OpenLLM-France/wikimedia huggingface dataset:
# 1937 Notre Dame Fighting Irish football team

The 1937 Notre Dame Fighting Irish football team represented the University of Notre Dame during the 1937 college football season.

## Schedule

| Date | Opponent | Rank | Site | Result | Attendance |
| October 2 | Drake | | Notre Dame StadiumNotre Dame, IN | W 21–0 | 41,000 |
| October 9 | at Illinois | | Memorial StadiumChampaign, IL | T 0–0 | 42,253 |
| October 16 | at Carnegie Tech | | Pittsburgh, PA | L 7–9 | 30,418 |
| October 23 | Navy | | Notre Dame StadiumNotre Dame, IN (rivalry) | W 9–7 | 45,000 |
| October 30 | at No. 4 Minnesota | | Memorial StadiumMinneapolis, MN | W 7–6 | 63,237 |
| November 6 | No. 3 Pittsburgh | No. 12 | Notre Dame StadiumNotre Dame, IN (rivalry) | L 6–21 | 54,309 |
| November 13 | vs. Army | No. 18 | Yankee StadiumBronx, NY (rivalry) | W 7–0 | 76,359 |
| November 20 | at Northwestern | No. 12 | Dyche StadiumEvanston, IL (rivalry) | W 7–0 | 42,573 |
| November 27 | USC | No. 9 | Notre Dame StadiumNotre Dame, IN (rivalry) | W 13–6 | 28,920 |
| Rankings from AP Poll released prior to the game |||||||
# Niederdürenbach

Niederdürenbach is a municipality in the district of Ahrweiler, in Rhineland-Palatinate, Germany.
# Niederelbe

The Niederelbe (i.e. Lower Elbe) is a 108 kilometers (67 miles) long section of the river Elbe, from western Hamburg downstream to its mouth into the North Sea near Cuxhaven. Starting at Mühlenberger Loch [de; nds] (or Elbe kilometer 634) near Finkenwerder, Hamburg, it gradually widens from 2 km (1.2 mi) to 18 km (11 mi). Once passing the Hamburg state border, the Niederelbe also forms the border between the states of Lower Saxony and Schleswig-Holstein.
The Niederelbe forms part of the Elbe section named the Unterelbe (i. e. Lower ("Under") Elbe), comprising all parts of the Elbe influenced by the North Sea's tides, starting further inland at the sluice in Geesthacht (or Elbe kilometer 586).
# Dobrić, Virovitica-Podravina County

Dobrić is an uninhabited settlement in Croatia, in the municipality of Voćin, Virovitica-Podravina County.

## Demographics

According to the 2011 census, the village of Dobrić has no inhabitants.
The 1991 census recorded that 96.88% of the village population were ethnic Serbs (62/64), 1.56% were Yugoslavs (1/64) and 1.56% were of other ethnic origin (1/64).
* v
# Berghia creutzbergi

Berghia creutzbergi is a species of sea slug, an aeolid nudibranch. It is a shell-less marine gastropod mollusc in the family Aeolidiidae.

## Distribution

This species is an inhabitant of the Tropical Western Atlantic Ocean present in Brazil, Curaçao, Venezuela, Barbados, Bahamas, the Cayman Islands, the Caribbean coast of Costa Rica, Cuba and Florida.

## Description

Berghia creutzbergi has a maximum reported size of 30 mm.

## Habitat

This species is found in depths from 0 to 5 m.
# Chambers House

Chambers House, or Chambers Farmstead, or Chambers Farm, or Chambers Barn or variations, may refer to the following in the United States:
* Chambers-Robinson House, Sheffield, Alabama, listed on the National Register of Historic Places (NRHP) in Colbert County, Alabama
* Chambers Ranch, Colorado Springs, Colorado, listed on the National Register of Historic Places (NRHP) in El Paso County, Colorado
* Chambers House (College Avenue, Newark, Delaware), listed on the NRHP in New Castle County, Delaware
* Chambers House (Hopkins Bridge Road, Newark, Delaware), listed on the NRHP in New Castle County, Delaware
* William Chambers House, Carnesville, Georgia, listed on the NRHP in Banks County, Georgia
* Robert Chambers House, Burlington, Kentucky, listed on the NRHP in Boone County, Kentucky
* A. E. Chambers Octagonal Barn, Petersburg, Kentucky, listed on the NRHP in Boone County, Kentucky
* C. Scott Chambers House and Funeral Parlor, Walton, Kentucky, listed on the NRHP in Boone County, Kentucky
* Whittaker Chambers Farm, Westminster, Maryland, NRHP-listed
* John Chambers House, St. Ignace, Michigan, NRHP-listed
* Maxwell Chambers House, Salisbury, North Carolina, listed on the NRHP in Rowan County, North Carolina
* Chambers-Morgan Farm, White Store, North Carolina, listed on the NRHP in Anson County, North Carolina
* Brigman-Chambers House, Weaverville, North Carolina, listed on the NRHP in Buncombe County, North Carolina
* Matthew C. Chambers Barn, Albany, Oregon, listed on the NRHP in Linn County, Oregon
* Frank L. and Ida H. Chambers House, Eugene, Oregon, NRHP-listed
* Fred E. Chambers House and Grounds, Eugene, Oregon, NRHP-listed
* Joseph and Virginia Chambers Farmstead, Newberg, Oregon, listed on the NRHP in Yamhill County, Oregon
* C. E. Chambers House, Mitchell, South Dakota, listed on the NRHP in Davison County, South Dakota
* Samuel A. Chambers House, Abilene, Texas, listed on the NRHP in Taylor County, Texas
* Chambers House (Beaumont, Texas), a historic house museum of Texas
* Hodges-Hardy-Chambers House, Wichita Falls, Texas, listed on the NRHP in Wichita County, Texas
* Pearl and Eva Chambers House, Eau Claire, Wisconsin, listed on the NRHP in Eau Claire County, Wisconsin
* Chambers-Markle Farmstead, La Crosse, Wisconsin, listed on the NRHP in La Crosse County, Wisconsin
* Andy Chambers Ranch Historic District, Moose, Wyoming, NRHP-listed
# Corral (disambiguation)

A corral is an enclosure for livestock.
Corral may also refer to:

## Places

* Corral, Chile, a town and municipality in Chile
* Corral, Idaho, an unincorporated community in the United States
* Corral Bay

## Other uses

* Corral (defense), a defense circle of wagons
* Corral (film), a 1954 National Film Board of Canada documentary
* Corral (puzzle), a logic puzzle
* Corral (surname), a surname
# Mount Myōken

Mount Myōken (妙見山) is the name of several mountains in Japan:
* Mount Myōken (Nose) on the borders of Hyogo and Osaka prefectures - see Myoken Cable
* Mount Myōken (Tajima) in Hyogo Prefecture
# Moustier-en-Fagne

Moustier-en-Fagne (French pronunciation:) is a commune in the Nord department in northern France.

## Heraldry

| Arms of Moustier-en-Fagne | The arms of Moustier-en-Fagne are blazoned : Gules, 2 keys in saltire addorsed Or. (Hon-Hergies, Moustier-en-Fagne and Taisnières-sur-Hon use the same arms.) |
# Target Island

Target Island is a 1944 war novel by the British writer John Brophy. It was published by Collins in London and Harper in New York. It takes place during the Axis Siege of Malta during the Second World War. While popular, it did not repeat the great success of Brophy's previous novel Immortal Sergeant set during the North African Campaign. John Hampson writing in The Spectator gave it a fairly negative review alongside Vicki Baum's Berlin Hotel and noted "here again are major and minor figures, love-affairs, raids, and alarms, amid the panoply of modern war. And yet nothing has been added to the epic of Malta that we didn't already know. However, its film possibilities will be obvious to the cinema fan". In the event the novel was not adapted for the screen unlike several others of Brophy's work, although much of its settings and themes featured in the 1953 film Malta Story.
# 2010 World Wrestling Championships – Women's freestyle 67 kg

The women's freestyle 67 kilograms is a competition featured at the 2010 World Wrestling Championships, and was held at the Olympic Stadium in Moscow, Russia on 10 September.
This freestyle wrestling competition consists of a single-elimination tournament, with a repechage used to determine the winner of two bronze medals.

## Results
### Legend

* F — Won by fall
* R — Retired
* WO — Won by walkover

### Final

| Final | Final | Final | Final |
| Martine Dugrenier (CAN) | 0 | 6 | 7 |
| Yelena Shalygina (KAZ) | 2 | 0 | 0 |

### Top half

| Round of 16 | Round of 16 | Round of 16 | Round of 16 | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| Alena Kartashova (RUS) | 1 | 0 | 0 | | | | | | |
| Ifeoma Iheanacho (NGR) | 0 | 2 | 4$^F$ | | | | | | |
| | | | | Ifeoma Iheanacho (NGR) | 1 | 8$^F$ | | | |
| | | | | Maria Selmaier (GER) | 0 | 0 | | | |
| Maria Selmaier (GER) | 3 | 0 | 4$^F$ | | | | | | |
| Enas Mostafa (EGY) | 2 | 5 | 0 | | | | | | |
| | | | | | | | Ifeoma Iheanacho (NGR) | 0 | 1 |
| | | | | | | | Martine Dugrenier (CAN) | 3 | 5 |
| Maja Erlandsen (NOR) | 0 | | | | | | | | |
| Martine Dugrenier (CAN) | 3$^F$ | | | | | | | | |
| | | | | Martine Dugrenier (CAN) | 1 | 3 | | | |
| | | | | Mami Shinkai (JPN) | 0 | 0 | | | |
| Mami Shinkai (JPN) | 9 | 5 | | | | | | | |
| Yanira Morales (PUR) | 3 | 1 | | | | | | | |

### Bottom half

| Round of 32 | Round of 32 | Round of 32 | Round of 16 | Round of 16 | Round of 16 | Round of 16 | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| | | | Kristie Davis (USA) | 1 | 0 | | | | | | | | | |
| | | | Alla Cherkasova (UKR) | 3 | 1 | | | | | | | | | |
| | | | | | | | Alla Cherkasova (UKR) | 4 | 0 | 2 | | | | |
| | | | | | | | Chen Ying (CHN) | 0 | 1 | 0 | | | | |
| | | | Volha Khilko (BLR) | 3 | 0 | 0 | | | | | | | | |
| | | | Chen Ying (CHN) | 0 | 3 | 3 | | | | | | | | |
| | | | | | | | | | | | Alla Cherkasova (UKR) | 0 | 3 | 0 |
| | | | | | | | | | | | Yelena Shalygina (KAZ) | 1 | 0 | 6 |
| | | | Badrakhyn Odonchimeg (MGL) | 0 | 0 | | | | | | | | | |
| | | | Nadya Sementsova (AZE) | 1 | 1 | | | | | | | | | |
| | | | | | | | Nadya Sementsova (AZE) | 3 | 0 | 0 | | | | |
| | | | | | | | Yelena Shalygina (KAZ) | 0 | 3 | 2 | | | | |
| | | | Burcu Örskaya (TUR) | 0 | 0 | | | | | | | | | |
| Yelena Shalygina (KAZ) | 6 | 4$^F$ | Yelena Shalygina (KAZ) | 2 | 2 | | | | | | | | | |
| Elgiza Anarbekova (KGZ) | 0 | 0 | | | | | | | | | | | | |

### Repechage

| Repechage round 1 | Repechage round 1 | Repechage round 1 | Repechage round 2 | Repechage round 2 | Repechage round 2 | Bronze medals | Bronze medals | Bronze medals |
| | | | Maja Erlandsen (NOR) | | | Mami Shinkai (JPN) | 0 | |
| | | | Mami Shinkai (JPN) | W | O | Ifeoma Iheanacho (NGR) | 5$^F$ | |
| Elgiza Anarbekova (KGZ) | 0 | 0 | Burcu Örskaya (TUR) | 0 | 0 | Nadya Sementsova (AZE) | 0 | 0$^R$ |
| Burcu Örskaya (TUR) | 3 | 5$^F$ | Nadya Sementsova (AZE) | 1 | 1 | Alla Cherkasova (UKR) | 1 | 1 |
# Kagayakeru Hoshi

Kagayakeru Hoshi (輝ける星, lit. "Shining Star") is the second single by Miho Komatsu and her first single released under the Amemura-O-Town Record label. The single reached #20 on the charts in its first week and sold 19,380 copies. It charted for five weeks total and sold 47,850 copies.

## Track listing

All lyrics are written by Miho Komatsu; all music is composed by Miho Komatsu

## Usage in media

* Kagayakeru Hoshi
** for anime television series Ninpen Manmaru as ending theme song
# Motuora

Motuora is an 80 ha (200 acres) island nature reserve in the western Hauraki Gulf, on the north-eastern coast of New Zealand's North Island. It lies some 6.2 km (3.9 mi) south-west of Kawau Island, 5 km (3.1 mi) east of Mahurangi Heads and 35 kilometres (22 mi) north of the city of Auckland.

## History

Although Motuora now has no permanent residents, it has a history of human occupation and was used for farming during much of the 20th century, when the native coastal forest was cleared apart from remnant patches along the cliffs. The island was bought by the government in 1965 as a recreation reserve. In 1990 a program of ecological restoration began, largely carried out by volunteers, with the Motuora Restoration Society (MRS) established in 1995. The MRS now manages the island jointly with the Department of Conservation (DOC).

## Environment

Extensive planting of native vegetation has taken place on the island in order to restore the original forest cover. Exotic mammals never became established there. Native animals that have been introduced (or reintroduced) as part of the ecosystem restoration program include wetapunga, shore skinks, and common, Pacific and Duvaucel's geckos.

### Birds

The island supports a small breeding colony of Australasian gannets. Common diving petrel and Pycroft's petrel chicks have been translocated to the island in an effort to establish breeding colonies. Grey-faced petrels nest on the island. North Island brown kiwis chicks have been brought to the island since 1999 as part of the Department of Conservation's Operation Nest Egg, which uses predator-free islands as ‘kiwi creche’ sites before the birds are transferred to the mainland.
# 2010–11 Big 12 Conference men's basketball season

The 2010–11 Big 12 Conference men's basketball season marked the 15th season of Big 12 Conference basketball.
This was the final season for the Big 12 as a 12-team conference, as two schools departed at the end of the 2010–11 academic year. Colorado joined the Pacific-10 Conference, which became the Pac-12, while Nebraska joined the Big Ten Conference.

## Preseason
### Big 12 Coaches Poll

| Rank | Team | Votes |
| 1 | Kansas State (10) | 119 |
| 2 | Kansas (2) | 109 |
| 3 | Texas | 99 |
| 4 | Baylor | 96 |
| 5 | Missouri | 82 |
| 6 | Texas A&M | 69 |
| 7 | Texas Tech | 52 |
| 8 | Oklahoma State | 51 |
| 9 | Colorado | 46 |
| 10 | Nebraska | 31 |
| 11 | Oklahoma | 27 |
| 12 | Iowa State | 11 |

### All-Big 12 players

* Jacob Pullen, Kansas State (unanimous)
* LaceDarius Dunn, Baylor (unanimous)
* Cory Higgins, Colorado
* Marcus Morris, Kansas
* Curtis Kelly, Kansas State
Player of the Year
* Marcus Morris, Kansas
Newcomer of the Year
* Ricardo Ratliffe, Missouri
Freshman of the Year
* Josh Selby, Kansas

## Regular season
### Rankings

| AP Poll | Pre | Wk 1 | Wk 2 | Wk 3 | Wk 4 | Wk 5 | Wk 6 | Wk 7 | Wk 8 | Wk 9 | Wk 10 | Wk 11 | Wk 12 | Wk 13 | Wk 14 | Wk 15 | Wk 16 | Wk 17 | Wk 18 |
| Baylor | 16 | 17 | 12 | 11 | 10 | 9 | 15 | RV | RV | RV | RV | RV | | RV | RV | | | | |
| Colorado | RV | RV | | | | | | | | | RV | | | | | | | | RV |
| Iowa State | | | RV | RV | | | | | | | | | | | | | | | |
| Kansas | 7 | 7 | 6 | 4 | 4 | 3 | 3 | 3 | 3 | 3 | 2 | 6 | 2 | 2 | 1 | 3 | 2 | 2 | 2 |
| Kansas State | 3 | 3 | 4 | 5 | 5 | 6 | 11 | 17 | 17 | 21 | RV | | | | | | RV | 19 | 21 |
| Missouri | 15 | 15 | 11 | 9 | 15 | 13 | 9 | 10 | 9 | 15 | 13 | 11 | 14 | 19 | 20 | 20 | 22 | RV | RV |
| Nebraska | | | | | | | | | | | | | | | | | | | |
| Oklahoma | | | | | | | | | | | | | | | | | | | |
| Oklahoma State | | | | | | | RV | RV | | RV | | | | | | | | | |
| Texas | RV | RV | 20 | 19 | 25 | 22 | 18 | 13 | 12 | 12 | 10 | 7 | 3 | 3 | 3 | 5 | 7 | 10 | 8 |
| Texas A&M | | | | RV | RV | 25 | 25 | 18 | 16 | 14 | 11 | 13 | 16 | 22 | 21 | 21 | 24 | RV | 24 |
| Texas Tech | | | | | | | | | | | | | | | | | | | |

### In-season honors
#### Players of the week

Throughout the conference regular season, the Big 12 offices name a player of the week each Monday.
* Nov. 15 – Jordan Hamilton, Texas
* Nov. 22 – Jordan Hamilton, Texas
* Nov. 29 – Marcus Morris, Kansas
* Dec. 6 – Marcus Denmon, Missouri
* Dec. 13 – Marshall Moses, Oklahoma State
* Dec. 20 – Khris Middleton, Texas A&M
* Dec. 27 – Markieff Morris, Kansas
* Jan. 3 – Marcus Denmon, Missouri
* Jan. 10 – Alec Burks, Colorado
* Jan. 17 – Marcus Morris, Kansas
* Jan. 24 – Jordan Hamilton, Texas
* Jan. 31 – Mike Singletary, Texas Tech
* Feb. 7 – Jacob Pullen, Kansas State
* Feb. 14 – Marcus Morris, Kansas
* Feb. 21 – Jacob Pullen, Kansas State
* Feb. 28 – Alec Burks, Colorado
# 2010 Karshi Challenger – Doubles

Sadik Kadir and Purav Raja were the defending champions, but they lost to Murad Inoyatov and Andrey Kumantsov in the first round. Gong Maoxin and Li Zhe won the title, by defeating Divij Sharan and Vishnu Vardhan 6–3, 6–1 in the final.

## Seeds

* Sadik Kadir / Purav Raja (first round)
* Denys Molchanov / Artem Smirnov (semifinals)
* Lee Hsin-han / Yang Tsung-hua (quarterfinals)
* Andis Juška / Deniss Pavlovs (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Draw

| First round | First round | First round | First round | First round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Finals | Finals | Finals |
| 1 | S Kadir P Raja | 5 | 1 | | | | | | | | | | | | | |
| | M Inoyatov A Kumantsov | 7 | 6 | | | M Inoyatov A Kumantsov | 1 | 2 | | | | | | | | |
| | B Kavčič B Pašanski | 1 | 6$^0$ | | | M Elgin K Kravchuk | 6 | 6 | | | | | | | | |
| | M Elgin K Kravchuk | 6 | 7 | | | | | | | | M Elgin K Kravchuk | 3 | 4 | | | |
| 4 | A Juška D Pavlovs | 6 | 0 | [4] | | | | | | | M Gong Z Li | 6 | 6 | | | |
| | A Kedryuk D Matsukevich | 4 | 6 | [10] | | A Kedryuk D Matsukevich | 7 | 4 | [4] | | | | | | | |
| | M Gong Z Li | 4 | 7 | [10] | | M Gong Z Li | 6$^4$ | 6 | [10] | | | | | | | |
| | C Poch-Gradin J-M Valverde | 6 | 6$^5$ | [8] | | | | | | | | | | M Gong Z Li | 6 | 6 |
| | D Sharan V Vardhan | 7 | 6 | | | | | | | | | | | D Sharan V Vardhan | 3 | 1 |
| ALT | A Asanov S Groth | 5 | 2 | | | D Sharan V Vardhan | 7 | 6 | | | | | | | | |
| | J Minář M Semjan | 4 | 6$^4$ | | 3 | H-h Lee T-h Yang | 6$^2$ | 4 | | | | | | | | |
| 3 | H-h Lee T-h Yang | 6 | 7 | | | | | | | | D Sharan V Vardhan | 7 | 6 | | | |
| WC | S Ikramov T Ismailov | 6 | 6 | | | | | | | 2 | D Molchanov A Smirnov | 6$^1$ | 1 | | | |
| WC | B Kamiljanov N Shofayziev | 4 | 3 | | WC | S Ikramov T Ismailov | 1 | 3 | | | | | | | | |
| WC | J Kaydarov V Uzakov | 0 | r | | 2 | D Molchanov A Smirnov | 6 | 6 | | | | | | | | |
| 2 | D Molchanov A Smirnov | 6 | | | | | | | | | | | | | | |
# Charlie Sanders (actor)

Charles Henry Sanders (born August 22, 1979) is an American actor, comedian, and Writers Guild Award–winning writer best known for starring as Officer Joe Stubeck in the MTV comedy-action series Death Valley, writing on all five seasons of Key & Peele and creating the YouTube Premium series Weird City. He is currently hosting the hit podcast 'Bald Talk' on iHeartMedia with comedian and actor Brian Huskey.

## Early life

The eldest of three brothers, Sanders was born in Minneapolis, Minnesota, and grew up in Saint Paul, where he graduated from St. Paul Central High School in 1998. While in high school he participated in Central Touring Theatre Company (alongside fellow comedians Nick Swardson and Colton Dunn) and the school swim team and later performed at ComedySportz in Minneapolis.
Sanders worked at Bryant-Lake Bowl doing sound for comedy shows, while briefly attending the University of Minnesota. He then moved to New York City in 2001 where he began regularly performing improvisational comedy at the Upright Citizens Brigade Theater (UCBT), where he was a member of the improv groups "Police Chief Rumble" and "Reuben Williams". In 2004 he and his improv team "Police Chief Rumble" won "Best Sketch Group" at the Emerging Comics of New York Awards. Sanders now performs at the UCBT's Los Angeles division with his current sketch group "Shitty Jobs".

## Career

Sanders has appeared as a sketch regular on Late Night with Conan O'Brien for several years and has appeared in films such as When in Rome and Cedar Rapids. Sanders currently stars as Officer Joe Stubeck in the MTV comedy-action Death Valley and has made recurring appearances on comedy programs such as Funny or Die Presents and Childrens Hospital. For a number of years he was part of the sketch-comedy trio "The Buffoons" with comedians Bobby Moynihan and Eugene Cordero. The trio performed regularly at the Upright Citizens Brigade Theater and also at Montreal's "Just For Laughs" Comedy Festival in 2007. Sanders also performed his one-man show "Minnesota Muslim" for several years, which was praised in Time Out NY and New York Magazine.
Sanders has written for sketch-comedy programs such MTV's Human Giant and currently on the Comedy Central series Key & Peele. Sanders also wrote the Funny or Die produced short film "The Big Dog", which he starred in alongside Bob Odenkirk and Rich Sommer.
# Moritz West

Moritz West (6 August 1840 – 11 July 1904) was an Austrian businessman and librettist, writing libretti for operettas by Carl Zeller and Franz von Suppé.

## Life

West was born in Vienna, and studied law at the University of Vienna from 1858 to 1862. Meanwhile, he was interested in writing dramas, and his early work gained approval from Franz Grillparzer and Eduard von Bauernfeld.
He was appointed secretary of the Union Bank of Vienna, and from 1874 to 1878 he was a director of the Olomouc-Jägerndorf Railway. Because of ill health he discontinued his business commitments, and spent some time in Italy. Richard Genée encouraged him to take up writing.
He collaborated with Ludwig Held to write libretti for operettas by Carl Zeller, including Der Vogelhändler and The Mine Foreman. He also worked for the composers Richard Genée, Johann Brandl and Franz von Suppé.
West died in 1904, in Aigen im Mühlkreis in Upper Austria.
# ABCB4

The ATP-binding cassette 4 (ABCB4) gene encodes multidrug resistance protein 3. ABCB4 is associated with progressive familial intrahepatic cholestasis type 3 and intrahepatic cholestasis of pregnancy.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate (flippase activity). The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

## Cancer

ABCB4 gene has been observed progressively downregulated in human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, ABCB4 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.
Other conditions that have been associated with mutations in this gene include low phospholipid associated cholelithiasis syndrome, high gamma glutamyl transferase intrahepatic cholestasis of pregnancy, chronic cholangiopathy and adult biliary fibrosis.