# Luke O'Neill (scientist)

Luke Anthony John O'Neill FRS MRIA (born 17 June 1964) is an Irish biochemist. He has been a professor of biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin since 2009.

## Early life and education

O'Neill was born on 17 June 1964 in Dublin, Ireland, to Kevin O'Neill and Carmel O'Neill (née Sherry). He was educated at St Peter's School and Presentation College in Bray, County Wicklow, and went to Trinity College Dublin, where he was awarded an undergraduate degree in Natural Sciences (Biochemistry) in 1985. He completed his postgraduate study at the University of London, where he was awarded a PhD in pharmacology, for research investigating the characterisation of prostaglandin E$_2$ release induced by interleukin-1 in human synovial cells, in 1988. Following his PhD, he worked at the postdoctoral researcher at the Strangeways Research Laboratory in Cambridge funded by the Medical Research Council.

## Research

O'Neill's research investigates inflammation, a highly complex process that is provoked in the body during infection by bacteria and viruses but also in response to major trauma and injury. Inflammation restores us to health but for largely unknown reasons it can go rogue and give rise to a whole range of inflammatory diseases which remain difficult to treat.
He has worked on the innate immune system, which lies at the heart of inflammation. He has uncovered new molecules and biochemical processes that are triggered by sensors of infection and tissue injury, including the toll-like receptors and inflammasomes, and the signals they drive that stimulate inflammation, notably cytokines in the interleukin-1 family. He has made pioneering discoveries in the area of metabolic reprogramming in immunity and immunometabolism. He is using his findings to help in the effort to develop novel anti-inflammatory medicines. He has co-founded Inflazome with Matt Cooper which developed NLRP3 inhibitors and was acquired by Roche Ltd in 2020, and Sitryx with Houman Ashrafian, Johnathan Powell, Jeff Rathmell and Mike Rosenblum.
In 2023 he was appointed Chief Scientific Officer of Senda Biosciences, a company pioneering programmable medicines.
His research has been funded by the Science Foundation Ireland (SFI), the European Research Council (ERC), the Wellcome Trust and GlaxoSmithKline.

## Awards and honours

O'Neill was awarded the Royal Dublin Society & The Irish Times Robert Boyle Medal for scientific excellence in 2009, the Royal Irish Academy Gold Medal for Life Sciences in 2012 and the European Federation of Immunology Societies (EFIS) Medal in 2014. He was elected a member of the Royal Irish Academy (MRIA) in 2004 and the European Molecular Biology Organisation (EMBO) in 2005. O'Neill was elected a Fellow of the Royal Society (FRS) in 2016.
In 2019 he won the Landsteiner Award from the Austrian Academy of Sciences. In 2021 he won the UCD Biological Society George Sigerson Award for Inspiring Aspiring Scientists.
In 2022, he was made an honorary Doctor of Science by the University of Bath and was presented with an honorary lifetime membership award by the International Cytokine and Interferon Society (https://cytokinesociety.org/luke-oneill-2022/?amp=1).
In 2023 he was appointed to the governing body of the European Research Council, the European Union's premier funder of fundamental research (https://ireland.representation.ec.europa.eu/news-and-events/news/professor-luke-oneill-appointed-governing-body-european-research-council-2022-12-07_en) and was awarded an honorary Doctor of Science degree by UMass Chan Medical School. https://www.telegram.com/story/news/2023/06/04/class-of-2023-of-umass-chan-medical-school/70286515007/
In 2024 he was made Honorary Fellow of the British Pharmacological Society.

## Public engagement

O'Neill has a weekly science slot with Pat Kenny on the Irish national radio station Newstalk and a Podcast entitled 'Show Me the Science'.
In 2018, he published Humanology: A Scientist's Guide to our Amazing Existence with Gill publishers. In 2019, he published a science book for children, The Great Irish Science Book with Gill. He has a weekly column on science in the Sunday Independent and wrote extensively concerning the COVID-19 pandemic in the Republic of Ireland. He contracted COVID-19 himself in December 2021, and experienced symptoms.
In 2020 he won the An Post Irish Book of the Year Award for best popular non-fiction book for Never Mind the B*ll*cks, Here's the Science, published by Gill, which was a best seller. He also won the Science Foundation Ireland Science Communicator of the Year Award, for his media work on COVID19.
In 2021 he published Keep Calm and Trust the Science: A Remarkable Year in the Life of an Immunologist, which is his diary covering the COVID-19 pandemic.
In 2023 he published 'To Boldly Go Where No Book has Gone Before', with Penguin Random House.

## Personal life

O'Neill married Margaret Worrall in 1993. They have two sons.