# List of United States senators from South Carolina

South Carolina ratified the United States Constitution on May 23, 1788. Its Senate seats were declared vacant in July 1861 owing to its secession from the Union. They were again filled from July 1868. The state's current U.S. senators are Republicans Lindsey Graham, serving since 2003, and Tim Scott, serving since 2013. Strom Thurmond was the state's longest-serving senator (1954–1956, 1956–2003).

## List of senators

| Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in 2002, 2008, 2014, and 2020. The next election will be in 2026. | Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in 2002, 2008, 2014, and 2020. The next election will be in 2026. | Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in 2002, 2008, 2014, and 2020. The next election will be in 2026. | Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in 2002, 2008, 2014, and 2020. The next election will be in 2026. | Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in 2002, 2008, 2014, and 2020. The next election will be in 2026. | Class 2Class 2 U.S. senators belong to the electoral cycle that has recently been contested in 2002, 2008, 2014, and 2020. The next election will be in 2026. | C | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in 2010, 2014 (special election), 2016, and 2022. The next election will be in 2028. | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in 2010, 2014 (special election), 2016, and 2022. The next election will be in 2028. | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in 2010, 2014 (special election), 2016, and 2022. The next election will be in 2028. | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in 2010, 2014 (special election), 2016, and 2022. The next election will be in 2028. | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in 2010, 2014 (special election), 2016, and 2022. The next election will be in 2028. | Class 3Class 3 U.S. senators belong to the electoral cycle that has recently been contested in 2010, 2014 (special election), 2016, and 2022. The next election will be in 2028. |
| # | Senator | Party | Dates in office | Electoral history | T | C | T | Electoral history | Dates in office | Party | Senator | # |
| 1 | Pierce Butler | Pro-Admin. | Mar 4, 1789 – Oct 25, 1796 | Elected in 1789. | 1 | 1st | 1 | Elected in 1789.Retired. | Mar 4, 1789 – Mar 3, 1795 | Pro-Admin. | Ralph Izard | 1 |
| 1 | Pierce Butler | Anti- Admin. | Mar 4, 1789 – Oct 25, 1796 | Elected in 1789. | 1 | 2nd | 1 | Elected in 1789.Retired. | Mar 4, 1789 – Mar 3, 1795 | Pro-Admin. | Ralph Izard | 1 |
| 1 | Pierce Butler | Anti- Admin. | Mar 4, 1789 – Oct 25, 1796 | Re-elected in 1793.Resigned. | 2 | 3rd | 1 | Elected in 1789.Retired. | Mar 4, 1789 – Mar 3, 1795 | Pro-Admin. | Ralph Izard | 1 |
| 1 | Pierce Butler | Democratic- Republican | Mar 4, 1789 – Oct 25, 1796 | Re-elected in 1793.Resigned. | 2 | 4th | 2 | Elected in 1794 or 1795.Lost re-election. | Mar 4, 1795 – Mar 3, 1801 | Federalist | Jacob Read | 2 |
| Vacant | Vacant | Vacant | Oct 25, 1796 – Dec 8, 1796 | | 2 | 4th | 2 | Elected in 1794 or 1795.Lost re-election. | Mar 4, 1795 – Mar 3, 1801 | Federalist | Jacob Read | 2 |
| 2 | John Hunter | Democratic- Republican | Dec 8, 1796 – Nov 26, 1798 | Elected to finish Butler's term.Resigned. | 2 | 4th | 2 | Elected in 1794 or 1795.Lost re-election. | Mar 4, 1795 – Mar 3, 1801 | Federalist | Jacob Read | 2 |
| 2 | John Hunter | Democratic- Republican | Dec 8, 1796 – Nov 26, 1798 | Elected to finish Butler's term.Resigned. | 2 | 5th | 2 | Elected in 1794 or 1795.Lost re-election. | Mar 4, 1795 – Mar 3, 1801 | Federalist | Jacob Read | 2 |
| 3 | Charles Pinckney | Democratic- Republican | Dec 6, 1798 – Jun 6, 1801 | Elected to finish Butler's term. | 2 | 5th | 2 | Elected in 1794 or 1795.Lost re-election. | Mar 4, 1795 – Mar 3, 1801 | Federalist | Jacob Read | 2 |
| 3 | Charles Pinckney | Democratic- Republican | Dec 6, 1798 – Jun 6, 1801 | Re-elected in 1799.Resigned to become U.S. Minister to Spain. | 3 | 6th | 2 | Elected in 1794 or 1795.Lost re-election. | Mar 4, 1795 – Mar 3, 1801 | Federalist | Jacob Read | 2 |
| 3 | Charles Pinckney | Democratic- Republican | Dec 6, 1798 – Jun 6, 1801 | Re-elected in 1799.Resigned to become U.S. Minister to Spain. | 3 | 7th | 3 | Elected in 1800.Died. | Mar 4, 1801 – Oct 26, 1802 | Democratic- Republican | John E. Colhoun | 3 |
| Vacant | Vacant | Vacant | Jun 6, 1801 – Dec 15, 1801 | | 3 | 7th | 3 | Elected in 1800.Died. | Mar 4, 1801 – Oct 26, 1802 | Democratic- Republican | John E. Colhoun | 3 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Elected in 1801 to finish Pinckney's term. | 3 | 7th | 3 | Elected in 1800.Died. | Mar 4, 1801 – Oct 26, 1802 | Democratic- Republican | John E. Colhoun | 3 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Elected in 1801 to finish Pinckney's term. | 3 | 7th | 3 | | Oct 26, 1802 – Nov 4, 1802 | Vacant | Vacant | Vacant |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Elected in 1801 to finish Pinckney's term. | 3 | 7th | 3 | Elected to finish Colhoun's term.Resigned. | Nov 4, 1802 – Nov 21, 1804 | Democratic- Republican | Pierce Butler | 4 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Elected in 1801 to finish Pinckney's term. | 3 | 8th | 3 | Elected to finish Colhoun's term.Resigned. | Nov 4, 1802 – Nov 21, 1804 | Democratic- Republican | Pierce Butler | 4 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Elected in 1801 to finish Pinckney's term. | 3 | 8th | 3 | | Nov 21, 1804 – Dec 6, 1804 | Vacant | Vacant | Vacant |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Elected in 1801 to finish Pinckney's term. | 3 | 8th | 3 | Elected to finish Colhoun's term. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Re-elected in 1804.Resigned. | 4 | 9th | 3 | Elected to finish Colhoun's term. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Re-elected in 1804.Resigned. | 4 | 10th | 4 | Re-elected in 1806. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 4 | Thomas Sumter | Democratic- Republican | Dec 15, 1801 – Dec 16, 1810 | Re-elected in 1804.Resigned. | 4 | 11th | 4 | Re-elected in 1806. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| Vacant | Vacant | Vacant | Dec 16, 1810 – Dec 31, 1810 | | 4 | 11th | 4 | Re-elected in 1806. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 5 | John Taylor | Democratic- Republican | Dec 31, 1810 – Nov 1816 | Elected to finish Sumter's term. | 4 | 11th | 4 | Re-elected in 1806. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 5 | John Taylor | Democratic- Republican | Dec 31, 1810 – Nov 1816 | Re-elected in 1810.Resigned. | 5 | 12th | 4 | Re-elected in 1806. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 5 | John Taylor | Democratic- Republican | Dec 31, 1810 – Nov 1816 | Re-elected in 1810.Resigned. | 5 | 13th | 5 | Re-elected in 1812. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 5 | John Taylor | Democratic- Republican | Dec 31, 1810 – Nov 1816 | Re-elected in 1810.Resigned. | 5 | 14th | 5 | Re-elected in 1812. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| Vacant | Vacant | Vacant | Nov 1816 – Dec 4, 1816 | | 5 | 14th | 5 | Re-elected in 1812. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 6 | William Smith | Democratic- Republican | Dec 4, 1816 – Mar 3, 1823 | Elected to finish Taylor's term. | 5 | 14th | 5 | Re-elected in 1812. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 6 | William Smith | Democratic- Republican | Dec 4, 1816 – Mar 3, 1823 | Re-elected in 1816.Lost re-election. | 6 | 15th | 5 | Re-elected in 1812. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 6 | William Smith | Democratic- Republican | Dec 4, 1816 – Mar 3, 1823 | Re-elected in 1816.Lost re-election. | 6 | 16th | 6 | Re-elected in 1818. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 6 | William Smith | Democratic- Republican | Dec 4, 1816 – Mar 3, 1823 | Re-elected in 1816.Lost re-election. | 6 | 17th | 6 | Re-elected in 1818. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 7 | Robert Y. Hayne | Democratic- Republican | Mar 4, 1823 – Dec 13, 1832 | Elected in 1822. | 7 | 18th | 6 | Re-elected in 1818. | Dec 6, 1804 – Feb 26, 1826 | Democratic- Republican | John Gaillard | 5 |
| 7 | Robert Y. Hayne | Jacksonian | Mar 4, 1823 – Dec 13, 1832 | Elected in 1822. | 7 | 19th | 7 | Re-elected in 1824.Died. | Dec 6, 1804 – Feb 26, 1826 | Jacksonian | John Gaillard | 5 |
| 7 | Robert Y. Hayne | Jacksonian | Mar 4, 1823 – Dec 13, 1832 | Elected in 1822. | 7 | 19th | 7 | | Feb 26, 1826 – Mar 8, 1826 | Vacant | Vacant | Vacant |
| 7 | Robert Y. Hayne | Jacksonian | Mar 4, 1823 – Dec 13, 1832 | Elected in 1822. | 7 | 19th | 7 | Appointed to continue Gaillard's term. | Mar 8, 1826 – Nov 29, 1826 | Jacksonian | William Harper | 6 |
| 7 | Robert Y. Hayne | Jacksonian | Mar 4, 1823 – Dec 13, 1832 | Elected in 1822. | 7 | 19th | 7 | Elected to finish Gaillard's term.Lost re-election. | Nov 29, 1826 – Mar 3, 1831 | Jacksonian | William Smith | 7 |
| 7 | Robert Y. Hayne | Jacksonian | Mar 4, 1823 – Dec 13, 1832 | Elected in 1822. | 7 | 20th | 7 | Elected to finish Gaillard's term.Lost re-election. | Nov 29, 1826 – Mar 3, 1831 | Jacksonian | William Smith | 7 |
| 7 | Robert Y. Hayne | Jacksonian | Mar 4, 1823 – Dec 13, 1832 | Re-elected in 1828.Resigned to become South Carolina Governor. | 8 | 21st | 7 | Elected to finish Gaillard's term.Lost re-election. | Nov 29, 1826 – Mar 3, 1831 | Jacksonian | William Smith | 7 |
| 7 | Robert Y. Hayne | Nullifier | Mar 4, 1823 – Dec 13, 1832 | Re-elected in 1828.Resigned to become South Carolina Governor. | 8 | 22nd | 8 | Elected in 1830.Resigned due to ill health. | Mar 4, 1831 – Mar 3, 1833 | Nullifier | Stephen Decatur Miller | 8 |
| Vacant | Vacant | Vacant | Dec 13, 1832 – Dec 29, 1832 | | 8 | 22nd | 8 | Elected in 1830.Resigned due to ill health. | Mar 4, 1831 – Mar 3, 1833 | Nullifier | Stephen Decatur Miller | 8 |
| 8 | John C. Calhoun | Nullifier | Dec 29, 1832 – Mar 3, 1843 | Elected to finish Hayne's term. | 8 | 22nd | 8 | Elected in 1830.Resigned due to ill health. | Mar 4, 1831 – Mar 3, 1833 | Nullifier | Stephen Decatur Miller | 8 |
| 8 | John C. Calhoun | Nullifier | Dec 29, 1832 – Mar 3, 1843 | Elected to finish Hayne's term. | 8 | 23rd | 8 | | Mar 3, 1833 – Nov 26, 1833 | Vacant | Vacant | Vacant |
| 8 | John C. Calhoun | Nullifier | Dec 29, 1832 – Mar 3, 1843 | Elected to finish Hayne's term. | 8 | 23rd | 8 | Elected to finish Miller's term. | Nov 26, 1833 – Nov 29, 1842 | Nullifier | William C. Preston | 9 |
| 8 | John C. Calhoun | Nullifier | Dec 29, 1832 – Mar 3, 1843 | Re-elected in 1834. | 9 | 24th | 8 | Elected to finish Miller's term. | Nov 26, 1833 – Nov 29, 1842 | Nullifier | William C. Preston | 9 |
| 8 | John C. Calhoun | Democratic | Dec 29, 1832 – Mar 3, 1843 | Re-elected in 1834. | 9 | 25th | 9 | Re-elected in 1837.Resigned. | Nov 26, 1833 – Nov 29, 1842 | Whig | William C. Preston | 9 |
| 8 | John C. Calhoun | Democratic | Dec 29, 1832 – Mar 3, 1843 | Re-elected in 1834. | 9 | 26th | 9 | Re-elected in 1837.Resigned. | Nov 26, 1833 – Nov 29, 1842 | Whig | William C. Preston | 9 |
| 8 | John C. Calhoun | Democratic | Dec 29, 1832 – Mar 3, 1843 | Re-elected in 1840.Resigned. | 10 | 27th | 9 | Re-elected in 1837.Resigned. | Nov 26, 1833 – Nov 29, 1842 | Whig | William C. Preston | 9 |
| 8 | John C. Calhoun | Democratic | Dec 29, 1832 – Mar 3, 1843 | Re-elected in 1840.Resigned. | 10 | 27th | 9 | | Nov 29, 1842 – Dec 23, 1842 | Vacant | Vacant | Vacant |
| 8 | John C. Calhoun | Democratic | Dec 29, 1832 – Mar 3, 1843 | Re-elected in 1840.Resigned. | 10 | 27th | 9 | Elected to finish Preston's term. | Dec 23, 1842 – Aug 17, 1846 | Democratic | George McDuffie | 10 |
| 9 | Daniel Elliott Huger | Democratic | Mar 4, 1843 – Mar 3, 1845 | Elected to finish Calhoun's term.Resigned. | 10 | 28th | 10 | Re-elected in 1842 or 1843. | Dec 23, 1842 – Aug 17, 1846 | Democratic | George McDuffie | 10 |
| Vacant | Vacant | Vacant | Mar 3, 1845 – Nov 26, 1845 | | 10 | 29th | 10 | Re-elected in 1842 or 1843. | Dec 23, 1842 – Aug 17, 1846 | Democratic | George McDuffie | 10 |
| 10 | John C. Calhoun | Democratic | Nov 26, 1845 – Mar 31, 1850 | Re-elected to finish his own term. | 10 | 29th | 10 | Re-elected in 1842 or 1843. | Dec 23, 1842 – Aug 17, 1846 | Democratic | George McDuffie | 10 |
| 10 | John C. Calhoun | Democratic | Nov 26, 1845 – Mar 31, 1850 | Re-elected to finish his own term. | 10 | 29th | 10 | | Aug 17, 1846 – Dec 4, 1846 | Vacant | Vacant | Vacant |
| 10 | John C. Calhoun | Democratic | Nov 26, 1845 – Mar 31, 1850 | Re-elected to finish his own term. | 10 | 29th | 10 | Appointed to continue McDuffie's term.Elected to finish McDuffie's term. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 10 | John C. Calhoun | Democratic | Nov 26, 1845 – Mar 31, 1850 | Re-elected in 1846.Died. | 11 | 30th | 10 | Appointed to continue McDuffie's term.Elected to finish McDuffie's term. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 10 | John C. Calhoun | Democratic | Nov 26, 1845 – Mar 31, 1850 | Re-elected in 1846.Died. | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| Vacant | Vacant | Vacant | Mar 31, 1850 – Apr 11, 1850 | | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 11 | Franklin H. Elmore | Democratic | Apr 11, 1850 – May 29, 1850 | Appointed to continue Calhoun's term.Died. | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| Vacant | Vacant | Vacant | May 29, 1850 – Jun 4, 1850 | | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 12 | Robert W. Barnwell | Democratic | Jun 4, 1850 – Dec 8, 1850 | Appointed to continue Calhoun's term.Retired when his successor was elected. | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| Vacant | Vacant | Vacant | Dec 8, 1850 – Dec 18, 1850 | | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 13 | Robert Rhett | Democratic | Dec 18, 1850 – May 7, 1852 | Elected to finish Calhoun's term.Resigned. | 11 | 31st | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 13 | Robert Rhett | Democratic | Dec 18, 1850 – May 7, 1852 | Elected to finish Calhoun's term.Resigned. | 11 | 32nd | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| Vacant | Vacant | Vacant | May 7, 1852 – May 10, 1852 | | 11 | 32nd | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 14 | William F. De Saussure | Democratic | May 10, 1852 – Mar 3, 1853 | Appointed to continue Calhoun's term.Elected Nov 29, 1852 to finish Calhoun's term. | 11 | 32nd | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 15 | Josiah Evans | Democratic | Mar 4, 1853 – May 6, 1858 | Elected in 1852 or 1853.Died. | 12 | 33rd | 11 | Re-elected in 1848. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 15 | Josiah Evans | Democratic | Mar 4, 1853 – May 6, 1858 | Elected in 1852 or 1853.Died. | 12 | 34th | 12 | Re-elected in 1854.Died. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 15 | Josiah Evans | Democratic | Mar 4, 1853 – May 6, 1858 | Elected in 1852 or 1853.Died. | 12 | 35th | 12 | Re-elected in 1854.Died. | Dec 4, 1846 – May 25, 1857 | Democratic | Andrew Butler | 11 |
| 15 | Josiah Evans | Democratic | Mar 4, 1853 – May 6, 1858 | Elected in 1852 or 1853.Died. | 12 | 35th | 12 | | May 25, 1857 – Dec 7, 1857 | Vacant | Vacant | Vacant |
| 15 | Josiah Evans | Democratic | Mar 4, 1853 – May 6, 1858 | Elected in 1852 or 1853.Died. | 12 | 35th | 12 | Elected to finish Butler's term.Withdrew. | Dec 7, 1857 – Nov 11, 1860 | Democratic | James H. Hammond | 12 |
| Vacant | Vacant | Vacant | May 6, 1858 – May 11, 1858 | | 12 | 35th | 12 | Elected to finish Butler's term.Withdrew. | Dec 7, 1857 – Nov 11, 1860 | Democratic | James H. Hammond | 12 |
| 16 | Arthur P. Hayne | Democratic | May 11, 1858 – Dec 2, 1858 | Appointed to continue Evans' term.Retired when his successor was elected. | 12 | 35th | 12 | Elected to finish Butler's term.Withdrew. | Dec 7, 1857 – Nov 11, 1860 | Democratic | James H. Hammond | 12 |
| 17 | James Chesnut Jr. | Democratic | Dec 3, 1858 – Nov 10, 1860 | Elected to finish Evans' term. | 12 | 35th | 12 | Elected to finish Butler's term.Withdrew. | Dec 7, 1857 – Nov 11, 1860 | Democratic | James H. Hammond | 12 |
| 17 | James Chesnut Jr. | Democratic | Dec 3, 1858 – Nov 10, 1860 | Re-elected in 1858.Withdrew and was later expelled for his support of the Confederacy. | 13 | 36th | 12 | Elected to finish Butler's term.Withdrew. | Dec 7, 1857 – Nov 11, 1860 | Democratic | James H. Hammond | 12 |
| Vacant | Vacant | Vacant | Nov 10, 1860 – Jul 15, 1868 | Civil War and Reconstruction. | 13 | 36th | 12 | Elected to finish Butler's term.Withdrew. | Dec 7, 1857 – Nov 11, 1860 | Democratic | James H. Hammond | 12 |
| Vacant | Vacant | Vacant | Nov 10, 1860 – Jul 15, 1868 | Civil War and Reconstruction. | 13 | 36th | 12 | Civil War and Reconstruction. | Nov 11, 1860 – Jul 16, 1868 | Vacant | Vacant | Vacant |
| Vacant | Vacant | Vacant | Nov 10, 1860 – Jul 15, 1868 | Civil War and Reconstruction. | 13 | 37th | 13 | Civil War and Reconstruction. | Nov 11, 1860 – Jul 16, 1868 | Vacant | Vacant | Vacant |
| Vacant | Vacant | Vacant | Nov 10, 1860 – Jul 15, 1868 | Civil War and Reconstruction. | 13 | 38th | 13 | Civil War and Reconstruction. | Nov 11, 1860 – Jul 16, 1868 | Vacant | Vacant | Vacant |
| Vacant | Vacant | Vacant | Nov 10, 1860 – Jul 15, 1868 | Civil War and Reconstruction. | 14 | 39th | 13 | Civil War and Reconstruction. | Nov 11, 1860 – Jul 16, 1868 | Vacant | Vacant | Vacant |
| Vacant | Vacant | Vacant | Nov 10, 1860 – Jul 15, 1868 | Civil War and Reconstruction. | 14 | 40th | 14 | Civil War and Reconstruction. | Nov 11, 1860 – Jul 16, 1868 | Vacant | Vacant | Vacant |
| 18 | Thomas J. Robertson | Republican | Jul 15, 1868 – Mar 3, 1877 | Elected to finish the vacant term. | 14 | 40th | 14 | Civil War and Reconstruction. | Nov 11, 1860 – Jul 16, 1868 | Vacant | Vacant | Vacant |
| 18 | Thomas J. Robertson | Republican | Jul 15, 1868 – Mar 3, 1877 | Elected to finish the vacant term. | 14 | 40th | 14 | Elected to finish the vacant term. | Jul 16, 1868 – Mar 3, 1873 | Republican | Frederick A. Sawyer | 13 |
| 18 | Thomas J. Robertson | Republican | Jul 15, 1868 – Mar 3, 1877 | Elected to finish the vacant term. | 14 | 41st | 14 | Elected to finish the vacant term. | Jul 16, 1868 – Mar 3, 1873 | Republican | Frederick A. Sawyer | 13 |
| 18 | Thomas J. Robertson | Republican | Jul 15, 1868 – Mar 3, 1877 | Re-elected in 1870.Retired. | 15 | 42nd | 14 | Elected to finish the vacant term. | Jul 16, 1868 – Mar 3, 1873 | Republican | Frederick A. Sawyer | 13 |
| 18 | Thomas J. Robertson | Republican | Jul 15, 1868 – Mar 3, 1877 | Re-elected in 1870.Retired. | 15 | 43rd | 15 | Elected in 1872 or 1873. | Mar 4, 1873 – Mar 3, 1879 | Republican | John J. Patterson | 14 |
| 18 | Thomas J. Robertson | Republican | Jul 15, 1868 – Mar 3, 1877 | Re-elected in 1870.Retired. | 15 | 44th | 15 | Elected in 1872 or 1873. | Mar 4, 1873 – Mar 3, 1879 | Republican | John J. Patterson | 14 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Elected in 1876. | 16 | 45th | 15 | Elected in 1872 or 1873. | Mar 4, 1873 – Mar 3, 1879 | Republican | John J. Patterson | 14 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Elected in 1876. | 16 | 46th | 16 | Elected in 1878. | Mar 4, 1879 – Mar 3, 1891 | Democratic | Wade Hampton III | 15 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Elected in 1876. | 16 | 47th | 16 | Elected in 1878. | Mar 4, 1879 – Mar 3, 1891 | Democratic | Wade Hampton III | 15 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Re-elected in 1882. | 17 | 48th | 16 | Elected in 1878. | Mar 4, 1879 – Mar 3, 1891 | Democratic | Wade Hampton III | 15 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Re-elected in 1882. | 17 | 49th | 17 | Re-elected in 1884.Lost re-election. | Mar 4, 1879 – Mar 3, 1891 | Democratic | Wade Hampton III | 15 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Re-elected in 1882. | 17 | 50th | 17 | Re-elected in 1884.Lost re-election. | Mar 4, 1879 – Mar 3, 1891 | Democratic | Wade Hampton III | 15 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Re-elected in 1888.Lost renomination. | 18 | 51st | 17 | Re-elected in 1884.Lost re-election. | Mar 4, 1879 – Mar 3, 1891 | Democratic | Wade Hampton III | 15 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Re-elected in 1888.Lost renomination. | 18 | 52nd | 18 | Elected in 1890.Retired. | Mar 4, 1891 – Mar 3, 1897 | Democratic | John L. M. Irby | 16 |
| 19 | Matthew Butler | Democratic | Mar 4, 1877 – Mar 3, 1895 | Re-elected in 1888.Lost renomination. | 18 | 53rd | 18 | Elected in 1890.Retired. | Mar 4, 1891 – Mar 3, 1897 | Democratic | John L. M. Irby | 16 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Elected in 1894. | 19 | 54th | 18 | Elected in 1890.Retired. | Mar 4, 1891 – Mar 3, 1897 | Democratic | John L. M. Irby | 16 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Elected in 1894. | 19 | 55th | 19 | Elected in 1897.Died. | Mar 4, 1897 – May 20, 1897 | Democratic | Joseph Earle | 17 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Elected in 1894. | 19 | 55th | 19 | | May 20, 1897 – May 27, 1897 | Vacant | Vacant | Vacant |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Elected in 1894. | 19 | 55th | 19 | Appointed to continue Earle's term.Elected in 1898 to finish Earle's term.Retired. | May 27, 1897 – Mar 3, 1903 | Democratic | John McLaurin | 18 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Elected in 1894. | 19 | 56th | 19 | Appointed to continue Earle's term.Elected in 1898 to finish Earle's term.Retired. | May 27, 1897 – Mar 3, 1903 | Democratic | John McLaurin | 18 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1901. | 20 | 57th | 19 | Appointed to continue Earle's term.Elected in 1898 to finish Earle's term.Retired. | May 27, 1897 – Mar 3, 1903 | Democratic | John McLaurin | 18 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1901. | 20 | 58th | 20 | Elected in 1903.Died. | Mar 4, 1903 – Feb 20, 1908 | Democratic | Asbury Latimer | 19 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1901. | 20 | 59th | 20 | Elected in 1903.Died. | Mar 4, 1903 – Feb 20, 1908 | Democratic | Asbury Latimer | 19 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1907. | 21 | 60th | 20 | Elected in 1903.Died. | Mar 4, 1903 – Feb 20, 1908 | Democratic | Asbury Latimer | 19 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1907. | 21 | 60th | 20 | | Feb 20, 1908 – Mar 6, 1908 | Vacant | Vacant | Vacant |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1907. | 21 | 60th | 20 | Elected in 1908 to finish Latimer's term.Retired. | Mar 6, 1908 – Mar 3, 1909 | Democratic | Frank B. Gary | 20 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1907. | 21 | 61st | 21 | Elected in 1909. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1907. | 21 | 62nd | 21 | Elected in 1909. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1913.Died. | 22 | 63rd | 21 | Elected in 1909. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1913.Died. | 22 | 64th | 22 | Re-elected in 1914. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 20 | Benjamin Tillman | Democratic | Mar 4, 1895 – Jul 3, 1918 | Re-elected in 1913.Died. | 22 | 65th | 22 | Re-elected in 1914. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| Vacant | Vacant | Vacant | Jul 3, 1918 – Jul 6, 1918 | | 22 | 65th | 22 | Re-elected in 1914. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 21 | Christie Benet | Democratic | Jul 6, 1918 – Nov 5, 1918 | Appointed to continue Tillman's term.Lost election to finish Tillman's term. | 22 | 65th | 22 | Re-elected in 1914. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 22 | William P. Pollock | Democratic | Nov 6, 1918 – Mar 3, 1919 | Elected to finish Tillman's term. Retired. | 22 | 65th | 22 | Re-elected in 1914. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 23 | Nathaniel Dial | Democratic | Mar 4, 1919 – Mar 3, 1925 | Elected in 1918.Lost renomination. | 23 | 66th | 22 | Re-elected in 1914. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 23 | Nathaniel Dial | Democratic | Mar 4, 1919 – Mar 3, 1925 | Elected in 1918.Lost renomination. | 23 | 67th | 23 | Re-elected in 1920. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 23 | Nathaniel Dial | Democratic | Mar 4, 1919 – Mar 3, 1925 | Elected in 1918.Lost renomination. | 23 | 68th | 23 | Re-elected in 1920. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 24 | Cole L. Blease | Democratic | Mar 4, 1925 – Mar 3, 1931 | Elected in 1924.Lost renomination. | 24 | 69th | 23 | Re-elected in 1920. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 24 | Cole L. Blease | Democratic | Mar 4, 1925 – Mar 3, 1931 | Elected in 1924.Lost renomination. | 24 | 70th | 24 | Re-elected in 1926. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 24 | Cole L. Blease | Democratic | Mar 4, 1925 – Mar 3, 1931 | Elected in 1924.Lost renomination. | 24 | 71st | 24 | Re-elected in 1926. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 25 | James F. Byrnes | Democratic | Mar 4, 1931 – Jul 8, 1941 | Elected in 1930. | 25 | 72nd | 24 | Re-elected in 1926. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 25 | James F. Byrnes | Democratic | Mar 4, 1931 – Jul 8, 1941 | Elected in 1930. | 25 | 73rd | 25 | Re-elected in 1932. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 25 | James F. Byrnes | Democratic | Mar 4, 1931 – Jul 8, 1941 | Elected in 1930. | 25 | 74th | 25 | Re-elected in 1932. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 25 | James F. Byrnes | Democratic | Mar 4, 1931 – Jul 8, 1941 | Re-elected in 1936.Resigned to become a Justice of the U.S. Supreme Court. | 26 | 75th | 25 | Re-elected in 1932. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 25 | James F. Byrnes | Democratic | Mar 4, 1931 – Jul 8, 1941 | Re-elected in 1936.Resigned to become a Justice of the U.S. Supreme Court. | 26 | 76th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 25 | James F. Byrnes | Democratic | Mar 4, 1931 – Jul 8, 1941 | Re-elected in 1936.Resigned to become a Justice of the U.S. Supreme Court. | 26 | 77th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| Vacant | Vacant | Vacant | Jul 8, 1941 – Jul 22, 1941 | | 26 | 77th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 26 | Alva Lumpkin | Democratic | Jul 22, 1941 – Aug 1, 1941 | Appointed to continue Byrnes's term.Died. | 26 | 77th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 27 | Roger Peace | Democratic | Aug 5, 1941 – Nov 4, 1941 | Appointed to continue Byrnes's term.Retired when successor elected. | 26 | 77th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Elected to finish Byrnes's term. | 26 | 77th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1942. | 27 | 78th | 26 | Re-elected in 1938.Lost renomination before dying. | Mar 4, 1909 – Nov 17, 1944 | Democratic | Ellison D. Smith | 21 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1942. | 27 | 78th | 26 | | Nov 17, 1944 – Nov 20, 1944 | Vacant | Vacant | Vacant |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1942. | 27 | 78th | 26 | Appointed to finish Smith's term.Retired when successor was elected to the next full term. | Nov 20, 1944 – Jan 3, 1945 | Democratic | Wilton E. Hall | 22 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1942. | 27 | 79th | 27 | Elected in 1944. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1942. | 27 | 80th | 27 | Elected in 1944. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1948.Died. | 28 | 81st | 27 | Elected in 1944. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1948.Died. | 28 | 82nd | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 28 | Burnet R. Maybank | Democratic | Nov 5, 1941 – Sep 1, 1954 | Re-elected in 1948.Died. | 28 | 83rd | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| Vacant | Vacant | Vacant | Sep 1, 1954 – Sep 6, 1954 | | 28 | 83rd | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 29 | Charles E. Daniel | Democratic | Sep 6, 1954 – Dec 23, 1954 | Appointed to finish Maybank's term.Resigned early to give successor preferential seniority. | 28 | 83rd | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 30 | Strom Thurmond | Democratic | Dec 24, 1954 – Apr 4, 1956 | Appointed to finish Maybank's term, having been elected to the next term. | 28 | 83rd | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 30 | Strom Thurmond | Democratic | Dec 24, 1954 – Apr 4, 1956 | Elected in 1954.Resigned. | 29 | 84th | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 31 | Thomas A. Wofford | Democratic | Apr 5, 1956 – Nov 6, 1956 | Appointed to continue Thurmond's term.Retired. | 29 | 84th | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Democratic | Nov 7, 1956 – Jan 3, 2003 | Elected in 1956 to finish his own term. | 29 | 84th | 28 | Re-elected in 1950. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Democratic | Nov 7, 1956 – Jan 3, 2003 | Elected in 1956 to finish his own term. | 29 | 85th | 29 | Re-elected in 1956. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Democratic | Nov 7, 1956 – Jan 3, 2003 | Elected in 1956 to finish his own term. | 29 | 86th | 29 | Re-elected in 1956. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Democratic | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 87th | 29 | Re-elected in 1956. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Democratic | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 88th | 30 | Re-elected in 1962.Died. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 88th | 30 | Re-elected in 1962.Died. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 89th | 30 | Re-elected in 1962.Died. | Jan 3, 1945 – Apr 18, 1965 | Democratic | Olin D. Johnston | 23 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 89th | 30 | | Apr 18, 1965 – Apr 22, 1965 | Vacant | Vacant | Vacant |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 89th | 30 | Appointed to continue Johnston's term.Lost nomination to finish Johnston's term. | Apr 22, 1965 – Nov 8, 1966 | Democratic | Donald S. Russell | 24 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1960.Changed party on Sep 16, 1964. | 30 | 89th | 30 | Elected to finish Johnston's term. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1966. | 31 | 90th | 30 | Elected to finish Johnston's term. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1966. | 31 | 91st | 31 | Re-elected in 1968. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1966. | 31 | 92nd | 31 | Re-elected in 1968. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1972. | 32 | 93rd | 31 | Re-elected in 1968. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1972. | 32 | 94th | 32 | Re-elected in 1974. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1972. | 32 | 95th | 32 | Re-elected in 1974. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1978. | 33 | 96th | 32 | Re-elected in 1974. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1978. | 33 | 97th | 33 | Re-elected in 1980. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1978. | 33 | 98th | 33 | Re-elected in 1980. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1984. | 34 | 99th | 33 | Re-elected in 1980. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1984. | 34 | 100th | 34 | Re-elected in 1986. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1984. | 34 | 101st | 34 | Re-elected in 1986. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1990. | 35 | 102nd | 34 | Re-elected in 1986. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1990. | 35 | 103rd | 35 | Re-elected in 1992. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1990. | 35 | 104th | 35 | Re-elected in 1992. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1996.Retired. | 36 | 105th | 35 | Re-elected in 1992. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1996.Retired. | 36 | 106th | 36 | Re-elected in 1998.Retired. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 32 | Strom Thurmond | Republican | Nov 7, 1956 – Jan 3, 2003 | Re-elected in 1996.Retired. | 36 | 107th | 36 | Re-elected in 1998.Retired. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Elected in 2002. | 37 | 108th | 36 | Re-elected in 1998.Retired. | Nov 9, 1966 – Jan 3, 2005 | Democratic | Fritz Hollings | 25 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Elected in 2002. | 37 | 109th | 37 | Elected in 2004. | Jan 3, 2005 – Jan 2, 2013 | Republican | Jim DeMint | 26 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Elected in 2002. | 37 | 110th | 37 | Elected in 2004. | Jan 3, 2005 – Jan 2, 2013 | Republican | Jim DeMint | 26 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2008. | 38 | 111th | 37 | Elected in 2004. | Jan 3, 2005 – Jan 2, 2013 | Republican | Jim DeMint | 26 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2008. | 38 | 112th | 38 | Re-elected in 2010.Resigned. | Jan 3, 2005 – Jan 2, 2013 | Republican | Jim DeMint | 26 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2008. | 38 | 112th | 38 | Appointed to continue DeMint's term.Elected in 2014 to finish DeMint's term. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2008. | 38 | 113th | 38 | Appointed to continue DeMint's term.Elected in 2014 to finish DeMint's term. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2014. | 39 | 114th | 38 | Appointed to continue DeMint's term.Elected in 2014 to finish DeMint's term. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2014. | 39 | 115th | 39 | Re-elected in 2016. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2014. | 39 | 116th | 39 | Re-elected in 2016. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2020. | 40 | 117th | 39 | Re-elected in 2016. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2020. | 40 | 118th | 40 | Re-elected in 2022. Retiring at the end of the term. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| 33 | Lindsey Graham | Republican | Jan 3, 2003 – present | Re-elected in 2020. | 40 | 119th | 40 | Re-elected in 2022. Retiring at the end of the term. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| To be determined in the 2026 election. | To be determined in the 2026 election. | To be determined in the 2026 election. | To be determined in the 2026 election. | To be determined in the 2026 election. | 41 | 120th | 40 | Re-elected in 2022. Retiring at the end of the term. | Jan 2, 2013 – present | Republican | Tim Scott | 27 |
| To be determined in the 2026 election. | To be determined in the 2026 election. | To be determined in the 2026 election. | To be determined in the 2026 election. | To be determined in the 2026 election. | 41 | 121st | 41 | To be determined in the 2028 election. | To be determined in the 2028 election. | To be determined in the 2028 election. | To be determined in the 2028 election. | To be determined in the 2028 election. |
| # | Senator | Party | Years in office | Electoral history | T | C | T | Electoral history | Years in office | Party | Senator | # |
| Class 2 | Class 2 | Class 2 | Class 2 | Class 2 | Class 2 | C | Class 3 | Class 3 | Class 3 | Class 3 | Class 3 | Class 3 |