
| Artibeus jamaicensis | Jamacian Fruit Bat | Chiroptera | 94 | XP_036993559.2 | 149 | 21.70% | 30.40% |
| Vulpes lagopus | Arctic Fox | Carnivora | 94 | XP_041586767 | 178 | 21.7%% | 30.0%% |
| Equus caballus | Horse | Perissodactyla | 94 | XP_005601398 | 136 | 20.80% | 27.00% |
| Talpa occidentalis | Spanish Mole | Talpidae | 94 | XP_037383406 | 162 | 19.30% | 25.00% |
| Diceros bicornis minor | Black Rhino | Perissodactyla | 94 | XP_058403718 | 181 | 18.80% | 24% |
| Elephas maximus indicus | Indian Elephant | Proboscidea | 99 | XP_049723476 | 145 | 23.80% | 35.10% |