# Argyreia nervosa

Argyreia nervosa is a perennial climbing vine native to the Indian subcontinent and introduced to numerous areas worldwide, including Hawaii, Africa, and the Caribbean. Though it can be invasive, it is often prized for its aesthetic and medicinal value. Common names include Hawaiian baby woodrose, adhoguda अधोगुडा or vidhara विधारा (Sanskrit), elephant creeper and woolly morning glory. Its seeds are known for their powerful entheogenic properties, greater or similar to those of Ipomoea species, with users reporting significant psychedelic and spiritual experiences. The two botanical varieties are Argyreia nervosa var. nervosa described here, and Argyreia nervosa var. speciosa, the roots of which are used in Ayurvedic medicine.
Argyreia nervosa contains various ergoline alkaloids such as ergine. A study reported stereoisomers of ergine to be found in the seeds at a concentration of 0.325% of dry weight. Two modern studies from a team of researchers also revealed lysergic acid, methylergometrine (syn. lysergic acid butanolamide), methysergide, lysergylalanine, and suspected, unidentifed ergopeptines. A study of the related Ipomoea tricolor showed that ergoline concentrations in the leaves are 12-fold lower than that of the seeds.

## History

While seeds of other Convolvulaceae, specifically Ipomoea corymbosa (ololiuhqui) and Ipomoea tricolor (tlitliltzin), were used in shamanic rituals of Latin America for centuries, A. nervosa was not traditionally used for this purpose. Its properties were first brought to attention in the 1960s.

## Cultivation

Where temperatures fall below 13 °C (55 °F), Argyreia nervosa is grown in a warm greenhouse. Elsewhere, it is grown on arbours, pergolas, walls, or trees. It is often grown professionally under glass in a loam-based potting compost (John Innes No. 3) in full light, and watered freely from spring to autumn, with a balanced liquid fertilizer applied monthly and reduced water in winter. It is grown outdoors in moderately fertile, moist but well-drained soil in full sun. Pruning is done in late winter.

### Glycosides

* Argyroside, (24R)-ergost-5-en-11-oxo-3β-ol-α-D-glucopyranoside, a steroidal glycoside unique to Argyreia nervosa

### Ergolines

Ergoline alkaloids of known percentage :
| Compound name | Percentage of dry seed weight constituted |
| Isoergine | 0.188% |
| Ergine | 0.136% |
| Ergometrine | 0.049% |
| Lysergic acid hydroxyethylamide | 0.035% |
| Isolysergic acid hydroxyethylamide | 0.024% |
| Elymoclavine | 0.022% |
| Ergometrinine | 0.011% |
| Chanoclavine | 0.016% |
Ergoline alkaloids of unknown percentage :
* Compound name
* Agroclavine
* Festuclavine
* Chanoclavine II
* Lysergene
* Lysergol
* Isolysergol
* Setoclavine
* Isosetoclavine

### Hydroxycinnamic acids

Hydroxycinnamic acids :
| Compound name | Chemical structure |
| Caffeic acid | |
| Ethyl caffeate | |

### Fatty acids

Fatty acids :
* Compound name
* Myristoleic acid
* Myristic acid
* Palmitic acid
* Linoleic acid
* Linolenic acid
* Oleic acid
* Stearic acid
* Nonadecylic acid
* Eicosenoic acid
* Heneicosylic acid
* Behenic acid
* 12-methylmyristic acid
* 15-methylstearic acid
Glycosides of fatty acids :
* Fatty acid
* Palmitic acid
* Oleic acid
* Stearic acid
* Behenic acid
* Linoleic acid
* Linolenic acid

## Entheogen

Certain New Age sources claim that, according to 'various oral histories' Huna shamans used the powdered seeds to prepare an entheogenic drink. This is unlikely to reflect an authentic practice having once formed a part of traditional Hawaiian Religion, given that Huna has been widely discredited as a culturally appropriative New Age religion invented by Max Freedom Long. The seeds of Argyreia nervosa can produce psychoactive effects, but it has not yet been demonstrated satisfactorily that their use as an entheogen predates the various countercultural movements of the 1960s. Given that A. nervosa is not native to Hawaii, having been introduced there from India, any Hawaiian practices involving it are unlikely to be of any antiquity. It cannot, however, be ruled out that the plant may have been utilised as an intoxicant in its native India at some time in the past, although evidence for this (if present) has not yet come to light. The seeds of A. nervosa contain ergot alkaloids varying considerably in concentration with LSA weight ranging between exactly similar looking seeds from 3 μg to 34 μg (avg 17 μg). However, in its effects, LSA is about one tenth as potent as its cousin LSD, making a threshold dose level for LSA (D-Lysergic Acid Amide) about 500 μg. The psychoactive effects of the seeds may therefore be due to other alkaloids present in them and the safe and effective dose may be difficult to predict.

## Uses in the traditional medicine of India

While he does not claim there to be any evidence for the use of the seeds of A. nervosa as a traditional entheogen in its native India, Christian Rätsch does describe some interesting traditional uses of the root of the plant in Ayurveda somewhat suggestive of effects upon the CNS:
   The root is regarded as a tonic for the nerves and brain and is ingested as a rejuvenation tonic and aphrodisiac to increase intelligence.
Other traditional uses are in the treatment of gonorrhea, strangury, chronic ulcers, diabetes, anemia, and cerebral disorders. The plant is also used as appetizer, brain tonic, cardiotonic, and aphrodisiac. It possesses anti-inflammatory, immunomodulatory, antibacterial, antiviral, and antifungal activities